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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:UVRAG-MS4A8 (FusionGDB2 ID:97799)

Fusion Gene Summary for UVRAG-MS4A8

Fusion gene summary

Fusion gene information	Fusion gene name: UVRAG-MS4A8
	Fusion gene ID: 97799
		Hgene	Tgene
	Gene symbol	UVRAG	MS4A8
	Gene ID	7405	83661
	Gene name	UV radiation resistance associated	membrane spanning 4-domains A8
	Synonyms	DHTX\|VPS38\|p63	4SPAN4\|CD20L5\|MS4A4\|MS4A8B
	Cytomap	11q13.5	11q12.2
	Type of gene	protein-coding	protein-coding
	Description	UV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxy	membrane-spanning 4-domains subfamily A member 8four-span transmembrane protein 4membrane-spanning 4-domains, subfamily A, member 8B
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000531818, ENST00000532130, ENST00000533454, ENST00000539288, ENST00000356136, ENST00000528420, ENST00000525872, ENST00000538870,	ENST00000300226,
Fusion gene scores	* DoF score	41 X 18 X 15=11070	2 X 2 X 2=8
	# samples	49	2
	** MAII score	log2(49/11070*10)=-4.49772966266634 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: UVRAG [Title/Abstract] AND MS4A8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	UVRAG(75718665)-MS4A8(60470851), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UVRAG	GO:0071900	regulation of protein serine/threonine kinase activity	22542840
Hgene	UVRAG	GO:0097352	autophagosome maturation	28306502
Hgene	UVRAG	GO:0097680	double-strand break repair via classical nonhomologous end joining	22542840

Fusion gene breakpoints across UVRAG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MS4A8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-3B-A9HQ-01A	UVRAG	chr11	75718665	+	MS4A8	chr11	60470851	+
ChimerDB4	SARC	TCGA-3R-A8YX-01A	UVRAG	chr11	75718665	+	MS4A8	chr11	60470851	+

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Fusion Gene ORF analysis for UVRAG-MS4A8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000531818	ENST00000300226	UVRAG	chr11	75718665	+	MS4A8	chr11	60470851	+
5UTR-3CDS	ENST00000532130	ENST00000300226	UVRAG	chr11	75718665	+	MS4A8	chr11	60470851	+
5UTR-3CDS	ENST00000533454	ENST00000300226	UVRAG	chr11	75718665	+	MS4A8	chr11	60470851	+
5UTR-3CDS	ENST00000539288	ENST00000300226	UVRAG	chr11	75718665	+	MS4A8	chr11	60470851	+
In-frame	ENST00000356136	ENST00000300226	UVRAG	chr11	75718665	+	MS4A8	chr11	60470851	+
In-frame	ENST00000528420	ENST00000300226	UVRAG	chr11	75718665	+	MS4A8	chr11	60470851	+
intron-3CDS	ENST00000525872	ENST00000300226	UVRAG	chr11	75718665	+	MS4A8	chr11	60470851	+
intron-3CDS	ENST00000538870	ENST00000300226	UVRAG	chr11	75718665	+	MS4A8	chr11	60470851	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000356136

UVRAG

chr11

75718665

ENST00000300226

MS4A8

chr11

60470851

2171

1240

163

1773

536

ENST00000528420

UVRAG

chr11

75718665

ENST00000300226

MS4A8

chr11

60470851

1912

981

1514

472

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000356136	ENST00000300226	UVRAG	chr11	75718665	+	MS4A8	chr11	60470851	+	0.003788672	0.9962113
ENST00000528420	ENST00000300226	UVRAG	chr11	75718665	+	MS4A8	chr11	60470851	+	0.00382499	0.99617493

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Fusion Genomic Features for UVRAG-MS4A8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
UVRAG	chr11	75718665	+	MS4A8	chr11	60470850	+	9.13E-08	0.9999999
UVRAG	chr11	75718665	+	MS4A8	chr11	60470850	+	9.13E-08	0.9999999
UVRAG	chr11	75718665	+	MS4A8	chr11	60470850	+	9.13E-08	0.9999999
UVRAG	chr11	75718665	+	MS4A8	chr11	60470850	+	9.13E-08	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UVRAG-MS4A8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:75718665/chr11:60470851)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UVRAG

chr11:75718665

chr11:60470851

ENST00000356136

224_305

333

700.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

UVRAG

chr11:75718665

chr11:60470851

ENST00000356136

23_149

333

700.0

Domain

Tgene

MS4A8

chr11:75718665

chr11:60470851

ENST00000300226

120_136

251.0

Topological domain

Cytoplasmic

Tgene

MS4A8

chr11:75718665

chr11:60470851

ENST00000300226

158_180

251.0

Topological domain

Extracellular

Tgene

MS4A8

chr11:75718665

chr11:60470851

ENST00000300226

202_250

251.0

Topological domain

Cytoplasmic

Tgene

MS4A8

chr11:75718665

chr11:60470851

ENST00000300226

96_98

251.0

Topological domain

Extracellular

Tgene

MS4A8

chr11:75718665

chr11:60470851

ENST00000300226

137_157

251.0

Transmembrane

Helical

Tgene

MS4A8

chr11:75718665

chr11:60470851

ENST00000300226

181_201

251.0

Transmembrane

Helical

Tgene

MS4A8

chr11:75718665

chr11:60470851

ENST00000300226

75_95

251.0

Transmembrane

Helical

Tgene

MS4A8

chr11:75718665

chr11:60470851

ENST00000300226

99_119

251.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MS4A8

chr11:75718665

chr11:60470851

ENST00000300226

1_74

251.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for UVRAG-MS4A8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>97799_97799_1_UVRAG-MS4A8_UVRAG_chr11_75718665_ENST00000356136_MS4A8_chr11_60470851_ENST00000300226_length(transcript)=2171nt_BP=1240nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGCG
GCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTTACACTTCACTT
GTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGTCTCGATTTTGG
AATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAGCTGTTGATTGA
ATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGG
ATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTC
TTACGATGTCTTCTCTTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAAT
TGAAGAAAAACTAAGACTCACATCTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGA
ACTGGAACGGCAGAAGAAAGCTTTGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGAAGTGCATTTTC
AGCTGAGCACCTCAAACTTCAACTCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGAC
TAATGCTCAGTTGACAATTCGTTGCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGGCCATCCAGATCATCATTGG
CCTGGCTCACATCGGCCTCGGCTCCATCATGGCGACGGTTCTCGTAGGGGAATACCTGTCTATTTCATTCTACGGAGGCTTTCCCTTCTG
GGGAGGCTTGTGGTTTATCATTTCAGGATCTCTCTCCGTGGCAGCAGAAAATCAGCCATATTCTTATTGCCTGCTGTCTGGCAGTTTGGG
CTTGAACATCGTCAGTGCAATCTGCTCTGCAGTTGGAGTCATACTCTTCATCACAGATCTAAGTATTCCCCACCCATATGCCTACCCCGA
CTATTATCCTTACGCCTGGGGTGTGAACCCTGGAATGGCGATTTCTGGCGTGCTGCTGGTCTTCTGCCTCCTGGAGTTTGGCATCGCATG
CGCATCTTCCCACTTTGGCTGCCAGTTGGTCTGCTGTCAATCAAGCAATGTGAGTGTCATCTATCCAAACATCTATGCAGCAAACCCAGT
GATCACCCCAGAACCGGTGACCTCACCACCAAGTTATTCCAGTGAGATCCAAGCAAATAAGTAAGGCTACAGATTCTGGAAGCATCTTTC
ACTGGGACCAAAAGAAGTCCTCCTCCCTTTCTGGGCTTCCATAACCCAGGTCGTTCCTGTTCTGACAGCTGAGGAAACGTCTCTCCCACT
GTTTGTACTCTCACCTTCATTCTTCAATTCAGTCTAGGAAACCATGCTGTTTCTCTATCAAGAAGAAGACAGAGATTTTAAACAGATGTT
AACCAAGAGGGACTCCCTAGGGCACATGCATCAGCACATATGTGGGCATCCAGCCTCTGGGGCCTTGGCACACACACATTCGTGTGCTCT
GCTGCATGTGAGCTTGTGGGTTAGAGGAACAAATATCTAGACATTCAATCTTCACTCTTTCAATTGTGCATTCATTTAATAAATAGATAC

>97799_97799_1_UVRAG-MS4A8_UVRAG_chr11_75718665_ENST00000356136_MS4A8_chr11_60470851_ENST00000300226_length(amino acids)=536AA_BP=390
MVGGGKGAAADAGRVPAPPLGGPWIEMSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDT
YFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEII
FGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECLQLKI
LVLQNELERQKKALGREVALLHKQQIALQDKGSAFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLA
IQIIIGLAHIGLGSIMATVLVGEYLSISFYGGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSIPH

--------------------------------------------------------------
>97799_97799_2_UVRAG-MS4A8_UVRAG_chr11_75718665_ENST00000528420_MS4A8_chr11_60470851_ENST00000300226_length(transcript)=1912nt_BP=981nt
AGTGCTCAGCTCCCTTGCCATGCGATACCCTGCAAGTCCTCACCAGCAAAAAGGCTCTCACCAGAGGCTGCCCCTCGGCCTGTGTTATCA
GATTTTTTGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTT
ACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGT
CTCGATTTTGGAATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAG
CTGTTGATTGAATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGG
CTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGT
GTTCGCAATTCTTACGATGTCTTCTCTTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATT
GGAAAGGAAATTGAAGAAAAACTAAGACTCACATCTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTG
CTTCAGAATGAACTGGAACGGCAGAAGAAAGCTTTGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGA
AGTGCATTTTCAGCTGAGCACCTCAAACTTCAACTCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTC
TTCTTGAAGACTAATGCTCAGTTGACAATTCGTTGCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGGCCATCCAG
ATCATCATTGGCCTGGCTCACATCGGCCTCGGCTCCATCATGGCGACGGTTCTCGTAGGGGAATACCTGTCTATTTCATTCTACGGAGGC
TTTCCCTTCTGGGGAGGCTTGTGGTTTATCATTTCAGGATCTCTCTCCGTGGCAGCAGAAAATCAGCCATATTCTTATTGCCTGCTGTCT
GGCAGTTTGGGCTTGAACATCGTCAGTGCAATCTGCTCTGCAGTTGGAGTCATACTCTTCATCACAGATCTAAGTATTCCCCACCCATAT
GCCTACCCCGACTATTATCCTTACGCCTGGGGTGTGAACCCTGGAATGGCGATTTCTGGCGTGCTGCTGGTCTTCTGCCTCCTGGAGTTT
GGCATCGCATGCGCATCTTCCCACTTTGGCTGCCAGTTGGTCTGCTGTCAATCAAGCAATGTGAGTGTCATCTATCCAAACATCTATGCA
GCAAACCCAGTGATCACCCCAGAACCGGTGACCTCACCACCAAGTTATTCCAGTGAGATCCAAGCAAATAAGTAAGGCTACAGATTCTGG
AAGCATCTTTCACTGGGACCAAAAGAAGTCCTCCTCCCTTTCTGGGCTTCCATAACCCAGGTCGTTCCTGTTCTGACAGCTGAGGAAACG
TCTCTCCCACTGTTTGTACTCTCACCTTCATTCTTCAATTCAGTCTAGGAAACCATGCTGTTTCTCTATCAAGAAGAAGACAGAGATTTT
AAACAGATGTTAACCAAGAGGGACTCCCTAGGGCACATGCATCAGCACATATGTGGGCATCCAGCCTCTGGGGCCTTGGCACACACACAT
TCGTGTGCTCTGCTGCATGTGAGCTTGTGGGTTAGAGGAACAAATATCTAGACATTCAATCTTCACTCTTTCAATTGTGCATTCATTTAA

>97799_97799_2_UVRAG-MS4A8_UVRAG_chr11_75718665_ENST00000528420_MS4A8_chr11_60470851_ENST00000300226_length(amino acids)=472AA_BP=326
MRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLL
IEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGK
EIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGREVALLHKQQIALQDKGSAFSAEHLKLQLQKESLNELRKECTAKRELFL
KTNAQLTIRCRQLLSELSYIYPIDLAIQIIIGLAHIGLGSIMATVLVGEYLSISFYGGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGS
LGLNIVSAICSAVGVILFITDLSIPHPYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAAN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for UVRAG-MS4A8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for UVRAG-MS4A8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for UVRAG-MS4A8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source