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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:USP12-LNX2 (FusionGDB2 ID:97185)

Fusion Gene Summary for USP12-LNX2

Fusion gene summary

Fusion gene information	Fusion gene name: USP12-LNX2
	Fusion gene ID: 97185
		Hgene	Tgene
	Gene symbol	USP12	LNX2
	Gene ID	219333	222484
	Gene name	ubiquitin specific peptidase 12	ligand of numb-protein X 2
	Synonyms	UBH1\|USP12L1	PDZRN1
	Cytomap	13q12.13	13q12.2
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin carboxyl-terminal hydrolase 12deubiquitinating enzyme 12ubiquitin specific protease 12 like 1ubiquitin thioesterase 12ubiquitin thiolesterase 12ubiquitin-hydrolyzing enzyme 1ubiquitin-specific-processing protease 12	ligand of Numb protein X 2PDZ domain containing ring finger 1PDZ domain-containing RING finger protein 1numb-binding protein 2
	Modification date	20200313	20200327
	UniProtAcc	.	Q8N448
	Ensembl transtripts involved in fusion gene	ENST00000282344,	ENST00000316334,
Fusion gene scores	* DoF score	11 X 9 X 6=594	3 X 3 X 2=18
	# samples	12	4
	** MAII score	log2(12/594*10)=-2.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: USP12 [Title/Abstract] AND LNX2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	USP12(27669737)-LNX2(28134122), # samples:1 USP12(27669738)-LNX2(28134122), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	USP12	GO:0016579	protein deubiquitination	19075014\|24145035

Fusion gene breakpoints across USP12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LNX2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-4357-01A	USP12	chr13	27669738	-	LNX2	chr13	28134122	-
ChimerDB4	STAD	TCGA-BR-4357	USP12	chr13	27669737	-	LNX2	chr13	28134122	-

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Fusion Gene ORF analysis for USP12-LNX2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000282344	ENST00000316334	USP12	chr13	27669738	-	LNX2	chr13	28134122	-
In-frame	ENST00000282344	ENST00000316334	USP12	chr13	27669737	-	LNX2	chr13	28134122	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000282344	USP12	chr13	27669737	-	ENST00000316334	LNX2	chr13	28134122	-	4101	830	173	1678	501
ENST00000282344	USP12	chr13	27669738	-	ENST00000316334	LNX2	chr13	28134122	-	4101	830	173	1678	501

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000282344	ENST00000316334	USP12	chr13	27669737	-	LNX2	chr13	28134122	-	0.000225905	0.99977416
ENST00000282344	ENST00000316334	USP12	chr13	27669738	-	LNX2	chr13	28134122	-	0.000225905	0.99977416

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Fusion Genomic Features for USP12-LNX2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP12-LNX2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:27669737/chr13:28134122)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	LNX2 Q8N448
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

LNX2

chr13:27669737

chr13:28134122

ENST00000316334

468_554

408

691.0

Domain

PDZ 3

Tgene

LNX2

chr13:27669737

chr13:28134122

ENST00000316334

600_688

408

691.0

Domain

PDZ 4

Tgene

LNX2

chr13:27669738

chr13:28134122

ENST00000316334

468_554

408

691.0

Domain

PDZ 3

Tgene

LNX2

chr13:27669738

chr13:28134122

ENST00000316334

600_688

408

691.0

Domain

PDZ 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

USP12

chr13:27669737

chr13:28134122

ENST00000282344

39_369

191

371.0

Domain

Note=USP

Hgene

USP12

chr13:27669738

chr13:28134122

ENST00000282344

39_369

191

371.0

Domain

Note=USP

Tgene

LNX2

chr13:27669737

chr13:28134122

ENST00000316334

233_318

408

691.0

Domain

PDZ 1

Tgene

LNX2

chr13:27669737

chr13:28134122

ENST00000316334

339_422

408

691.0

Domain

PDZ 2

Tgene

LNX2

chr13:27669738

chr13:28134122

ENST00000316334

233_318

408

691.0

Domain

PDZ 1

Tgene

LNX2

chr13:27669738

chr13:28134122

ENST00000316334

339_422

408

691.0

Domain

PDZ 2

Tgene

LNX2

chr13:27669737

chr13:28134122

ENST00000316334

208_211

408

691.0

Motif

Note=NPXY motif

Tgene

LNX2

chr13:27669738

chr13:28134122

ENST00000316334

208_211

408

691.0

Motif

Note=NPXY motif

Tgene

LNX2

chr13:27669737

chr13:28134122

ENST00000316334

50_88

408

691.0

Zinc finger

RING-type

Tgene

LNX2

chr13:27669738

chr13:28134122

ENST00000316334

50_88

408

691.0

Zinc finger

RING-type

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Fusion Gene Sequence for USP12-LNX2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>97185_97185_1_USP12-LNX2_USP12_chr13_27669737_ENST00000282344_LNX2_chr13_28134122_ENST00000316334_length(transcript)=4101nt_BP=830nt
CGGAGGCAGCGGCTGCGCCCTGCGCCGGGGCGGAGCCGGGGGCGGGCCGGCGGCCGGCAGGCGGGGGCTGGGGCCCGAGGCCGGGAGTGC
CTGAGCGCCGGCGGCGACGACGGCAGCGGCGGCCCAGCGGGCTCGGTGGTTGGGTCCGCGGCGGCTCGGGGTCCGCCCGCGGGCTGCGGT
GCGAGCGGGCGGCCCGGCTCCCCTCCTCCCCCGCCCGCCGCCGCCGCTGTGATTGGGTGGAAGATGGCGCTGGCCGGATGGAAATCCTAA
TGACAGTCTCCAAATTCGCCTCCATCTGTACCATGGGCGCCAATGCTTCGGCATTAGAGAAAGAGATTGGTCCAGAACAGTTTCCGGTCA
ATGAGCACTATTTTGGATTAGTCAATTTTGGGAATACCTGCTACTGCAATTCAGTTCTTCAAGCACTTTATTTTTGTCGTCCATTTCGGG
AAAAAGTTCTTGCGTATAAGAGTCAACCTAGGAAAAAGGAGAGCCTTCTTACATGCTTAGCAGATCTCTTCCATAGCATAGCCACTCAGA
AGAAAAAGGTTGGAGTAATACCCCCTAAGAAGTTCATCACAAGATTACGGAAAGAAAATGAGCTTTTTGACAACTACATGCAACAAGATG
CCCATGAATTCTTAAATTACCTACTAAATACAATTGCTGATATTTTACAAGAAGAGAGAAAGCAGGAAAAACAAAATGGTCGTTTACCTA
ATGGTAATATTGATAATGAAAATAATAACAGCACACCAGACCCAACGTGGGTTCATGAGATTTTTCAGGGAACATTAACTAATGAAACCA
GATGTCTTACTTGTGAAACTGCCAGTGGAGAGAGAGTGAATTTAACAATTGCTAGACCAGGGAAACCCCAGCCTGGTAACACCATTAGAG
AAGCAGGAAATCATAGCAGCAGCAGCCAGCACCACACACCACCACCGTATTATAGCAGACCAAGCTCACATAAGGATCTTACTCAGTGTG
TTACATGCCAAGAAAAACACATTACTGTAAAGAAGGAACCACATGAATCCCTTGGCATGACCGTTGCTGGGGGCAGGGGAAGTAAGAGTG
GTGAGCTGCCCATCTTTGTGACCAGTGTGCCACCCCATGGCTGCCTTGCACGAGATGGCAGAATAAAGAGAGGTGATGTGTTGCTAAATA
TCAACGGCATTGATTTGACCAATTTAAGTCACAGTGAGGCAGTTGCAATGCTGAAAGCCAGTGCCGCGTCCCCTGCTGTTGCCCTTAAAG
CACTTGAGGTCCAGATTGTTGAGGAGGCGACTCAGAACGCGGAGGAGCAGCCGAGTACTTTCAGCGAAAATGAGTATGATGCCAGTTGGT
CCCCATCATGGGTCATGTGGCTTGGGCTTCCCAGCACACTTCATAGCTGCCACGATATAGTTTTACGAAGAAGTTACTTGGGAAGTTGGG
GCTTTAGTATCGTTGGTGGATATGAAGAGAACCACACCAATCAGCCTTTTTTCATTAAAACTATTGTCTTGGGAACTCCTGCTTATTATG
ATGGAAGATTAAAGTGTGGTGACATGATTGTGGCCGTAAATGGGCTGTCAACCGTGGGCATGAGCCACTCTGCACTAGTTCCCATGTTGA
AGGAGCAGAGGAACAAAGTCACTCTGACCGTTATTTGTTGGCCTGGCAGCCTTGTATAGATTTTGGAAATTGGTTTCAAATCTTGCATCT
TCCTTTTTTAGATTTTTGAAAGAAAACCCTTTGGTTTCATTGTGTTTGTGGTTTAGGAGCTGCTGACACTGCTGGTATACACAGGGCCAA
AACCCACTAAGATTGTCCGTTTATGTTTATTTAAATGGTTTCCTAAGTTAGTTACATTTCTTTTAGCTTGGAAACAGTCTTCCACTAACC
TTTGTGAGTTTATATTTTCAGAATTCAGACTTAGTTGTTAAAATGTTACCTATGGTAATGAGCAAAGCTCACCCAAACTGTGCCCCAGAT
GGAGTAAAGACCTTCTGGTGGGTCTTTGTTTTCAGTAACTGAATCATAGAACGAGTTCTGTATCCCTCAGGCCTGATGTCAGCAAAGCCA
GTAACAACAGCGTGTACTGCCACTGTCATAACCAATACCATGAATGAATATACTTTAAATTTTGGTGATAACTGTTCCCCATTTTTTTTT
GAACCACAGTCTCACTCTCACCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTC
CCACCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGTGTGCCACCATGCCCAGCTAATTTTTTGTACTTTTAGTAGAGACGGGGTTTCAC
CGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTGCCG
CACCCGGCCGTTCCCATTTTTTATTGGTGCCAACATTTCAAAACTTCATACTGTTTATAAACTGATTTTCTGGTTTATTTCTACTGTAAT
CTCTCAATATTCATAGAAGATGAAGAAATAAGTCTGACAACACTAAAGAAATTTCTTAATATACTATTATTAGAATAGTAGAGGATAAAA
GATAATGTTATCCAGTTACAAAGGAATTTGGATGATAATTATAACTTAATGTTAGAGATGGTAAAGCTGCACTTACTTGAACAGCCCAAA
AGCATTAAAAATCTATTTCCAGAGGAATGTTTTGCTATGTAGGGAAATTTTGAAGTAGTTTTTGCTAAAAAATTATTTCTAGAGTTGTGT
TATTCTTAGCAGTAATCTTGGCTAGAAATGTTTTTGTGATTTATGCGATTAAACGAAATGATAAAGATAAAACCATATTATTAAATACCT
ATATATCACAGCTAAGTAGGAGAAAGGGAGACCTTTTTATTTTGTTCAGGTAGGAGTATTTCTTGTGTATTTTAGAAACAATTATTTTTC
CCATTATTTCTTATGAGATTAGTTGTTTCAAGTAGGAGACAGAAAAGTTCTGTTTTGTTGGAAATGTAGGTTTTAGATGTATCTTTCAGT
CAGCTCTCAGTCACTAGACTATTTCATATTTTTTGAAATGTTTTTGAAAATTATGACTAGCCCATTTTTTGTCCTTTATTCAACATACTT
ATCCTCTGAACACATAAATAAGTGAATAAGATAAAAATATCTTTACCTTATTAATATTATACATACTTGAAAAAAATTTCATTTAGAAAC
CTAGTTCAGAATCTGAGCAAATTTACAAGTGACCTCTGTAATAAATGGTATTGATAATCAGAGAATGTATTTCAGAATACTACAGTACAA
TATATTATGAAGCATGACCACTTTATTTTGAAACTTAGCAATTGTATTGCTGGGGTTTATTGTATCTGTAGCATGTCACTGATTATTTCA
GTTAGTTTTATAATGATTTTTAAAAAACATATCTATTTGGAATAAGATACAGCAACAATCATTGCTACTGACTTGTTCAACCCCTTAGTT
ACACTGTATGATCAACATATAACAAGATACAGTGGAATGGCCCATACAGTATATTACTGTTGTGTGATGATTGGCTTTGGAAGCAGTTTG
ATTTTGAAATGCTTTGATATTCTAATTGACATGGAACAAGTTTTTTCCCTGCTCCCCAAATAGAATTTTGTAACCAACTTTGCTATTTTT
TTAAAGTTTGTAAGAATGTGTCATTTCTTGGGGAGTAGCCATCCATCAACAAATATCCTGACTGCTACTTTGTTATATACAAAATACTTA
CATTGAACCTGGTGGCATAATGAGTATTTTGAAAGAAGAAATTTCTTCACTCTCATTTTTATAGAAATCTTGGAATCAGCTTAAGCTGTA
GCTTTTATGACAAAAGACAGTCATTTTTGGTCAGAGTGATATTTGGTGACGGAAACTTGTTCATAATTTATTGTTACTATAGAACTATTT
GGATTTTCTCATTTTTAGTTCTGATAGTTAAATATTTTGGTTTGTTCTGTGCCTTCAGTTTAAATTATTTCAGGATTTTTCAGATGTTTA

>97185_97185_1_USP12-LNX2_USP12_chr13_27669737_ENST00000282344_LNX2_chr13_28134122_ENST00000316334_length(amino acids)=501AA_BP=214
MRCERAARLPSSPARRRRCDWVEDGAGRMEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFCRP
FREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGR
LPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLT
QCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVA
LKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPA

--------------------------------------------------------------
>97185_97185_2_USP12-LNX2_USP12_chr13_27669738_ENST00000282344_LNX2_chr13_28134122_ENST00000316334_length(transcript)=4101nt_BP=830nt
CGGAGGCAGCGGCTGCGCCCTGCGCCGGGGCGGAGCCGGGGGCGGGCCGGCGGCCGGCAGGCGGGGGCTGGGGCCCGAGGCCGGGAGTGC
CTGAGCGCCGGCGGCGACGACGGCAGCGGCGGCCCAGCGGGCTCGGTGGTTGGGTCCGCGGCGGCTCGGGGTCCGCCCGCGGGCTGCGGT
GCGAGCGGGCGGCCCGGCTCCCCTCCTCCCCCGCCCGCCGCCGCCGCTGTGATTGGGTGGAAGATGGCGCTGGCCGGATGGAAATCCTAA
TGACAGTCTCCAAATTCGCCTCCATCTGTACCATGGGCGCCAATGCTTCGGCATTAGAGAAAGAGATTGGTCCAGAACAGTTTCCGGTCA
ATGAGCACTATTTTGGATTAGTCAATTTTGGGAATACCTGCTACTGCAATTCAGTTCTTCAAGCACTTTATTTTTGTCGTCCATTTCGGG
AAAAAGTTCTTGCGTATAAGAGTCAACCTAGGAAAAAGGAGAGCCTTCTTACATGCTTAGCAGATCTCTTCCATAGCATAGCCACTCAGA
AGAAAAAGGTTGGAGTAATACCCCCTAAGAAGTTCATCACAAGATTACGGAAAGAAAATGAGCTTTTTGACAACTACATGCAACAAGATG
CCCATGAATTCTTAAATTACCTACTAAATACAATTGCTGATATTTTACAAGAAGAGAGAAAGCAGGAAAAACAAAATGGTCGTTTACCTA
ATGGTAATATTGATAATGAAAATAATAACAGCACACCAGACCCAACGTGGGTTCATGAGATTTTTCAGGGAACATTAACTAATGAAACCA
GATGTCTTACTTGTGAAACTGCCAGTGGAGAGAGAGTGAATTTAACAATTGCTAGACCAGGGAAACCCCAGCCTGGTAACACCATTAGAG
AAGCAGGAAATCATAGCAGCAGCAGCCAGCACCACACACCACCACCGTATTATAGCAGACCAAGCTCACATAAGGATCTTACTCAGTGTG
TTACATGCCAAGAAAAACACATTACTGTAAAGAAGGAACCACATGAATCCCTTGGCATGACCGTTGCTGGGGGCAGGGGAAGTAAGAGTG
GTGAGCTGCCCATCTTTGTGACCAGTGTGCCACCCCATGGCTGCCTTGCACGAGATGGCAGAATAAAGAGAGGTGATGTGTTGCTAAATA
TCAACGGCATTGATTTGACCAATTTAAGTCACAGTGAGGCAGTTGCAATGCTGAAAGCCAGTGCCGCGTCCCCTGCTGTTGCCCTTAAAG
CACTTGAGGTCCAGATTGTTGAGGAGGCGACTCAGAACGCGGAGGAGCAGCCGAGTACTTTCAGCGAAAATGAGTATGATGCCAGTTGGT
CCCCATCATGGGTCATGTGGCTTGGGCTTCCCAGCACACTTCATAGCTGCCACGATATAGTTTTACGAAGAAGTTACTTGGGAAGTTGGG
GCTTTAGTATCGTTGGTGGATATGAAGAGAACCACACCAATCAGCCTTTTTTCATTAAAACTATTGTCTTGGGAACTCCTGCTTATTATG
ATGGAAGATTAAAGTGTGGTGACATGATTGTGGCCGTAAATGGGCTGTCAACCGTGGGCATGAGCCACTCTGCACTAGTTCCCATGTTGA
AGGAGCAGAGGAACAAAGTCACTCTGACCGTTATTTGTTGGCCTGGCAGCCTTGTATAGATTTTGGAAATTGGTTTCAAATCTTGCATCT
TCCTTTTTTAGATTTTTGAAAGAAAACCCTTTGGTTTCATTGTGTTTGTGGTTTAGGAGCTGCTGACACTGCTGGTATACACAGGGCCAA
AACCCACTAAGATTGTCCGTTTATGTTTATTTAAATGGTTTCCTAAGTTAGTTACATTTCTTTTAGCTTGGAAACAGTCTTCCACTAACC
TTTGTGAGTTTATATTTTCAGAATTCAGACTTAGTTGTTAAAATGTTACCTATGGTAATGAGCAAAGCTCACCCAAACTGTGCCCCAGAT
GGAGTAAAGACCTTCTGGTGGGTCTTTGTTTTCAGTAACTGAATCATAGAACGAGTTCTGTATCCCTCAGGCCTGATGTCAGCAAAGCCA
GTAACAACAGCGTGTACTGCCACTGTCATAACCAATACCATGAATGAATATACTTTAAATTTTGGTGATAACTGTTCCCCATTTTTTTTT
GAACCACAGTCTCACTCTCACCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTC
CCACCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGTGTGCCACCATGCCCAGCTAATTTTTTGTACTTTTAGTAGAGACGGGGTTTCAC
CGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTGCCG
CACCCGGCCGTTCCCATTTTTTATTGGTGCCAACATTTCAAAACTTCATACTGTTTATAAACTGATTTTCTGGTTTATTTCTACTGTAAT
CTCTCAATATTCATAGAAGATGAAGAAATAAGTCTGACAACACTAAAGAAATTTCTTAATATACTATTATTAGAATAGTAGAGGATAAAA
GATAATGTTATCCAGTTACAAAGGAATTTGGATGATAATTATAACTTAATGTTAGAGATGGTAAAGCTGCACTTACTTGAACAGCCCAAA
AGCATTAAAAATCTATTTCCAGAGGAATGTTTTGCTATGTAGGGAAATTTTGAAGTAGTTTTTGCTAAAAAATTATTTCTAGAGTTGTGT
TATTCTTAGCAGTAATCTTGGCTAGAAATGTTTTTGTGATTTATGCGATTAAACGAAATGATAAAGATAAAACCATATTATTAAATACCT
ATATATCACAGCTAAGTAGGAGAAAGGGAGACCTTTTTATTTTGTTCAGGTAGGAGTATTTCTTGTGTATTTTAGAAACAATTATTTTTC
CCATTATTTCTTATGAGATTAGTTGTTTCAAGTAGGAGACAGAAAAGTTCTGTTTTGTTGGAAATGTAGGTTTTAGATGTATCTTTCAGT
CAGCTCTCAGTCACTAGACTATTTCATATTTTTTGAAATGTTTTTGAAAATTATGACTAGCCCATTTTTTGTCCTTTATTCAACATACTT
ATCCTCTGAACACATAAATAAGTGAATAAGATAAAAATATCTTTACCTTATTAATATTATACATACTTGAAAAAAATTTCATTTAGAAAC
CTAGTTCAGAATCTGAGCAAATTTACAAGTGACCTCTGTAATAAATGGTATTGATAATCAGAGAATGTATTTCAGAATACTACAGTACAA
TATATTATGAAGCATGACCACTTTATTTTGAAACTTAGCAATTGTATTGCTGGGGTTTATTGTATCTGTAGCATGTCACTGATTATTTCA
GTTAGTTTTATAATGATTTTTAAAAAACATATCTATTTGGAATAAGATACAGCAACAATCATTGCTACTGACTTGTTCAACCCCTTAGTT
ACACTGTATGATCAACATATAACAAGATACAGTGGAATGGCCCATACAGTATATTACTGTTGTGTGATGATTGGCTTTGGAAGCAGTTTG
ATTTTGAAATGCTTTGATATTCTAATTGACATGGAACAAGTTTTTTCCCTGCTCCCCAAATAGAATTTTGTAACCAACTTTGCTATTTTT
TTAAAGTTTGTAAGAATGTGTCATTTCTTGGGGAGTAGCCATCCATCAACAAATATCCTGACTGCTACTTTGTTATATACAAAATACTTA
CATTGAACCTGGTGGCATAATGAGTATTTTGAAAGAAGAAATTTCTTCACTCTCATTTTTATAGAAATCTTGGAATCAGCTTAAGCTGTA
GCTTTTATGACAAAAGACAGTCATTTTTGGTCAGAGTGATATTTGGTGACGGAAACTTGTTCATAATTTATTGTTACTATAGAACTATTT
GGATTTTCTCATTTTTAGTTCTGATAGTTAAATATTTTGGTTTGTTCTGTGCCTTCAGTTTAAATTATTTCAGGATTTTTCAGATGTTTA

>97185_97185_2_USP12-LNX2_USP12_chr13_27669738_ENST00000282344_LNX2_chr13_28134122_ENST00000316334_length(amino acids)=501AA_BP=214
MRCERAARLPSSPARRRRCDWVEDGAGRMEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFCRP
FREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGR
LPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLT
QCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVA
LKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USP12-LNX2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for USP12-LNX2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for USP12-LNX2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source