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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP3-HERC1 (FusionGDB2 ID:97461)

Fusion Gene Summary for USP3-HERC1

check button Fusion gene summary
Fusion gene informationFusion gene name: USP3-HERC1
Fusion gene ID: 97461
HgeneTgene
Gene symbol

USP3

HERC1

Gene ID

9960

8925

Gene nameubiquitin specific peptidase 3HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
SynonymsSIH003|UBPMDFPMR|p532|p619
Cytomap

15q22.31

15q22.31

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 3deubiquitinating enzyme 3ubiquitin thioesterase 3ubiquitin thiolesterase 3ubiquitin-specific-processing protease 3probable E3 ubiquitin-protein ligase HERC1HECT domain and RCC1-like domain-containing protein 1HECT-type E3 ubiquitin transferase HERC1guanine nucleotide exchange factor p532hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC
Modification date2020031320200313
UniProtAcc.

Q15751

Ensembl transtripts involved in fusion geneENST00000268049, ENST00000539772, 
ENST00000380324, ENST00000536001, 
ENST00000540797, ENST00000558218, 
ENST00000558285, ENST00000559711, 
ENST00000443617, 
Fusion gene scores* DoF score11 X 8 X 6=52811 X 12 X 6=792
# samples 1312
** MAII scorelog2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/792*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP3 [Title/Abstract] AND HERC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP3(63797029)-HERC1(63955403), # samples:2
HERC1(63961737)-USP3(63821213), # samples:1
HERC1(63915014)-USP3(63845914), # samples:1
Anticipated loss of major functional domain due to fusion event.HERC1-USP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HERC1-USP3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
HERC1-USP3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP3

GO:0016578

histone deubiquitination

17980597

HgeneUSP3

GO:0031647

regulation of protein stability

17980597


check buttonFusion gene breakpoints across USP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HERC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-8139-01AUSP3chr15

63797029

-HERC1chr15

63955403

-
ChimerDB4LUSCTCGA-77-8139-01AUSP3chr15

63797029

+HERC1chr15

63955403

-


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Fusion Gene ORF analysis for USP3-HERC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000268049ENST00000443617USP3chr15

63797029

+HERC1chr15

63955403

-
5UTR-3CDSENST00000539772ENST00000443617USP3chr15

63797029

+HERC1chr15

63955403

-
In-frameENST00000380324ENST00000443617USP3chr15

63797029

+HERC1chr15

63955403

-
In-frameENST00000536001ENST00000443617USP3chr15

63797029

+HERC1chr15

63955403

-
In-frameENST00000540797ENST00000443617USP3chr15

63797029

+HERC1chr15

63955403

-
intron-3CDSENST00000558218ENST00000443617USP3chr15

63797029

+HERC1chr15

63955403

-
intron-3CDSENST00000558285ENST00000443617USP3chr15

63797029

+HERC1chr15

63955403

-
intron-3CDSENST00000559711ENST00000443617USP3chr15

63797029

+HERC1chr15

63955403

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540797USP3chr1563797029+ENST00000443617HERC1chr1563955403-6605236461412045
ENST00000380324USP3chr1563797029+ENST00000443617HERC1chr1563955403-658922012961251998
ENST00000536001USP3chr1563797029+ENST00000443617HERC1chr1563955403-65441758460801998

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540797ENST00000443617USP3chr1563797029+HERC1chr1563955403-0.0015652530.9984347
ENST00000380324ENST00000443617USP3chr1563797029+HERC1chr1563955403-0.0015502420.9984497
ENST00000536001ENST00000443617USP3chr1563797029+HERC1chr1563955403-0.0014337870.9985662

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Fusion Genomic Features for USP3-HERC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP3-HERC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:63797029/chr15:63955403)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HERC1

Q15751

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742784501_484828934862.0DomainHECT
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742783426_346528934862.0RepeatNote=WD 1
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742783484_352228934862.0RepeatNote=WD 2
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742783524_357228934862.0RepeatNote=WD 3
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742783580_361928934862.0RepeatNote=WD 4
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742783624_366328934862.0RepeatNote=WD 5
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742783667_371328934862.0RepeatNote=WD 6
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742783745_378428934862.0RepeatNote=WD 7
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742783996_404428934862.0RepeatNote=RCC1 8
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742784046_409928934862.0RepeatNote=RCC1 9
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742784101_415128934862.0RepeatNote=RCC1 10
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742784153_420328934862.0RepeatNote=RCC1 11
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742784205_425628934862.0RepeatNote=RCC1 12
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742784258_430828934862.0RepeatNote=RCC1 13
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742784310_436028934862.0RepeatNote=RCC1 14

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP3chr15:63797029chr15:63955403ENST00000380324+115159_51130521.0DomainNote=USP
HgeneUSP3chr15:63797029chr15:63955403ENST00000540797+114159_51130477.0DomainNote=USP
HgeneUSP3chr15:63797029chr15:63955403ENST00000380324+11527_10430521.0Zinc fingerUBP-type
HgeneUSP3chr15:63797029chr15:63955403ENST00000540797+11427_10430477.0Zinc fingerUBP-type
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742781349_137828934862.0Compositional biasNote=Glu-rich
TgeneHERC1chr15:63797029chr15:63955403ENST0000044361742782002_219328934862.0DomainB30.2/SPRY
TgeneHERC1chr15:63797029chr15:63955403ENST000004436174278371_42028934862.0RepeatNote=RCC1 1
TgeneHERC1chr15:63797029chr15:63955403ENST000004436174278421_47528934862.0RepeatNote=RCC1 2
TgeneHERC1chr15:63797029chr15:63955403ENST000004436174278476_52828934862.0RepeatNote=RCC1 3
TgeneHERC1chr15:63797029chr15:63955403ENST000004436174278529_57828934862.0RepeatNote=RCC1 4
TgeneHERC1chr15:63797029chr15:63955403ENST000004436174278580_63128934862.0RepeatNote=RCC1 5
TgeneHERC1chr15:63797029chr15:63955403ENST000004436174278633_68228934862.0RepeatNote=RCC1 6
TgeneHERC1chr15:63797029chr15:63955403ENST000004436174278683_73528934862.0RepeatNote=RCC1 7


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Fusion Gene Sequence for USP3-HERC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97461_97461_1_USP3-HERC1_USP3_chr15_63797029_ENST00000380324_HERC1_chr15_63955403_ENST00000443617_length(transcript)=6589nt_BP=220nt
CTCGAGACGCAGCCGCCGTCGGCCGAGCGCCCGGCTAGAAGCGACACCAGACGGAGCCTCCGGAGTTCCTCCGCCCCCACCTCGCCGGGT
CCTGGAGCCGCAGTCCTCCCAGCTGCCCTCCTCGTGGCCATGGAGTGTCCACACCTGAGCTCCAGCGTCTGCATTGCTCCGGACTCAGCC
AAGTTCCCCAACGGCTCCCCGTCGTCCTGGTGCTGCAGCGCGGGATTATACCGCTCTGTGCAGGCCCACAGGAATCAAAGTCGGAGAGAA
GGAATATCTTTGCAGCAAGACCCAGGGGCGTTGTATGACTTTAATTTAGATGAGGAATTGGAAATTGATCTTGATGATGAGGCGATGGAA
GCTATGTTTGGACAAGACCTGACCAGTGACAATGATATTCTGGGAATGTGGATCCCAGAGGTACTGGATTGGCCTACCTGGCATGTTTGT
GAGTCTGAAGACAGGGAAGAAGTGGTGGTGTGTGAACTGTGTGAATGCAGCGTCGTCAGCTTCAATCAGCACATGAAGAGAAACCATCCA
GGCTGTGGGCGCAGTGCAAACCGCCAGGGCTATCGCAGCAATGGTTCCTATGTGGATGGCTGGTTTGGCGGTGAATGTGGGAGTGGAAAT
CCGTACTACCTGTTATGTGGCACCTGCAGGGAGAAGTACTTAGCCATGAAGACCAAATCTAAGTCAACAAGTTCTGAAAGGTACAAGGGA
CAAGCTCCAGATCTAATTGGCAAGCAAGACAGTGTGTATGAAGAAGACTGGGACATGTTGGATGTTGATGAAGATGAAAAGCTAACTGGT
GAAGAAGAATTTGAATTACTTGCTGGACCGCTTGGTTTAAATGACCGGCGCATTGTACCAGAACCAGTTCAGTTCCCTGACAGCGATCCA
CTGGGAGCATCAGTAGCAATGGTCACAGCCACCAACAGTATGGAAGAGACTCTGATGCAAATAGGTTGCCATGGCTCCGTAGAAAAGAGC
TCCTCTGGGAGAATAACGTTAGGAGAGCAGGCAGCTGCCCTAGCAAACCCTCATGACCGTGTGGTGGCTTTAAGGAGAGTGACTGCTGCT
GCTCAGGTTCTTCTGGCCAGAACCATGGTCATGAGAGCGCTGTCTCTTCTCTCAGTCAGTGGTTCCAGTTGTAGCCTGGCTGCTGGTCTT
GAGTCTCTGGGGCTAACAGATATCCGAACGCTAGTTCGATTAATGTGCTTGGCAGCAGCAGGGAGAGCTGGCCTCTCCACCAGCCCTTCT
GCCATGGCTAGCACCTCAGAACGATCACGAGGTGGGCATAGCAAGGCTAACAAGCCTATCTCTTGCCTGGCCTATTTGAGCACAGCAGTG
GGATGTCTGGCATCAAATGCTCCTAGTGCTGCCAAACTGCTTGTACAGTTGTGTACACAGAACTTGATTTCTGCTGCAACAGGTGTAAAT
CTAACCACAGTTGATGACTCAATTCAGCGAAAGTTTCTACCCAGCTTTCTCCGAGGAATTGCTGAAGAGAACAAGCTTGTGACCTCCCCA
AACTTTGTTGTAACACAGGCCCTTGTGGCATTGCTAGCAGACAAAGGGGCCAAACTAAGACCTAACTATGATAAGTCAGAAGTTGAAAAG
AAAGGCCCTCTGGAGTTGGCTAATGCCCTGGCAGCCTGCTGCCTCTCCTCCAGGCTGTCCTCACAGCATCGGCAATGGGCAGCTCAGCAA
CTCGTGCGCACTCTTGCTGCACACGACCGTGACAACCAAACTACTCTGCAGACACTTGCTGATATGGGAGGAGATCTTAGAAAATGCTCC
TTTATCAAATTGGAGGCTCATCAGAACAGAGTAATGACATGTGTTTGGTGTAATAAAAAAGGTCTTTTGGCTACAAGTGGCAATGATGGC
ACCATCCGCGTATGGAATGTTACCAAGAAGCAATATTCACTGCAACAGACCTGTGTGTTCAACAGATTGGAAGGGGATGCTGAGGAAAGC
CTGGGATCACCCAGTGATCCAAGTTTCTCACCAGTTTCCTGGAGTATCAGTGGCAAATATCTAGCAGGCGCTTTGGAAAAGATGGTGAAT
ATCTGGCAAGTTAATGGAGGAAAAGGATTAGTAGATATTCAGCCTCATTGGGTATCTGCCCTGGCTTGGCCAGAAGAGGGTCCGGCTACA
GCCTGGTCAGGAGAGTCTCCAGAATTGTTGTTGGTGGGACGGATGGATGGATCTCTGGGACTGATTGAAGTTGTTGATGTGTCCACCATG
CACCGTCGAGAATTGGAGCATTGCTATCGAAAGGATGTGTCTGTTACTTGCATTGCATGGTTCAGTGAAGACAGACCATTTGCAGTGGGA
TATTTTGATGGAAAACTGTTACTGGGAACAAAGGAACCACTTGAGAAAGGAGGCATTGTTCTAATTGATGCACATAAGGATACTCTTATT
AGCATGAAGTGGGACCCTACAGGTCATATTCTTATGACATGTGCCAAAGAAGACAGTGTGAAACTCTGGGGCTCTATTTCGGGATGCTGG
TGCTGTCTACATTCACTCTGCCATCCATCTATTGTAAATGGCATTGCTTGGTGCCGCCTTCCAGGGAAAGGATCCAAGTTGCAGTTACTG
ATGGCTACTGGCTGTCAGAGTGGCTTAGTATGTGTTTGGCGCATTCCTCAAGATACTACACAGACCAATGTGACTAGTGCAGAAGGATGG
TGGGAGCAGGAATCAAATTGCCAGGATGGATATAGGAAATCATCAGGAGCCAAGTGTGTTTATCAGCTGCGGGGACACATCACTCCTGTT
CGGACTGTTGCCTTTAGTTCTGATGGGTTGGCCCTGGTGTCTGGTGGACTAGGTGGGCTCATGAACATTTGGTCTTTAAGGGATGGCTCT
GTCTTGCAAACTGTTGTGATAGGCTCTGGAGCTATTCAGACCACAGTATGGATTCCAGAAGTTGGAGTAGCTGCTTGCTCAAATAGATCA
AAGGATGTTTTGGTCGTGAATTGTACAGCAGAATGGGCAGCTGCCAATCATGTTTTGGCAACCTGTAGGACAGCATTGAAACAGCAGGGT
GTTCTGGGATTGAACATGGCTCCCTGCATGAGAGCATTTTTGGAGCGGCTCCCCATGATGCTTCAGGAGCAGTATGCCTATGAAAAGCCT
CATGTGGTTTGTGGTGACCAACTTGTTCATAGCCCCTATATGCAATGCTTGGCTTCCCTTGCTGTGGGACTTCATCTGGATCAGCTGTTG
TGTAACCCTCCAGTGCCACCACACCACCAGAACTGTCTCCCTGACCCTGCATCCTGGAATCCAAATGAATGGGCCTGGTTAGAATGTTTC
TCAACCACTATAAAAGCTGCCGAAGCCCTGACCAATGGAGCCCAGTTTCCAGAATCTTTTACCGTTCCAGATCTAGAACCTGTTCCAGAG
GATGAACTTGTATTTCTAATGGATAACAGTAAATGGATTAACGGCATGGATGAACAAATTATGTCTTGGGCAACTTCCAGACCTGAGGAC
TGGCACCTGGGAGGTAAATGTGATGTCTACTTATGGGGTGCTGGTAGGCATGGACAGCTGGCAGAAGCTGGAAGAAATGTAATGGTACCT
GCAGCAGCTCCCTCATTCTCACAGGCCCAACAGGTCATTTGTGGTCAGAATTGTACCTTTGTCATCCAGGCCAATGGCACAGTGTTGGCT
TGTGGGGAAGGAAGTTATGGCAGATTAGGACAAGGAAATTCAGATGACCTTCATGTGCTGACAGTTATTTCAGCCTTACAAGGCTTTGTG
GTGACCCAGCTGGTGACTTCCTGTGGTTCTGATGGGCACTCTATGGCCCTAACTGAAAGTGGTGAGGTCTTTAGCTGGGGAGATGGTGAC
TATGGTAAACTTGGCCATGGGAACAGCGACAGGCAGCGGCGGCCCAGGCAGATCGAGGCCTTACAAGGAGAAGAAGTGGTGCAGATGTCT
TGTGGCTTCAAGCACTCAGCAGTGGTCACTTCAGATGGCAAACTGTTCACCTTTGGGAATGGTGACTATGGTCGTCTGGGTCTTGGAAAT
ACCTCTAACAAAAAACTTCCAGAGAGAGTGACTGCACTGGAGGGATATCAGATTGGACAGGTGGCCTGTGGATTAAACCACACTTTGGCA
GTGTCAGCAGATGGTTCCATGGTGTGGGCTTTTGGAGATGGAGACTATGGAAAACTAGGCTTAGGAAATTCCACTGCAAAATCTTCACCT
CAGAAAATTGACGTCCTTTGTGGAATTGGAATAAAAAAGGTTGCTTGTGGAACTCAGTTTTCTGTTGCTTTGACCAAAGATGGTCATGTG
TATACCTTTGGTCAAGATCGCCTGATAGGCTTGCCAGAGGGGCGTGCTCGCAATCACAATCGACCGCAACAAATCCCTGTCCTGGCTGGA
GTAATCATAGAAGATGTGGCAGTTGGAGCTGAACACACACTTGCTTTGGCATCAAATGGAGATGTGTATGCCTGGGGGAGCAATTCAGAA
GGGCAGCTCGGCTTAGGCCATACCAACCATGTTCGAGAACCAACCCTGGTAACAGGTCTGCAAGGGAAAAATGTTCGGCAGATCTCGGCT
GGCCGCTGCCACAGTGCTGCATGGACAGCACCACCTGTCCCACCAAGAGCACCAGGTGTGTCAGTACCTCTGCAGCTGGGCCTGCCTGAC
ACAGTGCCCCCCCAGTATGGGGCGCTGAGAGAAGTCAGCATTCACACGGTGCGGGCCAGGCTCCGGCTGCTCTACCACTTCTCTGACCTC
ATGTACTCATCCTGGAGACTGCTGAACCTTAGCCCCAACAACCAGAACAGCACATCCCATTATAATGCTGGAACTTGGGGCATTGTACAG
GGACAACTTCGGCCTTTGTTAGCCCCAAGAGTCTACACTCTGCCAATGGTGCGCTCCATAGGAAAAACCATGGTTCAAGGCAAAAACTAT
GGACCTCAGATAACTGTAAAGAGGATATCAACCAGAGGACGGAAGTGTAAGCCTATTTTTGTCCAAATAGCGAGACAAGTAGTTAAGCTG
AATGCTTCAGACCTCCGCCTGCCTTCCCGAGCGTGGAAGGTTAAGCTGGTTGGAGAAGGGGCTGATGATGCTGGAGGAGTGTTTGATGAC
ACCATCACAGAGATGTGCCAGGAACTTGAAACTGGTATTGTTGACCTTCTTATACCCTCTCCCAATGCCACCGCAGAAGTGGGTTACAAT
AGGGACAGGTTCCTTTTTAACCCTTCTGCCTGCCTCGATGAACACTTAATGCAGTTTAAGTTTTTAGGAATTTTAATGGGGGTTGCCATT
CGCACAAAGAAGCCTCTGGACCTCCACTTGGCCCCTCTGGTGTGGAAGCAGCTGTGCTGTGTCCCACTCACCCTAGAGGACCTGGAGGAG
GTGGATCTGCTCTACGTGCAGACTCTCAACAGCATTCTTCACATTGAAGACAGTGGGATTACCGAGGAGAGTTTCCATGAGATGATTCCT
CTTGATTCTTTTGTTGGCCAGAGTGCTGATGGCAAAATGGTTCCTATAATCCCTGGTGGAAATAGTATCCCACTCACATTTTCCAACAGG
AAGGAATATGTGGAGAGGGCCATTGAATATCGACTTCATGAGATGGACAGACAGGTGGCTGCAGTCCGAGAAGGGATGTCCTGGATTGTT
CCTGTGCCGCTGCTGTCCCTCCTCACAGCAAAACAACTGGAGCAGATGGTGTGTGGGATGCCCGAGATCTCTGTGGAAGTCTTGAAGAAA
GTGGTGCGGTACCGTGAGGTGGATGAGCAGCATCAGCTGGTGCAGTGGTTCTGGCACACGCTGGAAGAGTTCTCCAATGAGGAGCGGGTG
CTTTTCATGAGGTTTGTGTCAGGAAGATCTCGACTACCAGCCAACACTGCTGACATTTCTCAGAGATTTCAAATCATGAAGGTTGATAGG
CCTTACGACAGTCTGCCTACCTCACAGACCTGCTTCTTCCAGCTGAGGCTGCCCCCGTACTCCAGCCAGCTGGTCATGGCCGAGCGCCTG
CGCTATGCCATCAACAACTGCCGCTCAATCGACATGGACAACTACATGCTCTCGAGAAACGTGGACAACGCCGAGGGCTCCGACACTGAC
TACTGACCGTGCGGGTGCTCTCACCCTCCCTTCTCTCCCTCAATAATGCTCACTTCTGATTTGATGTTGATATACTTTTATGGTAACTAC
ATAGATGTTATAAGAACATAAACCAACATTATAAACAATGGCCACATTTAGTTACTCTAAATGTAACAAAGAAATTAGATGTTTTTATTT
TTCTGTGATTGTACAAAAACAACAAAAACGAAGTGCTCTCAGTCAGGTTTTTCCCTCCATATTTTTGGTCACTTTTGATAAGTTTGCATG
AAACCATTTTGGTGCATTTTTAGTTGGGAATGGTACATTTTTGTAAATCCACCCAGTGAACATGAAATTGTACATTGTGTATAATTGTTC
ATTAGAAAGGACAGTTTTACATGAATATTCATATATTTATTTTGTTTTAATTTGAATTGCCTGTTCAGGGTTCCTTATGCAGAGAAATAA

>97461_97461_1_USP3-HERC1_USP3_chr15_63797029_ENST00000380324_HERC1_chr15_63955403_ENST00000443617_length(amino acids)=1998AA_BP=1171
MECPHLSSSVCIAPDSAKFPNGSPSSWCCSAGLYRSVQAHRNQSRREGISLQQDPGALYDFNLDEELEIDLDDEAMEAMFGQDLTSDNDI
LGMWIPEVLDWPTWHVCESEDREEVVVCELCECSVVSFNQHMKRNHPGCGRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGTCREKY
LAMKTKSKSTSSERYKGQAPDLIGKQDSVYEEDWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDSDPLGASVAMVTATNS
MEETLMQIGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRRVTAAAQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVR
LMCLAAAGRAGLSTSPSAMASTSERSRGGHSKANKPISCLAYLSTAVGCLASNAPSAAKLLVQLCTQNLISAATGVNLTTVDDSIQRKFL
PSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNYDKSEVEKKGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQ
TTLQTLADMGGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQYSLQQTCVFNRLEGDAEESLGSPSDPSFSPVS
WSISGKYLAGALEKMVNIWQVNGGKGLVDIQPHWVSALAWPEEGPATAWSGESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKDV
SVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKWDPTGHILMTCAKEDSVKLWGSISGCWCCLHSLCHPSIVN
GIAWCRLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGWWEQESNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALV
SGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSKDVLVVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAF
LERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNG
AQFPESFTVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVI
CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQR
RPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGD
GDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHT
LALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDTVPPQYGALREVS
IHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRG
RKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLD
EHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKM
VPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQL
VQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMD

--------------------------------------------------------------
>97461_97461_2_USP3-HERC1_USP3_chr15_63797029_ENST00000536001_HERC1_chr15_63955403_ENST00000443617_length(transcript)=6544nt_BP=175nt
ACCAGACGGAGCCTCCGGAGTTCCTCCGCCCCCACCTCGCCGGGTCCTGGAGCCGCAGTCCTCCCAGCTGCCCTCCTCGTGGCCATGGAG
TGTCCACACCTGAGCTCCAGCGTCTGCATTGCTCCGGACTCAGCCAAGTTCCCCAACGGCTCCCCGTCGTCCTGGTGCTGCAGCGCGGGA
TTATACCGCTCTGTGCAGGCCCACAGGAATCAAAGTCGGAGAGAAGGAATATCTTTGCAGCAAGACCCAGGGGCGTTGTATGACTTTAAT
TTAGATGAGGAATTGGAAATTGATCTTGATGATGAGGCGATGGAAGCTATGTTTGGACAAGACCTGACCAGTGACAATGATATTCTGGGA
ATGTGGATCCCAGAGGTACTGGATTGGCCTACCTGGCATGTTTGTGAGTCTGAAGACAGGGAAGAAGTGGTGGTGTGTGAACTGTGTGAA
TGCAGCGTCGTCAGCTTCAATCAGCACATGAAGAGAAACCATCCAGGCTGTGGGCGCAGTGCAAACCGCCAGGGCTATCGCAGCAATGGT
TCCTATGTGGATGGCTGGTTTGGCGGTGAATGTGGGAGTGGAAATCCGTACTACCTGTTATGTGGCACCTGCAGGGAGAAGTACTTAGCC
ATGAAGACCAAATCTAAGTCAACAAGTTCTGAAAGGTACAAGGGACAAGCTCCAGATCTAATTGGCAAGCAAGACAGTGTGTATGAAGAA
GACTGGGACATGTTGGATGTTGATGAAGATGAAAAGCTAACTGGTGAAGAAGAATTTGAATTACTTGCTGGACCGCTTGGTTTAAATGAC
CGGCGCATTGTACCAGAACCAGTTCAGTTCCCTGACAGCGATCCACTGGGAGCATCAGTAGCAATGGTCACAGCCACCAACAGTATGGAA
GAGACTCTGATGCAAATAGGTTGCCATGGCTCCGTAGAAAAGAGCTCCTCTGGGAGAATAACGTTAGGAGAGCAGGCAGCTGCCCTAGCA
AACCCTCATGACCGTGTGGTGGCTTTAAGGAGAGTGACTGCTGCTGCTCAGGTTCTTCTGGCCAGAACCATGGTCATGAGAGCGCTGTCT
CTTCTCTCAGTCAGTGGTTCCAGTTGTAGCCTGGCTGCTGGTCTTGAGTCTCTGGGGCTAACAGATATCCGAACGCTAGTTCGATTAATG
TGCTTGGCAGCAGCAGGGAGAGCTGGCCTCTCCACCAGCCCTTCTGCCATGGCTAGCACCTCAGAACGATCACGAGGTGGGCATAGCAAG
GCTAACAAGCCTATCTCTTGCCTGGCCTATTTGAGCACAGCAGTGGGATGTCTGGCATCAAATGCTCCTAGTGCTGCCAAACTGCTTGTA
CAGTTGTGTACACAGAACTTGATTTCTGCTGCAACAGGTGTAAATCTAACCACAGTTGATGACTCAATTCAGCGAAAGTTTCTACCCAGC
TTTCTCCGAGGAATTGCTGAAGAGAACAAGCTTGTGACCTCCCCAAACTTTGTTGTAACACAGGCCCTTGTGGCATTGCTAGCAGACAAA
GGGGCCAAACTAAGACCTAACTATGATAAGTCAGAAGTTGAAAAGAAAGGCCCTCTGGAGTTGGCTAATGCCCTGGCAGCCTGCTGCCTC
TCCTCCAGGCTGTCCTCACAGCATCGGCAATGGGCAGCTCAGCAACTCGTGCGCACTCTTGCTGCACACGACCGTGACAACCAAACTACT
CTGCAGACACTTGCTGATATGGGAGGAGATCTTAGAAAATGCTCCTTTATCAAATTGGAGGCTCATCAGAACAGAGTAATGACATGTGTT
TGGTGTAATAAAAAAGGTCTTTTGGCTACAAGTGGCAATGATGGCACCATCCGCGTATGGAATGTTACCAAGAAGCAATATTCACTGCAA
CAGACCTGTGTGTTCAACAGATTGGAAGGGGATGCTGAGGAAAGCCTGGGATCACCCAGTGATCCAAGTTTCTCACCAGTTTCCTGGAGT
ATCAGTGGCAAATATCTAGCAGGCGCTTTGGAAAAGATGGTGAATATCTGGCAAGTTAATGGAGGAAAAGGATTAGTAGATATTCAGCCT
CATTGGGTATCTGCCCTGGCTTGGCCAGAAGAGGGTCCGGCTACAGCCTGGTCAGGAGAGTCTCCAGAATTGTTGTTGGTGGGACGGATG
GATGGATCTCTGGGACTGATTGAAGTTGTTGATGTGTCCACCATGCACCGTCGAGAATTGGAGCATTGCTATCGAAAGGATGTGTCTGTT
ACTTGCATTGCATGGTTCAGTGAAGACAGACCATTTGCAGTGGGATATTTTGATGGAAAACTGTTACTGGGAACAAAGGAACCACTTGAG
AAAGGAGGCATTGTTCTAATTGATGCACATAAGGATACTCTTATTAGCATGAAGTGGGACCCTACAGGTCATATTCTTATGACATGTGCC
AAAGAAGACAGTGTGAAACTCTGGGGCTCTATTTCGGGATGCTGGTGCTGTCTACATTCACTCTGCCATCCATCTATTGTAAATGGCATT
GCTTGGTGCCGCCTTCCAGGGAAAGGATCCAAGTTGCAGTTACTGATGGCTACTGGCTGTCAGAGTGGCTTAGTATGTGTTTGGCGCATT
CCTCAAGATACTACACAGACCAATGTGACTAGTGCAGAAGGATGGTGGGAGCAGGAATCAAATTGCCAGGATGGATATAGGAAATCATCA
GGAGCCAAGTGTGTTTATCAGCTGCGGGGACACATCACTCCTGTTCGGACTGTTGCCTTTAGTTCTGATGGGTTGGCCCTGGTGTCTGGT
GGACTAGGTGGGCTCATGAACATTTGGTCTTTAAGGGATGGCTCTGTCTTGCAAACTGTTGTGATAGGCTCTGGAGCTATTCAGACCACA
GTATGGATTCCAGAAGTTGGAGTAGCTGCTTGCTCAAATAGATCAAAGGATGTTTTGGTCGTGAATTGTACAGCAGAATGGGCAGCTGCC
AATCATGTTTTGGCAACCTGTAGGACAGCATTGAAACAGCAGGGTGTTCTGGGATTGAACATGGCTCCCTGCATGAGAGCATTTTTGGAG
CGGCTCCCCATGATGCTTCAGGAGCAGTATGCCTATGAAAAGCCTCATGTGGTTTGTGGTGACCAACTTGTTCATAGCCCCTATATGCAA
TGCTTGGCTTCCCTTGCTGTGGGACTTCATCTGGATCAGCTGTTGTGTAACCCTCCAGTGCCACCACACCACCAGAACTGTCTCCCTGAC
CCTGCATCCTGGAATCCAAATGAATGGGCCTGGTTAGAATGTTTCTCAACCACTATAAAAGCTGCCGAAGCCCTGACCAATGGAGCCCAG
TTTCCAGAATCTTTTACCGTTCCAGATCTAGAACCTGTTCCAGAGGATGAACTTGTATTTCTAATGGATAACAGTAAATGGATTAACGGC
ATGGATGAACAAATTATGTCTTGGGCAACTTCCAGACCTGAGGACTGGCACCTGGGAGGTAAATGTGATGTCTACTTATGGGGTGCTGGT
AGGCATGGACAGCTGGCAGAAGCTGGAAGAAATGTAATGGTACCTGCAGCAGCTCCCTCATTCTCACAGGCCCAACAGGTCATTTGTGGT
CAGAATTGTACCTTTGTCATCCAGGCCAATGGCACAGTGTTGGCTTGTGGGGAAGGAAGTTATGGCAGATTAGGACAAGGAAATTCAGAT
GACCTTCATGTGCTGACAGTTATTTCAGCCTTACAAGGCTTTGTGGTGACCCAGCTGGTGACTTCCTGTGGTTCTGATGGGCACTCTATG
GCCCTAACTGAAAGTGGTGAGGTCTTTAGCTGGGGAGATGGTGACTATGGTAAACTTGGCCATGGGAACAGCGACAGGCAGCGGCGGCCC
AGGCAGATCGAGGCCTTACAAGGAGAAGAAGTGGTGCAGATGTCTTGTGGCTTCAAGCACTCAGCAGTGGTCACTTCAGATGGCAAACTG
TTCACCTTTGGGAATGGTGACTATGGTCGTCTGGGTCTTGGAAATACCTCTAACAAAAAACTTCCAGAGAGAGTGACTGCACTGGAGGGA
TATCAGATTGGACAGGTGGCCTGTGGATTAAACCACACTTTGGCAGTGTCAGCAGATGGTTCCATGGTGTGGGCTTTTGGAGATGGAGAC
TATGGAAAACTAGGCTTAGGAAATTCCACTGCAAAATCTTCACCTCAGAAAATTGACGTCCTTTGTGGAATTGGAATAAAAAAGGTTGCT
TGTGGAACTCAGTTTTCTGTTGCTTTGACCAAAGATGGTCATGTGTATACCTTTGGTCAAGATCGCCTGATAGGCTTGCCAGAGGGGCGT
GCTCGCAATCACAATCGACCGCAACAAATCCCTGTCCTGGCTGGAGTAATCATAGAAGATGTGGCAGTTGGAGCTGAACACACACTTGCT
TTGGCATCAAATGGAGATGTGTATGCCTGGGGGAGCAATTCAGAAGGGCAGCTCGGCTTAGGCCATACCAACCATGTTCGAGAACCAACC
CTGGTAACAGGTCTGCAAGGGAAAAATGTTCGGCAGATCTCGGCTGGCCGCTGCCACAGTGCTGCATGGACAGCACCACCTGTCCCACCA
AGAGCACCAGGTGTGTCAGTACCTCTGCAGCTGGGCCTGCCTGACACAGTGCCCCCCCAGTATGGGGCGCTGAGAGAAGTCAGCATTCAC
ACGGTGCGGGCCAGGCTCCGGCTGCTCTACCACTTCTCTGACCTCATGTACTCATCCTGGAGACTGCTGAACCTTAGCCCCAACAACCAG
AACAGCACATCCCATTATAATGCTGGAACTTGGGGCATTGTACAGGGACAACTTCGGCCTTTGTTAGCCCCAAGAGTCTACACTCTGCCA
ATGGTGCGCTCCATAGGAAAAACCATGGTTCAAGGCAAAAACTATGGACCTCAGATAACTGTAAAGAGGATATCAACCAGAGGACGGAAG
TGTAAGCCTATTTTTGTCCAAATAGCGAGACAAGTAGTTAAGCTGAATGCTTCAGACCTCCGCCTGCCTTCCCGAGCGTGGAAGGTTAAG
CTGGTTGGAGAAGGGGCTGATGATGCTGGAGGAGTGTTTGATGACACCATCACAGAGATGTGCCAGGAACTTGAAACTGGTATTGTTGAC
CTTCTTATACCCTCTCCCAATGCCACCGCAGAAGTGGGTTACAATAGGGACAGGTTCCTTTTTAACCCTTCTGCCTGCCTCGATGAACAC
TTAATGCAGTTTAAGTTTTTAGGAATTTTAATGGGGGTTGCCATTCGCACAAAGAAGCCTCTGGACCTCCACTTGGCCCCTCTGGTGTGG
AAGCAGCTGTGCTGTGTCCCACTCACCCTAGAGGACCTGGAGGAGGTGGATCTGCTCTACGTGCAGACTCTCAACAGCATTCTTCACATT
GAAGACAGTGGGATTACCGAGGAGAGTTTCCATGAGATGATTCCTCTTGATTCTTTTGTTGGCCAGAGTGCTGATGGCAAAATGGTTCCT
ATAATCCCTGGTGGAAATAGTATCCCACTCACATTTTCCAACAGGAAGGAATATGTGGAGAGGGCCATTGAATATCGACTTCATGAGATG
GACAGACAGGTGGCTGCAGTCCGAGAAGGGATGTCCTGGATTGTTCCTGTGCCGCTGCTGTCCCTCCTCACAGCAAAACAACTGGAGCAG
ATGGTGTGTGGGATGCCCGAGATCTCTGTGGAAGTCTTGAAGAAAGTGGTGCGGTACCGTGAGGTGGATGAGCAGCATCAGCTGGTGCAG
TGGTTCTGGCACACGCTGGAAGAGTTCTCCAATGAGGAGCGGGTGCTTTTCATGAGGTTTGTGTCAGGAAGATCTCGACTACCAGCCAAC
ACTGCTGACATTTCTCAGAGATTTCAAATCATGAAGGTTGATAGGCCTTACGACAGTCTGCCTACCTCACAGACCTGCTTCTTCCAGCTG
AGGCTGCCCCCGTACTCCAGCCAGCTGGTCATGGCCGAGCGCCTGCGCTATGCCATCAACAACTGCCGCTCAATCGACATGGACAACTAC
ATGCTCTCGAGAAACGTGGACAACGCCGAGGGCTCCGACACTGACTACTGACCGTGCGGGTGCTCTCACCCTCCCTTCTCTCCCTCAATA
ATGCTCACTTCTGATTTGATGTTGATATACTTTTATGGTAACTACATAGATGTTATAAGAACATAAACCAACATTATAAACAATGGCCAC
ATTTAGTTACTCTAAATGTAACAAAGAAATTAGATGTTTTTATTTTTCTGTGATTGTACAAAAACAACAAAAACGAAGTGCTCTCAGTCA
GGTTTTTCCCTCCATATTTTTGGTCACTTTTGATAAGTTTGCATGAAACCATTTTGGTGCATTTTTAGTTGGGAATGGTACATTTTTGTA
AATCCACCCAGTGAACATGAAATTGTACATTGTGTATAATTGTTCATTAGAAAGGACAGTTTTACATGAATATTCATATATTTATTTTGT

>97461_97461_2_USP3-HERC1_USP3_chr15_63797029_ENST00000536001_HERC1_chr15_63955403_ENST00000443617_length(amino acids)=1998AA_BP=1171
MECPHLSSSVCIAPDSAKFPNGSPSSWCCSAGLYRSVQAHRNQSRREGISLQQDPGALYDFNLDEELEIDLDDEAMEAMFGQDLTSDNDI
LGMWIPEVLDWPTWHVCESEDREEVVVCELCECSVVSFNQHMKRNHPGCGRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGTCREKY
LAMKTKSKSTSSERYKGQAPDLIGKQDSVYEEDWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDSDPLGASVAMVTATNS
MEETLMQIGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRRVTAAAQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVR
LMCLAAAGRAGLSTSPSAMASTSERSRGGHSKANKPISCLAYLSTAVGCLASNAPSAAKLLVQLCTQNLISAATGVNLTTVDDSIQRKFL
PSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNYDKSEVEKKGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQ
TTLQTLADMGGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQYSLQQTCVFNRLEGDAEESLGSPSDPSFSPVS
WSISGKYLAGALEKMVNIWQVNGGKGLVDIQPHWVSALAWPEEGPATAWSGESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKDV
SVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKWDPTGHILMTCAKEDSVKLWGSISGCWCCLHSLCHPSIVN
GIAWCRLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGWWEQESNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALV
SGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSKDVLVVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAF
LERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNG
AQFPESFTVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVI
CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQR
RPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGD
GDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHT
LALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDTVPPQYGALREVS
IHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRG
RKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLD
EHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKM
VPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQL
VQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMD

--------------------------------------------------------------
>97461_97461_3_USP3-HERC1_USP3_chr15_63797029_ENST00000540797_HERC1_chr15_63955403_ENST00000443617_length(transcript)=6605nt_BP=236nt
TTCTTTGACGCAAGGGCTCGAGACGCAGCCGCCGTCGGCCGAGCGCCCGGCTAGAAGCGACACCAGACGGAGCCTCCGGAGTTCCTCCGC
CCCCACCTCGCCGGGTCCTGGAGCCGCAGTCCTCCCAGCTGCCCTCCTCGTGGCCATGGAGTGTCCACACCTGAGCTCCAGCGTCTGCAT
TGCTCCGGACTCAGCCAAGTTCCCCAACGGCTCCCCGTCGTCCTGGTGCTGCAGCGCGGGATTATACCGCTCTGTGCAGGCCCACAGGAA
TCAAAGTCGGAGAGAAGGAATATCTTTGCAGCAAGACCCAGGGGCGTTGTATGACTTTAATTTAGATGAGGAATTGGAAATTGATCTTGA
TGATGAGGCGATGGAAGCTATGTTTGGACAAGACCTGACCAGTGACAATGATATTCTGGGAATGTGGATCCCAGAGGTACTGGATTGGCC
TACCTGGCATGTTTGTGAGTCTGAAGACAGGGAAGAAGTGGTGGTGTGTGAACTGTGTGAATGCAGCGTCGTCAGCTTCAATCAGCACAT
GAAGAGAAACCATCCAGGCTGTGGGCGCAGTGCAAACCGCCAGGGCTATCGCAGCAATGGTTCCTATGTGGATGGCTGGTTTGGCGGTGA
ATGTGGGAGTGGAAATCCGTACTACCTGTTATGTGGCACCTGCAGGGAGAAGTACTTAGCCATGAAGACCAAATCTAAGTCAACAAGTTC
TGAAAGGTACAAGGGACAAGCTCCAGATCTAATTGGCAAGCAAGACAGTGTGTATGAAGAAGACTGGGACATGTTGGATGTTGATGAAGA
TGAAAAGCTAACTGGTGAAGAAGAATTTGAATTACTTGCTGGACCGCTTGGTTTAAATGACCGGCGCATTGTACCAGAACCAGTTCAGTT
CCCTGACAGCGATCCACTGGGAGCATCAGTAGCAATGGTCACAGCCACCAACAGTATGGAAGAGACTCTGATGCAAATAGGTTGCCATGG
CTCCGTAGAAAAGAGCTCCTCTGGGAGAATAACGTTAGGAGAGCAGGCAGCTGCCCTAGCAAACCCTCATGACCGTGTGGTGGCTTTAAG
GAGAGTGACTGCTGCTGCTCAGGTTCTTCTGGCCAGAACCATGGTCATGAGAGCGCTGTCTCTTCTCTCAGTCAGTGGTTCCAGTTGTAG
CCTGGCTGCTGGTCTTGAGTCTCTGGGGCTAACAGATATCCGAACGCTAGTTCGATTAATGTGCTTGGCAGCAGCAGGGAGAGCTGGCCT
CTCCACCAGCCCTTCTGCCATGGCTAGCACCTCAGAACGATCACGAGGTGGGCATAGCAAGGCTAACAAGCCTATCTCTTGCCTGGCCTA
TTTGAGCACAGCAGTGGGATGTCTGGCATCAAATGCTCCTAGTGCTGCCAAACTGCTTGTACAGTTGTGTACACAGAACTTGATTTCTGC
TGCAACAGGTGTAAATCTAACCACAGTTGATGACTCAATTCAGCGAAAGTTTCTACCCAGCTTTCTCCGAGGAATTGCTGAAGAGAACAA
GCTTGTGACCTCCCCAAACTTTGTTGTAACACAGGCCCTTGTGGCATTGCTAGCAGACAAAGGGGCCAAACTAAGACCTAACTATGATAA
GTCAGAAGTTGAAAAGAAAGGCCCTCTGGAGTTGGCTAATGCCCTGGCAGCCTGCTGCCTCTCCTCCAGGCTGTCCTCACAGCATCGGCA
ATGGGCAGCTCAGCAACTCGTGCGCACTCTTGCTGCACACGACCGTGACAACCAAACTACTCTGCAGACACTTGCTGATATGGGAGGAGA
TCTTAGAAAATGCTCCTTTATCAAATTGGAGGCTCATCAGAACAGAGTAATGACATGTGTTTGGTGTAATAAAAAAGGTCTTTTGGCTAC
AAGTGGCAATGATGGCACCATCCGCGTATGGAATGTTACCAAGAAGCAATATTCACTGCAACAGACCTGTGTGTTCAACAGATTGGAAGG
GGATGCTGAGGAAAGCCTGGGATCACCCAGTGATCCAAGTTTCTCACCAGTTTCCTGGAGTATCAGTGGCAAATATCTAGCAGGCGCTTT
GGAAAAGATGGTGAATATCTGGCAAGTTAATGGAGGAAAAGGATTAGTAGATATTCAGCCTCATTGGGTATCTGCCCTGGCTTGGCCAGA
AGAGGGTCCGGCTACAGCCTGGTCAGGAGAGTCTCCAGAATTGTTGTTGGTGGGACGGATGGATGGATCTCTGGGACTGATTGAAGTTGT
TGATGTGTCCACCATGCACCGTCGAGAATTGGAGCATTGCTATCGAAAGGATGTGTCTGTTACTTGCATTGCATGGTTCAGTGAAGACAG
ACCATTTGCAGTGGGATATTTTGATGGAAAACTGTTACTGGGAACAAAGGAACCACTTGAGAAAGGAGGCATTGTTCTAATTGATGCACA
TAAGGATACTCTTATTAGCATGAAGTGGGACCCTACAGGTCATATTCTTATGACATGTGCCAAAGAAGACAGTGTGAAACTCTGGGGCTC
TATTTCGGGATGCTGGTGCTGTCTACATTCACTCTGCCATCCATCTATTGTAAATGGCATTGCTTGGTGCCGCCTTCCAGGGAAAGGATC
CAAGTTGCAGTTACTGATGGCTACTGGCTGTCAGAGTGGCTTAGTATGTGTTTGGCGCATTCCTCAAGATACTACACAGACCAATGTGAC
TAGTGCAGAAGGATGGTGGGAGCAGGAATCAAATTGCCAGGATGGATATAGGAAATCATCAGGAGCCAAGTGTGTTTATCAGCTGCGGGG
ACACATCACTCCTGTTCGGACTGTTGCCTTTAGTTCTGATGGGTTGGCCCTGGTGTCTGGTGGACTAGGTGGGCTCATGAACATTTGGTC
TTTAAGGGATGGCTCTGTCTTGCAAACTGTTGTGATAGGCTCTGGAGCTATTCAGACCACAGTATGGATTCCAGAAGTTGGAGTAGCTGC
TTGCTCAAATAGATCAAAGGATGTTTTGGTCGTGAATTGTACAGCAGAATGGGCAGCTGCCAATCATGTTTTGGCAACCTGTAGGACAGC
ATTGAAACAGCAGGGTGTTCTGGGATTGAACATGGCTCCCTGCATGAGAGCATTTTTGGAGCGGCTCCCCATGATGCTTCAGGAGCAGTA
TGCCTATGAAAAGCCTCATGTGGTTTGTGGTGACCAACTTGTTCATAGCCCCTATATGCAATGCTTGGCTTCCCTTGCTGTGGGACTTCA
TCTGGATCAGCTGTTGTGTAACCCTCCAGTGCCACCACACCACCAGAACTGTCTCCCTGACCCTGCATCCTGGAATCCAAATGAATGGGC
CTGGTTAGAATGTTTCTCAACCACTATAAAAGCTGCCGAAGCCCTGACCAATGGAGCCCAGTTTCCAGAATCTTTTACCGTTCCAGATCT
AGAACCTGTTCCAGAGGATGAACTTGTATTTCTAATGGATAACAGTAAATGGATTAACGGCATGGATGAACAAATTATGTCTTGGGCAAC
TTCCAGACCTGAGGACTGGCACCTGGGAGGTAAATGTGATGTCTACTTATGGGGTGCTGGTAGGCATGGACAGCTGGCAGAAGCTGGAAG
AAATGTAATGGTACCTGCAGCAGCTCCCTCATTCTCACAGGCCCAACAGGTCATTTGTGGTCAGAATTGTACCTTTGTCATCCAGGCCAA
TGGCACAGTGTTGGCTTGTGGGGAAGGAAGTTATGGCAGATTAGGACAAGGAAATTCAGATGACCTTCATGTGCTGACAGTTATTTCAGC
CTTACAAGGCTTTGTGGTGACCCAGCTGGTGACTTCCTGTGGTTCTGATGGGCACTCTATGGCCCTAACTGAAAGTGGTGAGGTCTTTAG
CTGGGGAGATGGTGACTATGGTAAACTTGGCCATGGGAACAGCGACAGGCAGCGGCGGCCCAGGCAGATCGAGGCCTTACAAGGAGAAGA
AGTGGTGCAGATGTCTTGTGGCTTCAAGCACTCAGCAGTGGTCACTTCAGATGGCAAACTGTTCACCTTTGGGAATGGTGACTATGGTCG
TCTGGGTCTTGGAAATACCTCTAACAAAAAACTTCCAGAGAGAGTGACTGCACTGGAGGGATATCAGATTGGACAGGTGGCCTGTGGATT
AAACCACACTTTGGCAGTGTCAGCAGATGGTTCCATGGTGTGGGCTTTTGGAGATGGAGACTATGGAAAACTAGGCTTAGGAAATTCCAC
TGCAAAATCTTCACCTCAGAAAATTGACGTCCTTTGTGGAATTGGAATAAAAAAGGTTGCTTGTGGAACTCAGTTTTCTGTTGCTTTGAC
CAAAGATGGTCATGTGTATACCTTTGGTCAAGATCGCCTGATAGGCTTGCCAGAGGGGCGTGCTCGCAATCACAATCGACCGCAACAAAT
CCCTGTCCTGGCTGGAGTAATCATAGAAGATGTGGCAGTTGGAGCTGAACACACACTTGCTTTGGCATCAAATGGAGATGTGTATGCCTG
GGGGAGCAATTCAGAAGGGCAGCTCGGCTTAGGCCATACCAACCATGTTCGAGAACCAACCCTGGTAACAGGTCTGCAAGGGAAAAATGT
TCGGCAGATCTCGGCTGGCCGCTGCCACAGTGCTGCATGGACAGCACCACCTGTCCCACCAAGAGCACCAGGTGTGTCAGTACCTCTGCA
GCTGGGCCTGCCTGACACAGTGCCCCCCCAGTATGGGGCGCTGAGAGAAGTCAGCATTCACACGGTGCGGGCCAGGCTCCGGCTGCTCTA
CCACTTCTCTGACCTCATGTACTCATCCTGGAGACTGCTGAACCTTAGCCCCAACAACCAGAACAGCACATCCCATTATAATGCTGGAAC
TTGGGGCATTGTACAGGGACAACTTCGGCCTTTGTTAGCCCCAAGAGTCTACACTCTGCCAATGGTGCGCTCCATAGGAAAAACCATGGT
TCAAGGCAAAAACTATGGACCTCAGATAACTGTAAAGAGGATATCAACCAGAGGACGGAAGTGTAAGCCTATTTTTGTCCAAATAGCGAG
ACAAGTAGTTAAGCTGAATGCTTCAGACCTCCGCCTGCCTTCCCGAGCGTGGAAGGTTAAGCTGGTTGGAGAAGGGGCTGATGATGCTGG
AGGAGTGTTTGATGACACCATCACAGAGATGTGCCAGGAACTTGAAACTGGTATTGTTGACCTTCTTATACCCTCTCCCAATGCCACCGC
AGAAGTGGGTTACAATAGGGACAGGTTCCTTTTTAACCCTTCTGCCTGCCTCGATGAACACTTAATGCAGTTTAAGTTTTTAGGAATTTT
AATGGGGGTTGCCATTCGCACAAAGAAGCCTCTGGACCTCCACTTGGCCCCTCTGGTGTGGAAGCAGCTGTGCTGTGTCCCACTCACCCT
AGAGGACCTGGAGGAGGTGGATCTGCTCTACGTGCAGACTCTCAACAGCATTCTTCACATTGAAGACAGTGGGATTACCGAGGAGAGTTT
CCATGAGATGATTCCTCTTGATTCTTTTGTTGGCCAGAGTGCTGATGGCAAAATGGTTCCTATAATCCCTGGTGGAAATAGTATCCCACT
CACATTTTCCAACAGGAAGGAATATGTGGAGAGGGCCATTGAATATCGACTTCATGAGATGGACAGACAGGTGGCTGCAGTCCGAGAAGG
GATGTCCTGGATTGTTCCTGTGCCGCTGCTGTCCCTCCTCACAGCAAAACAACTGGAGCAGATGGTGTGTGGGATGCCCGAGATCTCTGT
GGAAGTCTTGAAGAAAGTGGTGCGGTACCGTGAGGTGGATGAGCAGCATCAGCTGGTGCAGTGGTTCTGGCACACGCTGGAAGAGTTCTC
CAATGAGGAGCGGGTGCTTTTCATGAGGTTTGTGTCAGGAAGATCTCGACTACCAGCCAACACTGCTGACATTTCTCAGAGATTTCAAAT
CATGAAGGTTGATAGGCCTTACGACAGTCTGCCTACCTCACAGACCTGCTTCTTCCAGCTGAGGCTGCCCCCGTACTCCAGCCAGCTGGT
CATGGCCGAGCGCCTGCGCTATGCCATCAACAACTGCCGCTCAATCGACATGGACAACTACATGCTCTCGAGAAACGTGGACAACGCCGA
GGGCTCCGACACTGACTACTGACCGTGCGGGTGCTCTCACCCTCCCTTCTCTCCCTCAATAATGCTCACTTCTGATTTGATGTTGATATA
CTTTTATGGTAACTACATAGATGTTATAAGAACATAAACCAACATTATAAACAATGGCCACATTTAGTTACTCTAAATGTAACAAAGAAA
TTAGATGTTTTTATTTTTCTGTGATTGTACAAAAACAACAAAAACGAAGTGCTCTCAGTCAGGTTTTTCCCTCCATATTTTTGGTCACTT
TTGATAAGTTTGCATGAAACCATTTTGGTGCATTTTTAGTTGGGAATGGTACATTTTTGTAAATCCACCCAGTGAACATGAAATTGTACA
TTGTGTATAATTGTTCATTAGAAAGGACAGTTTTACATGAATATTCATATATTTATTTTGTTTTAATTTGAATTGCCTGTTCAGGGTTCC

>97461_97461_3_USP3-HERC1_USP3_chr15_63797029_ENST00000540797_HERC1_chr15_63955403_ENST00000443617_length(amino acids)=2045AA_BP=1218
MTQGLETQPPSAERPARSDTRRSLRSSSAPTSPGPGAAVLPAALLVAMECPHLSSSVCIAPDSAKFPNGSPSSWCCSAGLYRSVQAHRNQ
SRREGISLQQDPGALYDFNLDEELEIDLDDEAMEAMFGQDLTSDNDILGMWIPEVLDWPTWHVCESEDREEVVVCELCECSVVSFNQHMK
RNHPGCGRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKGQAPDLIGKQDSVYEEDWDMLDVDEDE
KLTGEEEFELLAGPLGLNDRRIVPEPVQFPDSDPLGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRR
VTAAAQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSPSAMASTSERSRGGHSKANKPISCLAYL
STAVGCLASNAPSAAKLLVQLCTQNLISAATGVNLTTVDDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNYDKS
EVEKKGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTTLQTLADMGGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATS
GNDGTIRVWNVTKKQYSLQQTCVFNRLEGDAEESLGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQPHWVSALAWPEE
GPATAWSGESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLEKGGIVLIDAHK
DTLISMKWDPTGHILMTCAKEDSVKLWGSISGCWCCLHSLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTS
AEGWWEQESNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAAC
SNRSKDVLVVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHL
DQLLCNPPVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATS
RPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISAL
QGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL
GLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTK
DGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVR
QISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDTVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTW
GIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGG
VFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLE
DLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGM
SWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIM

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Fusion Gene PPI Analysis for USP3-HERC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP3-HERC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP3-HERC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource