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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP54-DNAJB12 (FusionGDB2 ID:97577)

Fusion Gene Summary for USP54-DNAJB12

check button Fusion gene summary
Fusion gene informationFusion gene name: USP54-DNAJB12
Fusion gene ID: 97577
HgeneTgene
Gene symbol

USP54

DNAJB12

Gene ID

159195

54788

Gene nameubiquitin specific peptidase 54DnaJ heat shock protein family (Hsp40) member B12
SynonymsC10orf29|bA137L10.3|bA137L10.4DJ10
Cytomap

10q22.2

10q22.1

Type of geneprotein-codingprotein-coding
Descriptioninactive ubiquitin carboxyl-terminal hydrolase 54inactive ubiquitin-specific peptidase 54ubiquitin specific protease 54ubiquitin specific proteinase 54dnaJ homolog subfamily B member 12DnaJ (Hsp40) homolog, subfamily B, member 12
Modification date2020031320200313
UniProtAcc.

Q9NXW2

Ensembl transtripts involved in fusion geneENST00000319786, ENST00000339859, 
ENST00000408019, ENST00000428547, 
ENST00000394811, ENST00000422491, 
ENST00000497106, 		ENST00000461919, 
ENST00000338820, ENST00000394903, 
ENST00000444643, 
Fusion gene scores* DoF score19 X 13 X 9=22237 X 5 X 6=210
# samples 208
** MAII scorelog2(20/2223*10)=-3.47443604325227
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP54 [Title/Abstract] AND DNAJB12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP54(75331179)-DNAJB12(74104885), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDNAJB12

GO:0034622

cellular protein-containing complex assembly

27916661

TgeneDNAJB12

GO:0036503

ERAD pathway

21148293|21150129

TgeneDNAJB12

GO:0051085

chaperone cofactor-dependent protein refolding

27916661

TgeneDNAJB12

GO:0071218

cellular response to misfolded protein

21148293|21150129


check buttonFusion gene breakpoints across USP54 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNAJB12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-CI-6624-01CUSP54chr10

75331179

-DNAJB12chr10

74104885

-


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Fusion Gene ORF analysis for USP54-DNAJB12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000319786ENST00000461919USP54chr10

75331179

-DNAJB12chr10

74104885

-
5CDS-intronENST00000339859ENST00000461919USP54chr10

75331179

-DNAJB12chr10

74104885

-
5CDS-intronENST00000408019ENST00000461919USP54chr10

75331179

-DNAJB12chr10

74104885

-
5CDS-intronENST00000428547ENST00000461919USP54chr10

75331179

-DNAJB12chr10

74104885

-
5UTR-3CDSENST00000394811ENST00000338820USP54chr10

75331179

-DNAJB12chr10

74104885

-
5UTR-3CDSENST00000394811ENST00000394903USP54chr10

75331179

-DNAJB12chr10

74104885

-
5UTR-3CDSENST00000394811ENST00000444643USP54chr10

75331179

-DNAJB12chr10

74104885

-
5UTR-intronENST00000394811ENST00000461919USP54chr10

75331179

-DNAJB12chr10

74104885

-
Frame-shiftENST00000319786ENST00000394903USP54chr10

75331179

-DNAJB12chr10

74104885

-
Frame-shiftENST00000319786ENST00000444643USP54chr10

75331179

-DNAJB12chr10

74104885

-
Frame-shiftENST00000339859ENST00000338820USP54chr10

75331179

-DNAJB12chr10

74104885

-
Frame-shiftENST00000339859ENST00000394903USP54chr10

75331179

-DNAJB12chr10

74104885

-
Frame-shiftENST00000339859ENST00000444643USP54chr10

75331179

-DNAJB12chr10

74104885

-
Frame-shiftENST00000408019ENST00000338820USP54chr10

75331179

-DNAJB12chr10

74104885

-
Frame-shiftENST00000428547ENST00000338820USP54chr10

75331179

-DNAJB12chr10

74104885

-
In-frameENST00000319786ENST00000338820USP54chr10

75331179

-DNAJB12chr10

74104885

-
In-frameENST00000408019ENST00000394903USP54chr10

75331179

-DNAJB12chr10

74104885

-
In-frameENST00000408019ENST00000444643USP54chr10

75331179

-DNAJB12chr10

74104885

-
In-frameENST00000428547ENST00000394903USP54chr10

75331179

-DNAJB12chr10

74104885

-
In-frameENST00000428547ENST00000444643USP54chr10

75331179

-DNAJB12chr10

74104885

-
intron-3CDSENST00000422491ENST00000338820USP54chr10

75331179

-DNAJB12chr10

74104885

-
intron-3CDSENST00000422491ENST00000394903USP54chr10

75331179

-DNAJB12chr10

74104885

-
intron-3CDSENST00000422491ENST00000444643USP54chr10

75331179

-DNAJB12chr10

74104885

-
intron-3CDSENST00000497106ENST00000338820USP54chr10

75331179

-DNAJB12chr10

74104885

-
intron-3CDSENST00000497106ENST00000394903USP54chr10

75331179

-DNAJB12chr10

74104885

-
intron-3CDSENST00000497106ENST00000444643USP54chr10

75331179

-DNAJB12chr10

74104885

-
intron-intronENST00000422491ENST00000461919USP54chr10

75331179

-DNAJB12chr10

74104885

-
intron-intronENST00000497106ENST00000461919USP54chr10

75331179

-DNAJB12chr10

74104885

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000408019USP54chr1075331179-ENST00000394903DNAJB12chr1074104885-30702572351251338
ENST00000408019USP54chr1075331179-ENST00000444643DNAJB12chr1074104885-30692572351251338
ENST00000428547USP54chr1075331179-ENST00000394903DNAJB12chr1074104885-30702572351251338
ENST00000428547USP54chr1075331179-ENST00000444643DNAJB12chr1074104885-30692572351251338
ENST00000319786USP54chr1075331179-ENST00000338820DNAJB12chr1074104885-5059108410622078338

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000408019ENST00000394903USP54chr1075331179-DNAJB12chr1074104885-0.00927040.99072963
ENST00000408019ENST00000444643USP54chr1075331179-DNAJB12chr1074104885-0.0084129820.99158704
ENST00000428547ENST00000394903USP54chr1075331179-DNAJB12chr1074104885-0.00927040.99072963
ENST00000428547ENST00000444643USP54chr1075331179-DNAJB12chr1074104885-0.0084129820.99158704
ENST00000319786ENST00000338820USP54chr1075331179-DNAJB12chr1074104885-0.0131038160.9868962

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Fusion Genomic Features for USP54-DNAJB12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP54-DNAJB12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:75331179/chr10:74104885)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DNAJB12

Q9NXW2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21150129, PubMed:21148293). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDNAJB12chr10:75331179chr10:74104885ENST0000044464309112_17644807.6666666666666DomainJ
TgeneDNAJB12chr10:75331179chr10:74104885ENST0000044464309265_37544807.6666666666666Topological domainLumenal
TgeneDNAJB12chr10:75331179chr10:74104885ENST0000044464309244_26444807.6666666666666TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP54chr10:75331179chr10:74104885ENST00000339859-323736_770801685.0Coiled coilOntology_term=ECO:0000255
HgeneUSP54chr10:75331179chr10:74104885ENST00000394811-221736_7700726.0Coiled coilOntology_term=ECO:0000255
HgeneUSP54chr10:75331179chr10:74104885ENST00000408019-222736_770801685.0Coiled coilOntology_term=ECO:0000255
HgeneUSP54chr10:75331179chr10:74104885ENST00000428547-218736_770801535.0Coiled coilOntology_term=ECO:0000255
HgeneUSP54chr10:75331179chr10:74104885ENST00000339859-323559_570801685.0Compositional biasNote=Poly-Ser
HgeneUSP54chr10:75331179chr10:74104885ENST00000339859-323866_869801685.0Compositional biasNote=Poly-Gln
HgeneUSP54chr10:75331179chr10:74104885ENST00000394811-221559_5700726.0Compositional biasNote=Poly-Ser
HgeneUSP54chr10:75331179chr10:74104885ENST00000394811-221866_8690726.0Compositional biasNote=Poly-Gln
HgeneUSP54chr10:75331179chr10:74104885ENST00000408019-222559_570801685.0Compositional biasNote=Poly-Ser
HgeneUSP54chr10:75331179chr10:74104885ENST00000408019-222866_869801685.0Compositional biasNote=Poly-Gln
HgeneUSP54chr10:75331179chr10:74104885ENST00000428547-218559_570801535.0Compositional biasNote=Poly-Ser
HgeneUSP54chr10:75331179chr10:74104885ENST00000428547-218866_869801535.0Compositional biasNote=Poly-Gln
HgeneUSP54chr10:75331179chr10:74104885ENST00000339859-32331_352801685.0DomainNote=USP
HgeneUSP54chr10:75331179chr10:74104885ENST00000394811-22131_3520726.0DomainNote=USP
HgeneUSP54chr10:75331179chr10:74104885ENST00000408019-22231_352801685.0DomainNote=USP
HgeneUSP54chr10:75331179chr10:74104885ENST00000428547-21831_352801535.0DomainNote=USP
TgeneDNAJB12chr10:75331179chr10:74104885ENST00000444643091_24344807.6666666666666Topological domainCytoplasmic


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Fusion Gene Sequence for USP54-DNAJB12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97577_97577_1_USP54-DNAJB12_USP54_chr10_75331179_ENST00000319786_DNAJB12_chr10_74104885_ENST00000338820_length(transcript)=5059nt_BP=1084nt
AACTTTGTCATGAATTGTCAGTGCTGAGTTCCTGGTAGTTGGTAAAAAGAATTGCCTTCTCTCTGATATCCTGTTCTGCGGGAAGTCCTT
GTGGTTTAGATTCACAGTTTCTCATTGTTGCTAGCTACAGTCGTCTCCTCCCTCCTAGCCTTCCCTCCCCACAGCTCTAGCTATTCCCAT
ATCCCTCCCCATTCTTGTATCACTTGCCCCACAGATACCCTCGTGATTAGAGGTCTTTTGCTGGAGGTTGACTGTGCTGTCTGCTCTCTG
ACACAGCTGGCTATTCTAGTCCCAGAAGAAAGAGGAGAGACTTGCTGAAGATCTGGATGGGACAATAGAAGTTTGGGGCACATTAAAAAG
AAGCAGCAAGAACATCAACAAAAACCTCAGATGATTCAAACAGGCTTCTTCTTGGCTTTGTGGAACCTTTTGCAGTTGCTCAGAATTTGA
GTTTTTGCTTCAGAGGATGATGAGACAAGGCAATAGAGGGTGAGGAGGATCATGTTGGATTCTTGCTTCTCTGTCTGCCTCTCCTTCCAG
TTGGAAAAATCTTCAGTCCATAAGAAGCATTATCAACAAGCCTGAAGAACACATCTTACCCTGATCCTGGATGCTGTTGGAGTTGAGAAT
TACATCCACTTCACCAGGACTTTATGGAGGCTGTTCAAGAAAAATAGAAGGAAGCAATACTTAAGGATTTCTCTGTTTGCATTAGTCCTG
TGCCATGTTACATTTTGGAGATTGTTTGGAACAAGTGAGGGAGGGCTCTGTCATCTTGATCTAGGAGGATACCTGAGTCCCTTGACTACA
CAGATGATATTTGGAAGGCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTT
TGCACCTCGAAGCTCAACCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCA
GGTTTTGTGGCACTTGGATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCT
CAAGCCCTGATTGAGTCCCTCAACCAGAAACCACAGACTGCCGGTGACCAACCCCCACCCACAGACACAACCCATGCCACCCACAGGAAA
GCAGGTGGGACCGATGCCCCCTCGGCCAACGGTGAAGCTGGAGGAGAGAGCACCAAAGGCTACACTGCAGAACAGGTTGCAGCTGTGAAA
AGGGTCAAGCAATGTAAAGATTACTATGAGATCCTGGGGGTGAGCAGAGGGGCCTCGGATGAGGACCTGAAGAAGGCCTACCGCAGACTG
GCCCTCAAATTCCACCCAGACAAGAACCACGCACCTGGTGCCACTGAAGCCTTCAAAGCCATTGGCACAGCATATGCGGTACTCAGCAAC
CCGGAGAAGAGGAAGCAGTATGACCAGTTCGGCGATGACAAGAGCCAGGCGGCCCGGCACGGCCATGGGCATGGGGATTTCCACCGTGGC
TTTGAGGCCGACATCTCCCCTGAAGACCTCTTCAACATGTTCTTTGGCGGCGGCTTCCCTTCTAGTAACGTCCACGTCTACAGCAACGGC
CGCATGCGCTATACCTACCAGCAAAGGCAGGACCGCAGGGACAACCAGGGTGATGGCGGGCTAGGGGTGTTTGTGCAGCTGATGCCTATC
CTCATCCTGATTCTCGTGTCAGCTCTCAGCCAGCTCATGGTCTCCAGTCCACCCTACAGTCTGAGTCCAAGACCGTCCGTGGGCCACATC
CACAGGCGAGTCACTGACCACCTGGGTGTCGTCTACTATGTGGGAGACACTTTCTCCGAAGAGTACACAGGCTCCAGCCTCAAAACAGTC
GAGCGGAATGTGGAAGATGATTATATCGCCAACCTCCGGAACAACTGCTGGAAGGAGAAGCAGCAGAAGGAAGGCTTGCTGTACCGGGCA
CGCTACTTTGGCGACACAGATATGTACCACAGAGCACAGAAGATGGGCACCCCCAGCTGCAGCCGACTGTCAGAGGTGCAGGCCTCCCTG
CATGGATAGTCCTGGGCCAGCCACACCACCGAGGTCCAAGTATGAGCCAGGGCTGCCTCCACCCTGCAACTCCTGGCAGCTTTGGCCCTG
GTCATGAGCAGAGGAGGGAGGGGGAGAAAGGGAGGAAGCCTGGTGATTGTGGCAAAGACTCCTGTCCCCAGCCTGACCTCCAGCCTCCAG
AGACCGAGCAGCTGTGGGGCCTGCTGGGAAACCAAGGTCGGTTTCCGCCCTCTAGCGATGCTGTCCTCCCCACTCCTCCGCTCTGCTCCC
TGGCTCCAGGGGTGTGGGGGACCCCAGAACCAGGCAGAGTGGGAACTTGAAACTGTTGCTGAGGGCCACCCGGGGCTTCTTGGTCCACTC
CAGCCATCAGTCAGCACGGCCCTTTCTCCAGCACAGCAGACTATTGTCCGTGCCCTGGTATTTAGGCCATCACATATGGTGGGGCCCAAG
AGAGCCCCATATGCACACTGCCTGCCTGATACCAGGAAGAACCATGTGGGAATAGGTGGGCCAAGAGCCCTCCCCTTTCTCCATCCCTCC
AGCTAGGAGGAAATGGAGCAAGATGAACAGGCAGCCACGAGGTGGGTGGGAGCTGGCAGTCTTGGTGGCGGCAGGGGCCGCGGGCCCTGA
CCACCCCCCTCTGGTGGGATCTGAGGCACTCTCTCGAATGCCGTCACACCTGGCAGCCTGGAAGCCACAGGCATCCGGCCTTGCCCAGGC
ATCTCGCCTGCGGTCTGAGGAAGGGAACAGAAGGTCATGAGTTCAGGGTCAGACGCAGCCGCTCAGCACAGGAGGGGTGGAGGGGAAATG
AGAGTTGCTGGTAGCAGGCTCCCTCCTTCTGCAGCCCGGCGAATGGGGGCGCTGGGCTCTGTTCCCAGCGTTTGCCAGAGGTGGCCACTT
CAGCCAAGCCCAGAGAAGTGTGGGCAGAAGCAGTGAAGGTTCTTCTCTGTGTGGGTGCCCTGCCCACCCCCTCCTTTGCCTGTGTCCTCC
CGGCCTGGATCCATGGCTGACTCTGCCTGGAGGCCATTTGTGCCTGCCTCTGTGCTGCCGCAGGAGGGCAGGCCGCAAGTGGGGTTGGTG
GGGGTCGAGCGGGCAGCACGGTGCAGCGGTGCAGTGGCAAGGGGGGCTACTTGTGTGGCATAAGCTAGAGGAGCCGGTGCCGCCTGAATG
CCGAGCTAACTGTTGCCACTCTCCTCCCCAGACTATGAAATCCCTGGAGAATTTTTGGTGACATGCACTGAGCCAAGGTGATGGACTGTA
TATTTGAGGAAAGACAAACAAAGAAACAAAATTAAAATGGAATTGGAGGCCGAACGCTGCACAGCTGCCCTCTCTCTCACCCAGTAAATG
CAGAAAGCTCTTAGGACAGACAGAAAACCTGCCATGGGGCTGCTTCCCTCCCTCGCAGGGCTGGCGGAGGCTCCGCATCGCCTCTCTCCT
AGGATACAGAAACCATGGCAACGAAAGTAGAATGTAAAACTCGCAGCAGATATCAGTGGGAAGGGCTGGGGGAGGGGGCACCCAGCTGCC
TTTCCTCCCTCACAGGAGCCACCACCAGCCACCTCTCAGGAGAAGCCAGAGGCCCTGGCCAAAGATAGGAGGAAGAAAGAGAACTCTCCA
TAGAATGTAATTTATAGATGCGTGTATATGTATATATATCTATTTATATGTAAATAGGCATATATGAAGATATATATATATATAGTCTAC
TTTTTAAACTCTGCAGGGATTTGGTTAAGTTGTTGAGCTGATTTCTTCCATGTTTTAGAAAATGAGGCCTGTTTGGGGAAGGTACCCTGG
TGATGTTTTTGCTAGACATTAGCTGTAGCTGACAGCATAAGGAGAGTCGCATCAGAGCTTTTCACAGCCCCCCGAAACCCCAGCCTGGTT
TTGATGGCAGCAGTAATCATGATAGTGTGAACCCGCGAAGGCCTCAGGATTATGGTTAACCTGGAGAGGAGCAGGCCATGGAGGCAGGTG
CCAGGTCAGTATTGAGTCACAGTAGAGGCCCCACAAGGACCTGCTTGGGTGAGACCACCTCTCCCCTCTCAGCAGCGCTGGTGGGCTCTT
TGTCCTGGTGCCCAGGAGCCCTCCAGCCCCCTGCCCACAGAAGGGAAGGCCTGCAGAGGGGGCCAGGATCTACCTAACCATTTCCCCACC
CCTAAGTCCCTCAGTGGGCTTTGCCTTATAGGTGCCACAGGGCACAGCTCCATCATTGCCACTGGTTTTTCCTAAGTCATGCACCAAGGA
CTTCAGAAAGTTCTTCCTCCGAGTCAGTCAGTGGTGCCGGGACCCCAGGGCAGCCTCCTCGACTCCTGAAGAAAAGGCAGTGCCCGTGGC
TGCCTCTGTCTTCACTCGCTGTTGATGTGACCGCCAGGCCTCCTCTCGTACCTTGGACAAAGGATACACCTGAACCAGAATAGTTTTCTT
ACCCTCACATTGAAATGAGGATTTTGCTTAAAACAGCACTTGCCGCCAGTGGGAGGAGGGAGGTTTTATTTATTCCCACAGTTTCTCCTG
GGCCTTCTGGAATGACCATGTTTTCCTGTGGCGGTGGGTGTGTCATTGCGCCCGCCGTCTTCCAAAGCCTTACTTCCCCAAGCTGCCAGC
CAGGAGGTGATAACCACCCTCCCAGAGTTTCTCTCGGCTCTTTTTTTAAAAGTCCCCCAACAAATAGGATTCTTGCTGGGAAAGGAAGTT
CGGTAAGGAAATGTCAAATCTGGTTTTTAAACAAGGTCCAACCCTGCAATGAAGCAGCCACTTCAGCCCAGAGAGATTATAAGAACTGAT
GTGGCCAGAGTGCCTACCCACTGTGGCCCCGGTGCTCTGCCCCCACGCCCCGACCATCTGGTCTTGGTAGATGTCCCTAGACGGGCTGAG
CCATGTGCAATAAGAACATAGATCCTAAAGGATCCTCTGGAAGCTGTATTTCTTGAATTAGAATTCTCAAATTGTACATCTGTTAATATA

>97577_97577_1_USP54-DNAJB12_USP54_chr10_75331179_ENST00000319786_DNAJB12_chr10_74104885_ENST00000338820_length(amino acids)=338AA_BP=7
MHLLRSQALIESLNQKPQTAGDQPPPTDTTHATHRKAGGTDAPSANGEAGGESTKGYTAEQVAAVKRVKQCKDYYEILGVSRGASDEDLK
KAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKSQAARHGHGHGDFHRGFEADISPEDLFNMFFGGGFPSSNV
HVYSNGRMRYTYQQRQDRRDNQGDGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSPRPSVGHIHRRVTDHLGVVYYVGDTFSEEYTG

--------------------------------------------------------------
>97577_97577_2_USP54-DNAJB12_USP54_chr10_75331179_ENST00000408019_DNAJB12_chr10_74104885_ENST00000394903_length(transcript)=3070nt_BP=257nt
GCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAA
CCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGG
ATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGCCCTGATTGAGTC
CCTCAACCAGAAACCACAGACTGCCGGTGACCAACCCCCACCCACAGACACAACCCATGCCACCCACAGGAAAGCAGGTGGGACCGATGC
CCCCTCGGCCAACGGTGAAGCTGGAGGAGAGAGCACCAAAGGCTACACTGCAGAACAGGTTGCAGCTGTGAAAAGGGTCAAGCAATGTAA
AGATTACTATGAGATCCTGGGGGTGAGCAGAGGGGCCTCGGATGAGGACCTGAAGAAGGCCTACCGCAGACTGGCCCTCAAATTCCACCC
AGACAAGAACCACGCACCTGGTGCCACTGAAGCCTTCAAAGCCATTGGCACAGCATATGCGGTACTCAGCAACCCGGAGAAGAGGAAGCA
GTATGACCAGTTCGGCGATGACAAGAGCCAGGCGGCCCGGCACGGCCATGGGCATGGGGATTTCCACCGTGGCTTTGAGGCCGACATCTC
CCCTGAAGACCTCTTCAACATGTTCTTTGGCGGCGGCTTCCCTTCTAGTAACGTCCACGTCTACAGCAACGGCCGCATGCGCTATACCTA
CCAGCAAAGGCAGGACCGCAGGGACAACCAGGGTGATGGCGGGCTAGGGGTGTTTGTGCAGCTGATGCCTATCCTCATCCTGATTCTCGT
GTCAGCTCTCAGCCAGCTCATGGTCTCCAGTCCACCCTACAGTCTGAGTCCAAGACCGTCCGTGGGCCACATCCACAGGCGAGTCACTGA
CCACCTGGGTGTCGTCTACTATGTGGGAGACACTTTCTCCGAAGAGTACACAGGCTCCAGCCTCAAAACAGTCGAGCGGAATGTGGAAGA
TGATTATATCGCCAACCTCCGGAACAACTGCTGGAAGGAGAAGCAGCAGAAGGAAGGCTTGCTGTACCGGGCACGCTACTTTGGCGACAC
AGATATGTACCACAGAGCACAGAAGATGGGCACCCCCAGCTGCAGCCGACTGTCAGAGGTGCAGGCCTCCCTGCATGGATAGTCCTGGGC
CAGCCACACCACCGAGGTCCAAACTATGAAATCCCTGGAGAATTTTTGGTGACATGCACTGAGCCAAGGTGATGGACTGTATATTTGAGG
AAAGACAAACAAAGAAACAAAATTAAAATGGAATTGGAGGCCGAACGCTGCACAGCTGCCCTCTCTCTCACCCAGTAAATGCAGAAAGCT
CTTAGGACAGACAGAAAACCTGCCATGGGGCTGCTTCCCTCCCTCGCAGGGCTGGCGGAGGCTCCGCATCGCCTCTCTCCTAGGATACAG
AAACCATGGCAACGAAAGTAGAATGTAAAACTCGCAGCAGATATCAGTGGGAAGGGCTGGGGGAGGGGGCACCCAGCTGCCTTTCCTCCC
TCACAGGAGCCACCACCAGCCACCTCTCAGGAGAAGCCAGAGGCCCTGGCCAAAGATAGGAGGAAGAAAGAGAACTCTCCATAGAATGTA
ATTTATAGATGCGTGTATATGTATATATATCTATTTATATGTAAATAGGCATATATGAAGATATATATATATATAGTCTACTTTTTAAAC
TCTGCAGGGATTTGGTTAAGTTGTTGAGCTGATTTCTTCCATGTTTTAGAAAATGAGGCCTGTTTGGGGAAGGTACCCTGGTGATGTTTT
TGCTAGACATTAGCTGTAGCTGACAGCATAAGGAGAGTCGCATCAGAGCTTTTCACAGCCCCCCGAAACCCCAGCCTGGTTTTGATGGCA
GCAGTAATCATGATAGTGTGAACCCGCGAAGGCCTCAGGATTATGGTTAACCTGGAGAGGAGCAGGCCATGGAGGCAGGTGCCAGGTCAG
TATTGAGTCACAGTAGAGGCCCCACAAGGACCTGCTTGGGTGAGACCACCTCTCCCCTCTCAGCAGCGCTGGTGGGCTCTTTGTCCTGGT
GCCCAGGAGCCCTCCAGCCCCCTGCCCACAGAAGGGAAGGCCTGCAGAGGGGGCCAGGATCTACCTAACCATTTCCCCACCCCTAAGTCC
CTCAGTGGGCTTTGCCTTATAGGTGCCACAGGGCACAGCTCCATCATTGCCACTGGTTTTTCCTAAGTCATGCACCAAGGACTTCAGAAA
GTTCTTCCTCCGAGTCAGTCAGTGGTGCCGGGACCCCAGGGCAGCCTCCTCGACTCCTGAAGAAAAGGCAGTGCCCGTGGCTGCCTCTGT
CTTCACTCGCTGTTGATGTGACCGCCAGGCCTCCTCTCGTACCTTGGACAAAGGATACACCTGAACCAGAATAGTTTTCTTACCCTCACA
TTGAAATGAGGATTTTGCTTAAAACAGCACTTGCCGCCAGTGGGAGGAGGGAGGTTTTATTTATTCCCACAGTTTCTCCTGGGCCTTCTG
GAATGACCATGTTTTCCTGTGGCGGTGGGTGTGTCATTGCGCCCGCCGTCTTCCAAAGCCTTACTTCCCCAAGCTGCCAGCCAGGAGGTG
ATAACCACCCTCCCAGAGTTTCTCTCGGCTCTTTTTTTAAAAGTCCCCCAACAAATAGGATTCTTGCTGGGAAAGGAAGTTCGGTAAGGA
AATGTCAAATCTGGTTTTTAAACAAGGTCCAACCCTGCAATGAAGCAGCCACTTCAGCCCAGAGAGATTATAAGAACTGATGTGGCCAGA
GTGCCTACCCACTGTGGCCCCGGTGCTCTGCCCCCACGCCCCGACCATCTGGTCTTGGTAGATGTCCCTAGACGGGCTGAGCCATGTGCA
ATAAGAACATAGATCCTAAAGGATCCTCTGGAAGCTGTATTTCTTGAATTAGAATTCTCAAATTGTACATCTGTTAATATATGTTTATTA

>97577_97577_2_USP54-DNAJB12_USP54_chr10_75331179_ENST00000408019_DNAJB12_chr10_74104885_ENST00000394903_length(amino acids)=338AA_BP=7
MHLLRSQALIESLNQKPQTAGDQPPPTDTTHATHRKAGGTDAPSANGEAGGESTKGYTAEQVAAVKRVKQCKDYYEILGVSRGASDEDLK
KAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKSQAARHGHGHGDFHRGFEADISPEDLFNMFFGGGFPSSNV
HVYSNGRMRYTYQQRQDRRDNQGDGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSPRPSVGHIHRRVTDHLGVVYYVGDTFSEEYTG

--------------------------------------------------------------
>97577_97577_3_USP54-DNAJB12_USP54_chr10_75331179_ENST00000408019_DNAJB12_chr10_74104885_ENST00000444643_length(transcript)=3069nt_BP=257nt
GCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAA
CCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGG
ATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGCCCTGATTGAGTC
CCTCAACCAGAAACCACAGACTGCCGGTGACCAACCCCCACCCACAGACACAACCCATGCCACCCACAGGAAAGCAGGTGGGACCGATGC
CCCCTCGGCCAACGGTGAAGCTGGAGGAGAGAGCACCAAAGGCTACACTGCAGAACAGGTTGCAGCTGTGAAAAGGGTCAAGCAATGTAA
AGATTACTATGAGATCCTGGGGGTGAGCAGAGGGGCCTCGGATGAGGACCTGAAGAAGGCCTACCGCAGACTGGCCCTCAAATTCCACCC
AGACAAGAACCACGCACCTGGTGCCACTGAAGCCTTCAAAGCCATTGGCACAGCATATGCGGTACTCAGCAACCCGGAGAAGAGGAAGCA
GTATGACCAGTTCGGCGATGACAAGAGCCAGGCGGCCCGGCACGGCCATGGGCATGGGGATTTCCACCGTGGCTTTGAGGCCGACATCTC
CCCTGAAGACCTCTTCAACATGTTCTTTGGCGGCGGCTTCCCTTCTAGTAACGTCCACGTCTACAGCAACGGCCGCATGCGCTATACCTA
CCAGCAAAGGCAGGACCGCAGGGACAACCAGGGTGATGGCGGGCTAGGGGTGTTTGTGCAGCTGATGCCTATCCTCATCCTGATTCTCGT
GTCAGCTCTCAGCCAGCTCATGGTCTCCAGTCCACCCTACAGTCTGAGTCCAAGACCGTCCGTGGGCCACATCCACAGGCGAGTCACTGA
CCACCTGGGTGTCGTCTACTATGTGGGAGACACTTTCTCCGAAGAGTACACAGGCTCCAGCCTCAAAACAGTCGAGCGGAATGTGGAAGA
TGATTATATCGCCAACCTCCGGAACAACTGCTGGAAGGAGAAGCAGCAGAAGGAAGGCTTGCTGTACCGGGCACGCTACTTTGGCGACAC
AGATATGTACCACAGAGCACAGAAGATGGGCACCCCCAGCTGCAGCCGACTGTCAGAGGTGCAGGCCTCCCTGCATGGATAGTCCTGGGC
CAGCCACACCACCGAGGTCCAAACTATGAAATCCCTGGAGAATTTTTGGTGACATGCACTGAGCCAAGGTGATGGACTGTATATTTGAGG
AAAGACAAACAAAGAAACAAAATTAAAATGGAATTGGAGGCCGAACGCTGCACAGCTGCCCTCTCTCTCACCCAGTAAATGCAGAAAGCT
CTTAGGACAGACAGAAAACCTGCCATGGGGCTGCTTCCCTCCCTCGCAGGGCTGGCGGAGGCTCCGCATCGCCTCTCTCCTAGGATACAG
AAACCATGGCAACGAAAGTAGAATGTAAAACTCGCAGCAGATATCAGTGGGAAGGGCTGGGGGAGGGGGCACCCAGCTGCCTTTCCTCCC
TCACAGGAGCCACCACCAGCCACCTCTCAGGAGAAGCCAGAGGCCCTGGCCAAAGATAGGAGGAAGAAAGAGAACTCTCCATAGAATGTA
ATTTATAGATGCGTGTATATGTATATATATCTATTTATATGTAAATAGGCATATATGAAGATATATATATATATAGTCTACTTTTTAAAC
TCTGCAGGGATTTGGTTAAGTTGTTGAGCTGATTTCTTCCATGTTTTAGAAAATGAGGCCTGTTTGGGGAAGGTACCCTGGTGATGTTTT
TGCTAGACATTAGCTGTAGCTGACAGCATAAGGAGAGTCGCATCAGAGCTTTTCACAGCCCCCCGAAACCCCAGCCTGGTTTTGATGGCA
GCAGTAATCATGATAGTGTGAACCCGCGAAGGCCTCAGGATTATGGTTAACCTGGAGAGGAGCAGGCCATGGAGGCAGGTGCCAGGTCAG
TATTGAGTCACAGTAGAGGCCCCACAAGGACCTGCTTGGGTGAGACCACCTCTCCCCTCTCAGCAGCGCTGGTGGGCTCTTTGTCCTGGT
GCCCAGGAGCCCTCCAGCCCCCTGCCCACAGAAGGGAAGGCCTGCAGAGGGGGCCAGGATCTACCTAACCATTTCCCCACCCCTAAGTCC
CTCAGTGGGCTTTGCCTTATAGGTGCCACAGGGCACAGCTCCATCATTGCCACTGGTTTTTCCTAAGTCATGCACCAAGGACTTCAGAAA
GTTCTTCCTCCGAGTCAGTCAGTGGTGCCGGGACCCCAGGGCAGCCTCCTCGACTCCTGAAGAAAAGGCAGTGCCCGTGGCTGCCTCTGT
CTTCACTCGCTGTTGATGTGACCGCCAGGCCTCCTCTCGTACCTTGGACAAAGGATACACCTGAACCAGAATAGTTTTCTTACCCTCACA
TTGAAATGAGGATTTTGCTTAAAACAGCACTTGCCGCCAGTGGGAGGAGGGAGGTTTTATTTATTCCCACAGTTTCTCCTGGGCCTTCTG
GAATGACCATGTTTTCCTGTGGCGGTGGGTGTGTCATTGCGCCCGCCGTCTTCCAAAGCCTTACTTCCCCAAGCTGCCAGCCAGGAGGTG
ATAACCACCCTCCCAGAGTTTCTCTCGGCTCTTTTTTTAAAAGTCCCCCAACAAATAGGATTCTTGCTGGGAAAGGAAGTTCGGTAAGGA
AATGTCAAATCTGGTTTTTAAACAAGGTCCAACCCTGCAATGAAGCAGCCACTTCAGCCCAGAGAGATTATAAGAACTGATGTGGCCAGA
GTGCCTACCCACTGTGGCCCCGGTGCTCTGCCCCCACGCCCCGACCATCTGGTCTTGGTAGATGTCCCTAGACGGGCTGAGCCATGTGCA
ATAAGAACATAGATCCTAAAGGATCCTCTGGAAGCTGTATTTCTTGAATTAGAATTCTCAAATTGTACATCTGTTAATATATGTTTATTA

>97577_97577_3_USP54-DNAJB12_USP54_chr10_75331179_ENST00000408019_DNAJB12_chr10_74104885_ENST00000444643_length(amino acids)=338AA_BP=7
MHLLRSQALIESLNQKPQTAGDQPPPTDTTHATHRKAGGTDAPSANGEAGGESTKGYTAEQVAAVKRVKQCKDYYEILGVSRGASDEDLK
KAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKSQAARHGHGHGDFHRGFEADISPEDLFNMFFGGGFPSSNV
HVYSNGRMRYTYQQRQDRRDNQGDGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSPRPSVGHIHRRVTDHLGVVYYVGDTFSEEYTG

--------------------------------------------------------------
>97577_97577_4_USP54-DNAJB12_USP54_chr10_75331179_ENST00000428547_DNAJB12_chr10_74104885_ENST00000394903_length(transcript)=3070nt_BP=257nt
GCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAA
CCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGG
ATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGCCCTGATTGAGTC
CCTCAACCAGAAACCACAGACTGCCGGTGACCAACCCCCACCCACAGACACAACCCATGCCACCCACAGGAAAGCAGGTGGGACCGATGC
CCCCTCGGCCAACGGTGAAGCTGGAGGAGAGAGCACCAAAGGCTACACTGCAGAACAGGTTGCAGCTGTGAAAAGGGTCAAGCAATGTAA
AGATTACTATGAGATCCTGGGGGTGAGCAGAGGGGCCTCGGATGAGGACCTGAAGAAGGCCTACCGCAGACTGGCCCTCAAATTCCACCC
AGACAAGAACCACGCACCTGGTGCCACTGAAGCCTTCAAAGCCATTGGCACAGCATATGCGGTACTCAGCAACCCGGAGAAGAGGAAGCA
GTATGACCAGTTCGGCGATGACAAGAGCCAGGCGGCCCGGCACGGCCATGGGCATGGGGATTTCCACCGTGGCTTTGAGGCCGACATCTC
CCCTGAAGACCTCTTCAACATGTTCTTTGGCGGCGGCTTCCCTTCTAGTAACGTCCACGTCTACAGCAACGGCCGCATGCGCTATACCTA
CCAGCAAAGGCAGGACCGCAGGGACAACCAGGGTGATGGCGGGCTAGGGGTGTTTGTGCAGCTGATGCCTATCCTCATCCTGATTCTCGT
GTCAGCTCTCAGCCAGCTCATGGTCTCCAGTCCACCCTACAGTCTGAGTCCAAGACCGTCCGTGGGCCACATCCACAGGCGAGTCACTGA
CCACCTGGGTGTCGTCTACTATGTGGGAGACACTTTCTCCGAAGAGTACACAGGCTCCAGCCTCAAAACAGTCGAGCGGAATGTGGAAGA
TGATTATATCGCCAACCTCCGGAACAACTGCTGGAAGGAGAAGCAGCAGAAGGAAGGCTTGCTGTACCGGGCACGCTACTTTGGCGACAC
AGATATGTACCACAGAGCACAGAAGATGGGCACCCCCAGCTGCAGCCGACTGTCAGAGGTGCAGGCCTCCCTGCATGGATAGTCCTGGGC
CAGCCACACCACCGAGGTCCAAACTATGAAATCCCTGGAGAATTTTTGGTGACATGCACTGAGCCAAGGTGATGGACTGTATATTTGAGG
AAAGACAAACAAAGAAACAAAATTAAAATGGAATTGGAGGCCGAACGCTGCACAGCTGCCCTCTCTCTCACCCAGTAAATGCAGAAAGCT
CTTAGGACAGACAGAAAACCTGCCATGGGGCTGCTTCCCTCCCTCGCAGGGCTGGCGGAGGCTCCGCATCGCCTCTCTCCTAGGATACAG
AAACCATGGCAACGAAAGTAGAATGTAAAACTCGCAGCAGATATCAGTGGGAAGGGCTGGGGGAGGGGGCACCCAGCTGCCTTTCCTCCC
TCACAGGAGCCACCACCAGCCACCTCTCAGGAGAAGCCAGAGGCCCTGGCCAAAGATAGGAGGAAGAAAGAGAACTCTCCATAGAATGTA
ATTTATAGATGCGTGTATATGTATATATATCTATTTATATGTAAATAGGCATATATGAAGATATATATATATATAGTCTACTTTTTAAAC
TCTGCAGGGATTTGGTTAAGTTGTTGAGCTGATTTCTTCCATGTTTTAGAAAATGAGGCCTGTTTGGGGAAGGTACCCTGGTGATGTTTT
TGCTAGACATTAGCTGTAGCTGACAGCATAAGGAGAGTCGCATCAGAGCTTTTCACAGCCCCCCGAAACCCCAGCCTGGTTTTGATGGCA
GCAGTAATCATGATAGTGTGAACCCGCGAAGGCCTCAGGATTATGGTTAACCTGGAGAGGAGCAGGCCATGGAGGCAGGTGCCAGGTCAG
TATTGAGTCACAGTAGAGGCCCCACAAGGACCTGCTTGGGTGAGACCACCTCTCCCCTCTCAGCAGCGCTGGTGGGCTCTTTGTCCTGGT
GCCCAGGAGCCCTCCAGCCCCCTGCCCACAGAAGGGAAGGCCTGCAGAGGGGGCCAGGATCTACCTAACCATTTCCCCACCCCTAAGTCC
CTCAGTGGGCTTTGCCTTATAGGTGCCACAGGGCACAGCTCCATCATTGCCACTGGTTTTTCCTAAGTCATGCACCAAGGACTTCAGAAA
GTTCTTCCTCCGAGTCAGTCAGTGGTGCCGGGACCCCAGGGCAGCCTCCTCGACTCCTGAAGAAAAGGCAGTGCCCGTGGCTGCCTCTGT
CTTCACTCGCTGTTGATGTGACCGCCAGGCCTCCTCTCGTACCTTGGACAAAGGATACACCTGAACCAGAATAGTTTTCTTACCCTCACA
TTGAAATGAGGATTTTGCTTAAAACAGCACTTGCCGCCAGTGGGAGGAGGGAGGTTTTATTTATTCCCACAGTTTCTCCTGGGCCTTCTG
GAATGACCATGTTTTCCTGTGGCGGTGGGTGTGTCATTGCGCCCGCCGTCTTCCAAAGCCTTACTTCCCCAAGCTGCCAGCCAGGAGGTG
ATAACCACCCTCCCAGAGTTTCTCTCGGCTCTTTTTTTAAAAGTCCCCCAACAAATAGGATTCTTGCTGGGAAAGGAAGTTCGGTAAGGA
AATGTCAAATCTGGTTTTTAAACAAGGTCCAACCCTGCAATGAAGCAGCCACTTCAGCCCAGAGAGATTATAAGAACTGATGTGGCCAGA
GTGCCTACCCACTGTGGCCCCGGTGCTCTGCCCCCACGCCCCGACCATCTGGTCTTGGTAGATGTCCCTAGACGGGCTGAGCCATGTGCA
ATAAGAACATAGATCCTAAAGGATCCTCTGGAAGCTGTATTTCTTGAATTAGAATTCTCAAATTGTACATCTGTTAATATATGTTTATTA

>97577_97577_4_USP54-DNAJB12_USP54_chr10_75331179_ENST00000428547_DNAJB12_chr10_74104885_ENST00000394903_length(amino acids)=338AA_BP=7
MHLLRSQALIESLNQKPQTAGDQPPPTDTTHATHRKAGGTDAPSANGEAGGESTKGYTAEQVAAVKRVKQCKDYYEILGVSRGASDEDLK
KAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKSQAARHGHGHGDFHRGFEADISPEDLFNMFFGGGFPSSNV
HVYSNGRMRYTYQQRQDRRDNQGDGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSPRPSVGHIHRRVTDHLGVVYYVGDTFSEEYTG

--------------------------------------------------------------
>97577_97577_5_USP54-DNAJB12_USP54_chr10_75331179_ENST00000428547_DNAJB12_chr10_74104885_ENST00000444643_length(transcript)=3069nt_BP=257nt
GCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAA
CCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGG
ATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGCCCTGATTGAGTC
CCTCAACCAGAAACCACAGACTGCCGGTGACCAACCCCCACCCACAGACACAACCCATGCCACCCACAGGAAAGCAGGTGGGACCGATGC
CCCCTCGGCCAACGGTGAAGCTGGAGGAGAGAGCACCAAAGGCTACACTGCAGAACAGGTTGCAGCTGTGAAAAGGGTCAAGCAATGTAA
AGATTACTATGAGATCCTGGGGGTGAGCAGAGGGGCCTCGGATGAGGACCTGAAGAAGGCCTACCGCAGACTGGCCCTCAAATTCCACCC
AGACAAGAACCACGCACCTGGTGCCACTGAAGCCTTCAAAGCCATTGGCACAGCATATGCGGTACTCAGCAACCCGGAGAAGAGGAAGCA
GTATGACCAGTTCGGCGATGACAAGAGCCAGGCGGCCCGGCACGGCCATGGGCATGGGGATTTCCACCGTGGCTTTGAGGCCGACATCTC
CCCTGAAGACCTCTTCAACATGTTCTTTGGCGGCGGCTTCCCTTCTAGTAACGTCCACGTCTACAGCAACGGCCGCATGCGCTATACCTA
CCAGCAAAGGCAGGACCGCAGGGACAACCAGGGTGATGGCGGGCTAGGGGTGTTTGTGCAGCTGATGCCTATCCTCATCCTGATTCTCGT
GTCAGCTCTCAGCCAGCTCATGGTCTCCAGTCCACCCTACAGTCTGAGTCCAAGACCGTCCGTGGGCCACATCCACAGGCGAGTCACTGA
CCACCTGGGTGTCGTCTACTATGTGGGAGACACTTTCTCCGAAGAGTACACAGGCTCCAGCCTCAAAACAGTCGAGCGGAATGTGGAAGA
TGATTATATCGCCAACCTCCGGAACAACTGCTGGAAGGAGAAGCAGCAGAAGGAAGGCTTGCTGTACCGGGCACGCTACTTTGGCGACAC
AGATATGTACCACAGAGCACAGAAGATGGGCACCCCCAGCTGCAGCCGACTGTCAGAGGTGCAGGCCTCCCTGCATGGATAGTCCTGGGC
CAGCCACACCACCGAGGTCCAAACTATGAAATCCCTGGAGAATTTTTGGTGACATGCACTGAGCCAAGGTGATGGACTGTATATTTGAGG
AAAGACAAACAAAGAAACAAAATTAAAATGGAATTGGAGGCCGAACGCTGCACAGCTGCCCTCTCTCTCACCCAGTAAATGCAGAAAGCT
CTTAGGACAGACAGAAAACCTGCCATGGGGCTGCTTCCCTCCCTCGCAGGGCTGGCGGAGGCTCCGCATCGCCTCTCTCCTAGGATACAG
AAACCATGGCAACGAAAGTAGAATGTAAAACTCGCAGCAGATATCAGTGGGAAGGGCTGGGGGAGGGGGCACCCAGCTGCCTTTCCTCCC
TCACAGGAGCCACCACCAGCCACCTCTCAGGAGAAGCCAGAGGCCCTGGCCAAAGATAGGAGGAAGAAAGAGAACTCTCCATAGAATGTA
ATTTATAGATGCGTGTATATGTATATATATCTATTTATATGTAAATAGGCATATATGAAGATATATATATATATAGTCTACTTTTTAAAC
TCTGCAGGGATTTGGTTAAGTTGTTGAGCTGATTTCTTCCATGTTTTAGAAAATGAGGCCTGTTTGGGGAAGGTACCCTGGTGATGTTTT
TGCTAGACATTAGCTGTAGCTGACAGCATAAGGAGAGTCGCATCAGAGCTTTTCACAGCCCCCCGAAACCCCAGCCTGGTTTTGATGGCA
GCAGTAATCATGATAGTGTGAACCCGCGAAGGCCTCAGGATTATGGTTAACCTGGAGAGGAGCAGGCCATGGAGGCAGGTGCCAGGTCAG
TATTGAGTCACAGTAGAGGCCCCACAAGGACCTGCTTGGGTGAGACCACCTCTCCCCTCTCAGCAGCGCTGGTGGGCTCTTTGTCCTGGT
GCCCAGGAGCCCTCCAGCCCCCTGCCCACAGAAGGGAAGGCCTGCAGAGGGGGCCAGGATCTACCTAACCATTTCCCCACCCCTAAGTCC
CTCAGTGGGCTTTGCCTTATAGGTGCCACAGGGCACAGCTCCATCATTGCCACTGGTTTTTCCTAAGTCATGCACCAAGGACTTCAGAAA
GTTCTTCCTCCGAGTCAGTCAGTGGTGCCGGGACCCCAGGGCAGCCTCCTCGACTCCTGAAGAAAAGGCAGTGCCCGTGGCTGCCTCTGT
CTTCACTCGCTGTTGATGTGACCGCCAGGCCTCCTCTCGTACCTTGGACAAAGGATACACCTGAACCAGAATAGTTTTCTTACCCTCACA
TTGAAATGAGGATTTTGCTTAAAACAGCACTTGCCGCCAGTGGGAGGAGGGAGGTTTTATTTATTCCCACAGTTTCTCCTGGGCCTTCTG
GAATGACCATGTTTTCCTGTGGCGGTGGGTGTGTCATTGCGCCCGCCGTCTTCCAAAGCCTTACTTCCCCAAGCTGCCAGCCAGGAGGTG
ATAACCACCCTCCCAGAGTTTCTCTCGGCTCTTTTTTTAAAAGTCCCCCAACAAATAGGATTCTTGCTGGGAAAGGAAGTTCGGTAAGGA
AATGTCAAATCTGGTTTTTAAACAAGGTCCAACCCTGCAATGAAGCAGCCACTTCAGCCCAGAGAGATTATAAGAACTGATGTGGCCAGA
GTGCCTACCCACTGTGGCCCCGGTGCTCTGCCCCCACGCCCCGACCATCTGGTCTTGGTAGATGTCCCTAGACGGGCTGAGCCATGTGCA
ATAAGAACATAGATCCTAAAGGATCCTCTGGAAGCTGTATTTCTTGAATTAGAATTCTCAAATTGTACATCTGTTAATATATGTTTATTA

>97577_97577_5_USP54-DNAJB12_USP54_chr10_75331179_ENST00000428547_DNAJB12_chr10_74104885_ENST00000444643_length(amino acids)=338AA_BP=7
MHLLRSQALIESLNQKPQTAGDQPPPTDTTHATHRKAGGTDAPSANGEAGGESTKGYTAEQVAAVKRVKQCKDYYEILGVSRGASDEDLK
KAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKSQAARHGHGHGDFHRGFEADISPEDLFNMFFGGGFPSSNV
HVYSNGRMRYTYQQRQDRRDNQGDGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSPRPSVGHIHRRVTDHLGVVYYVGDTFSEEYTG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USP54-DNAJB12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP54-DNAJB12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP54-DNAJB12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource