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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP8-TSPAN3 (FusionGDB2 ID:97647)

Fusion Gene Summary for USP8-TSPAN3

check button Fusion gene summary
Fusion gene informationFusion gene name: USP8-TSPAN3
Fusion gene ID: 97647
HgeneTgene
Gene symbol

USP8

TSPAN3

Gene ID

9101

10099

Gene nameubiquitin specific peptidase 8tetraspanin 3
SynonymsHumORF8|PITA4|SPG59|UBPYTM4-A|TM4SF8|TSPAN-3
Cytomap

15q21.2

15q24.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 8deubiquitinating enzyme 8ubiquitin isopeptidase Yubiquitin thiolesterase 8ubiquitin-specific-processing protease 8tetraspanin-3tetraspan 3tetraspan TM4SFtetraspanin TM4-Atransmembrane 4 superfamily member 8
Modification date2020032220200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000307179, ENST00000396444, 
ENST00000425032, ENST00000433963, 
ENST00000558892, 		ENST00000558394, 
ENST00000558745, ENST00000561277, 
ENST00000424443, ENST00000559494, 
ENST00000267970, ENST00000346495, 
Fusion gene scores* DoF score10 X 10 X 8=80012 X 7 X 9=756
# samples 1113
** MAII scorelog2(11/800*10)=-2.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/756*10)=-2.53987461119262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP8 [Title/Abstract] AND TSPAN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP8(50763992)-TSPAN3(77348597), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP8

GO:0070536

protein K63-linked deubiquitination

16520378

HgeneUSP8

GO:0071108

protein K48-linked deubiquitination

16520378


check buttonFusion gene breakpoints across USP8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TSPAN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6YZ-01AUSP8chr15

50763992

-TSPAN3chr15

77348597

-
ChimerDB4SARCTCGA-DX-A6YZ-01AUSP8chr15

50763992

+TSPAN3chr15

77348597

-
ChimerDB4SARCTCGA-DX-A6YZUSP8chr15

50763992

+TSPAN3chr15

77348597

-


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Fusion Gene ORF analysis for USP8-TSPAN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000307179ENST00000558394USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-5UTRENST00000307179ENST00000558745USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-5UTRENST00000307179ENST00000561277USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-5UTRENST00000396444ENST00000558394USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-5UTRENST00000396444ENST00000558745USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-5UTRENST00000396444ENST00000561277USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-5UTRENST00000425032ENST00000558394USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-5UTRENST00000425032ENST00000558745USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-5UTRENST00000425032ENST00000561277USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-5UTRENST00000433963ENST00000558394USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-5UTRENST00000433963ENST00000558745USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-5UTRENST00000433963ENST00000561277USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-intronENST00000307179ENST00000424443USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-intronENST00000307179ENST00000559494USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-intronENST00000396444ENST00000424443USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-intronENST00000396444ENST00000559494USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-intronENST00000425032ENST00000424443USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-intronENST00000425032ENST00000559494USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-intronENST00000433963ENST00000424443USP8chr15

50763992

+TSPAN3chr15

77348597

-
5CDS-intronENST00000433963ENST00000559494USP8chr15

50763992

+TSPAN3chr15

77348597

-
In-frameENST00000307179ENST00000267970USP8chr15

50763992

+TSPAN3chr15

77348597

-
In-frameENST00000307179ENST00000346495USP8chr15

50763992

+TSPAN3chr15

77348597

-
In-frameENST00000396444ENST00000267970USP8chr15

50763992

+TSPAN3chr15

77348597

-
In-frameENST00000396444ENST00000346495USP8chr15

50763992

+TSPAN3chr15

77348597

-
In-frameENST00000425032ENST00000267970USP8chr15

50763992

+TSPAN3chr15

77348597

-
In-frameENST00000425032ENST00000346495USP8chr15

50763992

+TSPAN3chr15

77348597

-
In-frameENST00000433963ENST00000267970USP8chr15

50763992

+TSPAN3chr15

77348597

-
In-frameENST00000433963ENST00000346495USP8chr15

50763992

+TSPAN3chr15

77348597

-
intron-3CDSENST00000558892ENST00000267970USP8chr15

50763992

+TSPAN3chr15

77348597

-
intron-3CDSENST00000558892ENST00000346495USP8chr15

50763992

+TSPAN3chr15

77348597

-
intron-5UTRENST00000558892ENST00000558394USP8chr15

50763992

+TSPAN3chr15

77348597

-
intron-5UTRENST00000558892ENST00000558745USP8chr15

50763992

+TSPAN3chr15

77348597

-
intron-5UTRENST00000558892ENST00000561277USP8chr15

50763992

+TSPAN3chr15

77348597

-
intron-intronENST00000558892ENST00000424443USP8chr15

50763992

+TSPAN3chr15

77348597

-
intron-intronENST00000558892ENST00000559494USP8chr15

50763992

+TSPAN3chr15

77348597

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000307179USP8chr1550763992+ENST00000267970TSPAN3chr1577348597-456410471981745515
ENST00000307179USP8chr1550763992+ENST00000346495TSPAN3chr1577348597-247610471981670490
ENST00000433963USP8chr1550763992+ENST00000267970TSPAN3chr1577348597-486613495002047515
ENST00000433963USP8chr1550763992+ENST00000346495TSPAN3chr1577348597-277813495001972490
ENST00000396444USP8chr1550763992+ENST00000267970TSPAN3chr1577348597-470411873381885515
ENST00000396444USP8chr1550763992+ENST00000346495TSPAN3chr1577348597-261611873381810490
ENST00000425032USP8chr1550763992+ENST00000267970TSPAN3chr1577348597-43288111931509438
ENST00000425032USP8chr1550763992+ENST00000346495TSPAN3chr1577348597-22408111931434413

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000307179ENST00000267970USP8chr1550763992+TSPAN3chr1577348597-0.0003620410.99963796
ENST00000307179ENST00000346495USP8chr1550763992+TSPAN3chr1577348597-0.0004481660.99955183
ENST00000433963ENST00000267970USP8chr1550763992+TSPAN3chr1577348597-0.0003786970.9996213
ENST00000433963ENST00000346495USP8chr1550763992+TSPAN3chr1577348597-0.0004571040.99954295
ENST00000396444ENST00000267970USP8chr1550763992+TSPAN3chr1577348597-0.0003658830.99963415
ENST00000396444ENST00000346495USP8chr1550763992+TSPAN3chr1577348597-0.0004366230.9995634
ENST00000425032ENST00000267970USP8chr1550763992+TSPAN3chr1577348597-0.0003661440.9996338
ENST00000425032ENST00000346495USP8chr1550763992+TSPAN3chr1577348597-0.0003708710.99962914

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Fusion Genomic Features for USP8-TSPAN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP8-TSPAN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:50763992/chr15:77348597)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP8chr15:50763992chr15:77348597ENST00000307179+82033_1162831119.0DomainNote=MIT
HgeneUSP8chr15:50763992chr15:77348597ENST00000396444+82033_1162831119.0DomainNote=MIT
HgeneUSP8chr15:50763992chr15:77348597ENST00000433963+92133_1162831119.0DomainNote=MIT
TgeneTSPAN3chr15:50763992chr15:77348597ENST0000026797007107_21221254.0Topological domainExtracellular
TgeneTSPAN3chr15:50763992chr15:77348597ENST0000026797007234_25321254.0Topological domainCytoplasmic
TgeneTSPAN3chr15:50763992chr15:77348597ENST000002679700733_5021254.0Topological domainExtracellular
TgeneTSPAN3chr15:50763992chr15:77348597ENST000002679700772_8521254.0Topological domainCytoplasmic
TgeneTSPAN3chr15:50763992chr15:77348597ENST0000034649506107_21221229.0Topological domainExtracellular
TgeneTSPAN3chr15:50763992chr15:77348597ENST0000034649506234_25321229.0Topological domainCytoplasmic
TgeneTSPAN3chr15:50763992chr15:77348597ENST000003464950633_5021229.0Topological domainExtracellular
TgeneTSPAN3chr15:50763992chr15:77348597ENST000003464950672_8521229.0Topological domainCytoplasmic
TgeneTSPAN3chr15:50763992chr15:77348597ENST0000042444306107_2120190.0Topological domainExtracellular
TgeneTSPAN3chr15:50763992chr15:77348597ENST00000424443061_110190.0Topological domainCytoplasmic
TgeneTSPAN3chr15:50763992chr15:77348597ENST0000042444306234_2530190.0Topological domainCytoplasmic
TgeneTSPAN3chr15:50763992chr15:77348597ENST000004244430633_500190.0Topological domainExtracellular
TgeneTSPAN3chr15:50763992chr15:77348597ENST000004244430672_850190.0Topological domainCytoplasmic
TgeneTSPAN3chr15:50763992chr15:77348597ENST0000026797007213_23321254.0TransmembraneHelical
TgeneTSPAN3chr15:50763992chr15:77348597ENST000002679700751_7121254.0TransmembraneHelical
TgeneTSPAN3chr15:50763992chr15:77348597ENST000002679700786_10621254.0TransmembraneHelical
TgeneTSPAN3chr15:50763992chr15:77348597ENST0000034649506213_23321229.0TransmembraneHelical
TgeneTSPAN3chr15:50763992chr15:77348597ENST000003464950651_7121229.0TransmembraneHelical
TgeneTSPAN3chr15:50763992chr15:77348597ENST000003464950686_10621229.0TransmembraneHelical
TgeneTSPAN3chr15:50763992chr15:77348597ENST000004244430612_320190.0TransmembraneHelical
TgeneTSPAN3chr15:50763992chr15:77348597ENST0000042444306213_2330190.0TransmembraneHelical
TgeneTSPAN3chr15:50763992chr15:77348597ENST000004244430651_710190.0TransmembraneHelical
TgeneTSPAN3chr15:50763992chr15:77348597ENST000004244430686_1060190.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP8chr15:50763992chr15:77348597ENST00000307179+820195_3132831119.0DomainRhodanese
HgeneUSP8chr15:50763992chr15:77348597ENST00000307179+820777_11092831119.0DomainNote=USP
HgeneUSP8chr15:50763992chr15:77348597ENST00000396444+820195_3132831119.0DomainRhodanese
HgeneUSP8chr15:50763992chr15:77348597ENST00000396444+820777_11092831119.0DomainNote=USP
HgeneUSP8chr15:50763992chr15:77348597ENST00000433963+921195_3132831119.0DomainRhodanese
HgeneUSP8chr15:50763992chr15:77348597ENST00000433963+921777_11092831119.0DomainNote=USP
HgeneUSP8chr15:50763992chr15:77348597ENST00000307179+820405_4132831119.0MotifSH3-binding
HgeneUSP8chr15:50763992chr15:77348597ENST00000396444+820405_4132831119.0MotifSH3-binding
HgeneUSP8chr15:50763992chr15:77348597ENST00000433963+921405_4132831119.0MotifSH3-binding
TgeneTSPAN3chr15:50763992chr15:77348597ENST00000267970071_1121254.0Topological domainCytoplasmic
TgeneTSPAN3chr15:50763992chr15:77348597ENST00000346495061_1121229.0Topological domainCytoplasmic
TgeneTSPAN3chr15:50763992chr15:77348597ENST000002679700712_3221254.0TransmembraneHelical
TgeneTSPAN3chr15:50763992chr15:77348597ENST000003464950612_3221229.0TransmembraneHelical


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Fusion Gene Sequence for USP8-TSPAN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97647_97647_1_USP8-TSPAN3_USP8_chr15_50763992_ENST00000307179_TSPAN3_chr15_77348597_ENST00000267970_length(transcript)=4564nt_BP=1047nt
AATGCAAATCGGGAAAAGGGGGTGAGCTGGGCTGGCTTCCGTCCTGGTAGCCAAGGCTAATTCTCCCTCGAGTTCTTGGGAGATGGGCAT
TTGGCGAGAAGGCTGGCGTTAGTGAAGCGCGCCCGGCGTCACGGAAAGAAGCACTTGTAAGGAAATATAGCATCCATTGTGAAAGTGGAA
AAGTAAAGATAATTCATCATGCCTGCTGTGGCTTCAGTTCCTAAAGAACTCTACCTCAGTTCTTCACTAAAAGACCTTAATAAGAAGACA
GAAGTTAAACCAGAGAAAATAAGCACTAAGAGTTATGTGCACAGTGCCCTGAAGATCTTTAAGACAGCAGAAGAATGCAGATTAGATCGT
GATGAGGAAAGGGCCTATGTACTATATATGAAATACGTGACTGTTTATAATCTTATCAAAAAAAGACCTGATTTCAAGCAACAGCAGGAT
TATTTCCATTCAATACTTGGACCTGGAAACATCAAAAAAGCTGTCGAAGAAGCTGAAAGACTCTCTGAAAGCCTTAAATTAAGATATGAA
GAAGCTGAAGTCCGGAAAAAACTTGAGGAAAAAGACAGGCAGGAGGAAGCACAGCGGCTACAACAAAAAAGGCAGGAAACAGGAAGAGAG
GATGGTGGCACATTGGCTAAAGGCTCTTTGGAGAATGTTTTGGATTCCAAAGACAAAACCCAAAAGAGCAATGGTGAAAAGAATGAAAAA
TGTGAGACCAAAGAGAAAGGAGCAATCACAGCAAAGGAACTATACACAATGATGACGGATAAAAACATCAGCTTGATTATAATGGATGCT
CGAAGAATGCAGGATTATCAGGATTCCTGTATTTTACATTCTCTCAGTGTTCCTGAAGAAGCCATCAGTCCAGGAGTCACTGCTAGTTGG
ATTGAAGCACACCTGCCAGATGATTCTAAAGACACATGGAAGAAGAGGGGGAATGTGGAGTATGTGGTACTTCTTGACTGGTTTAGTTCT
GCCAAAGATTTACAGATTGGAACAACTCTCCGGAGTCTGAAAGATGCACTTTTCAAGGGGGCAGCTGGCATTTTATGCTATGTGGGAGCC
TATGTCTTCATCACTTATGATGACTATGACCACTTCTTTGAAGATGTGTACACGCTCATCCCTGCTGTAGTGATCATAGCTGTAGGAGCC
CTGCTTTTCATCATTGGGCTAATTGGCTGCTGTGCCACAATCCGGGAAAGTCGCTGTGGACTTGCCACGTTTGTCATCATCCTGCTCTTG
GTTTTTGTCACAGAAGTTGTTGTAGTGGTTTTGGGATATGTTTACAGAGCAAAGGTGGAAAATGAGGTTGATCGCAGCATTCAGAAAGTG
TATAAGACCTACAATGGAACCAACCCTGATGCTGCTAGCCGGGCTATTGATTATGTACAGAGACAGCTGCATTGTTGTGGAATTCACAAC
TACTCAGACTGGGAAAATACAGATTGGTTCAAAGAAACCAAAAACCAGAGTGTCCCTCTTAGCTGCTGCAGAGAGACTGCCAGCAATTGT
AATGGCAGCCTGGCCCACCCTTCCGACCTCTATGCTGAGGGGTGTGAGGCTCTAGTAGTGAAGAAGCTACAAGAAATCATGATGCATGTG
ATCTGGGCCGCACTGGCATTTGCAGCTATTCAGCTGCTGGGCATGCTGTGTGCTTGCATCGTGTTGTGCAGAAGGAGTAGAGATCCTGCT
TACGAGCTCCTCATCACTGGCGGAACCTATGCATAGTTGACAACTCAAGCCTGAGCTTTTTGGTCTTGTTCTGATTTGGAAGGTGAATTG
AGCAGGTCTGCTGCTGTTGGCCTCTGGAGTTCATTTAGTTAAAGCACATGTACACTGGTGTTGGACAGAGCAGCTTGGCTTTTCATGTGC
CCACCTACTTACCTACTACCTGCGACTTTCTTTTTCCTTGTTCTAGCTGACTCTTCATGCCCCTAAGATTTTAAGTACGATGGTGAACGT
TCTAATTTCAGAACCAATTGCGAGTCATGTAGTGTGGTAGAATTAAAGGAGGACACGAGCCTGCTTCTGTTACCTCCAAGTGGTAACAGG
ACTGATGCCGAAATGTCACCAGGTCCTTTCAGTCTTCACAGTGGAGAACTCTTGGCCAAAGGTTTTTGCGGGGAGGAGGAGGAAACCAGC
TTTCTGGTTAAGGTTAACACCAGATGGTGCCCCTCATTGGTGTCCTTTTAAAAAATATTTACTGTAGTCCAATAAGATAGCAGCTGTACA
AAATGACTAAAATAGATTGTAGGATCATATGGCGTATATCTTGGTTCATCTTCAAAATCAGAGACTGAGCTTTGAAACTAGTGGTTTTTA
ATCAAAGTTGGCTTTATAGGAGGAGTATAATGTATGCACTACTGTTTTAAAAGAATTAGTGTGAGTGTGTTTTTGTATGAATGAGCCCAT
TCATGGTAAGTCTTAAGCTTGTTGGAAATAATGTACCCATGTAGACTAGCAAAATAGTATGTAGATGTGATCTCAGTTGTAAATAGAAAA
ATCTAATTCAATAAACTCTGTATCAGCCCCCAACATATTATTTTTCATTATTTGGGGGATATTTCAGTTCCAGAGCAGCAGTATCATGTT
TTCTTTGTTGGTGCTGTCTATAGTTCATCATGGTTTACGTGTGTTTTCGTTATAGCTGTTGCCAGATTCTAAAGGGCTTGATATTCAAAA
AACCACAGATGCTTTCAGTCCAGTATATCCTAGAAATATAGAGCTCTACTTTGTGCAATGCACTGGGGATACAGTGGCGATACTGTCCTT
GTCTTCAAGGAGTTCGGAGTCCTAGTATAGGAGACATACATAGGAGAAGATAATTTTCACACTGCAGTGGTTGTAGTAATAGAATGGGAG
TCCAAAGGGGAGTTCCGGAGAGGTCAGGGGTGACTTCCTGGAGGAGATGCCCAAGCTTGGAGGCTGGATAGGCTTTGTTGAAAGATGGTA
CACAAGAGTGTGAAACAAAATTGTGTGTGCAGGGAGCTTAAAATACAAGGCTGGGGAAAGAAGTTGGAGAAGCAGGAAAGCCCAGGCCCT
CTAGTGTCTTACGGAACATCCTGTGGAGGTGAGAGCTGACTTGTAGGTGGAAGCAGCTCTTTGGAGGTTTGATTTGGAAGGTGAACTGAG
AAGAAGGTGGTGATGCAAGCCGGCCGTGCTGAAGCCAGGATGAATTGGTGTGACTGGGCTTCAGTTAGGCTGGCATAGCAGTTGAGAGAG
CTTAGCAGTGGGCAGCAGGGCACTGTTGGGGGCGGTGGTGAGCGGTGGATTCTGGCTGTTTGGAGGCAGGACAGTGGTGGAATTCGATCA
TTGATTGGACGTGGGACAGAGAAGGGAGAAGAGAAGACTCATCTAGGATGAGTCCCAGGTTTCTGGCTCAGTCAACTGGGGAAACAAAGT
CACAGAGCTAGGGAGTAGTTAGAGAACACATCTGGGGGTGTGACTCATGGTCAGTTTTGGGCTCGTCAGTTTTGAGATGCCCAAATATCA
TGCAGATCTGTCCCACCTGAAAATGGAGAAGACACGGGAAAGGAGAGGAGTAAAAACTAACTCCTTTTCACAAAGTGGAAGTTACCAGAA
TGTGATTTCAGAGGCCCCGGGGGATTTATCATGTGACTACTGACCCATCCCACCTCTTGCCCCTGCCTGTTGCACAGTGGGCAAGAATGT
TTGTGACCTTTCACTACCACCACCTCCCCCGAGCATGGTCCCCCCAGTTTTCAATATGAACCATCCTGTGGGTACCCTGTCACAGGCTGG
CCCTGAGGTGAGCAATATTTGGACTGTGATGTTGGTTGTTCTCCACTCTTTCTACAGGACAGAACAGGGCCTCTAGAGTGGGAAATGGCT
TTGGGAAATATGCCAAGCAGTAGCCTTGTTCTTCAACTTGCCCAAGAGGATAATTCTCCACACCCTTCCTGTACTCAGTCCTCAGTTTGC
CTGGTGAGAGAGCAGCCTCCTCCCGTGTGCTCTGCCAGCTGGACCCAGACTGGCCATATTACCAGTGAGACCAAAAAGATGGAGGTGGGG
AGGTAGCTCTGAGGTCTGGGAAACCATTCCAGCTCCTGCCAGTTTTAACTTGTGTTTAATTCCTGGCACAGTTGTCCTGGAAATGCCTTT
TTCTCTTGCCTGGGAACCACTAGAAGGGGATGTTGTCTGTGTTGGCCAGGGCCATGCAAATTCAACATCTTGTTTCTGCCCTTCCCCCGT
GTAGCTGAGGCTAGGTGTTGGCATTACCCAGTGCTTGTTCTTCAGAGAGCAAAAGCACTGCTCGTCATGTCTGAAATTTAGTGAGTGAGC
TCACCCACTAGGCTGGTGTTTCCTGCCCGTGGCTGCACATTGGAAGCACCGGGGCACTTTGAGAACTACAGATGCCTGGGTCCCAGAGCA
TCTAAGGTGCTCTAGGGTGTGTCCAGGACACAGCCCTGGTTGAGGACCACTGCTATATTGTATGGCCTCTTTTAAAAAAGTTAATTTTAC

>97647_97647_1_USP8-TSPAN3_USP8_chr15_50763992_ENST00000307179_TSPAN3_chr15_77348597_ENST00000267970_length(amino acids)=515AA_BP=283
MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSIL
GPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK
GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQI
GTTLRSLKDALFKGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEV
VVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASNCNGSLAH

--------------------------------------------------------------
>97647_97647_2_USP8-TSPAN3_USP8_chr15_50763992_ENST00000307179_TSPAN3_chr15_77348597_ENST00000346495_length(transcript)=2476nt_BP=1047nt
AATGCAAATCGGGAAAAGGGGGTGAGCTGGGCTGGCTTCCGTCCTGGTAGCCAAGGCTAATTCTCCCTCGAGTTCTTGGGAGATGGGCAT
TTGGCGAGAAGGCTGGCGTTAGTGAAGCGCGCCCGGCGTCACGGAAAGAAGCACTTGTAAGGAAATATAGCATCCATTGTGAAAGTGGAA
AAGTAAAGATAATTCATCATGCCTGCTGTGGCTTCAGTTCCTAAAGAACTCTACCTCAGTTCTTCACTAAAAGACCTTAATAAGAAGACA
GAAGTTAAACCAGAGAAAATAAGCACTAAGAGTTATGTGCACAGTGCCCTGAAGATCTTTAAGACAGCAGAAGAATGCAGATTAGATCGT
GATGAGGAAAGGGCCTATGTACTATATATGAAATACGTGACTGTTTATAATCTTATCAAAAAAAGACCTGATTTCAAGCAACAGCAGGAT
TATTTCCATTCAATACTTGGACCTGGAAACATCAAAAAAGCTGTCGAAGAAGCTGAAAGACTCTCTGAAAGCCTTAAATTAAGATATGAA
GAAGCTGAAGTCCGGAAAAAACTTGAGGAAAAAGACAGGCAGGAGGAAGCACAGCGGCTACAACAAAAAAGGCAGGAAACAGGAAGAGAG
GATGGTGGCACATTGGCTAAAGGCTCTTTGGAGAATGTTTTGGATTCCAAAGACAAAACCCAAAAGAGCAATGGTGAAAAGAATGAAAAA
TGTGAGACCAAAGAGAAAGGAGCAATCACAGCAAAGGAACTATACACAATGATGACGGATAAAAACATCAGCTTGATTATAATGGATGCT
CGAAGAATGCAGGATTATCAGGATTCCTGTATTTTACATTCTCTCAGTGTTCCTGAAGAAGCCATCAGTCCAGGAGTCACTGCTAGTTGG
ATTGAAGCACACCTGCCAGATGATTCTAAAGACACATGGAAGAAGAGGGGGAATGTGGAGTATGTGGTACTTCTTGACTGGTTTAGTTCT
GCCAAAGATTTACAGATTGGAACAACTCTCCGGAGTCTGAAAGATGCACTTTTCAAGGGGGCAGCTGGCATTTTATGCTATGTGGGAGCC
TATGTCTTCATCACTTATGATGACTATGACCACTTCTTTGAAGATGTGTACACGCTCATCCCTGCTGTAGTGATCATAGCTGTAGGAGCC
CTGCTTTTCATCATTGGGCTAATTGGCTGCTGTGCCACAATCCGGGAAAGTCGCTGTGGACTTGCCACGGTGGAAAATGAGGTTGATCGC
AGCATTCAGAAAGTGTATAAGACCTACAATGGAACCAACCCTGATGCTGCTAGCCGGGCTATTGATTATGTACAGAGACAGCTGCATTGT
TGTGGAATTCACAACTACTCAGACTGGGAAAATACAGATTGGTTCAAAGAAACCAAAAACCAGAGTGTCCCTCTTAGCTGCTGCAGAGAG
ACTGCCAGCAATTGTAATGGCAGCCTGGCCCACCCTTCCGACCTCTATGCTGAGGGGTGTGAGGCTCTAGTAGTGAAGAAGCTACAAGAA
ATCATGATGCATGTGATCTGGGCCGCACTGGCATTTGCAGCTATTCAGCTGCTGGGCATGCTGTGTGCTTGCATCGTGTTGTGCAGAAGG
AGTAGAGATCCTGCTTACGAGCTCCTCATCACTGGCGGAACCTATGCATAGTTGACAACTCAAGCCTGAGCTTTTTGGTCTTGTTCTGAT
TTGGAAGGTGAATTGAGCAGGTCTGCTGCTGTTGGCCTCTGGAGTTCATTTAGTTAAAGCACATGTACACTGGTGTTGGACAGAGCAGCT
TGGCTTTTCATGTGCCCACCTACTTACCTACTACCTGCGACTTTCTTTTTCCTTGTTCTAGCTGACTCTTCATGCCCCTAAGATTTTAAG
TACGATGGTGAACGTTCTAATTTCAGAACCAATTGCGAGTCATGTAGTGTGGTAGAATTAAAGGAGGACACGAGCCTGCTTCTGTTACCT
CCAAGTGGTAACAGGACTGATGCCGAAATGTCACCAGGTCCTTTCAGTCTTCACAGTGGAGAACTCTTGGCCAAAGGTTTTTGCGGGGAG
GAGGAGGAAACCAGCTTTCTGGTTAAGGTTAACACCAGATGGTGCCCCTCATTGGTGTCCTTTTAAAAAATATTTACTGTAGTCCAATAA
GATAGCAGCTGTACAAAATGACTAAAATAGATTGTAGGATCATATGGCGTATATCTTGGTTCATCTTCAAAATCAGAGACTGAGCTTTGA
AACTAGTGGTTTTTAATCAAAGTTGGCTTTATAGGAGGAGTATAATGTATGCACTACTGTTTTAAAAGAATTAGTGTGAGTGTGTTTTTG
TATGAATGAGCCCATTCATGGTAAGTCTTAAGCTTGTTGGAAATAATGTACCCATGTAGACTAGCAAAATAGTATGTAGATGTGATCTCA

>97647_97647_2_USP8-TSPAN3_USP8_chr15_50763992_ENST00000307179_TSPAN3_chr15_77348597_ENST00000346495_length(amino acids)=490AA_BP=283
MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSIL
GPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK
GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQI
GTTLRSLKDALFKGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLATVENEVDRSIQKVY
KTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASNCNGSLAHPSDLYAEGCEALVVKKLQEIMMHVI

--------------------------------------------------------------
>97647_97647_3_USP8-TSPAN3_USP8_chr15_50763992_ENST00000396444_TSPAN3_chr15_77348597_ENST00000267970_length(transcript)=4704nt_BP=1187nt
AATGCAAATCGGGAAAAGGGGGTGAGCTGGGCTGGCTTCCGTCCTGGTAGCCAAGGCTAATTCTCCCTCGAGTTCTTGGGAGATGGGCAT
TTGGCGAGAAGGCTGGCGTTAGTGAAGCGCGCCCGGCGTCACGGTGAGTGCGGGTCTTGGGCCCTAGCACCTGTTCTCTGGGAAGTCGTC
CGCTGTGAACGATGAACGCCTTTCCTTCCACCAGCTGCTGGTTACCCCGGAGACAAGCTCTGTCCGCGGAGAGGAGTGGGACAACTCCTA
AAGGAAAGAAGCACTTGTAAGGAAATATAGCATCCATTGTGAAAGTGGAAAAGTAAAGATAATTCATCATGCCTGCTGTGGCTTCAGTTC
CTAAAGAACTCTACCTCAGTTCTTCACTAAAAGACCTTAATAAGAAGACAGAAGTTAAACCAGAGAAAATAAGCACTAAGAGTTATGTGC
ACAGTGCCCTGAAGATCTTTAAGACAGCAGAAGAATGCAGATTAGATCGTGATGAGGAAAGGGCCTATGTACTATATATGAAATACGTGA
CTGTTTATAATCTTATCAAAAAAAGACCTGATTTCAAGCAACAGCAGGATTATTTCCATTCAATACTTGGACCTGGAAACATCAAAAAAG
CTGTCGAAGAAGCTGAAAGACTCTCTGAAAGCCTTAAATTAAGATATGAAGAAGCTGAAGTCCGGAAAAAACTTGAGGAAAAAGACAGGC
AGGAGGAAGCACAGCGGCTACAACAAAAAAGGCAGGAAACAGGAAGAGAGGATGGTGGCACATTGGCTAAAGGCTCTTTGGAGAATGTTT
TGGATTCCAAAGACAAAACCCAAAAGAGCAATGGTGAAAAGAATGAAAAATGTGAGACCAAAGAGAAAGGAGCAATCACAGCAAAGGAAC
TATACACAATGATGACGGATAAAAACATCAGCTTGATTATAATGGATGCTCGAAGAATGCAGGATTATCAGGATTCCTGTATTTTACATT
CTCTCAGTGTTCCTGAAGAAGCCATCAGTCCAGGAGTCACTGCTAGTTGGATTGAAGCACACCTGCCAGATGATTCTAAAGACACATGGA
AGAAGAGGGGGAATGTGGAGTATGTGGTACTTCTTGACTGGTTTAGTTCTGCCAAAGATTTACAGATTGGAACAACTCTCCGGAGTCTGA
AAGATGCACTTTTCAAGGGGGCAGCTGGCATTTTATGCTATGTGGGAGCCTATGTCTTCATCACTTATGATGACTATGACCACTTCTTTG
AAGATGTGTACACGCTCATCCCTGCTGTAGTGATCATAGCTGTAGGAGCCCTGCTTTTCATCATTGGGCTAATTGGCTGCTGTGCCACAA
TCCGGGAAAGTCGCTGTGGACTTGCCACGTTTGTCATCATCCTGCTCTTGGTTTTTGTCACAGAAGTTGTTGTAGTGGTTTTGGGATATG
TTTACAGAGCAAAGGTGGAAAATGAGGTTGATCGCAGCATTCAGAAAGTGTATAAGACCTACAATGGAACCAACCCTGATGCTGCTAGCC
GGGCTATTGATTATGTACAGAGACAGCTGCATTGTTGTGGAATTCACAACTACTCAGACTGGGAAAATACAGATTGGTTCAAAGAAACCA
AAAACCAGAGTGTCCCTCTTAGCTGCTGCAGAGAGACTGCCAGCAATTGTAATGGCAGCCTGGCCCACCCTTCCGACCTCTATGCTGAGG
GGTGTGAGGCTCTAGTAGTGAAGAAGCTACAAGAAATCATGATGCATGTGATCTGGGCCGCACTGGCATTTGCAGCTATTCAGCTGCTGG
GCATGCTGTGTGCTTGCATCGTGTTGTGCAGAAGGAGTAGAGATCCTGCTTACGAGCTCCTCATCACTGGCGGAACCTATGCATAGTTGA
CAACTCAAGCCTGAGCTTTTTGGTCTTGTTCTGATTTGGAAGGTGAATTGAGCAGGTCTGCTGCTGTTGGCCTCTGGAGTTCATTTAGTT
AAAGCACATGTACACTGGTGTTGGACAGAGCAGCTTGGCTTTTCATGTGCCCACCTACTTACCTACTACCTGCGACTTTCTTTTTCCTTG
TTCTAGCTGACTCTTCATGCCCCTAAGATTTTAAGTACGATGGTGAACGTTCTAATTTCAGAACCAATTGCGAGTCATGTAGTGTGGTAG
AATTAAAGGAGGACACGAGCCTGCTTCTGTTACCTCCAAGTGGTAACAGGACTGATGCCGAAATGTCACCAGGTCCTTTCAGTCTTCACA
GTGGAGAACTCTTGGCCAAAGGTTTTTGCGGGGAGGAGGAGGAAACCAGCTTTCTGGTTAAGGTTAACACCAGATGGTGCCCCTCATTGG
TGTCCTTTTAAAAAATATTTACTGTAGTCCAATAAGATAGCAGCTGTACAAAATGACTAAAATAGATTGTAGGATCATATGGCGTATATC
TTGGTTCATCTTCAAAATCAGAGACTGAGCTTTGAAACTAGTGGTTTTTAATCAAAGTTGGCTTTATAGGAGGAGTATAATGTATGCACT
ACTGTTTTAAAAGAATTAGTGTGAGTGTGTTTTTGTATGAATGAGCCCATTCATGGTAAGTCTTAAGCTTGTTGGAAATAATGTACCCAT
GTAGACTAGCAAAATAGTATGTAGATGTGATCTCAGTTGTAAATAGAAAAATCTAATTCAATAAACTCTGTATCAGCCCCCAACATATTA
TTTTTCATTATTTGGGGGATATTTCAGTTCCAGAGCAGCAGTATCATGTTTTCTTTGTTGGTGCTGTCTATAGTTCATCATGGTTTACGT
GTGTTTTCGTTATAGCTGTTGCCAGATTCTAAAGGGCTTGATATTCAAAAAACCACAGATGCTTTCAGTCCAGTATATCCTAGAAATATA
GAGCTCTACTTTGTGCAATGCACTGGGGATACAGTGGCGATACTGTCCTTGTCTTCAAGGAGTTCGGAGTCCTAGTATAGGAGACATACA
TAGGAGAAGATAATTTTCACACTGCAGTGGTTGTAGTAATAGAATGGGAGTCCAAAGGGGAGTTCCGGAGAGGTCAGGGGTGACTTCCTG
GAGGAGATGCCCAAGCTTGGAGGCTGGATAGGCTTTGTTGAAAGATGGTACACAAGAGTGTGAAACAAAATTGTGTGTGCAGGGAGCTTA
AAATACAAGGCTGGGGAAAGAAGTTGGAGAAGCAGGAAAGCCCAGGCCCTCTAGTGTCTTACGGAACATCCTGTGGAGGTGAGAGCTGAC
TTGTAGGTGGAAGCAGCTCTTTGGAGGTTTGATTTGGAAGGTGAACTGAGAAGAAGGTGGTGATGCAAGCCGGCCGTGCTGAAGCCAGGA
TGAATTGGTGTGACTGGGCTTCAGTTAGGCTGGCATAGCAGTTGAGAGAGCTTAGCAGTGGGCAGCAGGGCACTGTTGGGGGCGGTGGTG
AGCGGTGGATTCTGGCTGTTTGGAGGCAGGACAGTGGTGGAATTCGATCATTGATTGGACGTGGGACAGAGAAGGGAGAAGAGAAGACTC
ATCTAGGATGAGTCCCAGGTTTCTGGCTCAGTCAACTGGGGAAACAAAGTCACAGAGCTAGGGAGTAGTTAGAGAACACATCTGGGGGTG
TGACTCATGGTCAGTTTTGGGCTCGTCAGTTTTGAGATGCCCAAATATCATGCAGATCTGTCCCACCTGAAAATGGAGAAGACACGGGAA
AGGAGAGGAGTAAAAACTAACTCCTTTTCACAAAGTGGAAGTTACCAGAATGTGATTTCAGAGGCCCCGGGGGATTTATCATGTGACTAC
TGACCCATCCCACCTCTTGCCCCTGCCTGTTGCACAGTGGGCAAGAATGTTTGTGACCTTTCACTACCACCACCTCCCCCGAGCATGGTC
CCCCCAGTTTTCAATATGAACCATCCTGTGGGTACCCTGTCACAGGCTGGCCCTGAGGTGAGCAATATTTGGACTGTGATGTTGGTTGTT
CTCCACTCTTTCTACAGGACAGAACAGGGCCTCTAGAGTGGGAAATGGCTTTGGGAAATATGCCAAGCAGTAGCCTTGTTCTTCAACTTG
CCCAAGAGGATAATTCTCCACACCCTTCCTGTACTCAGTCCTCAGTTTGCCTGGTGAGAGAGCAGCCTCCTCCCGTGTGCTCTGCCAGCT
GGACCCAGACTGGCCATATTACCAGTGAGACCAAAAAGATGGAGGTGGGGAGGTAGCTCTGAGGTCTGGGAAACCATTCCAGCTCCTGCC
AGTTTTAACTTGTGTTTAATTCCTGGCACAGTTGTCCTGGAAATGCCTTTTTCTCTTGCCTGGGAACCACTAGAAGGGGATGTTGTCTGT
GTTGGCCAGGGCCATGCAAATTCAACATCTTGTTTCTGCCCTTCCCCCGTGTAGCTGAGGCTAGGTGTTGGCATTACCCAGTGCTTGTTC
TTCAGAGAGCAAAAGCACTGCTCGTCATGTCTGAAATTTAGTGAGTGAGCTCACCCACTAGGCTGGTGTTTCCTGCCCGTGGCTGCACAT
TGGAAGCACCGGGGCACTTTGAGAACTACAGATGCCTGGGTCCCAGAGCATCTAAGGTGCTCTAGGGTGTGTCCAGGACACAGCCCTGGT
TGAGGACCACTGCTATATTGTATGGCCTCTTTTAAAAAAGTTAATTTTACTTGGAAATGATTTCAAAGCTACAGAAAAGTTGCAAGAATA

>97647_97647_3_USP8-TSPAN3_USP8_chr15_50763992_ENST00000396444_TSPAN3_chr15_77348597_ENST00000267970_length(amino acids)=515AA_BP=283
MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSIL
GPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK
GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQI
GTTLRSLKDALFKGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEV
VVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASNCNGSLAH

--------------------------------------------------------------
>97647_97647_4_USP8-TSPAN3_USP8_chr15_50763992_ENST00000396444_TSPAN3_chr15_77348597_ENST00000346495_length(transcript)=2616nt_BP=1187nt
AATGCAAATCGGGAAAAGGGGGTGAGCTGGGCTGGCTTCCGTCCTGGTAGCCAAGGCTAATTCTCCCTCGAGTTCTTGGGAGATGGGCAT
TTGGCGAGAAGGCTGGCGTTAGTGAAGCGCGCCCGGCGTCACGGTGAGTGCGGGTCTTGGGCCCTAGCACCTGTTCTCTGGGAAGTCGTC
CGCTGTGAACGATGAACGCCTTTCCTTCCACCAGCTGCTGGTTACCCCGGAGACAAGCTCTGTCCGCGGAGAGGAGTGGGACAACTCCTA
AAGGAAAGAAGCACTTGTAAGGAAATATAGCATCCATTGTGAAAGTGGAAAAGTAAAGATAATTCATCATGCCTGCTGTGGCTTCAGTTC
CTAAAGAACTCTACCTCAGTTCTTCACTAAAAGACCTTAATAAGAAGACAGAAGTTAAACCAGAGAAAATAAGCACTAAGAGTTATGTGC
ACAGTGCCCTGAAGATCTTTAAGACAGCAGAAGAATGCAGATTAGATCGTGATGAGGAAAGGGCCTATGTACTATATATGAAATACGTGA
CTGTTTATAATCTTATCAAAAAAAGACCTGATTTCAAGCAACAGCAGGATTATTTCCATTCAATACTTGGACCTGGAAACATCAAAAAAG
CTGTCGAAGAAGCTGAAAGACTCTCTGAAAGCCTTAAATTAAGATATGAAGAAGCTGAAGTCCGGAAAAAACTTGAGGAAAAAGACAGGC
AGGAGGAAGCACAGCGGCTACAACAAAAAAGGCAGGAAACAGGAAGAGAGGATGGTGGCACATTGGCTAAAGGCTCTTTGGAGAATGTTT
TGGATTCCAAAGACAAAACCCAAAAGAGCAATGGTGAAAAGAATGAAAAATGTGAGACCAAAGAGAAAGGAGCAATCACAGCAAAGGAAC
TATACACAATGATGACGGATAAAAACATCAGCTTGATTATAATGGATGCTCGAAGAATGCAGGATTATCAGGATTCCTGTATTTTACATT
CTCTCAGTGTTCCTGAAGAAGCCATCAGTCCAGGAGTCACTGCTAGTTGGATTGAAGCACACCTGCCAGATGATTCTAAAGACACATGGA
AGAAGAGGGGGAATGTGGAGTATGTGGTACTTCTTGACTGGTTTAGTTCTGCCAAAGATTTACAGATTGGAACAACTCTCCGGAGTCTGA
AAGATGCACTTTTCAAGGGGGCAGCTGGCATTTTATGCTATGTGGGAGCCTATGTCTTCATCACTTATGATGACTATGACCACTTCTTTG
AAGATGTGTACACGCTCATCCCTGCTGTAGTGATCATAGCTGTAGGAGCCCTGCTTTTCATCATTGGGCTAATTGGCTGCTGTGCCACAA
TCCGGGAAAGTCGCTGTGGACTTGCCACGGTGGAAAATGAGGTTGATCGCAGCATTCAGAAAGTGTATAAGACCTACAATGGAACCAACC
CTGATGCTGCTAGCCGGGCTATTGATTATGTACAGAGACAGCTGCATTGTTGTGGAATTCACAACTACTCAGACTGGGAAAATACAGATT
GGTTCAAAGAAACCAAAAACCAGAGTGTCCCTCTTAGCTGCTGCAGAGAGACTGCCAGCAATTGTAATGGCAGCCTGGCCCACCCTTCCG
ACCTCTATGCTGAGGGGTGTGAGGCTCTAGTAGTGAAGAAGCTACAAGAAATCATGATGCATGTGATCTGGGCCGCACTGGCATTTGCAG
CTATTCAGCTGCTGGGCATGCTGTGTGCTTGCATCGTGTTGTGCAGAAGGAGTAGAGATCCTGCTTACGAGCTCCTCATCACTGGCGGAA
CCTATGCATAGTTGACAACTCAAGCCTGAGCTTTTTGGTCTTGTTCTGATTTGGAAGGTGAATTGAGCAGGTCTGCTGCTGTTGGCCTCT
GGAGTTCATTTAGTTAAAGCACATGTACACTGGTGTTGGACAGAGCAGCTTGGCTTTTCATGTGCCCACCTACTTACCTACTACCTGCGA
CTTTCTTTTTCCTTGTTCTAGCTGACTCTTCATGCCCCTAAGATTTTAAGTACGATGGTGAACGTTCTAATTTCAGAACCAATTGCGAGT
CATGTAGTGTGGTAGAATTAAAGGAGGACACGAGCCTGCTTCTGTTACCTCCAAGTGGTAACAGGACTGATGCCGAAATGTCACCAGGTC
CTTTCAGTCTTCACAGTGGAGAACTCTTGGCCAAAGGTTTTTGCGGGGAGGAGGAGGAAACCAGCTTTCTGGTTAAGGTTAACACCAGAT
GGTGCCCCTCATTGGTGTCCTTTTAAAAAATATTTACTGTAGTCCAATAAGATAGCAGCTGTACAAAATGACTAAAATAGATTGTAGGAT
CATATGGCGTATATCTTGGTTCATCTTCAAAATCAGAGACTGAGCTTTGAAACTAGTGGTTTTTAATCAAAGTTGGCTTTATAGGAGGAG
TATAATGTATGCACTACTGTTTTAAAAGAATTAGTGTGAGTGTGTTTTTGTATGAATGAGCCCATTCATGGTAAGTCTTAAGCTTGTTGG
AAATAATGTACCCATGTAGACTAGCAAAATAGTATGTAGATGTGATCTCAGTTGTAAATAGAAAAATCTAATTCAATAAACTCTGTATCA

>97647_97647_4_USP8-TSPAN3_USP8_chr15_50763992_ENST00000396444_TSPAN3_chr15_77348597_ENST00000346495_length(amino acids)=490AA_BP=283
MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSIL
GPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK
GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQI
GTTLRSLKDALFKGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLATVENEVDRSIQKVY
KTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASNCNGSLAHPSDLYAEGCEALVVKKLQEIMMHVI

--------------------------------------------------------------
>97647_97647_5_USP8-TSPAN3_USP8_chr15_50763992_ENST00000425032_TSPAN3_chr15_77348597_ENST00000267970_length(transcript)=4328nt_BP=811nt
AAATCGGGAAAAGGGGGTGAGCTGGGCTGGCTTCCGTCCTGGTAGCCAAGGCTAATTCTCCCTCGAGTTCTTGGGAGATGGGCATTTGGC
GAGAAGGCTGGCGTTAGTGAAGCGCGCCCGGCGTCACGGAAAGAAGCACTTGTAAGGAAATATAGCATCCATTGTGAAAGTGGAAAAGTA
AAGATAATTCATCATGCCTGCTGTGGCTTCAGTTCCTAAAGAACTCTACCTCAGTTCTTCACTAAAAGACCTTAATAAGAAGACAGAAGT
TAAACCAGAGAAAATAAGCACTAAGAGATATGAAGAAGCTGAAGTCCGGAAAAAACTTGAGGAAAAAGACAGGCAGGAGGAAGCACAGCG
GCTACAACAAAAAAGGCAGGAAACAGGAAGAGAGGATGGTGGCACATTGGCTAAAGGCTCTTTGGAGAATGTTTTGGATTCCAAAGACAA
AACCCAAAAGAGCAATGGTGAAAAGAATGAAAAATGTGAGACCAAAGAGAAAGGAGCAATCACAGCAAAGGAACTATACACAATGATGAC
GGATAAAAACATCAGCTTGATTATAATGGATGCTCGAAGAATGCAGGATTATCAGGATTCCTGTATTTTACATTCTCTCAGTGTTCCTGA
AGAAGCCATCAGTCCAGGAGTCACTGCTAGTTGGATTGAAGCACACCTGCCAGATGATTCTAAAGACACATGGAAGAAGAGGGGGAATGT
GGAGTATGTGGTACTTCTTGACTGGTTTAGTTCTGCCAAAGATTTACAGATTGGAACAACTCTCCGGAGTCTGAAAGATGCACTTTTCAA
GGGGGCAGCTGGCATTTTATGCTATGTGGGAGCCTATGTCTTCATCACTTATGATGACTATGACCACTTCTTTGAAGATGTGTACACGCT
CATCCCTGCTGTAGTGATCATAGCTGTAGGAGCCCTGCTTTTCATCATTGGGCTAATTGGCTGCTGTGCCACAATCCGGGAAAGTCGCTG
TGGACTTGCCACGTTTGTCATCATCCTGCTCTTGGTTTTTGTCACAGAAGTTGTTGTAGTGGTTTTGGGATATGTTTACAGAGCAAAGGT
GGAAAATGAGGTTGATCGCAGCATTCAGAAAGTGTATAAGACCTACAATGGAACCAACCCTGATGCTGCTAGCCGGGCTATTGATTATGT
ACAGAGACAGCTGCATTGTTGTGGAATTCACAACTACTCAGACTGGGAAAATACAGATTGGTTCAAAGAAACCAAAAACCAGAGTGTCCC
TCTTAGCTGCTGCAGAGAGACTGCCAGCAATTGTAATGGCAGCCTGGCCCACCCTTCCGACCTCTATGCTGAGGGGTGTGAGGCTCTAGT
AGTGAAGAAGCTACAAGAAATCATGATGCATGTGATCTGGGCCGCACTGGCATTTGCAGCTATTCAGCTGCTGGGCATGCTGTGTGCTTG
CATCGTGTTGTGCAGAAGGAGTAGAGATCCTGCTTACGAGCTCCTCATCACTGGCGGAACCTATGCATAGTTGACAACTCAAGCCTGAGC
TTTTTGGTCTTGTTCTGATTTGGAAGGTGAATTGAGCAGGTCTGCTGCTGTTGGCCTCTGGAGTTCATTTAGTTAAAGCACATGTACACT
GGTGTTGGACAGAGCAGCTTGGCTTTTCATGTGCCCACCTACTTACCTACTACCTGCGACTTTCTTTTTCCTTGTTCTAGCTGACTCTTC
ATGCCCCTAAGATTTTAAGTACGATGGTGAACGTTCTAATTTCAGAACCAATTGCGAGTCATGTAGTGTGGTAGAATTAAAGGAGGACAC
GAGCCTGCTTCTGTTACCTCCAAGTGGTAACAGGACTGATGCCGAAATGTCACCAGGTCCTTTCAGTCTTCACAGTGGAGAACTCTTGGC
CAAAGGTTTTTGCGGGGAGGAGGAGGAAACCAGCTTTCTGGTTAAGGTTAACACCAGATGGTGCCCCTCATTGGTGTCCTTTTAAAAAAT
ATTTACTGTAGTCCAATAAGATAGCAGCTGTACAAAATGACTAAAATAGATTGTAGGATCATATGGCGTATATCTTGGTTCATCTTCAAA
ATCAGAGACTGAGCTTTGAAACTAGTGGTTTTTAATCAAAGTTGGCTTTATAGGAGGAGTATAATGTATGCACTACTGTTTTAAAAGAAT
TAGTGTGAGTGTGTTTTTGTATGAATGAGCCCATTCATGGTAAGTCTTAAGCTTGTTGGAAATAATGTACCCATGTAGACTAGCAAAATA
GTATGTAGATGTGATCTCAGTTGTAAATAGAAAAATCTAATTCAATAAACTCTGTATCAGCCCCCAACATATTATTTTTCATTATTTGGG
GGATATTTCAGTTCCAGAGCAGCAGTATCATGTTTTCTTTGTTGGTGCTGTCTATAGTTCATCATGGTTTACGTGTGTTTTCGTTATAGC
TGTTGCCAGATTCTAAAGGGCTTGATATTCAAAAAACCACAGATGCTTTCAGTCCAGTATATCCTAGAAATATAGAGCTCTACTTTGTGC
AATGCACTGGGGATACAGTGGCGATACTGTCCTTGTCTTCAAGGAGTTCGGAGTCCTAGTATAGGAGACATACATAGGAGAAGATAATTT
TCACACTGCAGTGGTTGTAGTAATAGAATGGGAGTCCAAAGGGGAGTTCCGGAGAGGTCAGGGGTGACTTCCTGGAGGAGATGCCCAAGC
TTGGAGGCTGGATAGGCTTTGTTGAAAGATGGTACACAAGAGTGTGAAACAAAATTGTGTGTGCAGGGAGCTTAAAATACAAGGCTGGGG
AAAGAAGTTGGAGAAGCAGGAAAGCCCAGGCCCTCTAGTGTCTTACGGAACATCCTGTGGAGGTGAGAGCTGACTTGTAGGTGGAAGCAG
CTCTTTGGAGGTTTGATTTGGAAGGTGAACTGAGAAGAAGGTGGTGATGCAAGCCGGCCGTGCTGAAGCCAGGATGAATTGGTGTGACTG
GGCTTCAGTTAGGCTGGCATAGCAGTTGAGAGAGCTTAGCAGTGGGCAGCAGGGCACTGTTGGGGGCGGTGGTGAGCGGTGGATTCTGGC
TGTTTGGAGGCAGGACAGTGGTGGAATTCGATCATTGATTGGACGTGGGACAGAGAAGGGAGAAGAGAAGACTCATCTAGGATGAGTCCC
AGGTTTCTGGCTCAGTCAACTGGGGAAACAAAGTCACAGAGCTAGGGAGTAGTTAGAGAACACATCTGGGGGTGTGACTCATGGTCAGTT
TTGGGCTCGTCAGTTTTGAGATGCCCAAATATCATGCAGATCTGTCCCACCTGAAAATGGAGAAGACACGGGAAAGGAGAGGAGTAAAAA
CTAACTCCTTTTCACAAAGTGGAAGTTACCAGAATGTGATTTCAGAGGCCCCGGGGGATTTATCATGTGACTACTGACCCATCCCACCTC
TTGCCCCTGCCTGTTGCACAGTGGGCAAGAATGTTTGTGACCTTTCACTACCACCACCTCCCCCGAGCATGGTCCCCCCAGTTTTCAATA
TGAACCATCCTGTGGGTACCCTGTCACAGGCTGGCCCTGAGGTGAGCAATATTTGGACTGTGATGTTGGTTGTTCTCCACTCTTTCTACA
GGACAGAACAGGGCCTCTAGAGTGGGAAATGGCTTTGGGAAATATGCCAAGCAGTAGCCTTGTTCTTCAACTTGCCCAAGAGGATAATTC
TCCACACCCTTCCTGTACTCAGTCCTCAGTTTGCCTGGTGAGAGAGCAGCCTCCTCCCGTGTGCTCTGCCAGCTGGACCCAGACTGGCCA
TATTACCAGTGAGACCAAAAAGATGGAGGTGGGGAGGTAGCTCTGAGGTCTGGGAAACCATTCCAGCTCCTGCCAGTTTTAACTTGTGTT
TAATTCCTGGCACAGTTGTCCTGGAAATGCCTTTTTCTCTTGCCTGGGAACCACTAGAAGGGGATGTTGTCTGTGTTGGCCAGGGCCATG
CAAATTCAACATCTTGTTTCTGCCCTTCCCCCGTGTAGCTGAGGCTAGGTGTTGGCATTACCCAGTGCTTGTTCTTCAGAGAGCAAAAGC
ACTGCTCGTCATGTCTGAAATTTAGTGAGTGAGCTCACCCACTAGGCTGGTGTTTCCTGCCCGTGGCTGCACATTGGAAGCACCGGGGCA
CTTTGAGAACTACAGATGCCTGGGTCCCAGAGCATCTAAGGTGCTCTAGGGTGTGTCCAGGACACAGCCCTGGTTGAGGACCACTGCTAT
ATTGTATGGCCTCTTTTAAAAAAGTTAATTTTACTTGGAAATGATTTCAAAGCTACAGAAAAGTTGCAAGAATAAAAACTGTACAAATGA

>97647_97647_5_USP8-TSPAN3_USP8_chr15_50763992_ENST00000425032_TSPAN3_chr15_77348597_ENST00000267970_length(amino acids)=438AA_BP=206
MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKS
NGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVV
LLDWFSSAKDLQIGTTLRSLKDALFKGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLAT
FVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCC

--------------------------------------------------------------
>97647_97647_6_USP8-TSPAN3_USP8_chr15_50763992_ENST00000425032_TSPAN3_chr15_77348597_ENST00000346495_length(transcript)=2240nt_BP=811nt
AAATCGGGAAAAGGGGGTGAGCTGGGCTGGCTTCCGTCCTGGTAGCCAAGGCTAATTCTCCCTCGAGTTCTTGGGAGATGGGCATTTGGC
GAGAAGGCTGGCGTTAGTGAAGCGCGCCCGGCGTCACGGAAAGAAGCACTTGTAAGGAAATATAGCATCCATTGTGAAAGTGGAAAAGTA
AAGATAATTCATCATGCCTGCTGTGGCTTCAGTTCCTAAAGAACTCTACCTCAGTTCTTCACTAAAAGACCTTAATAAGAAGACAGAAGT
TAAACCAGAGAAAATAAGCACTAAGAGATATGAAGAAGCTGAAGTCCGGAAAAAACTTGAGGAAAAAGACAGGCAGGAGGAAGCACAGCG
GCTACAACAAAAAAGGCAGGAAACAGGAAGAGAGGATGGTGGCACATTGGCTAAAGGCTCTTTGGAGAATGTTTTGGATTCCAAAGACAA
AACCCAAAAGAGCAATGGTGAAAAGAATGAAAAATGTGAGACCAAAGAGAAAGGAGCAATCACAGCAAAGGAACTATACACAATGATGAC
GGATAAAAACATCAGCTTGATTATAATGGATGCTCGAAGAATGCAGGATTATCAGGATTCCTGTATTTTACATTCTCTCAGTGTTCCTGA
AGAAGCCATCAGTCCAGGAGTCACTGCTAGTTGGATTGAAGCACACCTGCCAGATGATTCTAAAGACACATGGAAGAAGAGGGGGAATGT
GGAGTATGTGGTACTTCTTGACTGGTTTAGTTCTGCCAAAGATTTACAGATTGGAACAACTCTCCGGAGTCTGAAAGATGCACTTTTCAA
GGGGGCAGCTGGCATTTTATGCTATGTGGGAGCCTATGTCTTCATCACTTATGATGACTATGACCACTTCTTTGAAGATGTGTACACGCT
CATCCCTGCTGTAGTGATCATAGCTGTAGGAGCCCTGCTTTTCATCATTGGGCTAATTGGCTGCTGTGCCACAATCCGGGAAAGTCGCTG
TGGACTTGCCACGGTGGAAAATGAGGTTGATCGCAGCATTCAGAAAGTGTATAAGACCTACAATGGAACCAACCCTGATGCTGCTAGCCG
GGCTATTGATTATGTACAGAGACAGCTGCATTGTTGTGGAATTCACAACTACTCAGACTGGGAAAATACAGATTGGTTCAAAGAAACCAA
AAACCAGAGTGTCCCTCTTAGCTGCTGCAGAGAGACTGCCAGCAATTGTAATGGCAGCCTGGCCCACCCTTCCGACCTCTATGCTGAGGG
GTGTGAGGCTCTAGTAGTGAAGAAGCTACAAGAAATCATGATGCATGTGATCTGGGCCGCACTGGCATTTGCAGCTATTCAGCTGCTGGG
CATGCTGTGTGCTTGCATCGTGTTGTGCAGAAGGAGTAGAGATCCTGCTTACGAGCTCCTCATCACTGGCGGAACCTATGCATAGTTGAC
AACTCAAGCCTGAGCTTTTTGGTCTTGTTCTGATTTGGAAGGTGAATTGAGCAGGTCTGCTGCTGTTGGCCTCTGGAGTTCATTTAGTTA
AAGCACATGTACACTGGTGTTGGACAGAGCAGCTTGGCTTTTCATGTGCCCACCTACTTACCTACTACCTGCGACTTTCTTTTTCCTTGT
TCTAGCTGACTCTTCATGCCCCTAAGATTTTAAGTACGATGGTGAACGTTCTAATTTCAGAACCAATTGCGAGTCATGTAGTGTGGTAGA
ATTAAAGGAGGACACGAGCCTGCTTCTGTTACCTCCAAGTGGTAACAGGACTGATGCCGAAATGTCACCAGGTCCTTTCAGTCTTCACAG
TGGAGAACTCTTGGCCAAAGGTTTTTGCGGGGAGGAGGAGGAAACCAGCTTTCTGGTTAAGGTTAACACCAGATGGTGCCCCTCATTGGT
GTCCTTTTAAAAAATATTTACTGTAGTCCAATAAGATAGCAGCTGTACAAAATGACTAAAATAGATTGTAGGATCATATGGCGTATATCT
TGGTTCATCTTCAAAATCAGAGACTGAGCTTTGAAACTAGTGGTTTTTAATCAAAGTTGGCTTTATAGGAGGAGTATAATGTATGCACTA
CTGTTTTAAAAGAATTAGTGTGAGTGTGTTTTTGTATGAATGAGCCCATTCATGGTAAGTCTTAAGCTTGTTGGAAATAATGTACCCATG

>97647_97647_6_USP8-TSPAN3_USP8_chr15_50763992_ENST00000425032_TSPAN3_chr15_77348597_ENST00000346495_length(amino acids)=413AA_BP=206
MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKS
NGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVV
LLDWFSSAKDLQIGTTLRSLKDALFKGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLAT
VENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASNCNGSLAHPSDLYAEGCEAL

--------------------------------------------------------------
>97647_97647_7_USP8-TSPAN3_USP8_chr15_50763992_ENST00000433963_TSPAN3_chr15_77348597_ENST00000267970_length(transcript)=4866nt_BP=1349nt
AATGCAAATCGGGAAAAGGGGGTGAGCTGGGCTGGCTTCCGTCCTGGTAGCCAAGGCTAATTCTCCCTCGAGTTCTTGGGAGATGGGCAT
TTGGCGAGAAGGCTGGCGTTAGTGAAGCGCGCCCGGCGTCACGGTGAGTGCGGGTCTTGGGCCCTAGCACCTGTTCTCTGGGAAGTCGTC
CGCTGTGAACGATGAACGCCTTTCCTTCCACCAGCTGCTGGTTACCCCGGAGACAAGCTCTGTCCGCGGAGAGGAGTGGGACAACTCCTA
AAGGCAACAACAATACTCAACATAAATATCTGTTCTTGAACTCCTGGGCTCAAGCAGTCCTCCCACCTCAGTCTCCCAGAGTGTTGGGAT
TACAGCTGTGAGGCACCACGCCCAGTCAGTGCACTGCTTTTTGCATGGAGAAAGTCTTGCTGCTACTTTAAAAAGGAAAGAAGCACTTGT
AAGGAAATATAGCATCCATTGTGAAAGTGGAAAAGTAAAGATAATTCATCATGCCTGCTGTGGCTTCAGTTCCTAAAGAACTCTACCTCA
GTTCTTCACTAAAAGACCTTAATAAGAAGACAGAAGTTAAACCAGAGAAAATAAGCACTAAGAGTTATGTGCACAGTGCCCTGAAGATCT
TTAAGACAGCAGAAGAATGCAGATTAGATCGTGATGAGGAAAGGGCCTATGTACTATATATGAAATACGTGACTGTTTATAATCTTATCA
AAAAAAGACCTGATTTCAAGCAACAGCAGGATTATTTCCATTCAATACTTGGACCTGGAAACATCAAAAAAGCTGTCGAAGAAGCTGAAA
GACTCTCTGAAAGCCTTAAATTAAGATATGAAGAAGCTGAAGTCCGGAAAAAACTTGAGGAAAAAGACAGGCAGGAGGAAGCACAGCGGC
TACAACAAAAAAGGCAGGAAACAGGAAGAGAGGATGGTGGCACATTGGCTAAAGGCTCTTTGGAGAATGTTTTGGATTCCAAAGACAAAA
CCCAAAAGAGCAATGGTGAAAAGAATGAAAAATGTGAGACCAAAGAGAAAGGAGCAATCACAGCAAAGGAACTATACACAATGATGACGG
ATAAAAACATCAGCTTGATTATAATGGATGCTCGAAGAATGCAGGATTATCAGGATTCCTGTATTTTACATTCTCTCAGTGTTCCTGAAG
AAGCCATCAGTCCAGGAGTCACTGCTAGTTGGATTGAAGCACACCTGCCAGATGATTCTAAAGACACATGGAAGAAGAGGGGGAATGTGG
AGTATGTGGTACTTCTTGACTGGTTTAGTTCTGCCAAAGATTTACAGATTGGAACAACTCTCCGGAGTCTGAAAGATGCACTTTTCAAGG
GGGCAGCTGGCATTTTATGCTATGTGGGAGCCTATGTCTTCATCACTTATGATGACTATGACCACTTCTTTGAAGATGTGTACACGCTCA
TCCCTGCTGTAGTGATCATAGCTGTAGGAGCCCTGCTTTTCATCATTGGGCTAATTGGCTGCTGTGCCACAATCCGGGAAAGTCGCTGTG
GACTTGCCACGTTTGTCATCATCCTGCTCTTGGTTTTTGTCACAGAAGTTGTTGTAGTGGTTTTGGGATATGTTTACAGAGCAAAGGTGG
AAAATGAGGTTGATCGCAGCATTCAGAAAGTGTATAAGACCTACAATGGAACCAACCCTGATGCTGCTAGCCGGGCTATTGATTATGTAC
AGAGACAGCTGCATTGTTGTGGAATTCACAACTACTCAGACTGGGAAAATACAGATTGGTTCAAAGAAACCAAAAACCAGAGTGTCCCTC
TTAGCTGCTGCAGAGAGACTGCCAGCAATTGTAATGGCAGCCTGGCCCACCCTTCCGACCTCTATGCTGAGGGGTGTGAGGCTCTAGTAG
TGAAGAAGCTACAAGAAATCATGATGCATGTGATCTGGGCCGCACTGGCATTTGCAGCTATTCAGCTGCTGGGCATGCTGTGTGCTTGCA
TCGTGTTGTGCAGAAGGAGTAGAGATCCTGCTTACGAGCTCCTCATCACTGGCGGAACCTATGCATAGTTGACAACTCAAGCCTGAGCTT
TTTGGTCTTGTTCTGATTTGGAAGGTGAATTGAGCAGGTCTGCTGCTGTTGGCCTCTGGAGTTCATTTAGTTAAAGCACATGTACACTGG
TGTTGGACAGAGCAGCTTGGCTTTTCATGTGCCCACCTACTTACCTACTACCTGCGACTTTCTTTTTCCTTGTTCTAGCTGACTCTTCAT
GCCCCTAAGATTTTAAGTACGATGGTGAACGTTCTAATTTCAGAACCAATTGCGAGTCATGTAGTGTGGTAGAATTAAAGGAGGACACGA
GCCTGCTTCTGTTACCTCCAAGTGGTAACAGGACTGATGCCGAAATGTCACCAGGTCCTTTCAGTCTTCACAGTGGAGAACTCTTGGCCA
AAGGTTTTTGCGGGGAGGAGGAGGAAACCAGCTTTCTGGTTAAGGTTAACACCAGATGGTGCCCCTCATTGGTGTCCTTTTAAAAAATAT
TTACTGTAGTCCAATAAGATAGCAGCTGTACAAAATGACTAAAATAGATTGTAGGATCATATGGCGTATATCTTGGTTCATCTTCAAAAT
CAGAGACTGAGCTTTGAAACTAGTGGTTTTTAATCAAAGTTGGCTTTATAGGAGGAGTATAATGTATGCACTACTGTTTTAAAAGAATTA
GTGTGAGTGTGTTTTTGTATGAATGAGCCCATTCATGGTAAGTCTTAAGCTTGTTGGAAATAATGTACCCATGTAGACTAGCAAAATAGT
ATGTAGATGTGATCTCAGTTGTAAATAGAAAAATCTAATTCAATAAACTCTGTATCAGCCCCCAACATATTATTTTTCATTATTTGGGGG
ATATTTCAGTTCCAGAGCAGCAGTATCATGTTTTCTTTGTTGGTGCTGTCTATAGTTCATCATGGTTTACGTGTGTTTTCGTTATAGCTG
TTGCCAGATTCTAAAGGGCTTGATATTCAAAAAACCACAGATGCTTTCAGTCCAGTATATCCTAGAAATATAGAGCTCTACTTTGTGCAA
TGCACTGGGGATACAGTGGCGATACTGTCCTTGTCTTCAAGGAGTTCGGAGTCCTAGTATAGGAGACATACATAGGAGAAGATAATTTTC
ACACTGCAGTGGTTGTAGTAATAGAATGGGAGTCCAAAGGGGAGTTCCGGAGAGGTCAGGGGTGACTTCCTGGAGGAGATGCCCAAGCTT
GGAGGCTGGATAGGCTTTGTTGAAAGATGGTACACAAGAGTGTGAAACAAAATTGTGTGTGCAGGGAGCTTAAAATACAAGGCTGGGGAA
AGAAGTTGGAGAAGCAGGAAAGCCCAGGCCCTCTAGTGTCTTACGGAACATCCTGTGGAGGTGAGAGCTGACTTGTAGGTGGAAGCAGCT
CTTTGGAGGTTTGATTTGGAAGGTGAACTGAGAAGAAGGTGGTGATGCAAGCCGGCCGTGCTGAAGCCAGGATGAATTGGTGTGACTGGG
CTTCAGTTAGGCTGGCATAGCAGTTGAGAGAGCTTAGCAGTGGGCAGCAGGGCACTGTTGGGGGCGGTGGTGAGCGGTGGATTCTGGCTG
TTTGGAGGCAGGACAGTGGTGGAATTCGATCATTGATTGGACGTGGGACAGAGAAGGGAGAAGAGAAGACTCATCTAGGATGAGTCCCAG
GTTTCTGGCTCAGTCAACTGGGGAAACAAAGTCACAGAGCTAGGGAGTAGTTAGAGAACACATCTGGGGGTGTGACTCATGGTCAGTTTT
GGGCTCGTCAGTTTTGAGATGCCCAAATATCATGCAGATCTGTCCCACCTGAAAATGGAGAAGACACGGGAAAGGAGAGGAGTAAAAACT
AACTCCTTTTCACAAAGTGGAAGTTACCAGAATGTGATTTCAGAGGCCCCGGGGGATTTATCATGTGACTACTGACCCATCCCACCTCTT
GCCCCTGCCTGTTGCACAGTGGGCAAGAATGTTTGTGACCTTTCACTACCACCACCTCCCCCGAGCATGGTCCCCCCAGTTTTCAATATG
AACCATCCTGTGGGTACCCTGTCACAGGCTGGCCCTGAGGTGAGCAATATTTGGACTGTGATGTTGGTTGTTCTCCACTCTTTCTACAGG
ACAGAACAGGGCCTCTAGAGTGGGAAATGGCTTTGGGAAATATGCCAAGCAGTAGCCTTGTTCTTCAACTTGCCCAAGAGGATAATTCTC
CACACCCTTCCTGTACTCAGTCCTCAGTTTGCCTGGTGAGAGAGCAGCCTCCTCCCGTGTGCTCTGCCAGCTGGACCCAGACTGGCCATA
TTACCAGTGAGACCAAAAAGATGGAGGTGGGGAGGTAGCTCTGAGGTCTGGGAAACCATTCCAGCTCCTGCCAGTTTTAACTTGTGTTTA
ATTCCTGGCACAGTTGTCCTGGAAATGCCTTTTTCTCTTGCCTGGGAACCACTAGAAGGGGATGTTGTCTGTGTTGGCCAGGGCCATGCA
AATTCAACATCTTGTTTCTGCCCTTCCCCCGTGTAGCTGAGGCTAGGTGTTGGCATTACCCAGTGCTTGTTCTTCAGAGAGCAAAAGCAC
TGCTCGTCATGTCTGAAATTTAGTGAGTGAGCTCACCCACTAGGCTGGTGTTTCCTGCCCGTGGCTGCACATTGGAAGCACCGGGGCACT
TTGAGAACTACAGATGCCTGGGTCCCAGAGCATCTAAGGTGCTCTAGGGTGTGTCCAGGACACAGCCCTGGTTGAGGACCACTGCTATAT
TGTATGGCCTCTTTTAAAAAAGTTAATTTTACTTGGAAATGATTTCAAAGCTACAGAAAAGTTGCAAGAATAAAAACTGTACAAATGAGG

>97647_97647_7_USP8-TSPAN3_USP8_chr15_50763992_ENST00000433963_TSPAN3_chr15_77348597_ENST00000267970_length(amino acids)=515AA_BP=283
MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSIL
GPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK
GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQI
GTTLRSLKDALFKGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEV
VVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASNCNGSLAH

--------------------------------------------------------------
>97647_97647_8_USP8-TSPAN3_USP8_chr15_50763992_ENST00000433963_TSPAN3_chr15_77348597_ENST00000346495_length(transcript)=2778nt_BP=1349nt
AATGCAAATCGGGAAAAGGGGGTGAGCTGGGCTGGCTTCCGTCCTGGTAGCCAAGGCTAATTCTCCCTCGAGTTCTTGGGAGATGGGCAT
TTGGCGAGAAGGCTGGCGTTAGTGAAGCGCGCCCGGCGTCACGGTGAGTGCGGGTCTTGGGCCCTAGCACCTGTTCTCTGGGAAGTCGTC
CGCTGTGAACGATGAACGCCTTTCCTTCCACCAGCTGCTGGTTACCCCGGAGACAAGCTCTGTCCGCGGAGAGGAGTGGGACAACTCCTA
AAGGCAACAACAATACTCAACATAAATATCTGTTCTTGAACTCCTGGGCTCAAGCAGTCCTCCCACCTCAGTCTCCCAGAGTGTTGGGAT
TACAGCTGTGAGGCACCACGCCCAGTCAGTGCACTGCTTTTTGCATGGAGAAAGTCTTGCTGCTACTTTAAAAAGGAAAGAAGCACTTGT
AAGGAAATATAGCATCCATTGTGAAAGTGGAAAAGTAAAGATAATTCATCATGCCTGCTGTGGCTTCAGTTCCTAAAGAACTCTACCTCA
GTTCTTCACTAAAAGACCTTAATAAGAAGACAGAAGTTAAACCAGAGAAAATAAGCACTAAGAGTTATGTGCACAGTGCCCTGAAGATCT
TTAAGACAGCAGAAGAATGCAGATTAGATCGTGATGAGGAAAGGGCCTATGTACTATATATGAAATACGTGACTGTTTATAATCTTATCA
AAAAAAGACCTGATTTCAAGCAACAGCAGGATTATTTCCATTCAATACTTGGACCTGGAAACATCAAAAAAGCTGTCGAAGAAGCTGAAA
GACTCTCTGAAAGCCTTAAATTAAGATATGAAGAAGCTGAAGTCCGGAAAAAACTTGAGGAAAAAGACAGGCAGGAGGAAGCACAGCGGC
TACAACAAAAAAGGCAGGAAACAGGAAGAGAGGATGGTGGCACATTGGCTAAAGGCTCTTTGGAGAATGTTTTGGATTCCAAAGACAAAA
CCCAAAAGAGCAATGGTGAAAAGAATGAAAAATGTGAGACCAAAGAGAAAGGAGCAATCACAGCAAAGGAACTATACACAATGATGACGG
ATAAAAACATCAGCTTGATTATAATGGATGCTCGAAGAATGCAGGATTATCAGGATTCCTGTATTTTACATTCTCTCAGTGTTCCTGAAG
AAGCCATCAGTCCAGGAGTCACTGCTAGTTGGATTGAAGCACACCTGCCAGATGATTCTAAAGACACATGGAAGAAGAGGGGGAATGTGG
AGTATGTGGTACTTCTTGACTGGTTTAGTTCTGCCAAAGATTTACAGATTGGAACAACTCTCCGGAGTCTGAAAGATGCACTTTTCAAGG
GGGCAGCTGGCATTTTATGCTATGTGGGAGCCTATGTCTTCATCACTTATGATGACTATGACCACTTCTTTGAAGATGTGTACACGCTCA
TCCCTGCTGTAGTGATCATAGCTGTAGGAGCCCTGCTTTTCATCATTGGGCTAATTGGCTGCTGTGCCACAATCCGGGAAAGTCGCTGTG
GACTTGCCACGGTGGAAAATGAGGTTGATCGCAGCATTCAGAAAGTGTATAAGACCTACAATGGAACCAACCCTGATGCTGCTAGCCGGG
CTATTGATTATGTACAGAGACAGCTGCATTGTTGTGGAATTCACAACTACTCAGACTGGGAAAATACAGATTGGTTCAAAGAAACCAAAA
ACCAGAGTGTCCCTCTTAGCTGCTGCAGAGAGACTGCCAGCAATTGTAATGGCAGCCTGGCCCACCCTTCCGACCTCTATGCTGAGGGGT
GTGAGGCTCTAGTAGTGAAGAAGCTACAAGAAATCATGATGCATGTGATCTGGGCCGCACTGGCATTTGCAGCTATTCAGCTGCTGGGCA
TGCTGTGTGCTTGCATCGTGTTGTGCAGAAGGAGTAGAGATCCTGCTTACGAGCTCCTCATCACTGGCGGAACCTATGCATAGTTGACAA
CTCAAGCCTGAGCTTTTTGGTCTTGTTCTGATTTGGAAGGTGAATTGAGCAGGTCTGCTGCTGTTGGCCTCTGGAGTTCATTTAGTTAAA
GCACATGTACACTGGTGTTGGACAGAGCAGCTTGGCTTTTCATGTGCCCACCTACTTACCTACTACCTGCGACTTTCTTTTTCCTTGTTC
TAGCTGACTCTTCATGCCCCTAAGATTTTAAGTACGATGGTGAACGTTCTAATTTCAGAACCAATTGCGAGTCATGTAGTGTGGTAGAAT
TAAAGGAGGACACGAGCCTGCTTCTGTTACCTCCAAGTGGTAACAGGACTGATGCCGAAATGTCACCAGGTCCTTTCAGTCTTCACAGTG
GAGAACTCTTGGCCAAAGGTTTTTGCGGGGAGGAGGAGGAAACCAGCTTTCTGGTTAAGGTTAACACCAGATGGTGCCCCTCATTGGTGT
CCTTTTAAAAAATATTTACTGTAGTCCAATAAGATAGCAGCTGTACAAAATGACTAAAATAGATTGTAGGATCATATGGCGTATATCTTG
GTTCATCTTCAAAATCAGAGACTGAGCTTTGAAACTAGTGGTTTTTAATCAAAGTTGGCTTTATAGGAGGAGTATAATGTATGCACTACT
GTTTTAAAAGAATTAGTGTGAGTGTGTTTTTGTATGAATGAGCCCATTCATGGTAAGTCTTAAGCTTGTTGGAAATAATGTACCCATGTA

>97647_97647_8_USP8-TSPAN3_USP8_chr15_50763992_ENST00000433963_TSPAN3_chr15_77348597_ENST00000346495_length(amino acids)=490AA_BP=283
MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSIL
GPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK
GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQI
GTTLRSLKDALFKGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGLATVENEVDRSIQKVY
KTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASNCNGSLAHPSDLYAEGCEALVVKKLQEIMMHVI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USP8-TSPAN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP8-TSPAN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP8-TSPAN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource