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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP25-DZIP3 (FusionGDB2 ID:97297)

Fusion Gene Summary for USP25-DZIP3

check button Fusion gene summary
Fusion gene informationFusion gene name: USP25-DZIP3
Fusion gene ID: 97297
HgeneTgene
Gene symbol

USP25

DZIP3

Gene ID

29761

9666

Gene nameubiquitin specific peptidase 25DAZ interacting zinc finger protein 3
SynonymsUSP21PPP1R66|UURF2|hRUL138
Cytomap

21q21.1

3q13.13

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 25USP on chromosome 21deubiquitinating enzyme 25ubiquitin thioesterase 25ubiquitin thiolesterase 25ubiquitin-specific processing protease 25E3 ubiquitin-protein ligase DZIP3DAZ interacting protein 3, zinc fingerDAZ-interacting protein 3RING-type E3 ubiquitin transferase DZIP3RNA-binding RING-H2 protein-ubiquitin ligaseRNA-binding ubiquitin ligase of 138 kDaUURF2 ubiquitin ligasehuman R
Modification date2020031320200327
UniProtAcc.

Q86Y13

Ensembl transtripts involved in fusion geneENST00000547201, ENST00000285679, 
ENST00000285681, ENST00000351097, 
ENST00000400183, 		ENST00000361582, 
ENST00000463306, 
Fusion gene scores* DoF score13 X 10 X 9=11703 X 3 X 2=18
# samples 133
** MAII scorelog2(13/1170*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: USP25 [Title/Abstract] AND DZIP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP25(17163983)-DZIP3(108392925), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP25

GO:0016579

protein deubiquitination

22590560

TgeneDZIP3

GO:0000209

protein polyubiquitination

12538761


check buttonFusion gene breakpoints across USP25 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DZIP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-FI-A3PX-01AUSP25chr21

17163983

-DZIP3chr3

108392925

+
ChimerDB4UCECTCGA-FI-A3PX-01AUSP25chr21

17163983

+DZIP3chr3

108392925

+


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Fusion Gene ORF analysis for USP25-DZIP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000547201ENST00000361582USP25chr21

17163983

+DZIP3chr3

108392925

+
3UTR-3CDSENST00000547201ENST00000463306USP25chr21

17163983

+DZIP3chr3

108392925

+
In-frameENST00000285679ENST00000361582USP25chr21

17163983

+DZIP3chr3

108392925

+
In-frameENST00000285679ENST00000463306USP25chr21

17163983

+DZIP3chr3

108392925

+
In-frameENST00000285681ENST00000361582USP25chr21

17163983

+DZIP3chr3

108392925

+
In-frameENST00000285681ENST00000463306USP25chr21

17163983

+DZIP3chr3

108392925

+
In-frameENST00000351097ENST00000361582USP25chr21

17163983

+DZIP3chr3

108392925

+
In-frameENST00000351097ENST00000463306USP25chr21

17163983

+DZIP3chr3

108392925

+
In-frameENST00000400183ENST00000361582USP25chr21

17163983

+DZIP3chr3

108392925

+
In-frameENST00000400183ENST00000463306USP25chr21

17163983

+DZIP3chr3

108392925

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000351097USP25chr2117163983+ENST00000361582DZIP3chr3108392925+34559241891961590
ENST00000351097USP25chr2117163983+ENST00000463306DZIP3chr3108392925+24529241891961590
ENST00000285679USP25chr2117163983+ENST00000361582DZIP3chr3108392925+34559241891961590
ENST00000285679USP25chr2117163983+ENST00000463306DZIP3chr3108392925+24529241891961590
ENST00000285681USP25chr2117163983+ENST00000361582DZIP3chr3108392925+34559241891961590
ENST00000285681USP25chr2117163983+ENST00000463306DZIP3chr3108392925+24529241891961590
ENST00000400183USP25chr2117163983+ENST00000361582DZIP3chr3108392925+3303772371809590
ENST00000400183USP25chr2117163983+ENST00000463306DZIP3chr3108392925+2300772371809590

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000351097ENST00000361582USP25chr2117163983+DZIP3chr3108392925+0.0006412610.9993587
ENST00000351097ENST00000463306USP25chr2117163983+DZIP3chr3108392925+0.0031449270.996855
ENST00000285679ENST00000361582USP25chr2117163983+DZIP3chr3108392925+0.0006412610.9993587
ENST00000285679ENST00000463306USP25chr2117163983+DZIP3chr3108392925+0.0031449270.996855
ENST00000285681ENST00000361582USP25chr2117163983+DZIP3chr3108392925+0.0006412610.9993587
ENST00000285681ENST00000463306USP25chr2117163983+DZIP3chr3108392925+0.0031449270.996855
ENST00000400183ENST00000361582USP25chr2117163983+DZIP3chr3108392925+0.0005179830.9994821
ENST00000400183ENST00000463306USP25chr2117163983+DZIP3chr3108392925+0.0023545260.99764544

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Fusion Genomic Features for USP25-DZIP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
USP25chr2117163983+DZIP3chr3108392924+0.0009139180.999086
USP25chr2117163983+DZIP3chr3108392924+0.0009139180.999086

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for USP25-DZIP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:17163983/chr3:108392925)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DZIP3

Q86Y13

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. {ECO:0000269|PubMed:12538761}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP25chr21:17163983chr3:108392925ENST00000285679+524123_1401851056.0DomainUIM 2
HgeneUSP25chr21:17163983chr3:108392925ENST00000285679+52414_571851056.0DomainNote=UBA-like
HgeneUSP25chr21:17163983chr3:108392925ENST00000285679+52497_1161851056.0DomainUIM 1
HgeneUSP25chr21:17163983chr3:108392925ENST00000285681+525123_1401851088.0DomainUIM 2
HgeneUSP25chr21:17163983chr3:108392925ENST00000285681+52514_571851088.0DomainNote=UBA-like
HgeneUSP25chr21:17163983chr3:108392925ENST00000285681+52597_1161851088.0DomainUIM 1
HgeneUSP25chr21:17163983chr3:108392925ENST00000400183+526123_1401851126.0DomainUIM 2
HgeneUSP25chr21:17163983chr3:108392925ENST00000400183+52614_571851126.0DomainNote=UBA-like
HgeneUSP25chr21:17163983chr3:108392925ENST00000400183+52697_1161851126.0DomainUIM 1
HgeneUSP25chr21:17163983chr3:108392925ENST00000285679+52489_951851056.0MotifNote=Required for SUMO paralog-specific binding
HgeneUSP25chr21:17163983chr3:108392925ENST00000285681+52589_951851088.0MotifNote=Required for SUMO paralog-specific binding
HgeneUSP25chr21:17163983chr3:108392925ENST00000400183+52689_951851126.0MotifNote=Required for SUMO paralog-specific binding
TgeneDZIP3chr21:17163983chr3:108392925ENST000003615822233904_9398631652.0Coiled coilOntology_term=ECO:0000255
TgeneDZIP3chr21:17163983chr3:108392925ENST000004633062232904_9398631209.0Coiled coilOntology_term=ECO:0000255
TgeneDZIP3chr21:17163983chr3:108392925ENST0000036158222331140_11468631652.0Compositional biasNote=Poly-Glu
TgeneDZIP3chr21:17163983chr3:108392925ENST000003615822233952_9588631652.0Compositional biasNote=Poly-Pro
TgeneDZIP3chr21:17163983chr3:108392925ENST0000046330622321140_11468631209.0Compositional biasNote=Poly-Glu
TgeneDZIP3chr21:17163983chr3:108392925ENST000004633062232952_9588631209.0Compositional biasNote=Poly-Pro
TgeneDZIP3chr21:17163983chr3:108392925ENST0000036158222331148_11888631652.0Zinc fingerRING-type%3B atypical
TgeneDZIP3chr21:17163983chr3:108392925ENST0000046330622321148_11888631209.0Zinc fingerRING-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP25chr21:17163983chr3:108392925ENST00000285679+524541_5781851056.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17163983chr3:108392925ENST00000285679+524684_7171851056.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17163983chr3:108392925ENST00000285681+525541_5781851088.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17163983chr3:108392925ENST00000285681+525684_7171851088.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17163983chr3:108392925ENST00000400183+526541_5781851126.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17163983chr3:108392925ENST00000400183+526684_7171851126.0Coiled coilOntology_term=ECO:0000255
HgeneUSP25chr21:17163983chr3:108392925ENST00000285679+524169_6571851056.0DomainNote=USP
HgeneUSP25chr21:17163983chr3:108392925ENST00000285681+525169_6571851088.0DomainNote=USP
HgeneUSP25chr21:17163983chr3:108392925ENST00000400183+526169_6571851126.0DomainNote=USP
TgeneDZIP3chr21:17163983chr3:108392925ENST00000361582223314_438631652.0Coiled coilOntology_term=ECO:0000255
TgeneDZIP3chr21:17163983chr3:108392925ENST000003615822233647_6768631652.0Coiled coilOntology_term=ECO:0000255
TgeneDZIP3chr21:17163983chr3:108392925ENST000003615822233792_8538631652.0Coiled coilOntology_term=ECO:0000255
TgeneDZIP3chr21:17163983chr3:108392925ENST00000463306223214_438631209.0Coiled coilOntology_term=ECO:0000255
TgeneDZIP3chr21:17163983chr3:108392925ENST000004633062232647_6768631209.0Coiled coilOntology_term=ECO:0000255
TgeneDZIP3chr21:17163983chr3:108392925ENST000004633062232792_8538631209.0Coiled coilOntology_term=ECO:0000255
TgeneDZIP3chr21:17163983chr3:108392925ENST000003615822233607_6108631652.0Compositional biasNote=Poly-Glu
TgeneDZIP3chr21:17163983chr3:108392925ENST000003615822233661_6718631652.0Compositional biasNote=Poly-Lys
TgeneDZIP3chr21:17163983chr3:108392925ENST000004633062232607_6108631209.0Compositional biasNote=Poly-Glu
TgeneDZIP3chr21:17163983chr3:108392925ENST000004633062232661_6718631209.0Compositional biasNote=Poly-Lys


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Fusion Gene Sequence for USP25-DZIP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97297_97297_1_USP25-DZIP3_USP25_chr21_17163983_ENST00000285679_DZIP3_chr3_108392925_ENST00000361582_length(transcript)=3455nt_BP=924nt
AAGCAGCCCGCGGACCGGCAGCAAAGGAACGTGCGAACGCGTGACGCCGCCCGACTGGCTCGCGCTCTCCCGTGCCCCGGCGTCCTCCGC
CCGCTCATGGCCCGGGCCGCCGCGGACGAGCGGCGCTGAGGCGGGCCGCGTGGAGACGTGAGGCGGCCGCCGTGGCCCTCACAGTCGGCG
TTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGCGGGGGCGCTGTCCTCCCAGGCCGTCCGC
GCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGGCGCCACCGCCGCCGCCGCCGCCGCCGCC
GCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCAGACGTTTTTGAATCAACTGAGAGAAATT
ACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGAATTAGCAGTGGCTTTCCTTACTGCGAAG
AATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGATAGATACATCAGTGTGGGAAGCCAAGCA
GATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTTGAGTTTGGCCGAATCAAACAGGGCATTC
AGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGCAGAGAATAAAGCATGTTTGAAGAGGACA
CCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCCCGTTGGGCTAAAGAATGTTGGCAATACT
TGTTGGTTTAGTGCTGTTATTCAGGTGTATTTCTTACAGTGTCGTAGGGATTTTGGTTTGCTTCATCTAGAGCAGACTGAAAAGGAATGT
CTCAATCAGCTTGCCAGGGTGACTCACATGGCAGCAAGCAACCTAGAATCACTTCAATTAAAGGCTGCGGTAGACAGTTGGAATGCCATT
GTGGCAGATGTTAGAAACAAGATTGCATTCCTCAGGACACAGTACAATGAACAAATAAACAAAGTCAAGCAAGGATTTGCCTTGAGTACC
TTGCCTCCAGTCCAGCTTCCTCCTCCACCACCCAGTCCTGAGATACTGATGCAGCAGTTCTTAGGAAGACCTCTTGTGAAAGAATCTTTC
TTTAGACCCATACTTACTGTTCCTCAAATGCCTGCAGTTTGCCCGGGAGTCGTCTCTGCAACTGGCCAACCTAGAGCCCCCCTGATGACT
GGCATAGCCTGGGCTCTGCCAGCGCCTGTGGGAGACGCTGTGCCTCCCAGTGCAGGTCTGCGGAGTGATCCCTCCATCATGAATTGGGAG
AGAATTACAGACAGGCTGAAAACTGCCTTTCCACAGCAAACCAGAAAGGAACTTACAGATTTCTTACGGAAATTGAAGGATGCTTATGGA
AAATCCTTGTCTGAACTGACATTTGATGAAATTGTTTGCAAGATTTCCCAGTTTATTGACCCCAAAAAGTCTCAGAGTCAAGGAAAATCA
GTGTCAAATGTTAATTGTGTTTCACCTAGTCATTCTCCATCACAGCCTGATGCTGCCCAGCCCCCAAAACCAGCCTGGAGGCCACTCACT
TCACAGGGTCCTGCCACATGGGAAGGAGCCAGTAATCCAGATGAGGAAGAGGAAGAAGAAGAGCCTTGTGTGATCTGTCATGAGAATCTG
TCTCCAGAAAATCTTTCAGTTTTGCCTTGCGCTCACAAATTCCATGCTCAGTGCATTAGACCATGGTTGATGCAACAGGGGACATGTCCA
ACGTGCAGACTCCACGTTTTGCTACCAGAAGAATTCCCTGGTCACCCCAGCCGGCAGTTGCCCAAGATCTGATACAAGGTACCCATGAAG
AGATTATGAACTACTTGAAGGTGGAGACTGTACGGTGGTGTGTTGGAGCTGGCTTGTAATGTCTTATGAGTGACAATCGTTAGTTTGAGG
AATTTTGTGAGACAGTTGTCAAATTGTTGCTAGCTTGAAATCTGCGGCAATTGGAGTATTTACACCATAGAAATGCTATAAGTGAAGACC
TACCTTTCCCTTAAGAGCTAGTTGTTAAACCTTTACCAGCATACCACTGGACCTTGTCTAAAATTTCTTTGTGTTCCCAGTGTCTTGCCC
AGTAGATACAAGATAAATATTGCCAGAATCAGATATCAGGAAGTAGTAAGAAAAGGAGTTAATATGCAAACTAAATCACTCGCTCAATTG
AATAATTGAGATCTTCTGTTCATTTGTTCCTTGGACCTTAATCATTTGCATTTTGGAGAAAATTTTTTCTGCTTTAAAAGTCTGTAATTT
CAGTTTTTGTGTCGGGGAGAGGGAAAAACTATTTGTCTGTAGTTGCTTTTTGTGACAAAGTGAATACCCACTGGGCTAAGTTTCATATCT
AAAGCTTGTCACTAAGAATTTTCATTTTTAGGGGTCAAAAACCTATTTTGAAAATAGTGTTGTGTGAATGCTGTAAGTGTTGTACATGTC
TCTGGTTTCAGAATTAAAAGAATTCAGAGTTACCTTGTGAGATAAATGTTCTTTGCTTCATATTCACAGTTTCACCTCCATTTAAATTTA
TGGGGAAGAATAAATGTTTCCTGACTCAGAAACAATTTTGCCTCCATATTTCAGTGCAAATATATTTTGAAGTTACTTTTAAATATTTAT
TTAAAACCTCTGTTTCTGTAACTGTATGTTAAACGTATTCTTCTGTAATGAGAATAGACTGGAACATGTGAGGGAAAAATATTTAAAAAA
AGATGGCAGTCATCTAGACATGTAAAATGCCAAGAATGTCTTAGAATTGCACAATTTAGAATTTATAGAGCCTTTAATCACCTTGTCTAG
CACCTTGTATTAGTCCATTTTCATGCTGCTGATAAAGACATACCTGAGATTGGGCAATTTACAAAAGAAAGAGGTTTAACGGACTTACAG
TTCCACATGACTAAGGAGGCCTCACAATCATGGTGGAAGGCAAAGAGGAGCAAGTCACATCTTACATGGATGGCAGCAGACAAGGAGAGA
GAGCTTGTGCAGGGAAACTCCCATTTTTAAAACCATCAGATCTCATGAGGCTTACTATCACGAGAACAGCATGGGAAAGACCTGCCCCCG
TGATTAAATTATTTCCCACCAGGCCCCTCCCACAACATGGAATAATGGGAGATACAAGATATTTGGGTGGAGACACAGAGCCAAACCATA
TCACACCTTAAGGTCATGGTCATATAGCTAGTTATCTTGTAAAACCAATGTTTCTTAGTTCATACTTACAACTGCAATTTCACTTTCATT

>97297_97297_1_USP25-DZIP3_USP25_chr21_17163983_ENST00000285679_DZIP3_chr3_108392925_ENST00000361582_length(amino acids)=590AA_BP=245
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQVYFLQCRRDFGLLHLEQTEKECLNQ
LARVTHMAASNLESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILMQQFLGRPLVKESFFRP
ILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVPPSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSL
SELTFDEIVCKISQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDEEEEEEEPCVICHENLSPE

--------------------------------------------------------------
>97297_97297_2_USP25-DZIP3_USP25_chr21_17163983_ENST00000285679_DZIP3_chr3_108392925_ENST00000463306_length(transcript)=2452nt_BP=924nt
AAGCAGCCCGCGGACCGGCAGCAAAGGAACGTGCGAACGCGTGACGCCGCCCGACTGGCTCGCGCTCTCCCGTGCCCCGGCGTCCTCCGC
CCGCTCATGGCCCGGGCCGCCGCGGACGAGCGGCGCTGAGGCGGGCCGCGTGGAGACGTGAGGCGGCCGCCGTGGCCCTCACAGTCGGCG
TTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGCGGGGGCGCTGTCCTCCCAGGCCGTCCGC
GCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGGCGCCACCGCCGCCGCCGCCGCCGCCGCC
GCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCAGACGTTTTTGAATCAACTGAGAGAAATT
ACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGAATTAGCAGTGGCTTTCCTTACTGCGAAG
AATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGATAGATACATCAGTGTGGGAAGCCAAGCA
GATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTTGAGTTTGGCCGAATCAAACAGGGCATTC
AGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGCAGAGAATAAAGCATGTTTGAAGAGGACA
CCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCCCGTTGGGCTAAAGAATGTTGGCAATACT
TGTTGGTTTAGTGCTGTTATTCAGGTGTATTTCTTACAGTGTCGTAGGGATTTTGGTTTGCTTCATCTAGAGCAGACTGAAAAGGAATGT
CTCAATCAGCTTGCCAGGGTGACTCACATGGCAGCAAGCAACCTAGAATCACTTCAATTAAAGGCTGCGGTAGACAGTTGGAATGCCATT
GTGGCAGATGTTAGAAACAAGATTGCATTCCTCAGGACACAGTACAATGAACAAATAAACAAAGTCAAGCAAGGATTTGCCTTGAGTACC
TTGCCTCCAGTCCAGCTTCCTCCTCCACCACCCAGTCCTGAGATACTGATGCAGCAGTTCTTAGGAAGACCTCTTGTGAAAGAATCTTTC
TTTAGACCCATACTTACTGTTCCTCAAATGCCTGCAGTTTGCCCGGGAGTCGTCTCTGCAACTGGCCAACCTAGAGCCCCCCTGATGACT
GGCATAGCCTGGGCTCTGCCAGCGCCTGTGGGAGACGCTGTGCCTCCCAGTGCAGGTCTGCGGAGTGATCCCTCCATCATGAATTGGGAG
AGAATTACAGACAGGCTGAAAACTGCCTTTCCACAGCAAACCAGAAAGGAACTTACAGATTTCTTACGGAAATTGAAGGATGCTTATGGA
AAATCCTTGTCTGAACTGACATTTGATGAAATTGTTTGCAAGATTTCCCAGTTTATTGACCCCAAAAAGTCTCAGAGTCAAGGAAAATCA
GTGTCAAATGTTAATTGTGTTTCACCTAGTCATTCTCCATCACAGCCTGATGCTGCCCAGCCCCCAAAACCAGCCTGGAGGCCACTCACT
TCACAGGGTCCTGCCACATGGGAAGGAGCCAGTAATCCAGATGAGGAAGAGGAAGAAGAAGAGCCTTGTGTGATCTGTCATGAGAATCTG
TCTCCAGAAAATCTTTCAGTTTTGCCTTGCGCTCACAAATTCCATGCTCAGTGCATTAGACCATGGTTGATGCAACAGGGGACATGTCCA
ACGTGCAGACTCCACGTTTTGCTACCAGAAGAATTCCCTGGTCACCCCAGCCGGCAGTTGCCCAAGATCTGATACAAGGTCGGGGTGTCT
ATGCAAAGGAAGCTCAGTTTTCTTTTATTATGAGCTGCTTGTTTGAGTGGTGTAAAACTATGTGCTCTTCAATATAGTGCTAAAGAAGCC
AGCTAATTTTATCAAAGCAGCAGCCAAAGAAGTCAGGACAAATCTTCAGGACTTGTGAAATGAACTGAAAGAGCTTGAAGCAGATGGAAT
TTTAATAGTTACACTATATATGCTCTTAGTAGGTTTTTTTCTTGTAGTGGAAACATAACTGTTAGCATATTTCTTAGGATGTTTTTTCTT
GTCTTTTTAAATTCTTATTTCACTCATCCTTTACTCTCCCCTCAAGTATTCTACACTTTAATTTCCTGAAATAAATTTAAGGAAAAGGGA
AATAGTAAAGAAGTAGGAATGGGTGCAGCACACCAGCATGGCACATGAATACACATGTAACTAACCTGCACATTGTGCACATGTACCCTA

>97297_97297_2_USP25-DZIP3_USP25_chr21_17163983_ENST00000285679_DZIP3_chr3_108392925_ENST00000463306_length(amino acids)=590AA_BP=245
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQVYFLQCRRDFGLLHLEQTEKECLNQ
LARVTHMAASNLESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILMQQFLGRPLVKESFFRP
ILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVPPSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSL
SELTFDEIVCKISQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDEEEEEEEPCVICHENLSPE

--------------------------------------------------------------
>97297_97297_3_USP25-DZIP3_USP25_chr21_17163983_ENST00000285681_DZIP3_chr3_108392925_ENST00000361582_length(transcript)=3455nt_BP=924nt
AAGCAGCCCGCGGACCGGCAGCAAAGGAACGTGCGAACGCGTGACGCCGCCCGACTGGCTCGCGCTCTCCCGTGCCCCGGCGTCCTCCGC
CCGCTCATGGCCCGGGCCGCCGCGGACGAGCGGCGCTGAGGCGGGCCGCGTGGAGACGTGAGGCGGCCGCCGTGGCCCTCACAGTCGGCG
TTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGCGGGGGCGCTGTCCTCCCAGGCCGTCCGC
GCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGGCGCCACCGCCGCCGCCGCCGCCGCCGCC
GCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCAGACGTTTTTGAATCAACTGAGAGAAATT
ACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGAATTAGCAGTGGCTTTCCTTACTGCGAAG
AATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGATAGATACATCAGTGTGGGAAGCCAAGCA
GATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTTGAGTTTGGCCGAATCAAACAGGGCATTC
AGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGCAGAGAATAAAGCATGTTTGAAGAGGACA
CCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCCCGTTGGGCTAAAGAATGTTGGCAATACT
TGTTGGTTTAGTGCTGTTATTCAGGTGTATTTCTTACAGTGTCGTAGGGATTTTGGTTTGCTTCATCTAGAGCAGACTGAAAAGGAATGT
CTCAATCAGCTTGCCAGGGTGACTCACATGGCAGCAAGCAACCTAGAATCACTTCAATTAAAGGCTGCGGTAGACAGTTGGAATGCCATT
GTGGCAGATGTTAGAAACAAGATTGCATTCCTCAGGACACAGTACAATGAACAAATAAACAAAGTCAAGCAAGGATTTGCCTTGAGTACC
TTGCCTCCAGTCCAGCTTCCTCCTCCACCACCCAGTCCTGAGATACTGATGCAGCAGTTCTTAGGAAGACCTCTTGTGAAAGAATCTTTC
TTTAGACCCATACTTACTGTTCCTCAAATGCCTGCAGTTTGCCCGGGAGTCGTCTCTGCAACTGGCCAACCTAGAGCCCCCCTGATGACT
GGCATAGCCTGGGCTCTGCCAGCGCCTGTGGGAGACGCTGTGCCTCCCAGTGCAGGTCTGCGGAGTGATCCCTCCATCATGAATTGGGAG
AGAATTACAGACAGGCTGAAAACTGCCTTTCCACAGCAAACCAGAAAGGAACTTACAGATTTCTTACGGAAATTGAAGGATGCTTATGGA
AAATCCTTGTCTGAACTGACATTTGATGAAATTGTTTGCAAGATTTCCCAGTTTATTGACCCCAAAAAGTCTCAGAGTCAAGGAAAATCA
GTGTCAAATGTTAATTGTGTTTCACCTAGTCATTCTCCATCACAGCCTGATGCTGCCCAGCCCCCAAAACCAGCCTGGAGGCCACTCACT
TCACAGGGTCCTGCCACATGGGAAGGAGCCAGTAATCCAGATGAGGAAGAGGAAGAAGAAGAGCCTTGTGTGATCTGTCATGAGAATCTG
TCTCCAGAAAATCTTTCAGTTTTGCCTTGCGCTCACAAATTCCATGCTCAGTGCATTAGACCATGGTTGATGCAACAGGGGACATGTCCA
ACGTGCAGACTCCACGTTTTGCTACCAGAAGAATTCCCTGGTCACCCCAGCCGGCAGTTGCCCAAGATCTGATACAAGGTACCCATGAAG
AGATTATGAACTACTTGAAGGTGGAGACTGTACGGTGGTGTGTTGGAGCTGGCTTGTAATGTCTTATGAGTGACAATCGTTAGTTTGAGG
AATTTTGTGAGACAGTTGTCAAATTGTTGCTAGCTTGAAATCTGCGGCAATTGGAGTATTTACACCATAGAAATGCTATAAGTGAAGACC
TACCTTTCCCTTAAGAGCTAGTTGTTAAACCTTTACCAGCATACCACTGGACCTTGTCTAAAATTTCTTTGTGTTCCCAGTGTCTTGCCC
AGTAGATACAAGATAAATATTGCCAGAATCAGATATCAGGAAGTAGTAAGAAAAGGAGTTAATATGCAAACTAAATCACTCGCTCAATTG
AATAATTGAGATCTTCTGTTCATTTGTTCCTTGGACCTTAATCATTTGCATTTTGGAGAAAATTTTTTCTGCTTTAAAAGTCTGTAATTT
CAGTTTTTGTGTCGGGGAGAGGGAAAAACTATTTGTCTGTAGTTGCTTTTTGTGACAAAGTGAATACCCACTGGGCTAAGTTTCATATCT
AAAGCTTGTCACTAAGAATTTTCATTTTTAGGGGTCAAAAACCTATTTTGAAAATAGTGTTGTGTGAATGCTGTAAGTGTTGTACATGTC
TCTGGTTTCAGAATTAAAAGAATTCAGAGTTACCTTGTGAGATAAATGTTCTTTGCTTCATATTCACAGTTTCACCTCCATTTAAATTTA
TGGGGAAGAATAAATGTTTCCTGACTCAGAAACAATTTTGCCTCCATATTTCAGTGCAAATATATTTTGAAGTTACTTTTAAATATTTAT
TTAAAACCTCTGTTTCTGTAACTGTATGTTAAACGTATTCTTCTGTAATGAGAATAGACTGGAACATGTGAGGGAAAAATATTTAAAAAA
AGATGGCAGTCATCTAGACATGTAAAATGCCAAGAATGTCTTAGAATTGCACAATTTAGAATTTATAGAGCCTTTAATCACCTTGTCTAG
CACCTTGTATTAGTCCATTTTCATGCTGCTGATAAAGACATACCTGAGATTGGGCAATTTACAAAAGAAAGAGGTTTAACGGACTTACAG
TTCCACATGACTAAGGAGGCCTCACAATCATGGTGGAAGGCAAAGAGGAGCAAGTCACATCTTACATGGATGGCAGCAGACAAGGAGAGA
GAGCTTGTGCAGGGAAACTCCCATTTTTAAAACCATCAGATCTCATGAGGCTTACTATCACGAGAACAGCATGGGAAAGACCTGCCCCCG
TGATTAAATTATTTCCCACCAGGCCCCTCCCACAACATGGAATAATGGGAGATACAAGATATTTGGGTGGAGACACAGAGCCAAACCATA
TCACACCTTAAGGTCATGGTCATATAGCTAGTTATCTTGTAAAACCAATGTTTCTTAGTTCATACTTACAACTGCAATTTCACTTTCATT

>97297_97297_3_USP25-DZIP3_USP25_chr21_17163983_ENST00000285681_DZIP3_chr3_108392925_ENST00000361582_length(amino acids)=590AA_BP=245
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQVYFLQCRRDFGLLHLEQTEKECLNQ
LARVTHMAASNLESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILMQQFLGRPLVKESFFRP
ILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVPPSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSL
SELTFDEIVCKISQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDEEEEEEEPCVICHENLSPE

--------------------------------------------------------------
>97297_97297_4_USP25-DZIP3_USP25_chr21_17163983_ENST00000285681_DZIP3_chr3_108392925_ENST00000463306_length(transcript)=2452nt_BP=924nt
AAGCAGCCCGCGGACCGGCAGCAAAGGAACGTGCGAACGCGTGACGCCGCCCGACTGGCTCGCGCTCTCCCGTGCCCCGGCGTCCTCCGC
CCGCTCATGGCCCGGGCCGCCGCGGACGAGCGGCGCTGAGGCGGGCCGCGTGGAGACGTGAGGCGGCCGCCGTGGCCCTCACAGTCGGCG
TTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGCGGGGGCGCTGTCCTCCCAGGCCGTCCGC
GCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGGCGCCACCGCCGCCGCCGCCGCCGCCGCC
GCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCAGACGTTTTTGAATCAACTGAGAGAAATT
ACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGAATTAGCAGTGGCTTTCCTTACTGCGAAG
AATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGATAGATACATCAGTGTGGGAAGCCAAGCA
GATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTTGAGTTTGGCCGAATCAAACAGGGCATTC
AGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGCAGAGAATAAAGCATGTTTGAAGAGGACA
CCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCCCGTTGGGCTAAAGAATGTTGGCAATACT
TGTTGGTTTAGTGCTGTTATTCAGGTGTATTTCTTACAGTGTCGTAGGGATTTTGGTTTGCTTCATCTAGAGCAGACTGAAAAGGAATGT
CTCAATCAGCTTGCCAGGGTGACTCACATGGCAGCAAGCAACCTAGAATCACTTCAATTAAAGGCTGCGGTAGACAGTTGGAATGCCATT
GTGGCAGATGTTAGAAACAAGATTGCATTCCTCAGGACACAGTACAATGAACAAATAAACAAAGTCAAGCAAGGATTTGCCTTGAGTACC
TTGCCTCCAGTCCAGCTTCCTCCTCCACCACCCAGTCCTGAGATACTGATGCAGCAGTTCTTAGGAAGACCTCTTGTGAAAGAATCTTTC
TTTAGACCCATACTTACTGTTCCTCAAATGCCTGCAGTTTGCCCGGGAGTCGTCTCTGCAACTGGCCAACCTAGAGCCCCCCTGATGACT
GGCATAGCCTGGGCTCTGCCAGCGCCTGTGGGAGACGCTGTGCCTCCCAGTGCAGGTCTGCGGAGTGATCCCTCCATCATGAATTGGGAG
AGAATTACAGACAGGCTGAAAACTGCCTTTCCACAGCAAACCAGAAAGGAACTTACAGATTTCTTACGGAAATTGAAGGATGCTTATGGA
AAATCCTTGTCTGAACTGACATTTGATGAAATTGTTTGCAAGATTTCCCAGTTTATTGACCCCAAAAAGTCTCAGAGTCAAGGAAAATCA
GTGTCAAATGTTAATTGTGTTTCACCTAGTCATTCTCCATCACAGCCTGATGCTGCCCAGCCCCCAAAACCAGCCTGGAGGCCACTCACT
TCACAGGGTCCTGCCACATGGGAAGGAGCCAGTAATCCAGATGAGGAAGAGGAAGAAGAAGAGCCTTGTGTGATCTGTCATGAGAATCTG
TCTCCAGAAAATCTTTCAGTTTTGCCTTGCGCTCACAAATTCCATGCTCAGTGCATTAGACCATGGTTGATGCAACAGGGGACATGTCCA
ACGTGCAGACTCCACGTTTTGCTACCAGAAGAATTCCCTGGTCACCCCAGCCGGCAGTTGCCCAAGATCTGATACAAGGTCGGGGTGTCT
ATGCAAAGGAAGCTCAGTTTTCTTTTATTATGAGCTGCTTGTTTGAGTGGTGTAAAACTATGTGCTCTTCAATATAGTGCTAAAGAAGCC
AGCTAATTTTATCAAAGCAGCAGCCAAAGAAGTCAGGACAAATCTTCAGGACTTGTGAAATGAACTGAAAGAGCTTGAAGCAGATGGAAT
TTTAATAGTTACACTATATATGCTCTTAGTAGGTTTTTTTCTTGTAGTGGAAACATAACTGTTAGCATATTTCTTAGGATGTTTTTTCTT
GTCTTTTTAAATTCTTATTTCACTCATCCTTTACTCTCCCCTCAAGTATTCTACACTTTAATTTCCTGAAATAAATTTAAGGAAAAGGGA
AATAGTAAAGAAGTAGGAATGGGTGCAGCACACCAGCATGGCACATGAATACACATGTAACTAACCTGCACATTGTGCACATGTACCCTA

>97297_97297_4_USP25-DZIP3_USP25_chr21_17163983_ENST00000285681_DZIP3_chr3_108392925_ENST00000463306_length(amino acids)=590AA_BP=245
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQVYFLQCRRDFGLLHLEQTEKECLNQ
LARVTHMAASNLESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILMQQFLGRPLVKESFFRP
ILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVPPSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSL
SELTFDEIVCKISQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDEEEEEEEPCVICHENLSPE

--------------------------------------------------------------
>97297_97297_5_USP25-DZIP3_USP25_chr21_17163983_ENST00000351097_DZIP3_chr3_108392925_ENST00000361582_length(transcript)=3455nt_BP=924nt
AAGCAGCCCGCGGACCGGCAGCAAAGGAACGTGCGAACGCGTGACGCCGCCCGACTGGCTCGCGCTCTCCCGTGCCCCGGCGTCCTCCGC
CCGCTCATGGCCCGGGCCGCCGCGGACGAGCGGCGCTGAGGCGGGCCGCGTGGAGACGTGAGGCGGCCGCCGTGGCCCTCACAGTCGGCG
TTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGCGGGGGCGCTGTCCTCCCAGGCCGTCCGC
GCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGGCGCCACCGCCGCCGCCGCCGCCGCCGCC
GCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCAGACGTTTTTGAATCAACTGAGAGAAATT
ACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGAATTAGCAGTGGCTTTCCTTACTGCGAAG
AATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGATAGATACATCAGTGTGGGAAGCCAAGCA
GATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTTGAGTTTGGCCGAATCAAACAGGGCATTC
AGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGCAGAGAATAAAGCATGTTTGAAGAGGACA
CCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCCCGTTGGGCTAAAGAATGTTGGCAATACT
TGTTGGTTTAGTGCTGTTATTCAGGTGTATTTCTTACAGTGTCGTAGGGATTTTGGTTTGCTTCATCTAGAGCAGACTGAAAAGGAATGT
CTCAATCAGCTTGCCAGGGTGACTCACATGGCAGCAAGCAACCTAGAATCACTTCAATTAAAGGCTGCGGTAGACAGTTGGAATGCCATT
GTGGCAGATGTTAGAAACAAGATTGCATTCCTCAGGACACAGTACAATGAACAAATAAACAAAGTCAAGCAAGGATTTGCCTTGAGTACC
TTGCCTCCAGTCCAGCTTCCTCCTCCACCACCCAGTCCTGAGATACTGATGCAGCAGTTCTTAGGAAGACCTCTTGTGAAAGAATCTTTC
TTTAGACCCATACTTACTGTTCCTCAAATGCCTGCAGTTTGCCCGGGAGTCGTCTCTGCAACTGGCCAACCTAGAGCCCCCCTGATGACT
GGCATAGCCTGGGCTCTGCCAGCGCCTGTGGGAGACGCTGTGCCTCCCAGTGCAGGTCTGCGGAGTGATCCCTCCATCATGAATTGGGAG
AGAATTACAGACAGGCTGAAAACTGCCTTTCCACAGCAAACCAGAAAGGAACTTACAGATTTCTTACGGAAATTGAAGGATGCTTATGGA
AAATCCTTGTCTGAACTGACATTTGATGAAATTGTTTGCAAGATTTCCCAGTTTATTGACCCCAAAAAGTCTCAGAGTCAAGGAAAATCA
GTGTCAAATGTTAATTGTGTTTCACCTAGTCATTCTCCATCACAGCCTGATGCTGCCCAGCCCCCAAAACCAGCCTGGAGGCCACTCACT
TCACAGGGTCCTGCCACATGGGAAGGAGCCAGTAATCCAGATGAGGAAGAGGAAGAAGAAGAGCCTTGTGTGATCTGTCATGAGAATCTG
TCTCCAGAAAATCTTTCAGTTTTGCCTTGCGCTCACAAATTCCATGCTCAGTGCATTAGACCATGGTTGATGCAACAGGGGACATGTCCA
ACGTGCAGACTCCACGTTTTGCTACCAGAAGAATTCCCTGGTCACCCCAGCCGGCAGTTGCCCAAGATCTGATACAAGGTACCCATGAAG
AGATTATGAACTACTTGAAGGTGGAGACTGTACGGTGGTGTGTTGGAGCTGGCTTGTAATGTCTTATGAGTGACAATCGTTAGTTTGAGG
AATTTTGTGAGACAGTTGTCAAATTGTTGCTAGCTTGAAATCTGCGGCAATTGGAGTATTTACACCATAGAAATGCTATAAGTGAAGACC
TACCTTTCCCTTAAGAGCTAGTTGTTAAACCTTTACCAGCATACCACTGGACCTTGTCTAAAATTTCTTTGTGTTCCCAGTGTCTTGCCC
AGTAGATACAAGATAAATATTGCCAGAATCAGATATCAGGAAGTAGTAAGAAAAGGAGTTAATATGCAAACTAAATCACTCGCTCAATTG
AATAATTGAGATCTTCTGTTCATTTGTTCCTTGGACCTTAATCATTTGCATTTTGGAGAAAATTTTTTCTGCTTTAAAAGTCTGTAATTT
CAGTTTTTGTGTCGGGGAGAGGGAAAAACTATTTGTCTGTAGTTGCTTTTTGTGACAAAGTGAATACCCACTGGGCTAAGTTTCATATCT
AAAGCTTGTCACTAAGAATTTTCATTTTTAGGGGTCAAAAACCTATTTTGAAAATAGTGTTGTGTGAATGCTGTAAGTGTTGTACATGTC
TCTGGTTTCAGAATTAAAAGAATTCAGAGTTACCTTGTGAGATAAATGTTCTTTGCTTCATATTCACAGTTTCACCTCCATTTAAATTTA
TGGGGAAGAATAAATGTTTCCTGACTCAGAAACAATTTTGCCTCCATATTTCAGTGCAAATATATTTTGAAGTTACTTTTAAATATTTAT
TTAAAACCTCTGTTTCTGTAACTGTATGTTAAACGTATTCTTCTGTAATGAGAATAGACTGGAACATGTGAGGGAAAAATATTTAAAAAA
AGATGGCAGTCATCTAGACATGTAAAATGCCAAGAATGTCTTAGAATTGCACAATTTAGAATTTATAGAGCCTTTAATCACCTTGTCTAG
CACCTTGTATTAGTCCATTTTCATGCTGCTGATAAAGACATACCTGAGATTGGGCAATTTACAAAAGAAAGAGGTTTAACGGACTTACAG
TTCCACATGACTAAGGAGGCCTCACAATCATGGTGGAAGGCAAAGAGGAGCAAGTCACATCTTACATGGATGGCAGCAGACAAGGAGAGA
GAGCTTGTGCAGGGAAACTCCCATTTTTAAAACCATCAGATCTCATGAGGCTTACTATCACGAGAACAGCATGGGAAAGACCTGCCCCCG
TGATTAAATTATTTCCCACCAGGCCCCTCCCACAACATGGAATAATGGGAGATACAAGATATTTGGGTGGAGACACAGAGCCAAACCATA
TCACACCTTAAGGTCATGGTCATATAGCTAGTTATCTTGTAAAACCAATGTTTCTTAGTTCATACTTACAACTGCAATTTCACTTTCATT

>97297_97297_5_USP25-DZIP3_USP25_chr21_17163983_ENST00000351097_DZIP3_chr3_108392925_ENST00000361582_length(amino acids)=590AA_BP=245
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQVYFLQCRRDFGLLHLEQTEKECLNQ
LARVTHMAASNLESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILMQQFLGRPLVKESFFRP
ILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVPPSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSL
SELTFDEIVCKISQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDEEEEEEEPCVICHENLSPE

--------------------------------------------------------------
>97297_97297_6_USP25-DZIP3_USP25_chr21_17163983_ENST00000351097_DZIP3_chr3_108392925_ENST00000463306_length(transcript)=2452nt_BP=924nt
AAGCAGCCCGCGGACCGGCAGCAAAGGAACGTGCGAACGCGTGACGCCGCCCGACTGGCTCGCGCTCTCCCGTGCCCCGGCGTCCTCCGC
CCGCTCATGGCCCGGGCCGCCGCGGACGAGCGGCGCTGAGGCGGGCCGCGTGGAGACGTGAGGCGGCCGCCGTGGCCCTCACAGTCGGCG
TTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGCGGGGGCGCTGTCCTCCCAGGCCGTCCGC
GCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGGCGCCACCGCCGCCGCCGCCGCCGCCGCC
GCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCAGACGTTTTTGAATCAACTGAGAGAAATT
ACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGAATTAGCAGTGGCTTTCCTTACTGCGAAG
AATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGATAGATACATCAGTGTGGGAAGCCAAGCA
GATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTTGAGTTTGGCCGAATCAAACAGGGCATTC
AGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGCAGAGAATAAAGCATGTTTGAAGAGGACA
CCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCCCGTTGGGCTAAAGAATGTTGGCAATACT
TGTTGGTTTAGTGCTGTTATTCAGGTGTATTTCTTACAGTGTCGTAGGGATTTTGGTTTGCTTCATCTAGAGCAGACTGAAAAGGAATGT
CTCAATCAGCTTGCCAGGGTGACTCACATGGCAGCAAGCAACCTAGAATCACTTCAATTAAAGGCTGCGGTAGACAGTTGGAATGCCATT
GTGGCAGATGTTAGAAACAAGATTGCATTCCTCAGGACACAGTACAATGAACAAATAAACAAAGTCAAGCAAGGATTTGCCTTGAGTACC
TTGCCTCCAGTCCAGCTTCCTCCTCCACCACCCAGTCCTGAGATACTGATGCAGCAGTTCTTAGGAAGACCTCTTGTGAAAGAATCTTTC
TTTAGACCCATACTTACTGTTCCTCAAATGCCTGCAGTTTGCCCGGGAGTCGTCTCTGCAACTGGCCAACCTAGAGCCCCCCTGATGACT
GGCATAGCCTGGGCTCTGCCAGCGCCTGTGGGAGACGCTGTGCCTCCCAGTGCAGGTCTGCGGAGTGATCCCTCCATCATGAATTGGGAG
AGAATTACAGACAGGCTGAAAACTGCCTTTCCACAGCAAACCAGAAAGGAACTTACAGATTTCTTACGGAAATTGAAGGATGCTTATGGA
AAATCCTTGTCTGAACTGACATTTGATGAAATTGTTTGCAAGATTTCCCAGTTTATTGACCCCAAAAAGTCTCAGAGTCAAGGAAAATCA
GTGTCAAATGTTAATTGTGTTTCACCTAGTCATTCTCCATCACAGCCTGATGCTGCCCAGCCCCCAAAACCAGCCTGGAGGCCACTCACT
TCACAGGGTCCTGCCACATGGGAAGGAGCCAGTAATCCAGATGAGGAAGAGGAAGAAGAAGAGCCTTGTGTGATCTGTCATGAGAATCTG
TCTCCAGAAAATCTTTCAGTTTTGCCTTGCGCTCACAAATTCCATGCTCAGTGCATTAGACCATGGTTGATGCAACAGGGGACATGTCCA
ACGTGCAGACTCCACGTTTTGCTACCAGAAGAATTCCCTGGTCACCCCAGCCGGCAGTTGCCCAAGATCTGATACAAGGTCGGGGTGTCT
ATGCAAAGGAAGCTCAGTTTTCTTTTATTATGAGCTGCTTGTTTGAGTGGTGTAAAACTATGTGCTCTTCAATATAGTGCTAAAGAAGCC
AGCTAATTTTATCAAAGCAGCAGCCAAAGAAGTCAGGACAAATCTTCAGGACTTGTGAAATGAACTGAAAGAGCTTGAAGCAGATGGAAT
TTTAATAGTTACACTATATATGCTCTTAGTAGGTTTTTTTCTTGTAGTGGAAACATAACTGTTAGCATATTTCTTAGGATGTTTTTTCTT
GTCTTTTTAAATTCTTATTTCACTCATCCTTTACTCTCCCCTCAAGTATTCTACACTTTAATTTCCTGAAATAAATTTAAGGAAAAGGGA
AATAGTAAAGAAGTAGGAATGGGTGCAGCACACCAGCATGGCACATGAATACACATGTAACTAACCTGCACATTGTGCACATGTACCCTA

>97297_97297_6_USP25-DZIP3_USP25_chr21_17163983_ENST00000351097_DZIP3_chr3_108392925_ENST00000463306_length(amino acids)=590AA_BP=245
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQVYFLQCRRDFGLLHLEQTEKECLNQ
LARVTHMAASNLESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILMQQFLGRPLVKESFFRP
ILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVPPSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSL
SELTFDEIVCKISQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDEEEEEEEPCVICHENLSPE

--------------------------------------------------------------
>97297_97297_7_USP25-DZIP3_USP25_chr21_17163983_ENST00000400183_DZIP3_chr3_108392925_ENST00000361582_length(transcript)=3303nt_BP=772nt
GCGGCCGCCGTGGCCCTCACAGTCGGCGTTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGC
GGGGGCGCTGTCCTCCCAGGCCGTCCGCGCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGG
CGCCACCGCCGCCGCCGCCGCCGCCGCCGCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCA
GACGTTTTTGAATCAACTGAGAGAAATTACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGA
ATTAGCAGTGGCTTTCCTTACTGCGAAGAATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGA
TAGATACATCAGTGTGGGAAGCCAAGCAGATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTT
GAGTTTGGCCGAATCAAACAGGGCATTCAGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGC
AGAGAATAAAGCATGTTTGAAGAGGACACCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCC
CGTTGGGCTAAAGAATGTTGGCAATACTTGTTGGTTTAGTGCTGTTATTCAGGTGTATTTCTTACAGTGTCGTAGGGATTTTGGTTTGCT
TCATCTAGAGCAGACTGAAAAGGAATGTCTCAATCAGCTTGCCAGGGTGACTCACATGGCAGCAAGCAACCTAGAATCACTTCAATTAAA
GGCTGCGGTAGACAGTTGGAATGCCATTGTGGCAGATGTTAGAAACAAGATTGCATTCCTCAGGACACAGTACAATGAACAAATAAACAA
AGTCAAGCAAGGATTTGCCTTGAGTACCTTGCCTCCAGTCCAGCTTCCTCCTCCACCACCCAGTCCTGAGATACTGATGCAGCAGTTCTT
AGGAAGACCTCTTGTGAAAGAATCTTTCTTTAGACCCATACTTACTGTTCCTCAAATGCCTGCAGTTTGCCCGGGAGTCGTCTCTGCAAC
TGGCCAACCTAGAGCCCCCCTGATGACTGGCATAGCCTGGGCTCTGCCAGCGCCTGTGGGAGACGCTGTGCCTCCCAGTGCAGGTCTGCG
GAGTGATCCCTCCATCATGAATTGGGAGAGAATTACAGACAGGCTGAAAACTGCCTTTCCACAGCAAACCAGAAAGGAACTTACAGATTT
CTTACGGAAATTGAAGGATGCTTATGGAAAATCCTTGTCTGAACTGACATTTGATGAAATTGTTTGCAAGATTTCCCAGTTTATTGACCC
CAAAAAGTCTCAGAGTCAAGGAAAATCAGTGTCAAATGTTAATTGTGTTTCACCTAGTCATTCTCCATCACAGCCTGATGCTGCCCAGCC
CCCAAAACCAGCCTGGAGGCCACTCACTTCACAGGGTCCTGCCACATGGGAAGGAGCCAGTAATCCAGATGAGGAAGAGGAAGAAGAAGA
GCCTTGTGTGATCTGTCATGAGAATCTGTCTCCAGAAAATCTTTCAGTTTTGCCTTGCGCTCACAAATTCCATGCTCAGTGCATTAGACC
ATGGTTGATGCAACAGGGGACATGTCCAACGTGCAGACTCCACGTTTTGCTACCAGAAGAATTCCCTGGTCACCCCAGCCGGCAGTTGCC
CAAGATCTGATACAAGGTACCCATGAAGAGATTATGAACTACTTGAAGGTGGAGACTGTACGGTGGTGTGTTGGAGCTGGCTTGTAATGT
CTTATGAGTGACAATCGTTAGTTTGAGGAATTTTGTGAGACAGTTGTCAAATTGTTGCTAGCTTGAAATCTGCGGCAATTGGAGTATTTA
CACCATAGAAATGCTATAAGTGAAGACCTACCTTTCCCTTAAGAGCTAGTTGTTAAACCTTTACCAGCATACCACTGGACCTTGTCTAAA
ATTTCTTTGTGTTCCCAGTGTCTTGCCCAGTAGATACAAGATAAATATTGCCAGAATCAGATATCAGGAAGTAGTAAGAAAAGGAGTTAA
TATGCAAACTAAATCACTCGCTCAATTGAATAATTGAGATCTTCTGTTCATTTGTTCCTTGGACCTTAATCATTTGCATTTTGGAGAAAA
TTTTTTCTGCTTTAAAAGTCTGTAATTTCAGTTTTTGTGTCGGGGAGAGGGAAAAACTATTTGTCTGTAGTTGCTTTTTGTGACAAAGTG
AATACCCACTGGGCTAAGTTTCATATCTAAAGCTTGTCACTAAGAATTTTCATTTTTAGGGGTCAAAAACCTATTTTGAAAATAGTGTTG
TGTGAATGCTGTAAGTGTTGTACATGTCTCTGGTTTCAGAATTAAAAGAATTCAGAGTTACCTTGTGAGATAAATGTTCTTTGCTTCATA
TTCACAGTTTCACCTCCATTTAAATTTATGGGGAAGAATAAATGTTTCCTGACTCAGAAACAATTTTGCCTCCATATTTCAGTGCAAATA
TATTTTGAAGTTACTTTTAAATATTTATTTAAAACCTCTGTTTCTGTAACTGTATGTTAAACGTATTCTTCTGTAATGAGAATAGACTGG
AACATGTGAGGGAAAAATATTTAAAAAAAGATGGCAGTCATCTAGACATGTAAAATGCCAAGAATGTCTTAGAATTGCACAATTTAGAAT
TTATAGAGCCTTTAATCACCTTGTCTAGCACCTTGTATTAGTCCATTTTCATGCTGCTGATAAAGACATACCTGAGATTGGGCAATTTAC
AAAAGAAAGAGGTTTAACGGACTTACAGTTCCACATGACTAAGGAGGCCTCACAATCATGGTGGAAGGCAAAGAGGAGCAAGTCACATCT
TACATGGATGGCAGCAGACAAGGAGAGAGAGCTTGTGCAGGGAAACTCCCATTTTTAAAACCATCAGATCTCATGAGGCTTACTATCACG
AGAACAGCATGGGAAAGACCTGCCCCCGTGATTAAATTATTTCCCACCAGGCCCCTCCCACAACATGGAATAATGGGAGATACAAGATAT
TTGGGTGGAGACACAGAGCCAAACCATATCACACCTTAAGGTCATGGTCATATAGCTAGTTATCTTGTAAAACCAATGTTTCTTAGTTCA

>97297_97297_7_USP25-DZIP3_USP25_chr21_17163983_ENST00000400183_DZIP3_chr3_108392925_ENST00000361582_length(amino acids)=590AA_BP=245
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQVYFLQCRRDFGLLHLEQTEKECLNQ
LARVTHMAASNLESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILMQQFLGRPLVKESFFRP
ILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVPPSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSL
SELTFDEIVCKISQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDEEEEEEEPCVICHENLSPE

--------------------------------------------------------------
>97297_97297_8_USP25-DZIP3_USP25_chr21_17163983_ENST00000400183_DZIP3_chr3_108392925_ENST00000463306_length(transcript)=2300nt_BP=772nt
GCGGCCGCCGTGGCCCTCACAGTCGGCGTTTCGCCGCCTGCCCGCGGTGCCCGCGCACGCCGGCCGCCATCGCCTTCGCGCCTGGCTGGC
GGGGGCGCTGTCCTCCCAGGCCGTCCGCGCCGCTCCCTGGAGCTCGGCGGAGCGCGGCAGCCAGGGCCGGCGGAGGCGCGAGGAGCCGGG
CGCCACCGCCGCCGCCGCCGCCGCCGCCGCGGGGGCCATGACCGTGGAGCAGAACGTGCTGCAGCAGAGCGCGGCGCAGAAGCACCAGCA
GACGTTTTTGAATCAACTGAGAGAAATTACGGGGATTAATGACACCCAGATACTACAGCAAGCCTTGAAGGATAGTAATGGAAACTTGGA
ATTAGCAGTGGCTTTCCTTACTGCGAAGAATGCTAAGACCCCTCAGCAGGAGGAGACAACTTACTACCAAACAGCACTTCCTGGCAATGA
TAGATACATCAGTGTGGGAAGCCAAGCAGATACAAATGTGATTGATCTCACTGGAGATGATAAAGATGATCTTCAGAGAGCAATTGCCTT
GAGTTTGGCCGAATCAAACAGGGCATTCAGGGAGACTGGAATAACTGATGAGGAACAAGCCATTAGCAGAGTTCTTGAAGCCAGCATAGC
AGAGAATAAAGCATGTTTGAAGAGGACACCTACAGAAGTTTGGAGGGATTCTCGAAACCCTTATGATAGAAAAAGACAGGACAAAGCTCC
CGTTGGGCTAAAGAATGTTGGCAATACTTGTTGGTTTAGTGCTGTTATTCAGGTGTATTTCTTACAGTGTCGTAGGGATTTTGGTTTGCT
TCATCTAGAGCAGACTGAAAAGGAATGTCTCAATCAGCTTGCCAGGGTGACTCACATGGCAGCAAGCAACCTAGAATCACTTCAATTAAA
GGCTGCGGTAGACAGTTGGAATGCCATTGTGGCAGATGTTAGAAACAAGATTGCATTCCTCAGGACACAGTACAATGAACAAATAAACAA
AGTCAAGCAAGGATTTGCCTTGAGTACCTTGCCTCCAGTCCAGCTTCCTCCTCCACCACCCAGTCCTGAGATACTGATGCAGCAGTTCTT
AGGAAGACCTCTTGTGAAAGAATCTTTCTTTAGACCCATACTTACTGTTCCTCAAATGCCTGCAGTTTGCCCGGGAGTCGTCTCTGCAAC
TGGCCAACCTAGAGCCCCCCTGATGACTGGCATAGCCTGGGCTCTGCCAGCGCCTGTGGGAGACGCTGTGCCTCCCAGTGCAGGTCTGCG
GAGTGATCCCTCCATCATGAATTGGGAGAGAATTACAGACAGGCTGAAAACTGCCTTTCCACAGCAAACCAGAAAGGAACTTACAGATTT
CTTACGGAAATTGAAGGATGCTTATGGAAAATCCTTGTCTGAACTGACATTTGATGAAATTGTTTGCAAGATTTCCCAGTTTATTGACCC
CAAAAAGTCTCAGAGTCAAGGAAAATCAGTGTCAAATGTTAATTGTGTTTCACCTAGTCATTCTCCATCACAGCCTGATGCTGCCCAGCC
CCCAAAACCAGCCTGGAGGCCACTCACTTCACAGGGTCCTGCCACATGGGAAGGAGCCAGTAATCCAGATGAGGAAGAGGAAGAAGAAGA
GCCTTGTGTGATCTGTCATGAGAATCTGTCTCCAGAAAATCTTTCAGTTTTGCCTTGCGCTCACAAATTCCATGCTCAGTGCATTAGACC
ATGGTTGATGCAACAGGGGACATGTCCAACGTGCAGACTCCACGTTTTGCTACCAGAAGAATTCCCTGGTCACCCCAGCCGGCAGTTGCC
CAAGATCTGATACAAGGTCGGGGTGTCTATGCAAAGGAAGCTCAGTTTTCTTTTATTATGAGCTGCTTGTTTGAGTGGTGTAAAACTATG
TGCTCTTCAATATAGTGCTAAAGAAGCCAGCTAATTTTATCAAAGCAGCAGCCAAAGAAGTCAGGACAAATCTTCAGGACTTGTGAAATG
AACTGAAAGAGCTTGAAGCAGATGGAATTTTAATAGTTACACTATATATGCTCTTAGTAGGTTTTTTTCTTGTAGTGGAAACATAACTGT
TAGCATATTTCTTAGGATGTTTTTTCTTGTCTTTTTAAATTCTTATTTCACTCATCCTTTACTCTCCCCTCAAGTATTCTACACTTTAAT
TTCCTGAAATAAATTTAAGGAAAAGGGAAATAGTAAAGAAGTAGGAATGGGTGCAGCACACCAGCATGGCACATGAATACACATGTAACT

>97297_97297_8_USP25-DZIP3_USP25_chr21_17163983_ENST00000400183_DZIP3_chr3_108392925_ENST00000463306_length(amino acids)=590AA_BP=245
MPAVPAHAGRHRLRAWLAGALSSQAVRAAPWSSAERGSQGRRRREEPGATAAAAAAAAGAMTVEQNVLQQSAAQKHQQTFLNQLREITGI
NDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQVYFLQCRRDFGLLHLEQTEKECLNQ
LARVTHMAASNLESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILMQQFLGRPLVKESFFRP
ILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVPPSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSL
SELTFDEIVCKISQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDEEEEEEEPCVICHENLSPE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USP25-DZIP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP25-DZIP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP25-DZIP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource