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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:VAPA-RAB31 (FusionGDB2 ID:97882)

Fusion Gene Summary for VAPA-RAB31

Fusion gene summary

Fusion gene information	Fusion gene name: VAPA-RAB31
	Fusion gene ID: 97882
		Hgene	Tgene
	Gene symbol	VAPA	RAB31
	Gene ID	9218	11031
	Gene name	VAMP associated protein A	RAB31, member RAS oncogene family
	Synonyms	VAP-33\|VAP-A\|VAP33\|hVAP-33	Rab22B
	Cytomap	18p11.22	18p11.22
	Type of gene	protein-coding	protein-coding
	Description	vesicle-associated membrane protein-associated protein A33 kDa VAMP-associated proteinVAMP (vesicle-associated membrane protein)-associated protein A, 33kDaVAMP-Aepididymis secretory sperm binding protein	ras-related protein Rab-31ras-related protein Rab-22B
	Modification date	20200327	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000584796, ENST00000340541, ENST00000400000,	ENST00000578921, ENST00000577284,
Fusion gene scores	* DoF score	9 X 4 X 7=252	12 X 14 X 6=1008
	# samples	10	15
	** MAII score	log2(10/252*10)=-1.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1008*10)=-2.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: VAPA [Title/Abstract] AND RAB31 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	VAPA(9937063)-RAB31(9775275), # samples:2
Anticipated loss of major functional domain due to fusion event.	VAPA-RAB31 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. VAPA-RAB31 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	VAPA	GO:0044791	positive regulation by host of viral release from host cell	19515777
Hgene	VAPA	GO:0044828	negative regulation by host of viral genome replication	19515777
Hgene	VAPA	GO:0044829	positive regulation by host of viral genome replication	19515777

Fusion gene breakpoints across VAPA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAB31 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-ZP-A9D0-01A	VAPA	chr18	9937063	-	RAB31	chr18	9775275	+
ChimerDB4	LIHC	TCGA-ZP-A9D0-01A	VAPA	chr18	9937063	+	RAB31	chr18	9775275	+
ChimerDB4	STAD	TCGA-IN-7808-01A	VAPA	chr18	9914332	+	RAB31	chr18	9845579	+

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Fusion Gene ORF analysis for VAPA-RAB31

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000584796	ENST00000578921	VAPA	chr18	9937063	+	RAB31	chr18	9775275	+
3UTR-intron	ENST00000584796	ENST00000577284	VAPA	chr18	9937063	+	RAB31	chr18	9775275	+
5CDS-intron	ENST00000340541	ENST00000577284	VAPA	chr18	9937063	+	RAB31	chr18	9775275	+
5CDS-intron	ENST00000340541	ENST00000577284	VAPA	chr18	9914332	+	RAB31	chr18	9845579	+
5CDS-intron	ENST00000400000	ENST00000577284	VAPA	chr18	9937063	+	RAB31	chr18	9775275	+
5CDS-intron	ENST00000400000	ENST00000577284	VAPA	chr18	9914332	+	RAB31	chr18	9845579	+
Frame-shift	ENST00000340541	ENST00000578921	VAPA	chr18	9914332	+	RAB31	chr18	9845579	+
Frame-shift	ENST00000400000	ENST00000578921	VAPA	chr18	9914332	+	RAB31	chr18	9845579	+
In-frame	ENST00000340541	ENST00000578921	VAPA	chr18	9937063	+	RAB31	chr18	9775275	+
In-frame	ENST00000400000	ENST00000578921	VAPA	chr18	9937063	+	RAB31	chr18	9775275	+
intron-3CDS	ENST00000584796	ENST00000578921	VAPA	chr18	9914332	+	RAB31	chr18	9845579	+
intron-intron	ENST00000584796	ENST00000577284	VAPA	chr18	9914332	+	RAB31	chr18	9845579	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000400000

VAPA

chr18

9937063

ENST00000578921

RAB31

chr18

9775275

4447

672

255

1220

321

ENST00000340541

VAPA

chr18

9937063

ENST00000578921

RAB31

chr18

9775275

4387

612

195

1160

321

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000400000	ENST00000578921	VAPA	chr18	9937063	+	RAB31	chr18	9775275	+	0.000379857	0.9996201
ENST00000340541	ENST00000578921	VAPA	chr18	9937063	+	RAB31	chr18	9775275	+	0.000371084	0.9996289

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Fusion Genomic Features for VAPA-RAB31

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
VAPA	chr18	9937063	+	RAB31	chr18	9775274	+	0.000557306	0.99944264
VAPA	chr18	9914332	+	RAB31	chr18	9845578	+	4.99E-12	1
VAPA	chr18	9937063	+	RAB31	chr18	9775274	+	0.000557306	0.99944264
VAPA	chr18	9914332	+	RAB31	chr18	9845578	+	4.99E-12	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VAPA-RAB31

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:9937063/chr18:9775275)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VAPA

chr18:9937063

chr18:9775275

ENST00000340541

14_131

139

295.0

Domain

MSP

Hgene

VAPA

chr18:9937063

chr18:9775275

ENST00000400000

14_131

139

250.0

Domain

MSP

Tgene

RAB31

chr18:9937063

chr18:9775275

ENST00000578921

34_42

196.0

Motif

Effector region

Tgene

RAB31

chr18:9937063

chr18:9775275

ENST00000578921

118_121

196.0

Nucleotide binding

Note=GTP

Tgene

RAB31

chr18:9937063

chr18:9775275

ENST00000578921

12_19

196.0

Nucleotide binding

Note=GTP

Tgene

RAB31

chr18:9937063

chr18:9775275

ENST00000578921

60_64

196.0

Nucleotide binding

Note=GTP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VAPA

chr18:9937063

chr18:9775275

ENST00000340541

169_205

139

295.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

VAPA

chr18:9937063

chr18:9775275

ENST00000400000

169_205

139

250.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

VAPA

chr18:9937063

chr18:9775275

ENST00000340541

2_227

139

295.0

Topological domain

Cytoplasmic

Hgene

VAPA

chr18:9937063

chr18:9775275

ENST00000400000

2_227

139

250.0

Topological domain

Cytoplasmic

Hgene

VAPA

chr18:9937063

chr18:9775275

ENST00000340541

228_248

139

295.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Hgene

VAPA

chr18:9937063

chr18:9775275

ENST00000400000

228_248

139

250.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

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Fusion Gene Sequence for VAPA-RAB31

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>97882_97882_1_VAPA-RAB31_VAPA_chr18_9937063_ENST00000340541_RAB31_chr18_9775275_ENST00000578921_length(transcript)=4387nt_BP=612nt
TCAGTTGTGGGACCCGGAGCTGCTGACCCAGCGGGTGGCCCACCGAACCGGTGACACAGCGGCAGGCGTTAGGGCTCGGGAGCCGCGAGC
CTGGCCTCGTCCTAGAGCTCGGCCGAGCCGTCGCCGCCGTCGTCCCCCGCCCCCAGTCAGCAAACCGCCGCCGCGGGCGCGCCCCCGCTC
TGCGCTGTCTCTCCGATGGCGTCCGCCTCAGGGGCCATGGCGAAGCACGAGCAGATCCTGGTCCTCGATCCGCCCACAGACCTCAAATTC
AAAGGCCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCA
CCTCGCCGGTACTGTGTGAGGCCCAACAGTGGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTAT
GATCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAG
GCAAAACCTGATGAATTAATGGATTCCAAATTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGGACACTGGGGTTGGGAAA
TCAAGCATCGTGTGTCGATTTGTCCAGGATCACTTTGACCACAACATCAGCCCTACTATTGGGGCATCTTTTATGACCAAAACTGTGCCT
TGTGGAAATGAACTTCACAAGTTCCTCATCTGGGACACTGCTGGTCAGGAACGGTTTCATTCATTGGCTCCCATGTACTATCGAGGCTCA
GCTGCAGCTGTTATCGTGTATGATATTACCAAGCAGGATTCATTTTATACCTTGAAGAAATGGGTCAAGGAGCTGAAAGAACATGGTCCA
GAAAACATTGTAATGGCCATCGCTGGAAACAAGTGCGACCTCTCAGATATTAGGGAGGTTCCCCTGAAGGATGCTAAGGAATACGCTGAA
TCCATAGGTGCCATCGTGGTTGAGACAAGTGCAAAAAATGCTATTAATATCGAAGAGCTCTTTCAAGGAATCAGCCGCCAGATCCCACCC
TTGGACCCCCATGAAAATGGAAACAATGGAACAATCAAAGTTGAGAAGCCAACCATGCAAGCCAGCCGCCGGTGCTGTTGACCCAAGGGC
CGTGGTCCACGGTACTTGAAGAAGCCAGAGCCCACATCCTGTGCACTGCTGAAGGACCCTACGCTCGGTGGCCTGGCACCTCACTTTGAG
AAGAGTGAGCACACTGGCTTTGCATCCTGGAAGACCTGCAGGGGGCGGGGCAGGAAATGTACCTGAAAAGGATTTTAGAAAACCCTGGGA
AAACCCACCACACCACCACAAAATGGCCTTTAGTGTATGAAATGCACATGGAGGGGATGTAGTTGCATTTTTGCTAAAAAAAAAAAAAAA
CCTTTAAAAATTGTTGGATGTGTACAAAAGTCTTACTGCCTTATTATGTGTATGGGATTCTAAAGTGGCATTCCACTTGGATTTCCTGTG
CTACCTATCCAAATTCCAGTAACTACTTCAGTGTCATTGCCTTTGTTACCTAACCAACCTTCACTGAAAGGCAAATTTAGTTCAGGAGGT
TAGTTTTTAGCTAGCTTTGGAAGTAAGCCTTTATTTATTACTTTTTGGAGGAAATCAGAGAAGTGTCAATGGACCGTCACTCAGACTGAG
ACTTGAGTTATTACAGAAGCCAGGAAAAGTGTATTAGAAACTGTTGTCTACACCACTTTTAATTGGTGAACAATTTTTCTAAGTTATGGT
CATATATACCCAAACAAACCAAATCAAACTAAATTACTGCATATAATTTTGGGATTGGGTGGCCTAGTTTGAAAGAGTGATTTAAGTAAT
CACTATGTAAGTGGTGAGAGATGCAGGACATACACATTATTCAAGAGACCACCTGACATGCATCTCCTCCGCAGGAATACATTCGTCCTC
TCTTAGAGAAGTTTAACGCACATAGTATTATTTTACTAAGAGAATATCTCTTGGTGTCATATCTAGGGGAAGAGAATTAACTAGAATTAA
ATTTAATGTTTGAATCTAAATCATTGGGCAAACTTCTAATAATAACAATTAATAATAGGTTACAGGAAAGCCAGCCAGAGGAAGTGTCAG
CACTTTAAAATTCTAGACCCCAAAAAACTACAAAATCAGAAAAAGTATTTTTATGTTTCTAGCTTGAGGAGAAGGGCTTTAGGGCTAACC
AGAGGTCTGACCCTAGAATGCCAAGGAACTGAGAATGGGCTCCGATGAAAACCTTCCTTTTCAGATTCCCTGTCTGCTCAATTAAAGATG
TTTGAATCCAAAGGAAGTCAAGGAAGAAAAAGCATGGAAAGGAAGAGAACTGATTCCTACTGAAAATTCAAATTCTATTACCATTCTAAC
TTTCATAAAAAGTTGGGATCAAGAAGCAGCTGATTTCCTGCCAGGGCTTATATTAGGGGGTGATTCTTAAAGGACATTAGGATTGGTGCT
CAGAAATGGTTAATCATGCTGTGTGCTAGCCAGGGCCAGCTGGTACCTTCTTTGCCATGAGCATTCAAGGGACGGCTAACCTTTATTGAC
AATCTATATCGCAAAAGTCAGGAAAGAGGTTGTGAGCTGATTGGATTAAAGACCTGGCACTTCAGTAACTCAGCACGCTTCCACTTCACT
CAACTTAAGAGAGTTCATTGACAGTGTTAGGATGTGAAGGCTGGGAAACACTTATTTTGCTTCAAGAGTTCCACTTGGCTCTCCCAAATA
GGTACCTCAAAAACTGTTAGCAAGCGGCATTTGGATGTCTTGACAGGGGCTTTGCAGGGATTTTTAGGGTTTTTTCCACATTGTCCACAT
TAATGGTTGGCATGATTGTGCTTGCAGGCCAAGAAATGATCATACCCCTTGCCAAAGGTAAAAAAAAAAAAAAAAAAATGAGTTGAAAAT
TGAAGTGACCTCTTTCCAGCTGAGTTGCAGGCTTATTTTGTAACCTTTCCTCATCCAGTTTTCCCTGAGAACCTGGGTTTATCTCTAGAT
AGCTGTTCAGGTTTTTTAGCTGAGGGGTAAGTATCCTAGCTGAGAGTTTTGCATCTTTGGGCTGGGTTTGCAGTGGTTGTGTTTTGCATA
AAATGTCTAGTCTTTGCCACAGATAGTGAGCTACCCACTAATGAGCCCATGGTTTTATTTCAGAAGCACATGAGGGTGTGAAACCACTCT
GTTACCTTTCTGTATTGTCTTAGCTATTCAAGCCAGTCAGAGGATAATATATATATTCTCATCAGCACTCAGAGTAGTCAGTGAAGAGAG
TAGATCACACTTGGGCACACCAGGATTCACATAAACATTGTATCTTCTCTGTGGATGCTCAGGCCTTGTCTACAATGAGGCTTTACAACC
TTCCTTTGTTTTGGCTCGGGATTACTTCCTGGCTGTCTAATAATTGAACCATAACCATGTAATATTATGTAAAGGCCTGGAAATTACTGT
TGCTAAAAAAAGTCATGTAGTTTCATGTAGTGTAGCATCCTTGGCATCGTTTTCCAAAATTTGTTCCTTCTCCCTTTTTTTTTTCTTTCG
TGTGTGGCATGAGTGTGTATCTGTGTAAATATGATTGTATATGTGTTACTCCGATATGTAATCCATTTCACTGGCTGAGTTTGGCCCCTA
GCCATGTGTTAATATAAAGTAGGCATGGCTTCCCAATGGAAATCTCTGAGAATGACAGTGGAGTTGTGCAAGCATTTTACATTGCCACAT
AATTGACTTGCCATTTTATGGTTAAAAACGGCACATTAGGCAGTTGAATATGACGTTACCTTGCAGACTAAAAGGTTGAAGGCCCGAAAC
TAACTTTTAGCTAACAATAAGGGCTGTGCCCCAATGGAAACTGAGTTCATTTTCTGAGAAAGGTTTGGATGACTGAAATATTTCCTCTAC
AGTCAAGGACTTTGGCATGTGGTGGCTGAAACTGAGCTTTTTTGTGTGGGCTCCAGTTCTCACTGTTCTGCAATGCTCATGGCAAGTTGA
ATGGTGAGCTAGCTTATAAATTAAAGAGCTCTGAACTGTATTCAGACCGACTGGGTATCTAGCTTACTGTTTTAACATCATTGTTGAAAC
CAGACCCTGTAGTCCAGTGGTGCTGCCCTGTTGTGCAAACTGCTCCTTTTTCTCGTGTTTTTGTAAAGAGCTTCCATCTGGGCTGGACCC
AGTTCTTGCACATACAAGACACCGCTGCAGTCAGCTAGGACCTTTCCGCCATGTATTCTATTCTGTAGTAAAGCATTTCCATCAACAATG

>97882_97882_1_VAPA-RAB31_VAPA_chr18_9937063_ENST00000340541_RAB31_chr18_9775275_ENST00000578921_length(amino acids)=321AA_BP=139
MASASGAMAKHEQILVLDPPTDLKFKGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEK
SKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNEL
HKFLIWDTAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIREVPLKDAKEYAESIGAI

--------------------------------------------------------------
>97882_97882_2_VAPA-RAB31_VAPA_chr18_9937063_ENST00000400000_RAB31_chr18_9775275_ENST00000578921_length(transcript)=4447nt_BP=672nt
TCACGTGGGTCGCCGAGGCTCGCAAGTGCGCGTGGCCGTGGCGGCTGGTGTGGGGTTGAGTCAGTTGTGGGACCCGGAGCTGCTGACCCA
GCGGGTGGCCCACCGAACCGGTGACACAGCGGCAGGCGTTAGGGCTCGGGAGCCGCGAGCCTGGCCTCGTCCTAGAGCTCGGCCGAGCCG
TCGCCGCCGTCGTCCCCCGCCCCCAGTCAGCAAACCGCCGCCGCGGGCGCGCCCCCGCTCTGCGCTGTCTCTCCGATGGCGTCCGCCTCA
GGGGCCATGGCGAAGCACGAGCAGATCCTGGTCCTCGATCCGCCCACAGACCTCAAATTCAAAGGCCCCTTCACAGATGTAGTCACTACA
AATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTCGCCGGTACTGTGTGAGGCCCAACAGT
GGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGATCCGAATGAAAAGAGTAAACACAAGTTT
ATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAAAACCTGATGAATTAATGGATTCCAAA
TTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGGACACTGGGGTTGGGAAATCAAGCATCGTGTGTCGATTTGTCCAGGAT
CACTTTGACCACAACATCAGCCCTACTATTGGGGCATCTTTTATGACCAAAACTGTGCCTTGTGGAAATGAACTTCACAAGTTCCTCATC
TGGGACACTGCTGGTCAGGAACGGTTTCATTCATTGGCTCCCATGTACTATCGAGGCTCAGCTGCAGCTGTTATCGTGTATGATATTACC
AAGCAGGATTCATTTTATACCTTGAAGAAATGGGTCAAGGAGCTGAAAGAACATGGTCCAGAAAACATTGTAATGGCCATCGCTGGAAAC
AAGTGCGACCTCTCAGATATTAGGGAGGTTCCCCTGAAGGATGCTAAGGAATACGCTGAATCCATAGGTGCCATCGTGGTTGAGACAAGT
GCAAAAAATGCTATTAATATCGAAGAGCTCTTTCAAGGAATCAGCCGCCAGATCCCACCCTTGGACCCCCATGAAAATGGAAACAATGGA
ACAATCAAAGTTGAGAAGCCAACCATGCAAGCCAGCCGCCGGTGCTGTTGACCCAAGGGCCGTGGTCCACGGTACTTGAAGAAGCCAGAG
CCCACATCCTGTGCACTGCTGAAGGACCCTACGCTCGGTGGCCTGGCACCTCACTTTGAGAAGAGTGAGCACACTGGCTTTGCATCCTGG
AAGACCTGCAGGGGGCGGGGCAGGAAATGTACCTGAAAAGGATTTTAGAAAACCCTGGGAAAACCCACCACACCACCACAAAATGGCCTT
TAGTGTATGAAATGCACATGGAGGGGATGTAGTTGCATTTTTGCTAAAAAAAAAAAAAAACCTTTAAAAATTGTTGGATGTGTACAAAAG
TCTTACTGCCTTATTATGTGTATGGGATTCTAAAGTGGCATTCCACTTGGATTTCCTGTGCTACCTATCCAAATTCCAGTAACTACTTCA
GTGTCATTGCCTTTGTTACCTAACCAACCTTCACTGAAAGGCAAATTTAGTTCAGGAGGTTAGTTTTTAGCTAGCTTTGGAAGTAAGCCT
TTATTTATTACTTTTTGGAGGAAATCAGAGAAGTGTCAATGGACCGTCACTCAGACTGAGACTTGAGTTATTACAGAAGCCAGGAAAAGT
GTATTAGAAACTGTTGTCTACACCACTTTTAATTGGTGAACAATTTTTCTAAGTTATGGTCATATATACCCAAACAAACCAAATCAAACT
AAATTACTGCATATAATTTTGGGATTGGGTGGCCTAGTTTGAAAGAGTGATTTAAGTAATCACTATGTAAGTGGTGAGAGATGCAGGACA
TACACATTATTCAAGAGACCACCTGACATGCATCTCCTCCGCAGGAATACATTCGTCCTCTCTTAGAGAAGTTTAACGCACATAGTATTA
TTTTACTAAGAGAATATCTCTTGGTGTCATATCTAGGGGAAGAGAATTAACTAGAATTAAATTTAATGTTTGAATCTAAATCATTGGGCA
AACTTCTAATAATAACAATTAATAATAGGTTACAGGAAAGCCAGCCAGAGGAAGTGTCAGCACTTTAAAATTCTAGACCCCAAAAAACTA
CAAAATCAGAAAAAGTATTTTTATGTTTCTAGCTTGAGGAGAAGGGCTTTAGGGCTAACCAGAGGTCTGACCCTAGAATGCCAAGGAACT
GAGAATGGGCTCCGATGAAAACCTTCCTTTTCAGATTCCCTGTCTGCTCAATTAAAGATGTTTGAATCCAAAGGAAGTCAAGGAAGAAAA
AGCATGGAAAGGAAGAGAACTGATTCCTACTGAAAATTCAAATTCTATTACCATTCTAACTTTCATAAAAAGTTGGGATCAAGAAGCAGC
TGATTTCCTGCCAGGGCTTATATTAGGGGGTGATTCTTAAAGGACATTAGGATTGGTGCTCAGAAATGGTTAATCATGCTGTGTGCTAGC
CAGGGCCAGCTGGTACCTTCTTTGCCATGAGCATTCAAGGGACGGCTAACCTTTATTGACAATCTATATCGCAAAAGTCAGGAAAGAGGT
TGTGAGCTGATTGGATTAAAGACCTGGCACTTCAGTAACTCAGCACGCTTCCACTTCACTCAACTTAAGAGAGTTCATTGACAGTGTTAG
GATGTGAAGGCTGGGAAACACTTATTTTGCTTCAAGAGTTCCACTTGGCTCTCCCAAATAGGTACCTCAAAAACTGTTAGCAAGCGGCAT
TTGGATGTCTTGACAGGGGCTTTGCAGGGATTTTTAGGGTTTTTTCCACATTGTCCACATTAATGGTTGGCATGATTGTGCTTGCAGGCC
AAGAAATGATCATACCCCTTGCCAAAGGTAAAAAAAAAAAAAAAAAAATGAGTTGAAAATTGAAGTGACCTCTTTCCAGCTGAGTTGCAG
GCTTATTTTGTAACCTTTCCTCATCCAGTTTTCCCTGAGAACCTGGGTTTATCTCTAGATAGCTGTTCAGGTTTTTTAGCTGAGGGGTAA
GTATCCTAGCTGAGAGTTTTGCATCTTTGGGCTGGGTTTGCAGTGGTTGTGTTTTGCATAAAATGTCTAGTCTTTGCCACAGATAGTGAG
CTACCCACTAATGAGCCCATGGTTTTATTTCAGAAGCACATGAGGGTGTGAAACCACTCTGTTACCTTTCTGTATTGTCTTAGCTATTCA
AGCCAGTCAGAGGATAATATATATATTCTCATCAGCACTCAGAGTAGTCAGTGAAGAGAGTAGATCACACTTGGGCACACCAGGATTCAC
ATAAACATTGTATCTTCTCTGTGGATGCTCAGGCCTTGTCTACAATGAGGCTTTACAACCTTCCTTTGTTTTGGCTCGGGATTACTTCCT
GGCTGTCTAATAATTGAACCATAACCATGTAATATTATGTAAAGGCCTGGAAATTACTGTTGCTAAAAAAAGTCATGTAGTTTCATGTAG
TGTAGCATCCTTGGCATCGTTTTCCAAAATTTGTTCCTTCTCCCTTTTTTTTTTCTTTCGTGTGTGGCATGAGTGTGTATCTGTGTAAAT
ATGATTGTATATGTGTTACTCCGATATGTAATCCATTTCACTGGCTGAGTTTGGCCCCTAGCCATGTGTTAATATAAAGTAGGCATGGCT
TCCCAATGGAAATCTCTGAGAATGACAGTGGAGTTGTGCAAGCATTTTACATTGCCACATAATTGACTTGCCATTTTATGGTTAAAAACG
GCACATTAGGCAGTTGAATATGACGTTACCTTGCAGACTAAAAGGTTGAAGGCCCGAAACTAACTTTTAGCTAACAATAAGGGCTGTGCC
CCAATGGAAACTGAGTTCATTTTCTGAGAAAGGTTTGGATGACTGAAATATTTCCTCTACAGTCAAGGACTTTGGCATGTGGTGGCTGAA
ACTGAGCTTTTTTGTGTGGGCTCCAGTTCTCACTGTTCTGCAATGCTCATGGCAAGTTGAATGGTGAGCTAGCTTATAAATTAAAGAGCT
CTGAACTGTATTCAGACCGACTGGGTATCTAGCTTACTGTTTTAACATCATTGTTGAAACCAGACCCTGTAGTCCAGTGGTGCTGCCCTG
TTGTGCAAACTGCTCCTTTTTCTCGTGTTTTTGTAAAGAGCTTCCATCTGGGCTGGACCCAGTTCTTGCACATACAAGACACCGCTGCAG
TCAGCTAGGACCTTTCCGCCATGTATTCTATTCTGTAGTAAAGCATTTCCATCAACAATGCCTAATTGTATCTGTTATTTTTGGTTTAAC

>97882_97882_2_VAPA-RAB31_VAPA_chr18_9937063_ENST00000400000_RAB31_chr18_9775275_ENST00000578921_length(amino acids)=321AA_BP=139
MASASGAMAKHEQILVLDPPTDLKFKGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEK
SKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNEL
HKFLIWDTAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIREVPLKDAKEYAESIGAI

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Fusion Gene PPI Analysis for VAPA-RAB31

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for VAPA-RAB31

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for VAPA-RAB31

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source