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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:USP31-ERI2 (FusionGDB2 ID:97326)

Fusion Gene Summary for USP31-ERI2

Fusion gene summary

Fusion gene information	Fusion gene name: USP31-ERI2
	Fusion gene ID: 97326
		Hgene	Tgene
	Gene symbol	USP31	ERI2
	Gene ID	84196	112479
	Gene name	ubiquitin specific peptidase 48	ERI1 exoribonuclease family member 2
	Synonyms	RAP1GA1\|USP31	EXOD1\|ZGRF5
	Cytomap	1p36.12	16p12.3
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin carboxyl-terminal hydrolase 48deubiquitinating enzyme 48ubiquitin specific protease 31ubiquitin thioesterase 48ubiquitin thiolesterase 48ubiquitin-specific-processing protease 48	ERI1 exoribonuclease 2enhanced RNAi three prime mRNA exonuclease homolog 2exonuclease domain containing 1exonuclease domain-containing protein 1exoribonuclease 2zinc finger, GRF-type containing 5
	Modification date	20200313	20200313
	UniProtAcc	.	A8K979
	Ensembl transtripts involved in fusion gene	ENST00000219689, ENST00000567975,	ENST00000389345, ENST00000563117, ENST00000568251, ENST00000300005, ENST00000357967, ENST00000564349, ENST00000569729,
Fusion gene scores	* DoF score	15 X 9 X 6=810	2 X 2 X 2=8
	# samples	15	2
	** MAII score	log2(15/810*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: USP31 [Title/Abstract] AND ERI2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	USP31(23113640)-ERI2(20811724), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across USP31 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ERI2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HI-7168-01A	USP31	chr16	23113640	-	ERI2	chr16	20811724	-

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Fusion Gene ORF analysis for USP31-ERI2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000219689	ENST00000389345	USP31	chr16	23113640	-	ERI2	chr16	20811724	-
5CDS-intron	ENST00000219689	ENST00000563117	USP31	chr16	23113640	-	ERI2	chr16	20811724	-
5CDS-intron	ENST00000219689	ENST00000568251	USP31	chr16	23113640	-	ERI2	chr16	20811724	-
In-frame	ENST00000219689	ENST00000300005	USP31	chr16	23113640	-	ERI2	chr16	20811724	-
In-frame	ENST00000219689	ENST00000357967	USP31	chr16	23113640	-	ERI2	chr16	20811724	-
In-frame	ENST00000219689	ENST00000564349	USP31	chr16	23113640	-	ERI2	chr16	20811724	-
In-frame	ENST00000219689	ENST00000569729	USP31	chr16	23113640	-	ERI2	chr16	20811724	-
intron-3CDS	ENST00000567975	ENST00000300005	USP31	chr16	23113640	-	ERI2	chr16	20811724	-
intron-3CDS	ENST00000567975	ENST00000357967	USP31	chr16	23113640	-	ERI2	chr16	20811724	-
intron-3CDS	ENST00000567975	ENST00000564349	USP31	chr16	23113640	-	ERI2	chr16	20811724	-
intron-3CDS	ENST00000567975	ENST00000569729	USP31	chr16	23113640	-	ERI2	chr16	20811724	-
intron-intron	ENST00000567975	ENST00000389345	USP31	chr16	23113640	-	ERI2	chr16	20811724	-
intron-intron	ENST00000567975	ENST00000563117	USP31	chr16	23113640	-	ERI2	chr16	20811724	-
intron-intron	ENST00000567975	ENST00000568251	USP31	chr16	23113640	-	ERI2	chr16	20811724	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000219689	USP31	chr16	23113640	-	ENST00000564349	ERI2	chr16	20811724	-	4234	1234	0	2849	949
ENST00000219689	USP31	chr16	23113640	-	ENST00000300005	ERI2	chr16	20811724	-	2210	1234	0	1760	586
ENST00000219689	USP31	chr16	23113640	-	ENST00000357967	ERI2	chr16	20811724	-	4230	1234	0	2849	949
ENST00000219689	USP31	chr16	23113640	-	ENST00000569729	ERI2	chr16	20811724	-	3374	1234	0	1613	537

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000219689	ENST00000564349	USP31	chr16	23113640	-	ERI2	chr16	20811724	-	0.000138487	0.9998615
ENST00000219689	ENST00000300005	USP31	chr16	23113640	-	ERI2	chr16	20811724	-	0.013828768	0.9861712
ENST00000219689	ENST00000357967	USP31	chr16	23113640	-	ERI2	chr16	20811724	-	0.000138773	0.99986124
ENST00000219689	ENST00000569729	USP31	chr16	23113640	-	ERI2	chr16	20811724	-	0.003187059	0.996813

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Fusion Genomic Features for USP31-ERI2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP31-ERI2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:23113640/chr16:20811724)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ERI2 A8K979
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

USP31

chr16:23113640

chr16:20811724

ENST00000219689

95_125

411

1353.0

Compositional bias

Note=Pro-rich

Tgene

ERI2

chr16:23113640

chr16:20811724

ENST00000389345

37_226

427.0

Domain

Note=Exonuclease

Tgene

ERI2

chr16:23113640

chr16:20811724

ENST00000300005

595_642

153

329.0

Zinc finger

Note=GRF-type

Tgene

ERI2

chr16:23113640

chr16:20811724

ENST00000357967

595_642

153

692.0

Zinc finger

Note=GRF-type

Tgene

ERI2

chr16:23113640

chr16:20811724

ENST00000389345

595_642

427.0

Zinc finger

Note=GRF-type

Tgene

ERI2

chr16:23113640

chr16:20811724

ENST00000563117

595_642

599.0

Zinc finger

Note=GRF-type

Tgene

ERI2

chr16:23113640

chr16:20811724

ENST00000564349

595_642

599.0

Zinc finger

Note=GRF-type

Tgene

ERI2

chr16:23113640

chr16:20811724

ENST00000569729

595_642

153

280.0

Zinc finger

Note=GRF-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

USP31

chr16:23113640

chr16:20811724

ENST00000219689

770_1221

411

1353.0

Compositional bias

Note=Ser-rich

Hgene

USP31

chr16:23113640

chr16:20811724

ENST00000219689

128_765

411

1353.0

Domain

Note=USP

Tgene

ERI2

chr16:23113640

chr16:20811724

ENST00000300005

37_226

153

329.0

Domain

Note=Exonuclease

Tgene

ERI2

chr16:23113640

chr16:20811724

ENST00000357967

37_226

153

692.0

Domain

Note=Exonuclease

Tgene

ERI2

chr16:23113640

chr16:20811724

ENST00000563117

37_226

599.0

Domain

Note=Exonuclease

Tgene

ERI2

chr16:23113640

chr16:20811724

ENST00000564349

37_226

599.0

Domain

Note=Exonuclease

Tgene

ERI2

chr16:23113640

chr16:20811724

ENST00000569729

37_226

153

280.0

Domain

Note=Exonuclease

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Fusion Gene Sequence for USP31-ERI2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>97326_97326_1_USP31-ERI2_USP31_chr16_23113640_ENST00000219689_ERI2_chr16_20811724_ENST00000300005_length(transcript)=2210nt_BP=1234nt
ATGTCCAAGGTAACGGCGCCTGGGTCCGGGCCGCCGGCGGCGGCGAGCGGGAAGGAGAAGCGCTCCTTCAGCAAGCGGCTGTTTCGGAGC
GGCCGCGCTGGCGGCGGCGGCGCGGGGGGCCCCGGGGCGTCCGGGCCGGCCGCGCCTTCCTCGCCCTCCTCGCCCTCCTCTGCACGCTCG
GTGGGCAGCTTCATGAGCCGCGTTCTCAAGACGCTGTCCACGCTCTCGCACCTTAGCTCTGAGGGCGCCGCCCCAGACCGCGGCGGCCTC
CGCAGCTGCTTCCCGCCCGGGCCGGCCGCCGCGCCCACGCCGCCGCCGTGCCCGCCGCCGCCCGCCTCTCCCGCGCCGCCCGCTTGCGCC
GCCGAGCCGGTGCCCGGCGTGGCGGGGCTCCGCAACCACGGCAACACGTGCTTCATGAACGCCACGCTGCAGTGCCTCAGCAACACCGAG
CTCTTCGCCGAGTACCTGGCGCTGGGCCAGTACCGGGCGGGGCGGCCCGAGCCCTCGCCTGACCCGGAGCAGCCTGCGGGCCGCGGCGCG
CAGGGCCAGGGCGAGGTCACTGAGCAGCTGGCGCACCTGGTGCGGGCCCTCTGGACCCTGGAGTACACCCCGCAGCACAGCCGCGACTTC
AAGACTATTGTGTCAAAGAATGCACTGCAGTACCGGGGAAATTCCCAACATGATGCCCAGGAGTTTCTGCTGTGGCTTTTGGACCGAGTT
CATGAAGACCTCAACCATTCAGTGAAGCAGAGTGGCCAGCCTCCTCTGAAGCCACCATCAGAGACTGATATGATGCCTGAGGGACCATCT
TTCCCTGTCTGTAGCACTTTTGTACAAGAACTCTTTCAAGCGCAATACAGATCTTCTTTGACGTGTCCTCATTGTCAGAAACAGAGCAAC
ACTTTTGATCCTTTCCTTTGCATTTCTTTGCCAATTCCTCTGCCCCACACAAGGCCTCTCTATGTCACTGTAGTGTATCAAGGCAAATGT
TCTCACTGCATGAGGATTGGTGTGGCCGTACCTCTGTCTGGGACTGTCGCCAGACTTCGGGAAGCAGTGTCTATGGAAACAAAGATCCCC
ACTGATCAGATTGTGTTAACAGAAATGTACTATGATGGGTTCCATCGTTCCTTTTGTGATACAGACGACCTGGAAACAGTCCATGAAAGC
GACTGCATTTTTGCCTTTGAGACTCCCGAAATATTTAGGCCTGAAGGAATTCTCAGTCAAAGAGACTGGGACTTGGGGGTTTGCCTGGAG
TATGAGTGTAAAAGAAAGCAGCTGTTAAAACCTGTGTTTTTAAATTCTTGGATTGATCTCAGAGCAACTTACAAGCTTTTCTATAGGAGA
AAACCAAAAGGACTAAGTGGTGCCTTGCAGGAAGTAGGAATAGAATTCTCAGGACGAGAACATTCTGGGTTGGACGATTCTCGGAATACT
GCCCTTCTTGCTTGGAAAATGATCAGAGATGGTTGTGTAATGAAAATTACAAGGTCGTTGAACAAGGGTCCCTTCCTCTTGCCTTCGTGG
ACCTGGAACAGTGATCTGGCCTCAGGGGACCAGCATGCTTTTCTTCAGCAAGAATTTGGCTGTGGAACCTACAGAACCTTACTTCAGAAG
CCCAATATGAGTAAACAGGAAAAGGGGAATATTCTCTGGTTGACAATGGTGTGGCTGTCACTGGCATGTCTGCAAAGGAAAAACTACAAT
GACTGCATGTTAAACACAGCATCACAGACTGTTACCACTGAAAAATTTTGAGAAGCTCTCCACTTGAACCTCTTCATGTCATGAATCAGG
TGCCAGTGGCTTAGCTTGAATTACAGGGTAAAAGCCATCACTTTCTCTATCCTTTTAGGTGCTTTCTAGAATCAAAACTAAACTTTGTCA
TCAAAGGCCCATTTATAATAGCTGCTTTCCTAGCTTTTTATTCTATGATAAAGAAGGATTGAAGCATTTTTAAAACTTGAGATTTTTATC
ATACCTCCAGCAGAGTAAGGAGTCTGTGTGATCTTGCAATCATGGATAAGGAAGAATTTTCCCCTTCCCTCCCCTATGGATGCTTTAAAA
TGTGATTTTTTAAAAATGAGTATGTTAATACAATACATGTTAGTAAAAGCCATGGGTACTGATGGGCCAACACACTACAGCCTACTGGCA

>97326_97326_1_USP31-ERI2_USP31_chr16_23113640_ENST00000219689_ERI2_chr16_20811724_ENST00000300005_length(amino acids)=586AA_BP=0
MSKVTAPGSGPPAAASGKEKRSFSKRLFRSGRAGGGGAGGPGASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGL
RSCFPPGPAAAPTPPPCPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGA
QGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMMPEGPS
FPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIP
TDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETPEIFRPEGILSQRDWDLGVCLEYECKRKQLLKPVFLNSWIDLRATYKLFYRR
KPKGLSGALQEVGIEFSGREHSGLDDSRNTALLAWKMIRDGCVMKITRSLNKGPFLLPSWTWNSDLASGDQHAFLQQEFGCGTYRTLLQK

--------------------------------------------------------------
>97326_97326_2_USP31-ERI2_USP31_chr16_23113640_ENST00000219689_ERI2_chr16_20811724_ENST00000357967_length(transcript)=4230nt_BP=1234nt
ATGTCCAAGGTAACGGCGCCTGGGTCCGGGCCGCCGGCGGCGGCGAGCGGGAAGGAGAAGCGCTCCTTCAGCAAGCGGCTGTTTCGGAGC
GGCCGCGCTGGCGGCGGCGGCGCGGGGGGCCCCGGGGCGTCCGGGCCGGCCGCGCCTTCCTCGCCCTCCTCGCCCTCCTCTGCACGCTCG
GTGGGCAGCTTCATGAGCCGCGTTCTCAAGACGCTGTCCACGCTCTCGCACCTTAGCTCTGAGGGCGCCGCCCCAGACCGCGGCGGCCTC
CGCAGCTGCTTCCCGCCCGGGCCGGCCGCCGCGCCCACGCCGCCGCCGTGCCCGCCGCCGCCCGCCTCTCCCGCGCCGCCCGCTTGCGCC
GCCGAGCCGGTGCCCGGCGTGGCGGGGCTCCGCAACCACGGCAACACGTGCTTCATGAACGCCACGCTGCAGTGCCTCAGCAACACCGAG
CTCTTCGCCGAGTACCTGGCGCTGGGCCAGTACCGGGCGGGGCGGCCCGAGCCCTCGCCTGACCCGGAGCAGCCTGCGGGCCGCGGCGCG
CAGGGCCAGGGCGAGGTCACTGAGCAGCTGGCGCACCTGGTGCGGGCCCTCTGGACCCTGGAGTACACCCCGCAGCACAGCCGCGACTTC
AAGACTATTGTGTCAAAGAATGCACTGCAGTACCGGGGAAATTCCCAACATGATGCCCAGGAGTTTCTGCTGTGGCTTTTGGACCGAGTT
CATGAAGACCTCAACCATTCAGTGAAGCAGAGTGGCCAGCCTCCTCTGAAGCCACCATCAGAGACTGATATGATGCCTGAGGGACCATCT
TTCCCTGTCTGTAGCACTTTTGTACAAGAACTCTTTCAAGCGCAATACAGATCTTCTTTGACGTGTCCTCATTGTCAGAAACAGAGCAAC
ACTTTTGATCCTTTCCTTTGCATTTCTTTGCCAATTCCTCTGCCCCACACAAGGCCTCTCTATGTCACTGTAGTGTATCAAGGCAAATGT
TCTCACTGCATGAGGATTGGTGTGGCCGTACCTCTGTCTGGGACTGTCGCCAGACTTCGGGAAGCAGTGTCTATGGAAACAAAGATCCCC
ACTGATCAGATTGTGTTAACAGAAATGTACTATGATGGGTTCCATCGTTCCTTTTGTGATACAGACGACCTGGAAACAGTCCATGAAAGC
GACTGCATTTTTGCCTTTGAGACTCCCGAAATATTTAGGCCTGAAGGAATTCTCAGTCAAAGAGACTGGGACTTGGGGGTTTGCCTGGAG
TATGAGTGTAAAAGAAAGCAGCTGTTAAAACCTGTGTTTTTAAATTCTTGGATTGATCTCAGAGCAACTTACAAGCTTTTCTATAGGAGA
AAACCAAAAGGACTAAGTGGTGCCTTGCAGGAAGTAGGAATAGAATTCTCAGGACGAGAACATTCTGGGTTGGACGATTCTCGGAATACT
GCCCTTCTTGCTTGGAAAATGATCAGAGATGGTTGTGTAATGAAAATTACAAGGTCGTTGAACAAGGTTCCCACTAAGAAGAATTTCAGC
ATTCTGGCCAGAAATTTGAATACAATTCAAGTTGAAGAAATGTCTGCCTGTAACATTAGCATCCAGGGTCCCAGCATATATAATAAGGAG
CCTAAAAATATAATAAATCCTCATGAAAAAGTTCAAATGAAGTCAATTTGTGCAAATTCTCCTATAAAGGCACAACAGGATCAATTACAA
GTAAAAAACAATATAAAAGCAAGTCTTCACAATGTCAAAAGTTCCTTACCTCTTTTTAATACTAAGTCCTCTACTTCTGTGGGGCAGTTG
CAGTCTCCTACCTTGAATTCACCTATCTATATGCAAAAGCAAGGAAAAAATGAACATCTTGCATTTAATACCAAATCTAAGGCTTCAACA
GTTGGTTCAGAATTGGTACTTGTTTCTACCACCGTTCCAACTGTTCATCATGTTTCTGATTTGGAAATGAGCTCTACTCTGGACTGTTTA
CCTGTGTTGGCTGATTGGGAGGATGTGGTTTTACTGCCAGCATCTCAGCCTGAGGAAAACGTAGACTGTACAGTTCCCATTAGTGACTCA
GACTTAGAGATTTCATTTAATTCTGGAGAAAGATTAATGGTTTTGAAAGAATTGGAAATGTCAAGTCATGAAAACTTTGGAGACATAGAG
GAAACTCCTCAAAAATCTGAGACTTCTAAGTCTATTGTGTACAAGAGTCCTCACACTACTATTTATAATGTAAAAGAAGCCAAAGATCCA
GGTTCAGATATTTCTGCCTTTAAGTTACCTGAACACAAATCAAGTACCTTCAACAGAGTTAATGCCAATATGTCTCATCCTTTAGTTTTG
GGGAAACATCCTCTTCTTTCAGGTGGTACCAAAAGGAATCCATGCAGTCCCCAAGCTTTCCCACCAGCAAAAAAACAACCCTTCACTATT
CATGAAGAAAAGCCTACATCATCTGATTGCTCCCCAGTAAGAAGTTCTTCCTGGAGGCGTCTCCCATCTATATTAACTTCTACAGTTAAC
CTACAAGAGCCATGGAAGAGTGGGAAAATGACACCTCCATTATGCAAGTGTGGTCGGAGATCTAAGAGACTTGTTGTTTCTAATAATGGA
CCGAACCATGGAAAAGTCTTCTATTGTTGCCCTATCGGGAAATACCAAGAAAACAGAAAATGTTGTGGTTATTTCAAATGGGAACAAACA
CTTCAAAAGGAAAGAGCCAACAGCATGGTTCCATCTCATTCCACAGGGGGACTCACTTTTAGTTCTCCAGAAACAAGCCATATTTGTGAC
AGAAATTTAAGTATTTCCACCAAAAATTCTTTGAGACTCAGGCCTTCAATGAGGAATTGATAACCTTTCATGTATGAATCCTAATTGTTC
CTTGAATTTCCAAACATGAGTATTCTGATAACATCTTACACTATTTTATTTTTATTTTATATATTAATGTTTACTGCATTTACCATACTT
TCTTCAGGAACCACAAGTGTAATCTTTTGTAAACAGTATTTATTAGATTACATATAATAAGCAACAATAGTATATGATCCTTCTTTTATA
GTTAGACCTTGAAACAAGTCTAAACTATTTTTAAATTATTTGCAAAAAATGTGACTAATAAAAATCCCTAGTCTATTTTCAGGTAGATTC
TTGTACTTTGAGATTATCATAATCTTCTAACTGATATTTTATATTTTTCTAAAAACTTTTATAAGTTCTTTAGTTTTATTTCAGGCTTGA
ACATTGGTTCTGATTTGTATATCAACATATCAGAAGAATTAGTCAACTAAAGTTTGAAAACCTATGTAGCAGAGATCTGGTTCAGAAACT
GCTTCTATACTATACATTTAAAAATTAATCAGCAATTGATGGTATTATTTTTATATTAAGAAATGATAGGAACATTGACACTAATGTGGA
GGAATTTGCCAAATATTTTATTTCAAAATTTAGCCTCTGATATCATAACCACAAGATATTTTAAATCAACAGTTTCTAAGCATACTACCA
CAGTTTTTATGACCTCTCCATCATCTTGTGGTTTCTAGAGATTGACAGATACTATGTTTGTTTTATAGATATGGTAATTAATGAAACAAC
TTTAAATTGTCTTCCATTCTTTCTTCCTCAGTTCATTTCTTTTTGTCTTCCCACTGATAGTCTTTGGCAGCTCTTGAATAAATTCTACCT
GTTGGCATCAAGGGGAAGAAAATTAGCCTGGAAATTTTTATCTTTACATAAAGCCAATTATATAGCAGTTTGATTATGAATTCTAGGTGG
AAGAATTAGAATAGTCTTTGGAATGGGTTTTGGGTAACAGCCAAAATAGGGAAAAGGGTATTGTTAGGAAAGTTGTCTTGATATTAAGTA
TTTACTGTGAGTCCAGTAAGCCAAAGGACCAAACAAAATAGGTTCAGGGTTTCATTTTAATCTCAAAGATTCTGATTCTTACCCATATGT
CATCAGTTCAGTTTGGGACATGTGGTGCAGCATGTGTGAAGAAAATATTCATTAAAATGTAAAAATAAACACTTGAAATTGTCCACAACA
CTGAGCAAATATTCGTTATAATTAGGATGCCTACCTTTCTGGGATATTTGTAAGGTGCTGTAGTTTTTTTAACATGCTCCTGAATCTCCT
TTATTAGTTGTTCTTGATCATGTGACTTGTAATCAGGATTTAGAACGACAAAAGCCTTTACTACCTAAAATAAATATTTGAAACACCAGG

>97326_97326_2_USP31-ERI2_USP31_chr16_23113640_ENST00000219689_ERI2_chr16_20811724_ENST00000357967_length(amino acids)=949AA_BP=0
MSKVTAPGSGPPAAASGKEKRSFSKRLFRSGRAGGGGAGGPGASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGL
RSCFPPGPAAAPTPPPCPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGA
QGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMMPEGPS
FPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIP
TDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETPEIFRPEGILSQRDWDLGVCLEYECKRKQLLKPVFLNSWIDLRATYKLFYRR
KPKGLSGALQEVGIEFSGREHSGLDDSRNTALLAWKMIRDGCVMKITRSLNKVPTKKNFSILARNLNTIQVEEMSACNISIQGPSIYNKE
PKNIINPHEKVQMKSICANSPIKAQQDQLQVKNNIKASLHNVKSSLPLFNTKSSTSVGQLQSPTLNSPIYMQKQGKNEHLAFNTKSKAST
VGSELVLVSTTVPTVHHVSDLEMSSTLDCLPVLADWEDVVLLPASQPEENVDCTVPISDSDLEISFNSGERLMVLKELEMSSHENFGDIE
ETPQKSETSKSIVYKSPHTTIYNVKEAKDPGSDISAFKLPEHKSSTFNRVNANMSHPLVLGKHPLLSGGTKRNPCSPQAFPPAKKQPFTI
HEEKPTSSDCSPVRSSSWRRLPSILTSTVNLQEPWKSGKMTPPLCKCGRRSKRLVVSNNGPNHGKVFYCCPIGKYQENRKCCGYFKWEQT

--------------------------------------------------------------
>97326_97326_3_USP31-ERI2_USP31_chr16_23113640_ENST00000219689_ERI2_chr16_20811724_ENST00000564349_length(transcript)=4234nt_BP=1234nt
ATGTCCAAGGTAACGGCGCCTGGGTCCGGGCCGCCGGCGGCGGCGAGCGGGAAGGAGAAGCGCTCCTTCAGCAAGCGGCTGTTTCGGAGC
GGCCGCGCTGGCGGCGGCGGCGCGGGGGGCCCCGGGGCGTCCGGGCCGGCCGCGCCTTCCTCGCCCTCCTCGCCCTCCTCTGCACGCTCG
GTGGGCAGCTTCATGAGCCGCGTTCTCAAGACGCTGTCCACGCTCTCGCACCTTAGCTCTGAGGGCGCCGCCCCAGACCGCGGCGGCCTC
CGCAGCTGCTTCCCGCCCGGGCCGGCCGCCGCGCCCACGCCGCCGCCGTGCCCGCCGCCGCCCGCCTCTCCCGCGCCGCCCGCTTGCGCC
GCCGAGCCGGTGCCCGGCGTGGCGGGGCTCCGCAACCACGGCAACACGTGCTTCATGAACGCCACGCTGCAGTGCCTCAGCAACACCGAG
CTCTTCGCCGAGTACCTGGCGCTGGGCCAGTACCGGGCGGGGCGGCCCGAGCCCTCGCCTGACCCGGAGCAGCCTGCGGGCCGCGGCGCG
CAGGGCCAGGGCGAGGTCACTGAGCAGCTGGCGCACCTGGTGCGGGCCCTCTGGACCCTGGAGTACACCCCGCAGCACAGCCGCGACTTC
AAGACTATTGTGTCAAAGAATGCACTGCAGTACCGGGGAAATTCCCAACATGATGCCCAGGAGTTTCTGCTGTGGCTTTTGGACCGAGTT
CATGAAGACCTCAACCATTCAGTGAAGCAGAGTGGCCAGCCTCCTCTGAAGCCACCATCAGAGACTGATATGATGCCTGAGGGACCATCT
TTCCCTGTCTGTAGCACTTTTGTACAAGAACTCTTTCAAGCGCAATACAGATCTTCTTTGACGTGTCCTCATTGTCAGAAACAGAGCAAC
ACTTTTGATCCTTTCCTTTGCATTTCTTTGCCAATTCCTCTGCCCCACACAAGGCCTCTCTATGTCACTGTAGTGTATCAAGGCAAATGT
TCTCACTGCATGAGGATTGGTGTGGCCGTACCTCTGTCTGGGACTGTCGCCAGACTTCGGGAAGCAGTGTCTATGGAAACAAAGATCCCC
ACTGATCAGATTGTGTTAACAGAAATGTACTATGATGGGTTCCATCGTTCCTTTTGTGATACAGACGACCTGGAAACAGTCCATGAAAGC
GACTGCATTTTTGCCTTTGAGACTCCCGAAATATTTAGGCCTGAAGGAATTCTCAGTCAAAGAGACTGGGACTTGGGGGTTTGCCTGGAG
TATGAGTGTAAAAGAAAGCAGCTGTTAAAACCTGTGTTTTTAAATTCTTGGATTGATCTCAGAGCAACTTACAAGCTTTTCTATAGGAGA
AAACCAAAAGGACTAAGTGGTGCCTTGCAGGAAGTAGGAATAGAATTCTCAGGACGAGAACATTCTGGGTTGGACGATTCTCGGAATACT
GCCCTTCTTGCTTGGAAAATGATCAGAGATGGTTGTGTAATGAAAATTACAAGGTCGTTGAACAAGGTTCCCACTAAGAAGAATTTCAGC
ATTCTGGCCAGAAATTTGAATACAATTCAAGTTGAAGAAATGTCTGCCTGTAACATTAGCATCCAGGGTCCCAGCATATATAATAAGGAG
CCTAAAAATATAATAAATCCTCATGAAAAAGTTCAAATGAAGTCAATTTGTGCAAATTCTCCTATAAAGGCACAACAGGATCAATTACAA
GTAAAAAACAATATAAAAGCAAGTCTTCACAATGTCAAAAGTTCCTTACCTCTTTTTAATACTAAGTCCTCTACTTCTGTGGGGCAGTTG
CAGTCTCCTACCTTGAATTCACCTATCTATATGCAAAAGCAAGGAAAAAATGAACATCTTGCATTTAATACCAAATCTAAGGCTTCAACA
GTTGGTTCAGAATTGGTACTTGTTTCTACCACCGTTCCAACTGTTCATCATGTTTCTGATTTGGAAATGAGCTCTACTCTGGACTGTTTA
CCTGTGTTGGCTGATTGGGAGGATGTGGTTTTACTGCCAGCATCTCAGCCTGAGGAAAACGTAGACTGTACAGTTCCCATTAGTGACTCA
GACTTAGAGATTTCATTTAATTCTGGAGAAAGATTAATGGTTTTGAAAGAATTGGAAATGTCAAGTCATGAAAACTTTGGAGACATAGAG
GAAACTCCTCAAAAATCTGAGACTTCTAAGTCTATTGTGTACAAGAGTCCTCACACTACTATTTATAATGTAAAAGAAGCCAAAGATCCA
GGTTCAGATATTTCTGCCTTTAAGTTACCTGAACACAAATCAAGTACCTTCAACAGAGTTAATGCCAATATGTCTCATCCTTTAGTTTTG
GGGAAACATCCTCTTCTTTCAGGTGGTACCAAAAGGAATCCATGCAGTCCCCAAGCTTTCCCACCAGCAAAAAAACAACCCTTCACTATT
CATGAAGAAAAGCCTACATCATCTGATTGCTCCCCAGTAAGAAGTTCTTCCTGGAGGCGTCTCCCATCTATATTAACTTCTACAGTTAAC
CTACAAGAGCCATGGAAGAGTGGGAAAATGACACCTCCATTATGCAAGTGTGGTCGGAGATCTAAGAGACTTGTTGTTTCTAATAATGGA
CCGAACCATGGAAAAGTCTTCTATTGTTGCCCTATCGGGAAATACCAAGAAAACAGAAAATGTTGTGGTTATTTCAAATGGGAACAAACA
CTTCAAAAGGAAAGAGCCAACAGCATGGTTCCATCTCATTCCACAGGGGGACTCACTTTTAGTTCTCCAGAAACAAGCCATATTTGTGAC
AGAAATTTAAGTATTTCCACCAAAAATTCTTTGAGACTCAGGCCTTCAATGAGGAATTGATAACCTTTCATGTATGAATCCTAATTGTTC
CTTGAATTTCCAAACATGAGTATTCTGATAACATCTTACACTATTTTATTTTTATTTTATATATTAATGTTTACTGCATTTACCATACTT
TCTTCAGGAACCACAAGTGTAATCTTTTGTAAACAGTATTTATTAGATTACATATAATAAGCAACAATAGTATATGATCCTTCTTTTATA
GTTAGACCTTGAAACAAGTCTAAACTATTTTTAAATTATTTGCAAAAAATGTGACTAATAAAAATCCCTAGTCTATTTTCAGGTAGATTC
TTGTACTTTGAGATTATCATAATCTTCTAACTGATATTTTATATTTTTCTAAAAACTTTTATAAGTTCTTTAGTTTTATTTCAGGCTTGA
ACATTGGTTCTGATTTGTATATCAACATATCAGAAGAATTAGTCAACTAAAGTTTGAAAACCTATGTAGCAGAGATCTGGTTCAGAAACT
GCTTCTATACTATACATTTAAAAATTAATCAGCAATTGATGGTATTATTTTTATATTAAGAAATGATAGGAACATTGACACTAATGTGGA
GGAATTTGCCAAATATTTTATTTCAAAATTTAGCCTCTGATATCATAACCACAAGATATTTTAAATCAACAGTTTCTAAGCATACTACCA
CAGTTTTTATGACCTCTCCATCATCTTGTGGTTTCTAGAGATTGACAGATACTATGTTTGTTTTATAGATATGGTAATTAATGAAACAAC
TTTAAATTGTCTTCCATTCTTTCTTCCTCAGTTCATTTCTTTTTGTCTTCCCACTGATAGTCTTTGGCAGCTCTTGAATAAATTCTACCT
GTTGGCATCAAGGGGAAGAAAATTAGCCTGGAAATTTTTATCTTTACATAAAGCCAATTATATAGCAGTTTGATTATGAATTCTAGGTGG
AAGAATTAGAATAGTCTTTGGAATGGGTTTTGGGTAACAGCCAAAATAGGGAAAAGGGTATTGTTAGGAAAGTTGTCTTGATATTAAGTA
TTTACTGTGAGTCCAGTAAGCCAAAGGACCAAACAAAATAGGTTCAGGGTTTCATTTTAATCTCAAAGATTCTGATTCTTACCCATATGT
CATCAGTTCAGTTTGGGACATGTGGTGCAGCATGTGTGAAGAAAATATTCATTAAAATGTAAAAATAAACACTTGAAATTGTCCACAACA
CTGAGCAAATATTCGTTATAATTAGGATGCCTACCTTTCTGGGATATTTGTAAGGTGCTGTAGTTTTTTTAACATGCTCCTGAATCTCCT
TTATTAGTTGTTCTTGATCATGTGACTTGTAATCAGGATTTAGAACGACAAAAGCCTTTACTACCTAAAATAAATATTTGAAACACCAGG

>97326_97326_3_USP31-ERI2_USP31_chr16_23113640_ENST00000219689_ERI2_chr16_20811724_ENST00000564349_length(amino acids)=949AA_BP=0
MSKVTAPGSGPPAAASGKEKRSFSKRLFRSGRAGGGGAGGPGASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGL
RSCFPPGPAAAPTPPPCPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGA
QGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMMPEGPS
FPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIP
TDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETPEIFRPEGILSQRDWDLGVCLEYECKRKQLLKPVFLNSWIDLRATYKLFYRR
KPKGLSGALQEVGIEFSGREHSGLDDSRNTALLAWKMIRDGCVMKITRSLNKVPTKKNFSILARNLNTIQVEEMSACNISIQGPSIYNKE
PKNIINPHEKVQMKSICANSPIKAQQDQLQVKNNIKASLHNVKSSLPLFNTKSSTSVGQLQSPTLNSPIYMQKQGKNEHLAFNTKSKAST
VGSELVLVSTTVPTVHHVSDLEMSSTLDCLPVLADWEDVVLLPASQPEENVDCTVPISDSDLEISFNSGERLMVLKELEMSSHENFGDIE
ETPQKSETSKSIVYKSPHTTIYNVKEAKDPGSDISAFKLPEHKSSTFNRVNANMSHPLVLGKHPLLSGGTKRNPCSPQAFPPAKKQPFTI
HEEKPTSSDCSPVRSSSWRRLPSILTSTVNLQEPWKSGKMTPPLCKCGRRSKRLVVSNNGPNHGKVFYCCPIGKYQENRKCCGYFKWEQT

--------------------------------------------------------------
>97326_97326_4_USP31-ERI2_USP31_chr16_23113640_ENST00000219689_ERI2_chr16_20811724_ENST00000569729_length(transcript)=3374nt_BP=1234nt
ATGTCCAAGGTAACGGCGCCTGGGTCCGGGCCGCCGGCGGCGGCGAGCGGGAAGGAGAAGCGCTCCTTCAGCAAGCGGCTGTTTCGGAGC
GGCCGCGCTGGCGGCGGCGGCGCGGGGGGCCCCGGGGCGTCCGGGCCGGCCGCGCCTTCCTCGCCCTCCTCGCCCTCCTCTGCACGCTCG
GTGGGCAGCTTCATGAGCCGCGTTCTCAAGACGCTGTCCACGCTCTCGCACCTTAGCTCTGAGGGCGCCGCCCCAGACCGCGGCGGCCTC
CGCAGCTGCTTCCCGCCCGGGCCGGCCGCCGCGCCCACGCCGCCGCCGTGCCCGCCGCCGCCCGCCTCTCCCGCGCCGCCCGCTTGCGCC
GCCGAGCCGGTGCCCGGCGTGGCGGGGCTCCGCAACCACGGCAACACGTGCTTCATGAACGCCACGCTGCAGTGCCTCAGCAACACCGAG
CTCTTCGCCGAGTACCTGGCGCTGGGCCAGTACCGGGCGGGGCGGCCCGAGCCCTCGCCTGACCCGGAGCAGCCTGCGGGCCGCGGCGCG
CAGGGCCAGGGCGAGGTCACTGAGCAGCTGGCGCACCTGGTGCGGGCCCTCTGGACCCTGGAGTACACCCCGCAGCACAGCCGCGACTTC
AAGACTATTGTGTCAAAGAATGCACTGCAGTACCGGGGAAATTCCCAACATGATGCCCAGGAGTTTCTGCTGTGGCTTTTGGACCGAGTT
CATGAAGACCTCAACCATTCAGTGAAGCAGAGTGGCCAGCCTCCTCTGAAGCCACCATCAGAGACTGATATGATGCCTGAGGGACCATCT
TTCCCTGTCTGTAGCACTTTTGTACAAGAACTCTTTCAAGCGCAATACAGATCTTCTTTGACGTGTCCTCATTGTCAGAAACAGAGCAAC
ACTTTTGATCCTTTCCTTTGCATTTCTTTGCCAATTCCTCTGCCCCACACAAGGCCTCTCTATGTCACTGTAGTGTATCAAGGCAAATGT
TCTCACTGCATGAGGATTGGTGTGGCCGTACCTCTGTCTGGGACTGTCGCCAGACTTCGGGAAGCAGTGTCTATGGAAACAAAGATCCCC
ACTGATCAGATTGTGTTAACAGAAATGTACTATGATGGGTTCCATCGTTCCTTTTGTGATACAGACGACCTGGAAACAGTCCATGAAAGC
GACTGCATTTTTGCCTTTGAGACTCCCGAAATATTTAGGCCTGAAGGAATTCTCAGTCAAAGAGACTGGGACTTGGGGGTTTGCCTGGAG
TATGAGTGTAAAAGAAAGCAGCTGTTAAAACCTGTGTTTTTAAATTCTTGGATTGATCTCAGAGCAACTTACAAGCTTTTCTATAGGAGA
AAACCAAAAGGACTAAGTGGTGCCTTGCAGGAAGTAGGAATAGAATTCTCAGGACGAGAACATTCTGGGTTGGACGATTCTCGGAATACT
GCCCTTCTTGCTTGGAAAATGATCAGAGATGGTTGTGTAATGAAAATTACAAGGTCGTTGAACAAGGTGGTACCAAAAGGAATCCATGCA
GTCCCCAAGCTTTCCCACCAGCAAAAAAACAACCCTTCACTATTCATGAAGAAAAGCCTACATCATCTGATTGCTCCCCAGTAAGAAGTT
CTTCCTGGAGGCGTCTCCCATCTATATTAACTTCTACAGTTAACCTACAAGAGCCATGGAAGAGTGGGAAAATGACACCTCCATTATGCA
AGTGTGGTCGGAGATCTAAGAGACTTGTTGTTTCTAATAATGGACCGAACCATGGAAAAGTCTTCTATTGTTGCCCTATCGGGAAATACC
AAGAAAACAGAAAATGTTGTGGTTATTTCAAATGGGAACAAACACTTCAAAAGGAAAGAGCCAACAGCATGGTTCCATCTCATTCCACAG
GGGGACTCACTTTTAGTTCTCCAGAAACAAGCCATATTTGTGACAGAAATTTAAGTATTTCCACCAAAAATTCTTTGAGACTCAGGCCTT
CAATGAGGAATTGATAACCTTTCATGTATGAATCCTAATTGTTCCTTGAATTTCCAAACATGAGTATTCTGATAACATCTTACACTATTT
TATTTTTATTTTATATATTAATGTTTACTGCATTTACCATACTTTCTTCAGGAACCACAAGTGTAATCTTTTGTAAACAGTATTTATTAG
ATTACATATAATAAGCAACAATAGTATATGATCCTTCTTTTATAGTTAGACCTTGAAACAAGTCTAAACTATTTTTAAATTATTTGCAAA
AAATGTGACTAATAAAAATCCCTAGTCTATTTTCAGGTAGATTCTTGTACTTTGAGATTATCATAATCTTCTAACTGATATTTTATATTT
TTCTAAAAACTTTTATAAGTTCTTTAGTTTTATTTCAGGCTTGAACATTGGTTCTGATTTGTATATCAACATATCAGAAGAATTAGTCAA
CTAAAGTTTGAAAACCTATGTAGCAGAGATCTGGTTCAGAAACTGCTTCTATACTATACATTTAAAAATTAATCAGCAATTGATGGTATT
ATTTTTATATTAAGAAATGATAGGAACATTGACACTAATGTGGAGGAATTTGCCAAATATTTTATTTCAAAATTTAGCCTCTGATATCAT
AACCACAAGATATTTTAAATCAACAGTTTCTAAGCATACTACCACAGTTTTTATGACCTCTCCATCATCTTGTGGTTTCTAGAGATTGAC
AGATACTATGTTTGTTTTATAGATATGGTAATTAATGAAACAACTTTAAATTGTCTTCCATTCTTTCTTCCTCAGTTCATTTCTTTTTGT
CTTCCCACTGATAGTCTTTGGCAGCTCTTGAATAAATTCTACCTGTTGGCATCAAGGGGAAGAAAATTAGCCTGGAAATTTTTATCTTTA
CATAAAGCCAATTATATAGCAGTTTGATTATGAATTCTAGGTGGAAGAATTAGAATAGTCTTTGGAATGGGTTTTGGGTAACAGCCAAAA
TAGGGAAAAGGGTATTGTTAGGAAAGTTGTCTTGATATTAAGTATTTACTGTGAGTCCAGTAAGCCAAAGGACCAAACAAAATAGGTTCA
GGGTTTCATTTTAATCTCAAAGATTCTGATTCTTACCCATATGTCATCAGTTCAGTTTGGGACATGTGGTGCAGCATGTGTGAAGAAAAT
ATTCATTAAAATGTAAAAATAAACACTTGAAATTGTCCACAACACTGAGCAAATATTCGTTATAATTAGGATGCCTACCTTTCTGGGATA
TTTGTAAGGTGCTGTAGTTTTTTTAACATGCTCCTGAATCTCCTTTATTAGTTGTTCTTGATCATGTGACTTGTAATCAGGATTTAGAAC

>97326_97326_4_USP31-ERI2_USP31_chr16_23113640_ENST00000219689_ERI2_chr16_20811724_ENST00000569729_length(amino acids)=537AA_BP=411
MSKVTAPGSGPPAAASGKEKRSFSKRLFRSGRAGGGGAGGPGASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGL
RSCFPPGPAAAPTPPPCPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGA
QGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMMPEGPS
FPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIP
TDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETPEIFRPEGILSQRDWDLGVCLEYECKRKQLLKPVFLNSWIDLRATYKLFYRR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for USP31-ERI2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for USP31-ERI2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for USP31-ERI2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source