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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP3-B2M (FusionGDB2 ID:97460)

Fusion Gene Summary for USP3-B2M

check button Fusion gene summary
Fusion gene informationFusion gene name: USP3-B2M
Fusion gene ID: 97460
HgeneTgene
Gene symbol

USP3

B2M

Gene ID

9960

567

Gene nameubiquitin specific peptidase 3beta-2-microglobulin
SynonymsSIH003|UBPIMD43
Cytomap

15q22.31

15q21.1

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 3deubiquitinating enzyme 3ubiquitin thioesterase 3ubiquitin thiolesterase 3ubiquitin-specific-processing protease 3beta-2-microglobulinbeta chain of MHC class I moleculesbeta-2-microglobin
Modification date2020031320200329
UniProtAcc.

P61769

Ensembl transtripts involved in fusion geneENST00000380324, ENST00000536001, 
ENST00000540797, ENST00000268049, 
ENST00000539772, ENST00000558218, 
ENST00000558285, ENST00000559711, 
ENST00000559220, ENST00000544417, 
ENST00000558401, ENST00000559916, 
Fusion gene scores* DoF score11 X 8 X 6=52864 X 31 X 17=33728
# samples 1371
** MAII scorelog2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(71/33728*10)=-5.56998393724517
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP3 [Title/Abstract] AND B2M [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP3(63797029)-B2M(45007620), # samples:1
Anticipated loss of major functional domain due to fusion event.USP3-B2M seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
USP3-B2M seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
USP3-B2M seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP3

GO:0016578

histone deubiquitination

17980597

HgeneUSP3

GO:0031647

regulation of protein stability

17980597

TgeneB2M

GO:0002726

positive regulation of T cell cytokine production

24643698

TgeneB2M

GO:0007611

learning or memory

26147761

TgeneB2M

GO:0050680

negative regulation of epithelial cell proliferation

28213472

TgeneB2M

GO:0050768

negative regulation of neurogenesis

26147761

TgeneB2M

GO:0090647

modulation of age-related behavioral decline

26147761

TgeneB2M

GO:1900121

negative regulation of receptor binding

9465039

TgeneB2M

GO:1990000

amyloid fibril formation

28468825

TgeneB2M

GO:2000774

positive regulation of cellular senescence

28213472

TgeneB2M

GO:2000978

negative regulation of forebrain neuron differentiation

26147761


check buttonFusion gene breakpoints across USP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across B2M (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A91EUSP3chr15

63797029

+B2Mchr15

45007620

+


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Fusion Gene ORF analysis for USP3-B2M

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000380324ENST00000559220USP3chr15

63797029

+B2Mchr15

45007620

+
5CDS-intronENST00000536001ENST00000559220USP3chr15

63797029

+B2Mchr15

45007620

+
5CDS-intronENST00000540797ENST00000559220USP3chr15

63797029

+B2Mchr15

45007620

+
5UTR-3CDSENST00000268049ENST00000544417USP3chr15

63797029

+B2Mchr15

45007620

+
5UTR-3CDSENST00000268049ENST00000558401USP3chr15

63797029

+B2Mchr15

45007620

+
5UTR-3CDSENST00000268049ENST00000559916USP3chr15

63797029

+B2Mchr15

45007620

+
5UTR-3CDSENST00000539772ENST00000544417USP3chr15

63797029

+B2Mchr15

45007620

+
5UTR-3CDSENST00000539772ENST00000558401USP3chr15

63797029

+B2Mchr15

45007620

+
5UTR-3CDSENST00000539772ENST00000559916USP3chr15

63797029

+B2Mchr15

45007620

+
5UTR-intronENST00000268049ENST00000559220USP3chr15

63797029

+B2Mchr15

45007620

+
5UTR-intronENST00000539772ENST00000559220USP3chr15

63797029

+B2Mchr15

45007620

+
Frame-shiftENST00000380324ENST00000544417USP3chr15

63797029

+B2Mchr15

45007620

+
Frame-shiftENST00000536001ENST00000544417USP3chr15

63797029

+B2Mchr15

45007620

+
Frame-shiftENST00000540797ENST00000544417USP3chr15

63797029

+B2Mchr15

45007620

+
In-frameENST00000380324ENST00000558401USP3chr15

63797029

+B2Mchr15

45007620

+
In-frameENST00000380324ENST00000559916USP3chr15

63797029

+B2Mchr15

45007620

+
In-frameENST00000536001ENST00000558401USP3chr15

63797029

+B2Mchr15

45007620

+
In-frameENST00000536001ENST00000559916USP3chr15

63797029

+B2Mchr15

45007620

+
In-frameENST00000540797ENST00000558401USP3chr15

63797029

+B2Mchr15

45007620

+
In-frameENST00000540797ENST00000559916USP3chr15

63797029

+B2Mchr15

45007620

+
intron-3CDSENST00000558218ENST00000544417USP3chr15

63797029

+B2Mchr15

45007620

+
intron-3CDSENST00000558218ENST00000558401USP3chr15

63797029

+B2Mchr15

45007620

+
intron-3CDSENST00000558218ENST00000559916USP3chr15

63797029

+B2Mchr15

45007620

+
intron-3CDSENST00000558285ENST00000544417USP3chr15

63797029

+B2Mchr15

45007620

+
intron-3CDSENST00000558285ENST00000558401USP3chr15

63797029

+B2Mchr15

45007620

+
intron-3CDSENST00000558285ENST00000559916USP3chr15

63797029

+B2Mchr15

45007620

+
intron-3CDSENST00000559711ENST00000544417USP3chr15

63797029

+B2Mchr15

45007620

+
intron-3CDSENST00000559711ENST00000558401USP3chr15

63797029

+B2Mchr15

45007620

+
intron-3CDSENST00000559711ENST00000559916USP3chr15

63797029

+B2Mchr15

45007620

+
intron-intronENST00000558218ENST00000559220USP3chr15

63797029

+B2Mchr15

45007620

+
intron-intronENST00000558285ENST00000559220USP3chr15

63797029

+B2Mchr15

45007620

+
intron-intronENST00000559711ENST00000559220USP3chr15

63797029

+B2Mchr15

45007620

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540797USP3chr1563797029+ENST00000558401B2Mchr1545007620+18142364528174
ENST00000540797USP3chr1563797029+ENST00000559916B2Mchr1545007620+12162364528174
ENST00000380324USP3chr1563797029+ENST00000558401B2Mchr1545007620+1798220129512127
ENST00000380324USP3chr1563797029+ENST00000559916B2Mchr1545007620+1200220129512127
ENST00000536001USP3chr1563797029+ENST00000558401B2Mchr1545007620+175317584467127
ENST00000536001USP3chr1563797029+ENST00000559916B2Mchr1545007620+115517584467127

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540797ENST00000558401USP3chr1563797029+B2Mchr1545007620+0.0078610530.9921389
ENST00000540797ENST00000559916USP3chr1563797029+B2Mchr1545007620+0.0142632580.9857368
ENST00000380324ENST00000558401USP3chr1563797029+B2Mchr1545007620+0.0118663980.9881336
ENST00000380324ENST00000559916USP3chr1563797029+B2Mchr1545007620+0.0116482680.98835176
ENST00000536001ENST00000558401USP3chr1563797029+B2Mchr1545007620+0.0061322570.9938678
ENST00000536001ENST00000559916USP3chr1563797029+B2Mchr1545007620+0.0089037990.99109626

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Fusion Genomic Features for USP3-B2M


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
USP3chr1563797029+B2Mchr1545007620+0.0008959580.99910396
USP3chr1563797029+B2Mchr1545007620+0.0008959580.99910396

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for USP3-B2M


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:63797029/chr15:45007620)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.B2M

P61769

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneB2Mchr15:63797029chr15:45007620ENST000005584010425_11322498.0DomainNote=Ig-like C1-type
TgeneB2Mchr15:63797029chr15:45007620ENST000005599160325_11322120.0DomainNote=Ig-like C1-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP3chr15:63797029chr15:45007620ENST00000380324+115159_51130521.0DomainNote=USP
HgeneUSP3chr15:63797029chr15:45007620ENST00000540797+114159_51130477.0DomainNote=USP
HgeneUSP3chr15:63797029chr15:45007620ENST00000380324+11527_10430521.0Zinc fingerUBP-type
HgeneUSP3chr15:63797029chr15:45007620ENST00000540797+11427_10430477.0Zinc fingerUBP-type


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Fusion Gene Sequence for USP3-B2M


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97460_97460_1_USP3-B2M_USP3_chr15_63797029_ENST00000380324_B2M_chr15_45007620_ENST00000558401_length(transcript)=1798nt_BP=220nt
CTCGAGACGCAGCCGCCGTCGGCCGAGCGCCCGGCTAGAAGCGACACCAGACGGAGCCTCCGGAGTTCCTCCGCCCCCACCTCGCCGGGT
CCTGGAGCCGCAGTCCTCCCAGCTGCCCTCCTCGTGGCCATGGAGTGTCCACACCTGAGCTCCAGCGTCTGCATTGCTCCGGACTCAGCC
AAGTTCCCCAACGGCTCCCCGTCGTCCTGGTGCTGCAGCGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAG
TCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTG
GAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCC
TGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATGGAGGTTTGAAGATGCC
GCATTTGGATTGGATGAATTCCAAATTCTGCTTGCTTGCTTTTTAATATTGATATGCTTATACACTTACACTTTATGCACAAAATGTAGG
GTTATAATAATGTTAACATGGACATGATCTTCTTTATAATTCTACTTTGAGTGCTGTCTCCATGTTTGATGTATCTGAGCAGGTTGCTCC
ACAGGTAGCTCTAGGAGGGCTGGCAACTTAGAGGTGGGGAGCAGAGAATTCTCTTATCCAACATCAACATCTTGGTCAGATTTGAACTCT
TCAATCTCTTGCACTCAAAGCTTGTTAAGATAGTTAAGCGTGCATAAGTTAACTTCCAATTTACATACTCTGCTTAGAATTTGGGGGAAA
ATTTAGAAATATAATTGACAGGATTATTGGAAATTTGTTATAATGAATGAAACATTTTGTCATATAAGATTCATATTTACTTCTTATACA
TTTGATAAAGTAAGGCATGGTTGTGGTTAATCTGGTTTATTTTTGTTCCACAAGTTAAATAAATCATAAAACTTGATGTGTTATCTCTTA
TATCTCACTCCCACTATTACCCCTTTATTTTCAAACAGGGAAACAGTCTTCAAGTTCCACTTGGTAAAAAATGTGAACCCCTTGTATATA
GAGTTTGGCTCACAGTGTAAAGGGCCTCAGTGATTCACATTTTCCAGATTAGGAATCTGATGCTCAAAGAAGTTAAATGGCATAGTTGGG
GTGACACAGCTGTCTAGTGGGAGGCCAGCCTTCTATATTTTAGCCAGCGTTCTTTCCTGCGGGCCAGGTCATGAGGAGTATGCAGACTCT
AAGAGGGAGCAAAAGTATCTGAAGGATTTAATATTTTAGCAAGGAATAGATATACAATCATCCCTTGGTCTCCCTGGGGGATTGGTTTCA
GGACCCCTTCTTGGACACCAAATCTATGGATATTTAAGTCCCTTCTATAAAATGGTATAGTATTTGCATATAACCTATCCACATCCTCCT
GTATACTTTAAATCATTTCTAGATTACTTGTAATACCTAATACAATGTAAATGCTATGCAAATAGTTGTTATTGTTTAAGGAATAATGAC
AAGAAAAAAAAGTCTGTACATGCTCAGTAAAGACACAACCATCCCTTTTTTTCCCCAGTGTTTTTGATCCATGGTTTGCTGAATCCACAG

>97460_97460_1_USP3-B2M_USP3_chr15_63797029_ENST00000380324_B2M_chr15_45007620_ENST00000558401_length(amino acids)=127AA_BP=29
MECPHLSSSVCIAPDSAKFPNGSPSSWCCSGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSF

--------------------------------------------------------------
>97460_97460_2_USP3-B2M_USP3_chr15_63797029_ENST00000380324_B2M_chr15_45007620_ENST00000559916_length(transcript)=1200nt_BP=220nt
CTCGAGACGCAGCCGCCGTCGGCCGAGCGCCCGGCTAGAAGCGACACCAGACGGAGCCTCCGGAGTTCCTCCGCCCCCACCTCGCCGGGT
CCTGGAGCCGCAGTCCTCCCAGCTGCCCTCCTCGTGGCCATGGAGTGTCCACACCTGAGCTCCAGCGTCTGCATTGCTCCGGACTCAGCC
AAGTTCCCCAACGGCTCCCCGTCGTCCTGGTGCTGCAGCGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAG
TCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTG
GAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCC
TGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATGGAGGTAAGTTTTTGAC
CTTGAGAAAATGTTTTTGTTTCACTGTCCTGAGGACTATTTATAGACAGCTCTAACATGATAACCCTCACTATGTGGAGAACATTGACAG
AGTAACATTTTAGCAGGGAAAGAAGAATCCTACAGGGTCATGTTCCCTTCTCCTGTGGAGTGGCATGAAGAAGGTGTATGGCCCCAGGTA
TGGCCATATTACTGACCCTCTACAGAGAGGGCAAAGGAACTGCCAGTATGGTATTGCAGGATAAAGGCAGGTGGTTACCCACATTACCTG
CAAGGCTTTGATCTTTCTTCTGCCATTTCCACATTGGACATCTCTGCTGAGGAGAGAAAATGAACCACTCTTTTCCTTTGTATAATGTTG
TTTTATTCTTCAGACAGAAGAGAGGAGTTATACAGCTCTGCAGACATCCCATTCCTGTATGGGGACTGTGTTTGCCTCTTAGAGGTTCCC
AGGCCACTAGAGGAGATAAAGGGAAACAGATTGTTATAACTTGATATAATGATACTATAATAGATGTAACTACAAGGAGCTCCAGAAGCA
AGAGAGAGGGAGGAACTTGGACTTCTCTGCATCTTTAGTTGGAGTCCAAAGGCTTTTCAATGAAATTCTACTGCCCAGGGTACATTGATG

>97460_97460_2_USP3-B2M_USP3_chr15_63797029_ENST00000380324_B2M_chr15_45007620_ENST00000559916_length(amino acids)=127AA_BP=29
MECPHLSSSVCIAPDSAKFPNGSPSSWCCSGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSF

--------------------------------------------------------------
>97460_97460_3_USP3-B2M_USP3_chr15_63797029_ENST00000536001_B2M_chr15_45007620_ENST00000558401_length(transcript)=1753nt_BP=175nt
ACCAGACGGAGCCTCCGGAGTTCCTCCGCCCCCACCTCGCCGGGTCCTGGAGCCGCAGTCCTCCCAGCTGCCCTCCTCGTGGCCATGGAG
TGTCCACACCTGAGCTCCAGCGTCTGCATTGCTCCGGACTCAGCCAAGTTCCCCAACGGCTCCCCGTCGTCCTGGTGCTGCAGCGGTACT
CCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGAC
ATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTC
TTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAG
TGGGATCGAGACATGTAAGCAGCATCATGGAGGTTTGAAGATGCCGCATTTGGATTGGATGAATTCCAAATTCTGCTTGCTTGCTTTTTA
ATATTGATATGCTTATACACTTACACTTTATGCACAAAATGTAGGGTTATAATAATGTTAACATGGACATGATCTTCTTTATAATTCTAC
TTTGAGTGCTGTCTCCATGTTTGATGTATCTGAGCAGGTTGCTCCACAGGTAGCTCTAGGAGGGCTGGCAACTTAGAGGTGGGGAGCAGA
GAATTCTCTTATCCAACATCAACATCTTGGTCAGATTTGAACTCTTCAATCTCTTGCACTCAAAGCTTGTTAAGATAGTTAAGCGTGCAT
AAGTTAACTTCCAATTTACATACTCTGCTTAGAATTTGGGGGAAAATTTAGAAATATAATTGACAGGATTATTGGAAATTTGTTATAATG
AATGAAACATTTTGTCATATAAGATTCATATTTACTTCTTATACATTTGATAAAGTAAGGCATGGTTGTGGTTAATCTGGTTTATTTTTG
TTCCACAAGTTAAATAAATCATAAAACTTGATGTGTTATCTCTTATATCTCACTCCCACTATTACCCCTTTATTTTCAAACAGGGAAACA
GTCTTCAAGTTCCACTTGGTAAAAAATGTGAACCCCTTGTATATAGAGTTTGGCTCACAGTGTAAAGGGCCTCAGTGATTCACATTTTCC
AGATTAGGAATCTGATGCTCAAAGAAGTTAAATGGCATAGTTGGGGTGACACAGCTGTCTAGTGGGAGGCCAGCCTTCTATATTTTAGCC
AGCGTTCTTTCCTGCGGGCCAGGTCATGAGGAGTATGCAGACTCTAAGAGGGAGCAAAAGTATCTGAAGGATTTAATATTTTAGCAAGGA
ATAGATATACAATCATCCCTTGGTCTCCCTGGGGGATTGGTTTCAGGACCCCTTCTTGGACACCAAATCTATGGATATTTAAGTCCCTTC
TATAAAATGGTATAGTATTTGCATATAACCTATCCACATCCTCCTGTATACTTTAAATCATTTCTAGATTACTTGTAATACCTAATACAA
TGTAAATGCTATGCAAATAGTTGTTATTGTTTAAGGAATAATGACAAGAAAAAAAAGTCTGTACATGCTCAGTAAAGACACAACCATCCC
TTTTTTTCCCCAGTGTTTTTGATCCATGGTTTGCTGAATCCACAGATGTGGAGCCCCTGGATACGGAAGGCCCGCTGTACTTTGAATGAC

>97460_97460_3_USP3-B2M_USP3_chr15_63797029_ENST00000536001_B2M_chr15_45007620_ENST00000558401_length(amino acids)=127AA_BP=29
MECPHLSSSVCIAPDSAKFPNGSPSSWCCSGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSF

--------------------------------------------------------------
>97460_97460_4_USP3-B2M_USP3_chr15_63797029_ENST00000536001_B2M_chr15_45007620_ENST00000559916_length(transcript)=1155nt_BP=175nt
ACCAGACGGAGCCTCCGGAGTTCCTCCGCCCCCACCTCGCCGGGTCCTGGAGCCGCAGTCCTCCCAGCTGCCCTCCTCGTGGCCATGGAG
TGTCCACACCTGAGCTCCAGCGTCTGCATTGCTCCGGACTCAGCCAAGTTCCCCAACGGCTCCCCGTCGTCCTGGTGCTGCAGCGGTACT
CCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGAC
ATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTC
TTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAG
TGGGATCGAGACATGTAAGCAGCATCATGGAGGTAAGTTTTTGACCTTGAGAAAATGTTTTTGTTTCACTGTCCTGAGGACTATTTATAG
ACAGCTCTAACATGATAACCCTCACTATGTGGAGAACATTGACAGAGTAACATTTTAGCAGGGAAAGAAGAATCCTACAGGGTCATGTTC
CCTTCTCCTGTGGAGTGGCATGAAGAAGGTGTATGGCCCCAGGTATGGCCATATTACTGACCCTCTACAGAGAGGGCAAAGGAACTGCCA
GTATGGTATTGCAGGATAAAGGCAGGTGGTTACCCACATTACCTGCAAGGCTTTGATCTTTCTTCTGCCATTTCCACATTGGACATCTCT
GCTGAGGAGAGAAAATGAACCACTCTTTTCCTTTGTATAATGTTGTTTTATTCTTCAGACAGAAGAGAGGAGTTATACAGCTCTGCAGAC
ATCCCATTCCTGTATGGGGACTGTGTTTGCCTCTTAGAGGTTCCCAGGCCACTAGAGGAGATAAAGGGAAACAGATTGTTATAACTTGAT
ATAATGATACTATAATAGATGTAACTACAAGGAGCTCCAGAAGCAAGAGAGAGGGAGGAACTTGGACTTCTCTGCATCTTTAGTTGGAGT

>97460_97460_4_USP3-B2M_USP3_chr15_63797029_ENST00000536001_B2M_chr15_45007620_ENST00000559916_length(amino acids)=127AA_BP=29
MECPHLSSSVCIAPDSAKFPNGSPSSWCCSGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSF

--------------------------------------------------------------
>97460_97460_5_USP3-B2M_USP3_chr15_63797029_ENST00000540797_B2M_chr15_45007620_ENST00000558401_length(transcript)=1814nt_BP=236nt
TTCTTTGACGCAAGGGCTCGAGACGCAGCCGCCGTCGGCCGAGCGCCCGGCTAGAAGCGACACCAGACGGAGCCTCCGGAGTTCCTCCGC
CCCCACCTCGCCGGGTCCTGGAGCCGCAGTCCTCCCAGCTGCCCTCCTCGTGGCCATGGAGTGTCCACACCTGAGCTCCAGCGTCTGCAT
TGCTCCGGACTCAGCCAAGTTCCCCAACGGCTCCCCGTCGTCCTGGTGCTGCAGCGGTACTCCAAAGATTCAGGTTTACTCACGTCATCC
AGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGA
GAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGA
AAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATG
GAGGTTTGAAGATGCCGCATTTGGATTGGATGAATTCCAAATTCTGCTTGCTTGCTTTTTAATATTGATATGCTTATACACTTACACTTT
ATGCACAAAATGTAGGGTTATAATAATGTTAACATGGACATGATCTTCTTTATAATTCTACTTTGAGTGCTGTCTCCATGTTTGATGTAT
CTGAGCAGGTTGCTCCACAGGTAGCTCTAGGAGGGCTGGCAACTTAGAGGTGGGGAGCAGAGAATTCTCTTATCCAACATCAACATCTTG
GTCAGATTTGAACTCTTCAATCTCTTGCACTCAAAGCTTGTTAAGATAGTTAAGCGTGCATAAGTTAACTTCCAATTTACATACTCTGCT
TAGAATTTGGGGGAAAATTTAGAAATATAATTGACAGGATTATTGGAAATTTGTTATAATGAATGAAACATTTTGTCATATAAGATTCAT
ATTTACTTCTTATACATTTGATAAAGTAAGGCATGGTTGTGGTTAATCTGGTTTATTTTTGTTCCACAAGTTAAATAAATCATAAAACTT
GATGTGTTATCTCTTATATCTCACTCCCACTATTACCCCTTTATTTTCAAACAGGGAAACAGTCTTCAAGTTCCACTTGGTAAAAAATGT
GAACCCCTTGTATATAGAGTTTGGCTCACAGTGTAAAGGGCCTCAGTGATTCACATTTTCCAGATTAGGAATCTGATGCTCAAAGAAGTT
AAATGGCATAGTTGGGGTGACACAGCTGTCTAGTGGGAGGCCAGCCTTCTATATTTTAGCCAGCGTTCTTTCCTGCGGGCCAGGTCATGA
GGAGTATGCAGACTCTAAGAGGGAGCAAAAGTATCTGAAGGATTTAATATTTTAGCAAGGAATAGATATACAATCATCCCTTGGTCTCCC
TGGGGGATTGGTTTCAGGACCCCTTCTTGGACACCAAATCTATGGATATTTAAGTCCCTTCTATAAAATGGTATAGTATTTGCATATAAC
CTATCCACATCCTCCTGTATACTTTAAATCATTTCTAGATTACTTGTAATACCTAATACAATGTAAATGCTATGCAAATAGTTGTTATTG
TTTAAGGAATAATGACAAGAAAAAAAAGTCTGTACATGCTCAGTAAAGACACAACCATCCCTTTTTTTCCCCAGTGTTTTTGATCCATGG
TTTGCTGAATCCACAGATGTGGAGCCCCTGGATACGGAAGGCCCGCTGTACTTTGAATGACAAATAACAGATTTAAAATTTTCAAGGCAT

>97460_97460_5_USP3-B2M_USP3_chr15_63797029_ENST00000540797_B2M_chr15_45007620_ENST00000558401_length(amino acids)=174AA_BP=76
MTQGLETQPPSAERPARSDTRRSLRSSSAPTSPGPGAAVLPAALLVAMECPHLSSSVCIAPDSAKFPNGSPSSWCCSGTPKIQVYSRHPA

--------------------------------------------------------------
>97460_97460_6_USP3-B2M_USP3_chr15_63797029_ENST00000540797_B2M_chr15_45007620_ENST00000559916_length(transcript)=1216nt_BP=236nt
TTCTTTGACGCAAGGGCTCGAGACGCAGCCGCCGTCGGCCGAGCGCCCGGCTAGAAGCGACACCAGACGGAGCCTCCGGAGTTCCTCCGC
CCCCACCTCGCCGGGTCCTGGAGCCGCAGTCCTCCCAGCTGCCCTCCTCGTGGCCATGGAGTGTCCACACCTGAGCTCCAGCGTCTGCAT
TGCTCCGGACTCAGCCAAGTTCCCCAACGGCTCCCCGTCGTCCTGGTGCTGCAGCGGTACTCCAAAGATTCAGGTTTACTCACGTCATCC
AGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGA
GAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGA
AAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATG
GAGGTAAGTTTTTGACCTTGAGAAAATGTTTTTGTTTCACTGTCCTGAGGACTATTTATAGACAGCTCTAACATGATAACCCTCACTATG
TGGAGAACATTGACAGAGTAACATTTTAGCAGGGAAAGAAGAATCCTACAGGGTCATGTTCCCTTCTCCTGTGGAGTGGCATGAAGAAGG
TGTATGGCCCCAGGTATGGCCATATTACTGACCCTCTACAGAGAGGGCAAAGGAACTGCCAGTATGGTATTGCAGGATAAAGGCAGGTGG
TTACCCACATTACCTGCAAGGCTTTGATCTTTCTTCTGCCATTTCCACATTGGACATCTCTGCTGAGGAGAGAAAATGAACCACTCTTTT
CCTTTGTATAATGTTGTTTTATTCTTCAGACAGAAGAGAGGAGTTATACAGCTCTGCAGACATCCCATTCCTGTATGGGGACTGTGTTTG
CCTCTTAGAGGTTCCCAGGCCACTAGAGGAGATAAAGGGAAACAGATTGTTATAACTTGATATAATGATACTATAATAGATGTAACTACA
AGGAGCTCCAGAAGCAAGAGAGAGGGAGGAACTTGGACTTCTCTGCATCTTTAGTTGGAGTCCAAAGGCTTTTCAATGAAATTCTACTGC

>97460_97460_6_USP3-B2M_USP3_chr15_63797029_ENST00000540797_B2M_chr15_45007620_ENST00000559916_length(amino acids)=174AA_BP=76
MTQGLETQPPSAERPARSDTRRSLRSSSAPTSPGPGAAVLPAALLVAMECPHLSSSVCIAPDSAKFPNGSPSSWCCSGTPKIQVYSRHPA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USP3-B2M


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP3-B2M


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP3-B2M


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource