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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP47-RRAS2 (FusionGDB2 ID:97509)

Fusion Gene Summary for USP47-RRAS2

check button Fusion gene summary
Fusion gene informationFusion gene name: USP47-RRAS2
Fusion gene ID: 97509
HgeneTgene
Gene symbol

USP47

RRAS2

Gene ID

55031

22800

Gene nameubiquitin specific peptidase 47RAS related 2
SynonymsTRFPNS12|TC21
Cytomap

11p15.3

11p15.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 47Trf (TATA binding protein-related factor)-proximal homologdeubiquitinating enzyme 47ubiquitin thioesterase 47ubiquitin thiolesterase 47ubiquitin-specific-processing protease 47ras-related protein R-Ras2ras-like protein TC21related RAS viral (r-ras) oncogene homolog 2teratocarcinoma oncogene
Modification date2020031320200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000339865, ENST00000399455, 
ENST00000527733, ENST00000539466, 
ENST00000305481, 		ENST00000256196, 
ENST00000526063, ENST00000529237, 
ENST00000532814, ENST00000534746, 
ENST00000414023, ENST00000537760, 
ENST00000545643, 
Fusion gene scores* DoF score9 X 6 X 5=2705 X 2 X 5=50
# samples 95
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: USP47 [Title/Abstract] AND RRAS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP47(11863771)-RRAS2(14317401), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP47

GO:0035520

monoubiquitinated protein deubiquitination

21362556


check buttonFusion gene breakpoints across USP47 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RRAS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A82C-01AUSP47chr11

11863771

-RRAS2chr11

14317401

-
ChimerDB4SKCMTCGA-EB-A82C-01AUSP47chr11

11863771

+RRAS2chr11

14317401

-
ChimerDB4SKCMTCGA-EB-A82CUSP47chr11

11863771

+RRAS2chr11

14317401

-


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Fusion Gene ORF analysis for USP47-RRAS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000339865ENST00000256196USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000339865ENST00000526063USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000339865ENST00000529237USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000339865ENST00000532814USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000339865ENST00000534746USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000399455ENST00000256196USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000399455ENST00000526063USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000399455ENST00000529237USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000399455ENST00000532814USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000399455ENST00000534746USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000527733ENST00000256196USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000527733ENST00000526063USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000527733ENST00000529237USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000527733ENST00000532814USP47chr11

11863771

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000527733ENST00000534746USP47chr11

11863771

+RRAS2chr11

14317401

-
5UTR-3CDSENST00000539466ENST00000414023USP47chr11

11863771

+RRAS2chr11

14317401

-
5UTR-3CDSENST00000539466ENST00000537760USP47chr11

11863771

+RRAS2chr11

14317401

-
5UTR-3CDSENST00000539466ENST00000545643USP47chr11

11863771

+RRAS2chr11

14317401

-
5UTR-5UTRENST00000539466ENST00000256196USP47chr11

11863771

+RRAS2chr11

14317401

-
5UTR-5UTRENST00000539466ENST00000526063USP47chr11

11863771

+RRAS2chr11

14317401

-
5UTR-5UTRENST00000539466ENST00000529237USP47chr11

11863771

+RRAS2chr11

14317401

-
5UTR-5UTRENST00000539466ENST00000532814USP47chr11

11863771

+RRAS2chr11

14317401

-
5UTR-5UTRENST00000539466ENST00000534746USP47chr11

11863771

+RRAS2chr11

14317401

-
In-frameENST00000339865ENST00000414023USP47chr11

11863771

+RRAS2chr11

14317401

-
In-frameENST00000339865ENST00000537760USP47chr11

11863771

+RRAS2chr11

14317401

-
In-frameENST00000339865ENST00000545643USP47chr11

11863771

+RRAS2chr11

14317401

-
In-frameENST00000399455ENST00000414023USP47chr11

11863771

+RRAS2chr11

14317401

-
In-frameENST00000399455ENST00000537760USP47chr11

11863771

+RRAS2chr11

14317401

-
In-frameENST00000399455ENST00000545643USP47chr11

11863771

+RRAS2chr11

14317401

-
In-frameENST00000527733ENST00000414023USP47chr11

11863771

+RRAS2chr11

14317401

-
In-frameENST00000527733ENST00000537760USP47chr11

11863771

+RRAS2chr11

14317401

-
In-frameENST00000527733ENST00000545643USP47chr11

11863771

+RRAS2chr11

14317401

-
intron-3CDSENST00000305481ENST00000414023USP47chr11

11863771

+RRAS2chr11

14317401

-
intron-3CDSENST00000305481ENST00000537760USP47chr11

11863771

+RRAS2chr11

14317401

-
intron-3CDSENST00000305481ENST00000545643USP47chr11

11863771

+RRAS2chr11

14317401

-
intron-5UTRENST00000305481ENST00000256196USP47chr11

11863771

+RRAS2chr11

14317401

-
intron-5UTRENST00000305481ENST00000526063USP47chr11

11863771

+RRAS2chr11

14317401

-
intron-5UTRENST00000305481ENST00000529237USP47chr11

11863771

+RRAS2chr11

14317401

-
intron-5UTRENST00000305481ENST00000532814USP47chr11

11863771

+RRAS2chr11

14317401

-
intron-5UTRENST00000305481ENST00000534746USP47chr11

11863771

+RRAS2chr11

14317401

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339865USP47chr1111863771+ENST00000545643RRAS2chr1114317401-2720802842417141
ENST00000339865USP47chr1111863771+ENST00000537760RRAS2chr1114317401-27208027631308181
ENST00000339865USP47chr1111863771+ENST00000414023RRAS2chr1114317401-26868026741312212
ENST00000527733USP47chr1111863771+ENST00000545643RRAS2chr1114317401-21682502133190376
ENST00000527733USP47chr1111863771+ENST00000537760RRAS2chr1114317401-2168250211756181
ENST00000527733USP47chr1111863771+ENST00000414023RRAS2chr1114317401-2134250122760212
ENST00000399455USP47chr1111863771+ENST00000545643RRAS2chr1114317401-20771592042181276
ENST00000399455USP47chr1111863771+ENST00000537760RRAS2chr1114317401-2077159120665181
ENST00000399455USP47chr1111863771+ENST00000414023RRAS2chr1114317401-204315931669212

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339865ENST00000545643USP47chr1111863771+RRAS2chr1114317401-0.92074960.07925042
ENST00000339865ENST00000537760USP47chr1111863771+RRAS2chr1114317401-0.0006046990.99939525
ENST00000339865ENST00000414023USP47chr1111863771+RRAS2chr1114317401-0.0097795020.9902204
ENST00000527733ENST00000545643USP47chr1111863771+RRAS2chr1114317401-0.0566784370.9433216
ENST00000527733ENST00000537760USP47chr1111863771+RRAS2chr1114317401-0.0004661210.9995339
ENST00000527733ENST00000414023USP47chr1111863771+RRAS2chr1114317401-0.0038504530.99614954
ENST00000399455ENST00000545643USP47chr1111863771+RRAS2chr1114317401-0.126258250.8737418
ENST00000399455ENST00000537760USP47chr1111863771+RRAS2chr1114317401-0.0003302960.9996697
ENST00000399455ENST00000414023USP47chr1111863771+RRAS2chr1114317401-0.0054254690.9945746

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Fusion Genomic Features for USP47-RRAS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP47-RRAS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:11863771/chr11:14317401)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRRAS2chr11:11863771chr11:14317401ENST000002561960643_5136205.0MotifNote=Effector region
TgeneRRAS2chr11:11863771chr11:14317401ENST00000414023-1543_510128.0MotifNote=Effector region
TgeneRRAS2chr11:11863771chr11:14317401ENST000005260630643_510128.0MotifNote=Effector region
TgeneRRAS2chr11:11863771chr11:14317401ENST000005292370643_510128.0MotifNote=Effector region
TgeneRRAS2chr11:11863771chr11:14317401ENST000005328140643_510128.0MotifNote=Effector region
TgeneRRAS2chr11:11863771chr11:14317401ENST000005347460643_510128.0MotifNote=Effector region
TgeneRRAS2chr11:11863771chr11:14317401ENST000005377600643_511170.0MotifNote=Effector region
TgeneRRAS2chr11:11863771chr11:14317401ENST0000025619606127_13036205.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST0000025619606157_15936205.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST000002561960668_7236205.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST00000414023-15127_1300128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST00000414023-15157_1590128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST00000414023-1521_290128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST00000414023-1568_720128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST0000052606306127_1300128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST0000052606306157_1590128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST000005260630621_290128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST000005260630668_720128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST0000052923706127_1300128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST0000052923706157_1590128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST000005292370621_290128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST000005292370668_720128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST0000053281406127_1300128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST0000053281406157_1590128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST000005328140621_290128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST000005328140668_720128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST0000053474606127_1300128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST0000053474606157_1590128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST000005347460621_290128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST000005347460668_720128.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST0000053776006127_1301170.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST0000053776006157_1591170.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST000005377600621_291170.0Nucleotide bindingGTP
TgeneRRAS2chr11:11863771chr11:14317401ENST000005377600668_721170.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP47chr11:11863771chr11:14317401ENST00000339865+127188_564131288.0DomainNote=USP
HgeneUSP47chr11:11863771chr11:14317401ENST00000399455+129188_564131376.0DomainNote=USP
HgeneUSP47chr11:11863771chr11:14317401ENST00000539466+128188_5640158.0DomainNote=USP
TgeneRRAS2chr11:11863771chr11:14317401ENST000002561960621_2936205.0Nucleotide bindingGTP


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Fusion Gene Sequence for USP47-RRAS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97509_97509_1_USP47-RRAS2_USP47_chr11_11863771_ENST00000339865_RRAS2_chr11_14317401_ENST00000414023_length(transcript)=2686nt_BP=802nt
AGAGGGGAAAAGAACGTCAGGAGAGTGAACGGGAGCAAATAAAACGCTGTCCATTCTGACTGGAAGGGCCAGAGCCGTGTCTAAGGGCGG
GGGCCGGGAGGTGGCCCGCGGTGGTGTCTCTACCAGGACGAGGCCTGGGGTATCTGAAGAGGGGATGACGTCCAGGCGCTTTGCTAAAGG
GAAGCCAGAAGGGTATGAGTTGCTAGGGTCAGAGATGGGGCTTTCGGCTCGAGTCTTTCCCTGCAGGGCAGAGAGTCCGAAGAGCCCGAG
AAGGCAGGGAGGACAGTGGGCCTGGTCCTTCCCCGGCCGGCAGAGGGAGTCCCGAGATGGAACGTCCAGCTCTCCTCTAACGAAAAGCGT
TTGCATGGCTGTCTCGCCAATTCTGTACCTCCCGGGGCTGAGGAAGAGCCGAGGTGACTAGAAGCTAGCGACAAGTGCCGGCCACCTCCG
ACGCCAGGCGCCGGGCTTGGAGCCCGACGGGCCGAATTCTCGCGAGAGCGGCCGCCGCCATTTTTCCATTGATTGCAGCGGGCTGGGGGA
GGGGCCGACGACGAAGGCGGCTGTGGTAGCGGCGGCGGCGGCGGCGGAGCCCTGGGTCGGTGTCTGCGCGCTGGTGTCTGAGGCCCAGGC
TGAGGCCTCCGCTATTGCTGGAGCGCAGGCGGCGGAGAGGATGACTGCCGCTGCCATTCTCTCTTGAGCTAGCGAGCCGCCGCCACCCTC
CACCCTCCCCCGGCAGGGCGGAGAGGAGCGGCCGGAGTCAGCGATGGTGCCCGGCGAGGAGAACCAACTGGTCCCGAAAGAGGCAGTCCT
ATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGG
ATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATA
GAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATA
AAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAG
CAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAG
AACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAG
CCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAG
AAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTG
ATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAA
GCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGG
GTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAG
TGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACT
GCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATAT
TTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGT
ATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAA
TGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAG
CATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTG
TGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTAC
AACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAA
TTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATG

>97509_97509_1_USP47-RRAS2_USP47_chr11_11863771_ENST00000339865_RRAS2_chr11_14317401_ENST00000414023_length(amino acids)=212AA_BP=43
MPLPFSLELASRRHPPPSPGRAERSGRSQRWCPARRTNWSRKRQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQY
MRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELV

--------------------------------------------------------------
>97509_97509_2_USP47-RRAS2_USP47_chr11_11863771_ENST00000339865_RRAS2_chr11_14317401_ENST00000537760_length(transcript)=2720nt_BP=802nt
AGAGGGGAAAAGAACGTCAGGAGAGTGAACGGGAGCAAATAAAACGCTGTCCATTCTGACTGGAAGGGCCAGAGCCGTGTCTAAGGGCGG
GGGCCGGGAGGTGGCCCGCGGTGGTGTCTCTACCAGGACGAGGCCTGGGGTATCTGAAGAGGGGATGACGTCCAGGCGCTTTGCTAAAGG
GAAGCCAGAAGGGTATGAGTTGCTAGGGTCAGAGATGGGGCTTTCGGCTCGAGTCTTTCCCTGCAGGGCAGAGAGTCCGAAGAGCCCGAG
AAGGCAGGGAGGACAGTGGGCCTGGTCCTTCCCCGGCCGGCAGAGGGAGTCCCGAGATGGAACGTCCAGCTCTCCTCTAACGAAAAGCGT
TTGCATGGCTGTCTCGCCAATTCTGTACCTCCCGGGGCTGAGGAAGAGCCGAGGTGACTAGAAGCTAGCGACAAGTGCCGGCCACCTCCG
ACGCCAGGCGCCGGGCTTGGAGCCCGACGGGCCGAATTCTCGCGAGAGCGGCCGCCGCCATTTTTCCATTGATTGCAGCGGGCTGGGGGA
GGGGCCGACGACGAAGGCGGCTGTGGTAGCGGCGGCGGCGGCGGCGGAGCCCTGGGTCGGTGTCTGCGCGCTGGTGTCTGAGGCCCAGGC
TGAGGCCTCCGCTATTGCTGGAGCGCAGGCGGCGGAGAGGATGACTGCCGCTGCCATTCTCTCTTGAGCTAGCGAGCCGCCGCCACCCTC
CACCCTCCCCCGGCAGGGCGGAGAGGAGCGGCCGGAGTCAGCGATGGTGCCCGGCGAGGAGAACCAACTGGTCCCGAAAGAGTCCTATTT
TGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATAC
AGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGG
CAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGC
AGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAA
GATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACC
AACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCT
CATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGC
TGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTC
CTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTG
TTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTT
TTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAA
CCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTT
ATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCA
GTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTT
CTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTT
TTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATA
CCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGT
AGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACA
GGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAG
TATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAA
GTGGTATTGCACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTTTATAGAGCATACCCTTGTATAGCTTCAGGTGCTAGA

>97509_97509_2_USP47-RRAS2_USP47_chr11_11863771_ENST00000339865_RRAS2_chr11_14317401_ENST00000537760_length(amino acids)=181AA_BP=13
MVPGEENQLVPKESYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILR
VKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPSPEPTRKEKDKKGCHCVI

--------------------------------------------------------------
>97509_97509_3_USP47-RRAS2_USP47_chr11_11863771_ENST00000339865_RRAS2_chr11_14317401_ENST00000545643_length(transcript)=2720nt_BP=802nt
AGAGGGGAAAAGAACGTCAGGAGAGTGAACGGGAGCAAATAAAACGCTGTCCATTCTGACTGGAAGGGCCAGAGCCGTGTCTAAGGGCGG
GGGCCGGGAGGTGGCCCGCGGTGGTGTCTCTACCAGGACGAGGCCTGGGGTATCTGAAGAGGGGATGACGTCCAGGCGCTTTGCTAAAGG
GAAGCCAGAAGGGTATGAGTTGCTAGGGTCAGAGATGGGGCTTTCGGCTCGAGTCTTTCCCTGCAGGGCAGAGAGTCCGAAGAGCCCGAG
AAGGCAGGGAGGACAGTGGGCCTGGTCCTTCCCCGGCCGGCAGAGGGAGTCCCGAGATGGAACGTCCAGCTCTCCTCTAACGAAAAGCGT
TTGCATGGCTGTCTCGCCAATTCTGTACCTCCCGGGGCTGAGGAAGAGCCGAGGTGACTAGAAGCTAGCGACAAGTGCCGGCCACCTCCG
ACGCCAGGCGCCGGGCTTGGAGCCCGACGGGCCGAATTCTCGCGAGAGCGGCCGCCGCCATTTTTCCATTGATTGCAGCGGGCTGGGGGA
GGGGCCGACGACGAAGGCGGCTGTGGTAGCGGCGGCGGCGGCGGCGGAGCCCTGGGTCGGTGTCTGCGCGCTGGTGTCTGAGGCCCAGGC
TGAGGCCTCCGCTATTGCTGGAGCGCAGGCGGCGGAGAGGATGACTGCCGCTGCCATTCTCTCTTGAGCTAGCGAGCCGCCGCCACCCTC
CACCCTCCCCCGGCAGGGCGGAGAGGAGCGGCCGGAGTCAGCGATGGTGCCCGGCGAGGAGAACCAACTGGTCCCGAAAGAGGAAATTTC
AAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCA
GTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAA
TGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAA
CACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAA
TAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCC
TACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTT
AAATACACTGAATTGAATCTACAAAAGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAAT
GCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAAT
ATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAAT
AATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATT
GATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATA
TGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAG
AAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACT
ACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAG
TATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATT
CAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATTGCACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTTTATAG
AGCATACCCTTGTATAGCTTCAGGTGCTAGAATTAAAATTGATCTGTTATCGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTT
AAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGTTTTGAAGAA
ATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCAT
CAAAGACAGTTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCT
TTTCAGTCACAGATAGAGGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGA

>97509_97509_3_USP47-RRAS2_USP47_chr11_11863771_ENST00000339865_RRAS2_chr11_14317401_ENST00000545643_length(amino acids)=141AA_BP=
MVLVKEDIPALEISSFGTSWFSSPGTIADSGRSSPPCRGRVEGGGGSLAQERMAAAVILSAACAPAIAEASAWASDTSAQTPTQGSAAAA

--------------------------------------------------------------
>97509_97509_4_USP47-RRAS2_USP47_chr11_11863771_ENST00000399455_RRAS2_chr11_14317401_ENST00000414023_length(transcript)=2043nt_BP=159nt
ATTGCTGGAGCGCAGGCGGCGGAGAGGATGACTGCCGCTGCCATTCTCTCTTGAGCTAGCGAGCCGCCGCCACCCTCCACCCTCCCCCGG
CAGGGCGGAGAGGAGCGGCCGGAGTCAGCGATGGTGCCCGGCGAGGAGAACCAACTGGTCCCGAAAGAGGCAGTCCTATTTTGTAACGGA
TTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACA
AGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGA
AGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGA
TCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGAT
GAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAA
AGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCTC
TTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGTC
CTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAAT
ATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAAG
CTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAATG
TGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTCAG
ACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACCC
TGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTTG
ATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAAG
GGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTATA
TACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGTA
TATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTTT
ACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGAC
TCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTGT
GGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATTG

>97509_97509_4_USP47-RRAS2_USP47_chr11_11863771_ENST00000399455_RRAS2_chr11_14317401_ENST00000414023_length(amino acids)=212AA_BP=43
MPLPFSLELASRRHPPPSPGRAERSGRSQRWCPARRTNWSRKRQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQY
MRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELV

--------------------------------------------------------------
>97509_97509_5_USP47-RRAS2_USP47_chr11_11863771_ENST00000399455_RRAS2_chr11_14317401_ENST00000537760_length(transcript)=2077nt_BP=159nt
ATTGCTGGAGCGCAGGCGGCGGAGAGGATGACTGCCGCTGCCATTCTCTCTTGAGCTAGCGAGCCGCCGCCACCCTCCACCCTCCCCCGG
CAGGGCGGAGAGGAGCGGCCGGAGTCAGCGATGGTGCCCGGCGAGGAGAACCAACTGGTCCCGAAAGAGTCCTATTTTGTAACGGATTAT
GATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAA
GAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAA
ATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCAT
CAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAAT
GTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAA
AAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCTCTTTC
TCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGTCCTTT
CTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAATATAT
GTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAAGCTGA
AGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAATGTGAA
TTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTCAGACCT
TTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACCCTGTG
TTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTTGATTT
TTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAAGGGAT
TCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTATATACT
TTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGTATATG
TAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTTTACTT
GCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGACTCTG
AAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTGTGGAT
GGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATTGCACA
GTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTTTATAGAGCATACCCTTGTATAGCTTCAGGTGCTAGAATTAAAATTGATC

>97509_97509_5_USP47-RRAS2_USP47_chr11_11863771_ENST00000399455_RRAS2_chr11_14317401_ENST00000537760_length(amino acids)=181AA_BP=13
MVPGEENQLVPKESYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILR
VKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPSPEPTRKEKDKKGCHCVI

--------------------------------------------------------------
>97509_97509_6_USP47-RRAS2_USP47_chr11_11863771_ENST00000399455_RRAS2_chr11_14317401_ENST00000545643_length(transcript)=2077nt_BP=159nt
ATTGCTGGAGCGCAGGCGGCGGAGAGGATGACTGCCGCTGCCATTCTCTCTTGAGCTAGCGAGCCGCCGCCACCCTCCACCCTCCCCCGG
CAGGGCGGAGAGGAGCGGCCGGAGTCAGCGATGGTGCCCGGCGAGGAGAACCAACTGGTCCCGAAAGAGGAAATTTCAAGAGCAGGAATG
TCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCA
ACGGCCAGGAAAAGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTT
AGCCTTAGACGAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCT
TCAAAGATTATCTGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCA
GTTTTGGAATCTAAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTA
AATAGAAATATAGGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAAT
TGAATCTACAAAAGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTT
ATGGATTAAAAACTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATT
TAGGACTTAGATATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGT
CTTCCTTTTCAAGTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGG
TCAGAGATGATTAATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAG
ATATGCTTTCATAGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGA
AACTACAGAAACTGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCT
TCCCAATAGAGTACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAG
CTTTTAATGGATAATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTC
CTGATTTTGAGATGCTAAGTGGTATTGCACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTTTATAGAGCATACCCTTGT
ATAGCTTCAGGTGCTAGAATTAAAATTGATCTGTTATCGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACA
TGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGTTTTGAAGAAATCTATAAGTTTC
AAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGTTTT
GGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGA
TAGAGGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGG

>97509_97509_6_USP47-RRAS2_USP47_chr11_11863771_ENST00000399455_RRAS2_chr11_14317401_ENST00000545643_length(amino acids)=76AA_BP=1

--------------------------------------------------------------
>97509_97509_7_USP47-RRAS2_USP47_chr11_11863771_ENST00000527733_RRAS2_chr11_14317401_ENST00000414023_length(transcript)=2134nt_BP=250nt
GAAGGCGGCTGTGGTAGCGGCGGCGGCGGCGGCGGAGCCCTGGGTCGGTGTCTGCGCGCTGGTGTCTGAGGCCCAGGCTGAGGCCTCCGC
TATTGCTGGAGCGCAGGCGGCGGAGAGGATGACTGCCGCTGCCATTCTCTCTTGAGCTAGCGAGCCGCCGCCACCCTCCACCCTCCCCCG
GCAGGGCGGAGAGGAGCGGCCGGAGTCAGCGATGGTGCCCGGCGAGGAGAACCAACTGGTCCCGAAAGAGGCAGTCCTATTTTGTAACGG
ATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGAC
AAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTG
AAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGG
ATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGA
TGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGA
AAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCT
CTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGT
CCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAA
TATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAA
GCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAAT
GTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTCA
GACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACC
CTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTT
GATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAA
GGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTAT
ATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGT
ATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTT
TACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGA
CTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTG
TGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATT

>97509_97509_7_USP47-RRAS2_USP47_chr11_11863771_ENST00000527733_RRAS2_chr11_14317401_ENST00000414023_length(amino acids)=212AA_BP=43
MPLPFSLELASRRHPPPSPGRAERSGRSQRWCPARRTNWSRKRQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQY
MRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELV

--------------------------------------------------------------
>97509_97509_8_USP47-RRAS2_USP47_chr11_11863771_ENST00000527733_RRAS2_chr11_14317401_ENST00000537760_length(transcript)=2168nt_BP=250nt
GAAGGCGGCTGTGGTAGCGGCGGCGGCGGCGGCGGAGCCCTGGGTCGGTGTCTGCGCGCTGGTGTCTGAGGCCCAGGCTGAGGCCTCCGC
TATTGCTGGAGCGCAGGCGGCGGAGAGGATGACTGCCGCTGCCATTCTCTCTTGAGCTAGCGAGCCGCCGCCACCCTCCACCCTCCCCCG
GCAGGGCGGAGAGGAGCGGCCGGAGTCAGCGATGGTGCCCGGCGAGGAGAACCAACTGGTCCCGAAAGAGTCCTATTTTGTAACGGATTA
TGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGA
AGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGA
AATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCA
TCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAA
TGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGA
AAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCTCTTT
CTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGTCCTT
TCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAATATA
TGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAAGCTG
AAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAATGTGA
ATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTCAGACC
TTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACCCTGT
GTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTTGATT
TTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAAGGGA
TTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTATATAC
TTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGTATAT
GTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTTTACT
TGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGACTCT
GAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTGTGGA
TGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATTGCAC
AGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTTTATAGAGCATACCCTTGTATAGCTTCAGGTGCTAGAATTAAAATTGAT

>97509_97509_8_USP47-RRAS2_USP47_chr11_11863771_ENST00000527733_RRAS2_chr11_14317401_ENST00000537760_length(amino acids)=181AA_BP=13
MVPGEENQLVPKESYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILR
VKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPSPEPTRKEKDKKGCHCVI

--------------------------------------------------------------
>97509_97509_9_USP47-RRAS2_USP47_chr11_11863771_ENST00000527733_RRAS2_chr11_14317401_ENST00000545643_length(transcript)=2168nt_BP=250nt
GAAGGCGGCTGTGGTAGCGGCGGCGGCGGCGGCGGAGCCCTGGGTCGGTGTCTGCGCGCTGGTGTCTGAGGCCCAGGCTGAGGCCTCCGC
TATTGCTGGAGCGCAGGCGGCGGAGAGGATGACTGCCGCTGCCATTCTCTCTTGAGCTAGCGAGCCGCCGCCACCCTCCACCCTCCCCCG
GCAGGGCGGAGAGGAGCGGCCGGAGTCAGCGATGGTGCCCGGCGAGGAGAACCAACTGGTCCCGAAAGAGGAAATTTCAAGAGCAGGAAT
GTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACC
AACGGCCAGGAAAAGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGT
TAGCCTTAGACGAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGC
TTCAAAGATTATCTGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATC
AGTTTTGGAATCTAAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCT
AAATAGAAATATAGGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAA
TTGAATCTACAAAAGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATT
TATGGATTAAAAACTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCAT
TTAGGACTTAGATATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTG
TCTTCCTTTTCAAGTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGG
GTCAGAGATGATTAATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCA
GATATGCTTTCATAGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGG
AAACTACAGAAACTGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACC
TTCCCAATAGAGTACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAA
GCTTTTAATGGATAATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTT
CCTGATTTTGAGATGCTAAGTGGTATTGCACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTTTATAGAGCATACCCTTG
TATAGCTTCAGGTGCTAGAATTAAAATTGATCTGTTATCGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATAC
ATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGTTTTGAAGAAATCTATAAGTTT
CAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGTTT
TGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAG
ATAGAGGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCG

>97509_97509_9_USP47-RRAS2_USP47_chr11_11863771_ENST00000527733_RRAS2_chr11_14317401_ENST00000545643_length(amino acids)=76AA_BP=1

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USP47-RRAS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP47-RRAS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP47-RRAS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource