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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:USP39-VAMP8 (FusionGDB2 ID:97458)

Fusion Gene Summary for USP39-VAMP8

Fusion gene summary

Fusion gene information	Fusion gene name: USP39-VAMP8
	Fusion gene ID: 97458
		Hgene	Tgene
	Gene symbol	USP39	VAMP8
	Gene ID	10713	8673
	Gene name	ubiquitin specific peptidase 39	vesicle associated membrane protein 8
	Synonyms	65K\|CGI-21\|HSPC332\|SAD1\|SNRNP65	EDB\|VAMP-8
	Cytomap	2p11.2	2p11.2
	Type of gene	protein-coding	protein-coding
	Description	U4/U6.U5 tri-snRNP-associated protein 2SAD1 homologSnRNP assembly defective 1 homologU4/U6.U5 tri-snRNP-associated 65 kDa proteininactive ubiquitin-specific peptidase 39small nuclear ribonucleoprotein 65kDa (U4/U6.U5)ubiquitin specific protease 39	vesicle-associated membrane protein 8vesicle-associated membrane protein 8 (endobrevin)
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000459775, ENST00000323701, ENST00000409025, ENST00000409470, ENST00000409766, ENST00000450066,	ENST00000263864, ENST00000409760, ENST00000432071,
Fusion gene scores	* DoF score	11 X 11 X 8=968	4 X 5 X 4=80
	# samples	16	5
	** MAII score	log2(16/968*10)=-2.59693514238723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: USP39 [Title/Abstract] AND VAMP8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	USP39(85830204)-VAMP8(85808698), # samples:2 USP39(85852814)-VAMP8(85808699), # samples:2 USP39(85830204)-VAMP8(85808699), # samples:2
Anticipated loss of major functional domain due to fusion event.	USP39-VAMP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	USP39	GO:0000398	mRNA splicing, via spliceosome	11350945
Tgene	VAMP8	GO:0016240	autophagosome membrane docking	25686604
Tgene	VAMP8	GO:1903076	regulation of protein localization to plasma membrane	18570918
Tgene	VAMP8	GO:1903531	negative regulation of secretion by cell	12130530

Fusion gene breakpoints across USP39 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VAMP8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-RC-A6M4-01A	USP39	chr2	85852814	-	VAMP8	chr2	85808699	+
ChimerDB4	LIHC	TCGA-RC-A6M4-01A	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
ChimerDB4	OV	TCGA-13-0801-01A	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
ChimerDB4	OV	TCGA-13-0801-01A	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
ChimerDB4	OV	TCGA-13-0801-01A	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
ChimerDB4	OV	TCGA-13-0801	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
ChimerDB4	OV	TCGA-13-0801	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
ChimerDB4	STAD	TCGA-D7-6519-01A	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
ChimerDB4	STAD	TCGA-D7-6519	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+

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Fusion Gene ORF analysis for USP39-VAMP8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000459775	ENST00000263864	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
3UTR-3CDS	ENST00000459775	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
3UTR-3CDS	ENST00000459775	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
3UTR-3CDS	ENST00000459775	ENST00000409760	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
3UTR-3CDS	ENST00000459775	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
3UTR-3CDS	ENST00000459775	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
3UTR-3CDS	ENST00000459775	ENST00000432071	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
3UTR-3CDS	ENST00000459775	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
3UTR-3CDS	ENST00000459775	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
3UTR-3UTR	ENST00000459775	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
3UTR-3UTR	ENST00000459775	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
3UTR-3UTR	ENST00000459775	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
3UTR-5UTR	ENST00000459775	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
3UTR-5UTR	ENST00000459775	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
3UTR-5UTR	ENST00000459775	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
3UTR-5UTR	ENST00000459775	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
3UTR-5UTR	ENST00000459775	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
3UTR-5UTR	ENST00000459775	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
Frame-shift	ENST00000323701	ENST00000409760	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
Frame-shift	ENST00000323701	ENST00000432071	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
Frame-shift	ENST00000409025	ENST00000409760	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
Frame-shift	ENST00000409025	ENST00000432071	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
Frame-shift	ENST00000409470	ENST00000409760	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
Frame-shift	ENST00000409470	ENST00000432071	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
Frame-shift	ENST00000409766	ENST00000409760	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
Frame-shift	ENST00000409766	ENST00000432071	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
Frame-shift	ENST00000450066	ENST00000409760	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
Frame-shift	ENST00000450066	ENST00000432071	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
In-frame	ENST00000323701	ENST00000263864	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
In-frame	ENST00000409025	ENST00000263864	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
In-frame	ENST00000409470	ENST00000263864	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
In-frame	ENST00000409766	ENST00000263864	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
In-frame	ENST00000450066	ENST00000263864	USP39	chr2	85852814	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000323701	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000323701	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000323701	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000323701	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000323701	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000323701	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000409025	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000409025	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000409025	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000409025	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000409025	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000409025	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000409470	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000409470	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000409470	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000409470	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000409470	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000409470	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000409766	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000409766	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000409766	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000409766	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000409766	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000409766	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000450066	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000450066	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000450066	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000450066	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3CDS	ENST00000450066	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808699	+
intron-3CDS	ENST00000450066	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808698	+
intron-3UTR	ENST00000323701	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000323701	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000323701	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000409025	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000409025	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000409025	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000409470	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000409470	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000409470	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000409766	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000409766	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000409766	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000450066	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000450066	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-3UTR	ENST00000450066	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85808877	+
intron-5UTR	ENST00000323701	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000323701	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000323701	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000323701	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000323701	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000323701	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000409025	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000409025	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000409025	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000409025	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000409025	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000409025	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000409470	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000409470	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000409470	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000409470	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000409470	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000409470	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000409766	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000409766	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000409766	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000409766	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000409766	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000409766	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000450066	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000450066	ENST00000263864	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000450066	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000450066	ENST00000409760	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+
intron-5UTR	ENST00000450066	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85806132	+
intron-5UTR	ENST00000450066	ENST00000432071	USP39	chr2	85830204	+	VAMP8	chr2	85806131	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for USP39-VAMP8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
USP39	chr2	85830204	+	VAMP8	chr2	85806131	+	0.000941072	0.9990589
USP39	chr2	85830204	+	VAMP8	chr2	85806131	+	0.000941072	0.9990589
USP39	chr2	85830204	+	VAMP8	chr2	85808698	+	0.000443617	0.99955636
USP39	chr2	85830204	+	VAMP8	chr2	85808698	+	0.000443617	0.99955636
USP39	chr2	85830204	+	VAMP8	chr2	85808698	+	0.000443617	0.99955636
USP39	chr2	85852814	+	VAMP8	chr2	85808698	+	1.15E-08	1
USP39	chr2	85830204	+	VAMP8	chr2	85806131	+	0.000941072	0.9990589
USP39	chr2	85830204	+	VAMP8	chr2	85806131	+	0.000941072	0.9990589
USP39	chr2	85830204	+	VAMP8	chr2	85808698	+	0.000443617	0.99955636
USP39	chr2	85830204	+	VAMP8	chr2	85808698	+	0.000443617	0.99955636
USP39	chr2	85830204	+	VAMP8	chr2	85808698	+	0.000443617	0.99955636
USP39	chr2	85852814	+	VAMP8	chr2	85808698	+	1.15E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP39-VAMP8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:85830204/chr2:85808698)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

USP39

chr2:85852814

chr2:85808699

ENST00000323701

4_103

241

566.0

Compositional bias

Note=Arg-rich

Hgene

USP39

chr2:85852814

chr2:85808699

ENST00000409470

4_103

241

555.6666666666666

Compositional bias

Note=Arg-rich

Hgene

USP39

chr2:85852814

chr2:85808699

ENST00000409766

4_103

241

571.3333333333334

Compositional bias

Note=Arg-rich

Hgene

USP39

chr2:85852814

chr2:85808699

ENST00000450066

4_103

138

463.0

Compositional bias

Note=Arg-rich

Hgene

USP39

chr2:85852814

chr2:85808699

ENST00000323701

122_183

241

566.0

Zinc finger

UBP-type

Hgene

USP39

chr2:85852814

chr2:85808699

ENST00000409470

122_183

241

555.6666666666666

Zinc finger

UBP-type

Hgene

USP39

chr2:85852814

chr2:85808699

ENST00000409766

122_183

241

571.3333333333334

Zinc finger

UBP-type

Tgene

VAMP8

chr2:85852814

chr2:85808699

ENST00000263864

97_100

101.0

Topological domain

Vesicular

Tgene

VAMP8

chr2:85852814

chr2:85808699

ENST00000263864

76_96

101.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

USP39

chr2:85852814

chr2:85808699

ENST00000323701

225_555

241

566.0

Domain

Note=USP

Hgene

USP39

chr2:85852814

chr2:85808699

ENST00000409470

225_555

241

555.6666666666666

Domain

Note=USP

Hgene

USP39

chr2:85852814

chr2:85808699

ENST00000409766

225_555

241

571.3333333333334

Domain

Note=USP

Hgene

USP39

chr2:85852814

chr2:85808699

ENST00000450066

225_555

138

463.0

Domain

Note=USP

Hgene

USP39

chr2:85852814

chr2:85808699

ENST00000450066

122_183

138

463.0

Zinc finger

UBP-type

Tgene

VAMP8

chr2:85852814

chr2:85808699

ENST00000263864

1_75

101.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for USP39-VAMP8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for USP39-VAMP8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for USP39-VAMP8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for USP39-VAMP8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source