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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP54-PIK3CD (FusionGDB2 ID:97586)

Fusion Gene Summary for USP54-PIK3CD

check button Fusion gene summary
Fusion gene informationFusion gene name: USP54-PIK3CD
Fusion gene ID: 97586
HgeneTgene
Gene symbol

USP54

PIK3CD

Gene ID

159195

22883

Gene nameubiquitin specific peptidase 54calsyntenin 1
SynonymsC10orf29|bA137L10.3|bA137L10.4ALC-ALPHA|CDHR12|CST-1|CSTN1|PIK3CD|XB31alpha|alcalpha1|alcalpha2
Cytomap

10q22.2

1p36.22

Type of geneprotein-codingprotein-coding
Descriptioninactive ubiquitin carboxyl-terminal hydrolase 54inactive ubiquitin-specific peptidase 54ubiquitin specific protease 54ubiquitin specific proteinase 54calsyntenin-1alcadein-alphaalzheimer-related cadherin-like proteincadherin-related family member 12non-classical cadherin XB31alpha
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000339859, ENST00000408019, 
ENST00000428547, ENST00000394811, 
ENST00000319786, ENST00000422491, 
ENST00000497106, 		ENST00000361110, 
ENST00000484851, ENST00000543390, 
ENST00000377346, ENST00000536656, 
Fusion gene scores* DoF score19 X 13 X 9=22238 X 8 X 5=320
# samples 208
** MAII scorelog2(20/2223*10)=-3.47443604325227
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/320*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP54 [Title/Abstract] AND PIK3CD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP54(75280665)-PIK3CD(9775598), # samples:1
Anticipated loss of major functional domain due to fusion event.USP54-PIK3CD seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
USP54-PIK3CD seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
USP54-PIK3CD seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across USP54 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PIK3CD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4ORUSP54chr10

75280665

-PIK3CDchr1

9775598

+


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Fusion Gene ORF analysis for USP54-PIK3CD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000339859ENST00000361110USP54chr10

75280665

-PIK3CDchr1

9775598

+
5CDS-intronENST00000339859ENST00000484851USP54chr10

75280665

-PIK3CDchr1

9775598

+
5CDS-intronENST00000339859ENST00000543390USP54chr10

75280665

-PIK3CDchr1

9775598

+
5CDS-intronENST00000408019ENST00000361110USP54chr10

75280665

-PIK3CDchr1

9775598

+
5CDS-intronENST00000408019ENST00000484851USP54chr10

75280665

-PIK3CDchr1

9775598

+
5CDS-intronENST00000408019ENST00000543390USP54chr10

75280665

-PIK3CDchr1

9775598

+
5CDS-intronENST00000428547ENST00000361110USP54chr10

75280665

-PIK3CDchr1

9775598

+
5CDS-intronENST00000428547ENST00000484851USP54chr10

75280665

-PIK3CDchr1

9775598

+
5CDS-intronENST00000428547ENST00000543390USP54chr10

75280665

-PIK3CDchr1

9775598

+
5UTR-3CDSENST00000394811ENST00000377346USP54chr10

75280665

-PIK3CDchr1

9775598

+
5UTR-3CDSENST00000394811ENST00000536656USP54chr10

75280665

-PIK3CDchr1

9775598

+
5UTR-intronENST00000394811ENST00000361110USP54chr10

75280665

-PIK3CDchr1

9775598

+
5UTR-intronENST00000394811ENST00000484851USP54chr10

75280665

-PIK3CDchr1

9775598

+
5UTR-intronENST00000394811ENST00000543390USP54chr10

75280665

-PIK3CDchr1

9775598

+
Frame-shiftENST00000408019ENST00000377346USP54chr10

75280665

-PIK3CDchr1

9775598

+
Frame-shiftENST00000408019ENST00000536656USP54chr10

75280665

-PIK3CDchr1

9775598

+
Frame-shiftENST00000428547ENST00000377346USP54chr10

75280665

-PIK3CDchr1

9775598

+
Frame-shiftENST00000428547ENST00000536656USP54chr10

75280665

-PIK3CDchr1

9775598

+
In-frameENST00000339859ENST00000377346USP54chr10

75280665

-PIK3CDchr1

9775598

+
In-frameENST00000339859ENST00000536656USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-3CDSENST00000319786ENST00000377346USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-3CDSENST00000319786ENST00000536656USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-3CDSENST00000422491ENST00000377346USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-3CDSENST00000422491ENST00000536656USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-3CDSENST00000497106ENST00000377346USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-3CDSENST00000497106ENST00000536656USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-intronENST00000319786ENST00000361110USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-intronENST00000319786ENST00000484851USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-intronENST00000319786ENST00000543390USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-intronENST00000422491ENST00000361110USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-intronENST00000422491ENST00000484851USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-intronENST00000422491ENST00000543390USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-intronENST00000497106ENST00000361110USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-intronENST00000497106ENST00000484851USP54chr10

75280665

-PIK3CDchr1

9775598

+
intron-intronENST00000497106ENST00000543390USP54chr10

75280665

-PIK3CDchr1

9775598

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339859USP54chr1075280665-ENST00000536656PIK3CDchr19775598+77172583244556481067
ENST00000339859USP54chr1075280665-ENST00000377346PIK3CDchr19775598+74502583244555761043

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339859ENST00000536656USP54chr1075280665-PIK3CDchr19775598+0.0219724230.9780276
ENST00000339859ENST00000377346USP54chr1075280665-PIK3CDchr19775598+0.0243655540.9756344

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Fusion Genomic Features for USP54-PIK3CD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
USP54chr1075280665-PIK3CDchr19775598+4.95E-091
USP54chr1075280665-PIK3CDchr19775598+4.95E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for USP54-PIK3CD


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:75280665/chr1:9775598)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP54chr10:75280665chr1:9775598ENST00000339859-1723736_7708271685.0Coiled coilOntology_term=ECO:0000255
HgeneUSP54chr10:75280665chr1:9775598ENST00000408019-1622736_7708271685.0Coiled coilOntology_term=ECO:0000255
HgeneUSP54chr10:75280665chr1:9775598ENST00000339859-1723559_5708271685.0Compositional biasNote=Poly-Ser
HgeneUSP54chr10:75280665chr1:9775598ENST00000408019-1622559_5708271685.0Compositional biasNote=Poly-Ser
HgeneUSP54chr10:75280665chr1:9775598ENST00000428547-1218559_5706771535.0Compositional biasNote=Poly-Ser
HgeneUSP54chr10:75280665chr1:9775598ENST00000339859-172331_3528271685.0DomainNote=USP
HgeneUSP54chr10:75280665chr1:9775598ENST00000408019-162231_3528271685.0DomainNote=USP
HgeneUSP54chr10:75280665chr1:9775598ENST00000428547-121831_3526771535.0DomainNote=USP
TgenePIK3CDchr10:75280665chr1:9775598ENST00000377346224187_278471045.0DomainPI3K-RBD
TgenePIK3CDchr10:75280665chr1:9775598ENST00000377346224319_476471045.0DomainC2 PI3K-type
TgenePIK3CDchr10:75280665chr1:9775598ENST00000377346224497_674471045.0DomainPIK helical
TgenePIK3CDchr10:75280665chr1:9775598ENST00000377346224774_1041471045.0DomainPI3K/PI4K

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP54chr10:75280665chr1:9775598ENST00000394811-1621736_7700726.0Coiled coilOntology_term=ECO:0000255
HgeneUSP54chr10:75280665chr1:9775598ENST00000428547-1218736_7706771535.0Coiled coilOntology_term=ECO:0000255
HgeneUSP54chr10:75280665chr1:9775598ENST00000339859-1723866_8698271685.0Compositional biasNote=Poly-Gln
HgeneUSP54chr10:75280665chr1:9775598ENST00000394811-1621559_5700726.0Compositional biasNote=Poly-Ser
HgeneUSP54chr10:75280665chr1:9775598ENST00000394811-1621866_8690726.0Compositional biasNote=Poly-Gln
HgeneUSP54chr10:75280665chr1:9775598ENST00000408019-1622866_8698271685.0Compositional biasNote=Poly-Gln
HgeneUSP54chr10:75280665chr1:9775598ENST00000428547-1218866_8696771535.0Compositional biasNote=Poly-Gln
HgeneUSP54chr10:75280665chr1:9775598ENST00000394811-162131_3520726.0DomainNote=USP
TgenePIK3CDchr10:75280665chr1:9775598ENST0000037734622416_105471045.0DomainPI3K-ABD


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Fusion Gene Sequence for USP54-PIK3CD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97586_97586_1_USP54-PIK3CD_USP54_chr10_75280665_ENST00000339859_PIK3CD_chr1_9775598_ENST00000377346_length(transcript)=7450nt_BP=2583nt
GTTTACGGAGACTCGGAACTGGATAAAGGGACCAGGCTACATTGGGAAAGAAGTGGGAAGAAATGGGGTACAGCGACGAGGAGGGCTAAA
TGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAACCTCCA
TAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGGATATCT
TCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGGAATCTTTAACCAGTTTC
AGTGTAGTAGTGAAAAAGTGCTTCCATCTGACACTCTCCGCAGTGCTCTGGCAAAGACTTTCCAGGATGAACAACGTTTCCAGCTGGGAA
TTATGGATGATGCTGCAGAGTGCTTTGAAAACCTCCTGATGAGAATTCACTTCCACATTGCTGATGAAACCAAAGAGGATATATGTACTG
CCCAACACTGCATTTCCCATCAGAAATTTGCAATGACATTGTTTGAGCAGTGTGTATGTACTAGCTGTGGTGCCACTTCTGATCCGCTGC
CTTTCATCCAGATGGTACATTATATCTCCACCACTTCCCTTTGCAATCAGGCTATTTGTATGCTGGAAAGACGAGAGAAACCTTCACCAA
GCATGTTTGGTGAGCTGCTGCAGAATGCCAGCACCATGGGGGATCTGCGGAACTGTCCAAGCAACTGTGGAGAGAGGATCAGGATTCGCC
GTGTGTTGATGAATGCTCCACAGATTATCACGATTGGGCTGGTATGGGACTCAGACCACTCAGACTTAGCAGAAGATGTTATCCACAGCC
TGGGAACCTGCCTTAAGCTGGGTGATCTGTTTTTCAGAGTGACGGATGACCGGGCCAAGCAATCTGAACTGTACTTAGTTGGAATGATCT
GTTACTATGGCAAACATTATTCTACATTCTTTTTTCAAACAAAGATTCGCAAATGGATGTATTTTGATGATGCTCATGTCAAGGAGATTG
GGCCCAAATGGAAGGATGTGGTGACCAAATGCATCAAGGGGCATTATCAGCCCCTGCTGCTGCTTTATGCAGATCCCCAGGGTACCCCAG
TTTCCACCCAGGACCTGCCTCCCCAAGCTGAGTTCCAGTCATACAGCAGGACATGCTACGACAGTGAAGATTCAGGGAGGGAGCCCTCCA
TCTCAAGTGACACTCGAACAGATTCCTCAACGGAGAGCTATCCCTACAAACATTCCCACCATGAGTCTGTGGTCAGTCACTTCTCTTCTG
ATTCTCAGGGGACAGTCATCTATAATGTGGAAAATGATTCCATGTCTCAGAGCAGTCGGGACACAGGACACCTGACTGATAGTGAATGTA
ATCAGAAACACACATCCAAGAAAGGGTCACTGATAGAGCGCAAGAGGAGCTCTGGTCGGGTTAGGAGGAAAGGCGATGAGCCCCAGGCCT
CGGGATACCACAGTGAAGGAGAAACACTGAAAGAGAAGCAGGCTCCTAGAAATGCCTCCAAACCATCCAGCAGCACCAACAGGCTGAGAG
ATTTTAAAGAGACAGTCAGCAATATGATCCATAACAGACCATCCCTGGCTTCTCAGACCAATGTAGGCTCTCACTGCAGGGGCAGAGGAG
GAGACCAGCCTGACAAAAAACCTCCTAGGACCCTGCCTTTACACTCTCGTGACTGGGAAATAGAGAGTACCAGCAGTGAGTCAAAATCCA
GTTCTTCCAGCAAGTATCGTCCCACATGGAGACCCAAACGAGAATCTCTGAATATTGACAGTATCTTTAGTAAGGACAAAAGGAAGCACT
GTGGCTATACCCAGCTTAGCCCCTTTTCTGAGGATTCAGCTAAAGAATTTATACCAGATGAACCAAGCAAGCCACCTTCTTACGACATTA
AATTTGGTGGACCAAGCCCCCAGTACAAGCGCTGGGGCCCAGCACGGCCAGGCTCTCACCTTTTAGAGCAGCACCCCCGACTAATCCAGC
GAATGGAATCTGGCTATGAAAGCAGTGAGAGGAACAGCAGCAGCCCTGTCAGCCTGGATGCAGCCCTGCCTGAGAGCTCAAATGTCTACA
GGGATCCAAGTGCTAAGAGATCAGCTGGGTTGGTTCCTTCCTGGCGTCATATCCCAAAGTCGCACAGCAGTAGCATCCTGGAGGTAGACT
CCACAGCATCCATGGGTGGCTGGACAAAGAGTCAGCCTTTCTCTGGTGAGGAGATATCTTCTAAAAGTGAACTGGATGAATTGCAGGAAG
AGGTGGCCAGGAGGGCGCAGGAACAGGAACTTCGAAGAAAACGGGAGAAGGAGTTAGAGGCAGCGAAAGGGTTTAACCCTCATCCTAGCC
GCTTCATGGACTTGGATGAACTGCAGAATCAGGGGAGGAGTGACGGCTTTGAGAGGTCCCTGCAAGAGGCAGAGTCAGTGTTTGAAGAGT
CACTACATCTGGAACAGAAAGGAGACTGTGCTGCAGCTTTGGCTCTCTGTAATGAAGCTATCTCTGCTGTGGCACCGCGCCCAGTATGAG
CCGCTCTTCCACATGCTCAGTGGCCCCGAGGCCTATGTGTTCACCTGCATCAACCAGACAGCGGAGCAGCAAGAGCTGGAGGACGAGCAA
CGGCGTCTGTGTGACGTGCAGCCCTTCCTGCCCGTCCTGCGCCTGGTGGCCCGTGAGGGCGACCGCGTGAAGAAGCTCATCAACTCACAG
ATCAGCCTCCTCATCGGCAAAGGCCTCCACGAGTTTGACTCCTTGTGCGACCCAGAAGTGAACGACTTTCGCGCCAAGATGTGCCAATTC
TGCGAGGAGGCGGCCGCCCGCCGGCAGCAGCTGGGCTGGGAGGCCTGGCTGCAGTACAGTTTCCCCCTGCAGCTGGAGCCCTCGGCTCAA
ACCTGGGGGCCTGGTACCCTGCGGCTCCCGAACCGGGCCCTTCTGGTCAACGTTAAGTTTGAGGGCAGCGAGGAGAGCTTCACCTTCCAG
GTGTCCACCAAGGACGTGCCGCTGGCGCTGATGGCCTGTGCCCTGCGGAAGAAGGCCACAGTGTTCCGGCAGCCGCTGGTGGAGCAGCCG
GAAGACTACACGCTGCAGGTGAACGGCAGGCATGAGTACCTGTATGGCAGCTACCCGCTCTGCCAGTTCCAGTACATCTGCAGCTGCCTG
CACAGTGGGTTGACCCCTCACCTGACCATGGTCCATTCCTCCTCCATCCTCGCCATGCGGGATGAGCAGAGCAACCCTGCCCCCCAGGTC
CAGAAACCGCGTGCCAAACCACCTCCCATTCCTGCGAAGAAGCCTTCCTCTGTGTCCCTGTGGTCCCTGGAGCAGCCGTTCCGCATCGAG
CTCATCCAGGGCAGCAAAGTGAACGCCGACGAGCGGATGAAGCTGGTGGTGCAGGCCGGGCTTTTCCACGGCAACGAGATGCTGTGCAAG
ACGGTGTCCAGCTCGGAGGTGAGCGTGTGCTCGGAGCCCGTGTGGAAGCAGCGGCTGGAGTTCGACATCAACATCTGCGACCTGCCCCGC
ATGGCCCGTCTCTGCTTTGCGCTGTACGCCGTGATCGAGAAAGCCAAGAAGGCTCGCTCCACCAAGAAGAAGTCCAAGAAGGCGGACTGC
CCCATTGCCTGGGCCAACCTCATGCTGTTTGACTACAAGGACCAGCTTAAGACCGGGGAACGCTGCCTCTACATGTGGCCCTCCGTCCCA
GATGAGAAGGGCGAGCTGCTGAACCCCACGGGCACTGTGCGCAGTAACCCCAACACGGATAGCGCCGCTGCCCTGCTCATCTGCCTGCCC
GAGGTGGCCCCGCACCCCGTGTACTACCCCGCCCTGGAGAAGATCTTGGAGCTGGGGCGACACAGCGAGTGTGTGCATGTCACCGAGGAG
GAGCAGCTGCAGCTGCGGGAAATCCTGGAGCGGCGGGGGTCTGGGGAGCTGTATGAGCACGAGAAGGACCTGGTGTGGAAGCTGCGGCAT
GAAGTCCAGGAGCACTTCCCGGAGGCGCTAGCCCGGCTGCTGCTGGTCACCAAGTGGAACAAGCATGAGGATGTGGCCCAGATGCTCTAC
CTGCTGTGCTCCTGGCCGGAGCTGCCCGTCCTGAGCGCCCTGGAGCTGCTAGACTTCAGCTTCCCCGATTGCCACGTAGGCTCCTTCGCC
ATCAAGTCGCTGCGGAAACTGACGGACGATGAGCTGTTCCAGTACCTGCTGCAGCTGGTGCAGGTGCTCAAGTACGAGTCCTACCTGGAC
TGCGAGCTGACCAAATTCCTGCTGGACCGGGCCCTGGCCAACCGCAAGATCGGCCACTTCCTTTTCTGGCACCTCCGCTCCGAGATGCAC
GTGCCGTCGGTGGCCCTGCGCTTCGGCCTCATCCTGGAGGCCTACTGCAGGGGCAGCACCCACCACATGAAGGTGCTGATGAAGCAGGGG
GAAGCACTGAGCAAACTGAAGGCCCTGAATGACTTCGTCAAGCTGAGCTCTCAGAAGACCCCCAAGCCCCAGACCAAGGAGCTGATGCAC
TTGTGCATGCGGCAGGAGGCCTACCTAGAGGCCCTCTCCCACCTGCAGTCCCCACTCGACCCCAGCACCCTGCTGGCTGAAGTCTGCGTG
GAGCAGTGCACCTTCATGGACTCCAAGATGAAGCCCCTGTGGATCATGTACAGCAACGAGGAGGCAGGCAGCGGCGGCAGCGTGGGCATC
ATCTTTAAGAACGGGGATGACCTCCGGCAGGACATGCTGACCCTGCAGATGATCCAGCTCATGGACGTCCTGTGGAAGCAGGAGGGGCTG
GACCTGAGGATGACCCCCTATGGCTGCCTCCCCACCGGGGACCGCACAGGCCTCATTGAGGTGGTACTCCGTTCAGACACCATCGCCAAC
ATCCAACTCAACAAGAGCAACATGGCAGCCACAGCCGCCTTCAACAAGGATGCCCTGCTCAACTGGCTGAAGTCCAAGAACCCGGGGGAG
GCCCTGGATCGAGCCATTGAGGAGTTCACCCTCTCCTGTGCTGGCTATTGTGTGGCCACATATGTGCTGGGCATTGGCGATCGGCACAGC
GACAACATCATGATCCGAGAGAGTGGGCAGCTGTTCCACATTGATTTTGGCCACTTTCTGGGGAATTTCAAGACCAAGTTTGGAATCAAC
CGCGAGCGTGTCCCATTCATCCTCACCTACGACTTTGTCCATGTGATTCAGCAGGGGAAGACTAATAATAGTGAGAAATTTGAACGGTTC
CGGGGCTACTGTGAAAGGGCCTACACCATCCTGCGGCGCCACGGGCTTCTCTTCCTCCACCTCTTTGCCCTGATGCGGGCGGCAGGCCTG
CCTGAGCTCAGCTGCTCCAAAGACATCCAGTATCTCAAGGACTCCCTGGCACTGGGGAAAACAGAGGAGGAGGCACTGAAGCACTTCCGA
GTGAAGTTTAACGAAGCCCTCCGTGAGAGCTGGAAAACCAAAGTGAACTGGCTGGCCCACAACGTGTCCAAAGACAACAGGCAGTAGTGG
CTCCTCCCAGCCCTGGGCCCAAGAGGAGGCGGCTGCGGGTCGTGGGGACCAAGCACATTGGTCCTAAAGGGGCTGAAGAGCCTGAACTGC
ACCTAACGGGAAAGAACCGACATGGCTGCCTTTTGTTTACACTGGTTATTTATTTATGACTTGAAATAGTTTAAGGAGCTAAACAGCCAT
AAACGGAAACGCCTCCTTCATGCAGCGGCGGTGCTGGGCCCCCCGAGGCTGCACCTGGCTCTCGGCTGAGGATTGTCACCCCAAGTCTTC
CAGCTGGTGGATCTGGGCCCAGCAAAGACTGTTCTCCTCCCGAGGGAACCTTCTTCCCAGGCCTCCCGCCAGACTGCCTGGGTCCTGGCG
CCTGGCGGTCACCTGGTGCCTACTGTCCGACAGGATGCCTTGATCCTCGTGCGACCCACCCTGTGTATCCTCCCTAGACTGAGTTCTGGC
AGCTCCCCGAGGCAGCCGGGGTACCCTCTAGATTCAGGGATGCTTGCTCTCCACTTTTCAAGTGGGTCTTGGGTACGAGAATTCCCTCAT
CTTTCTCTACTGTAAAGTGATTTTGTTTGCAGGTAAGAAAATAATAGATGACTCACCACACCTCTACGGCTGGGGAGATCAGGCCCAGCC
CCATAAAGGAGAATCTACGCTGGTCCTCAGGACGTGTTAAAGAGATCTGGGCCTCATGTAGCTCACCCCGGTCACGCATGAAGGCAAAAG
CAGGTCAGAAGCGAATACTCTGCCATTATCTCAAAAATCTTTTTTTTTTTTTTGAGATGGGGTCTTCCTCTGTTGCCCAGGCTGGAGTGC
AGTGGTGCAATCTTGGCTCACTGTAACCTCCGCCTCCCAGGTTCAAGTGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGT
GTGCACCACCGTACCCAGCTAATTTTTGTATTTTAGTAGAGACGGGGGTTTCACCATGTTGGCTGGGCTGGTCTCGAACTCCTGACCTCA
GGTGATCCACCCGCCTGAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACTCTGCCATTGTCTAAGCCACCT
CTGAAAGCAGGTTTTAACAAAAGGATGAGGCCAGAACTCTTCCAGAACCATCACCTTTGGGAACCTGCTGTGAGAGTGCTGAGGTACCAG
AAGTGTGAGAACGAGGGGGCGTGCTGGGATCTTTCTCTCTGACTATACTTAGTTTGAAATGGTGCAGGCTTAGTCTTAAGCCTCCAAAGG
CCTGGATTTGAGCAGCTTTAGAAATGCAGGTTCTAGGGCTTCTCCCAGCCTTCAGAAGCCAACTAACTCTGCAGATGGGGCTAGGACTGT
GGGCTTTTAGCAGCCCACAGGTGATCCTAACATATCAGGCCATGGACTCAGGACCTGCCCGGTGATGCTGTTGATTTCTCAAAGGTCTTC
CAAAACTCAACAGAGCCAGAAGTAGCCGCCCGCTCAGCGGCTCAGGTGCCAGCTCTGTTCTGATTCACCAGGGGTCCGTCAGTAGTCATT
GCCACCCGCGGGGCACCTCCCTGGCCACACGCCTGTTCCCAGCAAGTGCTGAAACTCACTAGACCGTCTGCCTGTTTCGAAATGGGGAAA
GCCGTGCGTGCGCGTTATTTATTTAAGTGCGCCTGTGTGCGCGGGTGTGGGAGCACACTTTGCAAAGCCACAGCGTTTCTGGTTTTGGGT
GTACAGTCTTGTGTGCCTGGCGAGAAGAATATTTTCTATTTTTTTAAGTCATTTCATGTTTCTGTCTGGGGAAGGCAAGTTAGTTAAGTA

>97586_97586_1_USP54-PIK3CD_USP54_chr10_75280665_ENST00000339859_PIK3CD_chr1_9775598_ENST00000377346_length(amino acids)=1043AA_BP=44
MNCRIRGGVTALRGPCKRQSQCLKSHYIWNRKETVLQLWLSVMKLSLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCD
VQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPG
TLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLT
PHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSS
EVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGE
LLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEH
FPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTK
FLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQ
EAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMT
PYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMI
RESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSC

--------------------------------------------------------------
>97586_97586_2_USP54-PIK3CD_USP54_chr10_75280665_ENST00000339859_PIK3CD_chr1_9775598_ENST00000536656_length(transcript)=7717nt_BP=2583nt
GTTTACGGAGACTCGGAACTGGATAAAGGGACCAGGCTACATTGGGAAAGAAGTGGGAAGAAATGGGGTACAGCGACGAGGAGGGCTAAA
TGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAACCTCCA
TAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGGATATCT
TCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGGAATCTTTAACCAGTTTC
AGTGTAGTAGTGAAAAAGTGCTTCCATCTGACACTCTCCGCAGTGCTCTGGCAAAGACTTTCCAGGATGAACAACGTTTCCAGCTGGGAA
TTATGGATGATGCTGCAGAGTGCTTTGAAAACCTCCTGATGAGAATTCACTTCCACATTGCTGATGAAACCAAAGAGGATATATGTACTG
CCCAACACTGCATTTCCCATCAGAAATTTGCAATGACATTGTTTGAGCAGTGTGTATGTACTAGCTGTGGTGCCACTTCTGATCCGCTGC
CTTTCATCCAGATGGTACATTATATCTCCACCACTTCCCTTTGCAATCAGGCTATTTGTATGCTGGAAAGACGAGAGAAACCTTCACCAA
GCATGTTTGGTGAGCTGCTGCAGAATGCCAGCACCATGGGGGATCTGCGGAACTGTCCAAGCAACTGTGGAGAGAGGATCAGGATTCGCC
GTGTGTTGATGAATGCTCCACAGATTATCACGATTGGGCTGGTATGGGACTCAGACCACTCAGACTTAGCAGAAGATGTTATCCACAGCC
TGGGAACCTGCCTTAAGCTGGGTGATCTGTTTTTCAGAGTGACGGATGACCGGGCCAAGCAATCTGAACTGTACTTAGTTGGAATGATCT
GTTACTATGGCAAACATTATTCTACATTCTTTTTTCAAACAAAGATTCGCAAATGGATGTATTTTGATGATGCTCATGTCAAGGAGATTG
GGCCCAAATGGAAGGATGTGGTGACCAAATGCATCAAGGGGCATTATCAGCCCCTGCTGCTGCTTTATGCAGATCCCCAGGGTACCCCAG
TTTCCACCCAGGACCTGCCTCCCCAAGCTGAGTTCCAGTCATACAGCAGGACATGCTACGACAGTGAAGATTCAGGGAGGGAGCCCTCCA
TCTCAAGTGACACTCGAACAGATTCCTCAACGGAGAGCTATCCCTACAAACATTCCCACCATGAGTCTGTGGTCAGTCACTTCTCTTCTG
ATTCTCAGGGGACAGTCATCTATAATGTGGAAAATGATTCCATGTCTCAGAGCAGTCGGGACACAGGACACCTGACTGATAGTGAATGTA
ATCAGAAACACACATCCAAGAAAGGGTCACTGATAGAGCGCAAGAGGAGCTCTGGTCGGGTTAGGAGGAAAGGCGATGAGCCCCAGGCCT
CGGGATACCACAGTGAAGGAGAAACACTGAAAGAGAAGCAGGCTCCTAGAAATGCCTCCAAACCATCCAGCAGCACCAACAGGCTGAGAG
ATTTTAAAGAGACAGTCAGCAATATGATCCATAACAGACCATCCCTGGCTTCTCAGACCAATGTAGGCTCTCACTGCAGGGGCAGAGGAG
GAGACCAGCCTGACAAAAAACCTCCTAGGACCCTGCCTTTACACTCTCGTGACTGGGAAATAGAGAGTACCAGCAGTGAGTCAAAATCCA
GTTCTTCCAGCAAGTATCGTCCCACATGGAGACCCAAACGAGAATCTCTGAATATTGACAGTATCTTTAGTAAGGACAAAAGGAAGCACT
GTGGCTATACCCAGCTTAGCCCCTTTTCTGAGGATTCAGCTAAAGAATTTATACCAGATGAACCAAGCAAGCCACCTTCTTACGACATTA
AATTTGGTGGACCAAGCCCCCAGTACAAGCGCTGGGGCCCAGCACGGCCAGGCTCTCACCTTTTAGAGCAGCACCCCCGACTAATCCAGC
GAATGGAATCTGGCTATGAAAGCAGTGAGAGGAACAGCAGCAGCCCTGTCAGCCTGGATGCAGCCCTGCCTGAGAGCTCAAATGTCTACA
GGGATCCAAGTGCTAAGAGATCAGCTGGGTTGGTTCCTTCCTGGCGTCATATCCCAAAGTCGCACAGCAGTAGCATCCTGGAGGTAGACT
CCACAGCATCCATGGGTGGCTGGACAAAGAGTCAGCCTTTCTCTGGTGAGGAGATATCTTCTAAAAGTGAACTGGATGAATTGCAGGAAG
AGGTGGCCAGGAGGGCGCAGGAACAGGAACTTCGAAGAAAACGGGAGAAGGAGTTAGAGGCAGCGAAAGGGTTTAACCCTCATCCTAGCC
GCTTCATGGACTTGGATGAACTGCAGAATCAGGGGAGGAGTGACGGCTTTGAGAGGTCCCTGCAAGAGGCAGAGTCAGTGTTTGAAGAGT
CACTACATCTGGAACAGAAAGGAGACTGTGCTGCAGCTTTGGCTCTCTGTAATGAAGCTATCTCTGCTGTGGCACCGCGCCCAGTATGAG
CCGCTCTTCCACATGCTCAGTGGCCCCGAGGCCTATGTGTTCACCTGCATCAACCAGACAGCGGAGCAGCAAGAGCTGGAGGACGAGCAA
CGGCGTCTGTGTGACGTGCAGCCCTTCCTGCCCGTCCTGCGCCTGGTGGCCCGTGAGGGCGACCGCGTGAAGAAGCTCATCAACTCACAG
ATCAGCCTCCTCATCGGCAAAGGCCTCCACGAGTTTGACTCCTTGTGCGACCCAGAAGTGAACGACTTTCGCGCCAAGATGTGCCAATTC
TGCGAGGAGGCGGCCGCCCGCCGGCAGCAGCTGGGCTGGGAGGCCTGGCTGCAGTACAGTTTCCCCCTGCAGCTGGAGCCCTCGGCTCAA
ACCTGGGGGCCTGGTACCCTGCGGCTCCCGAACCGGGCCCTTCTGGTCAACGTTAAGTTTGAGGGCAGCGAGGAGAGCTTCACCTTCCAG
GTGTCCACCAAGGACGTGCCGCTGGCGCTGATGGCCTGTGCCCTGCGGAAGAAGGCCACAGTGTTCCGGCAGCCGCTGGTGGAGCAGCCG
GAAGACTACACGCTGCAGGTGAACGGCAGGCATGAGTACCTGTATGGCAGCTACCCGCTCTGCCAGTTCCAGGTCCAGAAACCGCGTGCC
AAACCACCTCCCATTCCTGCGAAGAAGCCTTCCTCTGTGTCCCTGTGGTCCCTGGAGCAGCCGTTCCGCATCGAGCTCATCCAGGGCAGC
AAAGTGAACGCCGACGAGCGGATGAAGCTGGTGGTGCAGGCCGGGCTTTTCCACGGCAACGAGATGCTGTGCAAGACGGTGTCCAGCTCG
GAGGTGAGCGTGTGCTCGGAGCCCGTGTGGAAGCAGCGGCTGGAGTTCGACATCAACATCTGCGACCTGCCCCGCATGGCCCGTCTCTGC
TTTGCGCTGTACGCCGTGATCGAGAAAGCCAAGAAGGCTCGCTCCACCAAGAAGAAGTCCAAGAAGGCGGACTGCCCCATTGCCTGGGCC
AACCTCATGCTGTTTGACTACAAGGACCAGCTTAAGACCGGGGAACGCTGCCTCTACATGTGGCCCTCCGTCCCAGATGAGAAGGGCGAG
CTGCTGAACCCCACGGGCACTGTGCGCAGTAACCCCAACACGGATAGCGCCGCTGCCCTGCTCATCTGCCTGCCCGAGGTGGCCCCGCAC
CCCGTGTACTACCCCGCCCTGGAGAAGCTGCCAGGAGGGATGCTCTTGGCATCTCGTGAGTGGAGGCCAGAGCTGCTGTGGATGCGCCTC
CATGCAGAGGACAGCGCCCCCTCAAGGATGATTGGGGTGGCAATGCCCGGCCTGGGGGTCCTGCCCGGGCTGGTCCAGGCCCCTGGGGAC
GCTGAGTGCAGCCGTTTGTTGCAGATCTTGGAGCTGGGGCGACACAGCGAGTGTGTGCATGTCACCGAGGAGGAGCAGCTGCAGCTGCGG
GAAATCCTGGAGCGGCGGGGGTCTGGGGAGCTGTATGAGCACGAGAAGGACCTGGTGTGGAAGCTGCGGCATGAAGTCCAGGAGCACTTC
CCGGAGGCGCTAGCCCGGCTGCTGCTGGTCACCAAGTGGAACAAGCATGAGGATGTGGCCCAGATGCTCTACCTGCTGTGCTCCTGGCCG
GAGCTGCCCGTCCTGAGCGCCCTGGAGCTGCTAGACTTCAGCTTCCCCGATTGCCACGTAGGCTCCTTCGCCATCAAGTCGCTGCGGAAA
CTGACGGACGATGAGCTGTTCCAGTACCTGCTGCAGCTGGTGCAGGTGCTCAAGTACGAGTCCTACCTGGACTGCGAGCTGACCAAATTC
CTGCTGGACCGGGCCCTGGCCAACCGCAAGATCGGCCACTTCCTTTTCTGGCACCTCCGCTCCGAGATGCACGTGCCGTCGGTGGCCCTG
CGCTTCGGCCTCATCCTGGAGGCCTACTGCAGGGGCAGCACCCACCACATGAAGGTGCTGATGAAGCAGGGGGAAGCACTGAGCAAACTG
AAGGCCCTGAATGACTTCGTCAAGCTGAGCTCTCAGAAGACCCCCAAGCCCCAGACCAAGGAGCTGATGCACTTGTGCATGCGGCAGGAG
GCCTACCTAGAGGCCCTCTCCCACCTGCAGTCCCCACTCGACCCCAGCACCCTGCTGGCTGAAGTCTGCGTGGAGCAGTGCACCTTCATG
GACTCCAAGATGAAGCCCCTGTGGATCATGTACAGCAACGAGGAGGCAGGCAGCGGCGGCAGCGTGGGCATCATCTTTAAGAACGGGGAT
GACCTCCGGCAGGACATGCTGACCCTGCAGATGATCCAGCTCATGGACGTCCTGTGGAAGCAGGAGGGGCTGGACCTGAGGATGACCCCC
TATGGCTGCCTCCCCACCGGGGACCGCACAGGCCTCATTGAGGTGGTACTCCGTTCAGACACCATCGCCAACATCCAACTCAACAAGAGC
AACATGGCAGCCACAGCCGCCTTCAACAAGGATGCCCTGCTCAACTGGCTGAAGTCCAAGAACCCGGGGGAGGCCCTGGATCGAGCCATT
GAGGAGTTCACCCTCTCCTGTGCTGGCTATTGTGTGGCCACATATGTGCTGGGCATTGGCGATCGGCACAGCGACAACATCATGATCCGA
GAGAGTGGGCAGCTGTTCCACATTGATTTTGGCCACTTTCTGGGGAATTTCAAGACCAAGTTTGGAATCAACCGCGAGCGTGTCCCATTC
ATCCTCACCTACGACTTTGTCCATGTGATTCAGCAGGGGAAGACTAATAATAGTGAGAAATTTGAACGGTTCCGGGGCTACTGTGAAAGG
GCCTACACCATCCTGCGGCGCCACGGGCTTCTCTTCCTCCACCTCTTTGCCCTGATGCGGGCGGCAGGCCTGCCTGAGCTCAGCTGCTCC
AAAGACATCCAGTATCTCAAGGACTCCCTGGCACTGGGGAAAACAGAGGAGGAGGCACTGAAGCACTTCCGAGTGAAGTTTAACGAAGCC
CTCCGTGAGAGCTGGAAAACCAAAGTGAACTGGCTGGCCCACAACGTGTCCAAAGACAACAGGCAGTAGTGGCTCCTCCCAGCCCTGGGC
CCAAGAGGAGGCGGCTGCGGGTCGTGGGGACCAAGCACATTGGTCCTAAAGGGGCTGAAGAGCCTGAACTGCACCTAACGGGAAAGAACC
GACATGGCTGCCTTTTGTTTACACTGGTTATTTATTTATGACTTGAAATAGTTTAAGGAGCTAAACAGCCATAAACGGAAACGCCTCCTT
CATGCAGCGGCGGTGCTGGGCCCCCCGAGGCTGCACCTGGCTCTCGGCTGAGGATTGTCACCCCAAGTCTTCCAGCTGGTGGATCTGGGC
CCAGCAAAGACTGTTCTCCTCCCGAGGGAACCTTCTTCCCAGGCCTCCCGCCAGACTGCCTGGGTCCTGGCGCCTGGCGGTCACCTGGTG
CCTACTGTCCGACAGGATGCCTTGATCCTCGTGCGACCCACCCTGTGTATCCTCCCTAGACTGAGTTCTGGCAGCTCCCCGAGGCAGCCG
GGGTACCCTCTAGATTCAGGGATGCTTGCTCTCCACTTTTCAAGTGGGTCTTGGGTACGAGAATTCCCTCATCTTTCTCTACTGTAAAGT
GATTTTGTTTGCAGGTAAGAAAATAATAGATGACTCACCACACCTCTACGGCTGGGGAGATCAGGCCCAGCCCCATAAAGGAGAATCTAC
GCTGGTCCTCAGGACGTGTTAAAGAGATCTGGGCCTCATGTAGCTCACCCCGGTCACGCATGAAGGCAAAAGCAGGTCAGAAGCGAATAC
TCTGCCATTATCTCAAAAATCTTTTTTTTTTTTTTGAGATGGGGTCTTCCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCAATCTTGGCT
CACTGTAACCTCCGCCTCCCAGGTTCAAGTGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGTGCACCACCGTACCCAG
CTAATTTTTGTATTTTAGTAGAGACGGGGGTTTCACCATGTTGGCTGGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTGA
GCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACTCTGCCATTGTCTAAGCCACCTCTGAAAGCAGGTTTTAAC
AAAAGGATGAGGCCAGAACTCTTCCAGAACCATCACCTTTGGGAACCTGCTGTGAGAGTGCTGAGGTACCAGAAGTGTGAGAACGAGGGG
GCGTGCTGGGATCTTTCTCTCTGACTATACTTAGTTTGAAATGGTGCAGGCTTAGTCTTAAGCCTCCAAAGGCCTGGATTTGAGCAGCTT
TAGAAATGCAGGTTCTAGGGCTTCTCCCAGCCTTCAGAAGCCAACTAACTCTGCAGATGGGGCTAGGACTGTGGGCTTTTAGCAGCCCAC
AGGTGATCCTAACATATCAGGCCATGGACTCAGGACCTGCCCGGTGATGCTGTTGATTTCTCAAAGGTCTTCCAAAACTCAACAGAGCCA
GAAGTAGCCGCCCGCTCAGCGGCTCAGGTGCCAGCTCTGTTCTGATTCACCAGGGGTCCGTCAGTAGTCATTGCCACCCGCGGGGCACCT
CCCTGGCCACACGCCTGTTCCCAGCAAGTGCTGAAACTCACTAGACCGTCTGCCTGTTTCGAAATGGGGAAAGCCGTGCGTGCGCGTTAT
TTATTTAAGTGCGCCTGTGTGCGCGGGTGTGGGAGCACACTTTGCAAAGCCACAGCGTTTCTGGTTTTGGGTGTACAGTCTTGTGTGCCT
GGCGAGAAGAATATTTTCTATTTTTTTAAGTCATTTCATGTTTCTGTCTGGGGAAGGCAAGTTAGTTAAGTATCACTGATGTGGGTTGAG
ACCAGCACTCTGTGAAACCTTGAAATGAGAAGTAAAGGCAGATGAAAAGAAAGAAAAAGCCTTTTTATGTTCTTTTATGTTCTCGGCTCA
AAAAGAAACAAGGGAGTGTAGGTTTAAAACCAAAACAGGAGAGAAGACAAACCCCGCTCCGGCTGGAGTTAGTTAGAACCAGAACTTTAT

>97586_97586_2_USP54-PIK3CD_USP54_chr10_75280665_ENST00000339859_PIK3CD_chr1_9775598_ENST00000536656_length(amino acids)=1067AA_BP=44
MNCRIRGGVTALRGPCKRQSQCLKSHYIWNRKETVLQLWLSVMKLSLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCD
VQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPG
TLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQVQKPRAKPPPI
PAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYA
VIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYP
ALEKLPGGMLLASREWRPELLWMRLHAEDSAPSRMIGVAMPGLGVLPGLVQAPGDAECSRLLQILELGRHSECVHVTEEEQLQLREILER
RGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDE
LFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALND
FVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQD
MLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTL
SCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTIL

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Fusion Gene PPI Analysis for USP54-PIK3CD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP54-PIK3CD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP54-PIK3CD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource