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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP25-CYYR1 (FusionGDB2 ID:97295)

Fusion Gene Summary for USP25-CYYR1

check button Fusion gene summary
Fusion gene informationFusion gene name: USP25-CYYR1
Fusion gene ID: 97295
HgeneTgene
Gene symbol

USP25

CYYR1

Gene ID

29761

116159

Gene nameubiquitin specific peptidase 25cysteine and tyrosine rich 1
SynonymsUSP21C21orf95
Cytomap

21q21.1

21q21.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 25USP on chromosome 21deubiquitinating enzyme 25ubiquitin thioesterase 25ubiquitin thiolesterase 25ubiquitin-specific processing protease 25cysteine and tyrosine-rich protein 1cysteine and tyrosine-rich protein 1 isoform 1,2,2bis,3,4cysteine and tyrosine-rich protein 1 isoform 1,2,3,4bcysteine and tyrosine-rich protein 1 isoform 1,2,3bcysteine and tyrosine-rich protein 1 isoform 1,2,4cys
Modification date2020031320200313
UniProtAcc.

Q96J86

Ensembl transtripts involved in fusion geneENST00000285679, ENST00000285681, 
ENST00000400183, ENST00000351097, 
ENST00000547201, 		ENST00000435845, 
ENST00000400043, ENST00000299340, 
Fusion gene scores* DoF score13 X 10 X 9=11704 X 4 X 3=48
# samples 135
** MAII scorelog2(13/1170*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: USP25 [Title/Abstract] AND CYYR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP25(17191165)-CYYR1(27840950), # samples:2
USP25(17191165)-CYYR1(27840953), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP25

GO:0016579

protein deubiquitination

22590560


check buttonFusion gene breakpoints across USP25 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CYYR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DS-A0VL-01AUSP25chr21

17191165

+CYYR1chr21

27840950

-
ChimerDB4CESCTCGA-DS-A0VL-01AUSP25chr21

17191165

-CYYR1chr21

27840953

-
ChimerDB4CESCTCGA-DS-A0VL-01AUSP25chr21

17191165

+CYYR1chr21

27840953

-


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Fusion Gene ORF analysis for USP25-CYYR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000285679ENST00000435845USP25chr21

17191165

+CYYR1chr21

27840950

-
5CDS-3UTRENST00000285679ENST00000435845USP25chr21

17191165

+CYYR1chr21

27840953

-
5CDS-3UTRENST00000285681ENST00000435845USP25chr21

17191165

+CYYR1chr21

27840950

-
5CDS-3UTRENST00000285681ENST00000435845USP25chr21

17191165

+CYYR1chr21

27840953

-
5CDS-3UTRENST00000400183ENST00000435845USP25chr21

17191165

+CYYR1chr21

27840950

-
5CDS-3UTRENST00000400183ENST00000435845USP25chr21

17191165

+CYYR1chr21

27840953

-
5CDS-intronENST00000285679ENST00000400043USP25chr21

17191165

+CYYR1chr21

27840950

-
5CDS-intronENST00000285679ENST00000400043USP25chr21

17191165

+CYYR1chr21

27840953

-
5CDS-intronENST00000285681ENST00000400043USP25chr21

17191165

+CYYR1chr21

27840950

-
5CDS-intronENST00000285681ENST00000400043USP25chr21

17191165

+CYYR1chr21

27840953

-
5CDS-intronENST00000400183ENST00000400043USP25chr21

17191165

+CYYR1chr21

27840950

-
5CDS-intronENST00000400183ENST00000400043USP25chr21

17191165

+CYYR1chr21

27840953

-
In-frameENST00000285679ENST00000299340USP25chr21

17191165

+CYYR1chr21

27840950

-
In-frameENST00000285679ENST00000299340USP25chr21

17191165

+CYYR1chr21

27840953

-
In-frameENST00000285681ENST00000299340USP25chr21

17191165

+CYYR1chr21

27840950

-
In-frameENST00000285681ENST00000299340USP25chr21

17191165

+CYYR1chr21

27840953

-
In-frameENST00000400183ENST00000299340USP25chr21

17191165

+CYYR1chr21

27840950

-
In-frameENST00000400183ENST00000299340USP25chr21

17191165

+CYYR1chr21

27840953

-
intron-3CDSENST00000351097ENST00000299340USP25chr21

17191165

+CYYR1chr21

27840950

-
intron-3CDSENST00000351097ENST00000299340USP25chr21

17191165

+CYYR1chr21

27840953

-
intron-3CDSENST00000547201ENST00000299340USP25chr21

17191165

+CYYR1chr21

27840950

-
intron-3CDSENST00000547201ENST00000299340USP25chr21

17191165

+CYYR1chr21

27840953

-
intron-3UTRENST00000351097ENST00000435845USP25chr21

17191165

+CYYR1chr21

27840950

-
intron-3UTRENST00000351097ENST00000435845USP25chr21

17191165

+CYYR1chr21

27840953

-
intron-3UTRENST00000547201ENST00000435845USP25chr21

17191165

+CYYR1chr21

27840950

-
intron-3UTRENST00000547201ENST00000435845USP25chr21

17191165

+CYYR1chr21

27840953

-
intron-intronENST00000351097ENST00000400043USP25chr21

17191165

+CYYR1chr21

27840950

-
intron-intronENST00000351097ENST00000400043USP25chr21

17191165

+CYYR1chr21

27840953

-
intron-intronENST00000547201ENST00000400043USP25chr21

17191165

+CYYR1chr21

27840950

-
intron-intronENST00000547201ENST00000400043USP25chr21

17191165

+CYYR1chr21

27840953

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000285679USP25chr2117191165+ENST00000299340CYYR1chr2127840950-387214491891721510
ENST00000285681USP25chr2117191165+ENST00000299340CYYR1chr2127840950-387214491891721510
ENST00000400183USP25chr2117191165+ENST00000299340CYYR1chr2127840950-37201297371569510
ENST00000285679USP25chr2117191165+ENST00000299340CYYR1chr2127840953-387214491891721510
ENST00000285681USP25chr2117191165+ENST00000299340CYYR1chr2127840953-387214491891721510
ENST00000400183USP25chr2117191165+ENST00000299340CYYR1chr2127840953-37201297371569510

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000285679ENST00000299340USP25chr2117191165+CYYR1chr2127840950-0.0003221570.9996779
ENST00000285681ENST00000299340USP25chr2117191165+CYYR1chr2127840950-0.0003221570.9996779
ENST00000400183ENST00000299340USP25chr2117191165+CYYR1chr2127840950-0.0002938180.9997062
ENST00000285679ENST00000299340USP25chr2117191165+CYYR1chr2127840953-0.0003221570.9996779
ENST00000285681ENST00000299340USP25chr2117191165+CYYR1chr2127840953-0.0003221570.9996779
ENST00000400183ENST00000299340USP25chr2117191165+CYYR1chr2127840953-0.0002938180.9997062

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Fusion Genomic Features for USP25-CYYR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP25-CYYR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:17191165/chr21:27840950)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CYYR1

Q96J86

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP25chr21:17191165chr21:27840950ENST00000285679+1024123_1403601056.0DomainUIM 2
HgeneUSP25chr21:17191165chr21:27840950ENST00000285679+102414_573601056.0DomainNote=UBA-like
HgeneUSP25chr21:17191165chr21:27840950ENST00000285679+102497_1163601056.0DomainUIM 1
HgeneUSP25chr21:17191165chr21:27840950ENST00000285681+1025123_1403601088.0DomainUIM 2
HgeneUSP25chr21:17191165chr21:27840950ENST00000285681+102514_573601088.0DomainNote=UBA-like
HgeneUSP25chr21:17191165chr21:27840950ENST00000285681+102597_1163601088.0DomainUIM 1
HgeneUSP25chr21:17191165chr21:27840950ENST00000400183+1026123_1403601126.0DomainUIM 2
HgeneUSP25chr21:17191165chr21:27840950ENST00000400183+102614_573601126.0DomainNote=UBA-like
HgeneUSP25chr21:17191165chr21:27840950ENST00000400183+102697_1163601126.0DomainUIM 1
HgeneUSP25chr21:17191165chr21:27840953ENST00000285679+1024123_1403601056.0DomainUIM 2
HgeneUSP25chr21:17191165chr21:27840953ENST00000285679+102414_573601056.0DomainNote=UBA-like
HgeneUSP25chr21:17191165chr21:27840953ENST00000285679+102497_1163601056.0DomainUIM 1
HgeneUSP25chr21:17191165chr21:27840953ENST00000285681+1025123_1403601088.0DomainUIM 2
HgeneUSP25chr21:17191165chr21:27840953ENST00000285681+102514_573601088.0DomainNote=UBA-like
HgeneUSP25chr21:17191165chr21:27840953ENST00000285681+102597_1163601088.0DomainUIM 1
HgeneUSP25chr21:17191165chr21:27840953ENST00000400183+1026123_1403601126.0DomainUIM 2
HgeneUSP25chr21:17191165chr21:27840953ENST00000400183+102614_573601126.0DomainNote=UBA-like
HgeneUSP25chr21:17191165chr21:27840953ENST00000400183+102697_1163601126.0DomainUIM 1
HgeneUSP25chr21:17191165chr21:27840950ENST00000285679+102489_953601056.0MotifNote=Required for SUMO paralog-specific binding
HgeneUSP25chr21:17191165chr21:27840950ENST00000285681+102589_953601088.0MotifNote=Required for SUMO paralog-specific binding
HgeneUSP25chr21:17191165chr21:27840950ENST00000400183+102689_953601126.0MotifNote=Required for SUMO paralog-specific binding
HgeneUSP25chr21:17191165chr21:27840953ENST00000285679+102489_953601056.0MotifNote=Required for SUMO paralog-specific binding
HgeneUSP25chr21:17191165chr21:27840953ENST00000285681+102589_953601088.0MotifNote=Required for SUMO paralog-specific binding
HgeneUSP25chr21:17191165chr21:27840953ENST00000400183+102689_953601126.0MotifNote=Required for SUMO paralog-specific binding
TgeneCYYR1chr21:17191165chr21:27840950ENST0000029934024144_149111155.0Compositional biasNote=Poly-Pro
TgeneCYYR1chr21:17191165chr21:27840953ENST0000029934024144_149111155.0Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP25chr21:17191165chr21:27840950ENST00000285679+1024541_5783601056.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17191165chr21:27840950ENST00000285679+1024684_7173601056.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17191165chr21:27840950ENST00000285681+1025541_5783601088.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17191165chr21:27840950ENST00000285681+1025684_7173601088.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17191165chr21:27840950ENST00000400183+1026541_5783601126.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17191165chr21:27840950ENST00000400183+1026684_7173601126.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17191165chr21:27840953ENST00000285679+1024541_5783601056.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17191165chr21:27840953ENST00000285679+1024684_7173601056.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17191165chr21:27840953ENST00000285681+1025541_5783601088.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17191165chr21:27840953ENST00000285681+1025684_7173601088.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17191165chr21:27840953ENST00000400183+1026541_5783601126.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17191165chr21:27840953ENST00000400183+1026684_7173601126.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17191165chr21:27840950ENST00000285679+1024169_6573601056.0DomainNote=USP
HgeneUSP25chr21:17191165chr21:27840950ENST00000285681+1025169_6573601088.0DomainNote=USP
HgeneUSP25chr21:17191165chr21:27840950ENST00000400183+1026169_6573601126.0DomainNote=USP
HgeneUSP25chr21:17191165chr21:27840953ENST00000285679+1024169_6573601056.0DomainNote=USP
HgeneUSP25chr21:17191165chr21:27840953ENST00000285681+1025169_6573601088.0DomainNote=USP
HgeneUSP25chr21:17191165chr21:27840953ENST00000400183+1026169_6573601126.0DomainNote=USP
TgeneCYYR1chr21:17191165chr21:27840950ENST000002993402430_61111155.0Topological domainExtracellular
TgeneCYYR1chr21:17191165chr21:27840950ENST000002993402483_154111155.0Topological domainCytoplasmic
TgeneCYYR1chr21:17191165chr21:27840953ENST000002993402430_61111155.0Topological domainExtracellular
TgeneCYYR1chr21:17191165chr21:27840953ENST000002993402483_154111155.0Topological domainCytoplasmic
TgeneCYYR1chr21:17191165chr21:27840950ENST000002993402462_82111155.0TransmembraneHelical
TgeneCYYR1chr21:17191165chr21:27840953ENST000002993402462_82111155.0TransmembraneHelical


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Fusion Gene Sequence for USP25-CYYR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97295_97295_1_USP25-CYYR1_USP25_chr21_17191165_ENST00000285679_CYYR1_chr21_27840950_ENST00000299340_length(transcript)=3872nt_BP=1449nt
AAGCAGCCCGCGGACCGGCAGCAAAGGAACGTGCGAACGCGTGACGCCGCCCGACTGGCTCGCGCTCTCCCGTGCCCCGGCGTCCTCCGC
CCGCTCATGGCCCGGGCCGCCGCGGACGAGCGGCGCTGAGGCGGGCCGCGTGGAGACGTGAGGCGGCCGCCGTGGCCCTCACAGTCGGCG
TTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGCGGGGGCGCTGTCCTCCCAGGCCGTCCGC
GCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGGCGCCACCGCCGCCGCCGCCGCCGCCGCC
GCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCAGACGTTTTTGAATCAACTGAGAGAAATT
ACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGAATTAGCAGTGGCTTTCCTTACTGCGAAG
AATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGATAGATACATCAGTGTGGGAAGCCAAGCA
GATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTTGAGTTTGGCCGAATCAAACAGGGCATTC
AGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGCAGAGAATAAAGCATGTTTGAAGAGGACA
CCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCCCGTTGGGCTAAAGAATGTTGGCAATACT
TGTTGGTTTAGTGCTGTTATTCAGTCATTATTTAATCTTTTGGAATTTAGAAGATTAGTTCTGAATTACAAGCCTCCATCAAATGCTCAA
GATTTACCCCGAAACCAAAAGGAACATCGGAATTTGCCTTTTATGCGTGAGCTGAGGTATCTATTTGCACTTCTTGTTGGTACCAAAAGG
AAGTATGTTGATCCATCAAGAGCAGTTGAAATTCTTAAGGATGCTTTCAAATCAAATGACTCACAGCAGCAAGATGTGAGTGAGTTTACA
CACAAATTATTAGATTGGTTAGAAGATGCCTTCCAAATGAAAGCTGAAGAGGAGACGGATGAAGAGAAGCCAAAGAACCCCATGGTAGAG
TTGTTCTATGGCAGATTCCTGGCTGTGGGAGTACTTGAAGGTAAAAAATTTGAAAACACTGAAATGTTTGGTCAGTACCCACTTCAGGTC
AATGGGTTCAAAGATCTGCATGAGTGCCTAGAAGCTGCAATGATTGAAGGAGAAATTGAGTCTTTACATTCAGAGAATTCAGGAAAATCA
GGCCAAGAGGACCACCACCCTACGGTCACGACCACGAGATGGAATACTGTGCAGACTTGCCTCCTCCATACTCCCCCACCCCACAGGGTC
CAGCACAGCGTTCTCCACCCCCTCCTTATCCTGGAAACGCAAGGAAATAATCTATCTCCCAGAACAGAACATGTGCCAATGGGCGATCTT
GCCTGGAATAAAATGCCTCTACTCAGAAACAGGCAGGAAAGAATTGCTCCAAGGAATACTTTTTGGGGTCAGATAATGTGTCAGGTGGAA
TATCCCTGCTAGGAGATATAGGATTTCTACTCTGCTCAAAGCTGACCCCATCTGGAGTATTAATGTTTGGTTCTATGGAACCACATTTTA
AGAGATCTGCTGATCCACCTAAGCACATTCAGGGAAGAGTAATGTAATTGACAAAATATCTGATAATCATGTTGTTTAAGGGCTAGGTGA
AGAAAGTTTCAGTATTGATCCTGGAAAAAAAGAAGATCTAAGTAGGATGGGAGAATGATTTGGCCCACACAAGGAAGCAACTTTATTCTA
TATAGCTTTAAAAGTCAGAACTAGAATTGTTCATTCTTTCATTCATCAATAAATGTATTTTGAGTGCCTAAGAGTTTACTATGTGCCTAG
CACTGTTTGAGGTCCTGATGGAAGTTACAGGACGGGTACTCTGGTTTTAGTACAAGAAAGAGCAATGACTAGATTGCTTTGTGAAGCTCT
TGGTAGAGACACGCTCCAGAAGGGATAACAAAATCAAATAGTAGATGGGTTCATTGGGCCTCAGAAGTTCTGCTCGTATTTTAGGTGGGT
GTGAAGTGAATTTCTATATGTCCAGGAGTGAATACAACAGAAAGAGTTGGATCTTATTTATTTAATTAGGGAGTTAAAACAAGACCAAAA
AGACTCAACAGCCGCTTGAAGCCAAGAACTCTTCAATGCCAGCTACTGCCACCTAAAAATCATCTGGCTTTATAGTGGATCAGAATAAAG
GTTATTCTAACTGTGGGGAGAAAAAAAAAATTGTATCAAGTTCCACAGGTAGCAGACACTTCACTTCCAAGTAAAAGATGAGAAATCAAT
TATTCCCACAGGATTTTAGGTCAGGGAGCAAAAATCTCAGAACTTGACCATGAAGATACACAACAGACTCGCAAAAATAAAGTGGGAAAT
GAAGTTCAGATTCCCTTCTGTAGATTTCCTTAAAACTATTATTTTTTTCTTCTTCGTAAAATTTTGATAATCTGTTCTCTTAAAAAAGTT
AATGACACAATTAAGATACTGACATCAAATTGTTGCCTTTTACCAAAATGCAAATTTTATGAAGTGCCTACCTTTATATGTATAAAGCAT
TTAATAAATAATTCTAATGTGCCATATTTTGCTGTGAGTGACCTTAACATTTATATTTTTATATGAATTGTTTCATGTATTTATAAAAAT
TGTATATTGAACATTGGAAATAGATGATTAGATTTTTGTGTCATTTTACAATTAAATCTAAAATGCTTAATCCAATATCATCATCAAAAT
TCAGTGAAATCCCAAAACAGTGCCAAGAATTTTGCTGAATGAAACAATCAAACAAAGCATTTTAAGGTGTAAGTTATAGTACCTGTACTT
GCAGATAAGAAGCTTACTATATCATTATTATAAGTAGCATATATTACTTTCAAATACCTATATTAGAAAGATATTGATCTGACTGAAATA
TAACCTACCTGCCAGTAAGGTCCAAAGGCTGAATTTGTTTTGAATGAGTTCCTTGATCTTTAAGCACTGATGATTTTCTTATATATGAGG
ATGCAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTGAGGGGCTCCCTGACTTACATAAAGTTTTCAGTGCAATTTTAATAGTACATATGC
TTTAATTTATTTTTCTTCTGCGTGTGGTCAGACCCAATTACACTGTGGCTAAGACTCTCAAAGTGCCAGGGTTTCTGTGATGATTCTGAG
AATGCTGAATACAAATATACCTTATATTCTTTAAGGAAAACGGAAAGGAAAGATCAGCAGAAATAGGGTTTTCTCATCTTCACCATCAAT
AAACATTTATTGCGTACCTCCTATATTCTGCAAATTTTCCCCAAATAGAAGCCAGTTCAGTCCACACCATCTCTTCTTTGAGTTGTTTAT
GGCCTCCCTTAAGGCATTTTACAAACCCATAAGCCTACAATAGATGAGTATTTTTACTATTTGTATTAAGTGTCATAATAGCATCAATGT
GCACATTACCAGTATAGACTGTTGGAGTTCACTGATTGTTTTCATAGATGATGCTTCTTGGGGAAAAATAGTATAGGATGTGAAAGTTTT
GAATTACGGTTATTTAAAAACTAACATTTGCTATGGCCAAAGTGTTTACAATAAGCAATAAAGTGAAAGAACCTATTATAACACAGATTA

>97295_97295_1_USP25-CYYR1_USP25_chr21_17191165_ENST00000285679_CYYR1_chr21_27840950_ENST00000299340_length(amino acids)=510AA_BP=418
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLP
RNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFY
GRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEDHHPTVTTTRWNTVQTCLLHTPPPHRVQHS

--------------------------------------------------------------
>97295_97295_2_USP25-CYYR1_USP25_chr21_17191165_ENST00000285679_CYYR1_chr21_27840953_ENST00000299340_length(transcript)=3872nt_BP=1449nt
AAGCAGCCCGCGGACCGGCAGCAAAGGAACGTGCGAACGCGTGACGCCGCCCGACTGGCTCGCGCTCTCCCGTGCCCCGGCGTCCTCCGC
CCGCTCATGGCCCGGGCCGCCGCGGACGAGCGGCGCTGAGGCGGGCCGCGTGGAGACGTGAGGCGGCCGCCGTGGCCCTCACAGTCGGCG
TTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGCGGGGGCGCTGTCCTCCCAGGCCGTCCGC
GCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGGCGCCACCGCCGCCGCCGCCGCCGCCGCC
GCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCAGACGTTTTTGAATCAACTGAGAGAAATT
ACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGAATTAGCAGTGGCTTTCCTTACTGCGAAG
AATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGATAGATACATCAGTGTGGGAAGCCAAGCA
GATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTTGAGTTTGGCCGAATCAAACAGGGCATTC
AGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGCAGAGAATAAAGCATGTTTGAAGAGGACA
CCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCCCGTTGGGCTAAAGAATGTTGGCAATACT
TGTTGGTTTAGTGCTGTTATTCAGTCATTATTTAATCTTTTGGAATTTAGAAGATTAGTTCTGAATTACAAGCCTCCATCAAATGCTCAA
GATTTACCCCGAAACCAAAAGGAACATCGGAATTTGCCTTTTATGCGTGAGCTGAGGTATCTATTTGCACTTCTTGTTGGTACCAAAAGG
AAGTATGTTGATCCATCAAGAGCAGTTGAAATTCTTAAGGATGCTTTCAAATCAAATGACTCACAGCAGCAAGATGTGAGTGAGTTTACA
CACAAATTATTAGATTGGTTAGAAGATGCCTTCCAAATGAAAGCTGAAGAGGAGACGGATGAAGAGAAGCCAAAGAACCCCATGGTAGAG
TTGTTCTATGGCAGATTCCTGGCTGTGGGAGTACTTGAAGGTAAAAAATTTGAAAACACTGAAATGTTTGGTCAGTACCCACTTCAGGTC
AATGGGTTCAAAGATCTGCATGAGTGCCTAGAAGCTGCAATGATTGAAGGAGAAATTGAGTCTTTACATTCAGAGAATTCAGGAAAATCA
GGCCAAGAGGACCACCACCCTACGGTCACGACCACGAGATGGAATACTGTGCAGACTTGCCTCCTCCATACTCCCCCACCCCACAGGGTC
CAGCACAGCGTTCTCCACCCCCTCCTTATCCTGGAAACGCAAGGAAATAATCTATCTCCCAGAACAGAACATGTGCCAATGGGCGATCTT
GCCTGGAATAAAATGCCTCTACTCAGAAACAGGCAGGAAAGAATTGCTCCAAGGAATACTTTTTGGGGTCAGATAATGTGTCAGGTGGAA
TATCCCTGCTAGGAGATATAGGATTTCTACTCTGCTCAAAGCTGACCCCATCTGGAGTATTAATGTTTGGTTCTATGGAACCACATTTTA
AGAGATCTGCTGATCCACCTAAGCACATTCAGGGAAGAGTAATGTAATTGACAAAATATCTGATAATCATGTTGTTTAAGGGCTAGGTGA
AGAAAGTTTCAGTATTGATCCTGGAAAAAAAGAAGATCTAAGTAGGATGGGAGAATGATTTGGCCCACACAAGGAAGCAACTTTATTCTA
TATAGCTTTAAAAGTCAGAACTAGAATTGTTCATTCTTTCATTCATCAATAAATGTATTTTGAGTGCCTAAGAGTTTACTATGTGCCTAG
CACTGTTTGAGGTCCTGATGGAAGTTACAGGACGGGTACTCTGGTTTTAGTACAAGAAAGAGCAATGACTAGATTGCTTTGTGAAGCTCT
TGGTAGAGACACGCTCCAGAAGGGATAACAAAATCAAATAGTAGATGGGTTCATTGGGCCTCAGAAGTTCTGCTCGTATTTTAGGTGGGT
GTGAAGTGAATTTCTATATGTCCAGGAGTGAATACAACAGAAAGAGTTGGATCTTATTTATTTAATTAGGGAGTTAAAACAAGACCAAAA
AGACTCAACAGCCGCTTGAAGCCAAGAACTCTTCAATGCCAGCTACTGCCACCTAAAAATCATCTGGCTTTATAGTGGATCAGAATAAAG
GTTATTCTAACTGTGGGGAGAAAAAAAAAATTGTATCAAGTTCCACAGGTAGCAGACACTTCACTTCCAAGTAAAAGATGAGAAATCAAT
TATTCCCACAGGATTTTAGGTCAGGGAGCAAAAATCTCAGAACTTGACCATGAAGATACACAACAGACTCGCAAAAATAAAGTGGGAAAT
GAAGTTCAGATTCCCTTCTGTAGATTTCCTTAAAACTATTATTTTTTTCTTCTTCGTAAAATTTTGATAATCTGTTCTCTTAAAAAAGTT
AATGACACAATTAAGATACTGACATCAAATTGTTGCCTTTTACCAAAATGCAAATTTTATGAAGTGCCTACCTTTATATGTATAAAGCAT
TTAATAAATAATTCTAATGTGCCATATTTTGCTGTGAGTGACCTTAACATTTATATTTTTATATGAATTGTTTCATGTATTTATAAAAAT
TGTATATTGAACATTGGAAATAGATGATTAGATTTTTGTGTCATTTTACAATTAAATCTAAAATGCTTAATCCAATATCATCATCAAAAT
TCAGTGAAATCCCAAAACAGTGCCAAGAATTTTGCTGAATGAAACAATCAAACAAAGCATTTTAAGGTGTAAGTTATAGTACCTGTACTT
GCAGATAAGAAGCTTACTATATCATTATTATAAGTAGCATATATTACTTTCAAATACCTATATTAGAAAGATATTGATCTGACTGAAATA
TAACCTACCTGCCAGTAAGGTCCAAAGGCTGAATTTGTTTTGAATGAGTTCCTTGATCTTTAAGCACTGATGATTTTCTTATATATGAGG
ATGCAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTGAGGGGCTCCCTGACTTACATAAAGTTTTCAGTGCAATTTTAATAGTACATATGC
TTTAATTTATTTTTCTTCTGCGTGTGGTCAGACCCAATTACACTGTGGCTAAGACTCTCAAAGTGCCAGGGTTTCTGTGATGATTCTGAG
AATGCTGAATACAAATATACCTTATATTCTTTAAGGAAAACGGAAAGGAAAGATCAGCAGAAATAGGGTTTTCTCATCTTCACCATCAAT
AAACATTTATTGCGTACCTCCTATATTCTGCAAATTTTCCCCAAATAGAAGCCAGTTCAGTCCACACCATCTCTTCTTTGAGTTGTTTAT
GGCCTCCCTTAAGGCATTTTACAAACCCATAAGCCTACAATAGATGAGTATTTTTACTATTTGTATTAAGTGTCATAATAGCATCAATGT
GCACATTACCAGTATAGACTGTTGGAGTTCACTGATTGTTTTCATAGATGATGCTTCTTGGGGAAAAATAGTATAGGATGTGAAAGTTTT
GAATTACGGTTATTTAAAAACTAACATTTGCTATGGCCAAAGTGTTTACAATAAGCAATAAAGTGAAAGAACCTATTATAACACAGATTA

>97295_97295_2_USP25-CYYR1_USP25_chr21_17191165_ENST00000285679_CYYR1_chr21_27840953_ENST00000299340_length(amino acids)=510AA_BP=418
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLP
RNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFY
GRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEDHHPTVTTTRWNTVQTCLLHTPPPHRVQHS

--------------------------------------------------------------
>97295_97295_3_USP25-CYYR1_USP25_chr21_17191165_ENST00000285681_CYYR1_chr21_27840950_ENST00000299340_length(transcript)=3872nt_BP=1449nt
AAGCAGCCCGCGGACCGGCAGCAAAGGAACGTGCGAACGCGTGACGCCGCCCGACTGGCTCGCGCTCTCCCGTGCCCCGGCGTCCTCCGC
CCGCTCATGGCCCGGGCCGCCGCGGACGAGCGGCGCTGAGGCGGGCCGCGTGGAGACGTGAGGCGGCCGCCGTGGCCCTCACAGTCGGCG
TTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGCGGGGGCGCTGTCCTCCCAGGCCGTCCGC
GCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGGCGCCACCGCCGCCGCCGCCGCCGCCGCC
GCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCAGACGTTTTTGAATCAACTGAGAGAAATT
ACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGAATTAGCAGTGGCTTTCCTTACTGCGAAG
AATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGATAGATACATCAGTGTGGGAAGCCAAGCA
GATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTTGAGTTTGGCCGAATCAAACAGGGCATTC
AGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGCAGAGAATAAAGCATGTTTGAAGAGGACA
CCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCCCGTTGGGCTAAAGAATGTTGGCAATACT
TGTTGGTTTAGTGCTGTTATTCAGTCATTATTTAATCTTTTGGAATTTAGAAGATTAGTTCTGAATTACAAGCCTCCATCAAATGCTCAA
GATTTACCCCGAAACCAAAAGGAACATCGGAATTTGCCTTTTATGCGTGAGCTGAGGTATCTATTTGCACTTCTTGTTGGTACCAAAAGG
AAGTATGTTGATCCATCAAGAGCAGTTGAAATTCTTAAGGATGCTTTCAAATCAAATGACTCACAGCAGCAAGATGTGAGTGAGTTTACA
CACAAATTATTAGATTGGTTAGAAGATGCCTTCCAAATGAAAGCTGAAGAGGAGACGGATGAAGAGAAGCCAAAGAACCCCATGGTAGAG
TTGTTCTATGGCAGATTCCTGGCTGTGGGAGTACTTGAAGGTAAAAAATTTGAAAACACTGAAATGTTTGGTCAGTACCCACTTCAGGTC
AATGGGTTCAAAGATCTGCATGAGTGCCTAGAAGCTGCAATGATTGAAGGAGAAATTGAGTCTTTACATTCAGAGAATTCAGGAAAATCA
GGCCAAGAGGACCACCACCCTACGGTCACGACCACGAGATGGAATACTGTGCAGACTTGCCTCCTCCATACTCCCCCACCCCACAGGGTC
CAGCACAGCGTTCTCCACCCCCTCCTTATCCTGGAAACGCAAGGAAATAATCTATCTCCCAGAACAGAACATGTGCCAATGGGCGATCTT
GCCTGGAATAAAATGCCTCTACTCAGAAACAGGCAGGAAAGAATTGCTCCAAGGAATACTTTTTGGGGTCAGATAATGTGTCAGGTGGAA
TATCCCTGCTAGGAGATATAGGATTTCTACTCTGCTCAAAGCTGACCCCATCTGGAGTATTAATGTTTGGTTCTATGGAACCACATTTTA
AGAGATCTGCTGATCCACCTAAGCACATTCAGGGAAGAGTAATGTAATTGACAAAATATCTGATAATCATGTTGTTTAAGGGCTAGGTGA
AGAAAGTTTCAGTATTGATCCTGGAAAAAAAGAAGATCTAAGTAGGATGGGAGAATGATTTGGCCCACACAAGGAAGCAACTTTATTCTA
TATAGCTTTAAAAGTCAGAACTAGAATTGTTCATTCTTTCATTCATCAATAAATGTATTTTGAGTGCCTAAGAGTTTACTATGTGCCTAG
CACTGTTTGAGGTCCTGATGGAAGTTACAGGACGGGTACTCTGGTTTTAGTACAAGAAAGAGCAATGACTAGATTGCTTTGTGAAGCTCT
TGGTAGAGACACGCTCCAGAAGGGATAACAAAATCAAATAGTAGATGGGTTCATTGGGCCTCAGAAGTTCTGCTCGTATTTTAGGTGGGT
GTGAAGTGAATTTCTATATGTCCAGGAGTGAATACAACAGAAAGAGTTGGATCTTATTTATTTAATTAGGGAGTTAAAACAAGACCAAAA
AGACTCAACAGCCGCTTGAAGCCAAGAACTCTTCAATGCCAGCTACTGCCACCTAAAAATCATCTGGCTTTATAGTGGATCAGAATAAAG
GTTATTCTAACTGTGGGGAGAAAAAAAAAATTGTATCAAGTTCCACAGGTAGCAGACACTTCACTTCCAAGTAAAAGATGAGAAATCAAT
TATTCCCACAGGATTTTAGGTCAGGGAGCAAAAATCTCAGAACTTGACCATGAAGATACACAACAGACTCGCAAAAATAAAGTGGGAAAT
GAAGTTCAGATTCCCTTCTGTAGATTTCCTTAAAACTATTATTTTTTTCTTCTTCGTAAAATTTTGATAATCTGTTCTCTTAAAAAAGTT
AATGACACAATTAAGATACTGACATCAAATTGTTGCCTTTTACCAAAATGCAAATTTTATGAAGTGCCTACCTTTATATGTATAAAGCAT
TTAATAAATAATTCTAATGTGCCATATTTTGCTGTGAGTGACCTTAACATTTATATTTTTATATGAATTGTTTCATGTATTTATAAAAAT
TGTATATTGAACATTGGAAATAGATGATTAGATTTTTGTGTCATTTTACAATTAAATCTAAAATGCTTAATCCAATATCATCATCAAAAT
TCAGTGAAATCCCAAAACAGTGCCAAGAATTTTGCTGAATGAAACAATCAAACAAAGCATTTTAAGGTGTAAGTTATAGTACCTGTACTT
GCAGATAAGAAGCTTACTATATCATTATTATAAGTAGCATATATTACTTTCAAATACCTATATTAGAAAGATATTGATCTGACTGAAATA
TAACCTACCTGCCAGTAAGGTCCAAAGGCTGAATTTGTTTTGAATGAGTTCCTTGATCTTTAAGCACTGATGATTTTCTTATATATGAGG
ATGCAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTGAGGGGCTCCCTGACTTACATAAAGTTTTCAGTGCAATTTTAATAGTACATATGC
TTTAATTTATTTTTCTTCTGCGTGTGGTCAGACCCAATTACACTGTGGCTAAGACTCTCAAAGTGCCAGGGTTTCTGTGATGATTCTGAG
AATGCTGAATACAAATATACCTTATATTCTTTAAGGAAAACGGAAAGGAAAGATCAGCAGAAATAGGGTTTTCTCATCTTCACCATCAAT
AAACATTTATTGCGTACCTCCTATATTCTGCAAATTTTCCCCAAATAGAAGCCAGTTCAGTCCACACCATCTCTTCTTTGAGTTGTTTAT
GGCCTCCCTTAAGGCATTTTACAAACCCATAAGCCTACAATAGATGAGTATTTTTACTATTTGTATTAAGTGTCATAATAGCATCAATGT
GCACATTACCAGTATAGACTGTTGGAGTTCACTGATTGTTTTCATAGATGATGCTTCTTGGGGAAAAATAGTATAGGATGTGAAAGTTTT
GAATTACGGTTATTTAAAAACTAACATTTGCTATGGCCAAAGTGTTTACAATAAGCAATAAAGTGAAAGAACCTATTATAACACAGATTA

>97295_97295_3_USP25-CYYR1_USP25_chr21_17191165_ENST00000285681_CYYR1_chr21_27840950_ENST00000299340_length(amino acids)=510AA_BP=418
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLP
RNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFY
GRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEDHHPTVTTTRWNTVQTCLLHTPPPHRVQHS

--------------------------------------------------------------
>97295_97295_4_USP25-CYYR1_USP25_chr21_17191165_ENST00000285681_CYYR1_chr21_27840953_ENST00000299340_length(transcript)=3872nt_BP=1449nt
AAGCAGCCCGCGGACCGGCAGCAAAGGAACGTGCGAACGCGTGACGCCGCCCGACTGGCTCGCGCTCTCCCGTGCCCCGGCGTCCTCCGC
CCGCTCATGGCCCGGGCCGCCGCGGACGAGCGGCGCTGAGGCGGGCCGCGTGGAGACGTGAGGCGGCCGCCGTGGCCCTCACAGTCGGCG
TTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGCGGGGGCGCTGTCCTCCCAGGCCGTCCGC
GCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGGCGCCACCGCCGCCGCCGCCGCCGCCGCC
GCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCAGACGTTTTTGAATCAACTGAGAGAAATT
ACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGAATTAGCAGTGGCTTTCCTTACTGCGAAG
AATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGATAGATACATCAGTGTGGGAAGCCAAGCA
GATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTTGAGTTTGGCCGAATCAAACAGGGCATTC
AGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGCAGAGAATAAAGCATGTTTGAAGAGGACA
CCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCCCGTTGGGCTAAAGAATGTTGGCAATACT
TGTTGGTTTAGTGCTGTTATTCAGTCATTATTTAATCTTTTGGAATTTAGAAGATTAGTTCTGAATTACAAGCCTCCATCAAATGCTCAA
GATTTACCCCGAAACCAAAAGGAACATCGGAATTTGCCTTTTATGCGTGAGCTGAGGTATCTATTTGCACTTCTTGTTGGTACCAAAAGG
AAGTATGTTGATCCATCAAGAGCAGTTGAAATTCTTAAGGATGCTTTCAAATCAAATGACTCACAGCAGCAAGATGTGAGTGAGTTTACA
CACAAATTATTAGATTGGTTAGAAGATGCCTTCCAAATGAAAGCTGAAGAGGAGACGGATGAAGAGAAGCCAAAGAACCCCATGGTAGAG
TTGTTCTATGGCAGATTCCTGGCTGTGGGAGTACTTGAAGGTAAAAAATTTGAAAACACTGAAATGTTTGGTCAGTACCCACTTCAGGTC
AATGGGTTCAAAGATCTGCATGAGTGCCTAGAAGCTGCAATGATTGAAGGAGAAATTGAGTCTTTACATTCAGAGAATTCAGGAAAATCA
GGCCAAGAGGACCACCACCCTACGGTCACGACCACGAGATGGAATACTGTGCAGACTTGCCTCCTCCATACTCCCCCACCCCACAGGGTC
CAGCACAGCGTTCTCCACCCCCTCCTTATCCTGGAAACGCAAGGAAATAATCTATCTCCCAGAACAGAACATGTGCCAATGGGCGATCTT
GCCTGGAATAAAATGCCTCTACTCAGAAACAGGCAGGAAAGAATTGCTCCAAGGAATACTTTTTGGGGTCAGATAATGTGTCAGGTGGAA
TATCCCTGCTAGGAGATATAGGATTTCTACTCTGCTCAAAGCTGACCCCATCTGGAGTATTAATGTTTGGTTCTATGGAACCACATTTTA
AGAGATCTGCTGATCCACCTAAGCACATTCAGGGAAGAGTAATGTAATTGACAAAATATCTGATAATCATGTTGTTTAAGGGCTAGGTGA
AGAAAGTTTCAGTATTGATCCTGGAAAAAAAGAAGATCTAAGTAGGATGGGAGAATGATTTGGCCCACACAAGGAAGCAACTTTATTCTA
TATAGCTTTAAAAGTCAGAACTAGAATTGTTCATTCTTTCATTCATCAATAAATGTATTTTGAGTGCCTAAGAGTTTACTATGTGCCTAG
CACTGTTTGAGGTCCTGATGGAAGTTACAGGACGGGTACTCTGGTTTTAGTACAAGAAAGAGCAATGACTAGATTGCTTTGTGAAGCTCT
TGGTAGAGACACGCTCCAGAAGGGATAACAAAATCAAATAGTAGATGGGTTCATTGGGCCTCAGAAGTTCTGCTCGTATTTTAGGTGGGT
GTGAAGTGAATTTCTATATGTCCAGGAGTGAATACAACAGAAAGAGTTGGATCTTATTTATTTAATTAGGGAGTTAAAACAAGACCAAAA
AGACTCAACAGCCGCTTGAAGCCAAGAACTCTTCAATGCCAGCTACTGCCACCTAAAAATCATCTGGCTTTATAGTGGATCAGAATAAAG
GTTATTCTAACTGTGGGGAGAAAAAAAAAATTGTATCAAGTTCCACAGGTAGCAGACACTTCACTTCCAAGTAAAAGATGAGAAATCAAT
TATTCCCACAGGATTTTAGGTCAGGGAGCAAAAATCTCAGAACTTGACCATGAAGATACACAACAGACTCGCAAAAATAAAGTGGGAAAT
GAAGTTCAGATTCCCTTCTGTAGATTTCCTTAAAACTATTATTTTTTTCTTCTTCGTAAAATTTTGATAATCTGTTCTCTTAAAAAAGTT
AATGACACAATTAAGATACTGACATCAAATTGTTGCCTTTTACCAAAATGCAAATTTTATGAAGTGCCTACCTTTATATGTATAAAGCAT
TTAATAAATAATTCTAATGTGCCATATTTTGCTGTGAGTGACCTTAACATTTATATTTTTATATGAATTGTTTCATGTATTTATAAAAAT
TGTATATTGAACATTGGAAATAGATGATTAGATTTTTGTGTCATTTTACAATTAAATCTAAAATGCTTAATCCAATATCATCATCAAAAT
TCAGTGAAATCCCAAAACAGTGCCAAGAATTTTGCTGAATGAAACAATCAAACAAAGCATTTTAAGGTGTAAGTTATAGTACCTGTACTT
GCAGATAAGAAGCTTACTATATCATTATTATAAGTAGCATATATTACTTTCAAATACCTATATTAGAAAGATATTGATCTGACTGAAATA
TAACCTACCTGCCAGTAAGGTCCAAAGGCTGAATTTGTTTTGAATGAGTTCCTTGATCTTTAAGCACTGATGATTTTCTTATATATGAGG
ATGCAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTGAGGGGCTCCCTGACTTACATAAAGTTTTCAGTGCAATTTTAATAGTACATATGC
TTTAATTTATTTTTCTTCTGCGTGTGGTCAGACCCAATTACACTGTGGCTAAGACTCTCAAAGTGCCAGGGTTTCTGTGATGATTCTGAG
AATGCTGAATACAAATATACCTTATATTCTTTAAGGAAAACGGAAAGGAAAGATCAGCAGAAATAGGGTTTTCTCATCTTCACCATCAAT
AAACATTTATTGCGTACCTCCTATATTCTGCAAATTTTCCCCAAATAGAAGCCAGTTCAGTCCACACCATCTCTTCTTTGAGTTGTTTAT
GGCCTCCCTTAAGGCATTTTACAAACCCATAAGCCTACAATAGATGAGTATTTTTACTATTTGTATTAAGTGTCATAATAGCATCAATGT
GCACATTACCAGTATAGACTGTTGGAGTTCACTGATTGTTTTCATAGATGATGCTTCTTGGGGAAAAATAGTATAGGATGTGAAAGTTTT
GAATTACGGTTATTTAAAAACTAACATTTGCTATGGCCAAAGTGTTTACAATAAGCAATAAAGTGAAAGAACCTATTATAACACAGATTA

>97295_97295_4_USP25-CYYR1_USP25_chr21_17191165_ENST00000285681_CYYR1_chr21_27840953_ENST00000299340_length(amino acids)=510AA_BP=418
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLP
RNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFY
GRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEDHHPTVTTTRWNTVQTCLLHTPPPHRVQHS

--------------------------------------------------------------
>97295_97295_5_USP25-CYYR1_USP25_chr21_17191165_ENST00000400183_CYYR1_chr21_27840950_ENST00000299340_length(transcript)=3720nt_BP=1297nt
GCGGCCGCCGTGGCCCTCACAGTCGGCGTTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGC
GGGGGCGCTGTCCTCCCAGGCCGTCCGCGCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGG
CGCCACCGCCGCCGCCGCCGCCGCCGCCGCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCA
GACGTTTTTGAATCAACTGAGAGAAATTACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGA
ATTAGCAGTGGCTTTCCTTACTGCGAAGAATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGA
TAGATACATCAGTGTGGGAAGCCAAGCAGATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTT
GAGTTTGGCCGAATCAAACAGGGCATTCAGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGC
AGAGAATAAAGCATGTTTGAAGAGGACACCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCC
CGTTGGGCTAAAGAATGTTGGCAATACTTGTTGGTTTAGTGCTGTTATTCAGTCATTATTTAATCTTTTGGAATTTAGAAGATTAGTTCT
GAATTACAAGCCTCCATCAAATGCTCAAGATTTACCCCGAAACCAAAAGGAACATCGGAATTTGCCTTTTATGCGTGAGCTGAGGTATCT
ATTTGCACTTCTTGTTGGTACCAAAAGGAAGTATGTTGATCCATCAAGAGCAGTTGAAATTCTTAAGGATGCTTTCAAATCAAATGACTC
ACAGCAGCAAGATGTGAGTGAGTTTACACACAAATTATTAGATTGGTTAGAAGATGCCTTCCAAATGAAAGCTGAAGAGGAGACGGATGA
AGAGAAGCCAAAGAACCCCATGGTAGAGTTGTTCTATGGCAGATTCCTGGCTGTGGGAGTACTTGAAGGTAAAAAATTTGAAAACACTGA
AATGTTTGGTCAGTACCCACTTCAGGTCAATGGGTTCAAAGATCTGCATGAGTGCCTAGAAGCTGCAATGATTGAAGGAGAAATTGAGTC
TTTACATTCAGAGAATTCAGGAAAATCAGGCCAAGAGGACCACCACCCTACGGTCACGACCACGAGATGGAATACTGTGCAGACTTGCCT
CCTCCATACTCCCCCACCCCACAGGGTCCAGCACAGCGTTCTCCACCCCCTCCTTATCCTGGAAACGCAAGGAAATAATCTATCTCCCAG
AACAGAACATGTGCCAATGGGCGATCTTGCCTGGAATAAAATGCCTCTACTCAGAAACAGGCAGGAAAGAATTGCTCCAAGGAATACTTT
TTGGGGTCAGATAATGTGTCAGGTGGAATATCCCTGCTAGGAGATATAGGATTTCTACTCTGCTCAAAGCTGACCCCATCTGGAGTATTA
ATGTTTGGTTCTATGGAACCACATTTTAAGAGATCTGCTGATCCACCTAAGCACATTCAGGGAAGAGTAATGTAATTGACAAAATATCTG
ATAATCATGTTGTTTAAGGGCTAGGTGAAGAAAGTTTCAGTATTGATCCTGGAAAAAAAGAAGATCTAAGTAGGATGGGAGAATGATTTG
GCCCACACAAGGAAGCAACTTTATTCTATATAGCTTTAAAAGTCAGAACTAGAATTGTTCATTCTTTCATTCATCAATAAATGTATTTTG
AGTGCCTAAGAGTTTACTATGTGCCTAGCACTGTTTGAGGTCCTGATGGAAGTTACAGGACGGGTACTCTGGTTTTAGTACAAGAAAGAG
CAATGACTAGATTGCTTTGTGAAGCTCTTGGTAGAGACACGCTCCAGAAGGGATAACAAAATCAAATAGTAGATGGGTTCATTGGGCCTC
AGAAGTTCTGCTCGTATTTTAGGTGGGTGTGAAGTGAATTTCTATATGTCCAGGAGTGAATACAACAGAAAGAGTTGGATCTTATTTATT
TAATTAGGGAGTTAAAACAAGACCAAAAAGACTCAACAGCCGCTTGAAGCCAAGAACTCTTCAATGCCAGCTACTGCCACCTAAAAATCA
TCTGGCTTTATAGTGGATCAGAATAAAGGTTATTCTAACTGTGGGGAGAAAAAAAAAATTGTATCAAGTTCCACAGGTAGCAGACACTTC
ACTTCCAAGTAAAAGATGAGAAATCAATTATTCCCACAGGATTTTAGGTCAGGGAGCAAAAATCTCAGAACTTGACCATGAAGATACACA
ACAGACTCGCAAAAATAAAGTGGGAAATGAAGTTCAGATTCCCTTCTGTAGATTTCCTTAAAACTATTATTTTTTTCTTCTTCGTAAAAT
TTTGATAATCTGTTCTCTTAAAAAAGTTAATGACACAATTAAGATACTGACATCAAATTGTTGCCTTTTACCAAAATGCAAATTTTATGA
AGTGCCTACCTTTATATGTATAAAGCATTTAATAAATAATTCTAATGTGCCATATTTTGCTGTGAGTGACCTTAACATTTATATTTTTAT
ATGAATTGTTTCATGTATTTATAAAAATTGTATATTGAACATTGGAAATAGATGATTAGATTTTTGTGTCATTTTACAATTAAATCTAAA
ATGCTTAATCCAATATCATCATCAAAATTCAGTGAAATCCCAAAACAGTGCCAAGAATTTTGCTGAATGAAACAATCAAACAAAGCATTT
TAAGGTGTAAGTTATAGTACCTGTACTTGCAGATAAGAAGCTTACTATATCATTATTATAAGTAGCATATATTACTTTCAAATACCTATA
TTAGAAAGATATTGATCTGACTGAAATATAACCTACCTGCCAGTAAGGTCCAAAGGCTGAATTTGTTTTGAATGAGTTCCTTGATCTTTA
AGCACTGATGATTTTCTTATATATGAGGATGCAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTGAGGGGCTCCCTGACTTACATAAAGTT
TTCAGTGCAATTTTAATAGTACATATGCTTTAATTTATTTTTCTTCTGCGTGTGGTCAGACCCAATTACACTGTGGCTAAGACTCTCAAA
GTGCCAGGGTTTCTGTGATGATTCTGAGAATGCTGAATACAAATATACCTTATATTCTTTAAGGAAAACGGAAAGGAAAGATCAGCAGAA
ATAGGGTTTTCTCATCTTCACCATCAATAAACATTTATTGCGTACCTCCTATATTCTGCAAATTTTCCCCAAATAGAAGCCAGTTCAGTC
CACACCATCTCTTCTTTGAGTTGTTTATGGCCTCCCTTAAGGCATTTTACAAACCCATAAGCCTACAATAGATGAGTATTTTTACTATTT
GTATTAAGTGTCATAATAGCATCAATGTGCACATTACCAGTATAGACTGTTGGAGTTCACTGATTGTTTTCATAGATGATGCTTCTTGGG
GAAAAATAGTATAGGATGTGAAAGTTTTGAATTACGGTTATTTAAAAACTAACATTTGCTATGGCCAAAGTGTTTACAATAAGCAATAAA

>97295_97295_5_USP25-CYYR1_USP25_chr21_17191165_ENST00000400183_CYYR1_chr21_27840950_ENST00000299340_length(amino acids)=510AA_BP=418
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLP
RNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFY
GRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEDHHPTVTTTRWNTVQTCLLHTPPPHRVQHS

--------------------------------------------------------------
>97295_97295_6_USP25-CYYR1_USP25_chr21_17191165_ENST00000400183_CYYR1_chr21_27840953_ENST00000299340_length(transcript)=3720nt_BP=1297nt
GCGGCCGCCGTGGCCCTCACAGTCGGCGTTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGC
GGGGGCGCTGTCCTCCCAGGCCGTCCGCGCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGG
CGCCACCGCCGCCGCCGCCGCCGCCGCCGCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCA
GACGTTTTTGAATCAACTGAGAGAAATTACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGA
ATTAGCAGTGGCTTTCCTTACTGCGAAGAATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGA
TAGATACATCAGTGTGGGAAGCCAAGCAGATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTT
GAGTTTGGCCGAATCAAACAGGGCATTCAGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGC
AGAGAATAAAGCATGTTTGAAGAGGACACCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCC
CGTTGGGCTAAAGAATGTTGGCAATACTTGTTGGTTTAGTGCTGTTATTCAGTCATTATTTAATCTTTTGGAATTTAGAAGATTAGTTCT
GAATTACAAGCCTCCATCAAATGCTCAAGATTTACCCCGAAACCAAAAGGAACATCGGAATTTGCCTTTTATGCGTGAGCTGAGGTATCT
ATTTGCACTTCTTGTTGGTACCAAAAGGAAGTATGTTGATCCATCAAGAGCAGTTGAAATTCTTAAGGATGCTTTCAAATCAAATGACTC
ACAGCAGCAAGATGTGAGTGAGTTTACACACAAATTATTAGATTGGTTAGAAGATGCCTTCCAAATGAAAGCTGAAGAGGAGACGGATGA
AGAGAAGCCAAAGAACCCCATGGTAGAGTTGTTCTATGGCAGATTCCTGGCTGTGGGAGTACTTGAAGGTAAAAAATTTGAAAACACTGA
AATGTTTGGTCAGTACCCACTTCAGGTCAATGGGTTCAAAGATCTGCATGAGTGCCTAGAAGCTGCAATGATTGAAGGAGAAATTGAGTC
TTTACATTCAGAGAATTCAGGAAAATCAGGCCAAGAGGACCACCACCCTACGGTCACGACCACGAGATGGAATACTGTGCAGACTTGCCT
CCTCCATACTCCCCCACCCCACAGGGTCCAGCACAGCGTTCTCCACCCCCTCCTTATCCTGGAAACGCAAGGAAATAATCTATCTCCCAG
AACAGAACATGTGCCAATGGGCGATCTTGCCTGGAATAAAATGCCTCTACTCAGAAACAGGCAGGAAAGAATTGCTCCAAGGAATACTTT
TTGGGGTCAGATAATGTGTCAGGTGGAATATCCCTGCTAGGAGATATAGGATTTCTACTCTGCTCAAAGCTGACCCCATCTGGAGTATTA
ATGTTTGGTTCTATGGAACCACATTTTAAGAGATCTGCTGATCCACCTAAGCACATTCAGGGAAGAGTAATGTAATTGACAAAATATCTG
ATAATCATGTTGTTTAAGGGCTAGGTGAAGAAAGTTTCAGTATTGATCCTGGAAAAAAAGAAGATCTAAGTAGGATGGGAGAATGATTTG
GCCCACACAAGGAAGCAACTTTATTCTATATAGCTTTAAAAGTCAGAACTAGAATTGTTCATTCTTTCATTCATCAATAAATGTATTTTG
AGTGCCTAAGAGTTTACTATGTGCCTAGCACTGTTTGAGGTCCTGATGGAAGTTACAGGACGGGTACTCTGGTTTTAGTACAAGAAAGAG
CAATGACTAGATTGCTTTGTGAAGCTCTTGGTAGAGACACGCTCCAGAAGGGATAACAAAATCAAATAGTAGATGGGTTCATTGGGCCTC
AGAAGTTCTGCTCGTATTTTAGGTGGGTGTGAAGTGAATTTCTATATGTCCAGGAGTGAATACAACAGAAAGAGTTGGATCTTATTTATT
TAATTAGGGAGTTAAAACAAGACCAAAAAGACTCAACAGCCGCTTGAAGCCAAGAACTCTTCAATGCCAGCTACTGCCACCTAAAAATCA
TCTGGCTTTATAGTGGATCAGAATAAAGGTTATTCTAACTGTGGGGAGAAAAAAAAAATTGTATCAAGTTCCACAGGTAGCAGACACTTC
ACTTCCAAGTAAAAGATGAGAAATCAATTATTCCCACAGGATTTTAGGTCAGGGAGCAAAAATCTCAGAACTTGACCATGAAGATACACA
ACAGACTCGCAAAAATAAAGTGGGAAATGAAGTTCAGATTCCCTTCTGTAGATTTCCTTAAAACTATTATTTTTTTCTTCTTCGTAAAAT
TTTGATAATCTGTTCTCTTAAAAAAGTTAATGACACAATTAAGATACTGACATCAAATTGTTGCCTTTTACCAAAATGCAAATTTTATGA
AGTGCCTACCTTTATATGTATAAAGCATTTAATAAATAATTCTAATGTGCCATATTTTGCTGTGAGTGACCTTAACATTTATATTTTTAT
ATGAATTGTTTCATGTATTTATAAAAATTGTATATTGAACATTGGAAATAGATGATTAGATTTTTGTGTCATTTTACAATTAAATCTAAA
ATGCTTAATCCAATATCATCATCAAAATTCAGTGAAATCCCAAAACAGTGCCAAGAATTTTGCTGAATGAAACAATCAAACAAAGCATTT
TAAGGTGTAAGTTATAGTACCTGTACTTGCAGATAAGAAGCTTACTATATCATTATTATAAGTAGCATATATTACTTTCAAATACCTATA
TTAGAAAGATATTGATCTGACTGAAATATAACCTACCTGCCAGTAAGGTCCAAAGGCTGAATTTGTTTTGAATGAGTTCCTTGATCTTTA
AGCACTGATGATTTTCTTATATATGAGGATGCAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTGAGGGGCTCCCTGACTTACATAAAGTT
TTCAGTGCAATTTTAATAGTACATATGCTTTAATTTATTTTTCTTCTGCGTGTGGTCAGACCCAATTACACTGTGGCTAAGACTCTCAAA
GTGCCAGGGTTTCTGTGATGATTCTGAGAATGCTGAATACAAATATACCTTATATTCTTTAAGGAAAACGGAAAGGAAAGATCAGCAGAA
ATAGGGTTTTCTCATCTTCACCATCAATAAACATTTATTGCGTACCTCCTATATTCTGCAAATTTTCCCCAAATAGAAGCCAGTTCAGTC
CACACCATCTCTTCTTTGAGTTGTTTATGGCCTCCCTTAAGGCATTTTACAAACCCATAAGCCTACAATAGATGAGTATTTTTACTATTT
GTATTAAGTGTCATAATAGCATCAATGTGCACATTACCAGTATAGACTGTTGGAGTTCACTGATTGTTTTCATAGATGATGCTTCTTGGG
GAAAAATAGTATAGGATGTGAAAGTTTTGAATTACGGTTATTTAAAAACTAACATTTGCTATGGCCAAAGTGTTTACAATAAGCAATAAA

>97295_97295_6_USP25-CYYR1_USP25_chr21_17191165_ENST00000400183_CYYR1_chr21_27840953_ENST00000299340_length(amino acids)=510AA_BP=418
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLP
RNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFY
GRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEDHHPTVTTTRWNTVQTCLLHTPPPHRVQHS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USP25-CYYR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP25-CYYR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP25-CYYR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource