FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:USP15-DPY19L2 (FusionGDB2 ID:97222)

Fusion Gene Summary for USP15-DPY19L2

check button Fusion gene summary
Fusion gene informationFusion gene name: USP15-DPY19L2
Fusion gene ID: 97222
HgeneTgene
Gene symbol

USP15

DPY19L2

Gene ID

9958

283417

Gene nameubiquitin specific peptidase 15dpy-19 like 2
SynonymsUNPH-2|UNPH4SPATA34|SPGF9
Cytomap

12q14.1

12q14.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 15deubiquitinating enzyme 15ubiquitin thioesterase 15ubiquitin thiolesterase 15ubiquitin-specific-processing protease 15probable C-mannosyltransferase DPY19L2protein dpy-19 homolog 2spermatogenesis associated 34
Modification date2020031320200313
UniProtAcc.

Q6ZN68

Ensembl transtripts involved in fusion geneENST00000280377, ENST00000312635, 
ENST00000353364, ENST00000393654, 
ENST00000550632, 
ENST00000413230, 
ENST00000324472, 
Fusion gene scores* DoF score23 X 14 X 12=38645 X 8 X 4=160
# samples 266
** MAII scorelog2(26/3864*10)=-3.89351156580732
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/160*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP15 [Title/Abstract] AND DPY19L2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP15(62719714)-DPY19L2(63984907), # samples:2
USP15(62719714)-DPY19L2(63977616), # samples:2
Anticipated loss of major functional domain due to fusion event.USP15-DPY19L2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
USP15-DPY19L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP15

GO:0007179

transforming growth factor beta receptor signaling pathway

21947082

HgeneUSP15

GO:0016579

protein deubiquitination

16005295|22344298|27368102

HgeneUSP15

GO:0030509

BMP signaling pathway

21947082

HgeneUSP15

GO:0035520

monoubiquitinated protein deubiquitination

21947082|24399297

HgeneUSP15

GO:0035616

histone H2B conserved C-terminal lysine deubiquitination

24526689

HgeneUSP15

GO:1900246

positive regulation of RIG-I signaling pathway

24399297


check buttonFusion gene breakpoints across USP15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DPY19L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-HB-A3YV-01AUSP15chr12

62719714

-DPY19L2chr12

63977616

-
ChimerDB4SARCTCGA-HB-A3YV-01AUSP15chr12

62719714

+DPY19L2chr12

63984907

-
ChimerDB4SARCTCGA-X9-A971-01AUSP15chr12

62719714

+DPY19L2chr12

63964637

-
ChimerDB4SARCTCGA-X9-A971-01AUSP15chr12

62719714

+DPY19L2chr12

63977616

-
ChimerDB4SARCTCGA-X9-A971-01AUSP15chr12

62719714

+DPY19L2chr12

63984907

-


Top

Fusion Gene ORF analysis for USP15-DPY19L2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000280377ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63977616

-
5CDS-5UTRENST00000312635ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63977616

-
5CDS-5UTRENST00000353364ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63977616

-
5CDS-5UTRENST00000393654ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63977616

-
5CDS-intronENST00000280377ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63984907

-
5CDS-intronENST00000280377ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63984907

-
5CDS-intronENST00000312635ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63984907

-
5CDS-intronENST00000312635ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63984907

-
5CDS-intronENST00000353364ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63984907

-
5CDS-intronENST00000353364ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63984907

-
5CDS-intronENST00000393654ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63984907

-
5CDS-intronENST00000393654ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63984907

-
Frame-shiftENST00000280377ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63964637

-
Frame-shiftENST00000280377ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63964637

-
Frame-shiftENST00000312635ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63964637

-
Frame-shiftENST00000312635ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63964637

-
Frame-shiftENST00000353364ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63964637

-
Frame-shiftENST00000353364ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63964637

-
Frame-shiftENST00000393654ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63964637

-
Frame-shiftENST00000393654ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63964637

-
In-frameENST00000280377ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63977616

-
In-frameENST00000312635ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63977616

-
In-frameENST00000353364ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63977616

-
In-frameENST00000393654ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63977616

-
intron-3CDSENST00000550632ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63964637

-
intron-3CDSENST00000550632ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63977616

-
intron-3CDSENST00000550632ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63964637

-
intron-5UTRENST00000550632ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63977616

-
intron-intronENST00000550632ENST00000324472USP15chr12

62719714

+DPY19L2chr12

63984907

-
intron-intronENST00000550632ENST00000413230USP15chr12

62719714

+DPY19L2chr12

63984907

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000353364USP15chr1262719714+ENST00000324472DPY19L2chr1263977616-3056760771456459
ENST00000280377USP15chr1262719714+ENST00000324472DPY19L2chr1263977616-3037741581437459
ENST00000393654USP15chr1262719714+ENST00000324472DPY19L2chr1263977616-300070491400463
ENST00000312635USP15chr1262719714+ENST00000324472DPY19L2chr1263977616-2997701181397459

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000353364ENST00000324472USP15chr1262719714+DPY19L2chr1263977616-5.96E-050.9999404
ENST00000280377ENST00000324472USP15chr1262719714+DPY19L2chr1263977616-5.92E-050.99994075
ENST00000393654ENST00000324472USP15chr1262719714+DPY19L2chr1263977616-6.92E-050.99993074
ENST00000312635ENST00000324472USP15chr1262719714+DPY19L2chr1263977616-5.84E-050.9999416

Top

Fusion Genomic Features for USP15-DPY19L2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for USP15-DPY19L2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:62719714/chr12:63984907)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DPY19L2

Q6ZN68

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP15chr12:62719714chr12:63977616ENST00000280377+6227_118227982.0DomainDUSP
HgeneUSP15chr12:62719714chr12:63977616ENST00000312635+677_118227236.0DomainDUSP
HgeneUSP15chr12:62719714chr12:63977616ENST00000353364+6217_118227953.0DomainDUSP
TgeneDPY19L2chr12:62719714chr12:63977616ENST000003244721522534_554526759.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP15chr12:62719714chr12:63977616ENST00000280377+622289_933227982.0DomainUSP
HgeneUSP15chr12:62719714chr12:63977616ENST00000312635+67289_933227236.0DomainUSP
HgeneUSP15chr12:62719714chr12:63977616ENST00000353364+621289_933227953.0DomainUSP
TgeneDPY19L2chr12:62719714chr12:63977616ENST000003244721522108_128526759.0TransmembraneHelical
TgeneDPY19L2chr12:62719714chr12:63977616ENST000003244721522154_174526759.0TransmembraneHelical
TgeneDPY19L2chr12:62719714chr12:63977616ENST000003244721522195_215526759.0TransmembraneHelical
TgeneDPY19L2chr12:62719714chr12:63977616ENST000003244721522243_265526759.0TransmembraneHelical
TgeneDPY19L2chr12:62719714chr12:63977616ENST000003244721522269_286526759.0TransmembraneHelical
TgeneDPY19L2chr12:62719714chr12:63977616ENST000003244721522297_317526759.0TransmembraneHelical
TgeneDPY19L2chr12:62719714chr12:63977616ENST000003244721522344_364526759.0TransmembraneHelical
TgeneDPY19L2chr12:62719714chr12:63977616ENST000003244721522372_392526759.0TransmembraneHelical
TgeneDPY19L2chr12:62719714chr12:63977616ENST000003244721522423_443526759.0TransmembraneHelical
TgeneDPY19L2chr12:62719714chr12:63977616ENST000003244721522489_509526759.0TransmembraneHelical


Top

Fusion Gene Sequence for USP15-DPY19L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97222_97222_1_USP15-DPY19L2_USP15_chr12_62719714_ENST00000280377_DPY19L2_chr12_63977616_ENST00000324472_length(transcript)=3037nt_BP=741nt
ATGCTCTGGGGCGTGCCGCCGCCGTCGCTGCCACCTCCCCTACCGCTAGTGGAAGAAGATGGCGGAAGGCGGAGCGGCGGATCTGGACAC
CCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTCCGGAAAGGGGACACCTGGTACCTAGTCGATAGTCGCTGGTTCAAACAGTG
GAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAGATGGGAGATCAAAATGTGTATCCTGGACCCATTGATAACTCTGGACTTCT
CAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATTGATGAATTGGATTACATACTGTTGCCAACTGAAGGTTGGAATAAACTTGT
CAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCACGAAAGGTGGTTGAACAGGGTATGTTTGTAAAGCACTGCAAAGTAGAAGT
ATATCTCACAGAATTGAAGCTATGTGAAAATGGAAACATGAATAATGTTGTAACTCGAAGATTTAGCAAAGCTGACACAATAGATACAAT
TGAAAAGGAAATAAGAAAAATCTTCAGTATTCCAGATGAAAAGGAGACCAGATTGTGGAACAAATACATGAGTAACACATTTGAACCACT
GAATAAACCAGACAGCACCATTCAGGATGCTGGTTTATACCAAGGACAGGTATTAGTGATAGAACAGAAAAATGAAGATGGAACATGGCC
AAGGGGTCCTTCTACTCCTAAAAAACAGCTCCTTGAACACAGTGAGCTGGCTTTTCACACATTGCAGTTGTTAGTGTTTACTGCCCTTGC
CATTTTAATTATGAGGCTAAAGATGTTTTTGACACCGCACATGTGTGTTATGGCTTCCTTGATATGCTCTCGACAGCTCTTTGGCTGGCT
TTTTCGCAGAGTTCGTTTTGAGAAGGTTATCTTTGGCATTTTAACAGTGATGTCAATACAAGGTTATGCAAACCTCCGTAATCAATGGAG
CATAATAGGAGAATTTAATAATTTGCCTCAGGAAGAACTTTTACAGTGGATCAAATACAGTACCACATCAGATGCTGTCTTTGCAGGTGC
CATGCCTACAATGGCAAGCATCAAGCTGTCTACACTTCATCCCATTGTGAATCATCCACATTACGAAGATGCAGACTTGAGGGCTCGGAC
AAAAATAGTTTATTCTACATATAGTCGAAAATCTGCCAAAGAAGTAAGAGATAAATTGTTGGAGTTACATGTGAATTATTATGTTTTAGA
AGAGGCATGGTGTGTTGTGAGAACTAAGCCTGGTTGCAGTATGCTTGAAATCTGGGATGTGGAAGACCCTTCCAATGCAGCTAACCCTCC
CTTATGTAGCGTCCTGCTCGAAGACGCCAGGCCTTACTTCACCACAGTATTTCAGAATAGTGTGTACAGAGTATTAAAGGTTAACTGAGA
AGGATACTACCCATTTTACTATGGCACAATGCCGTGTGTCAAAAACAATCACCCTTTGGCTTATTCACATTAATAAAAATCACAAGCTTT
AATAACAGACACTTAAAAATAAGATAAAAATGGATTGGAAATTTTTCTGATTACTAAAAGGTAAATTACTTTTCTGTTCATTGAATGTCA
GCCTTATTAAGCTTGTCATATAAGTTATTAAATCATTCATGTCATACTGCATAAACAAATGTTCATTTCAGAATTTTAAAGAGAAATGTA
TATAAAAGAACAATGAATTTTAATAAATCAGGGGTATGTAAGTCCTTTTTCATCCAACTAGGTGAATTGCTTCAGATTTTCTCTAGTACC
AGAGGGTACCTCCTCAAACTCTTTGAACCACTTAAGGCAGAAGAATGCAAGCTCTGAAATGACATCCTTAAAATGCTGATACTGGTCACA
GCCTCTTTACCTCTGTGAGGAAATTGTAACAGTGTGTCTTTTAAGGTGTTTTTATTTTACCAGCCCTTAAGAAAGATCTCTAATACCTTT
TAATACTTTTTTTTAATAATTTCAAGTTGAAGTGTTTTTAAAAACACTTTGTTTTGTAATGTTTTGAATCTCTTGAGATGTGTTTACCCC
ACTAGATACATATTTGCCACTGGTTAGTTCTCCATCTAAGCTCAAGAGGTTATTCATCTCTCTTTAGATTCCAGTGGCTTTTCTTTTAAC
ATCCAGGTAAAACAGAAACTGCTATGGTATACAACCAAGTTTTGGGGTTAAACATAATCAGAAAAGAAAATCCAGTTAAATTTATGAAGT
GAGATTTTCAGATCCTAGATCTTGAATAAAGGAAAGGTCTTTTCATCTTGATGGCCCCAAAGCTTGTTGGTCATGGTCTTTATTTCTGGC
CACTATCTTCTTAAATAATATATTTTTAAGCCCTCATTTATTTTTGGTTTTGGGTGAGGAAAGTCATGTTTTCTAAGTCCTCTCCCCTAA
TAAAACCTACCCAACAATAGTGCTTTGAAAAGTGGTAGTTATCTTGAAGATACTCTTGCCAAATGCAAAGATAAACATTCTTTTTGTCTG
CTTTATAAATATGAAATATGCCAGATCTATAGTATTTTAATGTGCATCTACTTTAAATGAGTCATCTTGGGGTTTTTATAATTCCCTTAT
GTTCTTGCCCCTCTACACTTGAAATAACAAAATGCCTTAATTTTATGGATTAGTTCTCTTATAGTAGACAGGCAGCTATATGCAGCAAAA
CCAATAAAGTTATTTTTCAACTTTCATAGTTGTAAAATATCTTATAACAGAATACAAAACAGCTAAGAAAACATGCCACATTTTATTTTA
GCATTTTCAAATAATTTGTTTTTGGTGTAAGCACAGGATAAAAAAGGAGAGCGTCAAAGAAAAGAGACATAACACCTAACATTCATAAAA
ATTAACAAAGTATATTTTGGATGATGTTTTTACAGGAAATATTTTAAATAAGTTGGTAGAACTTTTAAAATGGTACTGTATTAGCTAATA

>97222_97222_1_USP15-DPY19L2_USP15_chr12_62719714_ENST00000280377_DPY19L2_chr12_63977616_ENST00000324472_length(amino acids)=459AA_BP=
MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI
LLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLW
NKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPKKQLLEHSELAFHTLQLLVFTALAILIMRLKMFLTPHMCVMAS
LICSRQLFGWLFRRVRFEKVIFGILTVMSIQGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTSDAVFAGAMPTMASIKLSTLHPIVNHP
HYEDADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLCSVLLEDARPYFTTVFQN

--------------------------------------------------------------
>97222_97222_2_USP15-DPY19L2_USP15_chr12_62719714_ENST00000312635_DPY19L2_chr12_63977616_ENST00000324472_length(transcript)=2997nt_BP=701nt
TACCGCTAGTGGAAGAAGATGGCGGAAGGCGGAGCGGCGGATCTGGACACCCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTC
CGGAAAGGGGACACCTGGTACCTAGTCGATAGTCGCTGGTTCAAACAGTGGAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAG
ATGGGAGATCAAAATGTGTATCCTGGACCCATTGATAACTCTGGACTTCTCAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATT
GATGAATTGGATTACATACTGTTGCCAACTGAAGGTTGGAATAAACTTGTCAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCA
CGAAAGGTGGTTGAACAGGGTATGTTTGTAAAGCACTGCAAAGTAGAAGTATATCTCACAGAATTGAAGCTATGTGAAAATGGAAACATG
AATAATGTTGTAACTCGAAGATTTAGCAAAGCTGACACAATAGATACAATTGAAAAGGAAATAAGAAAAATCTTCAGTATTCCAGATGAA
AAGGAGACCAGATTGTGGAACAAATACATGAGTAACACATTTGAACCACTGAATAAACCAGACAGCACCATTCAGGATGCTGGTTTATAC
CAAGGACAGGTATTAGTGATAGAACAGAAAAATGAAGATGGAACATGGCCAAGGGGTCCTTCTACTCCTAAAAAACAGCTCCTTGAACAC
AGTGAGCTGGCTTTTCACACATTGCAGTTGTTAGTGTTTACTGCCCTTGCCATTTTAATTATGAGGCTAAAGATGTTTTTGACACCGCAC
ATGTGTGTTATGGCTTCCTTGATATGCTCTCGACAGCTCTTTGGCTGGCTTTTTCGCAGAGTTCGTTTTGAGAAGGTTATCTTTGGCATT
TTAACAGTGATGTCAATACAAGGTTATGCAAACCTCCGTAATCAATGGAGCATAATAGGAGAATTTAATAATTTGCCTCAGGAAGAACTT
TTACAGTGGATCAAATACAGTACCACATCAGATGCTGTCTTTGCAGGTGCCATGCCTACAATGGCAAGCATCAAGCTGTCTACACTTCAT
CCCATTGTGAATCATCCACATTACGAAGATGCAGACTTGAGGGCTCGGACAAAAATAGTTTATTCTACATATAGTCGAAAATCTGCCAAA
GAAGTAAGAGATAAATTGTTGGAGTTACATGTGAATTATTATGTTTTAGAAGAGGCATGGTGTGTTGTGAGAACTAAGCCTGGTTGCAGT
ATGCTTGAAATCTGGGATGTGGAAGACCCTTCCAATGCAGCTAACCCTCCCTTATGTAGCGTCCTGCTCGAAGACGCCAGGCCTTACTTC
ACCACAGTATTTCAGAATAGTGTGTACAGAGTATTAAAGGTTAACTGAGAAGGATACTACCCATTTTACTATGGCACAATGCCGTGTGTC
AAAAACAATCACCCTTTGGCTTATTCACATTAATAAAAATCACAAGCTTTAATAACAGACACTTAAAAATAAGATAAAAATGGATTGGAA
ATTTTTCTGATTACTAAAAGGTAAATTACTTTTCTGTTCATTGAATGTCAGCCTTATTAAGCTTGTCATATAAGTTATTAAATCATTCAT
GTCATACTGCATAAACAAATGTTCATTTCAGAATTTTAAAGAGAAATGTATATAAAAGAACAATGAATTTTAATAAATCAGGGGTATGTA
AGTCCTTTTTCATCCAACTAGGTGAATTGCTTCAGATTTTCTCTAGTACCAGAGGGTACCTCCTCAAACTCTTTGAACCACTTAAGGCAG
AAGAATGCAAGCTCTGAAATGACATCCTTAAAATGCTGATACTGGTCACAGCCTCTTTACCTCTGTGAGGAAATTGTAACAGTGTGTCTT
TTAAGGTGTTTTTATTTTACCAGCCCTTAAGAAAGATCTCTAATACCTTTTAATACTTTTTTTTAATAATTTCAAGTTGAAGTGTTTTTA
AAAACACTTTGTTTTGTAATGTTTTGAATCTCTTGAGATGTGTTTACCCCACTAGATACATATTTGCCACTGGTTAGTTCTCCATCTAAG
CTCAAGAGGTTATTCATCTCTCTTTAGATTCCAGTGGCTTTTCTTTTAACATCCAGGTAAAACAGAAACTGCTATGGTATACAACCAAGT
TTTGGGGTTAAACATAATCAGAAAAGAAAATCCAGTTAAATTTATGAAGTGAGATTTTCAGATCCTAGATCTTGAATAAAGGAAAGGTCT
TTTCATCTTGATGGCCCCAAAGCTTGTTGGTCATGGTCTTTATTTCTGGCCACTATCTTCTTAAATAATATATTTTTAAGCCCTCATTTA
TTTTTGGTTTTGGGTGAGGAAAGTCATGTTTTCTAAGTCCTCTCCCCTAATAAAACCTACCCAACAATAGTGCTTTGAAAAGTGGTAGTT
ATCTTGAAGATACTCTTGCCAAATGCAAAGATAAACATTCTTTTTGTCTGCTTTATAAATATGAAATATGCCAGATCTATAGTATTTTAA
TGTGCATCTACTTTAAATGAGTCATCTTGGGGTTTTTATAATTCCCTTATGTTCTTGCCCCTCTACACTTGAAATAACAAAATGCCTTAA
TTTTATGGATTAGTTCTCTTATAGTAGACAGGCAGCTATATGCAGCAAAACCAATAAAGTTATTTTTCAACTTTCATAGTTGTAAAATAT
CTTATAACAGAATACAAAACAGCTAAGAAAACATGCCACATTTTATTTTAGCATTTTCAAATAATTTGTTTTTGGTGTAAGCACAGGATA
AAAAAGGAGAGCGTCAAAGAAAAGAGACATAACACCTAACATTCATAAAAATTAACAAAGTATATTTTGGATGATGTTTTTACAGGAAAT
ATTTTAAATAAGTTGGTAGAACTTTTAAAATGGTACTGTATTAGCTAATAAAATATTCAGTACAAATATATGTTTGGATTTATGCATTAA

>97222_97222_2_USP15-DPY19L2_USP15_chr12_62719714_ENST00000312635_DPY19L2_chr12_63977616_ENST00000324472_length(amino acids)=459AA_BP=
MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI
LLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLW
NKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPKKQLLEHSELAFHTLQLLVFTALAILIMRLKMFLTPHMCVMAS
LICSRQLFGWLFRRVRFEKVIFGILTVMSIQGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTSDAVFAGAMPTMASIKLSTLHPIVNHP
HYEDADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLCSVLLEDARPYFTTVFQN

--------------------------------------------------------------
>97222_97222_3_USP15-DPY19L2_USP15_chr12_62719714_ENST00000353364_DPY19L2_chr12_63977616_ENST00000324472_length(transcript)=3056nt_BP=760nt
GTGGGACGCCATTCCCATAATGCTCTGGGGCGTGCCGCCGCCGTCGCTGCCACCTCCCCTACCGCTAGTGGAAGAAGATGGCGGAAGGCG
GAGCGGCGGATCTGGACACCCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTCCGGAAAGGGGACACCTGGTACCTAGTCGATA
GTCGCTGGTTCAAACAGTGGAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAGATGGGAGATCAAAATGTGTATCCTGGACCCA
TTGATAACTCTGGACTTCTCAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATTGATGAATTGGATTACATACTGTTGCCAACTG
AAGGTTGGAATAAACTTGTCAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCACGAAAGGTGGTTGAACAGGGTATGTTTGTAA
AGCACTGCAAAGTAGAAGTATATCTCACAGAATTGAAGCTATGTGAAAATGGAAACATGAATAATGTTGTAACTCGAAGATTTAGCAAAG
CTGACACAATAGATACAATTGAAAAGGAAATAAGAAAAATCTTCAGTATTCCAGATGAAAAGGAGACCAGATTGTGGAACAAATACATGA
GTAACACATTTGAACCACTGAATAAACCAGACAGCACCATTCAGGATGCTGGTTTATACCAAGGACAGGTATTAGTGATAGAACAGAAAA
ATGAAGATGGAACATGGCCAAGGGGTCCTTCTACTCCTAAAAAACAGCTCCTTGAACACAGTGAGCTGGCTTTTCACACATTGCAGTTGT
TAGTGTTTACTGCCCTTGCCATTTTAATTATGAGGCTAAAGATGTTTTTGACACCGCACATGTGTGTTATGGCTTCCTTGATATGCTCTC
GACAGCTCTTTGGCTGGCTTTTTCGCAGAGTTCGTTTTGAGAAGGTTATCTTTGGCATTTTAACAGTGATGTCAATACAAGGTTATGCAA
ACCTCCGTAATCAATGGAGCATAATAGGAGAATTTAATAATTTGCCTCAGGAAGAACTTTTACAGTGGATCAAATACAGTACCACATCAG
ATGCTGTCTTTGCAGGTGCCATGCCTACAATGGCAAGCATCAAGCTGTCTACACTTCATCCCATTGTGAATCATCCACATTACGAAGATG
CAGACTTGAGGGCTCGGACAAAAATAGTTTATTCTACATATAGTCGAAAATCTGCCAAAGAAGTAAGAGATAAATTGTTGGAGTTACATG
TGAATTATTATGTTTTAGAAGAGGCATGGTGTGTTGTGAGAACTAAGCCTGGTTGCAGTATGCTTGAAATCTGGGATGTGGAAGACCCTT
CCAATGCAGCTAACCCTCCCTTATGTAGCGTCCTGCTCGAAGACGCCAGGCCTTACTTCACCACAGTATTTCAGAATAGTGTGTACAGAG
TATTAAAGGTTAACTGAGAAGGATACTACCCATTTTACTATGGCACAATGCCGTGTGTCAAAAACAATCACCCTTTGGCTTATTCACATT
AATAAAAATCACAAGCTTTAATAACAGACACTTAAAAATAAGATAAAAATGGATTGGAAATTTTTCTGATTACTAAAAGGTAAATTACTT
TTCTGTTCATTGAATGTCAGCCTTATTAAGCTTGTCATATAAGTTATTAAATCATTCATGTCATACTGCATAAACAAATGTTCATTTCAG
AATTTTAAAGAGAAATGTATATAAAAGAACAATGAATTTTAATAAATCAGGGGTATGTAAGTCCTTTTTCATCCAACTAGGTGAATTGCT
TCAGATTTTCTCTAGTACCAGAGGGTACCTCCTCAAACTCTTTGAACCACTTAAGGCAGAAGAATGCAAGCTCTGAAATGACATCCTTAA
AATGCTGATACTGGTCACAGCCTCTTTACCTCTGTGAGGAAATTGTAACAGTGTGTCTTTTAAGGTGTTTTTATTTTACCAGCCCTTAAG
AAAGATCTCTAATACCTTTTAATACTTTTTTTTAATAATTTCAAGTTGAAGTGTTTTTAAAAACACTTTGTTTTGTAATGTTTTGAATCT
CTTGAGATGTGTTTACCCCACTAGATACATATTTGCCACTGGTTAGTTCTCCATCTAAGCTCAAGAGGTTATTCATCTCTCTTTAGATTC
CAGTGGCTTTTCTTTTAACATCCAGGTAAAACAGAAACTGCTATGGTATACAACCAAGTTTTGGGGTTAAACATAATCAGAAAAGAAAAT
CCAGTTAAATTTATGAAGTGAGATTTTCAGATCCTAGATCTTGAATAAAGGAAAGGTCTTTTCATCTTGATGGCCCCAAAGCTTGTTGGT
CATGGTCTTTATTTCTGGCCACTATCTTCTTAAATAATATATTTTTAAGCCCTCATTTATTTTTGGTTTTGGGTGAGGAAAGTCATGTTT
TCTAAGTCCTCTCCCCTAATAAAACCTACCCAACAATAGTGCTTTGAAAAGTGGTAGTTATCTTGAAGATACTCTTGCCAAATGCAAAGA
TAAACATTCTTTTTGTCTGCTTTATAAATATGAAATATGCCAGATCTATAGTATTTTAATGTGCATCTACTTTAAATGAGTCATCTTGGG
GTTTTTATAATTCCCTTATGTTCTTGCCCCTCTACACTTGAAATAACAAAATGCCTTAATTTTATGGATTAGTTCTCTTATAGTAGACAG
GCAGCTATATGCAGCAAAACCAATAAAGTTATTTTTCAACTTTCATAGTTGTAAAATATCTTATAACAGAATACAAAACAGCTAAGAAAA
CATGCCACATTTTATTTTAGCATTTTCAAATAATTTGTTTTTGGTGTAAGCACAGGATAAAAAAGGAGAGCGTCAAAGAAAAGAGACATA
ACACCTAACATTCATAAAAATTAACAAAGTATATTTTGGATGATGTTTTTACAGGAAATATTTTAAATAAGTTGGTAGAACTTTTAAAAT

>97222_97222_3_USP15-DPY19L2_USP15_chr12_62719714_ENST00000353364_DPY19L2_chr12_63977616_ENST00000324472_length(amino acids)=459AA_BP=
MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI
LLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLW
NKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPKKQLLEHSELAFHTLQLLVFTALAILIMRLKMFLTPHMCVMAS
LICSRQLFGWLFRRVRFEKVIFGILTVMSIQGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTSDAVFAGAMPTMASIKLSTLHPIVNHP
HYEDADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLCSVLLEDARPYFTTVFQN

--------------------------------------------------------------
>97222_97222_4_USP15-DPY19L2_USP15_chr12_62719714_ENST00000393654_DPY19L2_chr12_63977616_ENST00000324472_length(transcript)=3000nt_BP=704nt
TGGAAGAAGATGGCGGAAGGCGGAGCGGCGGATCTGGACACCCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTCCGGAAAGGG
GACACCTGGTACCTAGTCGATAGTCGCTGGTTCAAACAGTGGAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAGATGGGAGAT
CAAAATGTGTATCCTGGACCCATTGATAACTCTGGACTTCTCAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATTGATGAATTG
GATTACATACTGTTGCCAACTGAAGGTTGGAATAAACTTGTCAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCACGAAAGGTG
GTTGAACAGGGTATGTTTGTAAAGCACTGCAAAGTAGAAGTATATCTCACAGAATTGAAGCTATGTGAAAATGGAAACATGAATAATGTT
GTAACTCGAAGATTTAGCAAAGCTGACACAATAGATACAATTGAAAAGGAAATAAGAAAAATCTTCAGTATTCCAGATGAAAAGGAGACC
AGATTGTGGAACAAATACATGAGTAACACATTTGAACCACTGAATAAACCAGACAGCACCATTCAGGATGCTGGTTTATACCAAGGACAG
GTATTGTTTATTGTATTAGTGATAGAACAGAAAAATGAAGATGGAACATGGCCAAGGGGTCCTTCTACTCCTAAAAAACAGCTCCTTGAA
CACAGTGAGCTGGCTTTTCACACATTGCAGTTGTTAGTGTTTACTGCCCTTGCCATTTTAATTATGAGGCTAAAGATGTTTTTGACACCG
CACATGTGTGTTATGGCTTCCTTGATATGCTCTCGACAGCTCTTTGGCTGGCTTTTTCGCAGAGTTCGTTTTGAGAAGGTTATCTTTGGC
ATTTTAACAGTGATGTCAATACAAGGTTATGCAAACCTCCGTAATCAATGGAGCATAATAGGAGAATTTAATAATTTGCCTCAGGAAGAA
CTTTTACAGTGGATCAAATACAGTACCACATCAGATGCTGTCTTTGCAGGTGCCATGCCTACAATGGCAAGCATCAAGCTGTCTACACTT
CATCCCATTGTGAATCATCCACATTACGAAGATGCAGACTTGAGGGCTCGGACAAAAATAGTTTATTCTACATATAGTCGAAAATCTGCC
AAAGAAGTAAGAGATAAATTGTTGGAGTTACATGTGAATTATTATGTTTTAGAAGAGGCATGGTGTGTTGTGAGAACTAAGCCTGGTTGC
AGTATGCTTGAAATCTGGGATGTGGAAGACCCTTCCAATGCAGCTAACCCTCCCTTATGTAGCGTCCTGCTCGAAGACGCCAGGCCTTAC
TTCACCACAGTATTTCAGAATAGTGTGTACAGAGTATTAAAGGTTAACTGAGAAGGATACTACCCATTTTACTATGGCACAATGCCGTGT
GTCAAAAACAATCACCCTTTGGCTTATTCACATTAATAAAAATCACAAGCTTTAATAACAGACACTTAAAAATAAGATAAAAATGGATTG
GAAATTTTTCTGATTACTAAAAGGTAAATTACTTTTCTGTTCATTGAATGTCAGCCTTATTAAGCTTGTCATATAAGTTATTAAATCATT
CATGTCATACTGCATAAACAAATGTTCATTTCAGAATTTTAAAGAGAAATGTATATAAAAGAACAATGAATTTTAATAAATCAGGGGTAT
GTAAGTCCTTTTTCATCCAACTAGGTGAATTGCTTCAGATTTTCTCTAGTACCAGAGGGTACCTCCTCAAACTCTTTGAACCACTTAAGG
CAGAAGAATGCAAGCTCTGAAATGACATCCTTAAAATGCTGATACTGGTCACAGCCTCTTTACCTCTGTGAGGAAATTGTAACAGTGTGT
CTTTTAAGGTGTTTTTATTTTACCAGCCCTTAAGAAAGATCTCTAATACCTTTTAATACTTTTTTTTAATAATTTCAAGTTGAAGTGTTT
TTAAAAACACTTTGTTTTGTAATGTTTTGAATCTCTTGAGATGTGTTTACCCCACTAGATACATATTTGCCACTGGTTAGTTCTCCATCT
AAGCTCAAGAGGTTATTCATCTCTCTTTAGATTCCAGTGGCTTTTCTTTTAACATCCAGGTAAAACAGAAACTGCTATGGTATACAACCA
AGTTTTGGGGTTAAACATAATCAGAAAAGAAAATCCAGTTAAATTTATGAAGTGAGATTTTCAGATCCTAGATCTTGAATAAAGGAAAGG
TCTTTTCATCTTGATGGCCCCAAAGCTTGTTGGTCATGGTCTTTATTTCTGGCCACTATCTTCTTAAATAATATATTTTTAAGCCCTCAT
TTATTTTTGGTTTTGGGTGAGGAAAGTCATGTTTTCTAAGTCCTCTCCCCTAATAAAACCTACCCAACAATAGTGCTTTGAAAAGTGGTA
GTTATCTTGAAGATACTCTTGCCAAATGCAAAGATAAACATTCTTTTTGTCTGCTTTATAAATATGAAATATGCCAGATCTATAGTATTT
TAATGTGCATCTACTTTAAATGAGTCATCTTGGGGTTTTTATAATTCCCTTATGTTCTTGCCCCTCTACACTTGAAATAACAAAATGCCT
TAATTTTATGGATTAGTTCTCTTATAGTAGACAGGCAGCTATATGCAGCAAAACCAATAAAGTTATTTTTCAACTTTCATAGTTGTAAAA
TATCTTATAACAGAATACAAAACAGCTAAGAAAACATGCCACATTTTATTTTAGCATTTTCAAATAATTTGTTTTTGGTGTAAGCACAGG
ATAAAAAAGGAGAGCGTCAAAGAAAAGAGACATAACACCTAACATTCATAAAAATTAACAAAGTATATTTTGGATGATGTTTTTACAGGA
AATATTTTAAATAAGTTGGTAGAACTTTTAAAATGGTACTGTATTAGCTAATAAAATATTCAGTACAAATATATGTTTGGATTTATGCAT

>97222_97222_4_USP15-DPY19L2_USP15_chr12_62719714_ENST00000393654_DPY19L2_chr12_63977616_ENST00000324472_length(amino acids)=463AA_BP=
MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI
LLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLW
NKYMSNTFEPLNKPDSTIQDAGLYQGQVLFIVLVIEQKNEDGTWPRGPSTPKKQLLEHSELAFHTLQLLVFTALAILIMRLKMFLTPHMC
VMASLICSRQLFGWLFRRVRFEKVIFGILTVMSIQGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTSDAVFAGAMPTMASIKLSTLHPI
VNHPHYEDADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLCSVLLEDARPYFTT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for USP15-DPY19L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for USP15-DPY19L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for USP15-DPY19L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource