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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP39-REEP1 (FusionGDB2 ID:97454)

Fusion Gene Summary for USP39-REEP1

check button Fusion gene summary
Fusion gene informationFusion gene name: USP39-REEP1
Fusion gene ID: 97454
HgeneTgene
Gene symbol

USP39

REEP1

Gene ID

10713

65055

Gene nameubiquitin specific peptidase 39receptor accessory protein 1
Synonyms65K|CGI-21|HSPC332|SAD1|SNRNP65C2orf23|HMN5B|SPG31|Yip2a
Cytomap

2p11.2

2p11.2

Type of geneprotein-codingprotein-coding
DescriptionU4/U6.U5 tri-snRNP-associated protein 2SAD1 homologSnRNP assembly defective 1 homologU4/U6.U5 tri-snRNP-associated 65 kDa proteininactive ubiquitin-specific peptidase 39small nuclear ribonucleoprotein 65kDa (U4/U6.U5)ubiquitin specific protease 39receptor expression-enhancing protein 1spastic paraplegia 31 protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000459775, ENST00000323701, 
ENST00000409025, ENST00000409470, 
ENST00000409766, ENST00000450066, 
ENST00000165698, ENST00000473407, 
ENST00000540790, ENST00000535845, 
ENST00000538924, ENST00000541910, 
Fusion gene scores* DoF score11 X 11 X 8=9689 X 5 X 8=360
# samples 169
** MAII scorelog2(16/968*10)=-2.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP39 [Title/Abstract] AND REEP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP39(85846412)-REEP1(86509365), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP39

GO:0000398

mRNA splicing, via spliceosome

11350945

TgeneREEP1

GO:0051205

protein insertion into membrane

15550249


check buttonFusion gene breakpoints across USP39 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across REEP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A2GP-06AUSP39chr2

85846412

-REEP1chr2

86509365

-
ChimerDB4SKCMTCGA-EE-A2GP-06AUSP39chr2

85846412

+REEP1chr2

86509365

-
ChimerDB4SKCMTCGA-EE-A2GPUSP39chr2

85846412

+REEP1chr2

86509365

-


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Fusion Gene ORF analysis for USP39-REEP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000459775ENST00000165698USP39chr2

85846412

+REEP1chr2

86509365

-
3UTR-5UTRENST00000459775ENST00000473407USP39chr2

85846412

+REEP1chr2

86509365

-
3UTR-5UTRENST00000459775ENST00000540790USP39chr2

85846412

+REEP1chr2

86509365

-
3UTR-intronENST00000459775ENST00000535845USP39chr2

85846412

+REEP1chr2

86509365

-
3UTR-intronENST00000459775ENST00000538924USP39chr2

85846412

+REEP1chr2

86509365

-
3UTR-intronENST00000459775ENST00000541910USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-5UTRENST00000323701ENST00000473407USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-5UTRENST00000323701ENST00000540790USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-5UTRENST00000409025ENST00000473407USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-5UTRENST00000409025ENST00000540790USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-5UTRENST00000409470ENST00000473407USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-5UTRENST00000409470ENST00000540790USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-5UTRENST00000409766ENST00000473407USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-5UTRENST00000409766ENST00000540790USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-5UTRENST00000450066ENST00000473407USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-5UTRENST00000450066ENST00000540790USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000323701ENST00000535845USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000323701ENST00000538924USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000323701ENST00000541910USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000409025ENST00000535845USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000409025ENST00000538924USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000409025ENST00000541910USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000409470ENST00000535845USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000409470ENST00000538924USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000409470ENST00000541910USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000409766ENST00000535845USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000409766ENST00000538924USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000409766ENST00000541910USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000450066ENST00000535845USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000450066ENST00000538924USP39chr2

85846412

+REEP1chr2

86509365

-
5CDS-intronENST00000450066ENST00000541910USP39chr2

85846412

+REEP1chr2

86509365

-
In-frameENST00000323701ENST00000165698USP39chr2

85846412

+REEP1chr2

86509365

-
In-frameENST00000409025ENST00000165698USP39chr2

85846412

+REEP1chr2

86509365

-
In-frameENST00000409470ENST00000165698USP39chr2

85846412

+REEP1chr2

86509365

-
In-frameENST00000409766ENST00000165698USP39chr2

85846412

+REEP1chr2

86509365

-
In-frameENST00000450066ENST00000165698USP39chr2

85846412

+REEP1chr2

86509365

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000450066USP39chr285846412+ENST00000165698REEP1chr286509365-4006325221898225
ENST00000409025USP39chr285846412+ENST00000165698REEP1chr286509365-407239123964313
ENST00000409470USP39chr285846412+ENST00000165698REEP1chr286509365-404636527938303
ENST00000323701USP39chr285846412+ENST00000165698REEP1chr286509365-402934810921303
ENST00000409766USP39chr285846412+ENST00000165698REEP1chr286509365-40213402913303

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000450066ENST00000165698USP39chr285846412+REEP1chr286509365-0.0044077580.9955922
ENST00000409025ENST00000165698USP39chr285846412+REEP1chr286509365-0.0008901910.9991098
ENST00000409470ENST00000165698USP39chr285846412+REEP1chr286509365-0.0008750110.99912494
ENST00000323701ENST00000165698USP39chr285846412+REEP1chr286509365-0.0008750140.99912494
ENST00000409766ENST00000165698USP39chr285846412+REEP1chr286509365-0.0008791550.9991209

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Fusion Genomic Features for USP39-REEP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP39-REEP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:85846412/chr2:86509365)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP39chr2:85846412chr2:86509365ENST00000323701+2134_103112566.0Compositional biasNote=Arg-rich
HgeneUSP39chr2:85846412chr2:86509365ENST00000409470+2144_103112555.6666666666666Compositional biasNote=Arg-rich
HgeneUSP39chr2:85846412chr2:86509365ENST00000409766+2124_103112571.3333333333334Compositional biasNote=Arg-rich
TgeneREEP1chr2:85846412chr2:86509365ENST0000016569807170_17310202.0Compositional biasNote=Poly-Pro
TgeneREEP1chr2:85846412chr2:86509365ENST0000053584506170_1730175.0Compositional biasNote=Poly-Pro
TgeneREEP1chr2:85846412chr2:86509365ENST0000053892407170_17317209.0Compositional biasNote=Poly-Pro
TgeneREEP1chr2:85846412chr2:86509365ENST0000054191005170_17310144.0Compositional biasNote=Poly-Pro
TgeneREEP1chr2:85846412chr2:86509365ENST000001656980735_5510202.0TransmembraneHelical
TgeneREEP1chr2:85846412chr2:86509365ENST00000535845061_210175.0TransmembraneHelical
TgeneREEP1chr2:85846412chr2:86509365ENST000005358450635_550175.0TransmembraneHelical
TgeneREEP1chr2:85846412chr2:86509365ENST000005389240735_5517209.0TransmembraneHelical
TgeneREEP1chr2:85846412chr2:86509365ENST000005419100535_5510144.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP39chr2:85846412chr2:86509365ENST00000450066+2124_10334463.0Compositional biasNote=Arg-rich
HgeneUSP39chr2:85846412chr2:86509365ENST00000323701+213225_555112566.0DomainNote=USP
HgeneUSP39chr2:85846412chr2:86509365ENST00000409470+214225_555112555.6666666666666DomainNote=USP
HgeneUSP39chr2:85846412chr2:86509365ENST00000409766+212225_555112571.3333333333334DomainNote=USP
HgeneUSP39chr2:85846412chr2:86509365ENST00000450066+212225_55534463.0DomainNote=USP
HgeneUSP39chr2:85846412chr2:86509365ENST00000323701+213122_183112566.0Zinc fingerUBP-type
HgeneUSP39chr2:85846412chr2:86509365ENST00000409470+214122_183112555.6666666666666Zinc fingerUBP-type
HgeneUSP39chr2:85846412chr2:86509365ENST00000409766+212122_183112571.3333333333334Zinc fingerUBP-type
HgeneUSP39chr2:85846412chr2:86509365ENST00000450066+212122_18334463.0Zinc fingerUBP-type
TgeneREEP1chr2:85846412chr2:86509365ENST00000165698071_2110202.0TransmembraneHelical
TgeneREEP1chr2:85846412chr2:86509365ENST00000538924071_2117209.0TransmembraneHelical
TgeneREEP1chr2:85846412chr2:86509365ENST00000541910051_2110144.0TransmembraneHelical


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Fusion Gene Sequence for USP39-REEP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97454_97454_1_USP39-REEP1_USP39_chr2_85846412_ENST00000323701_REEP1_chr2_86509365_ENST00000165698_length(transcript)=4029nt_BP=348nt
GGTAGTGGAGATGTCCGGCCGGTCTAAGCGGGAGTCTCGCGGTTCCACTCGCGGGAAGCGAGAGTCTGAGTCGCGGGGCAGCTCCGGTCG
CGTCAAGCGGGAGCGAGATCGGGAGCGGGAGCCTGAGGCGGCGAGCTCCCGGGGCAGCCCTGTGCGCGTGAAGCGGGAGTTCGAGCCGGC
GAGCGCGCGCGAGGCCCCGGCTTCTGTTGTCCCGTTTGTGCGGGTGAAGCGGGAGCGCGAGGTCGATGAGGACTCGGAGCCTGAGCGGGA
GGTGCGAGCAAAGAATGGCCGAGTGGATTCTGAGGACCGGAGGAGCCGCCACTGCCCGTACCTGGACACCATTAACAGGCTTATATTTGG
CACCCTTTACCCTGCGTATTATTCCTACAAGGCTGTGAAATCAAAGGACATTAAGGAATATGTCAAATGGATGATGTACTGGATTATATT
TGCACTTTTCACCACAGCAGAGACATTCACAGACATCTTCCTTTGTTGGTTTCCATTCTATTATGAACTAAAAATAGCATTTGTAGCCTG
GCTGCTGTCTCCCTACACAAAAGGCTCCAGCCTCCTGTACAGGAAGTTTGTACATCCCACGCTATCTTCAAAAGAAAAGGAAATCGATGA
TTGTCTGGTCCAAGCAAAAGACCGAAGTTACGATGCCCTTGTGCACTTCGGGAAGCGGGGCTTGAACGTGGCCGCCACAGCGGCTGTGAT
GGCTGCTTCCAAGGGACAGGGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCC
TGCTCCCTCGGGCCCCCCACCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGC
TAGCAGCTCAGGCACCGCCTAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGAT
GAGCCAACAGCACCGGATCCACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCT
TTGAGTGTGCAGCCTCACAAACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTG
GGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATT
ATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGT
TTTTAGTCCTGTAAATGCAAACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGG
CTTTTGGCTTTTAATATAATGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTT
GATTCTAGAGAACGTCTCAGATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATAT
TCTTTAGATAGTTGTTTAGTCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTC
AGGGGAACATCCCAGTAAAAGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGA
TAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACG
ATTTCTCCTTTATCGTGACCAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACT
TGTTTAGCTTAGCAAAAACAAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAAC
AATCAAAATGGTGGGCTCTAGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCA
CACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACA
AGCCTGGATTGCTTAGTAGGGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAA
ATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTC
TTTCAGTGTAATGCATGCAGTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAA
TTAGTGTTATATACCATATAGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTA
GAGGCCTTTGCTGATGACACATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGG
AATCCCATCTACCCATAGTTCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGA
GAGGATAAACAGAAGCTGTTTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTG
TGCTCATTGAGTAGTTCCAGACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACG
AATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGC
AGTTTAAAATCCTATCGTGAACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAAC
TATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAAC
TCTGTCTTAATGTAAATGTAACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAA
GCAGCTGTCATATTTCTGGCAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAA
GTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAAT
GCTAGCTGGAAAGTCTGTAATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTG
CTTATAAACTGGAGAGTTTAGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTG
ATAAGCTATCCATGTGTTTGTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAA
ATGGCAAAGGATGTGCTTCATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATG
TCTGTAGTCCCTATAGAATGATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAA

>97454_97454_1_USP39-REEP1_USP39_chr2_85846412_ENST00000323701_REEP1_chr2_86509365_ENST00000165698_length(amino acids)=303AA_BP=112
MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAREAPASVVPFVRVKREREVDEDSEPEREVRA
KNGRVDSEDRRSRHCPYLDTINRLIFGTLYPAYYSYKAVKSKDIKEYVKWMMYWIIFALFTTAETFTDIFLCWFPFYYELKIAFVAWLLS
PYTKGSSLLYRKFVHPTLSSKEKEIDDCLVQAKDRSYDALVHFGKRGLNVAATAAVMAASKGQGALSERLRSFSMQDLTTIRGDGAPAPS

--------------------------------------------------------------
>97454_97454_2_USP39-REEP1_USP39_chr2_85846412_ENST00000409025_REEP1_chr2_86509365_ENST00000165698_length(transcript)=4072nt_BP=391nt
GCGCGCTCGAGCGTGCTTGGCGCCTGCGCTGGACGACTCGGCCGGTAGTGGAGATGTCCGGCCGGTCTAAGCGGGAGTCTCGCGGTTCCA
CTCGCGGGAAGCGAGAGTCTGAGTCGCGGGGCAGCTCCGGTCGCGTCAAGCGGGAGCGAGATCGGGAGCGGGAGCCTGAGGCGGCGAGCT
CCCGGGGCAGCCCTGTGCGCGTGAAGCGGGAGTTCGAGCCGGCGAGCGCGCGCGAGGCCCCGGCTTCTGTTGTCCCGTTTGTGCGGGTGA
AGCGGGAGCGCGAGGTCGATGAGGACTCGGAGCCTGAGCGGGAGGTGCGAGCAAAGAATGGCCGAGTGGATTCTGAGGACCGGAGGAGCC
GCCACTGCCCGTACCTGGACACCATTAACAGGCTTATATTTGGCACCCTTTACCCTGCGTATTATTCCTACAAGGCTGTGAAATCAAAGG
ACATTAAGGAATATGTCAAATGGATGATGTACTGGATTATATTTGCACTTTTCACCACAGCAGAGACATTCACAGACATCTTCCTTTGTT
GGTTTCCATTCTATTATGAACTAAAAATAGCATTTGTAGCCTGGCTGCTGTCTCCCTACACAAAAGGCTCCAGCCTCCTGTACAGGAAGT
TTGTACATCCCACGCTATCTTCAAAAGAAAAGGAAATCGATGATTGTCTGGTCCAAGCAAAAGACCGAAGTTACGATGCCCTTGTGCACT
TCGGGAAGCGGGGCTTGAACGTGGCCGCCACAGCGGCTGTGATGGCTGCTTCCAAGGGACAGGGTGCCTTATCGGAGAGACTGCGGAGCT
TCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTGGGCGGGCCAGCGGCA
AACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCCTAGAATCCTTCGATCTCGCTTCAGGAAG
AAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTTCTCTGCCTTAAAG
AGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCTCTCTCCCCTTCCA
CTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGGGGTGGTGACCTTT
AAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAGAATCACCCCTATG
CTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTTACAACTTTCTTTG
TTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGCTGCCAGAGGTTCT
GATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAGCTTCCAAATACAA
CTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACAAGTTACAAACTAA
GAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAGGAAGCTCATCTCC
TCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTGAGGATGGGAACAT
GTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTTCCTGACAGAGGAG
CTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAACTGAGAACTCTGCT
GTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAGCTCGAGATCTTCA
TGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATGTAAACAGCAGACT
CATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTCTCTGAGGGGGCTT
TCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCACTGAGAGCTGAGC
CGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAGTTACTCATAATAT
TTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAGTCAACTATAAACA
GGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTTAGCCACCCCAGAA
AGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGATTTTGTAATTTGCA
AAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGTGCCCCACACCCAC
CAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATATACTCTTTAAAAT
GTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTACACAGCTTCTTAGC
AATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTTCGCCATTTTACAA
TGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCAGACATGCTGTATT
ATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTCAAGTGTTGACTAG
GGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACGTATCTGACAAGTT
GTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAGGATACAACTGAAT
GTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAACTTTTAGTTAATT
GCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCCTGGCTTTGTGTGA
ATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTTGTCAACCATGACC
ATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGTACACTCCCAGAGC
TGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAATAGTATACTGGACT
GTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACACATCTTGAATAAAGTC

>97454_97454_2_USP39-REEP1_USP39_chr2_85846412_ENST00000409025_REEP1_chr2_86509365_ENST00000165698_length(amino acids)=313AA_BP=122
MRWTTRPVVEMSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAREAPASVVPFVRVKREREVDE
DSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRLIFGTLYPAYYSYKAVKSKDIKEYVKWMMYWIIFALFTTAETFTDIFLCWFPFYYEL
KIAFVAWLLSPYTKGSSLLYRKFVHPTLSSKEKEIDDCLVQAKDRSYDALVHFGKRGLNVAATAAVMAASKGQGALSERLRSFSMQDLTT

--------------------------------------------------------------
>97454_97454_3_USP39-REEP1_USP39_chr2_85846412_ENST00000409470_REEP1_chr2_86509365_ENST00000165698_length(transcript)=4046nt_BP=365nt
CGCTGGACGACTCGGCCGGTAGTGGAGATGTCCGGCCGGTCTAAGCGGGAGTCTCGCGGTTCCACTCGCGGGAAGCGAGAGTCTGAGTCG
CGGGGCAGCTCCGGTCGCGTCAAGCGGGAGCGAGATCGGGAGCGGGAGCCTGAGGCGGCGAGCTCCCGGGGCAGCCCTGTGCGCGTGAAG
CGGGAGTTCGAGCCGGCGAGCGCGCGCGAGGCCCCGGCTTCTGTTGTCCCGTTTGTGCGGGTGAAGCGGGAGCGCGAGGTCGATGAGGAC
TCGGAGCCTGAGCGGGAGGTGCGAGCAAAGAATGGCCGAGTGGATTCTGAGGACCGGAGGAGCCGCCACTGCCCGTACCTGGACACCATT
AACAGGCTTATATTTGGCACCCTTTACCCTGCGTATTATTCCTACAAGGCTGTGAAATCAAAGGACATTAAGGAATATGTCAAATGGATG
ATGTACTGGATTATATTTGCACTTTTCACCACAGCAGAGACATTCACAGACATCTTCCTTTGTTGGTTTCCATTCTATTATGAACTAAAA
ATAGCATTTGTAGCCTGGCTGCTGTCTCCCTACACAAAAGGCTCCAGCCTCCTGTACAGGAAGTTTGTACATCCCACGCTATCTTCAAAA
GAAAAGGAAATCGATGATTGTCTGGTCCAAGCAAAAGACCGAAGTTACGATGCCCTTGTGCACTTCGGGAAGCGGGGCTTGAACGTGGCC
GCCACAGCGGCTGTGATGGCTGCTTCCAAGGGACAGGGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATC
AGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGG
AGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCCTAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGA
AACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATC
CGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCC
TTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCC
ACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTA
TCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTAT
GATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAA
ATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGC
AGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTA
AAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTC
TGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCT
GTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAG
CGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATC
TGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCA
GGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTT
ATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTG
AAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTG
CTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATG
CCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTAC
TACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTG
CCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAA
AGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGAC
AGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACC
CAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAAT
AAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTA
TCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAA
TATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACAC
TCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAA
AATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACA
CAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGG
TGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTT
GAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCAC
CTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCAC
ATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACA

>97454_97454_3_USP39-REEP1_USP39_chr2_85846412_ENST00000409470_REEP1_chr2_86509365_ENST00000165698_length(amino acids)=303AA_BP=112
MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAREAPASVVPFVRVKREREVDEDSEPEREVRA
KNGRVDSEDRRSRHCPYLDTINRLIFGTLYPAYYSYKAVKSKDIKEYVKWMMYWIIFALFTTAETFTDIFLCWFPFYYELKIAFVAWLLS
PYTKGSSLLYRKFVHPTLSSKEKEIDDCLVQAKDRSYDALVHFGKRGLNVAATAAVMAASKGQGALSERLRSFSMQDLTTIRGDGAPAPS

--------------------------------------------------------------
>97454_97454_4_USP39-REEP1_USP39_chr2_85846412_ENST00000409766_REEP1_chr2_86509365_ENST00000165698_length(transcript)=4021nt_BP=340nt
AGATGTCCGGCCGGTCTAAGCGGGAGTCTCGCGGTTCCACTCGCGGGAAGCGAGAGTCTGAGTCGCGGGGCAGCTCCGGTCGCGTCAAGC
GGGAGCGAGATCGGGAGCGGGAGCCTGAGGCGGCGAGCTCCCGGGGCAGCCCTGTGCGCGTGAAGCGGGAGTTCGAGCCGGCGAGCGCGC
GCGAGGCCCCGGCTTCTGTTGTCCCGTTTGTGCGGGTGAAGCGGGAGCGCGAGGTCGATGAGGACTCGGAGCCTGAGCGGGAGGTGCGAG
CAAAGAATGGCCGAGTGGATTCTGAGGACCGGAGGAGCCGCCACTGCCCGTACCTGGACACCATTAACAGGCTTATATTTGGCACCCTTT
ACCCTGCGTATTATTCCTACAAGGCTGTGAAATCAAAGGACATTAAGGAATATGTCAAATGGATGATGTACTGGATTATATTTGCACTTT
TCACCACAGCAGAGACATTCACAGACATCTTCCTTTGTTGGTTTCCATTCTATTATGAACTAAAAATAGCATTTGTAGCCTGGCTGCTGT
CTCCCTACACAAAAGGCTCCAGCCTCCTGTACAGGAAGTTTGTACATCCCACGCTATCTTCAAAAGAAAAGGAAATCGATGATTGTCTGG
TCCAAGCAAAAGACCGAAGTTACGATGCCCTTGTGCACTTCGGGAAGCGGGGCTTGAACGTGGCCGCCACAGCGGCTGTGATGGCTGCTT
CCAAGGGACAGGGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCT
CGGGCCCCCCACCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCT
CAGGCACCGCCTAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAAC
AGCACCGGATCCACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGT
GCAGCCTCACAAACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGG
CTAAAGGGAAAGGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAG
CAGTGTGTTTTTTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTC
CTGTAAATGCAAACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGC
TTTTAATATAATGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAG
AGAACGTCTCAGATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGA
TAGTTGTTTAGTCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAAC
ATCCCAGTAAAAGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGG
TAGCTCACTCTTGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCC
TTTATCGTGACCAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGC
TTAGCAAAAACAAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAA
TGGTGGGCTCTAGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCT
GTTCCCCTCCTGGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGA
TTGCTTAGTAGGGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATT
GTGGTCCGAGGTAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTG
TAATGCATGCAGTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTT
ATATACCATATAGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTT
TGCTGATGACACATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCAT
CTACCCATAGTTCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAA
ACAGAAGCTGTTTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATT
GAGTAGTTCCAGACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAA
AAAAAAAAAAAAAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAA
ATCCTATCGTGAACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAA
AAAAAGTTTGAAGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTT
AATGTAAATGTAACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGT
CATATTTCTGGCAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACAT
GTAGTGGTGTGGTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTG
GAAAGTCTGTAATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAA
CTGGAGAGTTTAGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTA
TCCATGTGTTTGTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAA
GGATGTGCTTCATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGT
CCCTATAGAATGATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCT

>97454_97454_4_USP39-REEP1_USP39_chr2_85846412_ENST00000409766_REEP1_chr2_86509365_ENST00000165698_length(amino acids)=303AA_BP=112
MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAREAPASVVPFVRVKREREVDEDSEPEREVRA
KNGRVDSEDRRSRHCPYLDTINRLIFGTLYPAYYSYKAVKSKDIKEYVKWMMYWIIFALFTTAETFTDIFLCWFPFYYELKIAFVAWLLS
PYTKGSSLLYRKFVHPTLSSKEKEIDDCLVQAKDRSYDALVHFGKRGLNVAATAAVMAASKGQGALSERLRSFSMQDLTTIRGDGAPAPS

--------------------------------------------------------------
>97454_97454_5_USP39-REEP1_USP39_chr2_85846412_ENST00000450066_REEP1_chr2_86509365_ENST00000165698_length(transcript)=4006nt_BP=325nt
GAGGCCCCGGCCTGGCCAAGCGATGCAGCGCACGGAGTTTTCGGGTCTGGTCGGGTCGGGTGGAGTAGGGTATGCTTGACTTCCACCCCC
CGGACGGAGGGCTTTTGTTTTTGTTTTTTTTTGTTTGTTTTTTCGTAACATATCAATAGGAAACAAGGACTTCGGCTTACAGCTGATACC
AGAACCTTCAGAAAAATGCAAATCATCTATAACACAACTCGATGCTTACGGCGGTGCCTTCCCATCTTTTTTCTGCAAAGAATGGCCGAG
TGGATTCTGAGGACCGGAGGAGCCGCCACTGCCCGTACCTGGACACCATTAACAGGCTTATATTTGGCACCCTTTACCCTGCGTATTATT
CCTACAAGGCTGTGAAATCAAAGGACATTAAGGAATATGTCAAATGGATGATGTACTGGATTATATTTGCACTTTTCACCACAGCAGAGA
CATTCACAGACATCTTCCTTTGTTGGTTTCCATTCTATTATGAACTAAAAATAGCATTTGTAGCCTGGCTGCTGTCTCCCTACACAAAAG
GCTCCAGCCTCCTGTACAGGAAGTTTGTACATCCCACGCTATCTTCAAAAGAAAAGGAAATCGATGATTGTCTGGTCCAAGCAAAAGACC
GAAGTTACGATGCCCTTGTGCACTTCGGGAAGCGGGGCTTGAACGTGGCCGCCACAGCGGCTGTGATGGCTGCTTCCAAGGGACAGGGTG
CCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCAC
CGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCCTAGA
ATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACA
GAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACA
TGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTA
GTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAG
AAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACA
CAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGA
CTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATG
TGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAA
AAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAG
AAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGT
GCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGT
GCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAAC
ACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAA
TGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCC
TGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGA
ATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGC
TGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGG
TCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAA
CTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATT
AGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCT
CTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGC
TCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACA
GAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAA
AAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACA
ACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCG
CTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACT
ATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAA
ATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGT
TCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGT
TCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTC
ATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGA
TAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCC
TCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATC
TGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGC

>97454_97454_5_USP39-REEP1_USP39_chr2_85846412_ENST00000450066_REEP1_chr2_86509365_ENST00000165698_length(amino acids)=225AA_BP=34
MLTAVPSHLFSAKNGRVDSEDRRSRHCPYLDTINRLIFGTLYPAYYSYKAVKSKDIKEYVKWMMYWIIFALFTTAETFTDIFLCWFPFYY
ELKIAFVAWLLSPYTKGSSLLYRKFVHPTLSSKEKEIDDCLVQAKDRSYDALVHFGKRGLNVAATAAVMAASKGQGALSERLRSFSMQDL

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Fusion Gene PPI Analysis for USP39-REEP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP39-REEP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP39-REEP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource