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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:VASH1-PRKCH (FusionGDB2 ID:97903)

Fusion Gene Summary for VASH1-PRKCH

Fusion gene summary

Fusion gene information	Fusion gene name: VASH1-PRKCH
	Fusion gene ID: 97903
		Hgene	Tgene
	Gene symbol	VASH1	PRKCH
	Gene ID	22846	5583
	Gene name	vasohibin 1	protein kinase C eta
	Synonyms	KIAA1036\|TTCP 1	PKC-L\|PKCL\|PRKCL\|nPKC-eta
	Cytomap	14q24.3	14q23.1
	Type of gene	protein-coding	protein-coding
	Description	tubulinyl-Tyr carboxypeptidase 1tubulin carboxypeptidase 1tyrosine carboxypeptidase 1	protein kinase C eta type
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000167106, ENST00000554237, ENST00000554743, ENST00000556038,	ENST00000556245, ENST00000332981, ENST00000555082,
Fusion gene scores	* DoF score	3 X 3 X 1=9	17 X 18 X 11=3366
	# samples	3	27
	** MAII score	log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(27/3366*10)=-3.64000386427912 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: VASH1 [Title/Abstract] AND PRKCH [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	VASH1(77229474)-PRKCH(61952218), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	VASH1	GO:0001525	angiogenesis	15467828
Hgene	VASH1	GO:0001937	negative regulation of endothelial cell proliferation	15467828\|19204325
Hgene	VASH1	GO:0006508	proteolysis	29146869
Hgene	VASH1	GO:0009611	response to wounding	23056314
Hgene	VASH1	GO:0016525	negative regulation of angiogenesis	15467828
Hgene	VASH1	GO:0043537	negative regulation of blood vessel endothelial cell migration	15467828

Fusion gene breakpoints across VASH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PRKCH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	DA951876	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+

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Fusion Gene ORF analysis for VASH1-PRKCH

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000167106	ENST00000556245	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+
5CDS-intron	ENST00000554237	ENST00000556245	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+
In-frame	ENST00000167106	ENST00000332981	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+
In-frame	ENST00000167106	ENST00000555082	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+
In-frame	ENST00000554237	ENST00000332981	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+
In-frame	ENST00000554237	ENST00000555082	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+
intron-3CDS	ENST00000554743	ENST00000332981	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+
intron-3CDS	ENST00000554743	ENST00000555082	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+
intron-3CDS	ENST00000556038	ENST00000332981	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+
intron-3CDS	ENST00000556038	ENST00000555082	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+
intron-intron	ENST00000554743	ENST00000556245	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+
intron-intron	ENST00000556038	ENST00000556245	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000167106

VASH1

chr14

77229474

ENST00000332981

PRKCH

chr14

61952218

2861

942

633

1715

360

ENST00000167106

VASH1

chr14

77229474

ENST00000555082

PRKCH

chr14

61952218

2861

942

633

1715

360

ENST00000554237

VASH1

chr14

77229474

ENST00000332981

PRKCH

chr14

61952218

2721

802

493

1575

360

ENST00000554237

VASH1

chr14

77229474

ENST00000555082

PRKCH

chr14

61952218

2721

802

493

1575

360

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000167106	ENST00000332981	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+	0.000935166	0.99906486
ENST00000167106	ENST00000555082	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+	0.000935166	0.99906486
ENST00000554237	ENST00000332981	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+	0.000888749	0.99911124
ENST00000554237	ENST00000555082	VASH1	chr14	77229474	+	PRKCH	chr14	61952218	+	0.000888749	0.99911124

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Fusion Genomic Features for VASH1-PRKCH

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
VASH1	chr14	77229473	+	PRKCH	chr14	61952219	+	4.20E-06	0.9999958
VASH1	chr14	77229473	+	PRKCH	chr14	61952219	+	4.20E-06	0.9999958

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VASH1-PRKCH

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:77229474/chr14:61952218)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PRKCH

chr14:77229474

chr14:61952218

ENST00000332981

615_683

426

684.0

Domain

AGC-kinase C-terminal

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VASH1

chr14:77229474

chr14:61952218

ENST00000167106

319_365

103

366.0

Region

Involved in heparin-binding and antiangiogenic activity

Hgene

VASH1

chr14:77229474

chr14:61952218

ENST00000554237

319_365

103

205.0

Region

Involved in heparin-binding and antiangiogenic activity

Tgene

PRKCH

chr14:77229474

chr14:61952218

ENST00000332981

1_118

426

684.0

Domain

Tgene

PRKCH

chr14:77229474

chr14:61952218

ENST00000332981

355_614

426

684.0

Domain

Protein kinase

Tgene

PRKCH

chr14:77229474

chr14:61952218

ENST00000332981

361_369

426

684.0

Nucleotide binding

ATP

Tgene

PRKCH

chr14:77229474

chr14:61952218

ENST00000332981

171_222

426

684.0

Zinc finger

Phorbol-ester/DAG-type 1

Tgene

PRKCH

chr14:77229474

chr14:61952218

ENST00000332981

245_295

426

684.0

Zinc finger

Phorbol-ester/DAG-type 2

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Fusion Gene Sequence for VASH1-PRKCH

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>97903_97903_1_VASH1-PRKCH_VASH1_chr14_77229474_ENST00000167106_PRKCH_chr14_61952218_ENST00000332981_length(transcript)=2861nt_BP=942nt
GCTCCCGGCCAGCTGCGAGTCTTGGCTCCCGGACTTGTCTCGTCGCGTCGGAGAAATCGCCCCCCAGCGCCGCTCTCCCGCCCGGGGGTC
TTGGTTCCGAGCTCGCGCGGCCGGGAGTCGCCTCGGTCTTCCTTGGGGCGCGCGCAGATGTGAGCGTGCGAGAGTTGTGTAGGGGATTTT
GTTCCCTCCGAAACTGAGACCCAGGGCGCCCAGTGGGCACCCGTGCCTTGACTCTGTCCTTTCTGCAGCCGCTGGTCCGAGCTGTCTGGC
CTCAGTTTCCCTCCGACTTTTCTCCGCTCTGCCAGCCCTCACTGCTGCCCGTCATTGTTCTCGCAGTTAGATGGGGGTGCTTTGTGACGG
CTGCCAAGTTGGGGTGTGTTCTCTTTATTCCGTTTTTCAAACAGAACAAGGCCTCCAAGGCTGACCCCAGACAACCCACCCCCTCGGACC
CTAATTCACCTTATTGCACTGATTTTTTTTATCAAGTCGTATTTTATTGTACAGGAGCCACGCCCTGATTTCTTAAAGGCGCCTTGCACT
CTGGCCATGTGTTATCTCTGCAGCCGGTGTGTGGGAGGCCTCTTGTGAGCCAGTTGTTTTCCCGCCTCCACCACCCCCCTCGAAGATTTA
GGGATGCCAGGGGGGAAGAAGGTGGCTGGGGGTGGCAGCAGCGGTGCCACTCCAACGTCCGCTGCGGCCACCGCCCCCTCTGGGGTCAGG
CGTTTGGAGACCAGCGAAGGAACCTCAGCCCAGAGAGATGAGGAGCCAGAAGAGGAAGGGGAAGAGGACCTGCGAGACGGAGGCGTCCCC
TTCTTTGTCAACCGGGGTGGGCTACCTGTGGATGAGGCCACCTGGGAAAGGATGTGGAAACACGTGGCCAAGATCCACCCCGATGGAGAG
AAGGTGGCGCAACGGATCCGTGGGGCCACAGACCTGCCCAAGGATCGTCTGTTTTTTGTGATGGAGTTTGTGAATGGGGGTGACTTGATG
TTCCACATTCAGAAGTCTCGTCGTTTTGATGAAGCACGAGCTCGCTTCTATGCTGCAGAAATCATTTCGGCTCTCATGTTCCTCCATGAT
AAAGGAATCATCTATAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAAG
GAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGGG
CCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCTC
TTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACCAAGAAC
CCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTG
AACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGAG
CCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAATTGCAA
CCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGAGATTCTCCAGGAATTTCCTCTATGGGACCTTCCCAGC
ATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTGAAGGATGGAACTTTCAGATATCAACTATTTAGAGTCC
AGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAGTATACCGCTCCACCTATGAGCGTCTGTCTCTGTGGGC
TTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGATCTGAGAAATTCTGAGCCAATCAGGCTTCTTAATTCAA
GAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATGAACCCCAATTCCTGGCAGTCTACAAGAAGTCTCTTAA
TGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATAGAATGATTTACTCTGAAGAAACAAACAATGGTATCTC
TGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGACTGCTTCAGCTTCTTCTCTTATCCTTACTTTCTTTAA
TAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTAAACAACAGGTTTGCATTCATGAAGCTTTCATTCATTC
TGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCCACGTTGCATATGTCACACTTTTGTCTGCACATAACTC
TTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTACAGGTGCCTGCTGCCTGCCTACCTGGGTAATCTGATCT
TGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAGTGACCAGATTTGTGGCTTATAAACATTAGCAGTTTAT
TTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAAATGGATCTTGTAAACAGGGCATATATCAAAGATGACC

>97903_97903_1_VASH1-PRKCH_VASH1_chr14_77229474_ENST00000167106_PRKCH_chr14_61952218_ENST00000332981_length(amino acids)=360AA_BP=103
MPGGKKVAGGGSSGATPTSAAATAPSGVRRLETSEGTSAQRDEEPEEEGEEDLRDGGVPFFVNRGGLPVDEATWERMWKHVAKIHPDGEK
VAQRIRGATDLPKDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKE
GICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNP
TMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQP

--------------------------------------------------------------
>97903_97903_2_VASH1-PRKCH_VASH1_chr14_77229474_ENST00000167106_PRKCH_chr14_61952218_ENST00000555082_length(transcript)=2861nt_BP=942nt
GCTCCCGGCCAGCTGCGAGTCTTGGCTCCCGGACTTGTCTCGTCGCGTCGGAGAAATCGCCCCCCAGCGCCGCTCTCCCGCCCGGGGGTC
TTGGTTCCGAGCTCGCGCGGCCGGGAGTCGCCTCGGTCTTCCTTGGGGCGCGCGCAGATGTGAGCGTGCGAGAGTTGTGTAGGGGATTTT
GTTCCCTCCGAAACTGAGACCCAGGGCGCCCAGTGGGCACCCGTGCCTTGACTCTGTCCTTTCTGCAGCCGCTGGTCCGAGCTGTCTGGC
CTCAGTTTCCCTCCGACTTTTCTCCGCTCTGCCAGCCCTCACTGCTGCCCGTCATTGTTCTCGCAGTTAGATGGGGGTGCTTTGTGACGG
CTGCCAAGTTGGGGTGTGTTCTCTTTATTCCGTTTTTCAAACAGAACAAGGCCTCCAAGGCTGACCCCAGACAACCCACCCCCTCGGACC
CTAATTCACCTTATTGCACTGATTTTTTTTATCAAGTCGTATTTTATTGTACAGGAGCCACGCCCTGATTTCTTAAAGGCGCCTTGCACT
CTGGCCATGTGTTATCTCTGCAGCCGGTGTGTGGGAGGCCTCTTGTGAGCCAGTTGTTTTCCCGCCTCCACCACCCCCCTCGAAGATTTA
GGGATGCCAGGGGGGAAGAAGGTGGCTGGGGGTGGCAGCAGCGGTGCCACTCCAACGTCCGCTGCGGCCACCGCCCCCTCTGGGGTCAGG
CGTTTGGAGACCAGCGAAGGAACCTCAGCCCAGAGAGATGAGGAGCCAGAAGAGGAAGGGGAAGAGGACCTGCGAGACGGAGGCGTCCCC
TTCTTTGTCAACCGGGGTGGGCTACCTGTGGATGAGGCCACCTGGGAAAGGATGTGGAAACACGTGGCCAAGATCCACCCCGATGGAGAG
AAGGTGGCGCAACGGATCCGTGGGGCCACAGACCTGCCCAAGGATCGTCTGTTTTTTGTGATGGAGTTTGTGAATGGGGGTGACTTGATG
TTCCACATTCAGAAGTCTCGTCGTTTTGATGAAGCACGAGCTCGCTTCTATGCTGCAGAAATCATTTCGGCTCTCATGTTCCTCCATGAT
AAAGGAATCATCTATAGAGATCTGAAACTGGACAATGTCCTGTTGGACCACGAGGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAAG
GAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGACTATATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGGG
CCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTGTGGTCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCTC
TTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGAAGATGCCACAGGGATCCTAAAATCTTTCATGACCAAGAAC
CCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTTGAGACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTG
AACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGAAGATGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGAG
CCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGATGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAATTGCAA
CCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAATAGAGATTCTCCAGGAATTTCCTCTATGGGACCTTCCCAGC
ATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCTGTGAAGGATGGAACTTTCAGATATCAACTATTTAGAGTCC
AGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATGAAGTATACCGCTCCACCTATGAGCGTCTGTCTCTGTGGGC
TTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTAGATCTGAGAAATTCTGAGCCAATCAGGCTTCTTAATTCAA
GAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCAATGAACCCCAATTCCTGGCAGTCTACAAGAAGTCTCTTAA
TGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAAATAGAATGATTTACTCTGAAGAAACAAACAATGGTATCTC
TGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGACGACTGCTTCAGCTTCTTCTCTTATCCTTACTTTCTTTAA
TAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATTGTAAACAACAGGTTTGCATTCATGAAGCTTTCATTCATTC
TGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTCTCCACGTTGCATATGTCACACTTTTGTCTGCACATAACTC
TTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAATTACAGGTGCCTGCTGCCTGCCTACCTGGGTAATCTGATCT
TGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGTCAGTGACCAGATTTGTGGCTTATAAACATTAGCAGTTTAT
TTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTAGAAATGGATCTTGTAAACAGGGCATATATCAAAGATGACC

>97903_97903_2_VASH1-PRKCH_VASH1_chr14_77229474_ENST00000167106_PRKCH_chr14_61952218_ENST00000555082_length(amino acids)=360AA_BP=103
MPGGKKVAGGGSSGATPTSAAATAPSGVRRLETSEGTSAQRDEEPEEEGEEDLRDGGVPFFVNRGGLPVDEATWERMWKHVAKIHPDGEK
VAQRIRGATDLPKDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKE
GICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNP
TMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQP

--------------------------------------------------------------
>97903_97903_3_VASH1-PRKCH_VASH1_chr14_77229474_ENST00000554237_PRKCH_chr14_61952218_ENST00000332981_length(transcript)=2721nt_BP=802nt
CGCGCAGATGTGAGCGTGCGAGAGTTGTGTAGGGGATTTTGTTCCCTCCGAAACTGAGACCCAGGGCGCCCAGTGGGCACCCGTGCCTTG
ACTCTGTCCTTTCTGCAGCCGCTGGTCCGAGCTGTCTGGCCTCAGTTTCCCTCCGACTTTTCTCCGCTCTGCCAGCCCTCACTGCTGCCC
GTCATTGTTCTCGCAGTTAGATGGGGGTGCTTTGTGACGGCTGCCAAGTTGGGGTGTGTTCTCTTTATTCCGTTTTTCAAACAGAACAAG
GCCTCCAAGGCTGACCCCAGACAACCCACCCCCTCGGACCCTAATTCACCTTATTGCACTGATTTTTTTTATCAAGTCGTATTTTATTGT
ACAGGAGCCACGCCCTGATTTCTTAAAGGCGCCTTGCACTCTGGCCATGTGTTATCTCTGCAGCCGGTGTGTGGGAGGCCTCTTGTGAGC
CAGTTGTTTTCCCGCCTCCACCACCCCCCTCGAAGATTTAGGGATGCCAGGGGGGAAGAAGGTGGCTGGGGGTGGCAGCAGCGGTGCCAC
TCCAACGTCCGCTGCGGCCACCGCCCCCTCTGGGGTCAGGCGTTTGGAGACCAGCGAAGGAACCTCAGCCCAGAGAGATGAGGAGCCAGA
AGAGGAAGGGGAAGAGGACCTGCGAGACGGAGGCGTCCCCTTCTTTGTCAACCGGGGTGGGCTACCTGTGGATGAGGCCACCTGGGAAAG
GATGTGGAAACACGTGGCCAAGATCCACCCCGATGGAGAGAAGGTGGCGCAACGGATCCGTGGGGCCACAGACCTGCCCAAGGATCGTCT
GTTTTTTGTGATGGAGTTTGTGAATGGGGGTGACTTGATGTTCCACATTCAGAAGTCTCGTCGTTTTGATGAAGCACGAGCTCGCTTCTA
TGCTGCAGAAATCATTTCGGCTCTCATGTTCCTCCATGATAAAGGAATCATCTATAGAGATCTGAAACTGGACAATGTCCTGTTGGACCA
CGAGGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGA
CTATATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTG
TGGTCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGA
AGATGCCACAGGGATCCTAAAATCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTT
GAGACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGA
AGATGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGA
TGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAAT
AGAGATTCTCCAGGAATTTCCTCTATGGGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCT
GTGAAGGATGGAACTTTCAGATATCAACTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATG
AAGTATACCGCTCCACCTATGAGCGTCTGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTA
GATCTGAGAAATTCTGAGCCAATCAGGCTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCA
ATGAACCCCAATTCCTGGCAGTCTACAAGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAA
ATAGAATGATTTACTCTGAAGAAACAAACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGA
CGACTGCTTCAGCTTCTTCTCTTATCCTTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATT
GTAAACAACAGGTTTGCATTCATGAAGCTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTC
TCCACGTTGCATATGTCACACTTTTGTCTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAAT
TACAGGTGCCTGCTGCCTGCCTACCTGGGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGT
CAGTGACCAGATTTGTGGCTTATAAACATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTA
GAAATGGATCTTGTAAACAGGGCATATATCAAAGATGACCTTATAATATGTACCCGAATATACAGTTCAAGAATTTTGTCTGACTGGAAA

>97903_97903_3_VASH1-PRKCH_VASH1_chr14_77229474_ENST00000554237_PRKCH_chr14_61952218_ENST00000332981_length(amino acids)=360AA_BP=103
MPGGKKVAGGGSSGATPTSAAATAPSGVRRLETSEGTSAQRDEEPEEEGEEDLRDGGVPFFVNRGGLPVDEATWERMWKHVAKIHPDGEK
VAQRIRGATDLPKDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKE
GICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNP
TMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQP

--------------------------------------------------------------
>97903_97903_4_VASH1-PRKCH_VASH1_chr14_77229474_ENST00000554237_PRKCH_chr14_61952218_ENST00000555082_length(transcript)=2721nt_BP=802nt
CGCGCAGATGTGAGCGTGCGAGAGTTGTGTAGGGGATTTTGTTCCCTCCGAAACTGAGACCCAGGGCGCCCAGTGGGCACCCGTGCCTTG
ACTCTGTCCTTTCTGCAGCCGCTGGTCCGAGCTGTCTGGCCTCAGTTTCCCTCCGACTTTTCTCCGCTCTGCCAGCCCTCACTGCTGCCC
GTCATTGTTCTCGCAGTTAGATGGGGGTGCTTTGTGACGGCTGCCAAGTTGGGGTGTGTTCTCTTTATTCCGTTTTTCAAACAGAACAAG
GCCTCCAAGGCTGACCCCAGACAACCCACCCCCTCGGACCCTAATTCACCTTATTGCACTGATTTTTTTTATCAAGTCGTATTTTATTGT
ACAGGAGCCACGCCCTGATTTCTTAAAGGCGCCTTGCACTCTGGCCATGTGTTATCTCTGCAGCCGGTGTGTGGGAGGCCTCTTGTGAGC
CAGTTGTTTTCCCGCCTCCACCACCCCCCTCGAAGATTTAGGGATGCCAGGGGGGAAGAAGGTGGCTGGGGGTGGCAGCAGCGGTGCCAC
TCCAACGTCCGCTGCGGCCACCGCCCCCTCTGGGGTCAGGCGTTTGGAGACCAGCGAAGGAACCTCAGCCCAGAGAGATGAGGAGCCAGA
AGAGGAAGGGGAAGAGGACCTGCGAGACGGAGGCGTCCCCTTCTTTGTCAACCGGGGTGGGCTACCTGTGGATGAGGCCACCTGGGAAAG
GATGTGGAAACACGTGGCCAAGATCCACCCCGATGGAGAGAAGGTGGCGCAACGGATCCGTGGGGCCACAGACCTGCCCAAGGATCGTCT
GTTTTTTGTGATGGAGTTTGTGAATGGGGGTGACTTGATGTTCCACATTCAGAAGTCTCGTCGTTTTGATGAAGCACGAGCTCGCTTCTA
TGCTGCAGAAATCATTTCGGCTCTCATGTTCCTCCATGATAAAGGAATCATCTATAGAGATCTGAAACTGGACAATGTCCTGTTGGACCA
CGAGGGTCACTGTAAACTGGCAGACTTCGGAATGTGCAAGGAGGGGATTTGCAATGGTGTCACCACGGCCACATTCTGTGGCACGCCAGA
CTATATCGCTCCAGAGATCCTCCAGGAAATGCTGTACGGGCCTGCAGTAGACTGGTGGGCAATGGGCGTGTTGCTCTATGAGATGCTCTG
TGGTCACGCGCCTTTTGAGGCAGAGAACGAAGATGACCTCTTTGAGGCCATACTGAATGATGAGGTGGTCTACCCTACCTGGCTCCATGA
AGATGCCACAGGGATCCTAAAATCTTTCATGACCAAGAACCCCACCATGCGCTTGGGCAGCCTGACTCAGGGAGGCGAGCACGCCATCTT
GAGACATCCTTTTTTTAAGGAAATCGACTGGGCCCAGCTGAACCATCGCCAAATAGAACCGCCTTTCAGACCCAGAATCAAATCCCGAGA
AGATGTCAGTAATTTTGACCCTGACTTCATAAAGGAAGAGCCAGTTTTAACTCCAATTGATGAGGGACATCTTCCAATGATTAACCAGGA
TGAGTTTAGAAACTTTTCCTATGTGTCTCCAGAATTGCAACCATAGCCTTATGGGGAGTGAGAGAGAGGGCACGAGAACCCAAAGGGAAT
AGAGATTCTCCAGGAATTTCCTCTATGGGACCTTCCCAGCATCAGCCTTAGAACAAGAACCTTACCTTCAAGGAGCAAGTGAAGAACTCT
GTGAAGGATGGAACTTTCAGATATCAACTATTTAGAGTCCAGAGGGAGCCATGGCACTAGAAATAGTTGATAATGAAATGAGATTTTATG
AAGTATACCGCTCCACCTATGAGCGTCTGTCTCTGTGGGCTTGGGATGTTAACAGGAGCCAAAAGGAGGGAAAGTGTGAAGAATAAAGTA
GATCTGAGAAATTCTGAGCCAATCAGGCTTCTTAATTCAAGAGACAAACCAAGACGTTCTGTCAACTGTGCTGTGCTCTTCTTTAAGCCA
ATGAACCCCAATTCCTGGCAGTCTACAAGAAGTCTCTTAATGCTAATGAAGAATTTAAAGGTCTTTTTAAGGAAATGAAGGGCTTTCCAA
ATAGAATGATTTACTCTGAAGAAACAAACAATGGTATCTCTGAAACTCACAACCTAAAGCCCAATCTTGAAAATATGTTGTGCACCAAGA
CGACTGCTTCAGCTTCTTCTCTTATCCTTACTTTCTTTAATAGATATTTATTAAACTGTCCAGTGAAAAGGTGCCACAATGCCCAGTATT
GTAAACAACAGGTTTGCATTCATGAAGCTTTCATTCATTCTGGAGTCTACTAATTTACCTGAATGGTGTTTGCATTCTGTGAAATGCCTC
TCCACGTTGCATATGTCACACTTTTGTCTGCACATAACTCTTTTTTCACAAGAAGGGTCACTGCCACAACAGCACAGTCAGCGGGTGAAT
TACAGGTGCCTGCTGCCTGCCTACCTGGGTAATCTGATCTTGTCTGTATCGCCGTGTGCTCATCACTGAAGAATTGCAGGCCACTCATGT
CAGTGACCAGATTTGTGGCTTATAAACATTAGCAGTTTATTTATGTTTTAAGATGCAAAGATGTGTGTTTGATATTCACTTTAATAATTA
GAAATGGATCTTGTAAACAGGGCATATATCAAAGATGACCTTATAATATGTACCCGAATATACAGTTCAAGAATTTTGTCTGACTGGAAA

>97903_97903_4_VASH1-PRKCH_VASH1_chr14_77229474_ENST00000554237_PRKCH_chr14_61952218_ENST00000555082_length(amino acids)=360AA_BP=103
MPGGKKVAGGGSSGATPTSAAATAPSGVRRLETSEGTSAQRDEEPEEEGEEDLRDGGVPFFVNRGGLPVDEATWERMWKHVAKIHPDGEK
VAQRIRGATDLPKDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKE
GICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNP
TMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for VASH1-PRKCH

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for VASH1-PRKCH

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for VASH1-PRKCH

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source