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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UXS1-FHL2 (FusionGDB2 ID:97829)

Fusion Gene Summary for UXS1-FHL2

check button Fusion gene summary
Fusion gene informationFusion gene name: UXS1-FHL2
Fusion gene ID: 97829
HgeneTgene
Gene symbol

UXS1

FHL2

Gene ID

80146

2274

Gene nameUDP-glucuronate decarboxylase 1four and a half LIM domains 2
SynonymsSDR6E1|UGDAAG11|DRAL|FHL-2|SLIM-3|SLIM3
Cytomap

2q12.2

2q12.2

Type of geneprotein-codingprotein-coding
DescriptionUDP-glucuronic acid decarboxylase 1UXS-1short chain dehydrogenase/reductase family 6E, member 12four and a half LIM domains protein 2LIM domain protein DRALaging-associated gene 11down-regulated in rhabdomyosarcoma LIM proteinskeletal muscle LIM-protein 3
Modification date2020031320200327
UniProtAcc.

Q14192

Ensembl transtripts involved in fusion geneENST00000283148, ENST00000409032, 
ENST00000409501, ENST00000428048, 
ENST00000540130, ENST00000479621, 
ENST00000322142, ENST00000336660, 
ENST00000344213, ENST00000358129, 
ENST00000393352, ENST00000393353, 
ENST00000408995, ENST00000409177, 
ENST00000409807, ENST00000607522, 
Fusion gene scores* DoF score6 X 7 X 4=1687 X 3 X 5=105
# samples 79
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/105*10)=-0.222392421336448
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UXS1 [Title/Abstract] AND FHL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUXS1(106739425)-FHL2(106002997), # samples:1
UXS1(106810603)-FHL2(106002997), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFHL2

GO:0000122

negative regulation of transcription by RNA polymerase II

15692560

TgeneFHL2

GO:0043066

negative regulation of apoptotic process

15692560


check buttonFusion gene breakpoints across UXS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FHL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-6565UXS1chr2

106810603

-FHL2chr2

106002997

-
ChimerDB4STADTCGA-CG-5726UXS1chr2

106739425

-FHL2chr2

106002997

-


Top

Fusion Gene ORF analysis for UXS1-FHL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000283148ENST00000322142UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000322142UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000336660UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000336660UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000344213UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000344213UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000358129UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000358129UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000393352UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000393352UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000393353UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000393353UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000408995UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000408995UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000409177UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000409177UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000409807UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000409807UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000607522UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000283148ENST00000607522UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409032ENST00000322142UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409032ENST00000336660UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409032ENST00000344213UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409032ENST00000358129UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409032ENST00000393352UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409032ENST00000393353UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409032ENST00000408995UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409032ENST00000409177UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409032ENST00000409807UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409032ENST00000607522UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000322142UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000322142UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000336660UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000336660UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000344213UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000344213UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000358129UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000358129UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000393352UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000393352UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000393353UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000393353UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000408995UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000408995UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000409177UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000409177UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000409807UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000409807UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000607522UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000409501ENST00000607522UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000322142UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000322142UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000336660UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000336660UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000344213UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000344213UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000358129UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000358129UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000393352UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000393352UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000393353UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000393353UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000408995UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000408995UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000409177UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000409177UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000409807UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000409807UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000607522UXS1chr2

106810603

-FHL2chr2

106002997

-
5CDS-5UTRENST00000428048ENST00000607522UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000540130ENST00000322142UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000540130ENST00000336660UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000540130ENST00000344213UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000540130ENST00000358129UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000540130ENST00000393352UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000540130ENST00000393353UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000540130ENST00000408995UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000540130ENST00000409177UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000540130ENST00000409807UXS1chr2

106739425

-FHL2chr2

106002997

-
5CDS-5UTRENST00000540130ENST00000607522UXS1chr2

106739425

-FHL2chr2

106002997

-
5UTR-5UTRENST00000540130ENST00000322142UXS1chr2

106810603

-FHL2chr2

106002997

-
5UTR-5UTRENST00000540130ENST00000336660UXS1chr2

106810603

-FHL2chr2

106002997

-
5UTR-5UTRENST00000540130ENST00000344213UXS1chr2

106810603

-FHL2chr2

106002997

-
5UTR-5UTRENST00000540130ENST00000358129UXS1chr2

106810603

-FHL2chr2

106002997

-
5UTR-5UTRENST00000540130ENST00000393352UXS1chr2

106810603

-FHL2chr2

106002997

-
5UTR-5UTRENST00000540130ENST00000393353UXS1chr2

106810603

-FHL2chr2

106002997

-
5UTR-5UTRENST00000540130ENST00000408995UXS1chr2

106810603

-FHL2chr2

106002997

-
5UTR-5UTRENST00000540130ENST00000409177UXS1chr2

106810603

-FHL2chr2

106002997

-
5UTR-5UTRENST00000540130ENST00000409807UXS1chr2

106810603

-FHL2chr2

106002997

-
5UTR-5UTRENST00000540130ENST00000607522UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000409032ENST00000322142UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000409032ENST00000336660UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000409032ENST00000344213UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000409032ENST00000358129UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000409032ENST00000393352UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000409032ENST00000393353UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000409032ENST00000408995UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000409032ENST00000409177UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000409032ENST00000409807UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000409032ENST00000607522UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000322142UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000322142UXS1chr2

106739425

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000336660UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000336660UXS1chr2

106739425

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000344213UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000344213UXS1chr2

106739425

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000358129UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000358129UXS1chr2

106739425

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000393352UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000393352UXS1chr2

106739425

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000393353UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000393353UXS1chr2

106739425

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000408995UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000408995UXS1chr2

106739425

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000409177UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000409177UXS1chr2

106739425

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000409807UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000409807UXS1chr2

106739425

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000607522UXS1chr2

106810603

-FHL2chr2

106002997

-
intron-5UTRENST00000479621ENST00000607522UXS1chr2

106739425

-FHL2chr2

106002997

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for UXS1-FHL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UXS1-FHL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:106739425/:106002997)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FHL2

Q14192

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468, ECO:0000269|PubMed:28717008}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for UXS1-FHL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for UXS1-FHL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UXS1-FHL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UXS1-FHL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource