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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP15-PKP4 (FusionGDB2 ID:97227)

Fusion Gene Summary for USP15-PKP4

check button Fusion gene summary
Fusion gene informationFusion gene name: USP15-PKP4
Fusion gene ID: 97227
HgeneTgene
Gene symbol

USP15

PKP4

Gene ID

9958

8502

Gene nameubiquitin specific peptidase 15plakophilin 4
SynonymsUNPH-2|UNPH4p0071
Cytomap

12q14.1

2q24.1

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 15deubiquitinating enzyme 15ubiquitin thioesterase 15ubiquitin thiolesterase 15ubiquitin-specific-processing protease 15plakophilin-4catenin 4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000280377, ENST00000353364, 
ENST00000393654, ENST00000312635, 
ENST00000550632, 		ENST00000495123, 
ENST00000389757, ENST00000389759, 
Fusion gene scores* DoF score23 X 14 X 12=386415 X 19 X 6=1710
# samples 2622
** MAII scorelog2(26/3864*10)=-3.89351156580732
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/1710*10)=-2.9584208962486
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP15 [Title/Abstract] AND PKP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP15(62783768)-PKP4(159497139), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP15

GO:0007179

transforming growth factor beta receptor signaling pathway

21947082

HgeneUSP15

GO:0016579

protein deubiquitination

16005295|22344298|27368102

HgeneUSP15

GO:0030509

BMP signaling pathway

21947082

HgeneUSP15

GO:0035520

monoubiquitinated protein deubiquitination

21947082|24399297

HgeneUSP15

GO:0035616

histone H2B conserved C-terminal lysine deubiquitination

24526689

HgeneUSP15

GO:1900246

positive regulation of RIG-I signaling pathway

24399297

TgenePKP4

GO:0043547

positive regulation of GTPase activity

17115030


check buttonFusion gene breakpoints across USP15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PKP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0AM-01AUSP15chr12

62783768

-PKP4chr2

159497139

+
ChimerDB4BRCATCGA-AN-A0AM-01AUSP15chr12

62783768

+PKP4chr2

159497139

+


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Fusion Gene ORF analysis for USP15-PKP4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000280377ENST00000495123USP15chr12

62783768

+PKP4chr2

159497139

+
5CDS-intronENST00000353364ENST00000495123USP15chr12

62783768

+PKP4chr2

159497139

+
5CDS-intronENST00000393654ENST00000495123USP15chr12

62783768

+PKP4chr2

159497139

+
In-frameENST00000280377ENST00000389757USP15chr12

62783768

+PKP4chr2

159497139

+
In-frameENST00000280377ENST00000389759USP15chr12

62783768

+PKP4chr2

159497139

+
In-frameENST00000353364ENST00000389757USP15chr12

62783768

+PKP4chr2

159497139

+
In-frameENST00000353364ENST00000389759USP15chr12

62783768

+PKP4chr2

159497139

+
In-frameENST00000393654ENST00000389757USP15chr12

62783768

+PKP4chr2

159497139

+
In-frameENST00000393654ENST00000389759USP15chr12

62783768

+PKP4chr2

159497139

+
intron-3CDSENST00000312635ENST00000389757USP15chr12

62783768

+PKP4chr2

159497139

+
intron-3CDSENST00000312635ENST00000389759USP15chr12

62783768

+PKP4chr2

159497139

+
intron-3CDSENST00000550632ENST00000389757USP15chr12

62783768

+PKP4chr2

159497139

+
intron-3CDSENST00000550632ENST00000389759USP15chr12

62783768

+PKP4chr2

159497139

+
intron-intronENST00000312635ENST00000495123USP15chr12

62783768

+PKP4chr2

159497139

+
intron-intronENST00000550632ENST00000495123USP15chr12

62783768

+PKP4chr2

159497139

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000353364USP15chr1262783768+ENST00000389757PKP4chr2159497139+592418347737211214
ENST00000353364USP15chr1262783768+ENST00000389759PKP4chr2159497139+460318347738501257
ENST00000280377USP15chr1262783768+ENST00000389757PKP4chr2159497139+599219025837891243
ENST00000280377USP15chr1262783768+ENST00000389759PKP4chr2159497139+467119025839181286
ENST00000393654USP15chr1262783768+ENST00000389757PKP4chr2159497139+58681778936651218
ENST00000393654USP15chr1262783768+ENST00000389759PKP4chr2159497139+45471778937941261

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000353364ENST00000389757USP15chr1262783768+PKP4chr2159497139+0.0001940950.99980587
ENST00000353364ENST00000389759USP15chr1262783768+PKP4chr2159497139+0.00023470.99976534
ENST00000280377ENST00000389757USP15chr1262783768+PKP4chr2159497139+0.0002769570.999723
ENST00000280377ENST00000389759USP15chr1262783768+PKP4chr2159497139+0.0002457580.99975425
ENST00000393654ENST00000389757USP15chr1262783768+PKP4chr2159497139+0.0001770290.99982303
ENST00000393654ENST00000389759USP15chr1262783768+PKP4chr2159497139+0.0002128370.99978715

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Fusion Genomic Features for USP15-PKP4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
USP15chr1262783768+PKP4chr2159497138+0.0007443150.9992557
USP15chr1262783768+PKP4chr2159497138+0.0007443150.9992557

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for USP15-PKP4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:62783768/chr2:159497139)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP15chr12:62783768chr2:159497139ENST00000280377+14227_118614982.0DomainDUSP
HgeneUSP15chr12:62783768chr2:159497139ENST00000353364+13217_118585953.0DomainDUSP
TgenePKP4chr12:62783768chr2:159497139ENST00000389757821788_7945201150.0Compositional biasNote=Poly-Lys
TgenePKP4chr12:62783768chr2:159497139ENST00000389759822788_7945201193.0Compositional biasNote=Poly-Lys
TgenePKP4chr12:62783768chr2:159497139ENST00000389757821518_5575201150.0RepeatNote=ARM 2
TgenePKP4chr12:62783768chr2:159497139ENST00000389757821560_5995201150.0RepeatNote=ARM 3
TgenePKP4chr12:62783768chr2:159497139ENST00000389757821604_6445201150.0RepeatNote=ARM 4
TgenePKP4chr12:62783768chr2:159497139ENST00000389757821660_7025201150.0RepeatNote=ARM 5
TgenePKP4chr12:62783768chr2:159497139ENST00000389757821706_7515201150.0RepeatNote=ARM 6
TgenePKP4chr12:62783768chr2:159497139ENST00000389757821815_8555201150.0RepeatNote=ARM 7
TgenePKP4chr12:62783768chr2:159497139ENST00000389757821862_9015201150.0RepeatNote=ARM 8
TgenePKP4chr12:62783768chr2:159497139ENST00000389757821950_9935201150.0RepeatNote=ARM 9
TgenePKP4chr12:62783768chr2:159497139ENST00000389759822518_5575201193.0RepeatNote=ARM 2
TgenePKP4chr12:62783768chr2:159497139ENST00000389759822560_5995201193.0RepeatNote=ARM 3
TgenePKP4chr12:62783768chr2:159497139ENST00000389759822604_6445201193.0RepeatNote=ARM 4
TgenePKP4chr12:62783768chr2:159497139ENST00000389759822660_7025201193.0RepeatNote=ARM 5
TgenePKP4chr12:62783768chr2:159497139ENST00000389759822706_7515201193.0RepeatNote=ARM 6
TgenePKP4chr12:62783768chr2:159497139ENST00000389759822815_8555201193.0RepeatNote=ARM 7
TgenePKP4chr12:62783768chr2:159497139ENST00000389759822862_9015201193.0RepeatNote=ARM 8
TgenePKP4chr12:62783768chr2:159497139ENST00000389759822950_9935201193.0RepeatNote=ARM 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP15chr12:62783768chr2:159497139ENST00000280377+1422289_933614982.0DomainUSP
HgeneUSP15chr12:62783768chr2:159497139ENST00000312635+17289_9330236.0DomainUSP
HgeneUSP15chr12:62783768chr2:159497139ENST00000312635+177_1180236.0DomainDUSP
HgeneUSP15chr12:62783768chr2:159497139ENST00000353364+1321289_933585953.0DomainUSP
TgenePKP4chr12:62783768chr2:159497139ENST0000038975782136_705201150.0Coiled coilOntology_term=ECO:0000255
TgenePKP4chr12:62783768chr2:159497139ENST0000038975982236_705201193.0Coiled coilOntology_term=ECO:0000255
TgenePKP4chr12:62783768chr2:159497139ENST00000389757821415_4555201150.0RepeatNote=ARM 1
TgenePKP4chr12:62783768chr2:159497139ENST00000389759822415_4555201193.0RepeatNote=ARM 1


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Fusion Gene Sequence for USP15-PKP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97227_97227_1_USP15-PKP4_USP15_chr12_62783768_ENST00000280377_PKP4_chr2_159497139_ENST00000389757_length(transcript)=5992nt_BP=1902nt
ATGCTCTGGGGCGTGCCGCCGCCGTCGCTGCCACCTCCCCTACCGCTAGTGGAAGAAGATGGCGGAAGGCGGAGCGGCGGATCTGGACAC
CCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTCCGGAAAGGGGACACCTGGTACCTAGTCGATAGTCGCTGGTTCAAACAGTG
GAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAGATGGGAGATCAAAATGTGTATCCTGGACCCATTGATAACTCTGGACTTCT
CAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATTGATGAATTGGATTACATACTGTTGCCAACTGAAGGTTGGAATAAACTTGT
CAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCACGAAAGGTGGTTGAACAGGGTATGTTTGTAAAGCACTGCAAAGTAGAAGT
ATATCTCACAGAATTGAAGCTATGTGAAAATGGAAACATGAATAATGTTGTAACTCGAAGATTTAGCAAAGCTGACACAATAGATACAAT
TGAAAAGGAAATAAGAAAAATCTTCAGTATTCCAGATGAAAAGGAGACCAGATTGTGGAACAAATACATGAGTAACACATTTGAACCACT
GAATAAACCAGACAGCACCATTCAGGATGCTGGTTTATACCAAGGACAGGTATTAGTGATAGAACAGAAAAATGAAGATGGAACATGGCC
AAGGGGTCCTTCTACTCCTAAGTCCCCAGGTGCATCCAATTTTTCAACTTTACCAAAGATCTCTCCTTCATCTCTATCAAATAATTATAA
CAACATGAACAACAGAAATGTGAAAAACTCAAATTACTGTCTTCCATCATATACCGCTTATAAGAACTATGATTATTCGGAACCTGGAAG
AAACAATGAACAGCCAGGCCTCTGTGGCCTAAGTAACTTGGGAAATACGTGTTTCATGAACTCAGCTATTCAGTGTTTGAGCAACACACC
TCCACTTACTGAGTATTTCCTCAATGATAAGTATCAAGAAGAACTGAATTTTGACAATCCCTTAGGAATGAGAGGTGAAATAGCTAAATC
TTATGCCGAACTGATCAAGCAAATGTGGTCTGGAAAGTTTAGCTACGTCACCCCAAGAGCCTTTAAGACACAGGTAGGACGTTTTGCACC
TCAGTTCTCTGGATATCAGCAGCAAGACTGTCAAGAACTGTTAGCTTTCCTATTAGATGGATTACATGAGGATTTGAATAGAATTAGGAA
AAAACCATATATACAATTAAAAGATGCAGATGGAAGGCCAGATAAGGTGGTTGCCGAAGAAGCCTGGGAAAACCATTTAAAACGAAATGA
TTCTATCATAGTAGATATATTTCATGGCCTTTTCAAATCAACTTTAGTTTGTCCTGAGTGTGCTAAGATTTCAGTAACATTTGATCCTTT
TTGTTACTTGACACTTCCATTGCCCATGAAAAAAGAACGCACCTTGGAAGTTTACTTAGTTAGAATGGATCCACTTACCAAACCTATGCA
GTACAAAGTGGTTGTCCCCAAAATTGGAAACATATTAGATCTTTGTACAGCATTGTCTGCTTTGTCAGGAATACCTGCAGATAAGATGAT
AGTTACTGATATATACAATCATAGATTTCACAGAATATTCGCTATGGATGAAAACCTTAGTAGTATTATGGAACGGGATGATATTTATGT
GTTTGAAATTAACATCAATAGGACAGAAGATACAGAGCACGTGATTATTCCTGTTTGCCTAAGAGAAAAATTCAGACACTCGAGTTATAC
CCACCATACTGGTTCTTCACTTTTTGGTCAGCCCTTTCTTATGGCTGTACCACGAAACAATACTGAAGACAAACTTTATAATCTCCTGCT
CTTGAGAATGTGGGAGTTTGCCTGGCGTGATCCTGAGTTGCCTGAGGTCATTCACATGCTTCAGCACCAGTTCCCATCTGTTCAGGCAAA
TGCAGCGGCCTACCTGCAGCACCTGTGCTTTGGTGACAACAAAGTGAAGATGGAGGTGTGTAGGTTAGGGGGAATCAAGCATCTGGTTGA
CCTTCTGGACCACAGAGTTTTGGAAGTTCAGAAGAATGCTTGTGGTGCCCTTCGAAACCTCGTTTTTGGCAAGTCTACAGATGAAAATAA
AATAGCAATGAAGAATGTTGGTGGGATACCTGCCTTGTTGCGACTGTTGAGAAAATCTATTGATGCAGAAGTAAGGGAGCTTGTTACAGG
AGTTCTTTGGAATTTATCCTCATGTGATGCTGTAAAAATGACAATCATTCGAGATGCTCTCTCAACCTTAACAAACACTGTGATTGTTCC
ACATTCTGGATGGAATAACTCTTCTTTTGATGATGATCATAAAATTAAATTTCAGACTTCACTAGTTCTGCGTAACACGACAGGTTGCCT
AAGGAACCTCAGCTCCGCGGGGGAAGAAGCTCGGAAGCAAATGCGGTCCTGCGAGGGGCTGGTAGACTCACTGTTGTATGTGATCCACAC
GTGTGTGAACACATCCGATTACGACAGCAAGACGGTGGAGAACTGCGTGTGCACCCTGAGGAACCTGTCCTATCGGCTGGAGCTGGAGGT
GCCCCAGGCCCGGTTACTGGGACTGAACGAATTGGATGACTTACTAGGAAAAGAGTCTCCCAGCAAAGACTCTGAGCCAAGTTGCTGGGG
GAAGAAGAAGAAAAAGAAAAAGAGGACTCCGCAAGAAGATCAATGGGATGGAGTTGGTCCTATCCCAGGACTGTCGAAGTCCCCCAAAGG
GGTTGAGATGCTGTGGCACCCATCGGTGGTAAAACCATATCTGACTCTTCTAGCAGAAAGTTCCAACCCAGCCACCTTGGAAGGCTCTGC
AGGGTCTCTCCAGAACCTCTCTGCTGGCAACTGGAAGTTTGCAGCATATATCCGGGCGGCCGTCCGAAAAGAAAAGGGGCTCCCCATCCT
TGTGGAGCTTCTGAGAATGGATAACGATAGAGTTGTTTCTTCCGTGGCAACAGCCTTGAGGAATATGGCACTAGATGTTCGCAACAAGGA
GCTCATAGGCAAATACGCCATGCGAGACCTGGTCAACCGGCTCCCCGGCGGCAATGGCCCCAGTGTCTTGTCTGATGAGACCATGGCAGC
CATCTGCTGTGCTCTGCACGAGGTCACCAGCAAAAACATGGAGAACGCAAAAGCCCTGGCCGACTCAGGAGGCATAGAGAAGCTGGTGAA
CATAACCAAAGGCAGGGGCGACAGATCATCTCTGAAAGTGGTGAAGGCAGCAGCCCAGGTCTTGAATACATTATGGCAATATCGGGACCT
CCGGAGCATTTATAAAAAGGATGGGTGGAATCAGAACCATTTTATTACACCTGTGTCGACATTGGAGCGAGACCGATTCAAATCACATCC
TTCCTTGTCTACCACCAACCAACAGATGTCACCCATCATTCAGTCAGGCTCCAGCAAACCTTCACCAATTTACATCAGTTCCTATTCCTC
ACCAGCAAGAGAACAAAATAGACGGCTACAGCATCAACAGCTGTATTATAGTCAAGATGACTCCAACAGAAAGAACTTTGATGCATACAG
ATTGTATTTGCAGTCTCCTCATAGCTATGAAGATCCTTATTTTGATGACCGAGTTCACTTTCCAGCTTCTACTGATTACTCAACACAGTA
TGGACTGAAATCGACCACAAATTATGTAGACTTTTATTCCACTAAACGACCTTCTTATAGAGCAGAACAGTACCCAGGGTCCCCAGACTC
ATGGGTGTAGCATCAAGATGCCCAACAGAGGAACTCTTTCTTTCTAACCTTGTTCAGATTGAGGTGAAAAGTCCATCTTGCTGATTTGAT
GATTGAAATGTGAAAGTGAAGTGGAAGGAATGAATGAAGTGTGTTTTTTTTTTCTTTTTTGAGGAATTATCAGGGAAGTGAGGAAATGTT
TGGGAGAGGACTTTCTAAGCTCTATTTAGGTGTTAGATCTAATTACTTATAGATTCTGTAGTCTGGTGAAGGTGTGGGTGACGTGATGAG
AGGTTTGAGAAATGGGTGAAATGAAATGGGGGATATGTAGGTCAAATCAAATTAAAGATGATTTTTTTAATGTGAATAAAGTTATGTTCT
GATAGTTTGTACAGAAAAAATAAAATGGATGCCCATGTTTTATTGCTATTACTAAATGTCAAGATTGTATGCTATTATGTCTTGTAAATT
TCTTTTGTTGGTGTAAATATGGAAATGCCACATTGGTTAAGTGCCATCATTTGTAATGCAATGTGTCACTTGAAAAGAGATTTGAAGAAA
CTGACAACTTCAAAAACAAATGAGAAGCCCAAGGAACTGTGAGCAATTAAAAGCAAACCGCGACACCCTTTGTCTCCACCACACATAGTG
TACTTTGGAAGCACAACGTCCAGGCTGGTACCGCAGCGCCATGCCCATTCCTCGCCTCATTCATAGGACACTTCACTGCCATTTTCTATT
CACATAAAAGAAAAATAAATGTGGAAATTTCATCCTTGGAAATGTGTTCTCTATTCTTTTTAAATTTTCTGTATGTATATGGAAAAGCAG
ATTTAATAAACACAAATCTAACTGCATGTTGGAAACAGCTTAAATATATCCAACTATTTTGGACTTTTCCTAGTTTTATATATACTTTGT
GAGATGGACCACACCAAAGAATTAAGCTATGAACTTTCCTTCTCTGACAATCTAGGTATTTTTATTTCTTGGAATCTATTTCAAATCTAG
TACCCTTCACAGTTTTATCATGTTTTTCTATATGGCAGCCCGGCCATAACTAAATTGATATAACTAAATTGATACCTTTTTTAGGCATCA
TTTTTAAGAACTCAGTAACTTCATAAGAACAGTGGTTGGGCATTTATTTGGTTGGCACCAATATAATAAAACAAATTCTAAATTATGATC
TTGTTGAGTAATTCCTGGATTAGGAATGGGGTAGGGGAAAGAAGCCCCACAGTAGGGTAGGCAGAGGTCCCCATAGCACCACACAGCATT
ACTTGGGAGCTTTTCTCCATCTGTGGAGGCAATGAGGGACACCAGGCCCAAAGTCTGAGGCCTTCTCAGGTCTTGCAGTTTCCACCCTTC
AGTCCTAGCTCCTGGATCTTTGTTGGTGTAAATATGGAAATGCCACATTGGTTAAGTGCCATCATGGAAAACTAGGAACTAGTTTACCTG
TAGCTGTACTAGGAAAACTAGGAACTAACGCCCATGGCAAGTCAAACCCAGAAGTGTTGTCTTAGCTCAATATACCCTGCAAGTGTAATA
CAAATCGCAGATTAAAACATTTGTACTTATATTTGTGAGTATATGGAAAGACACCCAAGAGAAAACTGCGTTTTCTTGCCGAATGGACAG
CAGCCCAAGATGAGCATCCAAAGTGAAATGGAAATACCAGTGCGAGCATGAAAGTTCCTAAGATCTGCAAGCCGGGAGCCCTTCTGGGGT
GCCTTCTGAAGAACACTCGAGCCAGCTTGCGGAGTCGACTGCCCAGCTACTGAGCCCTGGCTGCCTCATACCTGGCGGAGCTCAGCAGAC
AGCCCTTGTTAGATGGCAGAGGTCGCCAGATGTTCCTGAGGAACTGGCATCAGGACTTCTGGGACGTAACCACTTCAGTTTCCAATCACT
GACTTCCCTGAACCTGGTATCTTCAGATCTGGGTTGAAGCTGAAGGCTCAGTTGGGGAATCAGGAAAACAAGGGAATCGGAGCCAGCCCA
AGCCAACTGACAATAACTTTCTTTTAGTGACTGCATTAGTTTGGGGTAATGCTGTAACAGGCAGCATTTCAAAAACGGATCCAAATTTGG
GTTGAAAATAACTCACCTGGGTCTCCAATCAGACCTAACAGAGCCAGAAAGAGGCCTGTACACGGGGACTGGGCAGAAGATCTAATGCCG

>97227_97227_1_USP15-PKP4_USP15_chr12_62783768_ENST00000280377_PKP4_chr2_159497139_ENST00000389757_length(amino acids)=1243AA_BP=615
MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI
LLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLW
NKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPKSPGASNFSTLPKISPSSLSNNYNNMNNRNVKNSNYCLPSYTA
YKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPR
AFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPE
CAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENL
SSIMERDDIYVFEININRTEDTEHVIIPVCLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMWEFAWRDPELPEVIHM
LQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKS
IDAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEG
LVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVG
PIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATAL
RNMALDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQ
VLNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSHPSLSTTNQQMSPIIQSGSSKPSPIYISSYSSPAREQNRRLQHQQLYYSQD

--------------------------------------------------------------
>97227_97227_2_USP15-PKP4_USP15_chr12_62783768_ENST00000280377_PKP4_chr2_159497139_ENST00000389759_length(transcript)=4671nt_BP=1902nt
ATGCTCTGGGGCGTGCCGCCGCCGTCGCTGCCACCTCCCCTACCGCTAGTGGAAGAAGATGGCGGAAGGCGGAGCGGCGGATCTGGACAC
CCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTCCGGAAAGGGGACACCTGGTACCTAGTCGATAGTCGCTGGTTCAAACAGTG
GAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAGATGGGAGATCAAAATGTGTATCCTGGACCCATTGATAACTCTGGACTTCT
CAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATTGATGAATTGGATTACATACTGTTGCCAACTGAAGGTTGGAATAAACTTGT
CAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCACGAAAGGTGGTTGAACAGGGTATGTTTGTAAAGCACTGCAAAGTAGAAGT
ATATCTCACAGAATTGAAGCTATGTGAAAATGGAAACATGAATAATGTTGTAACTCGAAGATTTAGCAAAGCTGACACAATAGATACAAT
TGAAAAGGAAATAAGAAAAATCTTCAGTATTCCAGATGAAAAGGAGACCAGATTGTGGAACAAATACATGAGTAACACATTTGAACCACT
GAATAAACCAGACAGCACCATTCAGGATGCTGGTTTATACCAAGGACAGGTATTAGTGATAGAACAGAAAAATGAAGATGGAACATGGCC
AAGGGGTCCTTCTACTCCTAAGTCCCCAGGTGCATCCAATTTTTCAACTTTACCAAAGATCTCTCCTTCATCTCTATCAAATAATTATAA
CAACATGAACAACAGAAATGTGAAAAACTCAAATTACTGTCTTCCATCATATACCGCTTATAAGAACTATGATTATTCGGAACCTGGAAG
AAACAATGAACAGCCAGGCCTCTGTGGCCTAAGTAACTTGGGAAATACGTGTTTCATGAACTCAGCTATTCAGTGTTTGAGCAACACACC
TCCACTTACTGAGTATTTCCTCAATGATAAGTATCAAGAAGAACTGAATTTTGACAATCCCTTAGGAATGAGAGGTGAAATAGCTAAATC
TTATGCCGAACTGATCAAGCAAATGTGGTCTGGAAAGTTTAGCTACGTCACCCCAAGAGCCTTTAAGACACAGGTAGGACGTTTTGCACC
TCAGTTCTCTGGATATCAGCAGCAAGACTGTCAAGAACTGTTAGCTTTCCTATTAGATGGATTACATGAGGATTTGAATAGAATTAGGAA
AAAACCATATATACAATTAAAAGATGCAGATGGAAGGCCAGATAAGGTGGTTGCCGAAGAAGCCTGGGAAAACCATTTAAAACGAAATGA
TTCTATCATAGTAGATATATTTCATGGCCTTTTCAAATCAACTTTAGTTTGTCCTGAGTGTGCTAAGATTTCAGTAACATTTGATCCTTT
TTGTTACTTGACACTTCCATTGCCCATGAAAAAAGAACGCACCTTGGAAGTTTACTTAGTTAGAATGGATCCACTTACCAAACCTATGCA
GTACAAAGTGGTTGTCCCCAAAATTGGAAACATATTAGATCTTTGTACAGCATTGTCTGCTTTGTCAGGAATACCTGCAGATAAGATGAT
AGTTACTGATATATACAATCATAGATTTCACAGAATATTCGCTATGGATGAAAACCTTAGTAGTATTATGGAACGGGATGATATTTATGT
GTTTGAAATTAACATCAATAGGACAGAAGATACAGAGCACGTGATTATTCCTGTTTGCCTAAGAGAAAAATTCAGACACTCGAGTTATAC
CCACCATACTGGTTCTTCACTTTTTGGTCAGCCCTTTCTTATGGCTGTACCACGAAACAATACTGAAGACAAACTTTATAATCTCCTGCT
CTTGAGAATGTGGGAGTTTGCCTGGCGTGATCCTGAGTTGCCTGAGGTCATTCACATGCTTCAGCACCAGTTCCCATCTGTTCAGGCAAA
TGCAGCGGCCTACCTGCAGCACCTGTGCTTTGGTGACAACAAAGTGAAGATGGAGGTGTGTAGGTTAGGGGGAATCAAGCATCTGGTTGA
CCTTCTGGACCACAGAGTTTTGGAAGTTCAGAAGAATGCTTGTGGTGCCCTTCGAAACCTCGTTTTTGGCAAGTCTACAGATGAAAATAA
AATAGCAATGAAGAATGTTGGTGGGATACCTGCCTTGTTGCGACTGTTGAGAAAATCTATTGATGCAGAAGTAAGGGAGCTTGTTACAGG
AGTTCTTTGGAATTTATCCTCATGTGATGCTGTAAAAATGACAATCATTCGAGATGCTCTCTCAACCTTAACAAACACTGTGATTGTTCC
ACATTCTGGATGGAATAACTCTTCTTTTGATGATGATCATAAAATTAAATTTCAGACTTCACTAGTTCTGCGTAACACGACAGGTTGCCT
AAGGAACCTCAGCTCCGCGGGGGAAGAAGCTCGGAAGCAAATGCGGTCCTGCGAGGGGCTGGTAGACTCACTGTTGTATGTGATCCACAC
GTGTGTGAACACATCCGATTACGACAGCAAGACGGTGGAGAACTGCGTGTGCACCCTGAGGAACCTGTCCTATCGGCTGGAGCTGGAGGT
GCCCCAGGCCCGGTTACTGGGACTGAACGAATTGGATGACTTACTAGGAAAAGAGTCTCCCAGCAAAGACTCTGAGCCAAGTTGCTGGGG
GAAGAAGAAGAAAAAGAAAAAGAGGACTCCGCAAGAAGATCAATGGGATGGAGTTGGTCCTATCCCAGGACTGTCGAAGTCCCCCAAAGG
GGTTGAGATGCTGTGGCACCCATCGGTGGTAAAACCATATCTGACTCTTCTAGCAGAAAGTTCCAACCCAGCCACCTTGGAAGGCTCTGC
AGGGTCTCTCCAGAACCTCTCTGCTGGCAACTGGAAGTTTGCAGCATATATCCGGGCGGCCGTCCGAAAAGAAAAGGGGCTCCCCATCCT
TGTGGAGCTTCTGAGAATGGATAACGATAGAGTTGTTTCTTCCGTGGCAACAGCCTTGAGGAATATGGCACTAGATGTTCGCAACAAGGA
GCTCATAGGCAAATACGCCATGCGAGACCTGGTCAACCGGCTCCCCGGCGGCAATGGCCCCAGTGTCTTGTCTGATGAGACCATGGCAGC
CATCTGCTGTGCTCTGCACGAGGTCACCAGCAAAAACATGGAGAACGCAAAAGCCCTGGCCGACTCAGGAGGCATAGAGAAGCTGGTGAA
CATAACCAAAGGCAGGGGCGACAGATCATCTCTGAAAGTGGTGAAGGCAGCAGCCCAGGTCTTGAATACATTATGGCAATATCGGGACCT
CCGGAGCATTTATAAAAAGGATGGGTGGAATCAGAACCATTTTATTACACCTGTGTCGACATTGGAGCGAGACCGATTCAAATCACATCC
TTCCTTGTCTACCACCAACCAACAGATGTCACCCATCATTCAGTCAGTCGGCAGCACCTCTTCCTCACCAGCACTGTTAGGAATCAGAGA
CCCTCGCTCTGAATACGATAGGACCCAGCCACCTATGCAGTATTACAATAGCCAAGGGGATGCCACACATAAAGGCCTGTACCCTGGCTC
CAGCAAACCTTCACCAATTTACATCAGTTCCTATTCCTCACCAGCAAGAGAACAAAATAGACGGCTACAGCATCAACAGCTGTATTATAG
TCAAGATGACTCCAACAGAAAGAACTTTGATGCATACAGATTGTATTTGCAGTCTCCTCATAGCTATGAAGATCCTTATTTTGATGACCG
AGTTCACTTTCCAGCTTCTACTGATTACTCAACACAGTATGGACTGAAATCGACCACAAATTATGTAGACTTTTATTCCACTAAACGACC
TTCTTATAGAGCAGAACAGTACCCAGGGTCCCCAGACTCATGGGTGTAGCATCAAGATGCCCAACAGAGGAACTCTTTCTTTCTAACCTT
GTTCAGATTGAGGTGAAAAGTCCATCTTGCTGATTTGATGATTGAAATGTGAAAGTGAAGTGGAAGGAATGAATGAAGTGTGTTTTTTTT
TTCTTTTTTGAGGAATTATCAGGGAAGTGAGGAAATGTTTGGGAGAGGACTTTCTAAGCTCTATTTAGGTGTTAGATCTAATTACTTATA
GATTCTGTAGTCTGGTGAAGGTGTGGGTGACGTGATGAGAGGTTTGAGAAATGGGTGAAATGAAATGGGGGATATGTAGGTCAAATCAAA
TTAAAGATGATTTTTTTAATGTGAATAAAGTTATGTTCTGATAGTTTGTACAGAAAAAATAAAATGGATGCCCATGTTTTATTGCTATTA
CTAAATGTCAAGATTGTATGCTATTATGTCTTGTAAATTTCTTTTGTTGGTGTAAATATGGAAATGCCACATTGGTTAAGTGCCATCATT
TGTAATGCAATGTGTCACTTGAAAAGAGATTTGAAGAAACTGACAACTTCAAAAACAAATGAGAAGCCCAAGGAACTGTGAGCAATTAAA
AGCAAACCGCGACACCCTTTGTCTCCACCACACATAGTGTACTTTGGAAGCACAACGTCCAGGCTGGTACCGCAGCGCCATGCCCATTCC

>97227_97227_2_USP15-PKP4_USP15_chr12_62783768_ENST00000280377_PKP4_chr2_159497139_ENST00000389759_length(amino acids)=1286AA_BP=615
MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI
LLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLW
NKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPKSPGASNFSTLPKISPSSLSNNYNNMNNRNVKNSNYCLPSYTA
YKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPR
AFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPE
CAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENL
SSIMERDDIYVFEININRTEDTEHVIIPVCLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMWEFAWRDPELPEVIHM
LQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKS
IDAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEG
LVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVG
PIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATAL
RNMALDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQ
VLNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSHPSLSTTNQQMSPIIQSVGSTSSSPALLGIRDPRSEYDRTQPPMQYYNSQG
DATHKGLYPGSSKPSPIYISSYSSPAREQNRRLQHQQLYYSQDDSNRKNFDAYRLYLQSPHSYEDPYFDDRVHFPASTDYSTQYGLKSTT

--------------------------------------------------------------
>97227_97227_3_USP15-PKP4_USP15_chr12_62783768_ENST00000353364_PKP4_chr2_159497139_ENST00000389757_length(transcript)=5924nt_BP=1834nt
GTGGGACGCCATTCCCATAATGCTCTGGGGCGTGCCGCCGCCGTCGCTGCCACCTCCCCTACCGCTAGTGGAAGAAGATGGCGGAAGGCG
GAGCGGCGGATCTGGACACCCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTCCGGAAAGGGGACACCTGGTACCTAGTCGATA
GTCGCTGGTTCAAACAGTGGAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAGATGGGAGATCAAAATGTGTATCCTGGACCCA
TTGATAACTCTGGACTTCTCAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATTGATGAATTGGATTACATACTGTTGCCAACTG
AAGGTTGGAATAAACTTGTCAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCACGAAAGGTGGTTGAACAGGGTATGTTTGTAA
AGCACTGCAAAGTAGAAGTATATCTCACAGAATTGAAGCTATGTGAAAATGGAAACATGAATAATGTTGTAACTCGAAGATTTAGCAAAG
CTGACACAATAGATACAATTGAAAAGGAAATAAGAAAAATCTTCAGTATTCCAGATGAAAAGGAGACCAGATTGTGGAACAAATACATGA
GTAACACATTTGAACCACTGAATAAACCAGACAGCACCATTCAGGATGCTGGTTTATACCAAGGACAGGTATTAGTGATAGAACAGAAAA
ATGAAGATGGAACATGGCCAAGGGGTCCTTCTACTCCTAATGTGAAAAACTCAAATTACTGTCTTCCATCATATACCGCTTATAAGAACT
ATGATTATTCGGAACCTGGAAGAAACAATGAACAGCCAGGCCTCTGTGGCCTAAGTAACTTGGGAAATACGTGTTTCATGAACTCAGCTA
TTCAGTGTTTGAGCAACACACCTCCACTTACTGAGTATTTCCTCAATGATAAGTATCAAGAAGAACTGAATTTTGACAATCCCTTAGGAA
TGAGAGGTGAAATAGCTAAATCTTATGCCGAACTGATCAAGCAAATGTGGTCTGGAAAGTTTAGCTACGTCACCCCAAGAGCCTTTAAGA
CACAGGTAGGACGTTTTGCACCTCAGTTCTCTGGATATCAGCAGCAAGACTGTCAAGAACTGTTAGCTTTCCTATTAGATGGATTACATG
AGGATTTGAATAGAATTAGGAAAAAACCATATATACAATTAAAAGATGCAGATGGAAGGCCAGATAAGGTGGTTGCCGAAGAAGCCTGGG
AAAACCATTTAAAACGAAATGATTCTATCATAGTAGATATATTTCATGGCCTTTTCAAATCAACTTTAGTTTGTCCTGAGTGTGCTAAGA
TTTCAGTAACATTTGATCCTTTTTGTTACTTGACACTTCCATTGCCCATGAAAAAAGAACGCACCTTGGAAGTTTACTTAGTTAGAATGG
ATCCACTTACCAAACCTATGCAGTACAAAGTGGTTGTCCCCAAAATTGGAAACATATTAGATCTTTGTACAGCATTGTCTGCTTTGTCAG
GAATACCTGCAGATAAGATGATAGTTACTGATATATACAATCATAGATTTCACAGAATATTCGCTATGGATGAAAACCTTAGTAGTATTA
TGGAACGGGATGATATTTATGTGTTTGAAATTAACATCAATAGGACAGAAGATACAGAGCACGTGATTATTCCTGTTTGCCTAAGAGAAA
AATTCAGACACTCGAGTTATACCCACCATACTGGTTCTTCACTTTTTGGTCAGCCCTTTCTTATGGCTGTACCACGAAACAATACTGAAG
ACAAACTTTATAATCTCCTGCTCTTGAGAATGTGGGAGTTTGCCTGGCGTGATCCTGAGTTGCCTGAGGTCATTCACATGCTTCAGCACC
AGTTCCCATCTGTTCAGGCAAATGCAGCGGCCTACCTGCAGCACCTGTGCTTTGGTGACAACAAAGTGAAGATGGAGGTGTGTAGGTTAG
GGGGAATCAAGCATCTGGTTGACCTTCTGGACCACAGAGTTTTGGAAGTTCAGAAGAATGCTTGTGGTGCCCTTCGAAACCTCGTTTTTG
GCAAGTCTACAGATGAAAATAAAATAGCAATGAAGAATGTTGGTGGGATACCTGCCTTGTTGCGACTGTTGAGAAAATCTATTGATGCAG
AAGTAAGGGAGCTTGTTACAGGAGTTCTTTGGAATTTATCCTCATGTGATGCTGTAAAAATGACAATCATTCGAGATGCTCTCTCAACCT
TAACAAACACTGTGATTGTTCCACATTCTGGATGGAATAACTCTTCTTTTGATGATGATCATAAAATTAAATTTCAGACTTCACTAGTTC
TGCGTAACACGACAGGTTGCCTAAGGAACCTCAGCTCCGCGGGGGAAGAAGCTCGGAAGCAAATGCGGTCCTGCGAGGGGCTGGTAGACT
CACTGTTGTATGTGATCCACACGTGTGTGAACACATCCGATTACGACAGCAAGACGGTGGAGAACTGCGTGTGCACCCTGAGGAACCTGT
CCTATCGGCTGGAGCTGGAGGTGCCCCAGGCCCGGTTACTGGGACTGAACGAATTGGATGACTTACTAGGAAAAGAGTCTCCCAGCAAAG
ACTCTGAGCCAAGTTGCTGGGGGAAGAAGAAGAAAAAGAAAAAGAGGACTCCGCAAGAAGATCAATGGGATGGAGTTGGTCCTATCCCAG
GACTGTCGAAGTCCCCCAAAGGGGTTGAGATGCTGTGGCACCCATCGGTGGTAAAACCATATCTGACTCTTCTAGCAGAAAGTTCCAACC
CAGCCACCTTGGAAGGCTCTGCAGGGTCTCTCCAGAACCTCTCTGCTGGCAACTGGAAGTTTGCAGCATATATCCGGGCGGCCGTCCGAA
AAGAAAAGGGGCTCCCCATCCTTGTGGAGCTTCTGAGAATGGATAACGATAGAGTTGTTTCTTCCGTGGCAACAGCCTTGAGGAATATGG
CACTAGATGTTCGCAACAAGGAGCTCATAGGCAAATACGCCATGCGAGACCTGGTCAACCGGCTCCCCGGCGGCAATGGCCCCAGTGTCT
TGTCTGATGAGACCATGGCAGCCATCTGCTGTGCTCTGCACGAGGTCACCAGCAAAAACATGGAGAACGCAAAAGCCCTGGCCGACTCAG
GAGGCATAGAGAAGCTGGTGAACATAACCAAAGGCAGGGGCGACAGATCATCTCTGAAAGTGGTGAAGGCAGCAGCCCAGGTCTTGAATA
CATTATGGCAATATCGGGACCTCCGGAGCATTTATAAAAAGGATGGGTGGAATCAGAACCATTTTATTACACCTGTGTCGACATTGGAGC
GAGACCGATTCAAATCACATCCTTCCTTGTCTACCACCAACCAACAGATGTCACCCATCATTCAGTCAGGCTCCAGCAAACCTTCACCAA
TTTACATCAGTTCCTATTCCTCACCAGCAAGAGAACAAAATAGACGGCTACAGCATCAACAGCTGTATTATAGTCAAGATGACTCCAACA
GAAAGAACTTTGATGCATACAGATTGTATTTGCAGTCTCCTCATAGCTATGAAGATCCTTATTTTGATGACCGAGTTCACTTTCCAGCTT
CTACTGATTACTCAACACAGTATGGACTGAAATCGACCACAAATTATGTAGACTTTTATTCCACTAAACGACCTTCTTATAGAGCAGAAC
AGTACCCAGGGTCCCCAGACTCATGGGTGTAGCATCAAGATGCCCAACAGAGGAACTCTTTCTTTCTAACCTTGTTCAGATTGAGGTGAA
AAGTCCATCTTGCTGATTTGATGATTGAAATGTGAAAGTGAAGTGGAAGGAATGAATGAAGTGTGTTTTTTTTTTCTTTTTTGAGGAATT
ATCAGGGAAGTGAGGAAATGTTTGGGAGAGGACTTTCTAAGCTCTATTTAGGTGTTAGATCTAATTACTTATAGATTCTGTAGTCTGGTG
AAGGTGTGGGTGACGTGATGAGAGGTTTGAGAAATGGGTGAAATGAAATGGGGGATATGTAGGTCAAATCAAATTAAAGATGATTTTTTT
AATGTGAATAAAGTTATGTTCTGATAGTTTGTACAGAAAAAATAAAATGGATGCCCATGTTTTATTGCTATTACTAAATGTCAAGATTGT
ATGCTATTATGTCTTGTAAATTTCTTTTGTTGGTGTAAATATGGAAATGCCACATTGGTTAAGTGCCATCATTTGTAATGCAATGTGTCA
CTTGAAAAGAGATTTGAAGAAACTGACAACTTCAAAAACAAATGAGAAGCCCAAGGAACTGTGAGCAATTAAAAGCAAACCGCGACACCC
TTTGTCTCCACCACACATAGTGTACTTTGGAAGCACAACGTCCAGGCTGGTACCGCAGCGCCATGCCCATTCCTCGCCTCATTCATAGGA
CACTTCACTGCCATTTTCTATTCACATAAAAGAAAAATAAATGTGGAAATTTCATCCTTGGAAATGTGTTCTCTATTCTTTTTAAATTTT
CTGTATGTATATGGAAAAGCAGATTTAATAAACACAAATCTAACTGCATGTTGGAAACAGCTTAAATATATCCAACTATTTTGGACTTTT
CCTAGTTTTATATATACTTTGTGAGATGGACCACACCAAAGAATTAAGCTATGAACTTTCCTTCTCTGACAATCTAGGTATTTTTATTTC
TTGGAATCTATTTCAAATCTAGTACCCTTCACAGTTTTATCATGTTTTTCTATATGGCAGCCCGGCCATAACTAAATTGATATAACTAAA
TTGATACCTTTTTTAGGCATCATTTTTAAGAACTCAGTAACTTCATAAGAACAGTGGTTGGGCATTTATTTGGTTGGCACCAATATAATA
AAACAAATTCTAAATTATGATCTTGTTGAGTAATTCCTGGATTAGGAATGGGGTAGGGGAAAGAAGCCCCACAGTAGGGTAGGCAGAGGT
CCCCATAGCACCACACAGCATTACTTGGGAGCTTTTCTCCATCTGTGGAGGCAATGAGGGACACCAGGCCCAAAGTCTGAGGCCTTCTCA
GGTCTTGCAGTTTCCACCCTTCAGTCCTAGCTCCTGGATCTTTGTTGGTGTAAATATGGAAATGCCACATTGGTTAAGTGCCATCATGGA
AAACTAGGAACTAGTTTACCTGTAGCTGTACTAGGAAAACTAGGAACTAACGCCCATGGCAAGTCAAACCCAGAAGTGTTGTCTTAGCTC
AATATACCCTGCAAGTGTAATACAAATCGCAGATTAAAACATTTGTACTTATATTTGTGAGTATATGGAAAGACACCCAAGAGAAAACTG
CGTTTTCTTGCCGAATGGACAGCAGCCCAAGATGAGCATCCAAAGTGAAATGGAAATACCAGTGCGAGCATGAAAGTTCCTAAGATCTGC
AAGCCGGGAGCCCTTCTGGGGTGCCTTCTGAAGAACACTCGAGCCAGCTTGCGGAGTCGACTGCCCAGCTACTGAGCCCTGGCTGCCTCA
TACCTGGCGGAGCTCAGCAGACAGCCCTTGTTAGATGGCAGAGGTCGCCAGATGTTCCTGAGGAACTGGCATCAGGACTTCTGGGACGTA
ACCACTTCAGTTTCCAATCACTGACTTCCCTGAACCTGGTATCTTCAGATCTGGGTTGAAGCTGAAGGCTCAGTTGGGGAATCAGGAAAA
CAAGGGAATCGGAGCCAGCCCAAGCCAACTGACAATAACTTTCTTTTAGTGACTGCATTAGTTTGGGGTAATGCTGTAACAGGCAGCATT
TCAAAAACGGATCCAAATTTGGGTTGAAAATAACTCACCTGGGTCTCCAATCAGACCTAACAGAGCCAGAAAGAGGCCTGTACACGGGGA

>97227_97227_3_USP15-PKP4_USP15_chr12_62783768_ENST00000353364_PKP4_chr2_159497139_ENST00000389757_length(amino acids)=1214AA_BP=586
MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI
LLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLW
NKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCF
MNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLL
DGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVY
LVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVIIPV
CLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMWEFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKME
VCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTIIRD
ALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCT
LRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLA
ESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGN
GPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHFITPV
STLERDRFKSHPSLSTTNQQMSPIIQSGSSKPSPIYISSYSSPAREQNRRLQHQQLYYSQDDSNRKNFDAYRLYLQSPHSYEDPYFDDRV

--------------------------------------------------------------
>97227_97227_4_USP15-PKP4_USP15_chr12_62783768_ENST00000353364_PKP4_chr2_159497139_ENST00000389759_length(transcript)=4603nt_BP=1834nt
GTGGGACGCCATTCCCATAATGCTCTGGGGCGTGCCGCCGCCGTCGCTGCCACCTCCCCTACCGCTAGTGGAAGAAGATGGCGGAAGGCG
GAGCGGCGGATCTGGACACCCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTCCGGAAAGGGGACACCTGGTACCTAGTCGATA
GTCGCTGGTTCAAACAGTGGAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAGATGGGAGATCAAAATGTGTATCCTGGACCCA
TTGATAACTCTGGACTTCTCAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATTGATGAATTGGATTACATACTGTTGCCAACTG
AAGGTTGGAATAAACTTGTCAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCACGAAAGGTGGTTGAACAGGGTATGTTTGTAA
AGCACTGCAAAGTAGAAGTATATCTCACAGAATTGAAGCTATGTGAAAATGGAAACATGAATAATGTTGTAACTCGAAGATTTAGCAAAG
CTGACACAATAGATACAATTGAAAAGGAAATAAGAAAAATCTTCAGTATTCCAGATGAAAAGGAGACCAGATTGTGGAACAAATACATGA
GTAACACATTTGAACCACTGAATAAACCAGACAGCACCATTCAGGATGCTGGTTTATACCAAGGACAGGTATTAGTGATAGAACAGAAAA
ATGAAGATGGAACATGGCCAAGGGGTCCTTCTACTCCTAATGTGAAAAACTCAAATTACTGTCTTCCATCATATACCGCTTATAAGAACT
ATGATTATTCGGAACCTGGAAGAAACAATGAACAGCCAGGCCTCTGTGGCCTAAGTAACTTGGGAAATACGTGTTTCATGAACTCAGCTA
TTCAGTGTTTGAGCAACACACCTCCACTTACTGAGTATTTCCTCAATGATAAGTATCAAGAAGAACTGAATTTTGACAATCCCTTAGGAA
TGAGAGGTGAAATAGCTAAATCTTATGCCGAACTGATCAAGCAAATGTGGTCTGGAAAGTTTAGCTACGTCACCCCAAGAGCCTTTAAGA
CACAGGTAGGACGTTTTGCACCTCAGTTCTCTGGATATCAGCAGCAAGACTGTCAAGAACTGTTAGCTTTCCTATTAGATGGATTACATG
AGGATTTGAATAGAATTAGGAAAAAACCATATATACAATTAAAAGATGCAGATGGAAGGCCAGATAAGGTGGTTGCCGAAGAAGCCTGGG
AAAACCATTTAAAACGAAATGATTCTATCATAGTAGATATATTTCATGGCCTTTTCAAATCAACTTTAGTTTGTCCTGAGTGTGCTAAGA
TTTCAGTAACATTTGATCCTTTTTGTTACTTGACACTTCCATTGCCCATGAAAAAAGAACGCACCTTGGAAGTTTACTTAGTTAGAATGG
ATCCACTTACCAAACCTATGCAGTACAAAGTGGTTGTCCCCAAAATTGGAAACATATTAGATCTTTGTACAGCATTGTCTGCTTTGTCAG
GAATACCTGCAGATAAGATGATAGTTACTGATATATACAATCATAGATTTCACAGAATATTCGCTATGGATGAAAACCTTAGTAGTATTA
TGGAACGGGATGATATTTATGTGTTTGAAATTAACATCAATAGGACAGAAGATACAGAGCACGTGATTATTCCTGTTTGCCTAAGAGAAA
AATTCAGACACTCGAGTTATACCCACCATACTGGTTCTTCACTTTTTGGTCAGCCCTTTCTTATGGCTGTACCACGAAACAATACTGAAG
ACAAACTTTATAATCTCCTGCTCTTGAGAATGTGGGAGTTTGCCTGGCGTGATCCTGAGTTGCCTGAGGTCATTCACATGCTTCAGCACC
AGTTCCCATCTGTTCAGGCAAATGCAGCGGCCTACCTGCAGCACCTGTGCTTTGGTGACAACAAAGTGAAGATGGAGGTGTGTAGGTTAG
GGGGAATCAAGCATCTGGTTGACCTTCTGGACCACAGAGTTTTGGAAGTTCAGAAGAATGCTTGTGGTGCCCTTCGAAACCTCGTTTTTG
GCAAGTCTACAGATGAAAATAAAATAGCAATGAAGAATGTTGGTGGGATACCTGCCTTGTTGCGACTGTTGAGAAAATCTATTGATGCAG
AAGTAAGGGAGCTTGTTACAGGAGTTCTTTGGAATTTATCCTCATGTGATGCTGTAAAAATGACAATCATTCGAGATGCTCTCTCAACCT
TAACAAACACTGTGATTGTTCCACATTCTGGATGGAATAACTCTTCTTTTGATGATGATCATAAAATTAAATTTCAGACTTCACTAGTTC
TGCGTAACACGACAGGTTGCCTAAGGAACCTCAGCTCCGCGGGGGAAGAAGCTCGGAAGCAAATGCGGTCCTGCGAGGGGCTGGTAGACT
CACTGTTGTATGTGATCCACACGTGTGTGAACACATCCGATTACGACAGCAAGACGGTGGAGAACTGCGTGTGCACCCTGAGGAACCTGT
CCTATCGGCTGGAGCTGGAGGTGCCCCAGGCCCGGTTACTGGGACTGAACGAATTGGATGACTTACTAGGAAAAGAGTCTCCCAGCAAAG
ACTCTGAGCCAAGTTGCTGGGGGAAGAAGAAGAAAAAGAAAAAGAGGACTCCGCAAGAAGATCAATGGGATGGAGTTGGTCCTATCCCAG
GACTGTCGAAGTCCCCCAAAGGGGTTGAGATGCTGTGGCACCCATCGGTGGTAAAACCATATCTGACTCTTCTAGCAGAAAGTTCCAACC
CAGCCACCTTGGAAGGCTCTGCAGGGTCTCTCCAGAACCTCTCTGCTGGCAACTGGAAGTTTGCAGCATATATCCGGGCGGCCGTCCGAA
AAGAAAAGGGGCTCCCCATCCTTGTGGAGCTTCTGAGAATGGATAACGATAGAGTTGTTTCTTCCGTGGCAACAGCCTTGAGGAATATGG
CACTAGATGTTCGCAACAAGGAGCTCATAGGCAAATACGCCATGCGAGACCTGGTCAACCGGCTCCCCGGCGGCAATGGCCCCAGTGTCT
TGTCTGATGAGACCATGGCAGCCATCTGCTGTGCTCTGCACGAGGTCACCAGCAAAAACATGGAGAACGCAAAAGCCCTGGCCGACTCAG
GAGGCATAGAGAAGCTGGTGAACATAACCAAAGGCAGGGGCGACAGATCATCTCTGAAAGTGGTGAAGGCAGCAGCCCAGGTCTTGAATA
CATTATGGCAATATCGGGACCTCCGGAGCATTTATAAAAAGGATGGGTGGAATCAGAACCATTTTATTACACCTGTGTCGACATTGGAGC
GAGACCGATTCAAATCACATCCTTCCTTGTCTACCACCAACCAACAGATGTCACCCATCATTCAGTCAGTCGGCAGCACCTCTTCCTCAC
CAGCACTGTTAGGAATCAGAGACCCTCGCTCTGAATACGATAGGACCCAGCCACCTATGCAGTATTACAATAGCCAAGGGGATGCCACAC
ATAAAGGCCTGTACCCTGGCTCCAGCAAACCTTCACCAATTTACATCAGTTCCTATTCCTCACCAGCAAGAGAACAAAATAGACGGCTAC
AGCATCAACAGCTGTATTATAGTCAAGATGACTCCAACAGAAAGAACTTTGATGCATACAGATTGTATTTGCAGTCTCCTCATAGCTATG
AAGATCCTTATTTTGATGACCGAGTTCACTTTCCAGCTTCTACTGATTACTCAACACAGTATGGACTGAAATCGACCACAAATTATGTAG
ACTTTTATTCCACTAAACGACCTTCTTATAGAGCAGAACAGTACCCAGGGTCCCCAGACTCATGGGTGTAGCATCAAGATGCCCAACAGA
GGAACTCTTTCTTTCTAACCTTGTTCAGATTGAGGTGAAAAGTCCATCTTGCTGATTTGATGATTGAAATGTGAAAGTGAAGTGGAAGGA
ATGAATGAAGTGTGTTTTTTTTTTCTTTTTTGAGGAATTATCAGGGAAGTGAGGAAATGTTTGGGAGAGGACTTTCTAAGCTCTATTTAG
GTGTTAGATCTAATTACTTATAGATTCTGTAGTCTGGTGAAGGTGTGGGTGACGTGATGAGAGGTTTGAGAAATGGGTGAAATGAAATGG
GGGATATGTAGGTCAAATCAAATTAAAGATGATTTTTTTAATGTGAATAAAGTTATGTTCTGATAGTTTGTACAGAAAAAATAAAATGGA
TGCCCATGTTTTATTGCTATTACTAAATGTCAAGATTGTATGCTATTATGTCTTGTAAATTTCTTTTGTTGGTGTAAATATGGAAATGCC
ACATTGGTTAAGTGCCATCATTTGTAATGCAATGTGTCACTTGAAAAGAGATTTGAAGAAACTGACAACTTCAAAAACAAATGAGAAGCC
CAAGGAACTGTGAGCAATTAAAAGCAAACCGCGACACCCTTTGTCTCCACCACACATAGTGTACTTTGGAAGCACAACGTCCAGGCTGGT
ACCGCAGCGCCATGCCCATTCCTCGCCTCATTCATAGGACACTTCACTGCCATTTTCTATTCACATAAAAGAAAAATAAATGTGGAAATT

>97227_97227_4_USP15-PKP4_USP15_chr12_62783768_ENST00000353364_PKP4_chr2_159497139_ENST00000389759_length(amino acids)=1257AA_BP=586
MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI
LLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLW
NKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCF
MNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLL
DGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVY
LVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVIIPV
CLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMWEFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKME
VCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTIIRD
ALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCT
LRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLA
ESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGN
GPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHFITPV
STLERDRFKSHPSLSTTNQQMSPIIQSVGSTSSSPALLGIRDPRSEYDRTQPPMQYYNSQGDATHKGLYPGSSKPSPIYISSYSSPAREQ

--------------------------------------------------------------
>97227_97227_5_USP15-PKP4_USP15_chr12_62783768_ENST00000393654_PKP4_chr2_159497139_ENST00000389757_length(transcript)=5868nt_BP=1778nt
TGGAAGAAGATGGCGGAAGGCGGAGCGGCGGATCTGGACACCCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTCCGGAAAGGG
GACACCTGGTACCTAGTCGATAGTCGCTGGTTCAAACAGTGGAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAGATGGGAGAT
CAAAATGTGTATCCTGGACCCATTGATAACTCTGGACTTCTCAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATTGATGAATTG
GATTACATACTGTTGCCAACTGAAGGTTGGAATAAACTTGTCAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCACGAAAGGTG
GTTGAACAGGGTATGTTTGTAAAGCACTGCAAAGTAGAAGTATATCTCACAGAATTGAAGCTATGTGAAAATGGAAACATGAATAATGTT
GTAACTCGAAGATTTAGCAAAGCTGACACAATAGATACAATTGAAAAGGAAATAAGAAAAATCTTCAGTATTCCAGATGAAAAGGAGACC
AGATTGTGGAACAAATACATGAGTAACACATTTGAACCACTGAATAAACCAGACAGCACCATTCAGGATGCTGGTTTATACCAAGGACAG
GTATTGTTTATTGTATTAGTGATAGAACAGAAAAATGAAGATGGAACATGGCCAAGGGGTCCTTCTACTCCTAATGTGAAAAACTCAAAT
TACTGTCTTCCATCATATACCGCTTATAAGAACTATGATTATTCGGAACCTGGAAGAAACAATGAACAGCCAGGCCTCTGTGGCCTAAGT
AACTTGGGAAATACGTGTTTCATGAACTCAGCTATTCAGTGTTTGAGCAACACACCTCCACTTACTGAGTATTTCCTCAATGATAAGTAT
CAAGAAGAACTGAATTTTGACAATCCCTTAGGAATGAGAGGTGAAATAGCTAAATCTTATGCCGAACTGATCAAGCAAATGTGGTCTGGA
AAGTTTAGCTACGTCACCCCAAGAGCCTTTAAGACACAGGTAGGACGTTTTGCACCTCAGTTCTCTGGATATCAGCAGCAAGACTGTCAA
GAACTGTTAGCTTTCCTATTAGATGGATTACATGAGGATTTGAATAGAATTAGGAAAAAACCATATATACAATTAAAAGATGCAGATGGA
AGGCCAGATAAGGTGGTTGCCGAAGAAGCCTGGGAAAACCATTTAAAACGAAATGATTCTATCATAGTAGATATATTTCATGGCCTTTTC
AAATCAACTTTAGTTTGTCCTGAGTGTGCTAAGATTTCAGTAACATTTGATCCTTTTTGTTACTTGACACTTCCATTGCCCATGAAAAAA
GAACGCACCTTGGAAGTTTACTTAGTTAGAATGGATCCACTTACCAAACCTATGCAGTACAAAGTGGTTGTCCCCAAAATTGGAAACATA
TTAGATCTTTGTACAGCATTGTCTGCTTTGTCAGGAATACCTGCAGATAAGATGATAGTTACTGATATATACAATCATAGATTTCACAGA
ATATTCGCTATGGATGAAAACCTTAGTAGTATTATGGAACGGGATGATATTTATGTGTTTGAAATTAACATCAATAGGACAGAAGATACA
GAGCACGTGATTATTCCTGTTTGCCTAAGAGAAAAATTCAGACACTCGAGTTATACCCACCATACTGGTTCTTCACTTTTTGGTCAGCCC
TTTCTTATGGCTGTACCACGAAACAATACTGAAGACAAACTTTATAATCTCCTGCTCTTGAGAATGTGGGAGTTTGCCTGGCGTGATCCT
GAGTTGCCTGAGGTCATTCACATGCTTCAGCACCAGTTCCCATCTGTTCAGGCAAATGCAGCGGCCTACCTGCAGCACCTGTGCTTTGGT
GACAACAAAGTGAAGATGGAGGTGTGTAGGTTAGGGGGAATCAAGCATCTGGTTGACCTTCTGGACCACAGAGTTTTGGAAGTTCAGAAG
AATGCTTGTGGTGCCCTTCGAAACCTCGTTTTTGGCAAGTCTACAGATGAAAATAAAATAGCAATGAAGAATGTTGGTGGGATACCTGCC
TTGTTGCGACTGTTGAGAAAATCTATTGATGCAGAAGTAAGGGAGCTTGTTACAGGAGTTCTTTGGAATTTATCCTCATGTGATGCTGTA
AAAATGACAATCATTCGAGATGCTCTCTCAACCTTAACAAACACTGTGATTGTTCCACATTCTGGATGGAATAACTCTTCTTTTGATGAT
GATCATAAAATTAAATTTCAGACTTCACTAGTTCTGCGTAACACGACAGGTTGCCTAAGGAACCTCAGCTCCGCGGGGGAAGAAGCTCGG
AAGCAAATGCGGTCCTGCGAGGGGCTGGTAGACTCACTGTTGTATGTGATCCACACGTGTGTGAACACATCCGATTACGACAGCAAGACG
GTGGAGAACTGCGTGTGCACCCTGAGGAACCTGTCCTATCGGCTGGAGCTGGAGGTGCCCCAGGCCCGGTTACTGGGACTGAACGAATTG
GATGACTTACTAGGAAAAGAGTCTCCCAGCAAAGACTCTGAGCCAAGTTGCTGGGGGAAGAAGAAGAAAAAGAAAAAGAGGACTCCGCAA
GAAGATCAATGGGATGGAGTTGGTCCTATCCCAGGACTGTCGAAGTCCCCCAAAGGGGTTGAGATGCTGTGGCACCCATCGGTGGTAAAA
CCATATCTGACTCTTCTAGCAGAAAGTTCCAACCCAGCCACCTTGGAAGGCTCTGCAGGGTCTCTCCAGAACCTCTCTGCTGGCAACTGG
AAGTTTGCAGCATATATCCGGGCGGCCGTCCGAAAAGAAAAGGGGCTCCCCATCCTTGTGGAGCTTCTGAGAATGGATAACGATAGAGTT
GTTTCTTCCGTGGCAACAGCCTTGAGGAATATGGCACTAGATGTTCGCAACAAGGAGCTCATAGGCAAATACGCCATGCGAGACCTGGTC
AACCGGCTCCCCGGCGGCAATGGCCCCAGTGTCTTGTCTGATGAGACCATGGCAGCCATCTGCTGTGCTCTGCACGAGGTCACCAGCAAA
AACATGGAGAACGCAAAAGCCCTGGCCGACTCAGGAGGCATAGAGAAGCTGGTGAACATAACCAAAGGCAGGGGCGACAGATCATCTCTG
AAAGTGGTGAAGGCAGCAGCCCAGGTCTTGAATACATTATGGCAATATCGGGACCTCCGGAGCATTTATAAAAAGGATGGGTGGAATCAG
AACCATTTTATTACACCTGTGTCGACATTGGAGCGAGACCGATTCAAATCACATCCTTCCTTGTCTACCACCAACCAACAGATGTCACCC
ATCATTCAGTCAGGCTCCAGCAAACCTTCACCAATTTACATCAGTTCCTATTCCTCACCAGCAAGAGAACAAAATAGACGGCTACAGCAT
CAACAGCTGTATTATAGTCAAGATGACTCCAACAGAAAGAACTTTGATGCATACAGATTGTATTTGCAGTCTCCTCATAGCTATGAAGAT
CCTTATTTTGATGACCGAGTTCACTTTCCAGCTTCTACTGATTACTCAACACAGTATGGACTGAAATCGACCACAAATTATGTAGACTTT
TATTCCACTAAACGACCTTCTTATAGAGCAGAACAGTACCCAGGGTCCCCAGACTCATGGGTGTAGCATCAAGATGCCCAACAGAGGAAC
TCTTTCTTTCTAACCTTGTTCAGATTGAGGTGAAAAGTCCATCTTGCTGATTTGATGATTGAAATGTGAAAGTGAAGTGGAAGGAATGAA
TGAAGTGTGTTTTTTTTTTCTTTTTTGAGGAATTATCAGGGAAGTGAGGAAATGTTTGGGAGAGGACTTTCTAAGCTCTATTTAGGTGTT
AGATCTAATTACTTATAGATTCTGTAGTCTGGTGAAGGTGTGGGTGACGTGATGAGAGGTTTGAGAAATGGGTGAAATGAAATGGGGGAT
ATGTAGGTCAAATCAAATTAAAGATGATTTTTTTAATGTGAATAAAGTTATGTTCTGATAGTTTGTACAGAAAAAATAAAATGGATGCCC
ATGTTTTATTGCTATTACTAAATGTCAAGATTGTATGCTATTATGTCTTGTAAATTTCTTTTGTTGGTGTAAATATGGAAATGCCACATT
GGTTAAGTGCCATCATTTGTAATGCAATGTGTCACTTGAAAAGAGATTTGAAGAAACTGACAACTTCAAAAACAAATGAGAAGCCCAAGG
AACTGTGAGCAATTAAAAGCAAACCGCGACACCCTTTGTCTCCACCACACATAGTGTACTTTGGAAGCACAACGTCCAGGCTGGTACCGC
AGCGCCATGCCCATTCCTCGCCTCATTCATAGGACACTTCACTGCCATTTTCTATTCACATAAAAGAAAAATAAATGTGGAAATTTCATC
CTTGGAAATGTGTTCTCTATTCTTTTTAAATTTTCTGTATGTATATGGAAAAGCAGATTTAATAAACACAAATCTAACTGCATGTTGGAA
ACAGCTTAAATATATCCAACTATTTTGGACTTTTCCTAGTTTTATATATACTTTGTGAGATGGACCACACCAAAGAATTAAGCTATGAAC
TTTCCTTCTCTGACAATCTAGGTATTTTTATTTCTTGGAATCTATTTCAAATCTAGTACCCTTCACAGTTTTATCATGTTTTTCTATATG
GCAGCCCGGCCATAACTAAATTGATATAACTAAATTGATACCTTTTTTAGGCATCATTTTTAAGAACTCAGTAACTTCATAAGAACAGTG
GTTGGGCATTTATTTGGTTGGCACCAATATAATAAAACAAATTCTAAATTATGATCTTGTTGAGTAATTCCTGGATTAGGAATGGGGTAG
GGGAAAGAAGCCCCACAGTAGGGTAGGCAGAGGTCCCCATAGCACCACACAGCATTACTTGGGAGCTTTTCTCCATCTGTGGAGGCAATG
AGGGACACCAGGCCCAAAGTCTGAGGCCTTCTCAGGTCTTGCAGTTTCCACCCTTCAGTCCTAGCTCCTGGATCTTTGTTGGTGTAAATA
TGGAAATGCCACATTGGTTAAGTGCCATCATGGAAAACTAGGAACTAGTTTACCTGTAGCTGTACTAGGAAAACTAGGAACTAACGCCCA
TGGCAAGTCAAACCCAGAAGTGTTGTCTTAGCTCAATATACCCTGCAAGTGTAATACAAATCGCAGATTAAAACATTTGTACTTATATTT
GTGAGTATATGGAAAGACACCCAAGAGAAAACTGCGTTTTCTTGCCGAATGGACAGCAGCCCAAGATGAGCATCCAAAGTGAAATGGAAA
TACCAGTGCGAGCATGAAAGTTCCTAAGATCTGCAAGCCGGGAGCCCTTCTGGGGTGCCTTCTGAAGAACACTCGAGCCAGCTTGCGGAG
TCGACTGCCCAGCTACTGAGCCCTGGCTGCCTCATACCTGGCGGAGCTCAGCAGACAGCCCTTGTTAGATGGCAGAGGTCGCCAGATGTT
CCTGAGGAACTGGCATCAGGACTTCTGGGACGTAACCACTTCAGTTTCCAATCACTGACTTCCCTGAACCTGGTATCTTCAGATCTGGGT
TGAAGCTGAAGGCTCAGTTGGGGAATCAGGAAAACAAGGGAATCGGAGCCAGCCCAAGCCAACTGACAATAACTTTCTTTTAGTGACTGC
ATTAGTTTGGGGTAATGCTGTAACAGGCAGCATTTCAAAAACGGATCCAAATTTGGGTTGAAAATAACTCACCTGGGTCTCCAATCAGAC
CTAACAGAGCCAGAAAGAGGCCTGTACACGGGGACTGGGCAGAAGATCTAATGCCGTTTAAGACTCCTCCCTTGAGACCAGAGAAAAGAA

>97227_97227_5_USP15-PKP4_USP15_chr12_62783768_ENST00000393654_PKP4_chr2_159497139_ENST00000389757_length(amino acids)=1218AA_BP=590
MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI
LLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLW
NKYMSNTFEPLNKPDSTIQDAGLYQGQVLFIVLVIEQKNEDGTWPRGPSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLG
NTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELL
AFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERT
LEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHV
IIPVCLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMWEFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNK
VKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMT
IIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVEN
CVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYL
TLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRL
PGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHF
ITPVSTLERDRFKSHPSLSTTNQQMSPIIQSGSSKPSPIYISSYSSPAREQNRRLQHQQLYYSQDDSNRKNFDAYRLYLQSPHSYEDPYF

--------------------------------------------------------------
>97227_97227_6_USP15-PKP4_USP15_chr12_62783768_ENST00000393654_PKP4_chr2_159497139_ENST00000389759_length(transcript)=4547nt_BP=1778nt
TGGAAGAAGATGGCGGAAGGCGGAGCGGCGGATCTGGACACCCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTCCGGAAAGGG
GACACCTGGTACCTAGTCGATAGTCGCTGGTTCAAACAGTGGAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAGATGGGAGAT
CAAAATGTGTATCCTGGACCCATTGATAACTCTGGACTTCTCAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATTGATGAATTG
GATTACATACTGTTGCCAACTGAAGGTTGGAATAAACTTGTCAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCACGAAAGGTG
GTTGAACAGGGTATGTTTGTAAAGCACTGCAAAGTAGAAGTATATCTCACAGAATTGAAGCTATGTGAAAATGGAAACATGAATAATGTT
GTAACTCGAAGATTTAGCAAAGCTGACACAATAGATACAATTGAAAAGGAAATAAGAAAAATCTTCAGTATTCCAGATGAAAAGGAGACC
AGATTGTGGAACAAATACATGAGTAACACATTTGAACCACTGAATAAACCAGACAGCACCATTCAGGATGCTGGTTTATACCAAGGACAG
GTATTGTTTATTGTATTAGTGATAGAACAGAAAAATGAAGATGGAACATGGCCAAGGGGTCCTTCTACTCCTAATGTGAAAAACTCAAAT
TACTGTCTTCCATCATATACCGCTTATAAGAACTATGATTATTCGGAACCTGGAAGAAACAATGAACAGCCAGGCCTCTGTGGCCTAAGT
AACTTGGGAAATACGTGTTTCATGAACTCAGCTATTCAGTGTTTGAGCAACACACCTCCACTTACTGAGTATTTCCTCAATGATAAGTAT
CAAGAAGAACTGAATTTTGACAATCCCTTAGGAATGAGAGGTGAAATAGCTAAATCTTATGCCGAACTGATCAAGCAAATGTGGTCTGGA
AAGTTTAGCTACGTCACCCCAAGAGCCTTTAAGACACAGGTAGGACGTTTTGCACCTCAGTTCTCTGGATATCAGCAGCAAGACTGTCAA
GAACTGTTAGCTTTCCTATTAGATGGATTACATGAGGATTTGAATAGAATTAGGAAAAAACCATATATACAATTAAAAGATGCAGATGGA
AGGCCAGATAAGGTGGTTGCCGAAGAAGCCTGGGAAAACCATTTAAAACGAAATGATTCTATCATAGTAGATATATTTCATGGCCTTTTC
AAATCAACTTTAGTTTGTCCTGAGTGTGCTAAGATTTCAGTAACATTTGATCCTTTTTGTTACTTGACACTTCCATTGCCCATGAAAAAA
GAACGCACCTTGGAAGTTTACTTAGTTAGAATGGATCCACTTACCAAACCTATGCAGTACAAAGTGGTTGTCCCCAAAATTGGAAACATA
TTAGATCTTTGTACAGCATTGTCTGCTTTGTCAGGAATACCTGCAGATAAGATGATAGTTACTGATATATACAATCATAGATTTCACAGA
ATATTCGCTATGGATGAAAACCTTAGTAGTATTATGGAACGGGATGATATTTATGTGTTTGAAATTAACATCAATAGGACAGAAGATACA
GAGCACGTGATTATTCCTGTTTGCCTAAGAGAAAAATTCAGACACTCGAGTTATACCCACCATACTGGTTCTTCACTTTTTGGTCAGCCC
TTTCTTATGGCTGTACCACGAAACAATACTGAAGACAAACTTTATAATCTCCTGCTCTTGAGAATGTGGGAGTTTGCCTGGCGTGATCCT
GAGTTGCCTGAGGTCATTCACATGCTTCAGCACCAGTTCCCATCTGTTCAGGCAAATGCAGCGGCCTACCTGCAGCACCTGTGCTTTGGT
GACAACAAAGTGAAGATGGAGGTGTGTAGGTTAGGGGGAATCAAGCATCTGGTTGACCTTCTGGACCACAGAGTTTTGGAAGTTCAGAAG
AATGCTTGTGGTGCCCTTCGAAACCTCGTTTTTGGCAAGTCTACAGATGAAAATAAAATAGCAATGAAGAATGTTGGTGGGATACCTGCC
TTGTTGCGACTGTTGAGAAAATCTATTGATGCAGAAGTAAGGGAGCTTGTTACAGGAGTTCTTTGGAATTTATCCTCATGTGATGCTGTA
AAAATGACAATCATTCGAGATGCTCTCTCAACCTTAACAAACACTGTGATTGTTCCACATTCTGGATGGAATAACTCTTCTTTTGATGAT
GATCATAAAATTAAATTTCAGACTTCACTAGTTCTGCGTAACACGACAGGTTGCCTAAGGAACCTCAGCTCCGCGGGGGAAGAAGCTCGG
AAGCAAATGCGGTCCTGCGAGGGGCTGGTAGACTCACTGTTGTATGTGATCCACACGTGTGTGAACACATCCGATTACGACAGCAAGACG
GTGGAGAACTGCGTGTGCACCCTGAGGAACCTGTCCTATCGGCTGGAGCTGGAGGTGCCCCAGGCCCGGTTACTGGGACTGAACGAATTG
GATGACTTACTAGGAAAAGAGTCTCCCAGCAAAGACTCTGAGCCAAGTTGCTGGGGGAAGAAGAAGAAAAAGAAAAAGAGGACTCCGCAA
GAAGATCAATGGGATGGAGTTGGTCCTATCCCAGGACTGTCGAAGTCCCCCAAAGGGGTTGAGATGCTGTGGCACCCATCGGTGGTAAAA
CCATATCTGACTCTTCTAGCAGAAAGTTCCAACCCAGCCACCTTGGAAGGCTCTGCAGGGTCTCTCCAGAACCTCTCTGCTGGCAACTGG
AAGTTTGCAGCATATATCCGGGCGGCCGTCCGAAAAGAAAAGGGGCTCCCCATCCTTGTGGAGCTTCTGAGAATGGATAACGATAGAGTT
GTTTCTTCCGTGGCAACAGCCTTGAGGAATATGGCACTAGATGTTCGCAACAAGGAGCTCATAGGCAAATACGCCATGCGAGACCTGGTC
AACCGGCTCCCCGGCGGCAATGGCCCCAGTGTCTTGTCTGATGAGACCATGGCAGCCATCTGCTGTGCTCTGCACGAGGTCACCAGCAAA
AACATGGAGAACGCAAAAGCCCTGGCCGACTCAGGAGGCATAGAGAAGCTGGTGAACATAACCAAAGGCAGGGGCGACAGATCATCTCTG
AAAGTGGTGAAGGCAGCAGCCCAGGTCTTGAATACATTATGGCAATATCGGGACCTCCGGAGCATTTATAAAAAGGATGGGTGGAATCAG
AACCATTTTATTACACCTGTGTCGACATTGGAGCGAGACCGATTCAAATCACATCCTTCCTTGTCTACCACCAACCAACAGATGTCACCC
ATCATTCAGTCAGTCGGCAGCACCTCTTCCTCACCAGCACTGTTAGGAATCAGAGACCCTCGCTCTGAATACGATAGGACCCAGCCACCT
ATGCAGTATTACAATAGCCAAGGGGATGCCACACATAAAGGCCTGTACCCTGGCTCCAGCAAACCTTCACCAATTTACATCAGTTCCTAT
TCCTCACCAGCAAGAGAACAAAATAGACGGCTACAGCATCAACAGCTGTATTATAGTCAAGATGACTCCAACAGAAAGAACTTTGATGCA
TACAGATTGTATTTGCAGTCTCCTCATAGCTATGAAGATCCTTATTTTGATGACCGAGTTCACTTTCCAGCTTCTACTGATTACTCAACA
CAGTATGGACTGAAATCGACCACAAATTATGTAGACTTTTATTCCACTAAACGACCTTCTTATAGAGCAGAACAGTACCCAGGGTCCCCA
GACTCATGGGTGTAGCATCAAGATGCCCAACAGAGGAACTCTTTCTTTCTAACCTTGTTCAGATTGAGGTGAAAAGTCCATCTTGCTGAT
TTGATGATTGAAATGTGAAAGTGAAGTGGAAGGAATGAATGAAGTGTGTTTTTTTTTTCTTTTTTGAGGAATTATCAGGGAAGTGAGGAA
ATGTTTGGGAGAGGACTTTCTAAGCTCTATTTAGGTGTTAGATCTAATTACTTATAGATTCTGTAGTCTGGTGAAGGTGTGGGTGACGTG
ATGAGAGGTTTGAGAAATGGGTGAAATGAAATGGGGGATATGTAGGTCAAATCAAATTAAAGATGATTTTTTTAATGTGAATAAAGTTAT
GTTCTGATAGTTTGTACAGAAAAAATAAAATGGATGCCCATGTTTTATTGCTATTACTAAATGTCAAGATTGTATGCTATTATGTCTTGT
AAATTTCTTTTGTTGGTGTAAATATGGAAATGCCACATTGGTTAAGTGCCATCATTTGTAATGCAATGTGTCACTTGAAAAGAGATTTGA
AGAAACTGACAACTTCAAAAACAAATGAGAAGCCCAAGGAACTGTGAGCAATTAAAAGCAAACCGCGACACCCTTTGTCTCCACCACACA
TAGTGTACTTTGGAAGCACAACGTCCAGGCTGGTACCGCAGCGCCATGCCCATTCCTCGCCTCATTCATAGGACACTTCACTGCCATTTT

>97227_97227_6_USP15-PKP4_USP15_chr12_62783768_ENST00000393654_PKP4_chr2_159497139_ENST00000389759_length(amino acids)=1261AA_BP=590
MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI
LLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLW
NKYMSNTFEPLNKPDSTIQDAGLYQGQVLFIVLVIEQKNEDGTWPRGPSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLG
NTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELL
AFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERT
LEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHV
IIPVCLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMWEFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNK
VKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMT
IIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVEN
CVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYL
TLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRL
PGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHF
ITPVSTLERDRFKSHPSLSTTNQQMSPIIQSVGSTSSSPALLGIRDPRSEYDRTQPPMQYYNSQGDATHKGLYPGSSKPSPIYISSYSSP
AREQNRRLQHQQLYYSQDDSNRKNFDAYRLYLQSPHSYEDPYFDDRVHFPASTDYSTQYGLKSTTNYVDFYSTKRPSYRAEQYPGSPDSW

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Fusion Gene PPI Analysis for USP15-PKP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP15-PKP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP15-PKP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource