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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BIRC6-EML6 (FusionGDB2 ID:9757)

Fusion Gene Summary for BIRC6-EML6

check button Fusion gene summary
Fusion gene informationFusion gene name: BIRC6-EML6
Fusion gene ID: 9757
HgeneTgene
Gene symbol

BIRC6

EML6

Gene ID

57448

400954

Gene namebaculoviral IAP repeat containing 6EMAP like 6
SynonymsAPOLLON|BRUCE-
Cytomap

2p22.3

2p16.1

Type of geneprotein-codingprotein-coding
Descriptionbaculoviral IAP repeat-containing protein 6BIR repeat-containing ubiquitin-conjugating enzymeRING-type E3 ubiquitin transferase BIRC6ubiquitin-conjugating BIR-domain enzyme apollonechinoderm microtubule-associated protein-like 6EMAP-6echinoderm microtubule associated protein like 6
Modification date2020031320200313
UniProtAcc

Q9NR09

Q6ZMW3

Ensembl transtripts involved in fusion geneENST00000421745, ENST00000490828, 
ENST00000356458, 
Fusion gene scores* DoF score21 X 23 X 16=77286 X 6 X 4=144
# samples 336
** MAII scorelog2(33/7728*10)=-4.54955716458996
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BIRC6 [Title/Abstract] AND EML6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBIRC6(32679010)-EML6(55071184), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BIRC6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EML6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KC-A4BL-01ABIRC6chr2

32679010

-EML6chr2

55071184

+


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Fusion Gene ORF analysis for BIRC6-EML6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000421745ENST00000490828BIRC6chr2

32679010

-EML6chr2

55071184

+
In-frameENST00000421745ENST00000356458BIRC6chr2

32679010

-EML6chr2

55071184

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000421745BIRC6chr232679010-ENST00000356458EML6chr255071184+11840488713499163260

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000421745ENST00000356458BIRC6chr232679010-EML6chr255071184+0.000380340.9996196

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Fusion Genomic Features for BIRC6-EML6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BIRC6-EML6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:32679010/chr2:55071184)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BIRC6

Q9NR09

EML6

Q6ZMW3

FUNCTION: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}.FUNCTION: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBIRC6chr2:32679010chr2:55071184ENST00000421745-237430_3615844858.0Compositional biasNote=Poly-Ala
HgeneBIRC6chr2:32679010chr2:55071184ENST00000421745-2374284_35815844858.0RepeatNote=BIR
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411355_13582821959.0Compositional biasNote=Poly-Lys
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411038_10772821959.0RepeatNote=WD 17
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411080_11202821959.0RepeatNote=WD 18
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411191_12302821959.0RepeatNote=WD 19
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411236_12762821959.0RepeatNote=WD 20
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411412_14562821959.0RepeatNote=WD 21
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411460_15012821959.0RepeatNote=WD 22
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411504_15432821959.0RepeatNote=WD 23
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411553_15912821959.0RepeatNote=WD 24
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411593_16382821959.0RepeatNote=WD 25
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411685_17242821959.0RepeatNote=WD 26
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411726_17672821959.0RepeatNote=WD 27
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411768_18072821959.0RepeatNote=WD 28
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411880_19192821959.0RepeatNote=WD 29
TgeneEML6chr2:32679010chr2:55071184ENST000003564585411925_19582821959.0RepeatNote=WD 30
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541280_3212821959.0RepeatNote=WD 6
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541323_3622821959.0RepeatNote=WD 7
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541364_4032821959.0RepeatNote=WD 8
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541406_4452821959.0RepeatNote=WD 9
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541561_6012821959.0RepeatNote=WD 10
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541725_7662821959.0RepeatNote=WD 11
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541770_8112821959.0RepeatNote=WD 12
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541814_8532821959.0RepeatNote=WD 13
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541861_9002821959.0RepeatNote=WD 14
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541901_9402821959.0RepeatNote=WD 15
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541996_10352821959.0RepeatNote=WD 16

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBIRC6chr2:32679010chr2:55071184ENST00000421745-23741660_166815844858.0Compositional biasNote=Poly-Ala
HgeneBIRC6chr2:32679010chr2:55071184ENST00000421745-23744573_474015844858.0DomainUBC core
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541104_1452821959.0RepeatNote=WD 2
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541148_1872821959.0RepeatNote=WD 3
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541195_2332821959.0RepeatNote=WD 4
TgeneEML6chr2:32679010chr2:55071184ENST00000356458541235_2732821959.0RepeatNote=WD 5
TgeneEML6chr2:32679010chr2:55071184ENST0000035645854159_1002821959.0RepeatNote=WD 1


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Fusion Gene Sequence for BIRC6-EML6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9757_9757_1_BIRC6-EML6_BIRC6_chr2_32679010_ENST00000421745_EML6_chr2_55071184_ENST00000356458_length(transcript)=11840nt_BP=4887nt
TCCCTGCTTCTCCCCCTCTCCCGTCAGCCTCCCTCCGAGTTTGGCCCCTCCGGCCGGGCGATCGACGTTCCGCGTGCGTGCGGGCGCCTG
ACTTCACTTCCGGCTAACGCGCTCGGCTTGCCCCCTGGCCCCGGATGGTGACTGGTGGTGGTGCTGCACCTCCCGGGACTGTCACTGAGC
CGCTTCCCAGTGTGATTGTGCTGAGCGCAGGCCGGAAGATGGCGGCTGCGGCTGCGGCGGCCTCGGGCCCCGGCTGCTCCTCGGCGGCGG
GGGCGGGGGCGGCCGGGGTCTCAGAGTGGCTGGTGCTGCGGGACGGCTGCATGCACTGCGACGCCGACGGGCTGCACAGCCTGTCCTACC
ACCCTGCGCTCAACGCCATCCTGGCCGTCACTAGCCGCGGGACCATCAAAGTCATCGACGGCACCTCGGGGGCCACACTGCAGGCCTCCG
CGCTCAGTGCTAAACCAGGTGGACAGGTGAAATGTCAGTATATCTCTGCTGTGGATAAAGTTATATTTGTGGATGATTATGCAGTAGGGT
GTAGGAAGGACCTTAATGGAATCTTGTTGTTAGACACTGCTCTGCAAACTCCAGTTTCAAAGCAGGATGATGTGGTTCAGCTTGAATTAC
CCGTTACAGAGGCACAGCAGCTCTTATCAGCATGTTTAGAAAAGGTAGATATTTCTAGTACAGAGGGTTATGATTTGTTCATCACACAGC
TCAAAGATGGTTTAAAAAATACATCTCATGAGACTGCAGCAAACCACAAAGTTGCTAAGTGGGCCACAGTTACATTTCATCTTCCTCATC
ATGTGTTGAAGTCCATTGCCAGTGCCATTGTAAATGAACTCAAGAAAATAAATCAAAATGTTGCTGCCTTACCTGTGGCGTCCTCAGTGA
TGGACAGATTGTCTTACCTCTTACCTAGTGCACGTCCAGAACTCGGAGTGGGGCCAGGCCGTTCTGTAGACAGATCACTGATGTATAGTG
AAGCTAACAGACGGGAGACATTTACCTCATGGCCTCATGTAGGCTATAGGTGGGCACAACCAGATCCCATGGCTCAAGCTGGATTTTATC
ATCAGCCTGCCTCATCTGGAGATGATAGAGCCATGTGTTTTACTTGTAGTGTATGCCTCGTTTGTTGGGAACCTACTGATGAACCTTGGT
CTGAACACGAAAGACATTCCCCAAACTGCCCATTTGTGAAAGGTGAGCACACACAGAATGTGCCATTGTCAGTCACTCTTGCAACAAGTC
CTGCACAGTTTCCTTGTACGGATGGAACTGACAGAATATCTTGCTTTGGGTCGGGGAGCTGCCCTCATTTTCTAGCTGCTGCAACTAAAC
GAGGAAAGATCTGCATATGGGATGTTTCCAAACTTATGAAGGTGCACTTAAAGTTTGAAATTAATGCCTATGATCCAGCAATTGTACAAC
AGCTTATTCTATCAGGAGACCCAAGCTCAGGAGTTGATTCAAGGAGACCAACTTTGGCGTGGCTGGAGGACTCCTCTAGTTGCTCAGATA
TACCAAAATTGGAAGGAGATAGTGATGATTTACTGGAGGATTCAGACAGTGAAGAGCATTCCAGATCAGATTCTGTGACAGGGCATACAT
CACAGAAGGAAGCCATGGAAGTAAGCCTTGATATAACAGCACTCAGCATTCTCCAACAGCCAGAAAAACTTCAGTGGGAGATTGTTGCAA
ATGTGCTTGAAGATACTGTTAAGGATCTTGAAGAACTTGGGGCAAATCCTTGTTTAACAAACTCTAAGAGTGAAAAGACAAAGGAAAAGC
ACCAGGAGCAACACAACATTCCTTTTCCATGTTTATTAGCTGGAGGTTTATTAACATATAAATCTCCTGCTACCTCACCCATTAGTAGTA
ATTCTCACAGGTCACTGGATGGTTTAAGCAGAACTCAGGGTGAAAGTATATCAGAACAAGGGTCAACTGACAATGAATCCTGCACTAATT
CAGAACTAAATTCTCCTCTGGTAAGGAGGACTTTACCGGTTTTGCTTCTTTATAGCATCAAGGAATCTGATGAGAAAGCAGGAAAGATCT
TTTCACAGATGAACAATATTATGAGTAAAAGTTTGCATGATGATGGTTTTACTGTTCCACAGATTATTGAAATGGAGCTGGATAGTCAGG
AGCAGTTGTTATTGCAGGATCCTCCTGTGACTTACATTCAGCAATTTGCAGATGCAGCAGCCAACCTTACCTCTCCGGATTCTGAGAAGT
GGAACTCTGTGTTTCCCAAGCCTGGGACTTTGGTTCAGTGCTTGAGGCTGCCAAAGTTTGCAGAGGAGGAGAATCTTTGTATAGACTCAA
TAACTCCTTGTGCTGACGGAATTCATTTGTTGGTAGGACTGCGGACATGCCCTGTTGAATCCTTGAGTGCAATAAATCAAGTAGAGGCCT
TGAATAATTTAAATAAATTAAACTCTGCACTATGTAATAGACGGAAAGGTGAGCTGGAATCAAATCTTGCTGTAGTGAATGGTGCAAATA
TTAGTGTAATCCAACATGAATCACCAGCAGATGTACAGACTCCTTTAATAATTCAGCCTGAGCAGAGGAATGTTAGTGGTGGATATTTAG
TGCTTTATAAAATGAATTATGCCACTCGGATAGTGACTTTAGAAGAGGAGCCAATAAAAATACAACATATCAAAGATCCCCAGGACACAA
TTACCTCGCTCATTTTGCTTCCACCCGATATATTGGATAATCGAGAGGATGACTGTGAGGAACCTATTGAGGACATGCAGTTAACCTCAA
AGAATGGTTTTGAGAGAGAAAAAACGTCTGACATTTCTACTCTTGGACACCTGGTAATAACCACTCAGGGAGGATATGTAAAAATACTAG
ATCTTTCAAACTTTGAAATTTTGGCCAAAGTGGAGCCTCCCAAAAAGGAGGGCACTGAGGAACAGGACACATTTGTTTCTGTGATTTACT
GTTCTGGCACAGACAGGCTGTGTGCATGCACCAAAGGTGGTGAGCTTCATTTTCTCCAAATTGGAGGAACCTGTGATGATATTGATGAAG
CTGATATACTAGTGGATGGATCTCTTTCTAAAGGAATAGAACCATCTTCAGAAGGTTCCAAACCTTTATCAAATCCTTCAAGTCCTGGCA
TTTCAGGAGTTGATTTATTGGTGGACCAGCCATTCACCCTTGAAATCTTGACATCCCTAGTGGAGCTAACCCGCTTTGAGACTTTGACTC
CAAGGTTTTCAGCGACTGTTCCTCCATGCTGGGTAGAAGTTCAACAAGAACAGCAGCAAAGGAGGCATCCTCAACATTTGCATCAGCAAC
ACCATGGTGATGCTGCTCAGCATACTCGAACTTGGAAACTACAGACCGACAGCAACAGCTGGGATGAACATGTATTTGAATTAGTACTAC
CTAAAGCTTGTATGGTTGGACATGTGGACTTCAAATTCGTTTTGAACTCAAACATCACCAATATTCCACAGATACAAGTGACACTGCTGA
AAAATAAAGCTCCAGGATTAGGGAAAGTCAATGCTCTTAACATTGAAGTGGAACAAAATGGGAAACCGTCCCTGGTTGATTTGAATGAAG
AAATGCAGCACATGGATGTAGAGGAATCACAGTGTCTTAGATTATGTCCATTTTTGGAGGATCATAAAGAAGACATTCTATGTGGGCCAG
TATGGCTTGCTAGTGGCCTTGATCTATCAGGGCATGCTGGAATGTTGACGTTAACAAGCCCCAAACTTGTTAAAGGTATGGCAGGAGGAA
AATATCGTTCGTTTTTAATCCATGTCAAGGCAGTGAATGAAAGAGGAACAGAAGAGATTTGTAATGGTGGTATGCGTCCTGTAGTAAGGC
TTCCATCCCTAAAACACCAGAGTAACAAGGGTTATTCACTTGCTTCACTTTTGGCTAAAGTTGCAGCAGGCAAGGAAAAATCATCTAATG
TTAAGAATGAAAATACAAGTGGCACCCGTAAATCTGAAAACCTCCGGGGCTGTGATTTACTTCAAGAGGTCTCAGTCACCATTCGAAGAT
TTAAGAAAACCTCAATTTCTAAGGAAAGAGTGCAACGATGTGCCATGTTACAGTTTTCAGAATTTCATGAGAAGCTTGTTAATACTCTTT
GCAGAAAAACAGATGATGGCCAGATCACAGAACATGCCCAGAGCCTTGTGTTGGATACTCTCTGTTGGTTAGCTGGAGTTCATTCAAATG
GACCCGGAAGCTCAAAGGAAGGAAATGAGAACCTACTTTCAAAAACACGAAAATTTCTGTCAGACATCGTACGTGTTTGCTTCTTTGAGG
CAGGACGAAGTATAGCCCATAAGTGTGCCCGATTTCTAGCCTTGTGCATTAGTAATGGCAAATGTGACCCATGTCAACCAGCATTTGGAC
CTGTTCTGTTGAAGGCTTTACTTGATAATATGTCATTTTTACCTGCAGCAACAACTGGTGGTTCTGTCTATTGGTATTTTGTCTTACTGA
ATTATGTGAAAGATGAAGATCTGGCTGGATGCAGTACAGCTTGTGCATCTTTGCTTACTGCAGTGTCCAGACAGTTACAGGACAGGCTAA
CACCAATGGAGGCTTTACTTCAGACAAGATATGGATTATATAGCTCACCATTTGATCCAGTCCTCTTTGATTTGGAGATGAGTGGCTCTT
CTTGTAAAAATGTTTATAACAGCAGCATTGGTGTCCAGTCAGATGAAATTGATTTATCAGATGTCCTTTCAGGAAATGGAAAGGTCAGTA
GTTGCACAGCTGCTGAGGGTAGTTTCACATCTCTCACTGGACTTTTGGAAGTTGAACCTCTGCACTTTACTTGTGTGTCAACTAGTGATG
GAACCAGAATAGAAAGGGATGATGCAAGCCTCTCTATCCGGAGCGTGTGCTGGAAAGCAGACCGCCTTCTAGCAGGGACCCAGGACAGTG
AGATATTTGAAGTGATTGTGCGAGAGCGAGACAAGCCGATGTTGATCCTACAGGGCCACTGCGAGGGTGAGCTCTGGGCTCTGGCCCTGC
ACCCCAAGAAGCCTCTGGCTGTGACAGGCAGCGATGACCGCTCTGTCAGGCTGTGGAGCCTGGCTGATCATGCCTTGATCGCCCGCTGTA
ACATGGAAGAGGCGGTTCGCAGTGTAGCTTTCAGCCCCGACGGATCTCAGCTGGCCCTGGGCATGAAGGACGGCTCTTTCATTGTTCTCC
GAGTCAGAGATATGACAGAAGTAGTTCACATCAAAGATCGAAAAGAAGTCATTCATGAAATGAAATTTTCTCCAGATGGTTCTTACCTTG
CAGTGGGATCCAATGATGGCCCAGTAGATGTCTATGCTGTTGCCCAGAGGTATAAGAAAATTGGAGAATGCAGCAAGTCCCTTAGTTTCA
TCACGCATATTGACTGGTCCTTGGATAGTAAATACTTACAAACTAATGACGGTGCAGGAGAACGATTGTTCTACAGAATGCCATCTGGGA
AGCCTTTAACAAGTAAAGAAGAAATTAAAGGGATTCCTTGGGCCTCCTGGACATGCGTGAAAGGCCCTGAAGTGAGTGGAATTTGGCCCA
AATACACTGAGGTTACTGACATCAACTCAGTGGATGCGAATTACAACAGCTCAGTGCTGGTGTCTGGAGATGATTTTGGACTGGTTAAAT
TGTTTAAATTTCCTTGTCTCAAGAGAGGAGCCAAATTTAGAAAGTATGTGGGCCATTCTGCACATGTCACAAATGTCCGCTGGTCCCATG
ACTTTCAGTGGGTGTTGAGCACAGGAGGGGCTGATCACTCAGTTTTCCAGTGGAGGTTTATTCCAGAAGGTGTCAGCAACGGCATGCTGG
AAACTGCACCCCAAGAAGGTGGAGCTGATTCCTACAGTGAAGAATCTGATTCAGATTTATCTGATGTGCCCGAACTGGACTCTGATATTG
AGCAAGAAGCTCAAATCAATTATGATCGCCAGGTTTACAAAGAAGATCTACCTCAGCTAAAGCAACAAAGTAAAGAGAAAAACCACGCAG
TGCCCTTCCTCAAACGAGAAAAGGCTCCTGAGGACAGCTTGAAACTCCAGTTCATACACGGTTATAGAGGCTACGACTGTAGAAACAATC
TGTTCTACACACAAGCTGGAGAAGTAGTCTACCACATTGCTGCAGTTGCTGTCGTGTATAATCGGCAGCAGCACTCCCAGAGGCTGTACC
TGGGGCACGATGACGACATTCTCAGCCTGACCATCCATCCAGTGAAGGACTATGTGGCTACTGGGCAGGTTGGAAGAGATGCTGCTATTC
ATGTGTGGGACACACAAACTCTAAAATGTTTGTCGCTGTTGAAAGGACAACATCAGAGAGGAGTGTGTGCACTTGATTTTTCAGCCGATG
GAAAATGTCTGGTGTCGGTTGGTTTAGACGATTTTCACAGTATTGTATTTTGGGACTGGAAAAAGGGAGAAAAGATAGCCACAACAAGAG
GACATAAAGATAAGATATTTGTGGTAAAGTGTAACCCACACCATGTTGACAAACTGGTTACAGTTGGGATAAAACACATCAAATTCTGGC
AACAAGCAGGTGGGGGCTTCACTTCTAAAAGAGGAACTTTTGGAAGCGTTGGAAAATTGGAAACAATGATGTGTGTTTCTTACGGACGAA
TGGAAGATCTAGTGTTCTCAGGAGCAGCTACTGGAGATATTTTTATTTGGAAAGACATTCTACTACTGAAGACAGTGAAAGCTCATGATG
GGCCTGTGTTTGCTATGTATGCACTGGATAAGGGCTTTGTAACAGGTGGAAAGGACGGCATCGTGGAGCTCTGGGATGATATGTTTGAAA
GATGTTTGAAGACTTATGCCATTAAAAGATCAGCATTGTCGACTAGCTCAAAAGGCTTGCTTTTGGAAGATAACCCTTCAATTCGTGCCA
TCACTTTGGGACATGGACATATCCTGGTGGGAACAAAAAATGGAGAGATTCTGGAAATTGATAAGAGTGGCCCAATGACACTGCTTGTTC
AGGGGCACATGGAAGGAGAAGTGTGGGGGTTGGCAGCTCACCCTCTCCTGCCCATCTGTGCAACAGTGAGCGATGATAAAACACTTCGCA
TCTGGGAACTATCTGCCCAGCACCGTATGCTGGCAGTACGGAAACTCAAAAAAGGTGGAAGATGCTGTGCCTTTTCCCCTGATGGGAAAG
CCTTAGCGGTTGGCTTGAACGATGGGAGTTTCCTGGTGGTAAATGCTGACACTGTTGAAGACATGGTCTCTTTCCATCACAGAAAAGAAA
TGATCTCTGATATTAAGTTTTCAAAAGATACGGGAAAATACCTTGCCGTGGCATCCCATGATAACTTTGTGGATATTTACAACGTACTTA
CAAGCAAAAGGGTTGGCATCTGTAAAGGTGCTTCTAGTTATATTACACACATTGACTGGGACTCTAGAGGAAAATTATTGCAAGTGAATT
CAGGTGCCAGAGAACAACTTTTTTTTGAAGCTCCAAGAGGCAAACGGCATATAATAAGACCTTCAGAGATCGAGAAGATAGAGTGGGACA
CATGGACCTGTGTCCTGGGGCCCACCTGTGAGGGAATCTGGCCAGCACATAGCGATATAACTGACGTAAATGCTGCCAGTCTTACCAAAG
ACTGTTCCCTTTTAGCCACCGGAGATGATTTTGGTTTCGTTAAGCTTTTTTCATATCCTGTCAAGGGACAGCACGCAAGATTCAAGAAGT
ATGTGGGGCACAGTGCACATGTCACTAACGTGAGGTGGCTGCACAATGACTCTGTGCTGCTCACGGTGGGCGGCGCCGACACAGCCCTGA
TGATCTGGACCAGGGAGTTTGTGGGGACCCAGGAGAGCAAGCTGGTGGACAGCGAGGAGTCAGACACCGACGTGGAAGAGGATGGAGGCT
ATGACAGCGATGTTGCTAGAGAAAAGGCCATTGACTACACCACCAAGATTTATGCTGTGAGCATCAGGGAAATGGAAGGCACCAAGCCAC
ACCAGCAGCTGAAGGAAGTTTCCGTGGAAGAAAGACCACCCGTTAGCCGAGCAGCTCCCCAGCCTGAGAAACTGCAGAAGAACAATATCA
CCAAAAAAAAGAAACTGGTTGAGGAGCTGGCTCTAGACCACGTGTTTGGCTACAGAGGTTTCGACTGTCGAAATAACCTGCATTACCTTA
ATGATGGCGCTGACATCATCTTCCACACAGCAGCGGCTGGCATCGTTCAGAACCTCTCCACAGGGAGCCAGAGCTTCTATCTGGAGCACA
CAGATGACATCCTCTGTCTCACAGTGAACCAGCACCCCAAGTACAGAAACGTGGTGGCCACCAGCCAGATAGGGACAACACCTTCCATCC
ACATATGGGACGCCATGACCAAACACACCCTCTCCATGCTGCGGTGCTTCCACTCCAAGGGGGTGAATTACATCAACTTCAGTGCAACTG
GAAAGCTCCTGGTGTCGGTGGGAGTGGACCCTGAGCACACCATCACTGTCTGGCGATGGCAGGAAGGTGCCAAGGTTGCCAGCCGAGGGG
GTCACCTGGAGCGCATATTTGTGGTGGAATTTCGCCCCGACTCAGACACGCAGTTTGTATCTGTCGGGGTCAAACATATGAAGTTCTGGA
CCCTGGCAGGCAGCGCCTTGCTTTACAAGAAAGGGGTCATCGGGTCCCTGGGAGCTGCCAAAATGCAGACGATGCTCTCCGTGGCCTTCG
GTGCTAACAATCTCACTTTCACGGGTGCCATCAATGGAGATGTCTACGTCTGGAAGGACCACTTCCTCATCCGGCTGGTGGCCAAGGCTC
ACACAGGCCCCGTGTTCACAATGTACACAACCCTTCGGGATGGACTCATAGTGACCGGCGGAAAAGAGAGGCCGACCAAAGAAGGAGGTG
CTGTAAAATTGTGGGACCAGGAGATGAAGCGCTGCCGGGCCTTTCAGCTGGAGACCGGGCAGCTGGTGGAGTGTGTGCGCTCCGTGTGCC
GTGGAAAAGGAAAAATCTTAGTGGGAACCAAAGACGGAGAAATAATTGAAGTTGGTGAAAAAAATGCTGCTTCTAACATCCTGATTGATG
GTCACATGGAAGGGGAGATCTGGGGCCTGGCCACTCACCCTTCCAAGGACCTCTTCATCTCTGCCAGCAACGATGGCACAGCCCGGATCT
GGGACCTGGCTGACAAGAAGCTGTTAAACAAGGTGAGCTTGGGCCATGCGGCCAGGTGTGCAGCCTACAGCCCTGATGGGGAGATGGTGG
CCATTGGCATGAAGAATGGAGAGTTTGTCATCTTGTTGGTGAACAGCCTGAAAGTTTGGGGGAAAAAACGAGACCGGAAATCTGCTATCC
AAGATATCAGAATCAGCCCAGACAACCGATTCTTAGCCGTTGGTTCTTCTGAACACACAGTTGACTTCTATGACCTCACTCAGGGCACAA
ATCTGAACCGCATTGGCTACTGCAAAGATATCCCAAGCTTTGTCATTCAGATGGATTTTTCTGCGGATGGCAAATACATTCAGGTGTCAA
CAGGTGCCTATAAGCGCCAGGTGCATGAGGTCCCCCTGGGGAAGCAGGTAACTGAAGCCGTGGTCATTGAGAAGATCACCTGGGCCTCCT
GGACAAGCGTCCTGGGAGATGAAGTCATTGGAATCTGGCCACGAAATGCAGACAAGGCTGATGTCAACTGCGCATGTGTGACCCACGCTG
GCCTGAACATTGTCACAGGAGATGACTTTGGGCTGGTGAAGCTCTTTGATTTTCCATGCACAGAAAAATTTGCCAAACATAAGCGATACT
TCGGTCACTCGGCTCACGTGACGAACATCCGTTTCTCTTATGATGACAAGTATGTGGTCAGCACTGGAGGAGACGACTGCAGTGTATTTG
TGTGGCGATGTCTGTAAAATGCCAGAAGCCTCTTATGTTATTGCTGCTGCTGCTACCAGCCAGCAACTGCAGAGGCCATGCTGAGGTGCC
TCCTTGCCACCAGCCGTTGGGAAATGCCTACCATGCTGCCCCGGATGCACAAGCTCAAAACGCTGCAGAAGTTACACAACTGCTCCCATA
ATCTGGACTCTCCAAAACCGTGATGCCACGAAGGAAGGTCAAGTTTTAAAATGTTAAAGACTGCTTGCCTCTGTTCCTGAGACTAAACAG
TATACATACTAACTACATTGACAAAGAAATCCTATCTGATAATGTAGCCCGCTGACGAATTTTGAAGCCTCGGTTACCCTAACCAATATG
TAGCTTTTAATTTGCATCAAAACTTTTACAAAGATGTTTTGCTATTGTTTCTATATACTTCAAGAATGTTCATTTTTACAAATAAGTTGA
ACAAGACAGCCTAAGTTAGATGCACCGAAGTACTAGAAATATCGCTAGCCTCTGTTCTCCAGTTTAGCTTTCAAAACCAAATGAGCCATG
TATAAAGGAGTTGAGAAACTTAATTTTTAAATGTTTCATTTGCAGAGTTTTATATCCATTAAGTGCCTTTGAAAGTTTCCAGTTGTGTGG
GCTGCTGTCTCACCTCCCACCAATTTCTCCTTTCTCCATATGGTGCTAAAACCTCAAAGCTGAGGAGGGCTGCAGGACCCTTAGCAGATT
CAGTGTGTCACCCTTGTCCTGTGTTCACGCCAAGGCTTCCTAAATGAAAGACATCGGTTACCTGCTTATGGGAAGGTGAGCAGCAAAGGA
ATTGAAGTTCGGGACAGGGTAGAATTATGGGTTTTCATTGTGTTTCATGCCAAACCCACAAAATCCAAAATAGAATTCAAGTTAAACAAA
CTTCTACTACAAAATGGAAGGGGAAAAAGGCTCAGGAAGGTCTATGAGAATGAGCTGACTTATCTCGTTAAATCTTAAGATAAATGAGGG
TAACCCAAGGCTGCACCTTGGTGTACCACCCTGAGTGGAGTTGAGGTGACTTCATTTGATTGCTTCAGGCGAACTATATAGGTCAAGTCC
AGATTATAAAAAAATTATCTGCAGAACAAATTGTAAACCCAAGGAATAGCTGGTAAATCAAAATTATAAAGTGAGTTAGAGTTCCTTGGA
GTTGGTTGTATGACGGAATATGACTTGGACAATCTTTACCAGAAGCCATCCGTAAGCCCCTCAGTCACACTTTCCATGTAGCTGACCAGT
GACTACAGGATGTGGCTGACAGTGCTCACTGAAAGGAGAGTTGGTGCGGGACTGGTGGTTCTGAGCACATAGACGCCTATTAGTCCTTCT
GGTCAGTGAACGAAAATTCTAGACCTACAGTTACTGGCTACTTGCATTTGTCAGTTTAGAGAAAAGGTAAAATGAGGCATTTTCAATTGT
AGAATAGACTAACATTTACCACAGAAGTGCTTCAGCATTCTAAATGGATTAGATCACTCATTAAGCTATTTTTATATGCCAATTTACTAA
TGCCTTACATCAATCCACTAATAGGTTGTTGGGCCCGCAGTAGAGTCCCTATGCAGTCCCAATTCTGTTTTCTGTAACCATGTGACTGGT
GATGCAGAGTGATAACCATGTCTGCCTATCTTGTACTAGACTCTTCATGCTGATCGGATCTTGCATTGAAATAACCATGTGGAAGAACAA
TGAATCGATTAATGATGACATGTACAACCATATTTAAAGAGCAATAGTGTCCGTGTGTCATGAAAAACTTATTTGTAAACGTTTATATGG
TATGATTTTGATTTTATGTATGTTCATAAATCCTGCACTGTATGATATATGTGAGTTAAAACATTGGTGCATGAATTTATTTTCAAAGTA

>9757_9757_1_BIRC6-EML6_BIRC6_chr2_32679010_ENST00000421745_EML6_chr2_55071184_ENST00000356458_length(amino acids)=3260AA_BP=1849
MVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSAAGAGAAGVSEWLVLRDGCMHCDADGLHSLSYHPALNAILAVTSRGT
IKVIDGTSGATLQASALSAKPGGQVKCQYISAVDKVIFVDDYAVGCRKDLNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACLEK
VDISSTEGYDLFITQLKDGLKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELKKINQNVAALPVASSVMDRLSYLLPSARPEL
GVGPGRSVDRSLMYSEANRRETFTSWPHVGYRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVKG
EHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFLAAATKRGKICIWDVSKLMKVHLKFEINAYDPAIVQQLILSGDPSSGVDSR
RPTLAWLEDSSSCSDIPKLEGDSDDLLEDSDSEEHSRSDSVTGHTSQKEAMEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGA
NPCLTNSKSEKTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGESISEQGSTDNESCTNSELNSPLVRRTLPVL
LLYSIKESDEKAGKIFSQMNNIMSKSLHDDGFTVPQIIEMELDSQEQLLLQDPPVTYIQQFADAAANLTSPDSEKWNSVFPKPGTLVQCL
RLPKFAEEENLCIDSITPCADGIHLLVGLRTCPVESLSAINQVEALNNLNKLNSALCNRRKGELESNLAVVNGANISVIQHESPADVQTP
LIIQPEQRNVSGGYLVLYKMNYATRIVTLEEEPIKIQHIKDPQDTITSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTL
GHLVITTQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKGGELHFLQIGGTCDDIDEADILVDGSLSKGIEP
SSEGSKPLSNPSSPGISGVDLLVDQPFTLEILTSLVELTRFETLTPRFSATVPPCWVEVQQEQQQRRHPQHLHQQHHGDAAQHTRTWKLQ
TDSNSWDEHVFELVLPKACMVGHVDFKFVLNSNITNIPQIQVTLLKNKAPGLGKVNALNIEVEQNGKPSLVDLNEEMQHMDVEESQCLRL
CPFLEDHKEDILCGPVWLASGLDLSGHAGMLTLTSPKLVKGMAGGKYRSFLIHVKAVNERGTEEICNGGMRPVVRLPSLKHQSNKGYSLA
SLLAKVAAGKEKSSNVKNENTSGTRKSENLRGCDLLQEVSVTIRRFKKTSISKERVQRCAMLQFSEFHEKLVNTLCRKTDDGQITEHAQS
LVLDTLCWLAGVHSNGPGSSKEGNENLLSKTRKFLSDIVRVCFFEAGRSIAHKCARFLALCISNGKCDPCQPAFGPVLLKALLDNMSFLP
AATTGGSVYWYFVLLNYVKDEDLAGCSTACASLLTAVSRQLQDRLTPMEALLQTRYGLYSSPFDPVLFDLEMSGSSCKNVYNSSIGVQSD
EIDLSDVLSGNGKVSSCTAAEGSFTSLTGLLEVEPLHFTCVSTSDGTRIERDDASLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPML
ILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRK
EVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRMPSGKPLTSKEEIKGIPWA
SWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSV
FQWRFIPEGVSNGMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEKNHAVPFLKREKAPEDSLK
LQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLK
GQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAGGGFTSKRGTFG
SVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVKAHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALST
SSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRK
LKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYI
THIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDFGFVK
LFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGADTALMIWTREFVGTQESKLVDSEESDTDVEEDGGYDSDVAREKAIDYTT
KIYAVSIREMEGTKPHQQLKEVSVEERPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGI
VQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTI
TVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDV
YVWKDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEI
IEVGEKNAASNILIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEFVILLVN
SLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGK
QVTEAVVIEKITWASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSYD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BIRC6-EML6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BIRC6-EML6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BIRC6-EML6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource