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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:USP15-PPM1H (FusionGDB2 ID:97228) |
Fusion Gene Summary for USP15-PPM1H |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP15-PPM1H | Fusion gene ID: 97228 | Hgene | Tgene | Gene symbol | USP15 | PPM1H | Gene ID | 9958 | 57460 |
| Gene name | ubiquitin specific peptidase 15 | protein phosphatase, Mg2+/Mn2+ dependent 1H | |
| Synonyms | UNPH-2|UNPH4 | ARHCL1|NERPP-2C|URCC2 | |
| Cytomap | 12q14.1 | 12q14.1-q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 15deubiquitinating enzyme 15ubiquitin thioesterase 15ubiquitin thiolesterase 15ubiquitin-specific-processing protease 15 | protein phosphatase 1Hneurite extension-related protein phosphatase related to PP2Cprotein phosphatase 1H (PP2C domain containing)ras homolog gene family, member C like 1 | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000550632, ENST00000280377, ENST00000312635, ENST00000353364, ENST00000393654, | ENST00000228705, ENST00000551214, | |
| Fusion gene scores | * DoF score | 23 X 14 X 12=3864 | 12 X 10 X 6=720 |
| # samples | 26 | 11 | |
| ** MAII score | log2(26/3864*10)=-3.89351156580732 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/720*10)=-2.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: USP15 [Title/Abstract] AND PPM1H [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PPM1H(63328272)-USP15(62687960), # samples:3 USP15(62696701)-PPM1H(63114069), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | PPM1H-USP15 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. PPM1H-USP15 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | USP15 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 21947082 |
| Hgene | USP15 | GO:0016579 | protein deubiquitination | 16005295|22344298|27368102 |
| Hgene | USP15 | GO:0030509 | BMP signaling pathway | 21947082 |
| Hgene | USP15 | GO:0035520 | monoubiquitinated protein deubiquitination | 21947082|24399297 |
| Hgene | USP15 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination | 24526689 |
| Hgene | USP15 | GO:1900246 | positive regulation of RIG-I signaling pathway | 24399297 |
| Fusion gene breakpoints across USP15 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PPM1H (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | ERR315444 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - |
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Fusion Gene ORF analysis for USP15-PPM1H |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000550632 | ENST00000228705 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - |
| 3UTR-5UTR | ENST00000550632 | ENST00000551214 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - |
| 5CDS-5UTR | ENST00000280377 | ENST00000551214 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - |
| 5CDS-5UTR | ENST00000312635 | ENST00000551214 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - |
| 5CDS-5UTR | ENST00000353364 | ENST00000551214 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - |
| 5CDS-5UTR | ENST00000393654 | ENST00000551214 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - |
| In-frame | ENST00000280377 | ENST00000228705 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - |
| In-frame | ENST00000312635 | ENST00000228705 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - |
| In-frame | ENST00000353364 | ENST00000228705 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - |
| In-frame | ENST00000393654 | ENST00000228705 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000353364 | USP15 | chr12 | 62696701 | + | ENST00000228705 | PPM1H | chr12 | 63114069 | - | 5523 | 425 | 77 | 1015 | 312 |
| ENST00000280377 | USP15 | chr12 | 62696701 | + | ENST00000228705 | PPM1H | chr12 | 63114069 | - | 5504 | 406 | 58 | 996 | 312 |
| ENST00000393654 | USP15 | chr12 | 62696701 | + | ENST00000228705 | PPM1H | chr12 | 63114069 | - | 5455 | 357 | 9 | 947 | 312 |
| ENST00000312635 | USP15 | chr12 | 62696701 | + | ENST00000228705 | PPM1H | chr12 | 63114069 | - | 5464 | 366 | 18 | 956 | 312 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000353364 | ENST00000228705 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - | 0.000115548 | 0.9998845 |
| ENST00000280377 | ENST00000228705 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - | 0.000118749 | 0.99988127 |
| ENST00000393654 | ENST00000228705 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - | 0.000115053 | 0.99988496 |
| ENST00000312635 | ENST00000228705 | USP15 | chr12 | 62696701 | + | PPM1H | chr12 | 63114069 | - | 0.000115281 | 0.9998847 |
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Fusion Genomic Features for USP15-PPM1H |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for USP15-PPM1H |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:63328272/chr12:62687960) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | USP15 | chr12:62696701 | chr12:63114069 | ENST00000280377 | + | 3 | 22 | 7_118 | 116 | 982.0 | Domain | DUSP |
| Hgene | USP15 | chr12:62696701 | chr12:63114069 | ENST00000312635 | + | 3 | 7 | 7_118 | 116 | 236.0 | Domain | DUSP |
| Hgene | USP15 | chr12:62696701 | chr12:63114069 | ENST00000353364 | + | 3 | 21 | 7_118 | 116 | 953.0 | Domain | DUSP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | USP15 | chr12:62696701 | chr12:63114069 | ENST00000280377 | + | 3 | 22 | 289_933 | 116 | 982.0 | Domain | USP |
| Hgene | USP15 | chr12:62696701 | chr12:63114069 | ENST00000312635 | + | 3 | 7 | 289_933 | 116 | 236.0 | Domain | USP |
| Hgene | USP15 | chr12:62696701 | chr12:63114069 | ENST00000353364 | + | 3 | 21 | 289_933 | 116 | 953.0 | Domain | USP |
| Tgene | PPM1H | chr12:62696701 | chr12:63114069 | ENST00000228705 | 4 | 10 | 77_507 | 318 | 515.0 | Domain | PPM-type phosphatase |
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Fusion Gene Sequence for USP15-PPM1H |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >97228_97228_1_USP15-PPM1H_USP15_chr12_62696701_ENST00000280377_PPM1H_chr12_63114069_ENST00000228705_length(transcript)=5504nt_BP=406nt ATGCTCTGGGGCGTGCCGCCGCCGTCGCTGCCACCTCCCCTACCGCTAGTGGAAGAAGATGGCGGAAGGCGGAGCGGCGGATCTGGACAC CCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTCCGGAAAGGGGACACCTGGTACCTAGTCGATAGTCGCTGGTTCAAACAGTG GAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAGATGGGAGATCAAAATGTGTATCCTGGACCCATTGATAACTCTGGACTTCT CAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATTGATGAATTGGATTACATACTGTTGCCAACTGAAGGTTGGAATAAACTTGT CAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCACGAAAGGCATTCATGCAGCCTCACTTGCTGGGAAATGAGTTCACACATTT GGAGTTTCCAAGGAGAGTACAGAGAAAGGAGCTTGGAAAGAAGATGCTCTACAGGGACTTTAATATGACAGGCTGGGCATACAAAACCAT TGAGGATGAGGACTTGAAGTTCCCCCTTATATATGGAGAAGGCAAGAAGGCCCGGGTAATGGCAACTATTGGAGTGACCAGGGGACTTGG GGACCATGACCTGAAGGTGCATGACTCCAACATCTACATTAAACCATTCCTGTCTTCAGCTCCAGAGGTAAGAATCTACGATCTTTCAAA ATATGATCATGGATCAGATGATGTGCTGATCTTGGCCACTGATGGACTCTGGGACGTTTTATCAAATGAAGAAGTAGCAGAAGCAATCAC TCAGTTTCTTCCTAACTGTGATCCAGATGATCCTCACAGGTACACACTGGCAGCTCAGGACCTGGTGATGCGTGCCCGGGGTGTGCTGAA GGACAGAGGATGGCGGATATCTAATGACCGACTGGGCTCAGGAGACGACATTTCTGTATATGTCATTCCTTTAATACATGGAAACAAGCT GTCATGAAAATGGCCCAGGGGATTGGGAGGACAGAGGGGAAGAAAGCTGGGATGCCTCTTGGCAGGACGGAACTGGGAAGTGCCCCAGCT GAGTTCCAAGTGATGCAGTCTCTTCCCAGCCCAAGCGGGGAGTTCATGGCCAAAAGACTATGCTTCAAGATGACCCTTTGGTTTCCATTT CTTCTTTAGTAACAGGTCAACTCAACAAGAGCAAAACACAAAGGCTGCTACCAAGTGTTGTTGTATTTCAGTTCCTTTCATAGGCCTCCG AGGTGGCCATTGACTATTTGGGGTATATATGTCATATTTATTTTATCTAGAGTAGCTGGGGCAGCCATTTTCAGGTGTAAATGGCAGAGG ACTCTTCAGCCTGTCAAGCTGCCAGCTTATCTACGGGTTAAAAAGTGCTGCATTGGAAAGTAGGGGGTCATGCCTCAAAATGTAAGTAAG TGCCCACCTTCTAGGAAGCCTGAGGTTTATTTCAGGGATTGCCGTCTGCCCCCCGCCCCCCTTCTCTTTTTTTCTTCTCTGTTTCTATTC TTTTATGGCAGTGGTGGAGTGAGGCAGGGATTTTTTTTTTTTTTTTTCGTGTTTTTGACATTCCTTGAATCTGTTTTTTATTCCCCTTCC ACAGAACAGGCCTGGGACTTTCCAACACCCTGCTAAGGAAGTTCTGTGTCCAAGTCCCACCCAGGCTGGGTTGTCCCCACCTCCTCCAGC CCACACAGCCCAGGCAGCATCCGGGCCAGTGCCCTGCATGACAGAGGGTCTTTGTTGTGTAATGTTTGTTCCCAAGTTGCATTTTCTAAC CGAATCAGTGTGTTTTCATGAAACTGAGTGTTTCTGTGGACCAGTAGTTCCTCTGTTGTCTTCAGTGGTCTTCCTGTGTGGCTCAAGGGT TCTCTGTGAGAGTCTGGATTTTCATTTCTGGAATGGCTGGCCCCATCCCACTTTTCTGTATCATGGGGACACATATAAAGCAGTGTTTAA TAGAGCAGTTTAAGAAGTTGCTTGCATCTGTTGGTTCACCATGGCTCATCTGGGGACCATTTTGGATTCATGTTTCATGGCTTGTGACTG TCCCCAAGCCCACTCCAAACAAAGTGTAAGGATCAGAGTTCTGTCAAGGAGCAGCAGTTCTGCTCTCCCCATCATCTTTGTGCAAGGCCC CTCGGGGGGCACTTTAATAAAAGAATTTGAAATGGGTTGACTGGCCATTCTCATGCTGTGCTCCCTGTCTCTTCTCTTCTCTAAAGAATC ATGTCCCAGCTCCTCAAGGTCCCTCTATGGTTCCACATCTGAGTGTTCGCCACAAGAGCAGCAGCAGCAGGCACAGTGCATGCCATATCT ACCTGCTGCTTCTCTGCTGGGAGGAATGGCCAAGTAGATTATAAAACTCACTTCTGTCTCTTAGGCAGACTTGTACGGCCACAAAATTAC CTAGTCTTCTTCCTGCTGAGCTACTGAGGTATTGCCACCATTTTGACAACTTTGAGTAATTAAAACACTCTTCTGACCCAAAAAGGAAAA AAGGTCACTGACGTGACCCCCCCAGCATGCTAGAGAGCTAATTCCAGTTCTCATATTTGTTTGAATTTCTTCCCAGAGGAGAGGATAGGA ACCTCTCCTCCAGGGCAGTAAATCACCTGCATTTCTGGAGTTGTCGGTATTGTATTCGAAAAGGCCTGGAGCCCCTCCTGCTCAGGAAAG AACTCATTCCAGGGTGTGGAGACAGTGCCGTCTGGCAGGTGAAATACTGTGGGAATTCACGCCACCAGGTGTTTGTGCAAGTGTTGGCCT GGGAAGAATGGGACTTCGGCCTTGTCAGGAGTTGTCTTCATCTGCAGCACGTTTCTTCCTCCTGCAGTAGATCTTAGCTACCCCAGATAT CTCTATGGAGAGAAGTTTGTGGAAAATGCTTTGCTTCGTGGCAGAGTCTGATGCTGTAGGAAAACCTTCGGGCATGTGACAGCAGTGTGG TCCACTCCCTGTTCTGCCCTGGCACTCAGAGTCATGTGTAAGTAGGAAACCTGAGCAAGTCTTCCGTGGAGGACCCTGAGCTGCCGTCTT TGGGATCCTTCCTGTGTCCCCACCGTCTTTCATTTATTTGCTTTCCTGGGCCTCTATCTGGGCCCTACCTTGAGCTTCTCCAGTTTTATT CAAGCCACCAGAGTAAGAATTTGGGTGTAGATGTCACAACTACCTTCTACTCAATTCACCAATTCATTTACTGCTATGGCACGTCTCAGG AATAACTCTAGAAACCTCTAAATCGAAATATTATAAAATCTTGAGCACTTAGTCCTGCTGGTTTTAGTTAGAAAGGCATCCAGGAATTGT TTTCCTACGCCCCCTTGAGTGGAAAGATCTTAGTTAGAAGATAAAGTCAAGTTTGTGTTCAGGGGATGGGAGGAAGACTATAAATAAGAT GAAGAAATCAAAAGTAGGAAACATGATGTAAACGAAGCATGGCAGATCTGTCCAGCACTGATATTGCTCTATAAATTGAGCTTACTCAGT TTTGGCCTTATTTTTTTACCCAGGCCCCATGTCACCCAGTCCTAAAACAGTAACCGTGTCTACATAACGGGTTGGCCCCTGGTGCATCCC TGGAAAAGTCAAAGGACGCACACTTCGAAATTCTGCAGAACGTATTTATACATGGTTCAGAAATCTTGCGTATCTGACTTATAGCCAAAT CTGCTTGCTCGAATAGCCTCAGAGGAAGTCTTGTTTAATAAAAACCTTTTGATTTCCTAGTCAAGTCTTTATGGTTGTCTCGAGGGGTGT GTGGCTACTTTAATGAAAGGCTTTCCTGCTCTAAATCTCTTTGCTGGGCTGGGCCTCTTCAGACTATCTGGTGAAACTCCTTTCCTTAGA ACAAACTCAGTCCGTCCATGCTCTGTGGCATTTTGCTAGATGATAACCAAAGCCTTATTCCTGTAGCCAGTGTCAGCAGTCAGAGAGGTG GAGGGTGTGTTCTGCTGTGGTTATGCATACCTATCTGCTGTTCTTGAGGTGTAAAAGGAAAGGTGAAAATCGGGCCAGGCCAAGTACTCA GCTGTCTTAATAGGATGAAGCCTTAAGCAGTGGAAATTTCAGTTATTTTCCACAGTATTCCATTTTGGAGGATTTGGGGTGTTTACTTTT TAAATTCTTGAACAACTTAACCTCCATGAGGCTTTGTGAAGTCAGCTGTGACCACCCTCCTCTTACTGTGTTCTCAGTATTCATTCACTT CCAGGGAAGAATGACAGCCACAGGGAGATGGTGGTGGGCAAGAATGAGAGTCCCAGGATCCAGATTTAGCCTCAGATCTTCCCCATTCAG GAAGGGTTTTCCATTTAACAAGAGCACTAGTATGAAAACATTAGGGACAAATCTCCCATGTCTTTGAAATTCGGATTCTCCTCTTGAGAT CCCCTTCCTCACCTGCCAATCAACTTTATAAGGCCACAAGTGGTCACTGGTTTTCCTTCCACAGGTTTGAGGTTCTCAGCTTTCCTTAAG CGACCCAGCAGCTCCGCTGTTTTCAGAGTGAATATGTTAAGCTTTGATGAGATTCTATTTTCAGTAAGTTAGTGCTTCTGGGACACTTGG AGAAAGCTGTGAGAGTCATTGTCTACGCAAAGAACAACGAAGCTGATCCTAAAAGTGATCCAATCTAAGAAAATGGTAAAACGAGCTCTG GCCACAGCACAGAATTTTATGTGAGGAACTCAGATTTTTGAAGACTTAACAATTGCAGAGAAAGGTTGCAGCCTGCACACCATAGCCCAC CTCTCTGAGCAGACTTTGGTTTTGTGTGGTGACGTGGCACATGTTTGTACACTGGGATTTTTCAAAGGACGCTACGCGAGCAGACTGACT TGCCTCTTCTGTGAGCACTGTGGCTTTTGTCAGATGGAGTGCCGGTCTGCAGAGGACTGCTCTTTCGAATCCACAGTGTTATCTGTGTAA ATAGCTTTAATTTTTCTTCTGTGTCTTAGGTGAAGTTTTGTTCATGTAGCAACCAGGTAGACAGTGACCAAATAAGGCTGTAAATGTGCT GTAGTTTTCTACTGTGATGTACTTGAAGGAGAACCTGTGTCCTCTACTTTTCTGATCTCCCACAAGTATTTTGTGTTTGTTTCCTGAGTC CTGAGGTTATTATTTTACTCCTGTTTTGCCCCCAGTTTTCTTTGTTTTTTTTCTGGAGACCCAGGGAGGCCCATGGTGGAGATCATTTGT AAGGAATGGATCATGGTCTGGGTTTCCAAAACTACCCTAGTACAGTGAATGAGAGAAATCTGCCTGGAAATTGTTTCAGAACCATGTACC TTTATGCTTTGTGATTGTGAAACATTGACTTTTTTGTAACCCCAAAATGAAAACTGTTTAGTAAAGGGGATCTATTTTGTGTGTTTTGAA ACTTAGGTGCAATGTCCCCTGGAAAAAGCTAAAGAAATGTATATGTTCAATGACATTTTAAAATAAAATATTATATATATGTATATACGA >97228_97228_1_USP15-PPM1H_USP15_chr12_62696701_ENST00000280377_PPM1H_chr12_63114069_ENST00000228705_length(amino acids)=312AA_BP=116 MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI LLPTEGWNKLVSWYTLMEGQEPIARKAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARV MATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQ -------------------------------------------------------------- >97228_97228_2_USP15-PPM1H_USP15_chr12_62696701_ENST00000312635_PPM1H_chr12_63114069_ENST00000228705_length(transcript)=5464nt_BP=366nt TACCGCTAGTGGAAGAAGATGGCGGAAGGCGGAGCGGCGGATCTGGACACCCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTC CGGAAAGGGGACACCTGGTACCTAGTCGATAGTCGCTGGTTCAAACAGTGGAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAG ATGGGAGATCAAAATGTGTATCCTGGACCCATTGATAACTCTGGACTTCTCAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATT GATGAATTGGATTACATACTGTTGCCAACTGAAGGTTGGAATAAACTTGTCAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCA CGAAAGGCATTCATGCAGCCTCACTTGCTGGGAAATGAGTTCACACATTTGGAGTTTCCAAGGAGAGTACAGAGAAAGGAGCTTGGAAAG AAGATGCTCTACAGGGACTTTAATATGACAGGCTGGGCATACAAAACCATTGAGGATGAGGACTTGAAGTTCCCCCTTATATATGGAGAA GGCAAGAAGGCCCGGGTAATGGCAACTATTGGAGTGACCAGGGGACTTGGGGACCATGACCTGAAGGTGCATGACTCCAACATCTACATT AAACCATTCCTGTCTTCAGCTCCAGAGGTAAGAATCTACGATCTTTCAAAATATGATCATGGATCAGATGATGTGCTGATCTTGGCCACT GATGGACTCTGGGACGTTTTATCAAATGAAGAAGTAGCAGAAGCAATCACTCAGTTTCTTCCTAACTGTGATCCAGATGATCCTCACAGG TACACACTGGCAGCTCAGGACCTGGTGATGCGTGCCCGGGGTGTGCTGAAGGACAGAGGATGGCGGATATCTAATGACCGACTGGGCTCA GGAGACGACATTTCTGTATATGTCATTCCTTTAATACATGGAAACAAGCTGTCATGAAAATGGCCCAGGGGATTGGGAGGACAGAGGGGA AGAAAGCTGGGATGCCTCTTGGCAGGACGGAACTGGGAAGTGCCCCAGCTGAGTTCCAAGTGATGCAGTCTCTTCCCAGCCCAAGCGGGG AGTTCATGGCCAAAAGACTATGCTTCAAGATGACCCTTTGGTTTCCATTTCTTCTTTAGTAACAGGTCAACTCAACAAGAGCAAAACACA AAGGCTGCTACCAAGTGTTGTTGTATTTCAGTTCCTTTCATAGGCCTCCGAGGTGGCCATTGACTATTTGGGGTATATATGTCATATTTA TTTTATCTAGAGTAGCTGGGGCAGCCATTTTCAGGTGTAAATGGCAGAGGACTCTTCAGCCTGTCAAGCTGCCAGCTTATCTACGGGTTA AAAAGTGCTGCATTGGAAAGTAGGGGGTCATGCCTCAAAATGTAAGTAAGTGCCCACCTTCTAGGAAGCCTGAGGTTTATTTCAGGGATT GCCGTCTGCCCCCCGCCCCCCTTCTCTTTTTTTCTTCTCTGTTTCTATTCTTTTATGGCAGTGGTGGAGTGAGGCAGGGATTTTTTTTTT TTTTTTTCGTGTTTTTGACATTCCTTGAATCTGTTTTTTATTCCCCTTCCACAGAACAGGCCTGGGACTTTCCAACACCCTGCTAAGGAA GTTCTGTGTCCAAGTCCCACCCAGGCTGGGTTGTCCCCACCTCCTCCAGCCCACACAGCCCAGGCAGCATCCGGGCCAGTGCCCTGCATG ACAGAGGGTCTTTGTTGTGTAATGTTTGTTCCCAAGTTGCATTTTCTAACCGAATCAGTGTGTTTTCATGAAACTGAGTGTTTCTGTGGA CCAGTAGTTCCTCTGTTGTCTTCAGTGGTCTTCCTGTGTGGCTCAAGGGTTCTCTGTGAGAGTCTGGATTTTCATTTCTGGAATGGCTGG CCCCATCCCACTTTTCTGTATCATGGGGACACATATAAAGCAGTGTTTAATAGAGCAGTTTAAGAAGTTGCTTGCATCTGTTGGTTCACC ATGGCTCATCTGGGGACCATTTTGGATTCATGTTTCATGGCTTGTGACTGTCCCCAAGCCCACTCCAAACAAAGTGTAAGGATCAGAGTT CTGTCAAGGAGCAGCAGTTCTGCTCTCCCCATCATCTTTGTGCAAGGCCCCTCGGGGGGCACTTTAATAAAAGAATTTGAAATGGGTTGA CTGGCCATTCTCATGCTGTGCTCCCTGTCTCTTCTCTTCTCTAAAGAATCATGTCCCAGCTCCTCAAGGTCCCTCTATGGTTCCACATCT GAGTGTTCGCCACAAGAGCAGCAGCAGCAGGCACAGTGCATGCCATATCTACCTGCTGCTTCTCTGCTGGGAGGAATGGCCAAGTAGATT ATAAAACTCACTTCTGTCTCTTAGGCAGACTTGTACGGCCACAAAATTACCTAGTCTTCTTCCTGCTGAGCTACTGAGGTATTGCCACCA TTTTGACAACTTTGAGTAATTAAAACACTCTTCTGACCCAAAAAGGAAAAAAGGTCACTGACGTGACCCCCCCAGCATGCTAGAGAGCTA ATTCCAGTTCTCATATTTGTTTGAATTTCTTCCCAGAGGAGAGGATAGGAACCTCTCCTCCAGGGCAGTAAATCACCTGCATTTCTGGAG TTGTCGGTATTGTATTCGAAAAGGCCTGGAGCCCCTCCTGCTCAGGAAAGAACTCATTCCAGGGTGTGGAGACAGTGCCGTCTGGCAGGT GAAATACTGTGGGAATTCACGCCACCAGGTGTTTGTGCAAGTGTTGGCCTGGGAAGAATGGGACTTCGGCCTTGTCAGGAGTTGTCTTCA TCTGCAGCACGTTTCTTCCTCCTGCAGTAGATCTTAGCTACCCCAGATATCTCTATGGAGAGAAGTTTGTGGAAAATGCTTTGCTTCGTG GCAGAGTCTGATGCTGTAGGAAAACCTTCGGGCATGTGACAGCAGTGTGGTCCACTCCCTGTTCTGCCCTGGCACTCAGAGTCATGTGTA AGTAGGAAACCTGAGCAAGTCTTCCGTGGAGGACCCTGAGCTGCCGTCTTTGGGATCCTTCCTGTGTCCCCACCGTCTTTCATTTATTTG CTTTCCTGGGCCTCTATCTGGGCCCTACCTTGAGCTTCTCCAGTTTTATTCAAGCCACCAGAGTAAGAATTTGGGTGTAGATGTCACAAC TACCTTCTACTCAATTCACCAATTCATTTACTGCTATGGCACGTCTCAGGAATAACTCTAGAAACCTCTAAATCGAAATATTATAAAATC TTGAGCACTTAGTCCTGCTGGTTTTAGTTAGAAAGGCATCCAGGAATTGTTTTCCTACGCCCCCTTGAGTGGAAAGATCTTAGTTAGAAG ATAAAGTCAAGTTTGTGTTCAGGGGATGGGAGGAAGACTATAAATAAGATGAAGAAATCAAAAGTAGGAAACATGATGTAAACGAAGCAT GGCAGATCTGTCCAGCACTGATATTGCTCTATAAATTGAGCTTACTCAGTTTTGGCCTTATTTTTTTACCCAGGCCCCATGTCACCCAGT CCTAAAACAGTAACCGTGTCTACATAACGGGTTGGCCCCTGGTGCATCCCTGGAAAAGTCAAAGGACGCACACTTCGAAATTCTGCAGAA CGTATTTATACATGGTTCAGAAATCTTGCGTATCTGACTTATAGCCAAATCTGCTTGCTCGAATAGCCTCAGAGGAAGTCTTGTTTAATA AAAACCTTTTGATTTCCTAGTCAAGTCTTTATGGTTGTCTCGAGGGGTGTGTGGCTACTTTAATGAAAGGCTTTCCTGCTCTAAATCTCT TTGCTGGGCTGGGCCTCTTCAGACTATCTGGTGAAACTCCTTTCCTTAGAACAAACTCAGTCCGTCCATGCTCTGTGGCATTTTGCTAGA TGATAACCAAAGCCTTATTCCTGTAGCCAGTGTCAGCAGTCAGAGAGGTGGAGGGTGTGTTCTGCTGTGGTTATGCATACCTATCTGCTG TTCTTGAGGTGTAAAAGGAAAGGTGAAAATCGGGCCAGGCCAAGTACTCAGCTGTCTTAATAGGATGAAGCCTTAAGCAGTGGAAATTTC AGTTATTTTCCACAGTATTCCATTTTGGAGGATTTGGGGTGTTTACTTTTTAAATTCTTGAACAACTTAACCTCCATGAGGCTTTGTGAA GTCAGCTGTGACCACCCTCCTCTTACTGTGTTCTCAGTATTCATTCACTTCCAGGGAAGAATGACAGCCACAGGGAGATGGTGGTGGGCA AGAATGAGAGTCCCAGGATCCAGATTTAGCCTCAGATCTTCCCCATTCAGGAAGGGTTTTCCATTTAACAAGAGCACTAGTATGAAAACA TTAGGGACAAATCTCCCATGTCTTTGAAATTCGGATTCTCCTCTTGAGATCCCCTTCCTCACCTGCCAATCAACTTTATAAGGCCACAAG TGGTCACTGGTTTTCCTTCCACAGGTTTGAGGTTCTCAGCTTTCCTTAAGCGACCCAGCAGCTCCGCTGTTTTCAGAGTGAATATGTTAA GCTTTGATGAGATTCTATTTTCAGTAAGTTAGTGCTTCTGGGACACTTGGAGAAAGCTGTGAGAGTCATTGTCTACGCAAAGAACAACGA AGCTGATCCTAAAAGTGATCCAATCTAAGAAAATGGTAAAACGAGCTCTGGCCACAGCACAGAATTTTATGTGAGGAACTCAGATTTTTG AAGACTTAACAATTGCAGAGAAAGGTTGCAGCCTGCACACCATAGCCCACCTCTCTGAGCAGACTTTGGTTTTGTGTGGTGACGTGGCAC ATGTTTGTACACTGGGATTTTTCAAAGGACGCTACGCGAGCAGACTGACTTGCCTCTTCTGTGAGCACTGTGGCTTTTGTCAGATGGAGT GCCGGTCTGCAGAGGACTGCTCTTTCGAATCCACAGTGTTATCTGTGTAAATAGCTTTAATTTTTCTTCTGTGTCTTAGGTGAAGTTTTG TTCATGTAGCAACCAGGTAGACAGTGACCAAATAAGGCTGTAAATGTGCTGTAGTTTTCTACTGTGATGTACTTGAAGGAGAACCTGTGT CCTCTACTTTTCTGATCTCCCACAAGTATTTTGTGTTTGTTTCCTGAGTCCTGAGGTTATTATTTTACTCCTGTTTTGCCCCCAGTTTTC TTTGTTTTTTTTCTGGAGACCCAGGGAGGCCCATGGTGGAGATCATTTGTAAGGAATGGATCATGGTCTGGGTTTCCAAAACTACCCTAG TACAGTGAATGAGAGAAATCTGCCTGGAAATTGTTTCAGAACCATGTACCTTTATGCTTTGTGATTGTGAAACATTGACTTTTTTGTAAC CCCAAAATGAAAACTGTTTAGTAAAGGGGATCTATTTTGTGTGTTTTGAAACTTAGGTGCAATGTCCCCTGGAAAAAGCTAAAGAAATGT >97228_97228_2_USP15-PPM1H_USP15_chr12_62696701_ENST00000312635_PPM1H_chr12_63114069_ENST00000228705_length(amino acids)=312AA_BP=116 MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI LLPTEGWNKLVSWYTLMEGQEPIARKAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARV MATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQ -------------------------------------------------------------- >97228_97228_3_USP15-PPM1H_USP15_chr12_62696701_ENST00000353364_PPM1H_chr12_63114069_ENST00000228705_length(transcript)=5523nt_BP=425nt GTGGGACGCCATTCCCATAATGCTCTGGGGCGTGCCGCCGCCGTCGCTGCCACCTCCCCTACCGCTAGTGGAAGAAGATGGCGGAAGGCG GAGCGGCGGATCTGGACACCCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTCCGGAAAGGGGACACCTGGTACCTAGTCGATA GTCGCTGGTTCAAACAGTGGAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAGATGGGAGATCAAAATGTGTATCCTGGACCCA TTGATAACTCTGGACTTCTCAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATTGATGAATTGGATTACATACTGTTGCCAACTG AAGGTTGGAATAAACTTGTCAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCACGAAAGGCATTCATGCAGCCTCACTTGCTGG GAAATGAGTTCACACATTTGGAGTTTCCAAGGAGAGTACAGAGAAAGGAGCTTGGAAAGAAGATGCTCTACAGGGACTTTAATATGACAG GCTGGGCATACAAAACCATTGAGGATGAGGACTTGAAGTTCCCCCTTATATATGGAGAAGGCAAGAAGGCCCGGGTAATGGCAACTATTG GAGTGACCAGGGGACTTGGGGACCATGACCTGAAGGTGCATGACTCCAACATCTACATTAAACCATTCCTGTCTTCAGCTCCAGAGGTAA GAATCTACGATCTTTCAAAATATGATCATGGATCAGATGATGTGCTGATCTTGGCCACTGATGGACTCTGGGACGTTTTATCAAATGAAG AAGTAGCAGAAGCAATCACTCAGTTTCTTCCTAACTGTGATCCAGATGATCCTCACAGGTACACACTGGCAGCTCAGGACCTGGTGATGC GTGCCCGGGGTGTGCTGAAGGACAGAGGATGGCGGATATCTAATGACCGACTGGGCTCAGGAGACGACATTTCTGTATATGTCATTCCTT TAATACATGGAAACAAGCTGTCATGAAAATGGCCCAGGGGATTGGGAGGACAGAGGGGAAGAAAGCTGGGATGCCTCTTGGCAGGACGGA ACTGGGAAGTGCCCCAGCTGAGTTCCAAGTGATGCAGTCTCTTCCCAGCCCAAGCGGGGAGTTCATGGCCAAAAGACTATGCTTCAAGAT GACCCTTTGGTTTCCATTTCTTCTTTAGTAACAGGTCAACTCAACAAGAGCAAAACACAAAGGCTGCTACCAAGTGTTGTTGTATTTCAG TTCCTTTCATAGGCCTCCGAGGTGGCCATTGACTATTTGGGGTATATATGTCATATTTATTTTATCTAGAGTAGCTGGGGCAGCCATTTT CAGGTGTAAATGGCAGAGGACTCTTCAGCCTGTCAAGCTGCCAGCTTATCTACGGGTTAAAAAGTGCTGCATTGGAAAGTAGGGGGTCAT GCCTCAAAATGTAAGTAAGTGCCCACCTTCTAGGAAGCCTGAGGTTTATTTCAGGGATTGCCGTCTGCCCCCCGCCCCCCTTCTCTTTTT TTCTTCTCTGTTTCTATTCTTTTATGGCAGTGGTGGAGTGAGGCAGGGATTTTTTTTTTTTTTTTTCGTGTTTTTGACATTCCTTGAATC TGTTTTTTATTCCCCTTCCACAGAACAGGCCTGGGACTTTCCAACACCCTGCTAAGGAAGTTCTGTGTCCAAGTCCCACCCAGGCTGGGT TGTCCCCACCTCCTCCAGCCCACACAGCCCAGGCAGCATCCGGGCCAGTGCCCTGCATGACAGAGGGTCTTTGTTGTGTAATGTTTGTTC CCAAGTTGCATTTTCTAACCGAATCAGTGTGTTTTCATGAAACTGAGTGTTTCTGTGGACCAGTAGTTCCTCTGTTGTCTTCAGTGGTCT TCCTGTGTGGCTCAAGGGTTCTCTGTGAGAGTCTGGATTTTCATTTCTGGAATGGCTGGCCCCATCCCACTTTTCTGTATCATGGGGACA CATATAAAGCAGTGTTTAATAGAGCAGTTTAAGAAGTTGCTTGCATCTGTTGGTTCACCATGGCTCATCTGGGGACCATTTTGGATTCAT GTTTCATGGCTTGTGACTGTCCCCAAGCCCACTCCAAACAAAGTGTAAGGATCAGAGTTCTGTCAAGGAGCAGCAGTTCTGCTCTCCCCA TCATCTTTGTGCAAGGCCCCTCGGGGGGCACTTTAATAAAAGAATTTGAAATGGGTTGACTGGCCATTCTCATGCTGTGCTCCCTGTCTC TTCTCTTCTCTAAAGAATCATGTCCCAGCTCCTCAAGGTCCCTCTATGGTTCCACATCTGAGTGTTCGCCACAAGAGCAGCAGCAGCAGG CACAGTGCATGCCATATCTACCTGCTGCTTCTCTGCTGGGAGGAATGGCCAAGTAGATTATAAAACTCACTTCTGTCTCTTAGGCAGACT TGTACGGCCACAAAATTACCTAGTCTTCTTCCTGCTGAGCTACTGAGGTATTGCCACCATTTTGACAACTTTGAGTAATTAAAACACTCT TCTGACCCAAAAAGGAAAAAAGGTCACTGACGTGACCCCCCCAGCATGCTAGAGAGCTAATTCCAGTTCTCATATTTGTTTGAATTTCTT CCCAGAGGAGAGGATAGGAACCTCTCCTCCAGGGCAGTAAATCACCTGCATTTCTGGAGTTGTCGGTATTGTATTCGAAAAGGCCTGGAG CCCCTCCTGCTCAGGAAAGAACTCATTCCAGGGTGTGGAGACAGTGCCGTCTGGCAGGTGAAATACTGTGGGAATTCACGCCACCAGGTG TTTGTGCAAGTGTTGGCCTGGGAAGAATGGGACTTCGGCCTTGTCAGGAGTTGTCTTCATCTGCAGCACGTTTCTTCCTCCTGCAGTAGA TCTTAGCTACCCCAGATATCTCTATGGAGAGAAGTTTGTGGAAAATGCTTTGCTTCGTGGCAGAGTCTGATGCTGTAGGAAAACCTTCGG GCATGTGACAGCAGTGTGGTCCACTCCCTGTTCTGCCCTGGCACTCAGAGTCATGTGTAAGTAGGAAACCTGAGCAAGTCTTCCGTGGAG GACCCTGAGCTGCCGTCTTTGGGATCCTTCCTGTGTCCCCACCGTCTTTCATTTATTTGCTTTCCTGGGCCTCTATCTGGGCCCTACCTT GAGCTTCTCCAGTTTTATTCAAGCCACCAGAGTAAGAATTTGGGTGTAGATGTCACAACTACCTTCTACTCAATTCACCAATTCATTTAC TGCTATGGCACGTCTCAGGAATAACTCTAGAAACCTCTAAATCGAAATATTATAAAATCTTGAGCACTTAGTCCTGCTGGTTTTAGTTAG AAAGGCATCCAGGAATTGTTTTCCTACGCCCCCTTGAGTGGAAAGATCTTAGTTAGAAGATAAAGTCAAGTTTGTGTTCAGGGGATGGGA GGAAGACTATAAATAAGATGAAGAAATCAAAAGTAGGAAACATGATGTAAACGAAGCATGGCAGATCTGTCCAGCACTGATATTGCTCTA TAAATTGAGCTTACTCAGTTTTGGCCTTATTTTTTTACCCAGGCCCCATGTCACCCAGTCCTAAAACAGTAACCGTGTCTACATAACGGG TTGGCCCCTGGTGCATCCCTGGAAAAGTCAAAGGACGCACACTTCGAAATTCTGCAGAACGTATTTATACATGGTTCAGAAATCTTGCGT ATCTGACTTATAGCCAAATCTGCTTGCTCGAATAGCCTCAGAGGAAGTCTTGTTTAATAAAAACCTTTTGATTTCCTAGTCAAGTCTTTA TGGTTGTCTCGAGGGGTGTGTGGCTACTTTAATGAAAGGCTTTCCTGCTCTAAATCTCTTTGCTGGGCTGGGCCTCTTCAGACTATCTGG TGAAACTCCTTTCCTTAGAACAAACTCAGTCCGTCCATGCTCTGTGGCATTTTGCTAGATGATAACCAAAGCCTTATTCCTGTAGCCAGT GTCAGCAGTCAGAGAGGTGGAGGGTGTGTTCTGCTGTGGTTATGCATACCTATCTGCTGTTCTTGAGGTGTAAAAGGAAAGGTGAAAATC GGGCCAGGCCAAGTACTCAGCTGTCTTAATAGGATGAAGCCTTAAGCAGTGGAAATTTCAGTTATTTTCCACAGTATTCCATTTTGGAGG ATTTGGGGTGTTTACTTTTTAAATTCTTGAACAACTTAACCTCCATGAGGCTTTGTGAAGTCAGCTGTGACCACCCTCCTCTTACTGTGT TCTCAGTATTCATTCACTTCCAGGGAAGAATGACAGCCACAGGGAGATGGTGGTGGGCAAGAATGAGAGTCCCAGGATCCAGATTTAGCC TCAGATCTTCCCCATTCAGGAAGGGTTTTCCATTTAACAAGAGCACTAGTATGAAAACATTAGGGACAAATCTCCCATGTCTTTGAAATT CGGATTCTCCTCTTGAGATCCCCTTCCTCACCTGCCAATCAACTTTATAAGGCCACAAGTGGTCACTGGTTTTCCTTCCACAGGTTTGAG GTTCTCAGCTTTCCTTAAGCGACCCAGCAGCTCCGCTGTTTTCAGAGTGAATATGTTAAGCTTTGATGAGATTCTATTTTCAGTAAGTTA GTGCTTCTGGGACACTTGGAGAAAGCTGTGAGAGTCATTGTCTACGCAAAGAACAACGAAGCTGATCCTAAAAGTGATCCAATCTAAGAA AATGGTAAAACGAGCTCTGGCCACAGCACAGAATTTTATGTGAGGAACTCAGATTTTTGAAGACTTAACAATTGCAGAGAAAGGTTGCAG CCTGCACACCATAGCCCACCTCTCTGAGCAGACTTTGGTTTTGTGTGGTGACGTGGCACATGTTTGTACACTGGGATTTTTCAAAGGACG CTACGCGAGCAGACTGACTTGCCTCTTCTGTGAGCACTGTGGCTTTTGTCAGATGGAGTGCCGGTCTGCAGAGGACTGCTCTTTCGAATC CACAGTGTTATCTGTGTAAATAGCTTTAATTTTTCTTCTGTGTCTTAGGTGAAGTTTTGTTCATGTAGCAACCAGGTAGACAGTGACCAA ATAAGGCTGTAAATGTGCTGTAGTTTTCTACTGTGATGTACTTGAAGGAGAACCTGTGTCCTCTACTTTTCTGATCTCCCACAAGTATTT TGTGTTTGTTTCCTGAGTCCTGAGGTTATTATTTTACTCCTGTTTTGCCCCCAGTTTTCTTTGTTTTTTTTCTGGAGACCCAGGGAGGCC CATGGTGGAGATCATTTGTAAGGAATGGATCATGGTCTGGGTTTCCAAAACTACCCTAGTACAGTGAATGAGAGAAATCTGCCTGGAAAT TGTTTCAGAACCATGTACCTTTATGCTTTGTGATTGTGAAACATTGACTTTTTTGTAACCCCAAAATGAAAACTGTTTAGTAAAGGGGAT CTATTTTGTGTGTTTTGAAACTTAGGTGCAATGTCCCCTGGAAAAAGCTAAAGAAATGTATATGTTCAATGACATTTTAAAATAAAATAT >97228_97228_3_USP15-PPM1H_USP15_chr12_62696701_ENST00000353364_PPM1H_chr12_63114069_ENST00000228705_length(amino acids)=312AA_BP=116 MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI LLPTEGWNKLVSWYTLMEGQEPIARKAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARV MATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQ -------------------------------------------------------------- >97228_97228_4_USP15-PPM1H_USP15_chr12_62696701_ENST00000393654_PPM1H_chr12_63114069_ENST00000228705_length(transcript)=5455nt_BP=357nt TGGAAGAAGATGGCGGAAGGCGGAGCGGCGGATCTGGACACCCAGCGGTCTGACATCGCGACGCTGCTCAAAACCTCGCTCCGGAAAGGG GACACCTGGTACCTAGTCGATAGTCGCTGGTTCAAACAGTGGAAAAAATATGTTGGCTTTGACAGTTGGGACAAATACCAGATGGGAGAT CAAAATGTGTATCCTGGACCCATTGATAACTCTGGACTTCTCAAAGATGGTGATGCCCAGTCACTTAAGGAACACCTTATTGATGAATTG GATTACATACTGTTGCCAACTGAAGGTTGGAATAAACTTGTCAGCTGGTACACATTGATGGAAGGTCAAGAGCCAATAGCACGAAAGGCA TTCATGCAGCCTCACTTGCTGGGAAATGAGTTCACACATTTGGAGTTTCCAAGGAGAGTACAGAGAAAGGAGCTTGGAAAGAAGATGCTC TACAGGGACTTTAATATGACAGGCTGGGCATACAAAACCATTGAGGATGAGGACTTGAAGTTCCCCCTTATATATGGAGAAGGCAAGAAG GCCCGGGTAATGGCAACTATTGGAGTGACCAGGGGACTTGGGGACCATGACCTGAAGGTGCATGACTCCAACATCTACATTAAACCATTC CTGTCTTCAGCTCCAGAGGTAAGAATCTACGATCTTTCAAAATATGATCATGGATCAGATGATGTGCTGATCTTGGCCACTGATGGACTC TGGGACGTTTTATCAAATGAAGAAGTAGCAGAAGCAATCACTCAGTTTCTTCCTAACTGTGATCCAGATGATCCTCACAGGTACACACTG GCAGCTCAGGACCTGGTGATGCGTGCCCGGGGTGTGCTGAAGGACAGAGGATGGCGGATATCTAATGACCGACTGGGCTCAGGAGACGAC ATTTCTGTATATGTCATTCCTTTAATACATGGAAACAAGCTGTCATGAAAATGGCCCAGGGGATTGGGAGGACAGAGGGGAAGAAAGCTG GGATGCCTCTTGGCAGGACGGAACTGGGAAGTGCCCCAGCTGAGTTCCAAGTGATGCAGTCTCTTCCCAGCCCAAGCGGGGAGTTCATGG CCAAAAGACTATGCTTCAAGATGACCCTTTGGTTTCCATTTCTTCTTTAGTAACAGGTCAACTCAACAAGAGCAAAACACAAAGGCTGCT ACCAAGTGTTGTTGTATTTCAGTTCCTTTCATAGGCCTCCGAGGTGGCCATTGACTATTTGGGGTATATATGTCATATTTATTTTATCTA GAGTAGCTGGGGCAGCCATTTTCAGGTGTAAATGGCAGAGGACTCTTCAGCCTGTCAAGCTGCCAGCTTATCTACGGGTTAAAAAGTGCT GCATTGGAAAGTAGGGGGTCATGCCTCAAAATGTAAGTAAGTGCCCACCTTCTAGGAAGCCTGAGGTTTATTTCAGGGATTGCCGTCTGC CCCCCGCCCCCCTTCTCTTTTTTTCTTCTCTGTTTCTATTCTTTTATGGCAGTGGTGGAGTGAGGCAGGGATTTTTTTTTTTTTTTTTCG TGTTTTTGACATTCCTTGAATCTGTTTTTTATTCCCCTTCCACAGAACAGGCCTGGGACTTTCCAACACCCTGCTAAGGAAGTTCTGTGT CCAAGTCCCACCCAGGCTGGGTTGTCCCCACCTCCTCCAGCCCACACAGCCCAGGCAGCATCCGGGCCAGTGCCCTGCATGACAGAGGGT CTTTGTTGTGTAATGTTTGTTCCCAAGTTGCATTTTCTAACCGAATCAGTGTGTTTTCATGAAACTGAGTGTTTCTGTGGACCAGTAGTT CCTCTGTTGTCTTCAGTGGTCTTCCTGTGTGGCTCAAGGGTTCTCTGTGAGAGTCTGGATTTTCATTTCTGGAATGGCTGGCCCCATCCC ACTTTTCTGTATCATGGGGACACATATAAAGCAGTGTTTAATAGAGCAGTTTAAGAAGTTGCTTGCATCTGTTGGTTCACCATGGCTCAT CTGGGGACCATTTTGGATTCATGTTTCATGGCTTGTGACTGTCCCCAAGCCCACTCCAAACAAAGTGTAAGGATCAGAGTTCTGTCAAGG AGCAGCAGTTCTGCTCTCCCCATCATCTTTGTGCAAGGCCCCTCGGGGGGCACTTTAATAAAAGAATTTGAAATGGGTTGACTGGCCATT CTCATGCTGTGCTCCCTGTCTCTTCTCTTCTCTAAAGAATCATGTCCCAGCTCCTCAAGGTCCCTCTATGGTTCCACATCTGAGTGTTCG CCACAAGAGCAGCAGCAGCAGGCACAGTGCATGCCATATCTACCTGCTGCTTCTCTGCTGGGAGGAATGGCCAAGTAGATTATAAAACTC ACTTCTGTCTCTTAGGCAGACTTGTACGGCCACAAAATTACCTAGTCTTCTTCCTGCTGAGCTACTGAGGTATTGCCACCATTTTGACAA CTTTGAGTAATTAAAACACTCTTCTGACCCAAAAAGGAAAAAAGGTCACTGACGTGACCCCCCCAGCATGCTAGAGAGCTAATTCCAGTT CTCATATTTGTTTGAATTTCTTCCCAGAGGAGAGGATAGGAACCTCTCCTCCAGGGCAGTAAATCACCTGCATTTCTGGAGTTGTCGGTA TTGTATTCGAAAAGGCCTGGAGCCCCTCCTGCTCAGGAAAGAACTCATTCCAGGGTGTGGAGACAGTGCCGTCTGGCAGGTGAAATACTG TGGGAATTCACGCCACCAGGTGTTTGTGCAAGTGTTGGCCTGGGAAGAATGGGACTTCGGCCTTGTCAGGAGTTGTCTTCATCTGCAGCA CGTTTCTTCCTCCTGCAGTAGATCTTAGCTACCCCAGATATCTCTATGGAGAGAAGTTTGTGGAAAATGCTTTGCTTCGTGGCAGAGTCT GATGCTGTAGGAAAACCTTCGGGCATGTGACAGCAGTGTGGTCCACTCCCTGTTCTGCCCTGGCACTCAGAGTCATGTGTAAGTAGGAAA CCTGAGCAAGTCTTCCGTGGAGGACCCTGAGCTGCCGTCTTTGGGATCCTTCCTGTGTCCCCACCGTCTTTCATTTATTTGCTTTCCTGG GCCTCTATCTGGGCCCTACCTTGAGCTTCTCCAGTTTTATTCAAGCCACCAGAGTAAGAATTTGGGTGTAGATGTCACAACTACCTTCTA CTCAATTCACCAATTCATTTACTGCTATGGCACGTCTCAGGAATAACTCTAGAAACCTCTAAATCGAAATATTATAAAATCTTGAGCACT TAGTCCTGCTGGTTTTAGTTAGAAAGGCATCCAGGAATTGTTTTCCTACGCCCCCTTGAGTGGAAAGATCTTAGTTAGAAGATAAAGTCA AGTTTGTGTTCAGGGGATGGGAGGAAGACTATAAATAAGATGAAGAAATCAAAAGTAGGAAACATGATGTAAACGAAGCATGGCAGATCT GTCCAGCACTGATATTGCTCTATAAATTGAGCTTACTCAGTTTTGGCCTTATTTTTTTACCCAGGCCCCATGTCACCCAGTCCTAAAACA GTAACCGTGTCTACATAACGGGTTGGCCCCTGGTGCATCCCTGGAAAAGTCAAAGGACGCACACTTCGAAATTCTGCAGAACGTATTTAT ACATGGTTCAGAAATCTTGCGTATCTGACTTATAGCCAAATCTGCTTGCTCGAATAGCCTCAGAGGAAGTCTTGTTTAATAAAAACCTTT TGATTTCCTAGTCAAGTCTTTATGGTTGTCTCGAGGGGTGTGTGGCTACTTTAATGAAAGGCTTTCCTGCTCTAAATCTCTTTGCTGGGC TGGGCCTCTTCAGACTATCTGGTGAAACTCCTTTCCTTAGAACAAACTCAGTCCGTCCATGCTCTGTGGCATTTTGCTAGATGATAACCA AAGCCTTATTCCTGTAGCCAGTGTCAGCAGTCAGAGAGGTGGAGGGTGTGTTCTGCTGTGGTTATGCATACCTATCTGCTGTTCTTGAGG TGTAAAAGGAAAGGTGAAAATCGGGCCAGGCCAAGTACTCAGCTGTCTTAATAGGATGAAGCCTTAAGCAGTGGAAATTTCAGTTATTTT CCACAGTATTCCATTTTGGAGGATTTGGGGTGTTTACTTTTTAAATTCTTGAACAACTTAACCTCCATGAGGCTTTGTGAAGTCAGCTGT GACCACCCTCCTCTTACTGTGTTCTCAGTATTCATTCACTTCCAGGGAAGAATGACAGCCACAGGGAGATGGTGGTGGGCAAGAATGAGA GTCCCAGGATCCAGATTTAGCCTCAGATCTTCCCCATTCAGGAAGGGTTTTCCATTTAACAAGAGCACTAGTATGAAAACATTAGGGACA AATCTCCCATGTCTTTGAAATTCGGATTCTCCTCTTGAGATCCCCTTCCTCACCTGCCAATCAACTTTATAAGGCCACAAGTGGTCACTG GTTTTCCTTCCACAGGTTTGAGGTTCTCAGCTTTCCTTAAGCGACCCAGCAGCTCCGCTGTTTTCAGAGTGAATATGTTAAGCTTTGATG AGATTCTATTTTCAGTAAGTTAGTGCTTCTGGGACACTTGGAGAAAGCTGTGAGAGTCATTGTCTACGCAAAGAACAACGAAGCTGATCC TAAAAGTGATCCAATCTAAGAAAATGGTAAAACGAGCTCTGGCCACAGCACAGAATTTTATGTGAGGAACTCAGATTTTTGAAGACTTAA CAATTGCAGAGAAAGGTTGCAGCCTGCACACCATAGCCCACCTCTCTGAGCAGACTTTGGTTTTGTGTGGTGACGTGGCACATGTTTGTA CACTGGGATTTTTCAAAGGACGCTACGCGAGCAGACTGACTTGCCTCTTCTGTGAGCACTGTGGCTTTTGTCAGATGGAGTGCCGGTCTG CAGAGGACTGCTCTTTCGAATCCACAGTGTTATCTGTGTAAATAGCTTTAATTTTTCTTCTGTGTCTTAGGTGAAGTTTTGTTCATGTAG CAACCAGGTAGACAGTGACCAAATAAGGCTGTAAATGTGCTGTAGTTTTCTACTGTGATGTACTTGAAGGAGAACCTGTGTCCTCTACTT TTCTGATCTCCCACAAGTATTTTGTGTTTGTTTCCTGAGTCCTGAGGTTATTATTTTACTCCTGTTTTGCCCCCAGTTTTCTTTGTTTTT TTTCTGGAGACCCAGGGAGGCCCATGGTGGAGATCATTTGTAAGGAATGGATCATGGTCTGGGTTTCCAAAACTACCCTAGTACAGTGAA TGAGAGAAATCTGCCTGGAAATTGTTTCAGAACCATGTACCTTTATGCTTTGTGATTGTGAAACATTGACTTTTTTGTAACCCCAAAATG AAAACTGTTTAGTAAAGGGGATCTATTTTGTGTGTTTTGAAACTTAGGTGCAATGTCCCCTGGAAAAAGCTAAAGAAATGTATATGTTCA >97228_97228_4_USP15-PPM1H_USP15_chr12_62696701_ENST00000393654_PPM1H_chr12_63114069_ENST00000228705_length(amino acids)=312AA_BP=116 MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYI LLPTEGWNKLVSWYTLMEGQEPIARKAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARV MATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for USP15-PPM1H |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for USP15-PPM1H |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for USP15-PPM1H |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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