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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP6NL-ITIH5 (FusionGDB2 ID:97611)

Fusion Gene Summary for USP6NL-ITIH5

check button Fusion gene summary
Fusion gene informationFusion gene name: USP6NL-ITIH5
Fusion gene ID: 97611
HgeneTgene
Gene symbol

USP6NL

ITIH5

Gene ID

9712

80760

Gene nameUSP6 N-terminal likeinter-alpha-trypsin inhibitor heavy chain 5
SynonymsRNTRE|TRE2NL|USP6NL-IT1ITI-HC5|PP14776
Cytomap

10p14

10p14

Type of geneprotein-codingprotein-coding
DescriptionUSP6 N-terminal-like proteinrelated to the N-terminus of treinter-alpha-trypsin inhibitor heavy chain H5ITI heavy chain H5inter-alpha (globulin) inhibitor H5inter-alpha-trypsin inhibitor heavy chain family member 5
Modification date2020031320200320
UniProtAcc.

Q86UX2

Ensembl transtripts involved in fusion geneENST00000277575, ENST00000379237, 
ENST00000609104, ENST00000443016, 
ENST00000609853, 		ENST00000446830, 
ENST00000298441, ENST00000397145, 
ENST00000434980, ENST00000256861, 
ENST00000397146, 
Fusion gene scores* DoF score23 X 16 X 11=40487 X 7 X 3=147
# samples 307
** MAII scorelog2(30/4048*10)=-3.75417488419843
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP6NL [Title/Abstract] AND ITIH5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP6NL(11551594)-ITIH5(7697638), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP6NL

GO:0043547

positive regulation of GTPase activity

17562788


check buttonFusion gene breakpoints across USP6NL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITIH5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8058-01AUSP6NLchr10

11551594

-ITIH5chr10

7697638

-


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Fusion Gene ORF analysis for USP6NL-ITIH5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000277575ENST00000446830USP6NLchr10

11551594

-ITIH5chr10

7697638

-
5CDS-5UTRENST00000379237ENST00000446830USP6NLchr10

11551594

-ITIH5chr10

7697638

-
5CDS-5UTRENST00000609104ENST00000446830USP6NLchr10

11551594

-ITIH5chr10

7697638

-
5CDS-intronENST00000277575ENST00000298441USP6NLchr10

11551594

-ITIH5chr10

7697638

-
5CDS-intronENST00000277575ENST00000397145USP6NLchr10

11551594

-ITIH5chr10

7697638

-
5CDS-intronENST00000277575ENST00000434980USP6NLchr10

11551594

-ITIH5chr10

7697638

-
5CDS-intronENST00000379237ENST00000298441USP6NLchr10

11551594

-ITIH5chr10

7697638

-
5CDS-intronENST00000379237ENST00000397145USP6NLchr10

11551594

-ITIH5chr10

7697638

-
5CDS-intronENST00000379237ENST00000434980USP6NLchr10

11551594

-ITIH5chr10

7697638

-
5CDS-intronENST00000609104ENST00000298441USP6NLchr10

11551594

-ITIH5chr10

7697638

-
5CDS-intronENST00000609104ENST00000397145USP6NLchr10

11551594

-ITIH5chr10

7697638

-
5CDS-intronENST00000609104ENST00000434980USP6NLchr10

11551594

-ITIH5chr10

7697638

-
In-frameENST00000277575ENST00000256861USP6NLchr10

11551594

-ITIH5chr10

7697638

-
In-frameENST00000277575ENST00000397146USP6NLchr10

11551594

-ITIH5chr10

7697638

-
In-frameENST00000379237ENST00000256861USP6NLchr10

11551594

-ITIH5chr10

7697638

-
In-frameENST00000379237ENST00000397146USP6NLchr10

11551594

-ITIH5chr10

7697638

-
In-frameENST00000609104ENST00000256861USP6NLchr10

11551594

-ITIH5chr10

7697638

-
In-frameENST00000609104ENST00000397146USP6NLchr10

11551594

-ITIH5chr10

7697638

-
intron-3CDSENST00000443016ENST00000256861USP6NLchr10

11551594

-ITIH5chr10

7697638

-
intron-3CDSENST00000443016ENST00000397146USP6NLchr10

11551594

-ITIH5chr10

7697638

-
intron-3CDSENST00000609853ENST00000256861USP6NLchr10

11551594

-ITIH5chr10

7697638

-
intron-3CDSENST00000609853ENST00000397146USP6NLchr10

11551594

-ITIH5chr10

7697638

-
intron-5UTRENST00000443016ENST00000446830USP6NLchr10

11551594

-ITIH5chr10

7697638

-
intron-5UTRENST00000609853ENST00000446830USP6NLchr10

11551594

-ITIH5chr10

7697638

-
intron-intronENST00000443016ENST00000298441USP6NLchr10

11551594

-ITIH5chr10

7697638

-
intron-intronENST00000443016ENST00000397145USP6NLchr10

11551594

-ITIH5chr10

7697638

-
intron-intronENST00000443016ENST00000434980USP6NLchr10

11551594

-ITIH5chr10

7697638

-
intron-intronENST00000609853ENST00000298441USP6NLchr10

11551594

-ITIH5chr10

7697638

-
intron-intronENST00000609853ENST00000397145USP6NLchr10

11551594

-ITIH5chr10

7697638

-
intron-intronENST00000609853ENST00000434980USP6NLchr10

11551594

-ITIH5chr10

7697638

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000609104USP6NLchr1011551594-ENST00000256861ITIH5chr107697638-722467136534511028
ENST00000609104USP6NLchr1011551594-ENST00000397146ITIH5chr107697638-26696713652668768
ENST00000277575USP6NLchr1011551594-ENST00000256861ITIH5chr107697638-69233704331501035
ENST00000277575USP6NLchr1011551594-ENST00000397146ITIH5chr107697638-2368370432367775
ENST00000379237USP6NLchr1011551594-ENST00000256861ITIH5chr107697638-69574045931841041
ENST00000379237USP6NLchr1011551594-ENST00000397146ITIH5chr107697638-2402404592401781

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000609104ENST00000256861USP6NLchr1011551594-ITIH5chr107697638-0.0008057950.9991942
ENST00000609104ENST00000397146USP6NLchr1011551594-ITIH5chr107697638-0.008928740.99107134
ENST00000277575ENST00000256861USP6NLchr1011551594-ITIH5chr107697638-0.0004956280.9995043
ENST00000277575ENST00000397146USP6NLchr1011551594-ITIH5chr107697638-0.0074246850.9925753
ENST00000379237ENST00000256861USP6NLchr1011551594-ITIH5chr107697638-0.0005736780.99942636
ENST00000379237ENST00000397146USP6NLchr1011551594-ITIH5chr107697638-0.0056716290.99432844

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Fusion Genomic Features for USP6NL-ITIH5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP6NL-ITIH5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:11551594/chr10:7697638)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ITIH5

Q86UX2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May act as a tumor suppressor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneITIH5chr10:11551594chr10:7697638ENST00000256861014295_47830957.0DomainVWFA
TgeneITIH5chr10:11551594chr10:7697638ENST0000025686101435_16130957.0DomainVIT
TgeneITIH5chr10:11551594chr10:7697638ENST00000298441010295_4780743.0DomainVWFA
TgeneITIH5chr10:11551594chr10:7697638ENST0000029844101035_1610743.0DomainVIT

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP6NLchr10:11551594chr10:7697638ENST00000277575-514100_292109846.0DomainRab-GAP TBC
HgeneUSP6NLchr10:11551594chr10:7697638ENST00000379237-514100_292115852.0DomainRab-GAP TBC


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Fusion Gene Sequence for USP6NL-ITIH5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97611_97611_1_USP6NL-ITIH5_USP6NL_chr10_11551594_ENST00000277575_ITIH5_chr10_7697638_ENST00000256861_length(transcript)=6923nt_BP=370nt
ACTATAAAATAATAATGAAATCTTGGAATAGATAAGTTACTCTATGAGGACTGAAGCTGTTGTTAATTCCCAAGGCCAGACTGATTATCT
CACAAAGGATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGC
AGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCA
TAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAA
CACTGAAAAGGATGGACTCAGGGTCCCGAGGCAAGTCAGACTGTTGCAGAGGCTGAAAACCAAACCTTTGATGACAGAATTCTCAGTGAA
GTCTACCATCATTTCCCGTTATGCCTTCACTACGGTTTCCTGCAGAATGCTGAACAGAGCTTCTGAAGACCAGGACATTGAGTTCCAGAT
GCAGATTCCAGCTGCAGCTTTCATCACCAACTTCACTATGCTTATTGGAGACAAGGTGTATCAGGGCGAAATTACAGAGAGAGAAAAGAA
GAGTGGTGATAGGGTAAAAGAGAAAAGGAATAAAACCACAGAAGAAAATGGAGAGAAGGGGACTGAAATATTCAGAGCTTCTGCAGTGAT
TCCCAGCAAGGACAAAGCCGCCTTTTTCCTGAGTTATGAGGAGCTTCTGCAGAGGCGCCTGGGCAAGTACGAGCACAGCATCAGCGTGCG
GCCCCAGCAGCTGTCCGGGAGGCTGAGCGTGGACGTGAATATCCTGGAGAGCGCGGGCATCGCATCCCTGGAGGTGCTGCCGCTTCACAA
CAGCAGGCAGAGGGGCAGTGGGCGCGGGGAAGATGATTCTGGGCCTCCCCCATCTACTGTCATTAACCAAAATGAAACATTTGCCAACAT
AATTTTTAAACCTACTGTAGTACAACAAGCCAGGATTGCCCAGAATGGAATTTTGGGAGACTTTATCATTAGATATGACGTCAATAGAGA
ACAGAGCATTGGGGACATCCAGGTTCTAAATGGCTATTTTGTGCACTACTTTGCTCCTAAAGACCTTCCTCCTTTACCCAAGAATGTGGT
ATTCGTGCTTGACAGCAGTGCTTCTATGGTGGGAACCAAACTCCGGCAGACCAAGGATGCCCTCTTCACAATTCTCCATGACCTCCGACC
CCAGGACCGTTTCAGTATCATTGGATTTTCCAACCGGATCAAAGTATGGAAGGACCACTTGATATCAGTCACTCCAGACAGCATCAGGGA
TGGGAAAGTGTACATTCACCATATGTCACCCACTGGAGGCACAGACATCAACGGGGCCCTGCAGAGGGCCATCAGGCTCCTCAACAAGTA
CGTGGCCCACAGTGGCATTGGAGACCGGAGCGTGTCCCTCATCGTCTTCCTGACGGATGGGAAGCCCACGGTCGGGGAGACGCACACCCT
CAAGATCCTCAACAACACCCGAGAGGCCGCCCGAGGCCAAGTCTGCATCTTCACCATTGGCATCGGCAACGACGTGGACTTCAGGCTGCT
GGAGAAACTGTCGCTGGAGAACTGTGGCCTCACACGGCGCGTGCACGAGGAGGAGGACGCAGGCTCGCAGCTCATCGGGTTCTACGATGA
AATCAGGACCCCGCTCCTCTCTGACATCCGCATCGATTATCCCCCCAGCTCAGTGGTGCAGGCCACCAAGACCCTGTTCCCCAACTACTT
CAACGGCTCGGAGATCATCATTGCGGGGAAGCTGGTGGACAGGAAGCTGGATCACCTGCACGTGGAGGTCACCGCCAGCAACAGTAAGAA
ATTCATCATCCTGAAGACAGATGTGCCTGTGCGGCCTCAGAAGGCAGGGAAAGATGTCACAGGAAGCCCCAGGCCTGGAGGCGATGGAGA
GGGGGACACCAACCACATCGAGCGTCTCTGGAGCTACCTCACCACAAAGGAGCTGCTGAGCTCCTGGCTGCAAAGTGACGATGAACCGGA
GAAGGAGCGGCTGCGGCAGCGGGCCCAGGCCCTGGCTGTGAGCTACCGCTTCCTCACTCCCTTCACCTCCATGAAGCTGAGGGGGCCGGT
CCCACGCATGGATGGCCTGGAGGAGGCCCACGGCATGTCGGCTGCCATGGGACCCGAACCGGTGGTGCAGAGCGTGCGAGGAGCTGGCAC
GCAGCCAGGACCTTTGCTCAAGAAGCCATACCAGCCAAGAATTAAAATCTCTAAAACATCAGTGGATGGTGATCCCCACTTTGTTGTGGA
TTTCCCCCTGAGCAGACTCACCGTGTGCTTCAACATTGATGGGCAGCCCGGGGACATCCTCAGGCTGGTCTCTGATCACAGGGACTCTGG
TGTCACAGTGAACGGAGAGTTAATTGGGGCACCCGCCCCTCCAAATGGCCACAAGAAACAGCGCACTTACTTGCGCACTATCACCATCCT
CATCAACAAGCCAGAGAGATCTTATCTCGAGATCACACCGAGCAGAGTCATCTTGGATGGTGGGGACAGACTGGTGCTCCCCTGCAACCA
GAGTGTGGTGGTGGGGAGCTGGGGGCTGGAGGTGTCCGTGTCTGCCAACGCCAATGTCACCGTCACCATCCAGGGCTCCATAGCCTTTGT
CATCCTCATCCACCTCTACAAAAAGCCGGCGCCCTTCCAGCGACACCACCTGGGTTTCTACATTGCCAACAGCGAGGGCCTTTCCAGCAA
CTGCCACGGACTGCTGGGTCAGTTCCTGAATCAGGATGCCAGACTCACAGAAGACCCTGCAGGGCCCAGCCAGAACCTCACTCACCCTCT
GCTCCTTCAGGTGGGAGAGGGGCCTGAGGCCGTCCTAACAGTGAAAGGCCACCAAGTCCCAGTGGTCTGGAAGCAAAGGAAGATTTACAA
CGGGGAAGAGCAGATAGACTGCTGGTTTGCCAGGAACAATGCCGCCAAACTGATTGACGGGGAGTACAAGGATTACCTGGCATTCCATCC
ATTTGACACAGGGATGGACACTTGGCCGGGGAATGTCCAGGGAGCTCTGAAGCTGGCAGCCTTAAAGATGCAAGTGCATGAAGGACAGTG
ATGTGGGGAGGCCGTGGGGCAGCTCTTTTCATGGCTTGTACACGCCTCAGCTCCTGGCAATTAGCTGGACTCCATGACCCACCCCTGGTG
CAGCATAGATCCGACGTCTGTCTGGGCGAAGGGTAGGGGTGGGTAGGGGCGGGAAGCCTGAGTGCAAATGTCATTTCCCTCTACTGCCTC
TTCCTGCCTCTCCCCACCCTGCCCACATCCACAGAGGGGAGAGAAGGGTCATAGCTAAATGCAACAAAGTCTGTATCTTGTCCCAACCTG
CTTTTCTGTTCTGTTAGCATATCATAAAGTAAGCCTTTCTGGTGAAGGAAGGTTGCTATGAAACTTTTTTTCTTGGTGGAAATGGACAAG
TTTAGGCACTCTGCTTTTTGCCTTACACTAATGCTTAGAAAGCTGTCTTTTCAGTGGTGTTGCAGCCCCCAGATGTGTGGCCAACCTCTG
CTGCAAAGGAATCTCTTGCTGAGTCCAGGCCACCAATCAGGCAAATAGCCCATACATTTGATCGTTGTAAACCATGAAGTCTTTTCTTGC
AAGACGTTTTTCTTCTGCTGTGGTATCTTGCCCTTAAAAATTAGTTTTCATTAAAAAGAAATTTGATTGAAAATAGAAACATCTACAGCT
CAGATACTGATCTCTTTCTAATGGGCTTTGTAAACCACTTGACTTTGCTAATGGCTATTCTCCAATTTGTTCCAATAAGCTAAGGGCTTT
TCATACACAGGACAACTCCATGTGGTTGATTTTACTGGCATGTCTTGGTGACGAAGAGTTGGCCAAGTGAATGATGCATCTTTTACTTGG
AGCTCTCCAGCCTTTGTCATAGTTCCCAGACCTTTTTTCCTTGTGGTCATCCAGGAGGTGATCAATTACATGTGCACAGTGCTAGGACGG
GAGGCAGAGCCGGCTCAGAGCAGGTCCACCAGCCCACCTATAGCAGGAAGCGTGTCGGTGCTTAGGAAATCTAGGACTTCCAGCTTCCCT
CATGTCAGATAGAAAAAAAGTCAGGAAACCAGCTCGTGGACAGGGGCTTTGGTTCCAAAACTTGGACAAACCTGATGCCTTAAGGAAAAG
GTTAAGATGAGAGGGGACTTCCAGAGTCAATGAACGTCACCCTTCAGCGGACGGATACCGGGAGCGCTTGGGCGAAACAGCAGAGAAAGA
AAGACTGTGGTCGGGGAAGTGGAATGCTTCGATGCAGGCCAGAGTTCAAGGCTCTGGGGCTGGCCTCACAAGAGGCTTCTTCCACGGGGC
TTGACACCAGAGCAGCCCCCGCGTGAAATGAGAAGGCATGCTTAGCACTGGGAGGAAAAGCTGAGTTAAGAAAATTCTTTATCATGTTTG
CCTTCCCTGGGGAAACATTCAGGCAGTAAAATGACATCCACGTGTTCCTGTCGGACGCAGCGGCTTCGGGAACAAGTTAGCGCTGGGGGA
CTATCTGGGCTCGTCTCTCTCTGCTTCGTGAACCCACCACACCAGGGCCTGTCTGCTGTGCTATTTATTTGCCTTCCGTCTTCCCAACCT
CAGCTGCCTGTATTCATGCCAGAGGTGCAAAGGCTGCCAGCCAGTGCTGCTGACAGATGCTTTCAGACTGTAGAGCTCAGAGAAAGGGAG
CGGCAGCTAGAGGTAGCCAGGGAGCTGGCCAGGCTCCCCGGGGCCTTCCTATTATGTAAATCCCAGCTGGACAGACAGCCCTGGAGCCAG
GTGGCCCTGTCCCCTGTGGAGCACTTGGAGCAGTGATCTGTTGTTCCAGGTGTAAGTCTCGACACTGCAGAAATGAGGACGTTATTAGGA
AAGACCAGTTCCTACTGCCTGTGTTGCTACTTTAAGAGCTGAGAAAAACATTCCAATGAGCTATCCATAGCTAACTTGCTTGCTCAGAAA
AACATAAGTAACAAAGTTGAGCTTTCATTTTTAAAAATTATATTTTACTTTAGAAAAATATCACCTTTTTTCTTCCTCTTCTTTACGTGT
AGATCTTTTTTTTTTTTTTCAAATGGGGTCAGTACCTGAAAGCCCGAAACCCCATACCAAGCTTATAGTTAGGACCTTTGCATTTGATAA
AAAAAAAATATAGTATTTTCTGTTGTCCAGAAAATCTTCCCAGATAGGGAAACTGAGGCAGAGAGTGCCGTGGAGTGGTTTTTGCCAAGT
CATACAACATACTTAATGCAGGGCTACACTGAACCTCCAGAATCATTTTGTTTGCTTTGACCCTGTTTCACCATCTGGGCAATCATTTAT
TTTCCTTGAGCATTTATAAACCAGGGCGAGGGTTGTTCCAAAATGAGTAATTGAATGAGATGAAGAAATATGTCATAATTAGAGGAGATA
AATCTCCTTGTTATCACAATAGTTAATGTGTCATGATCACTGACTAACTGGGACCTTGAACAAGTCAGCATCTCTGCCTTTCAAAATGAA
GGAACATTGTTCTCTATCCTCCCCTGACCCCCGACGGCCCCATGCTAGGTGCACCATCTTCCTCCATTTGACTTTTTAATGCTTTACAAC
TTCAGGCTAAAGGGAGGGGATGTTGGGAGGAGAAACCATCACAAGATTCCCTCGGTGCCACAGCTGTGCTGAGGAGGCCGGGGACTGGGA
ATCGGAGTGGGCACCTCTGTGTTTCTCTAGGGAGTAACATTCAACATTTAATTGAATCGTGTGTCCTGATAGGTGGATTAGGAACAGGAT
TCATTCCTTTAACTTTAACTTTTGGCTAAACGACATGCCTTGGATTGAGTGTATATGTCTTCCCCAAATTCATATGTTGAAGCTTAAATC
CTGAATGTGATGGTTCTTGGAATTGGGACCTTTGGAAGGTTATTGGGTCTTGAGGGCAGAGCCCTCACGAATGGGATTAAGGCCCTTATA
AGAAGAGACATGGGGCCAGGTGCAGTGGCTCACACCTGTAATCCCAACATTTTGGGAGGCCGAGAAGGGTGGATCATGAGGTCAGGAGAT
GGAGACCATCCTGGCCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGCGTGCCTGTAGTTCCAG
CTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCAGGCAGTCGGAACTTGTAGTGAGCCAAGATCACGCCACTGCACTCCAGCTGGA
GTGACAGAGCCAAACTCCGTCAAAAAAAAACAAAACAAAACAAAAAAAAGACATGGGAGAGATGGTGTTTTTCCTCTCCACCACCTGGGG
ATACGATGAGAAGATGGCCACCTGCAAGCCAGGAAGACGGCCCTCACCAGACACCATGTCTGCTGGCACCTTGATCTTGGACCTCCCAGC
CTCCAGAACTGTGAGAAATAAATGTGTTTTGTTTAAGCTACTCAAGTCTGTGGTATTCTTGTTAAGGCAGCCCAAGCTGACTAAGACACC
AAATCATTCAAAACGTTAATTCTTTTTCTGTTCTTTAAGCTTCCCAGAATGTACACAAACAATGCTGTTATTAAAATTTAAAGGACTCTT
GGAACTGTAGGACATGATCCAGCTAAAATAAATAACAAATAACACAGCTAAGCAAATACTTATAAATGTAGCTTTAAATATTTATTTTAG
TTTTAAATAATTAGTGGGGTACGAGACAGTTCACATTCAAGAGACATTTTACTTAGACAAAAAATTTATAAGAGAACGATGCATAAAAAC

>97611_97611_1_USP6NL-ITIH5_USP6NL_chr10_11551594_ENST00000277575_ITIH5_chr10_7697638_ENST00000256861_length(amino acids)=1035AA_BP=109
MRTEAVVNSQGQTDYLTKDSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIER
TTKWLKMLKGWEKYKNTEKDGLRVPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFITNFTML
IGDKVYQGEITEREKKSGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEELLQRRLGKYEHSISVRPQQLSGRLSVDVNI
LESAGIASLEVLPLHNSRQRGSGRGEDDSGPPPSTVINQNETFANIIFKPTVVQQARIAQNGILGDFIIRYDVNREQSIGDIQVLNGYFV
HYFAPKDLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLISVTPDSIRDGKVYIHHMSPTGGT
DINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGKPTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRV
HEEEDAGSQLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLHVEVTASNSKKFIILKTDVPVRPQK
AGKDVTGSPRPGGDGEGDTNHIERLWSYLTTKELLSSWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMDGLEEAHGMSA
AMGPEPVVQSVRGAGTQPGPLLKKPYQPRIKISKTSVDGDPHFVVDFPLSRLTVCFNIDGQPGDILRLVSDHRDSGVTVNGELIGAPAPP
NGHKKQRTYLRTITILINKPERSYLEITPSRVILDGGDRLVLPCNQSVVVGSWGLEVSVSANANVTVTIQGSIAFVILIHLYKKPAPFQR
HHLGFYIANSEGLSSNCHGLLGQFLNQDARLTEDPAGPSQNLTHPLLLQVGEGPEAVLTVKGHQVPVVWKQRKIYNGEEQIDCWFARNNA

--------------------------------------------------------------
>97611_97611_2_USP6NL-ITIH5_USP6NL_chr10_11551594_ENST00000277575_ITIH5_chr10_7697638_ENST00000397146_length(transcript)=2368nt_BP=370nt
ACTATAAAATAATAATGAAATCTTGGAATAGATAAGTTACTCTATGAGGACTGAAGCTGTTGTTAATTCCCAAGGCCAGACTGATTATCT
CACAAAGGATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGC
AGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCA
TAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAA
CACTGAAAAGGATGGACTCAGGGTCCCGAGGCAAGTCAGACTGTTGCAGAGGCTGAAAACCAAACCTTTGATGACAGAATTCTCAGTGAA
GTCTACCATCATTTCCCGTTATGCCTTCACTACGGTTTCCTGCAGAATGCTGAACAGAGCTTCTGAAGACCAGGACATTGAGTTCCAGAT
GCAGATTCCAGCTGCAGCTTTCATCACCAACTTCACTATGCTTATTGGAGACAAGGTGTATCAGGGCGAAATTACAGAGAGAGAAAAGAA
GAGTGGTGATAGGGTAAAAGAGAAAAGGAATAAAACCACAGAAGAAAATGGAGAGAAGGGGACTGAAATATTCAGAGCTTCTGCAGTGAT
TCCCAGCAAGGACAAAGCCGCCTTTTTCCTGAGTTATGAGGAGCTTCTGCAGAGGCGCCTGGGCAAGTACGAGCACAGCATCAGCGTGCG
GCCCCAGCAGCTGTCCGGGAGGCTGAGCGTGGACGTGAATATCCTGGAGAGCGCGGGCATCGCATCCCTGGAGGTGCTGCCGCTTCACAA
CAGCAGGCAGAGGGGCAGTGGGCGCGGGGAAGATGATTCTGGGCCTCCCCCATCTACTGTCATTAACCAAAATGAAACATTTGCCAACAT
AATTTTTAAACCTACTGTAGTACAACAAGCCAGGATTGCCCAGAATGGAATTTTGGGAGACTTTATCATTAGATATGACGTCAATAGAGA
ACAGAGCATTGGGGACATCCAGGTTCTAAATGGCTATTTTGTGCACTACTTTGCTCCTAAAGACCTTCCTCCTTTACCCAAGAATGTGGT
ATTCGTGCTTGACAGCAGTGCTTCTATGGTGGGAACCAAACTCCGGCAGACCAAGGATGCCCTCTTCACAATTCTCCATGACCTCCGACC
CCAGGACCGTTTCAGTATCATTGGATTTTCCAACCGGATCAAAGTATGGAAGGACCACTTGATATCAGTCACTCCAGACAGCATCAGGGA
TGGGAAAGTGTACATTCACCATATGTCACCCACTGGAGGCACAGACATCAACGGGGCCCTGCAGAGGGCCATCAGGCTCCTCAACAAGTA
CGTGGCCCACAGTGGCATTGGAGACCGGAGCGTGTCCCTCATCGTCTTCCTGACGGATGGGAAGCCCACGGTCGGGGAGACGCACACCCT
CAAGATCCTCAACAACACCCGAGAGGCCGCCCGAGGCCAAGTCTGCATCTTCACCATTGGCATCGGCAACGACGTGGACTTCAGGCTGCT
GGAGAAACTGTCGCTGGAGAACTGTGGCCTCACACGGCGCGTGCACGAGGAGGAGGACGCAGGCTCGCAGCTCATCGGGTTCTACGATGA
AATCAGGACCCCGCTCCTCTCTGACATCCGCATCGATTATCCCCCCAGCTCAGTGGTGCAGGCCACCAAGACCCTGTTCCCCAACTACTT
CAACGGCTCGGAGATCATCATTGCGGGGAAGCTGGTGGACAGGAAGCTGGATCACCTGCACGTGGAGGTCACCGCCAGCAACAGTAAGAA
ATTCATCATCCTGAAGACAGATGTGCCTGTGCGGCCTCAGAAGGCAGGGAAAGATGTCACAGGAAGCCCCAGGCCTGGAGGCGATGGAGA
GGGGGACACCAACCACATCGAGCGTCTCTGGAGCTACCTCACCACAAAGGAGCTGCTGAGCTCCTGGCTGCAAAGTGACGATGAACCGGA
GAAGGAGCGGCTGCGGCAGCGGGCCCAGGCCCTGGCTGTGAGCTACCGCTTCCTCACTCCCTTCACCTCCATGAAGCTGAGGGGGCCGGT
CCCACGCATGGATGGCCTGGAGGAGGCCCACGGCATGTCGGCTGCCATGGGACCCGAACCGGTGGTGCAGAGCGTGCGAGGAGCTGGCAC
GCAGCCAGGACCTTTGCTCAAGAAGCCACCAAACTCCGTCAAAAAAAAACAAAACAAAACAAAAAAAAGACATGGGAGAGATGGTGTTTT

>97611_97611_2_USP6NL-ITIH5_USP6NL_chr10_11551594_ENST00000277575_ITIH5_chr10_7697638_ENST00000397146_length(amino acids)=775AA_BP=109
MRTEAVVNSQGQTDYLTKDSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIER
TTKWLKMLKGWEKYKNTEKDGLRVPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFITNFTML
IGDKVYQGEITEREKKSGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEELLQRRLGKYEHSISVRPQQLSGRLSVDVNI
LESAGIASLEVLPLHNSRQRGSGRGEDDSGPPPSTVINQNETFANIIFKPTVVQQARIAQNGILGDFIIRYDVNREQSIGDIQVLNGYFV
HYFAPKDLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLISVTPDSIRDGKVYIHHMSPTGGT
DINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGKPTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRV
HEEEDAGSQLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLHVEVTASNSKKFIILKTDVPVRPQK
AGKDVTGSPRPGGDGEGDTNHIERLWSYLTTKELLSSWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMDGLEEAHGMSA

--------------------------------------------------------------
>97611_97611_3_USP6NL-ITIH5_USP6NL_chr10_11551594_ENST00000379237_ITIH5_chr10_7697638_ENST00000256861_length(transcript)=6957nt_BP=404nt
GATGAAACCTGTTGGATTTCTAGAGGAAGCAGCTGGAGTCTTTGGCTTGTTAACTAGCAATGATTCAAGTCTTGCAGATTGTAAAGGAGC
TGGTGACACCATCAAGGCAAAAAGCAGCCACAGTGAAGGAAGATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAA
TAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGAT
TTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGC
TGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGGATGGACTCAGGGTCCCGAGGCAAGTCAGACTGTTGCAGAGGCTGA
AAACCAAACCTTTGATGACAGAATTCTCAGTGAAGTCTACCATCATTTCCCGTTATGCCTTCACTACGGTTTCCTGCAGAATGCTGAACA
GAGCTTCTGAAGACCAGGACATTGAGTTCCAGATGCAGATTCCAGCTGCAGCTTTCATCACCAACTTCACTATGCTTATTGGAGACAAGG
TGTATCAGGGCGAAATTACAGAGAGAGAAAAGAAGAGTGGTGATAGGGTAAAAGAGAAAAGGAATAAAACCACAGAAGAAAATGGAGAGA
AGGGGACTGAAATATTCAGAGCTTCTGCAGTGATTCCCAGCAAGGACAAAGCCGCCTTTTTCCTGAGTTATGAGGAGCTTCTGCAGAGGC
GCCTGGGCAAGTACGAGCACAGCATCAGCGTGCGGCCCCAGCAGCTGTCCGGGAGGCTGAGCGTGGACGTGAATATCCTGGAGAGCGCGG
GCATCGCATCCCTGGAGGTGCTGCCGCTTCACAACAGCAGGCAGAGGGGCAGTGGGCGCGGGGAAGATGATTCTGGGCCTCCCCCATCTA
CTGTCATTAACCAAAATGAAACATTTGCCAACATAATTTTTAAACCTACTGTAGTACAACAAGCCAGGATTGCCCAGAATGGAATTTTGG
GAGACTTTATCATTAGATATGACGTCAATAGAGAACAGAGCATTGGGGACATCCAGGTTCTAAATGGCTATTTTGTGCACTACTTTGCTC
CTAAAGACCTTCCTCCTTTACCCAAGAATGTGGTATTCGTGCTTGACAGCAGTGCTTCTATGGTGGGAACCAAACTCCGGCAGACCAAGG
ATGCCCTCTTCACAATTCTCCATGACCTCCGACCCCAGGACCGTTTCAGTATCATTGGATTTTCCAACCGGATCAAAGTATGGAAGGACC
ACTTGATATCAGTCACTCCAGACAGCATCAGGGATGGGAAAGTGTACATTCACCATATGTCACCCACTGGAGGCACAGACATCAACGGGG
CCCTGCAGAGGGCCATCAGGCTCCTCAACAAGTACGTGGCCCACAGTGGCATTGGAGACCGGAGCGTGTCCCTCATCGTCTTCCTGACGG
ATGGGAAGCCCACGGTCGGGGAGACGCACACCCTCAAGATCCTCAACAACACCCGAGAGGCCGCCCGAGGCCAAGTCTGCATCTTCACCA
TTGGCATCGGCAACGACGTGGACTTCAGGCTGCTGGAGAAACTGTCGCTGGAGAACTGTGGCCTCACACGGCGCGTGCACGAGGAGGAGG
ACGCAGGCTCGCAGCTCATCGGGTTCTACGATGAAATCAGGACCCCGCTCCTCTCTGACATCCGCATCGATTATCCCCCCAGCTCAGTGG
TGCAGGCCACCAAGACCCTGTTCCCCAACTACTTCAACGGCTCGGAGATCATCATTGCGGGGAAGCTGGTGGACAGGAAGCTGGATCACC
TGCACGTGGAGGTCACCGCCAGCAACAGTAAGAAATTCATCATCCTGAAGACAGATGTGCCTGTGCGGCCTCAGAAGGCAGGGAAAGATG
TCACAGGAAGCCCCAGGCCTGGAGGCGATGGAGAGGGGGACACCAACCACATCGAGCGTCTCTGGAGCTACCTCACCACAAAGGAGCTGC
TGAGCTCCTGGCTGCAAAGTGACGATGAACCGGAGAAGGAGCGGCTGCGGCAGCGGGCCCAGGCCCTGGCTGTGAGCTACCGCTTCCTCA
CTCCCTTCACCTCCATGAAGCTGAGGGGGCCGGTCCCACGCATGGATGGCCTGGAGGAGGCCCACGGCATGTCGGCTGCCATGGGACCCG
AACCGGTGGTGCAGAGCGTGCGAGGAGCTGGCACGCAGCCAGGACCTTTGCTCAAGAAGCCATACCAGCCAAGAATTAAAATCTCTAAAA
CATCAGTGGATGGTGATCCCCACTTTGTTGTGGATTTCCCCCTGAGCAGACTCACCGTGTGCTTCAACATTGATGGGCAGCCCGGGGACA
TCCTCAGGCTGGTCTCTGATCACAGGGACTCTGGTGTCACAGTGAACGGAGAGTTAATTGGGGCACCCGCCCCTCCAAATGGCCACAAGA
AACAGCGCACTTACTTGCGCACTATCACCATCCTCATCAACAAGCCAGAGAGATCTTATCTCGAGATCACACCGAGCAGAGTCATCTTGG
ATGGTGGGGACAGACTGGTGCTCCCCTGCAACCAGAGTGTGGTGGTGGGGAGCTGGGGGCTGGAGGTGTCCGTGTCTGCCAACGCCAATG
TCACCGTCACCATCCAGGGCTCCATAGCCTTTGTCATCCTCATCCACCTCTACAAAAAGCCGGCGCCCTTCCAGCGACACCACCTGGGTT
TCTACATTGCCAACAGCGAGGGCCTTTCCAGCAACTGCCACGGACTGCTGGGTCAGTTCCTGAATCAGGATGCCAGACTCACAGAAGACC
CTGCAGGGCCCAGCCAGAACCTCACTCACCCTCTGCTCCTTCAGGTGGGAGAGGGGCCTGAGGCCGTCCTAACAGTGAAAGGCCACCAAG
TCCCAGTGGTCTGGAAGCAAAGGAAGATTTACAACGGGGAAGAGCAGATAGACTGCTGGTTTGCCAGGAACAATGCCGCCAAACTGATTG
ACGGGGAGTACAAGGATTACCTGGCATTCCATCCATTTGACACAGGGATGGACACTTGGCCGGGGAATGTCCAGGGAGCTCTGAAGCTGG
CAGCCTTAAAGATGCAAGTGCATGAAGGACAGTGATGTGGGGAGGCCGTGGGGCAGCTCTTTTCATGGCTTGTACACGCCTCAGCTCCTG
GCAATTAGCTGGACTCCATGACCCACCCCTGGTGCAGCATAGATCCGACGTCTGTCTGGGCGAAGGGTAGGGGTGGGTAGGGGCGGGAAG
CCTGAGTGCAAATGTCATTTCCCTCTACTGCCTCTTCCTGCCTCTCCCCACCCTGCCCACATCCACAGAGGGGAGAGAAGGGTCATAGCT
AAATGCAACAAAGTCTGTATCTTGTCCCAACCTGCTTTTCTGTTCTGTTAGCATATCATAAAGTAAGCCTTTCTGGTGAAGGAAGGTTGC
TATGAAACTTTTTTTCTTGGTGGAAATGGACAAGTTTAGGCACTCTGCTTTTTGCCTTACACTAATGCTTAGAAAGCTGTCTTTTCAGTG
GTGTTGCAGCCCCCAGATGTGTGGCCAACCTCTGCTGCAAAGGAATCTCTTGCTGAGTCCAGGCCACCAATCAGGCAAATAGCCCATACA
TTTGATCGTTGTAAACCATGAAGTCTTTTCTTGCAAGACGTTTTTCTTCTGCTGTGGTATCTTGCCCTTAAAAATTAGTTTTCATTAAAA
AGAAATTTGATTGAAAATAGAAACATCTACAGCTCAGATACTGATCTCTTTCTAATGGGCTTTGTAAACCACTTGACTTTGCTAATGGCT
ATTCTCCAATTTGTTCCAATAAGCTAAGGGCTTTTCATACACAGGACAACTCCATGTGGTTGATTTTACTGGCATGTCTTGGTGACGAAG
AGTTGGCCAAGTGAATGATGCATCTTTTACTTGGAGCTCTCCAGCCTTTGTCATAGTTCCCAGACCTTTTTTCCTTGTGGTCATCCAGGA
GGTGATCAATTACATGTGCACAGTGCTAGGACGGGAGGCAGAGCCGGCTCAGAGCAGGTCCACCAGCCCACCTATAGCAGGAAGCGTGTC
GGTGCTTAGGAAATCTAGGACTTCCAGCTTCCCTCATGTCAGATAGAAAAAAAGTCAGGAAACCAGCTCGTGGACAGGGGCTTTGGTTCC
AAAACTTGGACAAACCTGATGCCTTAAGGAAAAGGTTAAGATGAGAGGGGACTTCCAGAGTCAATGAACGTCACCCTTCAGCGGACGGAT
ACCGGGAGCGCTTGGGCGAAACAGCAGAGAAAGAAAGACTGTGGTCGGGGAAGTGGAATGCTTCGATGCAGGCCAGAGTTCAAGGCTCTG
GGGCTGGCCTCACAAGAGGCTTCTTCCACGGGGCTTGACACCAGAGCAGCCCCCGCGTGAAATGAGAAGGCATGCTTAGCACTGGGAGGA
AAAGCTGAGTTAAGAAAATTCTTTATCATGTTTGCCTTCCCTGGGGAAACATTCAGGCAGTAAAATGACATCCACGTGTTCCTGTCGGAC
GCAGCGGCTTCGGGAACAAGTTAGCGCTGGGGGACTATCTGGGCTCGTCTCTCTCTGCTTCGTGAACCCACCACACCAGGGCCTGTCTGC
TGTGCTATTTATTTGCCTTCCGTCTTCCCAACCTCAGCTGCCTGTATTCATGCCAGAGGTGCAAAGGCTGCCAGCCAGTGCTGCTGACAG
ATGCTTTCAGACTGTAGAGCTCAGAGAAAGGGAGCGGCAGCTAGAGGTAGCCAGGGAGCTGGCCAGGCTCCCCGGGGCCTTCCTATTATG
TAAATCCCAGCTGGACAGACAGCCCTGGAGCCAGGTGGCCCTGTCCCCTGTGGAGCACTTGGAGCAGTGATCTGTTGTTCCAGGTGTAAG
TCTCGACACTGCAGAAATGAGGACGTTATTAGGAAAGACCAGTTCCTACTGCCTGTGTTGCTACTTTAAGAGCTGAGAAAAACATTCCAA
TGAGCTATCCATAGCTAACTTGCTTGCTCAGAAAAACATAAGTAACAAAGTTGAGCTTTCATTTTTAAAAATTATATTTTACTTTAGAAA
AATATCACCTTTTTTCTTCCTCTTCTTTACGTGTAGATCTTTTTTTTTTTTTTCAAATGGGGTCAGTACCTGAAAGCCCGAAACCCCATA
CCAAGCTTATAGTTAGGACCTTTGCATTTGATAAAAAAAAAATATAGTATTTTCTGTTGTCCAGAAAATCTTCCCAGATAGGGAAACTGA
GGCAGAGAGTGCCGTGGAGTGGTTTTTGCCAAGTCATACAACATACTTAATGCAGGGCTACACTGAACCTCCAGAATCATTTTGTTTGCT
TTGACCCTGTTTCACCATCTGGGCAATCATTTATTTTCCTTGAGCATTTATAAACCAGGGCGAGGGTTGTTCCAAAATGAGTAATTGAAT
GAGATGAAGAAATATGTCATAATTAGAGGAGATAAATCTCCTTGTTATCACAATAGTTAATGTGTCATGATCACTGACTAACTGGGACCT
TGAACAAGTCAGCATCTCTGCCTTTCAAAATGAAGGAACATTGTTCTCTATCCTCCCCTGACCCCCGACGGCCCCATGCTAGGTGCACCA
TCTTCCTCCATTTGACTTTTTAATGCTTTACAACTTCAGGCTAAAGGGAGGGGATGTTGGGAGGAGAAACCATCACAAGATTCCCTCGGT
GCCACAGCTGTGCTGAGGAGGCCGGGGACTGGGAATCGGAGTGGGCACCTCTGTGTTTCTCTAGGGAGTAACATTCAACATTTAATTGAA
TCGTGTGTCCTGATAGGTGGATTAGGAACAGGATTCATTCCTTTAACTTTAACTTTTGGCTAAACGACATGCCTTGGATTGAGTGTATAT
GTCTTCCCCAAATTCATATGTTGAAGCTTAAATCCTGAATGTGATGGTTCTTGGAATTGGGACCTTTGGAAGGTTATTGGGTCTTGAGGG
CAGAGCCCTCACGAATGGGATTAAGGCCCTTATAAGAAGAGACATGGGGCCAGGTGCAGTGGCTCACACCTGTAATCCCAACATTTTGGG
AGGCCGAGAAGGGTGGATCATGAGGTCAGGAGATGGAGACCATCCTGGCCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATT
AGCTGGGCGTGGTGGTGCGTGCCTGTAGTTCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCAGGCAGTCGGAACTTGTAG
TGAGCCAAGATCACGCCACTGCACTCCAGCTGGAGTGACAGAGCCAAACTCCGTCAAAAAAAAACAAAACAAAACAAAAAAAAGACATGG
GAGAGATGGTGTTTTTCCTCTCCACCACCTGGGGATACGATGAGAAGATGGCCACCTGCAAGCCAGGAAGACGGCCCTCACCAGACACCA
TGTCTGCTGGCACCTTGATCTTGGACCTCCCAGCCTCCAGAACTGTGAGAAATAAATGTGTTTTGTTTAAGCTACTCAAGTCTGTGGTAT
TCTTGTTAAGGCAGCCCAAGCTGACTAAGACACCAAATCATTCAAAACGTTAATTCTTTTTCTGTTCTTTAAGCTTCCCAGAATGTACAC
AAACAATGCTGTTATTAAAATTTAAAGGACTCTTGGAACTGTAGGACATGATCCAGCTAAAATAAATAACAAATAACACAGCTAAGCAAA
TACTTATAAATGTAGCTTTAAATATTTATTTTAGTTTTAAATAATTAGTGGGGTACGAGACAGTTCACATTCAAGAGACATTTTACTTAG
ACAAAAAATTTATAAGAGAACGATGCATAAAAACAAACAACATATTGGTCTGTTTATTTTTCTAAGGGAAAATGGAATTGGAGCTGTTGA

>97611_97611_3_USP6NL-ITIH5_USP6NL_chr10_11551594_ENST00000379237_ITIH5_chr10_7697638_ENST00000256861_length(amino acids)=1041AA_BP=115
MIQVLQIVKELVTPSRQKAATVKEDSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQK
HLEIERTTKWLKMLKGWEKYKNTEKDGLRVPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFI
TNFTMLIGDKVYQGEITEREKKSGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEELLQRRLGKYEHSISVRPQQLSGRL
SVDVNILESAGIASLEVLPLHNSRQRGSGRGEDDSGPPPSTVINQNETFANIIFKPTVVQQARIAQNGILGDFIIRYDVNREQSIGDIQV
LNGYFVHYFAPKDLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLISVTPDSIRDGKVYIHHM
SPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGKPTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENC
GLTRRVHEEEDAGSQLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLHVEVTASNSKKFIILKTDV
PVRPQKAGKDVTGSPRPGGDGEGDTNHIERLWSYLTTKELLSSWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMDGLEE
AHGMSAAMGPEPVVQSVRGAGTQPGPLLKKPYQPRIKISKTSVDGDPHFVVDFPLSRLTVCFNIDGQPGDILRLVSDHRDSGVTVNGELI
GAPAPPNGHKKQRTYLRTITILINKPERSYLEITPSRVILDGGDRLVLPCNQSVVVGSWGLEVSVSANANVTVTIQGSIAFVILIHLYKK
PAPFQRHHLGFYIANSEGLSSNCHGLLGQFLNQDARLTEDPAGPSQNLTHPLLLQVGEGPEAVLTVKGHQVPVVWKQRKIYNGEEQIDCW

--------------------------------------------------------------
>97611_97611_4_USP6NL-ITIH5_USP6NL_chr10_11551594_ENST00000379237_ITIH5_chr10_7697638_ENST00000397146_length(transcript)=2402nt_BP=404nt
GATGAAACCTGTTGGATTTCTAGAGGAAGCAGCTGGAGTCTTTGGCTTGTTAACTAGCAATGATTCAAGTCTTGCAGATTGTAAAGGAGC
TGGTGACACCATCAAGGCAAAAAGCAGCCACAGTGAAGGAAGATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAA
TAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGAT
TTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGC
TGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGGATGGACTCAGGGTCCCGAGGCAAGTCAGACTGTTGCAGAGGCTGA
AAACCAAACCTTTGATGACAGAATTCTCAGTGAAGTCTACCATCATTTCCCGTTATGCCTTCACTACGGTTTCCTGCAGAATGCTGAACA
GAGCTTCTGAAGACCAGGACATTGAGTTCCAGATGCAGATTCCAGCTGCAGCTTTCATCACCAACTTCACTATGCTTATTGGAGACAAGG
TGTATCAGGGCGAAATTACAGAGAGAGAAAAGAAGAGTGGTGATAGGGTAAAAGAGAAAAGGAATAAAACCACAGAAGAAAATGGAGAGA
AGGGGACTGAAATATTCAGAGCTTCTGCAGTGATTCCCAGCAAGGACAAAGCCGCCTTTTTCCTGAGTTATGAGGAGCTTCTGCAGAGGC
GCCTGGGCAAGTACGAGCACAGCATCAGCGTGCGGCCCCAGCAGCTGTCCGGGAGGCTGAGCGTGGACGTGAATATCCTGGAGAGCGCGG
GCATCGCATCCCTGGAGGTGCTGCCGCTTCACAACAGCAGGCAGAGGGGCAGTGGGCGCGGGGAAGATGATTCTGGGCCTCCCCCATCTA
CTGTCATTAACCAAAATGAAACATTTGCCAACATAATTTTTAAACCTACTGTAGTACAACAAGCCAGGATTGCCCAGAATGGAATTTTGG
GAGACTTTATCATTAGATATGACGTCAATAGAGAACAGAGCATTGGGGACATCCAGGTTCTAAATGGCTATTTTGTGCACTACTTTGCTC
CTAAAGACCTTCCTCCTTTACCCAAGAATGTGGTATTCGTGCTTGACAGCAGTGCTTCTATGGTGGGAACCAAACTCCGGCAGACCAAGG
ATGCCCTCTTCACAATTCTCCATGACCTCCGACCCCAGGACCGTTTCAGTATCATTGGATTTTCCAACCGGATCAAAGTATGGAAGGACC
ACTTGATATCAGTCACTCCAGACAGCATCAGGGATGGGAAAGTGTACATTCACCATATGTCACCCACTGGAGGCACAGACATCAACGGGG
CCCTGCAGAGGGCCATCAGGCTCCTCAACAAGTACGTGGCCCACAGTGGCATTGGAGACCGGAGCGTGTCCCTCATCGTCTTCCTGACGG
ATGGGAAGCCCACGGTCGGGGAGACGCACACCCTCAAGATCCTCAACAACACCCGAGAGGCCGCCCGAGGCCAAGTCTGCATCTTCACCA
TTGGCATCGGCAACGACGTGGACTTCAGGCTGCTGGAGAAACTGTCGCTGGAGAACTGTGGCCTCACACGGCGCGTGCACGAGGAGGAGG
ACGCAGGCTCGCAGCTCATCGGGTTCTACGATGAAATCAGGACCCCGCTCCTCTCTGACATCCGCATCGATTATCCCCCCAGCTCAGTGG
TGCAGGCCACCAAGACCCTGTTCCCCAACTACTTCAACGGCTCGGAGATCATCATTGCGGGGAAGCTGGTGGACAGGAAGCTGGATCACC
TGCACGTGGAGGTCACCGCCAGCAACAGTAAGAAATTCATCATCCTGAAGACAGATGTGCCTGTGCGGCCTCAGAAGGCAGGGAAAGATG
TCACAGGAAGCCCCAGGCCTGGAGGCGATGGAGAGGGGGACACCAACCACATCGAGCGTCTCTGGAGCTACCTCACCACAAAGGAGCTGC
TGAGCTCCTGGCTGCAAAGTGACGATGAACCGGAGAAGGAGCGGCTGCGGCAGCGGGCCCAGGCCCTGGCTGTGAGCTACCGCTTCCTCA
CTCCCTTCACCTCCATGAAGCTGAGGGGGCCGGTCCCACGCATGGATGGCCTGGAGGAGGCCCACGGCATGTCGGCTGCCATGGGACCCG
AACCGGTGGTGCAGAGCGTGCGAGGAGCTGGCACGCAGCCAGGACCTTTGCTCAAGAAGCCACCAAACTCCGTCAAAAAAAAACAAAACA

>97611_97611_4_USP6NL-ITIH5_USP6NL_chr10_11551594_ENST00000379237_ITIH5_chr10_7697638_ENST00000397146_length(amino acids)=781AA_BP=115
MIQVLQIVKELVTPSRQKAATVKEDSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQK
HLEIERTTKWLKMLKGWEKYKNTEKDGLRVPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFI
TNFTMLIGDKVYQGEITEREKKSGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEELLQRRLGKYEHSISVRPQQLSGRL
SVDVNILESAGIASLEVLPLHNSRQRGSGRGEDDSGPPPSTVINQNETFANIIFKPTVVQQARIAQNGILGDFIIRYDVNREQSIGDIQV
LNGYFVHYFAPKDLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLISVTPDSIRDGKVYIHHM
SPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGKPTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENC
GLTRRVHEEEDAGSQLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLHVEVTASNSKKFIILKTDV
PVRPQKAGKDVTGSPRPGGDGEGDTNHIERLWSYLTTKELLSSWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMDGLEE

--------------------------------------------------------------
>97611_97611_5_USP6NL-ITIH5_USP6NL_chr10_11551594_ENST00000609104_ITIH5_chr10_7697638_ENST00000256861_length(transcript)=7224nt_BP=671nt
CGGCCGCTGCGGTGACGGTTGGCGGCGGCCGGTGAGGCGGGCGGGGCCGGAGGCGCGGAGGCGGGGTCCCGGGCGAGCCGCCCTGGGAGG
CGGGGGCCGTTTCCATAGCGGCGGCAGGAGGTGTCGCGCCGGGGAACTTCCTGGTTCCCGGGCTCGGCTTCGCCGGGATCCTCTTGGAAG
GGAAACAATGGGGCGGAGGGCACTGCGGTAGCCGCCGCCGCCGCCGCGCCGCGCCGCGCCGGATCTGCTCGGCCGCCCGGGACCGCCAGC
TCTGTCCGCTGCCCACAGCCTAGCAGTCGGGACCGTACTGAGGACATGTATTCCTCTGAGAAACCTTGGACAGCAGATTTTGGTTTAATA
TCTGATTGGGACAACATTCAGACCCATTTCCAGTCATGAATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAATAG
TTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGATTTG
GCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGCTGA
AAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGGATGGACTCAGGGTCCCGAGGCAAGTCAGACTGTTGCAGAGGCTGAAAA
CCAAACCTTTGATGACAGAATTCTCAGTGAAGTCTACCATCATTTCCCGTTATGCCTTCACTACGGTTTCCTGCAGAATGCTGAACAGAG
CTTCTGAAGACCAGGACATTGAGTTCCAGATGCAGATTCCAGCTGCAGCTTTCATCACCAACTTCACTATGCTTATTGGAGACAAGGTGT
ATCAGGGCGAAATTACAGAGAGAGAAAAGAAGAGTGGTGATAGGGTAAAAGAGAAAAGGAATAAAACCACAGAAGAAAATGGAGAGAAGG
GGACTGAAATATTCAGAGCTTCTGCAGTGATTCCCAGCAAGGACAAAGCCGCCTTTTTCCTGAGTTATGAGGAGCTTCTGCAGAGGCGCC
TGGGCAAGTACGAGCACAGCATCAGCGTGCGGCCCCAGCAGCTGTCCGGGAGGCTGAGCGTGGACGTGAATATCCTGGAGAGCGCGGGCA
TCGCATCCCTGGAGGTGCTGCCGCTTCACAACAGCAGGCAGAGGGGCAGTGGGCGCGGGGAAGATGATTCTGGGCCTCCCCCATCTACTG
TCATTAACCAAAATGAAACATTTGCCAACATAATTTTTAAACCTACTGTAGTACAACAAGCCAGGATTGCCCAGAATGGAATTTTGGGAG
ACTTTATCATTAGATATGACGTCAATAGAGAACAGAGCATTGGGGACATCCAGGTTCTAAATGGCTATTTTGTGCACTACTTTGCTCCTA
AAGACCTTCCTCCTTTACCCAAGAATGTGGTATTCGTGCTTGACAGCAGTGCTTCTATGGTGGGAACCAAACTCCGGCAGACCAAGGATG
CCCTCTTCACAATTCTCCATGACCTCCGACCCCAGGACCGTTTCAGTATCATTGGATTTTCCAACCGGATCAAAGTATGGAAGGACCACT
TGATATCAGTCACTCCAGACAGCATCAGGGATGGGAAAGTGTACATTCACCATATGTCACCCACTGGAGGCACAGACATCAACGGGGCCC
TGCAGAGGGCCATCAGGCTCCTCAACAAGTACGTGGCCCACAGTGGCATTGGAGACCGGAGCGTGTCCCTCATCGTCTTCCTGACGGATG
GGAAGCCCACGGTCGGGGAGACGCACACCCTCAAGATCCTCAACAACACCCGAGAGGCCGCCCGAGGCCAAGTCTGCATCTTCACCATTG
GCATCGGCAACGACGTGGACTTCAGGCTGCTGGAGAAACTGTCGCTGGAGAACTGTGGCCTCACACGGCGCGTGCACGAGGAGGAGGACG
CAGGCTCGCAGCTCATCGGGTTCTACGATGAAATCAGGACCCCGCTCCTCTCTGACATCCGCATCGATTATCCCCCCAGCTCAGTGGTGC
AGGCCACCAAGACCCTGTTCCCCAACTACTTCAACGGCTCGGAGATCATCATTGCGGGGAAGCTGGTGGACAGGAAGCTGGATCACCTGC
ACGTGGAGGTCACCGCCAGCAACAGTAAGAAATTCATCATCCTGAAGACAGATGTGCCTGTGCGGCCTCAGAAGGCAGGGAAAGATGTCA
CAGGAAGCCCCAGGCCTGGAGGCGATGGAGAGGGGGACACCAACCACATCGAGCGTCTCTGGAGCTACCTCACCACAAAGGAGCTGCTGA
GCTCCTGGCTGCAAAGTGACGATGAACCGGAGAAGGAGCGGCTGCGGCAGCGGGCCCAGGCCCTGGCTGTGAGCTACCGCTTCCTCACTC
CCTTCACCTCCATGAAGCTGAGGGGGCCGGTCCCACGCATGGATGGCCTGGAGGAGGCCCACGGCATGTCGGCTGCCATGGGACCCGAAC
CGGTGGTGCAGAGCGTGCGAGGAGCTGGCACGCAGCCAGGACCTTTGCTCAAGAAGCCATACCAGCCAAGAATTAAAATCTCTAAAACAT
CAGTGGATGGTGATCCCCACTTTGTTGTGGATTTCCCCCTGAGCAGACTCACCGTGTGCTTCAACATTGATGGGCAGCCCGGGGACATCC
TCAGGCTGGTCTCTGATCACAGGGACTCTGGTGTCACAGTGAACGGAGAGTTAATTGGGGCACCCGCCCCTCCAAATGGCCACAAGAAAC
AGCGCACTTACTTGCGCACTATCACCATCCTCATCAACAAGCCAGAGAGATCTTATCTCGAGATCACACCGAGCAGAGTCATCTTGGATG
GTGGGGACAGACTGGTGCTCCCCTGCAACCAGAGTGTGGTGGTGGGGAGCTGGGGGCTGGAGGTGTCCGTGTCTGCCAACGCCAATGTCA
CCGTCACCATCCAGGGCTCCATAGCCTTTGTCATCCTCATCCACCTCTACAAAAAGCCGGCGCCCTTCCAGCGACACCACCTGGGTTTCT
ACATTGCCAACAGCGAGGGCCTTTCCAGCAACTGCCACGGACTGCTGGGTCAGTTCCTGAATCAGGATGCCAGACTCACAGAAGACCCTG
CAGGGCCCAGCCAGAACCTCACTCACCCTCTGCTCCTTCAGGTGGGAGAGGGGCCTGAGGCCGTCCTAACAGTGAAAGGCCACCAAGTCC
CAGTGGTCTGGAAGCAAAGGAAGATTTACAACGGGGAAGAGCAGATAGACTGCTGGTTTGCCAGGAACAATGCCGCCAAACTGATTGACG
GGGAGTACAAGGATTACCTGGCATTCCATCCATTTGACACAGGGATGGACACTTGGCCGGGGAATGTCCAGGGAGCTCTGAAGCTGGCAG
CCTTAAAGATGCAAGTGCATGAAGGACAGTGATGTGGGGAGGCCGTGGGGCAGCTCTTTTCATGGCTTGTACACGCCTCAGCTCCTGGCA
ATTAGCTGGACTCCATGACCCACCCCTGGTGCAGCATAGATCCGACGTCTGTCTGGGCGAAGGGTAGGGGTGGGTAGGGGCGGGAAGCCT
GAGTGCAAATGTCATTTCCCTCTACTGCCTCTTCCTGCCTCTCCCCACCCTGCCCACATCCACAGAGGGGAGAGAAGGGTCATAGCTAAA
TGCAACAAAGTCTGTATCTTGTCCCAACCTGCTTTTCTGTTCTGTTAGCATATCATAAAGTAAGCCTTTCTGGTGAAGGAAGGTTGCTAT
GAAACTTTTTTTCTTGGTGGAAATGGACAAGTTTAGGCACTCTGCTTTTTGCCTTACACTAATGCTTAGAAAGCTGTCTTTTCAGTGGTG
TTGCAGCCCCCAGATGTGTGGCCAACCTCTGCTGCAAAGGAATCTCTTGCTGAGTCCAGGCCACCAATCAGGCAAATAGCCCATACATTT
GATCGTTGTAAACCATGAAGTCTTTTCTTGCAAGACGTTTTTCTTCTGCTGTGGTATCTTGCCCTTAAAAATTAGTTTTCATTAAAAAGA
AATTTGATTGAAAATAGAAACATCTACAGCTCAGATACTGATCTCTTTCTAATGGGCTTTGTAAACCACTTGACTTTGCTAATGGCTATT
CTCCAATTTGTTCCAATAAGCTAAGGGCTTTTCATACACAGGACAACTCCATGTGGTTGATTTTACTGGCATGTCTTGGTGACGAAGAGT
TGGCCAAGTGAATGATGCATCTTTTACTTGGAGCTCTCCAGCCTTTGTCATAGTTCCCAGACCTTTTTTCCTTGTGGTCATCCAGGAGGT
GATCAATTACATGTGCACAGTGCTAGGACGGGAGGCAGAGCCGGCTCAGAGCAGGTCCACCAGCCCACCTATAGCAGGAAGCGTGTCGGT
GCTTAGGAAATCTAGGACTTCCAGCTTCCCTCATGTCAGATAGAAAAAAAGTCAGGAAACCAGCTCGTGGACAGGGGCTTTGGTTCCAAA
ACTTGGACAAACCTGATGCCTTAAGGAAAAGGTTAAGATGAGAGGGGACTTCCAGAGTCAATGAACGTCACCCTTCAGCGGACGGATACC
GGGAGCGCTTGGGCGAAACAGCAGAGAAAGAAAGACTGTGGTCGGGGAAGTGGAATGCTTCGATGCAGGCCAGAGTTCAAGGCTCTGGGG
CTGGCCTCACAAGAGGCTTCTTCCACGGGGCTTGACACCAGAGCAGCCCCCGCGTGAAATGAGAAGGCATGCTTAGCACTGGGAGGAAAA
GCTGAGTTAAGAAAATTCTTTATCATGTTTGCCTTCCCTGGGGAAACATTCAGGCAGTAAAATGACATCCACGTGTTCCTGTCGGACGCA
GCGGCTTCGGGAACAAGTTAGCGCTGGGGGACTATCTGGGCTCGTCTCTCTCTGCTTCGTGAACCCACCACACCAGGGCCTGTCTGCTGT
GCTATTTATTTGCCTTCCGTCTTCCCAACCTCAGCTGCCTGTATTCATGCCAGAGGTGCAAAGGCTGCCAGCCAGTGCTGCTGACAGATG
CTTTCAGACTGTAGAGCTCAGAGAAAGGGAGCGGCAGCTAGAGGTAGCCAGGGAGCTGGCCAGGCTCCCCGGGGCCTTCCTATTATGTAA
ATCCCAGCTGGACAGACAGCCCTGGAGCCAGGTGGCCCTGTCCCCTGTGGAGCACTTGGAGCAGTGATCTGTTGTTCCAGGTGTAAGTCT
CGACACTGCAGAAATGAGGACGTTATTAGGAAAGACCAGTTCCTACTGCCTGTGTTGCTACTTTAAGAGCTGAGAAAAACATTCCAATGA
GCTATCCATAGCTAACTTGCTTGCTCAGAAAAACATAAGTAACAAAGTTGAGCTTTCATTTTTAAAAATTATATTTTACTTTAGAAAAAT
ATCACCTTTTTTCTTCCTCTTCTTTACGTGTAGATCTTTTTTTTTTTTTTCAAATGGGGTCAGTACCTGAAAGCCCGAAACCCCATACCA
AGCTTATAGTTAGGACCTTTGCATTTGATAAAAAAAAAATATAGTATTTTCTGTTGTCCAGAAAATCTTCCCAGATAGGGAAACTGAGGC
AGAGAGTGCCGTGGAGTGGTTTTTGCCAAGTCATACAACATACTTAATGCAGGGCTACACTGAACCTCCAGAATCATTTTGTTTGCTTTG
ACCCTGTTTCACCATCTGGGCAATCATTTATTTTCCTTGAGCATTTATAAACCAGGGCGAGGGTTGTTCCAAAATGAGTAATTGAATGAG
ATGAAGAAATATGTCATAATTAGAGGAGATAAATCTCCTTGTTATCACAATAGTTAATGTGTCATGATCACTGACTAACTGGGACCTTGA
ACAAGTCAGCATCTCTGCCTTTCAAAATGAAGGAACATTGTTCTCTATCCTCCCCTGACCCCCGACGGCCCCATGCTAGGTGCACCATCT
TCCTCCATTTGACTTTTTAATGCTTTACAACTTCAGGCTAAAGGGAGGGGATGTTGGGAGGAGAAACCATCACAAGATTCCCTCGGTGCC
ACAGCTGTGCTGAGGAGGCCGGGGACTGGGAATCGGAGTGGGCACCTCTGTGTTTCTCTAGGGAGTAACATTCAACATTTAATTGAATCG
TGTGTCCTGATAGGTGGATTAGGAACAGGATTCATTCCTTTAACTTTAACTTTTGGCTAAACGACATGCCTTGGATTGAGTGTATATGTC
TTCCCCAAATTCATATGTTGAAGCTTAAATCCTGAATGTGATGGTTCTTGGAATTGGGACCTTTGGAAGGTTATTGGGTCTTGAGGGCAG
AGCCCTCACGAATGGGATTAAGGCCCTTATAAGAAGAGACATGGGGCCAGGTGCAGTGGCTCACACCTGTAATCCCAACATTTTGGGAGG
CCGAGAAGGGTGGATCATGAGGTCAGGAGATGGAGACCATCCTGGCCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGC
TGGGCGTGGTGGTGCGTGCCTGTAGTTCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCAGGCAGTCGGAACTTGTAGTGA
GCCAAGATCACGCCACTGCACTCCAGCTGGAGTGACAGAGCCAAACTCCGTCAAAAAAAAACAAAACAAAACAAAAAAAAGACATGGGAG
AGATGGTGTTTTTCCTCTCCACCACCTGGGGATACGATGAGAAGATGGCCACCTGCAAGCCAGGAAGACGGCCCTCACCAGACACCATGT
CTGCTGGCACCTTGATCTTGGACCTCCCAGCCTCCAGAACTGTGAGAAATAAATGTGTTTTGTTTAAGCTACTCAAGTCTGTGGTATTCT
TGTTAAGGCAGCCCAAGCTGACTAAGACACCAAATCATTCAAAACGTTAATTCTTTTTCTGTTCTTTAAGCTTCCCAGAATGTACACAAA
CAATGCTGTTATTAAAATTTAAAGGACTCTTGGAACTGTAGGACATGATCCAGCTAAAATAAATAACAAATAACACAGCTAAGCAAATAC
TTATAAATGTAGCTTTAAATATTTATTTTAGTTTTAAATAATTAGTGGGGTACGAGACAGTTCACATTCAAGAGACATTTTACTTAGACA
AAAAATTTATAAGAGAACGATGCATAAAAACAAACAACATATTGGTCTGTTTATTTTTCTAAGGGAAAATGGAATTGGAGCTGTTGAGAA

>97611_97611_5_USP6NL-ITIH5_USP6NL_chr10_11551594_ENST00000609104_ITIH5_chr10_7697638_ENST00000256861_length(amino acids)=1028AA_BP=102
MGQHSDPFPVMNSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIERTTKWLKM
LKGWEKYKNTEKDGLRVPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFITNFTMLIGDKVYQ
GEITEREKKSGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEELLQRRLGKYEHSISVRPQQLSGRLSVDVNILESAGIA
SLEVLPLHNSRQRGSGRGEDDSGPPPSTVINQNETFANIIFKPTVVQQARIAQNGILGDFIIRYDVNREQSIGDIQVLNGYFVHYFAPKD
LPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLISVTPDSIRDGKVYIHHMSPTGGTDINGALQ
RAIRLLNKYVAHSGIGDRSVSLIVFLTDGKPTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRVHEEEDAG
SQLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLHVEVTASNSKKFIILKTDVPVRPQKAGKDVTG
SPRPGGDGEGDTNHIERLWSYLTTKELLSSWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMDGLEEAHGMSAAMGPEPV
VQSVRGAGTQPGPLLKKPYQPRIKISKTSVDGDPHFVVDFPLSRLTVCFNIDGQPGDILRLVSDHRDSGVTVNGELIGAPAPPNGHKKQR
TYLRTITILINKPERSYLEITPSRVILDGGDRLVLPCNQSVVVGSWGLEVSVSANANVTVTIQGSIAFVILIHLYKKPAPFQRHHLGFYI
ANSEGLSSNCHGLLGQFLNQDARLTEDPAGPSQNLTHPLLLQVGEGPEAVLTVKGHQVPVVWKQRKIYNGEEQIDCWFARNNAAKLIDGE

--------------------------------------------------------------
>97611_97611_6_USP6NL-ITIH5_USP6NL_chr10_11551594_ENST00000609104_ITIH5_chr10_7697638_ENST00000397146_length(transcript)=2669nt_BP=671nt
CGGCCGCTGCGGTGACGGTTGGCGGCGGCCGGTGAGGCGGGCGGGGCCGGAGGCGCGGAGGCGGGGTCCCGGGCGAGCCGCCCTGGGAGG
CGGGGGCCGTTTCCATAGCGGCGGCAGGAGGTGTCGCGCCGGGGAACTTCCTGGTTCCCGGGCTCGGCTTCGCCGGGATCCTCTTGGAAG
GGAAACAATGGGGCGGAGGGCACTGCGGTAGCCGCCGCCGCCGCCGCGCCGCGCCGCGCCGGATCTGCTCGGCCGCCCGGGACCGCCAGC
TCTGTCCGCTGCCCACAGCCTAGCAGTCGGGACCGTACTGAGGACATGTATTCCTCTGAGAAACCTTGGACAGCAGATTTTGGTTTAATA
TCTGATTGGGACAACATTCAGACCCATTTCCAGTCATGAATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAATAG
TTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGATTTG
GCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGCTGA
AAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGGATGGACTCAGGGTCCCGAGGCAAGTCAGACTGTTGCAGAGGCTGAAAA
CCAAACCTTTGATGACAGAATTCTCAGTGAAGTCTACCATCATTTCCCGTTATGCCTTCACTACGGTTTCCTGCAGAATGCTGAACAGAG
CTTCTGAAGACCAGGACATTGAGTTCCAGATGCAGATTCCAGCTGCAGCTTTCATCACCAACTTCACTATGCTTATTGGAGACAAGGTGT
ATCAGGGCGAAATTACAGAGAGAGAAAAGAAGAGTGGTGATAGGGTAAAAGAGAAAAGGAATAAAACCACAGAAGAAAATGGAGAGAAGG
GGACTGAAATATTCAGAGCTTCTGCAGTGATTCCCAGCAAGGACAAAGCCGCCTTTTTCCTGAGTTATGAGGAGCTTCTGCAGAGGCGCC
TGGGCAAGTACGAGCACAGCATCAGCGTGCGGCCCCAGCAGCTGTCCGGGAGGCTGAGCGTGGACGTGAATATCCTGGAGAGCGCGGGCA
TCGCATCCCTGGAGGTGCTGCCGCTTCACAACAGCAGGCAGAGGGGCAGTGGGCGCGGGGAAGATGATTCTGGGCCTCCCCCATCTACTG
TCATTAACCAAAATGAAACATTTGCCAACATAATTTTTAAACCTACTGTAGTACAACAAGCCAGGATTGCCCAGAATGGAATTTTGGGAG
ACTTTATCATTAGATATGACGTCAATAGAGAACAGAGCATTGGGGACATCCAGGTTCTAAATGGCTATTTTGTGCACTACTTTGCTCCTA
AAGACCTTCCTCCTTTACCCAAGAATGTGGTATTCGTGCTTGACAGCAGTGCTTCTATGGTGGGAACCAAACTCCGGCAGACCAAGGATG
CCCTCTTCACAATTCTCCATGACCTCCGACCCCAGGACCGTTTCAGTATCATTGGATTTTCCAACCGGATCAAAGTATGGAAGGACCACT
TGATATCAGTCACTCCAGACAGCATCAGGGATGGGAAAGTGTACATTCACCATATGTCACCCACTGGAGGCACAGACATCAACGGGGCCC
TGCAGAGGGCCATCAGGCTCCTCAACAAGTACGTGGCCCACAGTGGCATTGGAGACCGGAGCGTGTCCCTCATCGTCTTCCTGACGGATG
GGAAGCCCACGGTCGGGGAGACGCACACCCTCAAGATCCTCAACAACACCCGAGAGGCCGCCCGAGGCCAAGTCTGCATCTTCACCATTG
GCATCGGCAACGACGTGGACTTCAGGCTGCTGGAGAAACTGTCGCTGGAGAACTGTGGCCTCACACGGCGCGTGCACGAGGAGGAGGACG
CAGGCTCGCAGCTCATCGGGTTCTACGATGAAATCAGGACCCCGCTCCTCTCTGACATCCGCATCGATTATCCCCCCAGCTCAGTGGTGC
AGGCCACCAAGACCCTGTTCCCCAACTACTTCAACGGCTCGGAGATCATCATTGCGGGGAAGCTGGTGGACAGGAAGCTGGATCACCTGC
ACGTGGAGGTCACCGCCAGCAACAGTAAGAAATTCATCATCCTGAAGACAGATGTGCCTGTGCGGCCTCAGAAGGCAGGGAAAGATGTCA
CAGGAAGCCCCAGGCCTGGAGGCGATGGAGAGGGGGACACCAACCACATCGAGCGTCTCTGGAGCTACCTCACCACAAAGGAGCTGCTGA
GCTCCTGGCTGCAAAGTGACGATGAACCGGAGAAGGAGCGGCTGCGGCAGCGGGCCCAGGCCCTGGCTGTGAGCTACCGCTTCCTCACTC
CCTTCACCTCCATGAAGCTGAGGGGGCCGGTCCCACGCATGGATGGCCTGGAGGAGGCCCACGGCATGTCGGCTGCCATGGGACCCGAAC
CGGTGGTGCAGAGCGTGCGAGGAGCTGGCACGCAGCCAGGACCTTTGCTCAAGAAGCCACCAAACTCCGTCAAAAAAAAACAAAACAAAA

>97611_97611_6_USP6NL-ITIH5_USP6NL_chr10_11551594_ENST00000609104_ITIH5_chr10_7697638_ENST00000397146_length(amino acids)=768AA_BP=102
MGQHSDPFPVMNSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIERTTKWLKM
LKGWEKYKNTEKDGLRVPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFITNFTMLIGDKVYQ
GEITEREKKSGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEELLQRRLGKYEHSISVRPQQLSGRLSVDVNILESAGIA
SLEVLPLHNSRQRGSGRGEDDSGPPPSTVINQNETFANIIFKPTVVQQARIAQNGILGDFIIRYDVNREQSIGDIQVLNGYFVHYFAPKD
LPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLISVTPDSIRDGKVYIHHMSPTGGTDINGALQ
RAIRLLNKYVAHSGIGDRSVSLIVFLTDGKPTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRVHEEEDAG
SQLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLHVEVTASNSKKFIILKTDVPVRPQKAGKDVTG
SPRPGGDGEGDTNHIERLWSYLTTKELLSSWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMDGLEEAHGMSAAMGPEPV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USP6NL-ITIH5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP6NL-ITIH5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP6NL-ITIH5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource