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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:USP13-PIK3CA (FusionGDB2 ID:97201)

Fusion Gene Summary for USP13-PIK3CA

Fusion gene summary

Fusion gene information	Fusion gene name: USP13-PIK3CA
	Fusion gene ID: 97201
		Hgene	Tgene
	Gene symbol	USP13	PIK3CA
	Gene ID	8975	5290
	Gene name	ubiquitin specific peptidase 13	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
	Synonyms	ISOT3\|IsoT-3	CLAPO\|CLOVE\|CWS5\|MCAP\|MCM\|MCMTC\|PI3K\|PI3K-alpha\|p110-alpha
	Cytomap	3q26.33	3q26.32
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin carboxyl-terminal hydrolase 13deubiquitinating enzyme 13ubiquitin specific peptidase 13 (isopeptidase T-3)ubiquitin specific protease 13 (isopeptidase T-3)ubiquitin thioesterase 13ubiquitin thiolesterase 13ubiquitin-specific-processing pro	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPI3-kinase p110 subunit alphaphosphatidylinositol 3-kinase, catalytic, 110-KD, alphaphosphatidylinositol 3-kinase, catalytic, alpha polypeptidephosphatidylinositol-4,5-bisph
	Modification date	20200313	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000482333, ENST00000263966, ENST00000496897,	ENST00000263967,
Fusion gene scores	* DoF score	12 X 11 X 6=792	5 X 4 X 5=100
	# samples	12	7
	** MAII score	log2(12/792*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: USP13 [Title/Abstract] AND PIK3CA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	USP13(179418917)-PIK3CA(178941869), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	USP13	GO:0010506	regulation of autophagy	21962518
Hgene	USP13	GO:0035523	protein K29-linked deubiquitination	26280536
Hgene	USP13	GO:0044313	protein K6-linked deubiquitination	26280536
Hgene	USP13	GO:0050821	protein stabilization	21659512\|26280536
Hgene	USP13	GO:0070536	protein K63-linked deubiquitination	22216260\|26280536
Tgene	PIK3CA	GO:0016310	phosphorylation	25327288

Fusion gene breakpoints across USP13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PIK3CA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E2-A14P-01A	USP13	chr3	179418917	-	PIK3CA	chr3	178941869	+
ChimerDB4	BRCA	TCGA-E2-A14P-01A	USP13	chr3	179418917	+	PIK3CA	chr3	178941869	+

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Fusion Gene ORF analysis for USP13-PIK3CA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000482333	ENST00000263967	USP13	chr3	179418917	+	PIK3CA	chr3	178941869	+
In-frame	ENST00000263966	ENST00000263967	USP13	chr3	179418917	+	PIK3CA	chr3	178941869	+
In-frame	ENST00000496897	ENST00000263967	USP13	chr3	179418917	+	PIK3CA	chr3	178941869	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000263966

USP13

chr3

179418917

ENST00000263967

PIK3CA

chr3

178941869

7697

948

357

1967

536

ENST00000496897

USP13

chr3

179418917

ENST00000263967

PIK3CA

chr3

178941869

7116

367

1386

433

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000263966	ENST00000263967	USP13	chr3	179418917	+	PIK3CA	chr3	178941869	+	8.50E-05	0.999915
ENST00000496897	ENST00000263967	USP13	chr3	179418917	+	PIK3CA	chr3	178941869	+	0.000140223	0.9998598

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Fusion Genomic Features for USP13-PIK3CA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
USP13	chr3	179418917	+	PIK3CA	chr3	178941868	+	6.00E-06	0.99999404
USP13	chr3	179418917	+	PIK3CA	chr3	178941868	+	6.00E-06	0.99999404

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP13-PIK3CA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:179418917/chr3:178941869)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PIK3CA

chr3:179418917

chr3:178941869

ENST00000263967

797_1068

729

1069.0

Domain

PI3K/PI4K

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

USP13

chr3:179418917

chr3:178941869

ENST00000263966

336_861

159

864.0

Domain

Note=USP

Hgene

USP13

chr3:179418917

chr3:178941869

ENST00000263966

652_693

159

864.0

Domain

UBA 1

Hgene

USP13

chr3:179418917

chr3:178941869

ENST00000263966

727_767

159

864.0

Domain

UBA 2

Hgene

USP13

chr3:179418917

chr3:178941869

ENST00000496897

336_861

799.0

Domain

Note=USP

Hgene

USP13

chr3:179418917

chr3:178941869

ENST00000496897

652_693

799.0

Domain

UBA 1

Hgene

USP13

chr3:179418917

chr3:178941869

ENST00000496897

727_767

799.0

Domain

UBA 2

Hgene

USP13

chr3:179418917

chr3:178941869

ENST00000263966

209_281

159

864.0

Zinc finger

UBP-type

Hgene

USP13

chr3:179418917

chr3:178941869

ENST00000496897

209_281

799.0

Zinc finger

UBP-type

Tgene

PIK3CA

chr3:179418917

chr3:178941869

ENST00000263967

16_105

729

1069.0

Domain

PI3K-ABD

Tgene

PIK3CA

chr3:179418917

chr3:178941869

ENST00000263967

187_289

729

1069.0

Domain

PI3K-RBD

Tgene

PIK3CA

chr3:179418917

chr3:178941869

ENST00000263967

330_487

729

1069.0

Domain

C2 PI3K-type

Tgene

PIK3CA

chr3:179418917

chr3:178941869

ENST00000263967

517_694

729

1069.0

Domain

PIK helical

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Fusion Gene Sequence for USP13-PIK3CA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>97201_97201_1_USP13-PIK3CA_USP13_chr3_179418917_ENST00000263966_PIK3CA_chr3_178941869_ENST00000263967_length(transcript)=7697nt_BP=948nt
GGCCTCCTCGGAGTTGCCCCTCTGCAAGCCAACAATTCGGGATAGAAAACACCTCCGTGGTGTTTTCCCGGGGCCCTCCCGCGCCGCGTT
CGGCCGCCAGCCCGCTCGAGCTCCCGCGCCAACGCCTCAGGGGTTCGCCCTCCGCCCCCCGCCGCCGCGCCCGGCCCACGCGCAGGGCCC
CTCTCCAGCGCCCCCTCCCCGGCACGCTGCGGCTGGCGCTCCCCAGCCCCGCCTGACGCTGCAGCTGGGCCGGAGACTCGCCATTGGATT
AAAAATAGCGTCGCCAGTCCGCCCCAAGCCCGCGGTGCCCGCTCCCGCCCCGCAGCCCGCTCTCCCCGCCCGCCCCGGCTCGGCCGGCTG
CCGTTGCCCGCGCAGCCCGCCCGTCAGCCCGCTCGCTGGCGCCGCCGCCGCCGGCAGACCCCGCGCTCCGGCTCCGGCTCGGCTCGCTCG
GCTCCGGTGCGCGCCGAGGCCATGCAGCGCCGGGGCGCCCTGTTCGGCATGCCGGGCGGCAGCGGAGGCAGGAAGATGGCTGCAGGAGAC
ATCGGCGAGCTGCTAGTGCCCCACATGCCCACGATCCGCGTGCCCAGGTCCGGCGACAGGGTCTACAAGAACGAGTGCGCCTTCTCCTAC
GACTCTCCCAATTCTGAAGGTGGACTCTATGTATGCATGAATACATTTTTGGCCTTTGGAAGGGAACATGTTGAAAGACATTTTCGAAAA
ACTGGACAGAGTGTATACATGCACCTGAAAAGACATGTGCGAGAGAAGGTAAGAGGGGCGTCTGGTGGAGCGTTACCAAAAAGGAGGAAT
TCCAAGATTTTTTTAGATCTAGATACTGATGACGATTTAAATAGCGACGATTATGAATATGAAGATGAAGCCAAACTTGTTATATTCCCA
GATCACTATGAAATAGCACTACCAAATATTGAGGAGTTACCAGCCCTGGTACAGATGAAGTTTTTAGTTGAGCAAATGAGGCGACCAGAT
TTCATGGATGCTCTACAGGGCTTTCTGTCTCCTCTAAACCCTGCTCATCAACTAGGAAACCTCAGGCTTGAAGAGTGTCGAATTATGTCC
TCTGCAAAAAGGCCACTGTGGTTGAATTGGGAGAACCCAGACATCATGTCAGAGTTACTGTTTCAGAACAATGAGATCATCTTTAAAAAT
GGGGATGATTTACGGCAAGATATGCTAACACTTCAAATTATTCGTATTATGGAAAATATCTGGCAAAATCAAGGTCTTGATCTTCGAATG
TTACCTTATGGTTGTCTGTCAATCGGTGACTGTGTGGGACTTATTGAGGTGGTGCGAAATTCTCACACTATTATGCAAATTCAGTGCAAA
GGCGGCTTGAAAGGTGCACTGCAGTTCAACAGCCACACACTACATCAGTGGCTCAAAGACAAGAACAAAGGAGAAATATATGATGCAGCC
ATTGACCTGTTTACACGTTCATGTGCTGGATACTGTGTAGCTACCTTCATTTTGGGAATTGGAGATCGTCACAATAGTAACATCATGGTG
AAAGACGATGGACAACTGTTTCATATAGATTTTGGACACTTTTTGGATCACAAGAAGAAAAAATTTGGTTATAAACGAGAACGTGTGCCA
TTTGTTTTGACACAGGATTTCTTAATAGTGATTAGTAAAGGAGCCCAAGAATGCACAAAGACAAGAGAATTTGAGAGGTTTCAGGAGATG
TGTTACAAGGCTTATCTAGCTATTCGACAGCATGCCAATCTCTTCATAAATCTTTTCTCAATGATGCTTGGCTCTGGAATGCCAGAACTA
CAATCTTTTGATGACATTGCATACATTCGAAAGACCCTAGCCTTAGATAAAACTGAGCAAGAGGCTTTGGAGTATTTCATGAAACAAATG
AATGATGCACATCATGGTGGCTGGACAACAAAAATGGATTGGATCTTCCACACAATTAAACAGCATGCATTGAACTGAAAAGATAACTGA
GAAAATGAAAGCTCACTCTGGATTCCACACTGCACTGTTAATAACTCTCAGCAGGCAAAGACCGATTGCATAGGAATTGCACAATCCATG
AACAGCATTAGAATTTACAGCAAGAACAGAAATAAAATACTATATAATTTAAATAATGTAAACGCAAACAGGGTTTGATAGCACTTAAAC
TAGTTCATTTCAAAATTAAGCTTTAGAATAATGCGCAATTTCATGTTATGCCTTAAGTCCAAAAAGGTAAACTTTGAAGATTGTTTGTAT
CTTTTTTTAAAAAACAAAACAAAACAAAAATCCCCAAAATATATAGAAATGATGGAGAAGGAAAAAGTGATGGTTTTTTTTGTCTTGCAA
ATGTTCTATGTTTTGAAATGTGGACACAACAAAGGCTGTTATTGCATTAGGTGTAAGTAAACTGGAGTTTATGTTAAATTACATTGATTG
GAAAAGAATGAAAATTTCTTATTTTTCCATTGCTGTTCAATTTATAGTTTGAAGTGGGTTTTTGACTGCTTGTTTAATGAAGAAAAATGC
TTGGGGTGGAAGGGACTCTTGAGATTTCACCAGAGACTTTTTCTTTTTAATAAATCAAACCTTTTGATGATTTGAGGTTTTATCTGCAGT
TTTGGAAGCAGTCACAAATGAGACCTGTTATAAGGTGGTATTTTTTTTTTTCTTCTGGACAGTATTTAAAGGATCTTATTCTTATTTCCC
AGGGAAATTCTGGGCTCCCACAAAGTAAAAAAAAAAAAAAATCATAGAAAAAGAATGAGCAGGAATAGTTCTTATTCCAGAATTGTACAG
TATTCACCTTAAGTTGATTTTTTTTCTCCTTCTGCAATTGAACTGAATACATTTTTCATGCATGTTTTCCAGAAAATAGAAGTATTAATG
TTATTAAAAAGATTATTTTTTTTATTAAAGGCTATTTATATTATAGAAACTATCATTAATATATATTCTTTATTTACATGATCTGTCCCA
TAGTCATGCATTGTTTTGCACCCCAAATTTTTTATTGTTCATAGCAGCATGGTCAGCTTTCTTCTTGATCTATAGATGAGGCTCAGGCAC
TATCCCATTTATACCAATAACCAGTGTATAACTACTTAAGGAAAACATAAAAACTTCATCTTCTTTCCTTTTATTTCTTATGTGAATCTC
CCGTCTTCCATTCTCTTTTATAATTGAGAATGTCTCAATCATATGAAATTAGTTACCAGAATTAACACAATTTAGACTATCTTCCTGATT
CCTTAAACCCCTTTACTGAAGTATACTCATGAATAATACTTTAAAATATGGGGGAATAGAAACCATGAACTTTTTACCTTTTTAAACTAT
TTATCCATATCTCCAAAGTAGAACATTAAACCATTTTAAGATATGTCTCATTCCCAAGTAGTCAGAGCTCACTCTCCAACTTTATTAAAT
ACTATTTGAGCACAGGACACATTCTTAAACATTTTGAAAAACATTAACCCAAGATGTAGAGGCTACTGCTAGTCGTCATTCTAGAATCTG
ATATTTTACTCTGTATTTGAAATGAATGATTAATGTCCTAGGAAATTAGCTTTAGCAGATGTCCAGGTGCCACATCAAAAAAGTGCAATA
ATTATTGACAGTTTTTTAGATTAGGCATATTATTGGAAAACAACTTTATAAAGAGTGAACATTGTATACTCTAGTAAAACAGCATCACTT
TAAAAATATTCATTTATGAAATCTGTTACCTATAGTTGAAGTCTTGAGTAGTGAACAAGGGACTCTAATACCAATACTCTTAATATCTGG
CTATTTTAGATCCCTTAAAGGGCATAATTATTGGAAATTTAGGTATTTCACTAAAGCATGTATATAATATTGCCAACAAGAAAAGTAAAT
TTGAAGATTAAGGGAACTTACTTCTGCAAACTGTCTTGCGATAGTTAAGCAGAATTTAAACTCTGTTTTAAGCAGGAAACCAGAAAGATT
ATTTTGCAGTTGTAGAAGATTTCATAACTTATTAAAACTTATTAACATTTTGTGTTGTTTAGATATAGGCAGTTGATACATACTAACATC
CCAGCCTTTTCAATATCAGGGTTAAATTATAGGAAAACTCAGTAAAATGGTACAAATCTGAAAGTTTGATGGTAGAAACTGAAGATTTAA
CAGAGAACTGTGTTTTACCCGAGTGCCAAAAATGCTGTGAGCCTCCTTGCACAAAATTTATACCACTTTTGCATTTTTATCTATCAGTCC
AGATAGTTGTCTCCCCTCCTTCTCCCAGGACCTCTCCACCATTAAAATGCACAAACCACATGGCCGATTTCACCATTTACATTTATTTTC
AAAAGTTACTACAACCAAATTAATTCTATTAGAAGAAATGTAGACAAATTCTATAAAGACTATAGATTGTGACCTAAGAAAGAAATGAGG
CAAAGAACCAAACATTGAATTAAATGCTACATGGGTGACTAAGATCTGTTTCAAGTCAGTGATAATATAGCCACTTCTGGGTACTTCAGT
ATCAGAGATCAGTTCTCGTGGTTTAGACAGTTCCTATCTATAGCTGACTATCCTTGTCCTTGAATATGGTGTAACTGACTATTGGCTCTA
CAGTTTTATTGGGCCACTTAAGAAATATTTCCTTGAATAATTATTTTGAGAAAAAGTCTAAAAGTAATAAAAATAATTTTAAACACACTG
TAGTAAGAAATGACTGTTGGAAAATTATGCTTTCACTTTCTACCATATTCTCAGCTATACAAAACCATTTATTTTGAAGATTTTTAGACT
ACTGTTAATTTGAAATCTGTTACTCTTATTGTGGAATTTGTTTTTTTAAAAAAGATGTTTCTAATTGGATTTTTAAAAGAAGAATGGAAT
TTGGTTGCTATTTTACAATAGAACCTAAGCTTTTTGTGGTTCTTAGTGTCCTATGTAAAACTTAGTGTCAAAGTAATCAACTTTGAGATT
TTCCCTTCTATTCTGCTTTATATTAAAAGCCCATTAGAAAATGGGAACCTGGTGAATATATAATGAATTGTAAAATATTTTAATGTGTAA
CTTTTTCAACTGTGAAACTGACTTGATTTTTTGATGAAAACAGCTGCTGATAAAGTATTTTGTGTAAAGTGTAGTTCTTATTAATCAGGA
AAATGATGACTTGATTAGACTGTATATGCCCTCTTGGATTTTATTTTAAATGGATTGGTGACTTTCACATAGGTAAAACACAGTCCATCT
GTATTCTTTTTTCCATCAAAAATCGAGTGATTTGGAATTATAAAAAAATTGTGAGCAGCCTATTTGAAAGGCATCATGGAAATTTCACAG
CACAATAACACGGATTTGTTTTTTCTTAATGATGTAAATCCGTTTAATTCATACTTTGATCAATAGCCCATGCTTGCCAACTCTGAAGAA
ATTTAATTTCCAGCAGTATTTTAAAGCTAGCCTGTTAACTTTTTCTGAATATTTAAAGTTCCTCTTTTTTCTATGTCTGCACAAACTGCA
GACCTGGGCTGGACCCACATACTCAAGAGTCCACCTTAAGAAATTATTTTGATGTCCAAGACATCACTAAAATATTTAAGTTTAAAGATA
ATATGTGGTGTTAATAGATTGTGGTGCTTTTACTATTTAAAGACAACTTTCATACTTCAGATGTTTTTGAGAAGAGGGGAATGTGAGGGG
AGGGGGCAGAACAGGGAGGAGTTGTTTGAATGAATTACATTCTTTATATCCATCCTGCTCATTTGGGGCATGTCTTTAAGAGAAGGCTGA
AAGTTGTGAGAGTATATTGTATACCGTAAGAGAATCAACTCTTCATCATGGATGGGATTGTGAAGGCTGAACTATAAAATTCAGCATTGA
CAGCATCCTCAATTAATAATTCTTGGTGACAGAATAATACAGCTGGGCTGTTTTTTAAAATATAAACAATACCATTTTTAATTATTACAT
TAAAAATTGTAAATATATCTATGTGCCATGGCCTGGGAAGCCTGCTTTCTTTTTTCATAAAAATTATTTTTACTGTATGAAAAGATCATG
GGGTTTAGCTCAAAATATCTGTGGTCCTGATAAAATTGGATTGGTAACTCTACCTCAGAAGGAAAATGGGAAAAAAAAATAGATGAGTCA
CAATTCAATACTTCAAGCTCAGAAACTGTGCAGATCACTGAATTTTAGATTTATAAAGTCAGAGTTGGCATGCCTTGTTTTTAATGATAT
GGAAGACCTTAAGAAAAAAACTTGGCTGAAGTTTAATCGTTGGTCCAGCCATTTGAAAAAGGCAATAGTTTGAGGAGGTTCCCGAATTCG
GCATTTGAAATTCATTTTGTTCTCTCTTCTTCATTATTAGTGCATTTGGTGTGTGTATACTTGCACACAATTCTGTTTGTGTACACACTG
CTTGCTTAGCCCTAGTCAAGAGGCATCTTTTATAAAAGGTGTAAAGAAATATCAAGGTTCTAAAATTCGGAAGAGTTTAGAATTTATTAG
GAGTTTCCCAAGTTGGGATGTTAGTCTTTAAATAAACTTCATGCACCTATTCCACTTAAGGTTTTGCACCTCCTTTTTATTAGTGCAGTG
CCATTTCTTCTGCTTGATTTTAGGTATGTTAATATTCCAGCCTTGCTAGTTAGCATAAAGTGACAGGTGTGAGCCATGAGGAAATTTTCT
GACTTAATTTGTACACAACTACATATAAGAGTTTTAGTGGAGGAAAAAAATTAGTCCCTTGTGCGTATACAGTAGTTAGGTAAATGATTT
TTCTACCAACAGTATACTCCATTCCTCATGTAGGTAAGTACAGAAAAGGTTTTTAAATGTATTTTTTTAGCCAGTTAAAGTCTATGAATC
TATCTGCAACCTTATTTAATCTGTCACTATAATAATTTTGTGGTTATGCTAAGAACCATGTATACTTTTAGGTATTCTTATTTTTGTCAA
TTTTTCTAGGTTGGCAAGGAGGCAGAAAACCTTCATTGTTTCATATTAAAATATAATTAGACTAAACTTAATTCTAGTATGAATTTCCAA
AATCATTATCTATTTATTTCATTTTTATTTAATTTTGTTTTTATTTCATTTTTAAAAGTCCCTTGTTCAATTTAACTTATGTTCCTAAGA
GAGGTTGGAGAACTTGGCCTTCATCTGATTTCAAAAATGTTTTGAGTTTCAAATGAAGTTAATGGTTTCAGTGTGATTCAGTCCTCAGAC
CTAATTGGGTTGAATAAAATCTAAAAGAATATACCCTTTTGGAGCATAACATTTTAATACCTTGGGGAATGTGGCACTACCAAAAGAAGA
CTACTAACACGTCAGATGTTCACCTGGAAGCTTTATCAAGAAATTCGAACCACCCTTTTGGCCCCATTAATTGTAGCAAGTTTATTTCTC
TATATTTTGTCATTCAGTGAATTGAAGTCCTGTGGTATACTGCATTCATTAGAAGAAAAACGTTTTTAATGTCCTTTTAATGATGGCCCA
GAAAGCATTTGACACAGCAAGATGCATGTGTTACTATATTGAGAATATAGAATAATAACAGTATCACTAAATTTAAGACCTCTTCCCAGT
CTTGCTGTTCCTAGCAAGAAGTTTGGCCTGTGACTGCACTTACTGTTTATGCTCATCAGAAACTGTCAATGTCTGCTTTTCTTTAACTCT

>97201_97201_1_USP13-PIK3CA_USP13_chr3_179418917_ENST00000263966_PIK3CA_chr3_178941869_ENST00000263967_length(amino acids)=536AA_BP=197
MPLPAQPARQPARWRRRRRQTPRSGSGSARSAPVRAEAMQRRGALFGMPGGSGGRKMAAGDIGELLVPHMPTIRVPRSGDRVYKNECAFS
YDSPNSEGGLYVCMNTFLAFGREHVERHFRKTGQSVYMHLKRHVREKVRGASGGALPKRRNSKIFLDLDTDDDLNSDDYEYEDEAKLVIF
PDHYEIALPNIEELPALVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFK
NGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDA
AIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQE

--------------------------------------------------------------
>97201_97201_2_USP13-PIK3CA_USP13_chr3_179418917_ENST00000496897_PIK3CA_chr3_178941869_ENST00000263967_length(transcript)=7116nt_BP=367nt
GTTCCGAACTGCACGTTGCAGATCGTTTGCGTCCTCCGCGGGGCAGAGCGCAGGGCGGAATTCTGAAGGTGGACTCTATGTATGCATGAA
TACATTTTTGGCCTTTGGAAGGGAACATGTTGAAAGACATTTTCGAAAAACTGGACAGAGTGTATACATGCACCTGAAAAGACATGTGCG
AGAGAAGGTAAGAGGGGCGTCTGGTGGAGCGTTACCAAAAAGGAGGAATTCCAAGATTTTTTTAGATCTAGATACTGATGACGATTTAAA
TAGCGACGATTATGAATATGAAGATGAAGCCAAACTTGTTATATTCCCAGATCACTATGAAATAGCACTACCAAATATTGAGGAGTTACC
AGCCCTGGTACAGATGAAGTTTTTAGTTGAGCAAATGAGGCGACCAGATTTCATGGATGCTCTACAGGGCTTTCTGTCTCCTCTAAACCC
TGCTCATCAACTAGGAAACCTCAGGCTTGAAGAGTGTCGAATTATGTCCTCTGCAAAAAGGCCACTGTGGTTGAATTGGGAGAACCCAGA
CATCATGTCAGAGTTACTGTTTCAGAACAATGAGATCATCTTTAAAAATGGGGATGATTTACGGCAAGATATGCTAACACTTCAAATTAT
TCGTATTATGGAAAATATCTGGCAAAATCAAGGTCTTGATCTTCGAATGTTACCTTATGGTTGTCTGTCAATCGGTGACTGTGTGGGACT
TATTGAGGTGGTGCGAAATTCTCACACTATTATGCAAATTCAGTGCAAAGGCGGCTTGAAAGGTGCACTGCAGTTCAACAGCCACACACT
ACATCAGTGGCTCAAAGACAAGAACAAAGGAGAAATATATGATGCAGCCATTGACCTGTTTACACGTTCATGTGCTGGATACTGTGTAGC
TACCTTCATTTTGGGAATTGGAGATCGTCACAATAGTAACATCATGGTGAAAGACGATGGACAACTGTTTCATATAGATTTTGGACACTT
TTTGGATCACAAGAAGAAAAAATTTGGTTATAAACGAGAACGTGTGCCATTTGTTTTGACACAGGATTTCTTAATAGTGATTAGTAAAGG
AGCCCAAGAATGCACAAAGACAAGAGAATTTGAGAGGTTTCAGGAGATGTGTTACAAGGCTTATCTAGCTATTCGACAGCATGCCAATCT
CTTCATAAATCTTTTCTCAATGATGCTTGGCTCTGGAATGCCAGAACTACAATCTTTTGATGACATTGCATACATTCGAAAGACCCTAGC
CTTAGATAAAACTGAGCAAGAGGCTTTGGAGTATTTCATGAAACAAATGAATGATGCACATCATGGTGGCTGGACAACAAAAATGGATTG
GATCTTCCACACAATTAAACAGCATGCATTGAACTGAAAAGATAACTGAGAAAATGAAAGCTCACTCTGGATTCCACACTGCACTGTTAA
TAACTCTCAGCAGGCAAAGACCGATTGCATAGGAATTGCACAATCCATGAACAGCATTAGAATTTACAGCAAGAACAGAAATAAAATACT
ATATAATTTAAATAATGTAAACGCAAACAGGGTTTGATAGCACTTAAACTAGTTCATTTCAAAATTAAGCTTTAGAATAATGCGCAATTT
CATGTTATGCCTTAAGTCCAAAAAGGTAAACTTTGAAGATTGTTTGTATCTTTTTTTAAAAAACAAAACAAAACAAAAATCCCCAAAATA
TATAGAAATGATGGAGAAGGAAAAAGTGATGGTTTTTTTTGTCTTGCAAATGTTCTATGTTTTGAAATGTGGACACAACAAAGGCTGTTA
TTGCATTAGGTGTAAGTAAACTGGAGTTTATGTTAAATTACATTGATTGGAAAAGAATGAAAATTTCTTATTTTTCCATTGCTGTTCAAT
TTATAGTTTGAAGTGGGTTTTTGACTGCTTGTTTAATGAAGAAAAATGCTTGGGGTGGAAGGGACTCTTGAGATTTCACCAGAGACTTTT
TCTTTTTAATAAATCAAACCTTTTGATGATTTGAGGTTTTATCTGCAGTTTTGGAAGCAGTCACAAATGAGACCTGTTATAAGGTGGTAT
TTTTTTTTTTCTTCTGGACAGTATTTAAAGGATCTTATTCTTATTTCCCAGGGAAATTCTGGGCTCCCACAAAGTAAAAAAAAAAAAAAA
TCATAGAAAAAGAATGAGCAGGAATAGTTCTTATTCCAGAATTGTACAGTATTCACCTTAAGTTGATTTTTTTTCTCCTTCTGCAATTGA
ACTGAATACATTTTTCATGCATGTTTTCCAGAAAATAGAAGTATTAATGTTATTAAAAAGATTATTTTTTTTATTAAAGGCTATTTATAT
TATAGAAACTATCATTAATATATATTCTTTATTTACATGATCTGTCCCATAGTCATGCATTGTTTTGCACCCCAAATTTTTTATTGTTCA
TAGCAGCATGGTCAGCTTTCTTCTTGATCTATAGATGAGGCTCAGGCACTATCCCATTTATACCAATAACCAGTGTATAACTACTTAAGG
AAAACATAAAAACTTCATCTTCTTTCCTTTTATTTCTTATGTGAATCTCCCGTCTTCCATTCTCTTTTATAATTGAGAATGTCTCAATCA
TATGAAATTAGTTACCAGAATTAACACAATTTAGACTATCTTCCTGATTCCTTAAACCCCTTTACTGAAGTATACTCATGAATAATACTT
TAAAATATGGGGGAATAGAAACCATGAACTTTTTACCTTTTTAAACTATTTATCCATATCTCCAAAGTAGAACATTAAACCATTTTAAGA
TATGTCTCATTCCCAAGTAGTCAGAGCTCACTCTCCAACTTTATTAAATACTATTTGAGCACAGGACACATTCTTAAACATTTTGAAAAA
CATTAACCCAAGATGTAGAGGCTACTGCTAGTCGTCATTCTAGAATCTGATATTTTACTCTGTATTTGAAATGAATGATTAATGTCCTAG
GAAATTAGCTTTAGCAGATGTCCAGGTGCCACATCAAAAAAGTGCAATAATTATTGACAGTTTTTTAGATTAGGCATATTATTGGAAAAC
AACTTTATAAAGAGTGAACATTGTATACTCTAGTAAAACAGCATCACTTTAAAAATATTCATTTATGAAATCTGTTACCTATAGTTGAAG
TCTTGAGTAGTGAACAAGGGACTCTAATACCAATACTCTTAATATCTGGCTATTTTAGATCCCTTAAAGGGCATAATTATTGGAAATTTA
GGTATTTCACTAAAGCATGTATATAATATTGCCAACAAGAAAAGTAAATTTGAAGATTAAGGGAACTTACTTCTGCAAACTGTCTTGCGA
TAGTTAAGCAGAATTTAAACTCTGTTTTAAGCAGGAAACCAGAAAGATTATTTTGCAGTTGTAGAAGATTTCATAACTTATTAAAACTTA
TTAACATTTTGTGTTGTTTAGATATAGGCAGTTGATACATACTAACATCCCAGCCTTTTCAATATCAGGGTTAAATTATAGGAAAACTCA
GTAAAATGGTACAAATCTGAAAGTTTGATGGTAGAAACTGAAGATTTAACAGAGAACTGTGTTTTACCCGAGTGCCAAAAATGCTGTGAG
CCTCCTTGCACAAAATTTATACCACTTTTGCATTTTTATCTATCAGTCCAGATAGTTGTCTCCCCTCCTTCTCCCAGGACCTCTCCACCA
TTAAAATGCACAAACCACATGGCCGATTTCACCATTTACATTTATTTTCAAAAGTTACTACAACCAAATTAATTCTATTAGAAGAAATGT
AGACAAATTCTATAAAGACTATAGATTGTGACCTAAGAAAGAAATGAGGCAAAGAACCAAACATTGAATTAAATGCTACATGGGTGACTA
AGATCTGTTTCAAGTCAGTGATAATATAGCCACTTCTGGGTACTTCAGTATCAGAGATCAGTTCTCGTGGTTTAGACAGTTCCTATCTAT
AGCTGACTATCCTTGTCCTTGAATATGGTGTAACTGACTATTGGCTCTACAGTTTTATTGGGCCACTTAAGAAATATTTCCTTGAATAAT
TATTTTGAGAAAAAGTCTAAAAGTAATAAAAATAATTTTAAACACACTGTAGTAAGAAATGACTGTTGGAAAATTATGCTTTCACTTTCT
ACCATATTCTCAGCTATACAAAACCATTTATTTTGAAGATTTTTAGACTACTGTTAATTTGAAATCTGTTACTCTTATTGTGGAATTTGT
TTTTTTAAAAAAGATGTTTCTAATTGGATTTTTAAAAGAAGAATGGAATTTGGTTGCTATTTTACAATAGAACCTAAGCTTTTTGTGGTT
CTTAGTGTCCTATGTAAAACTTAGTGTCAAAGTAATCAACTTTGAGATTTTCCCTTCTATTCTGCTTTATATTAAAAGCCCATTAGAAAA
TGGGAACCTGGTGAATATATAATGAATTGTAAAATATTTTAATGTGTAACTTTTTCAACTGTGAAACTGACTTGATTTTTTGATGAAAAC
AGCTGCTGATAAAGTATTTTGTGTAAAGTGTAGTTCTTATTAATCAGGAAAATGATGACTTGATTAGACTGTATATGCCCTCTTGGATTT
TATTTTAAATGGATTGGTGACTTTCACATAGGTAAAACACAGTCCATCTGTATTCTTTTTTCCATCAAAAATCGAGTGATTTGGAATTAT
AAAAAAATTGTGAGCAGCCTATTTGAAAGGCATCATGGAAATTTCACAGCACAATAACACGGATTTGTTTTTTCTTAATGATGTAAATCC
GTTTAATTCATACTTTGATCAATAGCCCATGCTTGCCAACTCTGAAGAAATTTAATTTCCAGCAGTATTTTAAAGCTAGCCTGTTAACTT
TTTCTGAATATTTAAAGTTCCTCTTTTTTCTATGTCTGCACAAACTGCAGACCTGGGCTGGACCCACATACTCAAGAGTCCACCTTAAGA
AATTATTTTGATGTCCAAGACATCACTAAAATATTTAAGTTTAAAGATAATATGTGGTGTTAATAGATTGTGGTGCTTTTACTATTTAAA
GACAACTTTCATACTTCAGATGTTTTTGAGAAGAGGGGAATGTGAGGGGAGGGGGCAGAACAGGGAGGAGTTGTTTGAATGAATTACATT
CTTTATATCCATCCTGCTCATTTGGGGCATGTCTTTAAGAGAAGGCTGAAAGTTGTGAGAGTATATTGTATACCGTAAGAGAATCAACTC
TTCATCATGGATGGGATTGTGAAGGCTGAACTATAAAATTCAGCATTGACAGCATCCTCAATTAATAATTCTTGGTGACAGAATAATACA
GCTGGGCTGTTTTTTAAAATATAAACAATACCATTTTTAATTATTACATTAAAAATTGTAAATATATCTATGTGCCATGGCCTGGGAAGC
CTGCTTTCTTTTTTCATAAAAATTATTTTTACTGTATGAAAAGATCATGGGGTTTAGCTCAAAATATCTGTGGTCCTGATAAAATTGGAT
TGGTAACTCTACCTCAGAAGGAAAATGGGAAAAAAAAATAGATGAGTCACAATTCAATACTTCAAGCTCAGAAACTGTGCAGATCACTGA
ATTTTAGATTTATAAAGTCAGAGTTGGCATGCCTTGTTTTTAATGATATGGAAGACCTTAAGAAAAAAACTTGGCTGAAGTTTAATCGTT
GGTCCAGCCATTTGAAAAAGGCAATAGTTTGAGGAGGTTCCCGAATTCGGCATTTGAAATTCATTTTGTTCTCTCTTCTTCATTATTAGT
GCATTTGGTGTGTGTATACTTGCACACAATTCTGTTTGTGTACACACTGCTTGCTTAGCCCTAGTCAAGAGGCATCTTTTATAAAAGGTG
TAAAGAAATATCAAGGTTCTAAAATTCGGAAGAGTTTAGAATTTATTAGGAGTTTCCCAAGTTGGGATGTTAGTCTTTAAATAAACTTCA
TGCACCTATTCCACTTAAGGTTTTGCACCTCCTTTTTATTAGTGCAGTGCCATTTCTTCTGCTTGATTTTAGGTATGTTAATATTCCAGC
CTTGCTAGTTAGCATAAAGTGACAGGTGTGAGCCATGAGGAAATTTTCTGACTTAATTTGTACACAACTACATATAAGAGTTTTAGTGGA
GGAAAAAAATTAGTCCCTTGTGCGTATACAGTAGTTAGGTAAATGATTTTTCTACCAACAGTATACTCCATTCCTCATGTAGGTAAGTAC
AGAAAAGGTTTTTAAATGTATTTTTTTAGCCAGTTAAAGTCTATGAATCTATCTGCAACCTTATTTAATCTGTCACTATAATAATTTTGT
GGTTATGCTAAGAACCATGTATACTTTTAGGTATTCTTATTTTTGTCAATTTTTCTAGGTTGGCAAGGAGGCAGAAAACCTTCATTGTTT
CATATTAAAATATAATTAGACTAAACTTAATTCTAGTATGAATTTCCAAAATCATTATCTATTTATTTCATTTTTATTTAATTTTGTTTT
TATTTCATTTTTAAAAGTCCCTTGTTCAATTTAACTTATGTTCCTAAGAGAGGTTGGAGAACTTGGCCTTCATCTGATTTCAAAAATGTT
TTGAGTTTCAAATGAAGTTAATGGTTTCAGTGTGATTCAGTCCTCAGACCTAATTGGGTTGAATAAAATCTAAAAGAATATACCCTTTTG
GAGCATAACATTTTAATACCTTGGGGAATGTGGCACTACCAAAAGAAGACTACTAACACGTCAGATGTTCACCTGGAAGCTTTATCAAGA
AATTCGAACCACCCTTTTGGCCCCATTAATTGTAGCAAGTTTATTTCTCTATATTTTGTCATTCAGTGAATTGAAGTCCTGTGGTATACT
GCATTCATTAGAAGAAAAACGTTTTTAATGTCCTTTTAATGATGGCCCAGAAAGCATTTGACACAGCAAGATGCATGTGTTACTATATTG
AGAATATAGAATAATAACAGTATCACTAAATTTAAGACCTCTTCCCAGTCTTGCTGTTCCTAGCAAGAAGTTTGGCCTGTGACTGCACTT
ACTGTTTATGCTCATCAGAAACTGTCAATGTCTGCTTTTCTTTAACTCTGCAGTCTGTAACATCACGCTGTTTATTAAAAAAAAAAAGAA

>97201_97201_2_USP13-PIK3CA_USP13_chr3_179418917_ENST00000496897_PIK3CA_chr3_178941869_ENST00000263967_length(amino acids)=433AA_BP=94
MNTFLAFGREHVERHFRKTGQSVYMHLKRHVREKVRGASGGALPKRRNSKIFLDLDTDDDLNSDDYEYEDEAKLVIFPDHYEIALPNIEE
LPALVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQ
IIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYC
VATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for USP13-PIK3CA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for USP13-PIK3CA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for USP13-PIK3CA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source