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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:USP14-LARP1B (FusionGDB2 ID:97209)

Fusion Gene Summary for USP14-LARP1B

Fusion gene summary

Fusion gene information	Fusion gene name: USP14-LARP1B
	Fusion gene ID: 97209
		Hgene	Tgene
	Gene symbol	USP14	LARP1B
	Gene ID	9097	55132
	Gene name	ubiquitin specific peptidase 14	La ribonucleoprotein 1B
	Synonyms	TGT	LARP2
	Cytomap	18p11.32	4q28.2
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin carboxyl-terminal hydrolase 14deubiquitinating enzyme 14tRNA-guanine transglycosylase, 60-kD subunitubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)ubiquitin specific protease 14 (tRNA-guanine transglycosylase)ubiquitin thioe	la-related protein 1BLa ribonucleoprotein domain family member 1BLa ribonucleoprotein domain family, member 2la-related protein 2
	Modification date	20200329	20200313
	UniProtAcc	.	Q659C4
	Ensembl transtripts involved in fusion gene	ENST00000261601, ENST00000582707, ENST00000383589, ENST00000400266,	ENST00000354456, ENST00000394288, ENST00000427266, ENST00000432347, ENST00000506199, ENST00000512292, ENST00000264584, ENST00000326639, ENST00000441387,
Fusion gene scores	* DoF score	9 X 7 X 5=315	12 X 15 X 3=540
	# samples	9	14
	** MAII score	log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/540*10)=-1.94753258010586 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: USP14 [Title/Abstract] AND LARP1B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	USP14(166819)-LARP1B(129028293), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	USP14	GO:0016579	protein deubiquitination	23958854

Fusion gene breakpoints across USP14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LARP1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-2024	USP14	chr18	166819	+	LARP1B	chr4	129028293	+

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Fusion Gene ORF analysis for USP14-LARP1B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000261601	ENST00000354456	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
5CDS-5UTR	ENST00000582707	ENST00000354456	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
5CDS-intron	ENST00000261601	ENST00000394288	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
5CDS-intron	ENST00000261601	ENST00000427266	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
5CDS-intron	ENST00000261601	ENST00000432347	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
5CDS-intron	ENST00000261601	ENST00000506199	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
5CDS-intron	ENST00000261601	ENST00000512292	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
5CDS-intron	ENST00000582707	ENST00000394288	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
5CDS-intron	ENST00000582707	ENST00000427266	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
5CDS-intron	ENST00000582707	ENST00000432347	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
5CDS-intron	ENST00000582707	ENST00000506199	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
5CDS-intron	ENST00000582707	ENST00000512292	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
In-frame	ENST00000261601	ENST00000264584	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
In-frame	ENST00000261601	ENST00000326639	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
In-frame	ENST00000261601	ENST00000441387	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
In-frame	ENST00000582707	ENST00000264584	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
In-frame	ENST00000582707	ENST00000326639	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
In-frame	ENST00000582707	ENST00000441387	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-3CDS	ENST00000383589	ENST00000264584	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-3CDS	ENST00000383589	ENST00000326639	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-3CDS	ENST00000383589	ENST00000441387	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-3CDS	ENST00000400266	ENST00000264584	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-3CDS	ENST00000400266	ENST00000326639	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-3CDS	ENST00000400266	ENST00000441387	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-5UTR	ENST00000383589	ENST00000354456	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-5UTR	ENST00000400266	ENST00000354456	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-intron	ENST00000383589	ENST00000394288	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-intron	ENST00000383589	ENST00000427266	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-intron	ENST00000383589	ENST00000432347	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-intron	ENST00000383589	ENST00000506199	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-intron	ENST00000383589	ENST00000512292	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-intron	ENST00000400266	ENST00000394288	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-intron	ENST00000400266	ENST00000427266	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-intron	ENST00000400266	ENST00000432347	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-intron	ENST00000400266	ENST00000506199	USP14	chr18	166819	+	LARP1B	chr4	129028293	+
intron-intron	ENST00000400266	ENST00000512292	USP14	chr18	166819	+	LARP1B	chr4	129028293	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000582707	USP14	chr18	166819	+	ENST00000326639	LARP1B	chr4	129028293	+	4378	511	109	2442	777
ENST00000582707	USP14	chr18	166819	+	ENST00000264584	LARP1B	chr4	129028293	+	3486	511	109	2406	765
ENST00000582707	USP14	chr18	166819	+	ENST00000441387	LARP1B	chr4	129028293	+	3412	511	109	2061	650
ENST00000261601	USP14	chr18	166819	+	ENST00000326639	LARP1B	chr4	129028293	+	4153	286	13	2217	734
ENST00000261601	USP14	chr18	166819	+	ENST00000264584	LARP1B	chr4	129028293	+	3261	286	13	2181	722
ENST00000261601	USP14	chr18	166819	+	ENST00000441387	LARP1B	chr4	129028293	+	3187	286	13	1836	607

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000582707	ENST00000326639	USP14	chr18	166819	+	LARP1B	chr4	129028293	+	0.000218031	0.999782
ENST00000582707	ENST00000264584	USP14	chr18	166819	+	LARP1B	chr4	129028293	+	0.000395054	0.999605
ENST00000582707	ENST00000441387	USP14	chr18	166819	+	LARP1B	chr4	129028293	+	0.000319034	0.999681
ENST00000261601	ENST00000326639	USP14	chr18	166819	+	LARP1B	chr4	129028293	+	0.0002101	0.9997899
ENST00000261601	ENST00000264584	USP14	chr18	166819	+	LARP1B	chr4	129028293	+	0.000341529	0.99965847
ENST00000261601	ENST00000441387	USP14	chr18	166819	+	LARP1B	chr4	129028293	+	0.000286239	0.9997137

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Fusion Genomic Features for USP14-LARP1B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
USP14	chr18	166819	+	LARP1B	chr4	129028293	+	0.001804544	0.99819547
USP14	chr18	166819	+	LARP1B	chr4	129028293	+	0.001804544	0.99819547

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP14-LARP1B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:166819/chr4:129028293)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	LARP1B Q659C4
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

LARP1B

chr18:166819

chr4:129028293

ENST00000354456

114_167

282.0

Compositional bias

Note=Arg-rich

Tgene

LARP1B

chr18:166819

chr4:129028293

ENST00000354456

209_299

282.0

Domain

HTH La-type RNA-binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

USP14

chr18:166819

chr4:129028293

ENST00000261601

105_483

495.0

Domain

Note=USP

Hgene

USP14

chr18:166819

chr4:129028293

ENST00000261601

4_80

495.0

Domain

Ubiquitin-like

Hgene

USP14

chr18:166819

chr4:129028293

ENST00000582707

105_483

460.0

Domain

Note=USP

Hgene

USP14

chr18:166819

chr4:129028293

ENST00000582707

4_80

460.0

Domain

Ubiquitin-like

Tgene

LARP1B

chr18:166819

chr4:129028293

ENST00000264584

114_167

224

856.0

Compositional bias

Note=Arg-rich

Tgene

LARP1B

chr18:166819

chr4:129028293

ENST00000326639

114_167

271

915.0

Compositional bias

Note=Arg-rich

Tgene

LARP1B

chr18:166819

chr4:129028293

ENST00000394288

114_167

271

336.0

Compositional bias

Note=Arg-rich

Tgene

LARP1B

chr18:166819

chr4:129028293

ENST00000441387

114_167

271

1195.6666666666667

Compositional bias

Note=Arg-rich

Tgene

LARP1B

chr18:166819

chr4:129028293

ENST00000264584

209_299

224

856.0

Domain

HTH La-type RNA-binding

Tgene

LARP1B

chr18:166819

chr4:129028293

ENST00000326639

209_299

271

915.0

Domain

HTH La-type RNA-binding

Tgene

LARP1B

chr18:166819

chr4:129028293

ENST00000394288

209_299

271

336.0

Domain

HTH La-type RNA-binding

Tgene

LARP1B

chr18:166819

chr4:129028293

ENST00000441387

209_299

271

1195.6666666666667

Domain

HTH La-type RNA-binding

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Fusion Gene Sequence for USP14-LARP1B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>97209_97209_1_USP14-LARP1B_USP14_chr18_166819_ENST00000261601_LARP1B_chr4_129028293_ENST00000264584_length(transcript)=3261nt_BP=286nt
GCCGCCGCCGCAGCTGCTCCTGGTCCCCGTCCCTTTGCCGCCCTCGTCAGGCCCAGCTCTCCTGCGCCGCCGCCTCCCGCCGCGCCCCGC
CATGCCGCTCTACTCCGTTACTGTAAAATGGGGAAAGGAGAAATTTGAAGGTGTAGAATTGAATACAGATGAACCTCCAATGGTATTCAA
GGCTCAGCTGTTTGCGTTGACTGGAGTCCAGCCTGCCAGACAGAAAGTTATGGTGAAAGGAGGAACGCTAAAGGATGATGATTGGGGAAA
CATCAAAATAAAAAATGCACTGAAGGATAGCACAGAAGTAGAAATTGTGGATGAGAAAATGAGAAAAAAGATAGAACCAGAAAAATGGCC
AATTCCAGGCCCTCCTCCACGCAGTGTGCCACCAACAGACTTCTCTCAACTGATTGATTGTCCAGAGTTTGTACCAGGCCAAGCCTTTTG
CTCACATACAGAGTCTGCCCCAAATTCTCCAAGAATTGGAAGCCCATTGAGCCCAAAGAAAAACAGTGAAACAAGTATTCTTCAAGCAAT
GTCTAGAGGTTTGTCTACCAGTTTGCCTGACTTGGACTCAGAACCTTGGATAGAAGTTAAAAAAAGACATCAGCCAGCCCCAGTGAAATT
GAGGGAATCAGTGTCTGTCCCTGAAGGGTCATTAAATCAGCTATGTTCTTCAGAAGAACCAGAACAAGAAGAACTTGATTTTTTGTTTGA
TGAAGAGATTGAACAAATAGGACGAAAAAACACATTTACTGATTGGTCTGATAATGATTCAGATTATGAAATTGATGACCAAGACTTAAA
CAAGATTTTGATTGTAACTCAGACACCACCTTATGTGAAAAAACATCCTGGAGGAGATCGAACAGGCACCCACATGTCTCGGGCAAAAAT
CACATCTGAACTTGCTAAAGTTATCAATGATGGCTTATACTATTATGAACAGGATCTATGGATGGAAGAAGATGAAAACAAACACACAGC
CATAAAGCAAGAAGTTGAGAACTTTAAGAAGCTAAATCTCATTAGTAAAGAGCAGTTTGAAAACCTAACACCTGAACTTCCTTTTGAGCC
AAACCAAGAAGTTCCTGTAGCACCTTCACAGTCCAGGCAAGATTTGACTGATGAATTAGCTCAGAAGTTATTTGATGTTTCAGAAATAAC
TTCAGCAGCAATGGTTCATTCGTTGCCTACAGCAGTTCCAGAATCTCCTAGAATTCATCCTACAAGAACACCCAAAACACCTCGAACACC
TAGGTTACAAGATCCTAACAAAACACCAAGATTTTATCCTGTTGTTAAAGAACCAAAAGCCATTGATGTAAAGAGTCCAAGAAAGAGAAA
AACAAGGCATAGCACAAATCCCCCTCTAGAGTGTCATGTTGGTTGGGTAATGGATTCCAGAGACCGTGGGCCAGGAACATCCTCTGTCAG
CACTTCAAATGCTTCACCTTCAGAAGGCGCACCACTAGCAGGAAGTTATGGATGTACTCCTCATTCATTCCCAAAGTTCCAGCATCCTTC
TCATGAACTTTTGAAGGAAAATGGCTTTACCCAACAAGTGTACCACAAGTATCGTCGAAGATGCCTAAGTGAGAGAAAACGCTTGGGAAT
TGGTCAGTCCCAAGAAATGAATACCCTCTTTCGTTTCTGGTCCTTTTTCCTCAGAGATCACTTCAATAAAAAAATGTATGAGGAATTTAG
ACAACTTGCTTGGGAAGATGCAAAAGAAAATTACAGGTATGGGTTAGAATGTCTGTTCAGGTTTTATAGTTATGGACTGGAAAAAAAATT
CAGGCGAGAAATTTTTCAGGATTTCCAAGAAGAAACCAAAAAAGACTACGAATCTGGTCAGCTGTATGGACTAGAAAAGTTTTGGGCTTA
TTTGAAATATTCTCAATCTAAGACACAGTCTATTGACCCAAAACTTCAGGAATACCTCTGTAGTTTTAAGAGGTTAGAAGACTTCCGTGT
TGATCCCCCTATTAGTGATGAATTTGGAAGAAAAAGACATTCCTCTACTTCTGGTGAGGAGAGTAATCGTCATAGACTTCCACCTAATTC
CTCTACAAAGCCACCAAATGCTGCTAAACCTACATCTACCAGTGAGCTTCAGGTACCAATAAACTCTCCCAGAAGGAATATTTCACCGGA
GTCCAGTGACAATTCACATTAAACAGTGCTGCCTGTGTCCTGTGGTCTCAAGAAATGGTGAAATGCCTGAGAAATAGACTCTTATGAAAG
TTCTTTGTCCTTGAAGTCAACATTTACATCAGTATTTATTTGGGGAAAATCTTCTGGTGTTTAATTGTGATAATAAGAAAGAAGAAAAAG
AAAGAAAAGTGGTAGCATTTTTTCTAACAAGATAAATTCTAAAAATGTTTTCCCTGATTTCACAAACAAGGATAGTCTTGGTGACCTTTT
ATAGAGATCTTCTAGTAATGTATTTTGATCTCAGATTTCTTTTTCAAAGCCATGGTTTTACAAAAACAGCATTCCTTAAATATATTTAAA
AAACAATACAAGGAATGCCTAACATTTCAGCTCATACTTCTTAAAGAAGATATAGTATGTTGTATTCTCTTCTTAGAGCTTTCTTAAAGA
ATCCACAATCCAATTACCCCACTGTCAATTCATATTTGAACTTACCAAAACAAAGGAGGATTACGTATATGTTTTTTAAATTCAAAAAAG
AATATGAAATTATACCTTTAGTATCCCTTTGAGACATATAGTTTAAAGAAAACTTTTTTTAAAACAAAAGTAGGAATATATAGTAAGATT
GTAGTTACAATGAGTATATGCACTTTTGATGCTAGGTTTTGCTTTTCTCCCCCCAGTCATATCTCATGATTTCCACAGTTGTTGTATTGG
TGTGGAGTTTTCTGAATTGGCTATAAGCTGATTACATATTAGAGGTTTATTTTTATGATTCTATATAAACGTGCACGAGTAATTTAAAAC
CTGCATTGGGATTGATTGGAATATTGTCCTAAATTAATTAAATCTTGCACTGTTTTGAATGCATCTGCTATTTATACATCTGCAAGTGGG
TATGTCATAAGGAGTCAGATTATCTTTAATTTAAAATGAATACTTAGTTTTACCTTTTTGTTTATTTTTTGTTTAATTTTGTTTTTATAA
ATGTTTTCAAGAGTTATAGCAAATTGATTTCTAATTTTTATTGCTATTACAACTGATGTAAATGGTAGTTTCAGTTTTTGTGAGATTTAA

>97209_97209_1_USP14-LARP1B_USP14_chr18_166819_ENST00000261601_LARP1B_chr4_129028293_ENST00000264584_length(amino acids)=722AA_BP=85
MLLVPVPLPPSSGPALLRRRLPPRPAMPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIK
NALKDSTEVEIVDEKMRKKIEPEKWPIPGPPPRSVPPTDFSQLIDCPEFVPGQAFCSHTESAPNSPRIGSPLSPKKNSETSILQAMSRGL
STSLPDLDSEPWIEVKKRHQPAPVKLRESVSVPEGSLNQLCSSEEPEQEELDFLFDEEIEQIGRKNTFTDWSDNDSDYEIDDQDLNKILI
VTQTPPYVKKHPGGDRTGTHMSRAKITSELAKVINDGLYYYEQDLWMEEDENKHTAIKQEVENFKKLNLISKEQFENLTPELPFEPNQEV
PVAPSQSRQDLTDELAQKLFDVSEITSAAMVHSLPTAVPESPRIHPTRTPKTPRTPRLQDPNKTPRFYPVVKEPKAIDVKSPRKRKTRHS
TNPPLECHVGWVMDSRDRGPGTSSVSTSNASPSEGAPLAGSYGCTPHSFPKFQHPSHELLKENGFTQQVYHKYRRRCLSERKRLGIGQSQ
EMNTLFRFWSFFLRDHFNKKMYEEFRQLAWEDAKENYRYGLECLFRFYSYGLEKKFRREIFQDFQEETKKDYESGQLYGLEKFWAYLKYS
QSKTQSIDPKLQEYLCSFKRLEDFRVDPPISDEFGRKRHSSTSGEESNRHRLPPNSSTKPPNAAKPTSTSELQVPINSPRRNISPESSDN

--------------------------------------------------------------
>97209_97209_2_USP14-LARP1B_USP14_chr18_166819_ENST00000261601_LARP1B_chr4_129028293_ENST00000326639_length(transcript)=4153nt_BP=286nt
GCCGCCGCCGCAGCTGCTCCTGGTCCCCGTCCCTTTGCCGCCCTCGTCAGGCCCAGCTCTCCTGCGCCGCCGCCTCCCGCCGCGCCCCGC
CATGCCGCTCTACTCCGTTACTGTAAAATGGGGAAAGGAGAAATTTGAAGGTGTAGAATTGAATACAGATGAACCTCCAATGGTATTCAA
GGCTCAGCTGTTTGCGTTGACTGGAGTCCAGCCTGCCAGACAGAAAGTTATGGTGAAAGGAGGAACGCTAAAGGATGATGATTGGGGAAA
CATCAAAATAAAAAATGCACTGAAGGATAGCACAGAAGTAGAAATTGTGGATGAGAAAATGAGAAAAAAGATAGAACCAGAAAAATGGCC
AATTCCAGGCCCTCCTCCACGCAGTGTGCCACCAACAGACTTCTCTCAACTGATTGATTGTCCAGAGTTTGTACCAGGCCAAGCCTTTTG
CTCACATACAGAGTCTGCCCCAAATTCTCCAAGAATTGGAAGCCCATTGAGCCCAAAGAAAAACAGTGAAACAAGTATTCTTCAAGCAAT
GTCTAGAGGTTTGTCTACCAGTTTGCCTGACTTGGACTCAGAACCTTGGATAGAAGTTAAAAAAAGACATCAGCCAGCCCCAGTGAAATT
GAGGGAATCAGTGTCTGTCCCTGAAGGGTCATTAAATCAGCTATGTTCTTCAGAAGAACCAGAACAAGAAGAACTTGATTTTTTGTTTGA
TGAAGAGATTGAACAAATAGGACGAAAAAACACATTTACTGATTGGTCTGATAATGATTCAGATTATGAAATTGATGACCAAGACTTAAA
CAAGATTTTGATTGTAACTCAGACACCACCTTATGTGAAAAAACATCCTGGAGGAGATCGAACAGGCACCCACATGTCTCGGGCAAAAAT
CACATCTGAACTTGCTAAAGTTATCAATGATGGCTTATACTATTATGAACAGGATCTATGGATGGAAGAAGATGAAAACAAACACACAGC
CATAAAGCAAGAAGTTGAGAACTTTAAGAAGCTAAATCTCATTAGTAAAGAGCAGTTTGAAAACCTAACACCTGAACTTCCTTTTGAGCC
AAACCAAGAAGTTCCTGTAGCACCTTCACAGTCCAGGCAAGGAGGTGTTCAAGGAGTGCTTCACATTCCCAAGAAAGATTTGACTGATGA
ATTAGCTCAGAAGTTATTTGATGTTTCAGAAATAACTTCAGCAGCAATGGTTCATTCGTTGCCTACAGCAGTTCCAGAATCTCCTAGAAT
TCATCCTACAAGAACACCCAAAACACCTCGAACACCTAGGTTACAAGATCCTAACAAAACACCAAGATTTTATCCTGTTGTTAAAGAACC
AAAAGCCATTGATGTAAAGAGTCCAAGAAAGAGAAAAACAAGGCATAGCACAAATCCCCCTCTAGAGTGTCATGTTGGTTGGGTAATGGA
TTCCAGAGACCGTGGGCCAGGAACATCCTCTGTCAGCACTTCAAATGCTTCACCTTCAGAAGGCGCACCACTAGCAGGAAGTTATGGATG
TACTCCTCATTCATTCCCAAAGTTCCAGCATCCTTCTCATGAACTTTTGAAGGAAAATGGCTTTACCCAACAAGTGTACCACAAGTATCG
TCGAAGATGCCTAAGTGAGAGAAAACGCTTGGGAATTGGTCAGTCCCAAGAAATGAATACCCTCTTTCGTTTCTGGTCCTTTTTCCTCAG
AGATCACTTCAATAAAAAAATGTATGAGGAATTTAGACAACTTGCTTGGGAAGATGCAAAAGAAAATTACAGGTATGGGTTAGAATGTCT
GTTCAGGTTTTATAGTTATGGACTGGAAAAAAAATTCAGGCGAGAAATTTTTCAGGATTTCCAAGAAGAAACCAAAAAAGACTACGAATC
TGGTCAGCTGTATGGACTAGAAAAGTTTTGGGCTTATTTGAAATATTCTCAATCTAAGACACAGTCTATTGACCCAAAACTTCAGGAATA
CCTCTGTAGTTTTAAGAGGTTAGAAGACTTCCGTGTTGATCCCCCTATTAGTGATGAATTTGGAAGAAAAAGACATTCCTCTACTTCTGG
TGAGGAGAGTAATCGTCATAGACTTCCACCTAATTCCTCTACAAAGCCACCAAATGCTGCTAAACCTACATCTACCAGTGAGCTTCAGGT
ACCAATAAACTCTCCCAGAAGGAATATTTCACCGGAGTCCAGTGACAATTCACATTAAACAGTGCTGCCTGTGTCCTGTGGTCTCAAGAA
ATGGTGAAATGCCTGAGAAATAGACTCTTATGAAAGTTCTTTGTCCTTGAAGTCAACATTTACATCAGTATTTATTTGGGGAAAATCTTC
TGGTGTTTAATTGTGATAATAAGAAAGAAGAAAAAGAAAGAAAAGTGGTAGCATTTTTTCTAACAAGATAAATTCTAAAAATGTTTTCCC
TGATTTCACAAACAAGGATAGTCTTGGTGACCTTTTATAGAGATCTTCTAGTAATGTATTTTGATCTCAGATTTCTTTTTCAAAGCCATG
GTTTTACAAAAACAGCATTCCTTAAATATATTTAAAAAACAATACAAGGAATGCCTAACATTTCAGCTCATACTTCTTAAAGAAGATATA
GTATGTTGTATTCTCTTCTTAGAGCTTTCTTAAAGAATCCACAATCCAATTACCCCACTGTCAATTCATATTTGAACTTACCAAAACAAA
GGAGGATTACGTATATGTTTTTTAAATTCAAAAAAGAATATGAAATTATACCTTTAGTATCCCTTTGAGACATATAGTTTAAAGAAAACT
TTTTTTAAAACAAAAGTAGGAATATATAGTAAGATTGTAGTTACAATGAGTATATGCACTTTTGATGCTAGGTTTTGCTTTTCTCCCCCC
AGTCATATCTCATGATTTCCACAGTTGTTGTATTGGTGTGGAGTTTTCTGAATTGGCTATAAGCTGATTACATATTAGAGGTTTATTTTT
ATGATTCTATATAAACGTGCACGAGTAATTTAAAACCTGCATTGGGATTGATTGGAATATTGTCCTAAATTAATTAAATCTTGCACTGTT
TTGAATGCATCTGCTATTTATACATCTGCAAGTGGGTATGTCATAAGGAGTCAGATTATCTTTAATTTAAAATGAATACTTAGTTTTACC
TTTTTGTTTATTTTTTGTTTAATTTTGTTTTTATAAATGTTTTCAAGAGTTATAGCAAATTGATTTCTAATTTTTATTGCTATTACAACT
GATGTAAATGGTAGTTTCAGTTTTTGTGAGATTTAAAAAAATAAAGCACTTATTCTGAATTTTTTGAATTGATTTTTAATTATTTTTATT
TAGAATATAGTTGAAAAGCTGTAATATTCAGTTTTGCTAGTAAAAGACCATTTTTTTGTGTGAATGAAGTTTCAATTATAAACTTACATT
CACTTTATTGAGCACTACATAATTTACAGATATTTTGTTGTATTGGCAAAAGCAAGTGGTTTCCATATGCTAAATTAATTGTATTTTCTT
TTTGAGCAGATTGGATATCTTGTTCTTATAAATTATAATATTGAAATACATATAATCTTTGGATGGATGGGCTGTTAATTTGTAAATAGG
TTTTCATTAAGTTATTTCTCATGATAAGTAATAATCAGCAGTTTTATAATATTTACTATTTGGAGGGTCATTTTGATGCTTTAAATTGCA
GAAATAGTCAAATTTGAATATTCAGAAAATAAATTTATTTAGATATATTGTAAAGAGGGTGCAAAACAAGCAATGGGTTAGAATAATAGA
TCTTCAAGTCTTTTCTTAAATGGGGTATGTAGTTCCAGCTTTTCAGTGAGAAATTTCCAAACCGTGCTTATTAGCTTTAAATGGTCTCTT
GAAATGATCATAAATTTTTCTCAGTGTCCTTTTTGTGTTGAACACATATATCTGAAACCTGTATTTAACCAGATATTTCTACTCAACTGA
ATATACAAGTGTAAATTTGATTGGAAAATTGTATATTATAAATGAAAATACAATAATCAGGAGTTTTGTGGTTTGTATTAATTAGTAGTT
TTATCATATTTTTATTATAAAAGTAATACATGTACATTGGGAAATTTAGAAAAGCACAAAGAAGAAAATAAAGTACTTGTTATAAAAAGA

>97209_97209_2_USP14-LARP1B_USP14_chr18_166819_ENST00000261601_LARP1B_chr4_129028293_ENST00000326639_length(amino acids)=734AA_BP=85
MLLVPVPLPPSSGPALLRRRLPPRPAMPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIK
NALKDSTEVEIVDEKMRKKIEPEKWPIPGPPPRSVPPTDFSQLIDCPEFVPGQAFCSHTESAPNSPRIGSPLSPKKNSETSILQAMSRGL
STSLPDLDSEPWIEVKKRHQPAPVKLRESVSVPEGSLNQLCSSEEPEQEELDFLFDEEIEQIGRKNTFTDWSDNDSDYEIDDQDLNKILI
VTQTPPYVKKHPGGDRTGTHMSRAKITSELAKVINDGLYYYEQDLWMEEDENKHTAIKQEVENFKKLNLISKEQFENLTPELPFEPNQEV
PVAPSQSRQGGVQGVLHIPKKDLTDELAQKLFDVSEITSAAMVHSLPTAVPESPRIHPTRTPKTPRTPRLQDPNKTPRFYPVVKEPKAID
VKSPRKRKTRHSTNPPLECHVGWVMDSRDRGPGTSSVSTSNASPSEGAPLAGSYGCTPHSFPKFQHPSHELLKENGFTQQVYHKYRRRCL
SERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFRQLAWEDAKENYRYGLECLFRFYSYGLEKKFRREIFQDFQEETKKDYESGQLY
GLEKFWAYLKYSQSKTQSIDPKLQEYLCSFKRLEDFRVDPPISDEFGRKRHSSTSGEESNRHRLPPNSSTKPPNAAKPTSTSELQVPINS

--------------------------------------------------------------
>97209_97209_3_USP14-LARP1B_USP14_chr18_166819_ENST00000261601_LARP1B_chr4_129028293_ENST00000441387_length(transcript)=3187nt_BP=286nt
GCCGCCGCCGCAGCTGCTCCTGGTCCCCGTCCCTTTGCCGCCCTCGTCAGGCCCAGCTCTCCTGCGCCGCCGCCTCCCGCCGCGCCCCGC
CATGCCGCTCTACTCCGTTACTGTAAAATGGGGAAAGGAGAAATTTGAAGGTGTAGAATTGAATACAGATGAACCTCCAATGGTATTCAA
GGCTCAGCTGTTTGCGTTGACTGGAGTCCAGCCTGCCAGACAGAAAGTTATGGTGAAAGGAGGAACGCTAAAGGATGATGATTGGGGAAA
CATCAAAATAAAAAATGCACTGAAGGATAGCACAGAAGTAGAAATTGTGGATGAGAAAATGAGAAAAAAGATAGAACCAGAAAAATGGCC
AATTCCAGGCCCTCCTCCACGCAGTGTGCCACCAACAGACTTCTCTCAACTGATTGATTGTCCAGAGTTTGTACCAGGCCAAGCCTTTTG
CTCACATACAGAGTCTGCCCCAAATTCTCCAAGAATTGGAAGCCCATTGAGCCCAAAGAAAAACAGTGAAACAAGTATTCTTCAAGCAAT
GTCTAGAGGTTTGTCTACCAGTTTGCCTGACTTGGACTCAGAACCTTGGATAGAAGTTAAAAAAAGACATCAGCCAGCCCCAGTGAAATT
GAGGGAATCAGTGTCTGTCCCTGAAGGGTCATTAAATCAGCTATGTTCTTCAGAAGAACCAGAACAAGAAGAACTTGATTTTTTGTTTGA
TGAAGAGATTGAACAAATAGGACGAAAAAACACATTTACTGATTGGTCTGATAATGATTCAGATTATGAAATTGATGACCAAGACTTAAA
CAAGATTTTGATTGTAACTCAGACACCACCTTATGTGAAAAAACATCCTGGAGGAGATCGAACAGGCACCCACATGTCTCGGGCAAAAAT
CACATCTGAACTTGCTAAAGTTATCAATGATGGCTTATACTATTATGAACAGGATCTATGGATGGAAGAAGATGAAAACAAACACACAGC
CATAAAGCAAGAAGTTGAGAACTTTAAGAAGCTAAATCTCATTAGTAAAGAGCAGTTTGAAAACCTAACACCTGAACTTCCTTTTGAGCC
AAACCAAGAAGTTCCTGTAGCACCTTCACAGTCCAGGCAAGGAGGTGTTCAAGGAGTGCTTCACATTCCCAAGAAAGATTTGACTGATGA
ATTAGCTCAGAAGTTATTTGATGTTTCAGAAATAACTTCAGCAGCAATGGTTCATTCGTTGCCTACAGCAGTTCCAGAATCTCCTAGAAT
TCATCCTACAAGAACACCCAAAACACCTCGAACACCTAGGTTACAAGATCCTAACAAAACACCAAGATTTTATCCTGTTGTTAAAGAACC
AAAAGCCATTGATGTAAAGAGTCCAAGAAAGAGAAAAACAAGGCATAGCACAAATCCCCCTCTAGAGTGTCATGTTGGTTGGGTAATGGA
TTCCAGAGACCGTGGGCCAGGAACATCCTCTGTCAGCACTTCAAATGCTTCACCTTCAGAAGGCGCACCACTAGCAGGAAGTTATGGATG
TACTCCTCATTCATTCCCAAAGTTCCAGCATCCTTCTCATGAACTTTTGAAGGAAAATGGCTTTACCCAACAAGTGTACCACAAGTATCG
TCGAAGATGCCTAAGTGAGAGAAAACGCTTGGGAATTGGTCAGTCCCAAGAAATGAATACCCTCTTTCGTTTCTGGTCCTTTTTCCTCAG
AGATCACTTCAATAAAAAAATGTATGAGGAATTTAGACAACTTGCTTGGGAAGATGCAAAAGAAAATTACAGGTCAGCTGTATGGACTAG
AAAAGTTTTGGGCTTATTTGAAATATTCTCAATCTAAGACACAGTCTATTGACCCAAAACTTCAGGAATACCTCTGTAGTTTTAAGAGGT
TAGAAGACTTCCGTGTTGATCCCCCTATTAGTGATGAATTTGGAAGAAAAAGACATTCCTCTACTTCTGGTGAGGAGAGTAATCGTCATA
GACTTCCACCTAATTCCTCTACAAAGCCACCAAATGCTGCTAAACCTACATCTACCAGTGAGCTTCAGGTACCAATAAACTCTCCCAGAA
GGAATATTTCACCGGAGTCCAGTGACAATTCACATTAAACAGTGCTGCCTGTGTCCTGTGGTCTCAAGAAATGGTGAAATGCCTGAGAAA
TAGACTCTTATGAAAGTTCTTTGTCCTTGAAGTCAACATTTACATCAGTATTTATTTGGGGAAAATCTTCTGGTGTTTAATTGTGATAAT
AAGAAAGAAGAAAAAGAAAGAAAAGTGGTAGCATTTTTTCTAACAAGATAAATTCTAAAAATGTTTTCCCTGATTTCACAAACAAGGATA
GTCTTGGTGACCTTTTATAGAGATCTTCTAGTAATGTATTTTGATCTCAGATTTCTTTTTCAAAGCCATGGTTTTACAAAAACAGCATTC
CTTAAATATATTTAAAAAACAATACAAGGAATGCCTAACATTTCAGCTCATACTTCTTAAAGAAGATATAGTATGTTGTATTCTCTTCTT
AGAGCTTTCTTAAAGAATCCACAATCCAATTACCCCACTGTCAATTCATATTTGAACTTACCAAAACAAAGGAGGATTACGTATATGTTT
TTTAAATTCAAAAAAGAATATGAAATTATACCTTTAGTATCCCTTTGAGACATATAGTTTAAAGAAAACTTTTTTTAAAACAAAAGTAGG
AATATATAGTAAGATTGTAGTTACAATGAGTATATGCACTTTTGATGCTAGGTTTTGCTTTTCTCCCCCCAGTCATATCTCATGATTTCC
ACAGTTGTTGTATTGGTGTGGAGTTTTCTGAATTGGCTATAAGCTGATTACATATTAGAGGTTTATTTTTATGATTCTATATAAACGTGC
ACGAGTAATTTAAAACCTGCATTGGGATTGATTGGAATATTGTCCTAAATTAATTAAATCTTGCACTGTTTTGAATGCATCTGCTATTTA
TACATCTGCAAGTGGGTATGTCATAAGGAGTCAGATTATCTTTAATTTAAAATGAATACTTAGTTTTACCTTTTTGTTTATTTTTTGTTT
AATTTTGTTTTTATAAATGTTTTCAAGAGTTATAGCAAATTGATTTCTAATTTTTATTGCTATTACAACTGATGTAAATGGTAGTTTCAG

>97209_97209_3_USP14-LARP1B_USP14_chr18_166819_ENST00000261601_LARP1B_chr4_129028293_ENST00000441387_length(amino acids)=607AA_BP=85
MLLVPVPLPPSSGPALLRRRLPPRPAMPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIK
NALKDSTEVEIVDEKMRKKIEPEKWPIPGPPPRSVPPTDFSQLIDCPEFVPGQAFCSHTESAPNSPRIGSPLSPKKNSETSILQAMSRGL
STSLPDLDSEPWIEVKKRHQPAPVKLRESVSVPEGSLNQLCSSEEPEQEELDFLFDEEIEQIGRKNTFTDWSDNDSDYEIDDQDLNKILI
VTQTPPYVKKHPGGDRTGTHMSRAKITSELAKVINDGLYYYEQDLWMEEDENKHTAIKQEVENFKKLNLISKEQFENLTPELPFEPNQEV
PVAPSQSRQGGVQGVLHIPKKDLTDELAQKLFDVSEITSAAMVHSLPTAVPESPRIHPTRTPKTPRTPRLQDPNKTPRFYPVVKEPKAID
VKSPRKRKTRHSTNPPLECHVGWVMDSRDRGPGTSSVSTSNASPSEGAPLAGSYGCTPHSFPKFQHPSHELLKENGFTQQVYHKYRRRCL

--------------------------------------------------------------
>97209_97209_4_USP14-LARP1B_USP14_chr18_166819_ENST00000582707_LARP1B_chr4_129028293_ENST00000264584_length(transcript)=3486nt_BP=511nt
CCCTCACTTGCTCCCTCCTTCCTTCCCGCCACCCCTCCACCGCCTTCCCCCTCCTCCCTCCTCTCGCCACCTCTAGGCCCCGCCCCGGTC
CTGCCGCCCAGTCTCCTCGCTGCAGTCGCTCCGGAGCTGCACGGGTGTTTTGCGTGTTGCTGCGTCATCGCCAGTGGCCGGTTTGAATGA
GACTCGTCGCACCGAAGCCGCCGCCACCACCGCGCCTCCGCCTCGGCCGCCGCCGCAGCTGCTCCTGGTCCCCGTCCCTTTGCCGCCCTC
GTCAGGCCCAGCTCTCCTGCGCCGCCGCCTCCCGCCGCGCCCCGCCATGCCGCTCTACTCCGTTACTGTAAAATGGGGAAAGGAGAAATT
TGAAGGTGTAGAATTGAATACAGATGAACCTCCAATGGTATTCAAGGCTCAGCTGTTTGCGTTGACTGGAGTCCAGCCTGCCAGACAGAA
AGTTATGGTGAAAGGAGGAACGCTAAAGGATGATGATTGGGGAAACATCAAAATAAAAAATGCACTGAAGGATAGCACAGAAGTAGAAAT
TGTGGATGAGAAAATGAGAAAAAAGATAGAACCAGAAAAATGGCCAATTCCAGGCCCTCCTCCACGCAGTGTGCCACCAACAGACTTCTC
TCAACTGATTGATTGTCCAGAGTTTGTACCAGGCCAAGCCTTTTGCTCACATACAGAGTCTGCCCCAAATTCTCCAAGAATTGGAAGCCC
ATTGAGCCCAAAGAAAAACAGTGAAACAAGTATTCTTCAAGCAATGTCTAGAGGTTTGTCTACCAGTTTGCCTGACTTGGACTCAGAACC
TTGGATAGAAGTTAAAAAAAGACATCAGCCAGCCCCAGTGAAATTGAGGGAATCAGTGTCTGTCCCTGAAGGGTCATTAAATCAGCTATG
TTCTTCAGAAGAACCAGAACAAGAAGAACTTGATTTTTTGTTTGATGAAGAGATTGAACAAATAGGACGAAAAAACACATTTACTGATTG
GTCTGATAATGATTCAGATTATGAAATTGATGACCAAGACTTAAACAAGATTTTGATTGTAACTCAGACACCACCTTATGTGAAAAAACA
TCCTGGAGGAGATCGAACAGGCACCCACATGTCTCGGGCAAAAATCACATCTGAACTTGCTAAAGTTATCAATGATGGCTTATACTATTA
TGAACAGGATCTATGGATGGAAGAAGATGAAAACAAACACACAGCCATAAAGCAAGAAGTTGAGAACTTTAAGAAGCTAAATCTCATTAG
TAAAGAGCAGTTTGAAAACCTAACACCTGAACTTCCTTTTGAGCCAAACCAAGAAGTTCCTGTAGCACCTTCACAGTCCAGGCAAGATTT
GACTGATGAATTAGCTCAGAAGTTATTTGATGTTTCAGAAATAACTTCAGCAGCAATGGTTCATTCGTTGCCTACAGCAGTTCCAGAATC
TCCTAGAATTCATCCTACAAGAACACCCAAAACACCTCGAACACCTAGGTTACAAGATCCTAACAAAACACCAAGATTTTATCCTGTTGT
TAAAGAACCAAAAGCCATTGATGTAAAGAGTCCAAGAAAGAGAAAAACAAGGCATAGCACAAATCCCCCTCTAGAGTGTCATGTTGGTTG
GGTAATGGATTCCAGAGACCGTGGGCCAGGAACATCCTCTGTCAGCACTTCAAATGCTTCACCTTCAGAAGGCGCACCACTAGCAGGAAG
TTATGGATGTACTCCTCATTCATTCCCAAAGTTCCAGCATCCTTCTCATGAACTTTTGAAGGAAAATGGCTTTACCCAACAAGTGTACCA
CAAGTATCGTCGAAGATGCCTAAGTGAGAGAAAACGCTTGGGAATTGGTCAGTCCCAAGAAATGAATACCCTCTTTCGTTTCTGGTCCTT
TTTCCTCAGAGATCACTTCAATAAAAAAATGTATGAGGAATTTAGACAACTTGCTTGGGAAGATGCAAAAGAAAATTACAGGTATGGGTT
AGAATGTCTGTTCAGGTTTTATAGTTATGGACTGGAAAAAAAATTCAGGCGAGAAATTTTTCAGGATTTCCAAGAAGAAACCAAAAAAGA
CTACGAATCTGGTCAGCTGTATGGACTAGAAAAGTTTTGGGCTTATTTGAAATATTCTCAATCTAAGACACAGTCTATTGACCCAAAACT
TCAGGAATACCTCTGTAGTTTTAAGAGGTTAGAAGACTTCCGTGTTGATCCCCCTATTAGTGATGAATTTGGAAGAAAAAGACATTCCTC
TACTTCTGGTGAGGAGAGTAATCGTCATAGACTTCCACCTAATTCCTCTACAAAGCCACCAAATGCTGCTAAACCTACATCTACCAGTGA
GCTTCAGGTACCAATAAACTCTCCCAGAAGGAATATTTCACCGGAGTCCAGTGACAATTCACATTAAACAGTGCTGCCTGTGTCCTGTGG
TCTCAAGAAATGGTGAAATGCCTGAGAAATAGACTCTTATGAAAGTTCTTTGTCCTTGAAGTCAACATTTACATCAGTATTTATTTGGGG
AAAATCTTCTGGTGTTTAATTGTGATAATAAGAAAGAAGAAAAAGAAAGAAAAGTGGTAGCATTTTTTCTAACAAGATAAATTCTAAAAA
TGTTTTCCCTGATTTCACAAACAAGGATAGTCTTGGTGACCTTTTATAGAGATCTTCTAGTAATGTATTTTGATCTCAGATTTCTTTTTC
AAAGCCATGGTTTTACAAAAACAGCATTCCTTAAATATATTTAAAAAACAATACAAGGAATGCCTAACATTTCAGCTCATACTTCTTAAA
GAAGATATAGTATGTTGTATTCTCTTCTTAGAGCTTTCTTAAAGAATCCACAATCCAATTACCCCACTGTCAATTCATATTTGAACTTAC
CAAAACAAAGGAGGATTACGTATATGTTTTTTAAATTCAAAAAAGAATATGAAATTATACCTTTAGTATCCCTTTGAGACATATAGTTTA
AAGAAAACTTTTTTTAAAACAAAAGTAGGAATATATAGTAAGATTGTAGTTACAATGAGTATATGCACTTTTGATGCTAGGTTTTGCTTT
TCTCCCCCCAGTCATATCTCATGATTTCCACAGTTGTTGTATTGGTGTGGAGTTTTCTGAATTGGCTATAAGCTGATTACATATTAGAGG
TTTATTTTTATGATTCTATATAAACGTGCACGAGTAATTTAAAACCTGCATTGGGATTGATTGGAATATTGTCCTAAATTAATTAAATCT
TGCACTGTTTTGAATGCATCTGCTATTTATACATCTGCAAGTGGGTATGTCATAAGGAGTCAGATTATCTTTAATTTAAAATGAATACTT
AGTTTTACCTTTTTGTTTATTTTTTGTTTAATTTTGTTTTTATAAATGTTTTCAAGAGTTATAGCAAATTGATTTCTAATTTTTATTGCT

>97209_97209_4_USP14-LARP1B_USP14_chr18_166819_ENST00000582707_LARP1B_chr4_129028293_ENST00000264584_length(amino acids)=765AA_BP=128
MQSLRSCTGVLRVAASSPVAGLNETRRTEAAATTAPPPRPPPQLLLVPVPLPPSSGPALLRRRLPPRPAMPLYSVTVKWGKEKFEGVELN
TDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNALKDSTEVEIVDEKMRKKIEPEKWPIPGPPPRSVPPTDFSQLIDCP
EFVPGQAFCSHTESAPNSPRIGSPLSPKKNSETSILQAMSRGLSTSLPDLDSEPWIEVKKRHQPAPVKLRESVSVPEGSLNQLCSSEEPE
QEELDFLFDEEIEQIGRKNTFTDWSDNDSDYEIDDQDLNKILIVTQTPPYVKKHPGGDRTGTHMSRAKITSELAKVINDGLYYYEQDLWM
EEDENKHTAIKQEVENFKKLNLISKEQFENLTPELPFEPNQEVPVAPSQSRQDLTDELAQKLFDVSEITSAAMVHSLPTAVPESPRIHPT
RTPKTPRTPRLQDPNKTPRFYPVVKEPKAIDVKSPRKRKTRHSTNPPLECHVGWVMDSRDRGPGTSSVSTSNASPSEGAPLAGSYGCTPH
SFPKFQHPSHELLKENGFTQQVYHKYRRRCLSERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFRQLAWEDAKENYRYGLECLFRF
YSYGLEKKFRREIFQDFQEETKKDYESGQLYGLEKFWAYLKYSQSKTQSIDPKLQEYLCSFKRLEDFRVDPPISDEFGRKRHSSTSGEES

--------------------------------------------------------------
>97209_97209_5_USP14-LARP1B_USP14_chr18_166819_ENST00000582707_LARP1B_chr4_129028293_ENST00000326639_length(transcript)=4378nt_BP=511nt
CCCTCACTTGCTCCCTCCTTCCTTCCCGCCACCCCTCCACCGCCTTCCCCCTCCTCCCTCCTCTCGCCACCTCTAGGCCCCGCCCCGGTC
CTGCCGCCCAGTCTCCTCGCTGCAGTCGCTCCGGAGCTGCACGGGTGTTTTGCGTGTTGCTGCGTCATCGCCAGTGGCCGGTTTGAATGA
GACTCGTCGCACCGAAGCCGCCGCCACCACCGCGCCTCCGCCTCGGCCGCCGCCGCAGCTGCTCCTGGTCCCCGTCCCTTTGCCGCCCTC
GTCAGGCCCAGCTCTCCTGCGCCGCCGCCTCCCGCCGCGCCCCGCCATGCCGCTCTACTCCGTTACTGTAAAATGGGGAAAGGAGAAATT
TGAAGGTGTAGAATTGAATACAGATGAACCTCCAATGGTATTCAAGGCTCAGCTGTTTGCGTTGACTGGAGTCCAGCCTGCCAGACAGAA
AGTTATGGTGAAAGGAGGAACGCTAAAGGATGATGATTGGGGAAACATCAAAATAAAAAATGCACTGAAGGATAGCACAGAAGTAGAAAT
TGTGGATGAGAAAATGAGAAAAAAGATAGAACCAGAAAAATGGCCAATTCCAGGCCCTCCTCCACGCAGTGTGCCACCAACAGACTTCTC
TCAACTGATTGATTGTCCAGAGTTTGTACCAGGCCAAGCCTTTTGCTCACATACAGAGTCTGCCCCAAATTCTCCAAGAATTGGAAGCCC
ATTGAGCCCAAAGAAAAACAGTGAAACAAGTATTCTTCAAGCAATGTCTAGAGGTTTGTCTACCAGTTTGCCTGACTTGGACTCAGAACC
TTGGATAGAAGTTAAAAAAAGACATCAGCCAGCCCCAGTGAAATTGAGGGAATCAGTGTCTGTCCCTGAAGGGTCATTAAATCAGCTATG
TTCTTCAGAAGAACCAGAACAAGAAGAACTTGATTTTTTGTTTGATGAAGAGATTGAACAAATAGGACGAAAAAACACATTTACTGATTG
GTCTGATAATGATTCAGATTATGAAATTGATGACCAAGACTTAAACAAGATTTTGATTGTAACTCAGACACCACCTTATGTGAAAAAACA
TCCTGGAGGAGATCGAACAGGCACCCACATGTCTCGGGCAAAAATCACATCTGAACTTGCTAAAGTTATCAATGATGGCTTATACTATTA
TGAACAGGATCTATGGATGGAAGAAGATGAAAACAAACACACAGCCATAAAGCAAGAAGTTGAGAACTTTAAGAAGCTAAATCTCATTAG
TAAAGAGCAGTTTGAAAACCTAACACCTGAACTTCCTTTTGAGCCAAACCAAGAAGTTCCTGTAGCACCTTCACAGTCCAGGCAAGGAGG
TGTTCAAGGAGTGCTTCACATTCCCAAGAAAGATTTGACTGATGAATTAGCTCAGAAGTTATTTGATGTTTCAGAAATAACTTCAGCAGC
AATGGTTCATTCGTTGCCTACAGCAGTTCCAGAATCTCCTAGAATTCATCCTACAAGAACACCCAAAACACCTCGAACACCTAGGTTACA
AGATCCTAACAAAACACCAAGATTTTATCCTGTTGTTAAAGAACCAAAAGCCATTGATGTAAAGAGTCCAAGAAAGAGAAAAACAAGGCA
TAGCACAAATCCCCCTCTAGAGTGTCATGTTGGTTGGGTAATGGATTCCAGAGACCGTGGGCCAGGAACATCCTCTGTCAGCACTTCAAA
TGCTTCACCTTCAGAAGGCGCACCACTAGCAGGAAGTTATGGATGTACTCCTCATTCATTCCCAAAGTTCCAGCATCCTTCTCATGAACT
TTTGAAGGAAAATGGCTTTACCCAACAAGTGTACCACAAGTATCGTCGAAGATGCCTAAGTGAGAGAAAACGCTTGGGAATTGGTCAGTC
CCAAGAAATGAATACCCTCTTTCGTTTCTGGTCCTTTTTCCTCAGAGATCACTTCAATAAAAAAATGTATGAGGAATTTAGACAACTTGC
TTGGGAAGATGCAAAAGAAAATTACAGGTATGGGTTAGAATGTCTGTTCAGGTTTTATAGTTATGGACTGGAAAAAAAATTCAGGCGAGA
AATTTTTCAGGATTTCCAAGAAGAAACCAAAAAAGACTACGAATCTGGTCAGCTGTATGGACTAGAAAAGTTTTGGGCTTATTTGAAATA
TTCTCAATCTAAGACACAGTCTATTGACCCAAAACTTCAGGAATACCTCTGTAGTTTTAAGAGGTTAGAAGACTTCCGTGTTGATCCCCC
TATTAGTGATGAATTTGGAAGAAAAAGACATTCCTCTACTTCTGGTGAGGAGAGTAATCGTCATAGACTTCCACCTAATTCCTCTACAAA
GCCACCAAATGCTGCTAAACCTACATCTACCAGTGAGCTTCAGGTACCAATAAACTCTCCCAGAAGGAATATTTCACCGGAGTCCAGTGA
CAATTCACATTAAACAGTGCTGCCTGTGTCCTGTGGTCTCAAGAAATGGTGAAATGCCTGAGAAATAGACTCTTATGAAAGTTCTTTGTC
CTTGAAGTCAACATTTACATCAGTATTTATTTGGGGAAAATCTTCTGGTGTTTAATTGTGATAATAAGAAAGAAGAAAAAGAAAGAAAAG
TGGTAGCATTTTTTCTAACAAGATAAATTCTAAAAATGTTTTCCCTGATTTCACAAACAAGGATAGTCTTGGTGACCTTTTATAGAGATC
TTCTAGTAATGTATTTTGATCTCAGATTTCTTTTTCAAAGCCATGGTTTTACAAAAACAGCATTCCTTAAATATATTTAAAAAACAATAC
AAGGAATGCCTAACATTTCAGCTCATACTTCTTAAAGAAGATATAGTATGTTGTATTCTCTTCTTAGAGCTTTCTTAAAGAATCCACAAT
CCAATTACCCCACTGTCAATTCATATTTGAACTTACCAAAACAAAGGAGGATTACGTATATGTTTTTTAAATTCAAAAAAGAATATGAAA
TTATACCTTTAGTATCCCTTTGAGACATATAGTTTAAAGAAAACTTTTTTTAAAACAAAAGTAGGAATATATAGTAAGATTGTAGTTACA
ATGAGTATATGCACTTTTGATGCTAGGTTTTGCTTTTCTCCCCCCAGTCATATCTCATGATTTCCACAGTTGTTGTATTGGTGTGGAGTT
TTCTGAATTGGCTATAAGCTGATTACATATTAGAGGTTTATTTTTATGATTCTATATAAACGTGCACGAGTAATTTAAAACCTGCATTGG
GATTGATTGGAATATTGTCCTAAATTAATTAAATCTTGCACTGTTTTGAATGCATCTGCTATTTATACATCTGCAAGTGGGTATGTCATA
AGGAGTCAGATTATCTTTAATTTAAAATGAATACTTAGTTTTACCTTTTTGTTTATTTTTTGTTTAATTTTGTTTTTATAAATGTTTTCA
AGAGTTATAGCAAATTGATTTCTAATTTTTATTGCTATTACAACTGATGTAAATGGTAGTTTCAGTTTTTGTGAGATTTAAAAAAATAAA
GCACTTATTCTGAATTTTTTGAATTGATTTTTAATTATTTTTATTTAGAATATAGTTGAAAAGCTGTAATATTCAGTTTTGCTAGTAAAA
GACCATTTTTTTGTGTGAATGAAGTTTCAATTATAAACTTACATTCACTTTATTGAGCACTACATAATTTACAGATATTTTGTTGTATTG
GCAAAAGCAAGTGGTTTCCATATGCTAAATTAATTGTATTTTCTTTTTGAGCAGATTGGATATCTTGTTCTTATAAATTATAATATTGAA
ATACATATAATCTTTGGATGGATGGGCTGTTAATTTGTAAATAGGTTTTCATTAAGTTATTTCTCATGATAAGTAATAATCAGCAGTTTT
ATAATATTTACTATTTGGAGGGTCATTTTGATGCTTTAAATTGCAGAAATAGTCAAATTTGAATATTCAGAAAATAAATTTATTTAGATA
TATTGTAAAGAGGGTGCAAAACAAGCAATGGGTTAGAATAATAGATCTTCAAGTCTTTTCTTAAATGGGGTATGTAGTTCCAGCTTTTCA
GTGAGAAATTTCCAAACCGTGCTTATTAGCTTTAAATGGTCTCTTGAAATGATCATAAATTTTTCTCAGTGTCCTTTTTGTGTTGAACAC
ATATATCTGAAACCTGTATTTAACCAGATATTTCTACTCAACTGAATATACAAGTGTAAATTTGATTGGAAAATTGTATATTATAAATGA
AAATACAATAATCAGGAGTTTTGTGGTTTGTATTAATTAGTAGTTTTATCATATTTTTATTATAAAAGTAATACATGTACATTGGGAAAT

>97209_97209_5_USP14-LARP1B_USP14_chr18_166819_ENST00000582707_LARP1B_chr4_129028293_ENST00000326639_length(amino acids)=777AA_BP=128
MQSLRSCTGVLRVAASSPVAGLNETRRTEAAATTAPPPRPPPQLLLVPVPLPPSSGPALLRRRLPPRPAMPLYSVTVKWGKEKFEGVELN
TDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNALKDSTEVEIVDEKMRKKIEPEKWPIPGPPPRSVPPTDFSQLIDCP
EFVPGQAFCSHTESAPNSPRIGSPLSPKKNSETSILQAMSRGLSTSLPDLDSEPWIEVKKRHQPAPVKLRESVSVPEGSLNQLCSSEEPE
QEELDFLFDEEIEQIGRKNTFTDWSDNDSDYEIDDQDLNKILIVTQTPPYVKKHPGGDRTGTHMSRAKITSELAKVINDGLYYYEQDLWM
EEDENKHTAIKQEVENFKKLNLISKEQFENLTPELPFEPNQEVPVAPSQSRQGGVQGVLHIPKKDLTDELAQKLFDVSEITSAAMVHSLP
TAVPESPRIHPTRTPKTPRTPRLQDPNKTPRFYPVVKEPKAIDVKSPRKRKTRHSTNPPLECHVGWVMDSRDRGPGTSSVSTSNASPSEG
APLAGSYGCTPHSFPKFQHPSHELLKENGFTQQVYHKYRRRCLSERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFRQLAWEDAKE
NYRYGLECLFRFYSYGLEKKFRREIFQDFQEETKKDYESGQLYGLEKFWAYLKYSQSKTQSIDPKLQEYLCSFKRLEDFRVDPPISDEFG

--------------------------------------------------------------
>97209_97209_6_USP14-LARP1B_USP14_chr18_166819_ENST00000582707_LARP1B_chr4_129028293_ENST00000441387_length(transcript)=3412nt_BP=511nt
CCCTCACTTGCTCCCTCCTTCCTTCCCGCCACCCCTCCACCGCCTTCCCCCTCCTCCCTCCTCTCGCCACCTCTAGGCCCCGCCCCGGTC
CTGCCGCCCAGTCTCCTCGCTGCAGTCGCTCCGGAGCTGCACGGGTGTTTTGCGTGTTGCTGCGTCATCGCCAGTGGCCGGTTTGAATGA
GACTCGTCGCACCGAAGCCGCCGCCACCACCGCGCCTCCGCCTCGGCCGCCGCCGCAGCTGCTCCTGGTCCCCGTCCCTTTGCCGCCCTC
GTCAGGCCCAGCTCTCCTGCGCCGCCGCCTCCCGCCGCGCCCCGCCATGCCGCTCTACTCCGTTACTGTAAAATGGGGAAAGGAGAAATT
TGAAGGTGTAGAATTGAATACAGATGAACCTCCAATGGTATTCAAGGCTCAGCTGTTTGCGTTGACTGGAGTCCAGCCTGCCAGACAGAA
AGTTATGGTGAAAGGAGGAACGCTAAAGGATGATGATTGGGGAAACATCAAAATAAAAAATGCACTGAAGGATAGCACAGAAGTAGAAAT
TGTGGATGAGAAAATGAGAAAAAAGATAGAACCAGAAAAATGGCCAATTCCAGGCCCTCCTCCACGCAGTGTGCCACCAACAGACTTCTC
TCAACTGATTGATTGTCCAGAGTTTGTACCAGGCCAAGCCTTTTGCTCACATACAGAGTCTGCCCCAAATTCTCCAAGAATTGGAAGCCC
ATTGAGCCCAAAGAAAAACAGTGAAACAAGTATTCTTCAAGCAATGTCTAGAGGTTTGTCTACCAGTTTGCCTGACTTGGACTCAGAACC
TTGGATAGAAGTTAAAAAAAGACATCAGCCAGCCCCAGTGAAATTGAGGGAATCAGTGTCTGTCCCTGAAGGGTCATTAAATCAGCTATG
TTCTTCAGAAGAACCAGAACAAGAAGAACTTGATTTTTTGTTTGATGAAGAGATTGAACAAATAGGACGAAAAAACACATTTACTGATTG
GTCTGATAATGATTCAGATTATGAAATTGATGACCAAGACTTAAACAAGATTTTGATTGTAACTCAGACACCACCTTATGTGAAAAAACA
TCCTGGAGGAGATCGAACAGGCACCCACATGTCTCGGGCAAAAATCACATCTGAACTTGCTAAAGTTATCAATGATGGCTTATACTATTA
TGAACAGGATCTATGGATGGAAGAAGATGAAAACAAACACACAGCCATAAAGCAAGAAGTTGAGAACTTTAAGAAGCTAAATCTCATTAG
TAAAGAGCAGTTTGAAAACCTAACACCTGAACTTCCTTTTGAGCCAAACCAAGAAGTTCCTGTAGCACCTTCACAGTCCAGGCAAGGAGG
TGTTCAAGGAGTGCTTCACATTCCCAAGAAAGATTTGACTGATGAATTAGCTCAGAAGTTATTTGATGTTTCAGAAATAACTTCAGCAGC
AATGGTTCATTCGTTGCCTACAGCAGTTCCAGAATCTCCTAGAATTCATCCTACAAGAACACCCAAAACACCTCGAACACCTAGGTTACA
AGATCCTAACAAAACACCAAGATTTTATCCTGTTGTTAAAGAACCAAAAGCCATTGATGTAAAGAGTCCAAGAAAGAGAAAAACAAGGCA
TAGCACAAATCCCCCTCTAGAGTGTCATGTTGGTTGGGTAATGGATTCCAGAGACCGTGGGCCAGGAACATCCTCTGTCAGCACTTCAAA
TGCTTCACCTTCAGAAGGCGCACCACTAGCAGGAAGTTATGGATGTACTCCTCATTCATTCCCAAAGTTCCAGCATCCTTCTCATGAACT
TTTGAAGGAAAATGGCTTTACCCAACAAGTGTACCACAAGTATCGTCGAAGATGCCTAAGTGAGAGAAAACGCTTGGGAATTGGTCAGTC
CCAAGAAATGAATACCCTCTTTCGTTTCTGGTCCTTTTTCCTCAGAGATCACTTCAATAAAAAAATGTATGAGGAATTTAGACAACTTGC
TTGGGAAGATGCAAAAGAAAATTACAGGTCAGCTGTATGGACTAGAAAAGTTTTGGGCTTATTTGAAATATTCTCAATCTAAGACACAGT
CTATTGACCCAAAACTTCAGGAATACCTCTGTAGTTTTAAGAGGTTAGAAGACTTCCGTGTTGATCCCCCTATTAGTGATGAATTTGGAA
GAAAAAGACATTCCTCTACTTCTGGTGAGGAGAGTAATCGTCATAGACTTCCACCTAATTCCTCTACAAAGCCACCAAATGCTGCTAAAC
CTACATCTACCAGTGAGCTTCAGGTACCAATAAACTCTCCCAGAAGGAATATTTCACCGGAGTCCAGTGACAATTCACATTAAACAGTGC
TGCCTGTGTCCTGTGGTCTCAAGAAATGGTGAAATGCCTGAGAAATAGACTCTTATGAAAGTTCTTTGTCCTTGAAGTCAACATTTACAT
CAGTATTTATTTGGGGAAAATCTTCTGGTGTTTAATTGTGATAATAAGAAAGAAGAAAAAGAAAGAAAAGTGGTAGCATTTTTTCTAACA
AGATAAATTCTAAAAATGTTTTCCCTGATTTCACAAACAAGGATAGTCTTGGTGACCTTTTATAGAGATCTTCTAGTAATGTATTTTGAT
CTCAGATTTCTTTTTCAAAGCCATGGTTTTACAAAAACAGCATTCCTTAAATATATTTAAAAAACAATACAAGGAATGCCTAACATTTCA
GCTCATACTTCTTAAAGAAGATATAGTATGTTGTATTCTCTTCTTAGAGCTTTCTTAAAGAATCCACAATCCAATTACCCCACTGTCAAT
TCATATTTGAACTTACCAAAACAAAGGAGGATTACGTATATGTTTTTTAAATTCAAAAAAGAATATGAAATTATACCTTTAGTATCCCTT
TGAGACATATAGTTTAAAGAAAACTTTTTTTAAAACAAAAGTAGGAATATATAGTAAGATTGTAGTTACAATGAGTATATGCACTTTTGA
TGCTAGGTTTTGCTTTTCTCCCCCCAGTCATATCTCATGATTTCCACAGTTGTTGTATTGGTGTGGAGTTTTCTGAATTGGCTATAAGCT
GATTACATATTAGAGGTTTATTTTTATGATTCTATATAAACGTGCACGAGTAATTTAAAACCTGCATTGGGATTGATTGGAATATTGTCC
TAAATTAATTAAATCTTGCACTGTTTTGAATGCATCTGCTATTTATACATCTGCAAGTGGGTATGTCATAAGGAGTCAGATTATCTTTAA
TTTAAAATGAATACTTAGTTTTACCTTTTTGTTTATTTTTTGTTTAATTTTGTTTTTATAAATGTTTTCAAGAGTTATAGCAAATTGATT

>97209_97209_6_USP14-LARP1B_USP14_chr18_166819_ENST00000582707_LARP1B_chr4_129028293_ENST00000441387_length(amino acids)=650AA_BP=128
MQSLRSCTGVLRVAASSPVAGLNETRRTEAAATTAPPPRPPPQLLLVPVPLPPSSGPALLRRRLPPRPAMPLYSVTVKWGKEKFEGVELN
TDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNALKDSTEVEIVDEKMRKKIEPEKWPIPGPPPRSVPPTDFSQLIDCP
EFVPGQAFCSHTESAPNSPRIGSPLSPKKNSETSILQAMSRGLSTSLPDLDSEPWIEVKKRHQPAPVKLRESVSVPEGSLNQLCSSEEPE
QEELDFLFDEEIEQIGRKNTFTDWSDNDSDYEIDDQDLNKILIVTQTPPYVKKHPGGDRTGTHMSRAKITSELAKVINDGLYYYEQDLWM
EEDENKHTAIKQEVENFKKLNLISKEQFENLTPELPFEPNQEVPVAPSQSRQGGVQGVLHIPKKDLTDELAQKLFDVSEITSAAMVHSLP
TAVPESPRIHPTRTPKTPRTPRLQDPNKTPRFYPVVKEPKAIDVKSPRKRKTRHSTNPPLECHVGWVMDSRDRGPGTSSVSTSNASPSEG
APLAGSYGCTPHSFPKFQHPSHELLKENGFTQQVYHKYRRRCLSERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFRQLAWEDAKE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for USP14-LARP1B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for USP14-LARP1B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for USP14-LARP1B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source