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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP34-SRRM1 (FusionGDB2 ID:97413)

Fusion Gene Summary for USP34-SRRM1

check button Fusion gene summary
Fusion gene informationFusion gene name: USP34-SRRM1
Fusion gene ID: 97413
HgeneTgene
Gene symbol

USP34

SRRM1

Gene ID

9736

10250

Gene nameubiquitin specific peptidase 34serine and arginine repetitive matrix 1
Synonyms-160-KD|POP101|SRM160
Cytomap

2p15

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34serine/arginine repetitive matrix protein 1SR-related nuclear matrix protein of 160 kDaSer/Arg-related nuclear matrix protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000398571, ENST00000472689, 
ENST00000479034, ENST00000537199, 
ENST00000323848, ENST00000374389, 
ENST00000447431, 
Fusion gene scores* DoF score30 X 29 X 14=121807 X 11 X 4=308
# samples 3711
** MAII scorelog2(37/12180*10)=-5.04084505227738
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/308*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP34 [Title/Abstract] AND SRRM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP34(61505300)-SRRM1(24997877), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP34

GO:0016579

protein deubiquitination

14715245

HgeneUSP34

GO:0071108

protein K48-linked deubiquitination

21383061

HgeneUSP34

GO:0090263

positive regulation of canonical Wnt signaling pathway

21383061


check buttonFusion gene breakpoints across USP34 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SRRM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GJ-01AUSP34chr2

61505300

-SRRM1chr1

24997877

+


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Fusion Gene ORF analysis for USP34-SRRM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000398571ENST00000479034USP34chr2

61505300

-SRRM1chr1

24997877

+
5CDS-intronENST00000398571ENST00000537199USP34chr2

61505300

-SRRM1chr1

24997877

+
In-frameENST00000398571ENST00000323848USP34chr2

61505300

-SRRM1chr1

24997877

+
In-frameENST00000398571ENST00000374389USP34chr2

61505300

-SRRM1chr1

24997877

+
In-frameENST00000398571ENST00000447431USP34chr2

61505300

-SRRM1chr1

24997877

+
intron-3CDSENST00000472689ENST00000323848USP34chr2

61505300

-SRRM1chr1

24997877

+
intron-3CDSENST00000472689ENST00000374389USP34chr2

61505300

-SRRM1chr1

24997877

+
intron-3CDSENST00000472689ENST00000447431USP34chr2

61505300

-SRRM1chr1

24997877

+
intron-3UTRENST00000472689ENST00000479034USP34chr2

61505300

-SRRM1chr1

24997877

+
intron-intronENST00000472689ENST00000537199USP34chr2

61505300

-SRRM1chr1

24997877

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398571USP34chr261505300-ENST00000323848SRRM1chr124997877+680655107758241915
ENST00000398571USP34chr261505300-ENST00000447431SRRM1chr124997877+620655107758241915
ENST00000398571USP34chr261505300-ENST00000374389SRRM1chr124997877+616555107758241915

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398571ENST00000323848USP34chr261505300-SRRM1chr124997877+0.0003921360.99960786
ENST00000398571ENST00000447431USP34chr261505300-SRRM1chr124997877+0.000572670.9994273
ENST00000398571ENST00000374389USP34chr261505300-SRRM1chr124997877+0.0006149810.999385

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Fusion Genomic Features for USP34-SRRM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
USP34chr261505299-SRRM1chr124997876+1.91E-060.9999981
USP34chr261505299-SRRM1chr124997876+1.91E-060.9999981

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for USP34-SRRM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:61505300/chr1:24997877)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSRRM1chr2:61505300chr1:24997877ENST000003238481417809_835800905.0Compositional biasNote=Lys-rich
TgeneSRRM1chr2:61505300chr1:24997877ENST000003238481417836_865800905.0Compositional biasNote=Ala-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP34chr2:61505300chr1:24997877ENST00000398571-41801894_223918113547.0DomainNote=USP
TgeneSRRM1chr2:61505300chr1:24997877ENST000003238481417163_726800905.0Compositional biasNote=Arg-rich
TgeneSRRM1chr2:61505300chr1:24997877ENST000003238481417210_417800905.0Compositional biasNote=Pro-rich
TgeneSRRM1chr2:61505300chr1:24997877ENST000003238481417278_756800905.0Compositional biasNote=Ser-rich
TgeneSRRM1chr2:61505300chr1:24997877ENST000003238481417550_799800905.0Compositional biasNote=Pro-rich
TgeneSRRM1chr2:61505300chr1:24997877ENST00000323848141727_126800905.0DomainPWI
TgeneSRRM1chr2:61505300chr1:24997877ENST0000032384814171_151800905.0RegionNote=Necessary for DNA and RNA-binding
TgeneSRRM1chr2:61505300chr1:24997877ENST0000032384814171_156800905.0RegionNote=Necessary for mRNA 3'-end cleavage and cytoplasmic accumulation
TgeneSRRM1chr2:61505300chr1:24997877ENST000003238481417300_688800905.0RegionNote=Necessary for speckles and matrix localization


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Fusion Gene Sequence for USP34-SRRM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97413_97413_1_USP34-SRRM1_USP34_chr2_61505300_ENST00000398571_SRRM1_chr1_24997877_ENST00000323848_length(transcript)=6806nt_BP=5510nt
TCTCTCCCCTCCCCCCCGCCGGTCGGGATCAGTCAGTGTGATCCGAAGCGGGGGAGGGGGGGGGCGGCGGCCGAACGATGTGCGAGAACT
GCGCAGACCTGGTGGAGGTGTTAAATGAAATATCAGATGTAGAAGGTGGTGATGGACTGCAGCTCAGAAAGGAACATACTCTCAAAATAT
TTACTTATATCAATTCCTGGACACAGAGGCAATGTCTATGCTGCTTCAAGGAATATAAGCATTTGGAGATTTTTAATCAAGTAGTGTGTG
CACTTATTAACTTAGTGATTGCCCAAGTTCAAGTGCTCCGGGACCAGCTTTGTAAACATTGTACTACCATTAACATAGATTCCACGTGGC
AAGATGAGAGTAATCAAGCAGAAGAACCACTGAATATAGATAGAGAGTGTAATGAAGGAAGTACAGAAAGACAAAAATCAATAGAAAAAA
AATCAAACTCTACAAGAATTTGTAATCTGACTGAGGAGGAATCTTCAAAGAGTTCTGATCCTTTTAGTTTATGGAGTACAGATGAGAAGG
AAAAACTCTTACTATGTGTGGCAAAAATTTTTCAAATTCAGTTTCCCTTATATACTGCTTACAAGCATAATACTCACCCTACTATTGAGG
ATATATCAACTCAAGAAAGTAACATATTAGGGGCATTCTGTGATATGAATGATGTAGAAGTACCATTGCATTTGCTTCGTTATGTATGTT
TGTTTTGTGGGAAAAATGGCCTTTCTCTCATGAAGGATTGCTTTGAATATGGAACTCCTGAAACTTTGCCATTTCTTATAGCACATGCGT
TTATTACAGTTGTGTCTAATATTAGAATATGGCTACATATTCCCGCTGTCATGCAGCACATTATACCTTTTAGGACCTATGTTATTAGGT
ATTTATGCAAGCTCTCGGATCAGGAGTTACGACAGAGTGCAGCTCGTAACATGGCTGACTTAATGTGGAGCACAGTCAAAGAACCATTGG
ATACAACATTATGCTTTGATAAAGAAAGCCTAGATCTTGCATTTAAGTACTTTATGTCACCTACTTTGACTATGAGGTTGGCTGGATTGA
GTCAGATAACAAATCAACTCCATACCTTCAATGATGTGTGCAATAATGAATCATTAGTATCGGACACAGAAACGTCCATTGCAAAAGAAC
TTGCAGACTGGCTTATTAGCAACAATGTGGTGGAGCATATATTTGGACCAAATTTACATATTGAGATTATCAAACAGTGCCAAGTGATTT
TGAATTTTTTGGCAGCAGAAGGGCGACTGAGTACTCAACATATTGACTGTATTTGGGCTGCAGCACAGTTGAAACATTGTAGTCGGTATA
TACATGACTTATTTCCTTCACTCATCAAGAATTTGGATCCCGTACCACTTAGACATCTACTTAATCTGGTCTCAGCTCTTGAGCCAAGTG
TTCATACTGAACAGACACTGTACTTGGCATCCATGTTAATTAAAGCACTGTGGAATAACGCACTAGCAGCTAAGGCTCAGTTATCTAAAC
AGAGTTCTTTTGCATCTTTATTAAATACTAATATTCCCATTGGAAATAAGAAAGAGGAAGAAGAGCTTAGAAGAACAGCTCCATCACCTT
GGTCACCTGCAGCTAGTCCTCAAAGCAGTGATAATAGCGATACACATCAAAGTGGAGGTAGTGACATTGAAATGGATGAGCAACTTATTA
ATAGAACCAAACATGTGCAACAACGACTTTCAGACACAGAGGAATCCATGCAGGGAAGTTCTGACGAAACTGCCAACAGTGGTGAAGATG
GAAGCAGTGGTCCTGGTAGCAGTAGTGGGCATAGTGATGGATCTAGCAATGAGGTTAATTCTAGCCACGCAAGCCAGTCAGCTGGGAGCC
CTGGCAGTGAGGTACAGTCAGAAGACATTGCAGATATTGAAGCCCTCAAAGAGGAAGATGAAGACGATGATCATGGTCATAATCCTCCCA
AAAGCAGTTGTGGTACAGATCTTCGGAATAGAAAGTTAGAGAGTCAAGCAGGCATTTGCCTGGGGGACTCCCAAGGCATGTCAGAAAGAA
ATGGGACAAGCAGCGGAACAGGAAAGGACCTGGTTTTTAACACTGAATCATTGCCATCAGTAGATAATCGAATGCGAATGCTGGATGCTT
GTTCACACTCTGAAGACCCAGAACATGATATTTCAGGGGAAATGAATGCTACTCATATAGCACAAGGGTCTCAGGAGTCTTGTATCACAC
GAACTGGGGACTTCCTTGGGGAGACTATTGGGAATGAATTATTTAATTGTCGACAATTTATTGGTCCACAGCATCACCACCACCACCACC
ACCATCACCACCACCACGATGGGCATATGGTTGATGATATGCTAAGTGCAGATGATGTCAGTTGTAGTAGCTCCCAGGTTAGTGCAAAAT
CAGAAAAAAATATGGCTGATTTTGATGGTGAAGAATCTGGATGTGAAGAGGAGCTAGTTCAGATTAATTCACATGCGGAACTGACATCTC
ACCTCCAACAACATCTTCCCAATTTAGCTTCCATTTACCATGAACATCTTAGTCAAGGACCTGTAGTTCATAAACATCAATTCAACAGTA
ATGCTGTTACAGACATTAATTTGGATAATGTTTGCAAGAAAGGAAATACTTTGTTGTGGGATATAGTCCAAGATGAAGATGCAGTTAATC
TTTCTGAAGGATTAATAAATGAAGCAGAGAAACTTCTTTGTTCGTTAGTATGTTGGTTTACAGATAGACAAATTCGAATGAGATTCATTG
AAGGTTGCCTTGAAAACTTGGGAAACAACAGATCAGTAGTAATTTCACTTCGTCTTCTTCCAAAACTATTTGGTACTTTTCAGCAGTTTG
GGAGCAGTTACGATACACACTGGATAACAATGTGGGCAGAAAAAGAACTGAACATGATGAAGCTTTTCTTTGATAATTTGGTATACTACA
TTCAAACTGTGAGAGAAGGAAGACAAAAACATGCACTGTACAGCCATAGTGCTGAAGTTCAAGTTCGTCTTCAATTCTTGACTTGTGTAT
TTTCAACTCTGGGATCACCTGATCATTTCAGGTTAAGTTTAGAGCAAGTTGACATCTTATGGCATTGTTTAGTAGAAGATTCTGAATGTT
ATGATGATGCACTCCATTGGTTTTTAAATCAAGTTCGAAGTAAAGATCAACATGCTATGGGTATGGAAACCTACAAACATCTTTTCCTGG
AGAAGATGCCCCAGCTAAAACCTGAAACAATTAGCATGACTGGCTTAAACCTGTTTCAGCATCTCTGTAACTTGGCTCGATTGGCTACCA
GTGCCTATGATGGTTGTTCAAATTCTGAGCTGTGTGGTATGGACCAATTTTGGGGCATTGCTTTAAGAGCACAATCTGGTGATGTCAGTC
GAGCAGCTATCCAGTATATTAACTCCTATTATATTAATGGTAAAACAGGTTTGGAGAAGGAGCAAGAATTTATTAGTAAGTGCATGGAGA
GTCTTATGATAGCTTCTAGCAGTCTTGAACAGGAATCACACTCAAGTCTCATGGTTATAGAAAGAGGACTCCTTATGCTGAAGACACATC
TGGAAGCGTTTAGGAGAAGGTTTGCATATCATCTGAGACAGTGGCAAATTGAAGGCACTGGTATTAGTAGTCATTTGAAAGCACTGAGTG
ACAAACAGTCTCTGCCGCTAAGGGTTGTATGCCAGCCAGCTGGACTTCCTGACAAGATGACTATTGAAATGTATCCTAGTGACCAGGTAG
CAGATCTTAGGGCTGAAGTAACTCATTGGTATGAAAATTTACAGAAAGAACAAATAAATCAACAAGCTCAGCTTCAGGAGTTTGGTCAAA
GCAACCGAAAAGGAGAGTTTCCTGGAGGCCTCATGGGACCTGTCAGGATGATTTCATCTGGACACGAGTTAACAACAGATTATGATGAAA
AAGCACTTCATGAGCTTGGTTTTAAGGATATGCAGATGGTATTTGTATCTTTGGGTGCACCAAGGAGAGAGCGGAAAGGGGAAGGTGTTC
AGCTGCCAGCATCTTGCCTCCCACCCCCTCAGAAGGACAACATTCCAATGCTTTTGCTTTTACAAGAGCCTCATTTAACTACTCTTTTTG
ATTTATTAGAGATGCTTGCATCATTTAAACCACCCTCAGGAAAAGTGGCAGTGGATGATAGTGAGAGCTTACGATGTGAAGAACTTCATC
TTCATGCAGAAAATCTGTCTAGGCGGGTCTGGGAGCTACTGATGCTTCTTCCTACATGTCCTAATATGTTGATGGCATTCCAGAATATCT
CAGATGAGCAGAGTAATGATGGATTTAATTGGAAAGAACTTCTCAAAATTAAGAGCGCCCACAAGCTATTGTATGCTCTGGAAATTATTG
AAGCACTGGGAAAACCTAATAGAAGAATAAGGAGGGAGTCTACGGGAAGTTACAGTGATCTTTATCCAGATTCAGATGATTCAAGTGAAG
ATCAAGTGGAAAATAGTAAAAATTCCTGGAGTTGCAAGTTTGTTGCTGCTGGAGGGCTTCAACAGTTATTAGAAATTTTTAATTCTGGAA
TTCTAGAGCCTAAAGAGCAGGAATCATGGACTGTGTGGCAGCTAGACTGTCTTGCTTGCTTGCTGAAGTTAATATGCCAGTTTGCAGTAG
ATCCATCCGATTTGGATTTAGCTTATCATGATGTCTTTGCCTGGTCTGGTATAGCGGAAAGCCATAGGAAAAGAACCTGGCCTGGCAAAT
CAAGGAAGGCTGCTGGTGATCATGCTAAGGGTCTTCATATACCACGATTAACAGAGGTATTTCTTGTTCTTGTCCAAGGAACCAGTTTGA
TTCAGCGACTTATGTCTGTTGCTTATACGTATGATAATCTGGCTCCTAGAGTTTTAAAAGCTCAGTCTGATCACAGGTCTAGACATGAAG
TTTCACATTATTCAATGTGGCTCTTGGTGAGTTGGGCTCATTGCTGTTCTTTAGTGAAATCTAGCCTTGCTGATAGCGATCATTTACAAG
ATTGGCTAAAGAAATTGACTCTCCTTATTCCTGAGACTGCAGTTCGTCATGAATCATGCAGTGGTCTCTATAAGTTATCCCTGTCAGGGC
TGGATGGAGGAGACTCAATCAATCGTTCTTTTCTGCTATTGGCTGCCTCAACATTATTGAAATTTCTTCCTGATGCTCAAGCACTCAAAC
CTATTAGGATAGATGATTATGAGGAAGAACCAATATTAAAACCAGGATGTAAAGAGTATTTTTGGTTGTTATGCAAATTAGTTGACAACA
TACATATAAAGGACGCTAGTCAGACAACGCTCCTCGACTTAGATGCCTTGGCAAGACATTTGGCTGACTGTATTCGAAGTAGGGAGATCC
TTGATCATCAGGATGGTAATGTAGAAGATGATGGGCTTACAGGACTCCTAAGGCTTGCAACAAGTGTTGTTAAACACAAACCACCCTTTA
AATTTTCAAGGGAAGGACAGAATTCAGATCAGGAAGGAGGTGGAAAGAAAAAGAAGAAAAAGAAGGACAAGAAACACAAAAAGGATAAGA
AGCACAAGAAGCACAAAAAACACAAGAAGGAAAAGGCTGTGGCTGCAGCTGCTGCAGCTGCTGTGACCCCTGCAGCCATTGCAGCTGCCA
CAACCACATTAGCACAGGAAGAGCCAGTGGCAGCGCCAGAGCCGAAGAAGGAGACTGAAAGTGAAGCTGAAGATAACCTTGATGATTTAG
AAAAGCACCTGCGTGAAAAGGCCCTGAGATCAATGAGGAAGGCCCAAGTGTCCCCACAGTCTTAGGGGGAAATGTTTGTTATGATGTAAA
TTTTATTTGGTTTGTACGCAGTTCAATTTCAAAATTGCTAAAATGTGTTTGAGCTTTAGACTATAACATTTGTTGTAATAATTGCTAGGT
TGAAGTTCAACATGTAAAAAAAGGGGGCATGGATTTACATTGCAAAAGGTGTCCACAGTGTATTAGTGACATTCTTTCATTGACAGCTGA
CATAATTCATTGAGTGAAATATTTTAAGCCAAAAAAAAATTCCCTTTTTAAAAAAGGGGGTTTAAATACTGTTGGCATTTTTATGGTTCC
TTTAAATGCCCTAGCTATTCCCAGAGGGGTTTTTTTGTTTGTTTTTTTGGTTTTGATTTTCTTTTTGTTTTTCTTTCTTCTTCTTATTTT
TTTCATTTGAGTCTTAGCTCCCATTTAAGTTATGCTTCTGACCTTGTATGGTCTGTAAGCTTGCCCAGAAATAAGACCACTGTTTTGAAC
TACCACAAAAGTATAAATGAATATTTTAATGCCACAATCTTTCCTGTTGCCTGTGGAGTCTCTGCTGAAATGAATCAGGATTCGAGCTCT
AGGATGAGACAGAAAATGAAAGCATGTTGTTTGCCAGGACACTGTGGGTTTATATTGATGTGTAACAAGTTGATTTGGAACACTGGACTC
TCATTCTGTTATTCTGGTTTTGTTTTTTTTGTTTTGTTTTTTTTCTTTTGTAAAGGCAATGAGCTAGTCCCAGAAAGGATCCTTCAGTTA
CATACAATTTGTTTAATGAAATGTCATGGCTCTGTTCATATTTTTGTCTTGTTCTTCCAATTGGTATATACAACTTTCAGAGCCTCTTGT
ATTTGGAAGGCTGGAAGGGCCCAGACTTTGGAATAGTGTCTTGGTTTCACTGTTTTTGTTTTGATTTTTTTTTTGTTTTGATTTTTTTTA

>97413_97413_1_USP34-SRRM1_USP34_chr2_61505300_ENST00000398571_SRRM1_chr1_24997877_ENST00000323848_length(amino acids)=1915AA_BP=1811
MCENCADLVEVLNEISDVEGGDGLQLRKEHTLKIFTYINSWTQRQCLCCFKEYKHLEIFNQVVCALINLVIAQVQVLRDQLCKHCTTINI
DSTWQDESNQAEEPLNIDRECNEGSTERQKSIEKKSNSTRICNLTEEESSKSSDPFSLWSTDEKEKLLLCVAKIFQIQFPLYTAYKHNTH
PTIEDISTQESNILGAFCDMNDVEVPLHLLRYVCLFCGKNGLSLMKDCFEYGTPETLPFLIAHAFITVVSNIRIWLHIPAVMQHIIPFRT
YVIRYLCKLSDQELRQSAARNMADLMWSTVKEPLDTTLCFDKESLDLAFKYFMSPTLTMRLAGLSQITNQLHTFNDVCNNESLVSDTETS
IAKELADWLISNNVVEHIFGPNLHIEIIKQCQVILNFLAAEGRLSTQHIDCIWAAAQLKHCSRYIHDLFPSLIKNLDPVPLRHLLNLVSA
LEPSVHTEQTLYLASMLIKALWNNALAAKAQLSKQSSFASLLNTNIPIGNKKEEEELRRTAPSPWSPAASPQSSDNSDTHQSGGSDIEMD
EQLINRTKHVQQRLSDTEESMQGSSDETANSGEDGSSGPGSSSGHSDGSSNEVNSSHASQSAGSPGSEVQSEDIADIEALKEEDEDDDHG
HNPPKSSCGTDLRNRKLESQAGICLGDSQGMSERNGTSSGTGKDLVFNTESLPSVDNRMRMLDACSHSEDPEHDISGEMNATHIAQGSQE
SCITRTGDFLGETIGNELFNCRQFIGPQHHHHHHHHHHHHDGHMVDDMLSADDVSCSSSQVSAKSEKNMADFDGEESGCEEELVQINSHA
ELTSHLQQHLPNLASIYHEHLSQGPVVHKHQFNSNAVTDINLDNVCKKGNTLLWDIVQDEDAVNLSEGLINEAEKLLCSLVCWFTDRQIR
MRFIEGCLENLGNNRSVVISLRLLPKLFGTFQQFGSSYDTHWITMWAEKELNMMKLFFDNLVYYIQTVREGRQKHALYSHSAEVQVRLQF
LTCVFSTLGSPDHFRLSLEQVDILWHCLVEDSECYDDALHWFLNQVRSKDQHAMGMETYKHLFLEKMPQLKPETISMTGLNLFQHLCNLA
RLATSAYDGCSNSELCGMDQFWGIALRAQSGDVSRAAIQYINSYYINGKTGLEKEQEFISKCMESLMIASSSLEQESHSSLMVIERGLLM
LKTHLEAFRRRFAYHLRQWQIEGTGISSHLKALSDKQSLPLRVVCQPAGLPDKMTIEMYPSDQVADLRAEVTHWYENLQKEQINQQAQLQ
EFGQSNRKGEFPGGLMGPVRMISSGHELTTDYDEKALHELGFKDMQMVFVSLGAPRRERKGEGVQLPASCLPPPQKDNIPMLLLLQEPHL
TTLFDLLEMLASFKPPSGKVAVDDSESLRCEELHLHAENLSRRVWELLMLLPTCPNMLMAFQNISDEQSNDGFNWKELLKIKSAHKLLYA
LEIIEALGKPNRRIRRESTGSYSDLYPDSDDSSEDQVENSKNSWSCKFVAAGGLQQLLEIFNSGILEPKEQESWTVWQLDCLACLLKLIC
QFAVDPSDLDLAYHDVFAWSGIAESHRKRTWPGKSRKAAGDHAKGLHIPRLTEVFLVLVQGTSLIQRLMSVAYTYDNLAPRVLKAQSDHR
SRHEVSHYSMWLLVSWAHCCSLVKSSLADSDHLQDWLKKLTLLIPETAVRHESCSGLYKLSLSGLDGGDSINRSFLLLAASTLLKFLPDA
QALKPIRIDDYEEEPILKPGCKEYFWLLCKLVDNIHIKDASQTTLLDLDALARHLADCIRSREILDHQDGNVEDDGLTGLLRLATSVVKH
KPPFKFSREGQNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEPKKETESEAEDN

--------------------------------------------------------------
>97413_97413_2_USP34-SRRM1_USP34_chr2_61505300_ENST00000398571_SRRM1_chr1_24997877_ENST00000374389_length(transcript)=6165nt_BP=5510nt
TCTCTCCCCTCCCCCCCGCCGGTCGGGATCAGTCAGTGTGATCCGAAGCGGGGGAGGGGGGGGGCGGCGGCCGAACGATGTGCGAGAACT
GCGCAGACCTGGTGGAGGTGTTAAATGAAATATCAGATGTAGAAGGTGGTGATGGACTGCAGCTCAGAAAGGAACATACTCTCAAAATAT
TTACTTATATCAATTCCTGGACACAGAGGCAATGTCTATGCTGCTTCAAGGAATATAAGCATTTGGAGATTTTTAATCAAGTAGTGTGTG
CACTTATTAACTTAGTGATTGCCCAAGTTCAAGTGCTCCGGGACCAGCTTTGTAAACATTGTACTACCATTAACATAGATTCCACGTGGC
AAGATGAGAGTAATCAAGCAGAAGAACCACTGAATATAGATAGAGAGTGTAATGAAGGAAGTACAGAAAGACAAAAATCAATAGAAAAAA
AATCAAACTCTACAAGAATTTGTAATCTGACTGAGGAGGAATCTTCAAAGAGTTCTGATCCTTTTAGTTTATGGAGTACAGATGAGAAGG
AAAAACTCTTACTATGTGTGGCAAAAATTTTTCAAATTCAGTTTCCCTTATATACTGCTTACAAGCATAATACTCACCCTACTATTGAGG
ATATATCAACTCAAGAAAGTAACATATTAGGGGCATTCTGTGATATGAATGATGTAGAAGTACCATTGCATTTGCTTCGTTATGTATGTT
TGTTTTGTGGGAAAAATGGCCTTTCTCTCATGAAGGATTGCTTTGAATATGGAACTCCTGAAACTTTGCCATTTCTTATAGCACATGCGT
TTATTACAGTTGTGTCTAATATTAGAATATGGCTACATATTCCCGCTGTCATGCAGCACATTATACCTTTTAGGACCTATGTTATTAGGT
ATTTATGCAAGCTCTCGGATCAGGAGTTACGACAGAGTGCAGCTCGTAACATGGCTGACTTAATGTGGAGCACAGTCAAAGAACCATTGG
ATACAACATTATGCTTTGATAAAGAAAGCCTAGATCTTGCATTTAAGTACTTTATGTCACCTACTTTGACTATGAGGTTGGCTGGATTGA
GTCAGATAACAAATCAACTCCATACCTTCAATGATGTGTGCAATAATGAATCATTAGTATCGGACACAGAAACGTCCATTGCAAAAGAAC
TTGCAGACTGGCTTATTAGCAACAATGTGGTGGAGCATATATTTGGACCAAATTTACATATTGAGATTATCAAACAGTGCCAAGTGATTT
TGAATTTTTTGGCAGCAGAAGGGCGACTGAGTACTCAACATATTGACTGTATTTGGGCTGCAGCACAGTTGAAACATTGTAGTCGGTATA
TACATGACTTATTTCCTTCACTCATCAAGAATTTGGATCCCGTACCACTTAGACATCTACTTAATCTGGTCTCAGCTCTTGAGCCAAGTG
TTCATACTGAACAGACACTGTACTTGGCATCCATGTTAATTAAAGCACTGTGGAATAACGCACTAGCAGCTAAGGCTCAGTTATCTAAAC
AGAGTTCTTTTGCATCTTTATTAAATACTAATATTCCCATTGGAAATAAGAAAGAGGAAGAAGAGCTTAGAAGAACAGCTCCATCACCTT
GGTCACCTGCAGCTAGTCCTCAAAGCAGTGATAATAGCGATACACATCAAAGTGGAGGTAGTGACATTGAAATGGATGAGCAACTTATTA
ATAGAACCAAACATGTGCAACAACGACTTTCAGACACAGAGGAATCCATGCAGGGAAGTTCTGACGAAACTGCCAACAGTGGTGAAGATG
GAAGCAGTGGTCCTGGTAGCAGTAGTGGGCATAGTGATGGATCTAGCAATGAGGTTAATTCTAGCCACGCAAGCCAGTCAGCTGGGAGCC
CTGGCAGTGAGGTACAGTCAGAAGACATTGCAGATATTGAAGCCCTCAAAGAGGAAGATGAAGACGATGATCATGGTCATAATCCTCCCA
AAAGCAGTTGTGGTACAGATCTTCGGAATAGAAAGTTAGAGAGTCAAGCAGGCATTTGCCTGGGGGACTCCCAAGGCATGTCAGAAAGAA
ATGGGACAAGCAGCGGAACAGGAAAGGACCTGGTTTTTAACACTGAATCATTGCCATCAGTAGATAATCGAATGCGAATGCTGGATGCTT
GTTCACACTCTGAAGACCCAGAACATGATATTTCAGGGGAAATGAATGCTACTCATATAGCACAAGGGTCTCAGGAGTCTTGTATCACAC
GAACTGGGGACTTCCTTGGGGAGACTATTGGGAATGAATTATTTAATTGTCGACAATTTATTGGTCCACAGCATCACCACCACCACCACC
ACCATCACCACCACCACGATGGGCATATGGTTGATGATATGCTAAGTGCAGATGATGTCAGTTGTAGTAGCTCCCAGGTTAGTGCAAAAT
CAGAAAAAAATATGGCTGATTTTGATGGTGAAGAATCTGGATGTGAAGAGGAGCTAGTTCAGATTAATTCACATGCGGAACTGACATCTC
ACCTCCAACAACATCTTCCCAATTTAGCTTCCATTTACCATGAACATCTTAGTCAAGGACCTGTAGTTCATAAACATCAATTCAACAGTA
ATGCTGTTACAGACATTAATTTGGATAATGTTTGCAAGAAAGGAAATACTTTGTTGTGGGATATAGTCCAAGATGAAGATGCAGTTAATC
TTTCTGAAGGATTAATAAATGAAGCAGAGAAACTTCTTTGTTCGTTAGTATGTTGGTTTACAGATAGACAAATTCGAATGAGATTCATTG
AAGGTTGCCTTGAAAACTTGGGAAACAACAGATCAGTAGTAATTTCACTTCGTCTTCTTCCAAAACTATTTGGTACTTTTCAGCAGTTTG
GGAGCAGTTACGATACACACTGGATAACAATGTGGGCAGAAAAAGAACTGAACATGATGAAGCTTTTCTTTGATAATTTGGTATACTACA
TTCAAACTGTGAGAGAAGGAAGACAAAAACATGCACTGTACAGCCATAGTGCTGAAGTTCAAGTTCGTCTTCAATTCTTGACTTGTGTAT
TTTCAACTCTGGGATCACCTGATCATTTCAGGTTAAGTTTAGAGCAAGTTGACATCTTATGGCATTGTTTAGTAGAAGATTCTGAATGTT
ATGATGATGCACTCCATTGGTTTTTAAATCAAGTTCGAAGTAAAGATCAACATGCTATGGGTATGGAAACCTACAAACATCTTTTCCTGG
AGAAGATGCCCCAGCTAAAACCTGAAACAATTAGCATGACTGGCTTAAACCTGTTTCAGCATCTCTGTAACTTGGCTCGATTGGCTACCA
GTGCCTATGATGGTTGTTCAAATTCTGAGCTGTGTGGTATGGACCAATTTTGGGGCATTGCTTTAAGAGCACAATCTGGTGATGTCAGTC
GAGCAGCTATCCAGTATATTAACTCCTATTATATTAATGGTAAAACAGGTTTGGAGAAGGAGCAAGAATTTATTAGTAAGTGCATGGAGA
GTCTTATGATAGCTTCTAGCAGTCTTGAACAGGAATCACACTCAAGTCTCATGGTTATAGAAAGAGGACTCCTTATGCTGAAGACACATC
TGGAAGCGTTTAGGAGAAGGTTTGCATATCATCTGAGACAGTGGCAAATTGAAGGCACTGGTATTAGTAGTCATTTGAAAGCACTGAGTG
ACAAACAGTCTCTGCCGCTAAGGGTTGTATGCCAGCCAGCTGGACTTCCTGACAAGATGACTATTGAAATGTATCCTAGTGACCAGGTAG
CAGATCTTAGGGCTGAAGTAACTCATTGGTATGAAAATTTACAGAAAGAACAAATAAATCAACAAGCTCAGCTTCAGGAGTTTGGTCAAA
GCAACCGAAAAGGAGAGTTTCCTGGAGGCCTCATGGGACCTGTCAGGATGATTTCATCTGGACACGAGTTAACAACAGATTATGATGAAA
AAGCACTTCATGAGCTTGGTTTTAAGGATATGCAGATGGTATTTGTATCTTTGGGTGCACCAAGGAGAGAGCGGAAAGGGGAAGGTGTTC
AGCTGCCAGCATCTTGCCTCCCACCCCCTCAGAAGGACAACATTCCAATGCTTTTGCTTTTACAAGAGCCTCATTTAACTACTCTTTTTG
ATTTATTAGAGATGCTTGCATCATTTAAACCACCCTCAGGAAAAGTGGCAGTGGATGATAGTGAGAGCTTACGATGTGAAGAACTTCATC
TTCATGCAGAAAATCTGTCTAGGCGGGTCTGGGAGCTACTGATGCTTCTTCCTACATGTCCTAATATGTTGATGGCATTCCAGAATATCT
CAGATGAGCAGAGTAATGATGGATTTAATTGGAAAGAACTTCTCAAAATTAAGAGCGCCCACAAGCTATTGTATGCTCTGGAAATTATTG
AAGCACTGGGAAAACCTAATAGAAGAATAAGGAGGGAGTCTACGGGAAGTTACAGTGATCTTTATCCAGATTCAGATGATTCAAGTGAAG
ATCAAGTGGAAAATAGTAAAAATTCCTGGAGTTGCAAGTTTGTTGCTGCTGGAGGGCTTCAACAGTTATTAGAAATTTTTAATTCTGGAA
TTCTAGAGCCTAAAGAGCAGGAATCATGGACTGTGTGGCAGCTAGACTGTCTTGCTTGCTTGCTGAAGTTAATATGCCAGTTTGCAGTAG
ATCCATCCGATTTGGATTTAGCTTATCATGATGTCTTTGCCTGGTCTGGTATAGCGGAAAGCCATAGGAAAAGAACCTGGCCTGGCAAAT
CAAGGAAGGCTGCTGGTGATCATGCTAAGGGTCTTCATATACCACGATTAACAGAGGTATTTCTTGTTCTTGTCCAAGGAACCAGTTTGA
TTCAGCGACTTATGTCTGTTGCTTATACGTATGATAATCTGGCTCCTAGAGTTTTAAAAGCTCAGTCTGATCACAGGTCTAGACATGAAG
TTTCACATTATTCAATGTGGCTCTTGGTGAGTTGGGCTCATTGCTGTTCTTTAGTGAAATCTAGCCTTGCTGATAGCGATCATTTACAAG
ATTGGCTAAAGAAATTGACTCTCCTTATTCCTGAGACTGCAGTTCGTCATGAATCATGCAGTGGTCTCTATAAGTTATCCCTGTCAGGGC
TGGATGGAGGAGACTCAATCAATCGTTCTTTTCTGCTATTGGCTGCCTCAACATTATTGAAATTTCTTCCTGATGCTCAAGCACTCAAAC
CTATTAGGATAGATGATTATGAGGAAGAACCAATATTAAAACCAGGATGTAAAGAGTATTTTTGGTTGTTATGCAAATTAGTTGACAACA
TACATATAAAGGACGCTAGTCAGACAACGCTCCTCGACTTAGATGCCTTGGCAAGACATTTGGCTGACTGTATTCGAAGTAGGGAGATCC
TTGATCATCAGGATGGTAATGTAGAAGATGATGGGCTTACAGGACTCCTAAGGCTTGCAACAAGTGTTGTTAAACACAAACCACCCTTTA
AATTTTCAAGGGAAGGACAGAATTCAGATCAGGAAGGAGGTGGAAAGAAAAAGAAGAAAAAGAAGGACAAGAAACACAAAAAGGATAAGA
AGCACAAGAAGCACAAAAAACACAAGAAGGAAAAGGCTGTGGCTGCAGCTGCTGCAGCTGCTGTGACCCCTGCAGCCATTGCAGCTGCCA
CAACCACATTAGCACAGGAAGAGCCAGTGGCAGCGCCAGAGCCGAAGAAGGAGACTGAAAGTGAAGCTGAAGATAACCTTGATGATTTAG
AAAAGCACCTGCGTGAAAAGGCCCTGAGATCAATGAGGAAGGCCCAAGTGTCCCCACAGTCTTAGGGGGAAATGTTTGTTATGATGTAAA
TTTTATTTGGTTTGTACGCAGTTCAATTTCAAAATTGCTAAAATGTGTTTGAGCTTTAGACTATAACATTTGTTGTAATAATTGCTAGGT
TGAAGTTCAACATGTAAAAAAAGGGGGCATGGATTTACATTGCAAAAGGTGTCCACAGTGTATTAGTGACATTCTTTCATTGACAGCTGA
CATAATTCATTGAGTGAAATATTTTAAGCCAAAAAAAAATTCCCTTTTTAAAAAAGGGGGTTTAAATACTGTTGGCATTTTTATGGTTCC

>97413_97413_2_USP34-SRRM1_USP34_chr2_61505300_ENST00000398571_SRRM1_chr1_24997877_ENST00000374389_length(amino acids)=1915AA_BP=1811
MCENCADLVEVLNEISDVEGGDGLQLRKEHTLKIFTYINSWTQRQCLCCFKEYKHLEIFNQVVCALINLVIAQVQVLRDQLCKHCTTINI
DSTWQDESNQAEEPLNIDRECNEGSTERQKSIEKKSNSTRICNLTEEESSKSSDPFSLWSTDEKEKLLLCVAKIFQIQFPLYTAYKHNTH
PTIEDISTQESNILGAFCDMNDVEVPLHLLRYVCLFCGKNGLSLMKDCFEYGTPETLPFLIAHAFITVVSNIRIWLHIPAVMQHIIPFRT
YVIRYLCKLSDQELRQSAARNMADLMWSTVKEPLDTTLCFDKESLDLAFKYFMSPTLTMRLAGLSQITNQLHTFNDVCNNESLVSDTETS
IAKELADWLISNNVVEHIFGPNLHIEIIKQCQVILNFLAAEGRLSTQHIDCIWAAAQLKHCSRYIHDLFPSLIKNLDPVPLRHLLNLVSA
LEPSVHTEQTLYLASMLIKALWNNALAAKAQLSKQSSFASLLNTNIPIGNKKEEEELRRTAPSPWSPAASPQSSDNSDTHQSGGSDIEMD
EQLINRTKHVQQRLSDTEESMQGSSDETANSGEDGSSGPGSSSGHSDGSSNEVNSSHASQSAGSPGSEVQSEDIADIEALKEEDEDDDHG
HNPPKSSCGTDLRNRKLESQAGICLGDSQGMSERNGTSSGTGKDLVFNTESLPSVDNRMRMLDACSHSEDPEHDISGEMNATHIAQGSQE
SCITRTGDFLGETIGNELFNCRQFIGPQHHHHHHHHHHHHDGHMVDDMLSADDVSCSSSQVSAKSEKNMADFDGEESGCEEELVQINSHA
ELTSHLQQHLPNLASIYHEHLSQGPVVHKHQFNSNAVTDINLDNVCKKGNTLLWDIVQDEDAVNLSEGLINEAEKLLCSLVCWFTDRQIR
MRFIEGCLENLGNNRSVVISLRLLPKLFGTFQQFGSSYDTHWITMWAEKELNMMKLFFDNLVYYIQTVREGRQKHALYSHSAEVQVRLQF
LTCVFSTLGSPDHFRLSLEQVDILWHCLVEDSECYDDALHWFLNQVRSKDQHAMGMETYKHLFLEKMPQLKPETISMTGLNLFQHLCNLA
RLATSAYDGCSNSELCGMDQFWGIALRAQSGDVSRAAIQYINSYYINGKTGLEKEQEFISKCMESLMIASSSLEQESHSSLMVIERGLLM
LKTHLEAFRRRFAYHLRQWQIEGTGISSHLKALSDKQSLPLRVVCQPAGLPDKMTIEMYPSDQVADLRAEVTHWYENLQKEQINQQAQLQ
EFGQSNRKGEFPGGLMGPVRMISSGHELTTDYDEKALHELGFKDMQMVFVSLGAPRRERKGEGVQLPASCLPPPQKDNIPMLLLLQEPHL
TTLFDLLEMLASFKPPSGKVAVDDSESLRCEELHLHAENLSRRVWELLMLLPTCPNMLMAFQNISDEQSNDGFNWKELLKIKSAHKLLYA
LEIIEALGKPNRRIRRESTGSYSDLYPDSDDSSEDQVENSKNSWSCKFVAAGGLQQLLEIFNSGILEPKEQESWTVWQLDCLACLLKLIC
QFAVDPSDLDLAYHDVFAWSGIAESHRKRTWPGKSRKAAGDHAKGLHIPRLTEVFLVLVQGTSLIQRLMSVAYTYDNLAPRVLKAQSDHR
SRHEVSHYSMWLLVSWAHCCSLVKSSLADSDHLQDWLKKLTLLIPETAVRHESCSGLYKLSLSGLDGGDSINRSFLLLAASTLLKFLPDA
QALKPIRIDDYEEEPILKPGCKEYFWLLCKLVDNIHIKDASQTTLLDLDALARHLADCIRSREILDHQDGNVEDDGLTGLLRLATSVVKH
KPPFKFSREGQNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEPKKETESEAEDN

--------------------------------------------------------------
>97413_97413_3_USP34-SRRM1_USP34_chr2_61505300_ENST00000398571_SRRM1_chr1_24997877_ENST00000447431_length(transcript)=6206nt_BP=5510nt
TCTCTCCCCTCCCCCCCGCCGGTCGGGATCAGTCAGTGTGATCCGAAGCGGGGGAGGGGGGGGGCGGCGGCCGAACGATGTGCGAGAACT
GCGCAGACCTGGTGGAGGTGTTAAATGAAATATCAGATGTAGAAGGTGGTGATGGACTGCAGCTCAGAAAGGAACATACTCTCAAAATAT
TTACTTATATCAATTCCTGGACACAGAGGCAATGTCTATGCTGCTTCAAGGAATATAAGCATTTGGAGATTTTTAATCAAGTAGTGTGTG
CACTTATTAACTTAGTGATTGCCCAAGTTCAAGTGCTCCGGGACCAGCTTTGTAAACATTGTACTACCATTAACATAGATTCCACGTGGC
AAGATGAGAGTAATCAAGCAGAAGAACCACTGAATATAGATAGAGAGTGTAATGAAGGAAGTACAGAAAGACAAAAATCAATAGAAAAAA
AATCAAACTCTACAAGAATTTGTAATCTGACTGAGGAGGAATCTTCAAAGAGTTCTGATCCTTTTAGTTTATGGAGTACAGATGAGAAGG
AAAAACTCTTACTATGTGTGGCAAAAATTTTTCAAATTCAGTTTCCCTTATATACTGCTTACAAGCATAATACTCACCCTACTATTGAGG
ATATATCAACTCAAGAAAGTAACATATTAGGGGCATTCTGTGATATGAATGATGTAGAAGTACCATTGCATTTGCTTCGTTATGTATGTT
TGTTTTGTGGGAAAAATGGCCTTTCTCTCATGAAGGATTGCTTTGAATATGGAACTCCTGAAACTTTGCCATTTCTTATAGCACATGCGT
TTATTACAGTTGTGTCTAATATTAGAATATGGCTACATATTCCCGCTGTCATGCAGCACATTATACCTTTTAGGACCTATGTTATTAGGT
ATTTATGCAAGCTCTCGGATCAGGAGTTACGACAGAGTGCAGCTCGTAACATGGCTGACTTAATGTGGAGCACAGTCAAAGAACCATTGG
ATACAACATTATGCTTTGATAAAGAAAGCCTAGATCTTGCATTTAAGTACTTTATGTCACCTACTTTGACTATGAGGTTGGCTGGATTGA
GTCAGATAACAAATCAACTCCATACCTTCAATGATGTGTGCAATAATGAATCATTAGTATCGGACACAGAAACGTCCATTGCAAAAGAAC
TTGCAGACTGGCTTATTAGCAACAATGTGGTGGAGCATATATTTGGACCAAATTTACATATTGAGATTATCAAACAGTGCCAAGTGATTT
TGAATTTTTTGGCAGCAGAAGGGCGACTGAGTACTCAACATATTGACTGTATTTGGGCTGCAGCACAGTTGAAACATTGTAGTCGGTATA
TACATGACTTATTTCCTTCACTCATCAAGAATTTGGATCCCGTACCACTTAGACATCTACTTAATCTGGTCTCAGCTCTTGAGCCAAGTG
TTCATACTGAACAGACACTGTACTTGGCATCCATGTTAATTAAAGCACTGTGGAATAACGCACTAGCAGCTAAGGCTCAGTTATCTAAAC
AGAGTTCTTTTGCATCTTTATTAAATACTAATATTCCCATTGGAAATAAGAAAGAGGAAGAAGAGCTTAGAAGAACAGCTCCATCACCTT
GGTCACCTGCAGCTAGTCCTCAAAGCAGTGATAATAGCGATACACATCAAAGTGGAGGTAGTGACATTGAAATGGATGAGCAACTTATTA
ATAGAACCAAACATGTGCAACAACGACTTTCAGACACAGAGGAATCCATGCAGGGAAGTTCTGACGAAACTGCCAACAGTGGTGAAGATG
GAAGCAGTGGTCCTGGTAGCAGTAGTGGGCATAGTGATGGATCTAGCAATGAGGTTAATTCTAGCCACGCAAGCCAGTCAGCTGGGAGCC
CTGGCAGTGAGGTACAGTCAGAAGACATTGCAGATATTGAAGCCCTCAAAGAGGAAGATGAAGACGATGATCATGGTCATAATCCTCCCA
AAAGCAGTTGTGGTACAGATCTTCGGAATAGAAAGTTAGAGAGTCAAGCAGGCATTTGCCTGGGGGACTCCCAAGGCATGTCAGAAAGAA
ATGGGACAAGCAGCGGAACAGGAAAGGACCTGGTTTTTAACACTGAATCATTGCCATCAGTAGATAATCGAATGCGAATGCTGGATGCTT
GTTCACACTCTGAAGACCCAGAACATGATATTTCAGGGGAAATGAATGCTACTCATATAGCACAAGGGTCTCAGGAGTCTTGTATCACAC
GAACTGGGGACTTCCTTGGGGAGACTATTGGGAATGAATTATTTAATTGTCGACAATTTATTGGTCCACAGCATCACCACCACCACCACC
ACCATCACCACCACCACGATGGGCATATGGTTGATGATATGCTAAGTGCAGATGATGTCAGTTGTAGTAGCTCCCAGGTTAGTGCAAAAT
CAGAAAAAAATATGGCTGATTTTGATGGTGAAGAATCTGGATGTGAAGAGGAGCTAGTTCAGATTAATTCACATGCGGAACTGACATCTC
ACCTCCAACAACATCTTCCCAATTTAGCTTCCATTTACCATGAACATCTTAGTCAAGGACCTGTAGTTCATAAACATCAATTCAACAGTA
ATGCTGTTACAGACATTAATTTGGATAATGTTTGCAAGAAAGGAAATACTTTGTTGTGGGATATAGTCCAAGATGAAGATGCAGTTAATC
TTTCTGAAGGATTAATAAATGAAGCAGAGAAACTTCTTTGTTCGTTAGTATGTTGGTTTACAGATAGACAAATTCGAATGAGATTCATTG
AAGGTTGCCTTGAAAACTTGGGAAACAACAGATCAGTAGTAATTTCACTTCGTCTTCTTCCAAAACTATTTGGTACTTTTCAGCAGTTTG
GGAGCAGTTACGATACACACTGGATAACAATGTGGGCAGAAAAAGAACTGAACATGATGAAGCTTTTCTTTGATAATTTGGTATACTACA
TTCAAACTGTGAGAGAAGGAAGACAAAAACATGCACTGTACAGCCATAGTGCTGAAGTTCAAGTTCGTCTTCAATTCTTGACTTGTGTAT
TTTCAACTCTGGGATCACCTGATCATTTCAGGTTAAGTTTAGAGCAAGTTGACATCTTATGGCATTGTTTAGTAGAAGATTCTGAATGTT
ATGATGATGCACTCCATTGGTTTTTAAATCAAGTTCGAAGTAAAGATCAACATGCTATGGGTATGGAAACCTACAAACATCTTTTCCTGG
AGAAGATGCCCCAGCTAAAACCTGAAACAATTAGCATGACTGGCTTAAACCTGTTTCAGCATCTCTGTAACTTGGCTCGATTGGCTACCA
GTGCCTATGATGGTTGTTCAAATTCTGAGCTGTGTGGTATGGACCAATTTTGGGGCATTGCTTTAAGAGCACAATCTGGTGATGTCAGTC
GAGCAGCTATCCAGTATATTAACTCCTATTATATTAATGGTAAAACAGGTTTGGAGAAGGAGCAAGAATTTATTAGTAAGTGCATGGAGA
GTCTTATGATAGCTTCTAGCAGTCTTGAACAGGAATCACACTCAAGTCTCATGGTTATAGAAAGAGGACTCCTTATGCTGAAGACACATC
TGGAAGCGTTTAGGAGAAGGTTTGCATATCATCTGAGACAGTGGCAAATTGAAGGCACTGGTATTAGTAGTCATTTGAAAGCACTGAGTG
ACAAACAGTCTCTGCCGCTAAGGGTTGTATGCCAGCCAGCTGGACTTCCTGACAAGATGACTATTGAAATGTATCCTAGTGACCAGGTAG
CAGATCTTAGGGCTGAAGTAACTCATTGGTATGAAAATTTACAGAAAGAACAAATAAATCAACAAGCTCAGCTTCAGGAGTTTGGTCAAA
GCAACCGAAAAGGAGAGTTTCCTGGAGGCCTCATGGGACCTGTCAGGATGATTTCATCTGGACACGAGTTAACAACAGATTATGATGAAA
AAGCACTTCATGAGCTTGGTTTTAAGGATATGCAGATGGTATTTGTATCTTTGGGTGCACCAAGGAGAGAGCGGAAAGGGGAAGGTGTTC
AGCTGCCAGCATCTTGCCTCCCACCCCCTCAGAAGGACAACATTCCAATGCTTTTGCTTTTACAAGAGCCTCATTTAACTACTCTTTTTG
ATTTATTAGAGATGCTTGCATCATTTAAACCACCCTCAGGAAAAGTGGCAGTGGATGATAGTGAGAGCTTACGATGTGAAGAACTTCATC
TTCATGCAGAAAATCTGTCTAGGCGGGTCTGGGAGCTACTGATGCTTCTTCCTACATGTCCTAATATGTTGATGGCATTCCAGAATATCT
CAGATGAGCAGAGTAATGATGGATTTAATTGGAAAGAACTTCTCAAAATTAAGAGCGCCCACAAGCTATTGTATGCTCTGGAAATTATTG
AAGCACTGGGAAAACCTAATAGAAGAATAAGGAGGGAGTCTACGGGAAGTTACAGTGATCTTTATCCAGATTCAGATGATTCAAGTGAAG
ATCAAGTGGAAAATAGTAAAAATTCCTGGAGTTGCAAGTTTGTTGCTGCTGGAGGGCTTCAACAGTTATTAGAAATTTTTAATTCTGGAA
TTCTAGAGCCTAAAGAGCAGGAATCATGGACTGTGTGGCAGCTAGACTGTCTTGCTTGCTTGCTGAAGTTAATATGCCAGTTTGCAGTAG
ATCCATCCGATTTGGATTTAGCTTATCATGATGTCTTTGCCTGGTCTGGTATAGCGGAAAGCCATAGGAAAAGAACCTGGCCTGGCAAAT
CAAGGAAGGCTGCTGGTGATCATGCTAAGGGTCTTCATATACCACGATTAACAGAGGTATTTCTTGTTCTTGTCCAAGGAACCAGTTTGA
TTCAGCGACTTATGTCTGTTGCTTATACGTATGATAATCTGGCTCCTAGAGTTTTAAAAGCTCAGTCTGATCACAGGTCTAGACATGAAG
TTTCACATTATTCAATGTGGCTCTTGGTGAGTTGGGCTCATTGCTGTTCTTTAGTGAAATCTAGCCTTGCTGATAGCGATCATTTACAAG
ATTGGCTAAAGAAATTGACTCTCCTTATTCCTGAGACTGCAGTTCGTCATGAATCATGCAGTGGTCTCTATAAGTTATCCCTGTCAGGGC
TGGATGGAGGAGACTCAATCAATCGTTCTTTTCTGCTATTGGCTGCCTCAACATTATTGAAATTTCTTCCTGATGCTCAAGCACTCAAAC
CTATTAGGATAGATGATTATGAGGAAGAACCAATATTAAAACCAGGATGTAAAGAGTATTTTTGGTTGTTATGCAAATTAGTTGACAACA
TACATATAAAGGACGCTAGTCAGACAACGCTCCTCGACTTAGATGCCTTGGCAAGACATTTGGCTGACTGTATTCGAAGTAGGGAGATCC
TTGATCATCAGGATGGTAATGTAGAAGATGATGGGCTTACAGGACTCCTAAGGCTTGCAACAAGTGTTGTTAAACACAAACCACCCTTTA
AATTTTCAAGGGAAGGACAGAATTCAGATCAGGAAGGAGGTGGAAAGAAAAAGAAGAAAAAGAAGGACAAGAAACACAAAAAGGATAAGA
AGCACAAGAAGCACAAAAAACACAAGAAGGAAAAGGCTGTGGCTGCAGCTGCTGCAGCTGCTGTGACCCCTGCAGCCATTGCAGCTGCCA
CAACCACATTAGCACAGGAAGAGCCAGTGGCAGCGCCAGAGCCGAAGAAGGAGACTGAAAGTGAAGCTGAAGATAACCTTGATGATTTAG
AAAAGCACCTGCGTGAAAAGGCCCTGAGATCAATGAGGAAGGCCCAAGTGTCCCCACAGTCTTAGGGGGAAATGTTTGTTATGATGTAAA
TTTTATTTGGTTTGTACGCAGTTCAATTTCAAAATTGCTAAAATGTGTTTGAGCTTTAGACTATAACATTTGTTGTAATAATTGCTAGGT
TGAAGTTCAACATGTAAAAAAAGGGGGCATGGATTTACATTGCAAAAGGTGTCCACAGTGTATTAGTGACATTCTTTCATTGACAGCTGA
CATAATTCATTGAGTGAAATATTTTAAGCCAAAAAAAAATTCCCTTTTTAAAAAAGGGGGTTTAAATACTGTTGGCATTTTTATGGTTCC

>97413_97413_3_USP34-SRRM1_USP34_chr2_61505300_ENST00000398571_SRRM1_chr1_24997877_ENST00000447431_length(amino acids)=1915AA_BP=1811
MCENCADLVEVLNEISDVEGGDGLQLRKEHTLKIFTYINSWTQRQCLCCFKEYKHLEIFNQVVCALINLVIAQVQVLRDQLCKHCTTINI
DSTWQDESNQAEEPLNIDRECNEGSTERQKSIEKKSNSTRICNLTEEESSKSSDPFSLWSTDEKEKLLLCVAKIFQIQFPLYTAYKHNTH
PTIEDISTQESNILGAFCDMNDVEVPLHLLRYVCLFCGKNGLSLMKDCFEYGTPETLPFLIAHAFITVVSNIRIWLHIPAVMQHIIPFRT
YVIRYLCKLSDQELRQSAARNMADLMWSTVKEPLDTTLCFDKESLDLAFKYFMSPTLTMRLAGLSQITNQLHTFNDVCNNESLVSDTETS
IAKELADWLISNNVVEHIFGPNLHIEIIKQCQVILNFLAAEGRLSTQHIDCIWAAAQLKHCSRYIHDLFPSLIKNLDPVPLRHLLNLVSA
LEPSVHTEQTLYLASMLIKALWNNALAAKAQLSKQSSFASLLNTNIPIGNKKEEEELRRTAPSPWSPAASPQSSDNSDTHQSGGSDIEMD
EQLINRTKHVQQRLSDTEESMQGSSDETANSGEDGSSGPGSSSGHSDGSSNEVNSSHASQSAGSPGSEVQSEDIADIEALKEEDEDDDHG
HNPPKSSCGTDLRNRKLESQAGICLGDSQGMSERNGTSSGTGKDLVFNTESLPSVDNRMRMLDACSHSEDPEHDISGEMNATHIAQGSQE
SCITRTGDFLGETIGNELFNCRQFIGPQHHHHHHHHHHHHDGHMVDDMLSADDVSCSSSQVSAKSEKNMADFDGEESGCEEELVQINSHA
ELTSHLQQHLPNLASIYHEHLSQGPVVHKHQFNSNAVTDINLDNVCKKGNTLLWDIVQDEDAVNLSEGLINEAEKLLCSLVCWFTDRQIR
MRFIEGCLENLGNNRSVVISLRLLPKLFGTFQQFGSSYDTHWITMWAEKELNMMKLFFDNLVYYIQTVREGRQKHALYSHSAEVQVRLQF
LTCVFSTLGSPDHFRLSLEQVDILWHCLVEDSECYDDALHWFLNQVRSKDQHAMGMETYKHLFLEKMPQLKPETISMTGLNLFQHLCNLA
RLATSAYDGCSNSELCGMDQFWGIALRAQSGDVSRAAIQYINSYYINGKTGLEKEQEFISKCMESLMIASSSLEQESHSSLMVIERGLLM
LKTHLEAFRRRFAYHLRQWQIEGTGISSHLKALSDKQSLPLRVVCQPAGLPDKMTIEMYPSDQVADLRAEVTHWYENLQKEQINQQAQLQ
EFGQSNRKGEFPGGLMGPVRMISSGHELTTDYDEKALHELGFKDMQMVFVSLGAPRRERKGEGVQLPASCLPPPQKDNIPMLLLLQEPHL
TTLFDLLEMLASFKPPSGKVAVDDSESLRCEELHLHAENLSRRVWELLMLLPTCPNMLMAFQNISDEQSNDGFNWKELLKIKSAHKLLYA
LEIIEALGKPNRRIRRESTGSYSDLYPDSDDSSEDQVENSKNSWSCKFVAAGGLQQLLEIFNSGILEPKEQESWTVWQLDCLACLLKLIC
QFAVDPSDLDLAYHDVFAWSGIAESHRKRTWPGKSRKAAGDHAKGLHIPRLTEVFLVLVQGTSLIQRLMSVAYTYDNLAPRVLKAQSDHR
SRHEVSHYSMWLLVSWAHCCSLVKSSLADSDHLQDWLKKLTLLIPETAVRHESCSGLYKLSLSGLDGGDSINRSFLLLAASTLLKFLPDA
QALKPIRIDDYEEEPILKPGCKEYFWLLCKLVDNIHIKDASQTTLLDLDALARHLADCIRSREILDHQDGNVEDDGLTGLLRLATSVVKH
KPPFKFSREGQNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEPKKETESEAEDN

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Fusion Gene PPI Analysis for USP34-SRRM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP34-SRRM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP34-SRRM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource