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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:VAV1-EXOC3 (FusionGDB2 ID:97929)

Fusion Gene Summary for VAV1-EXOC3

Fusion gene summary

Fusion gene information	Fusion gene name: VAV1-EXOC3
	Fusion gene ID: 97929
		Hgene	Tgene
	Gene symbol	VAV1	EXOC3
	Gene ID	7409	11336
	Gene name	vav guanine nucleotide exchange factor 1	exocyst complex component 3
	Synonyms	VAV	SEC6\|SEC6L1\|Sec6p
	Cytomap	19p13.3	5p15.33
	Type of gene	protein-coding	protein-coding
	Description	proto-oncogene vavvav 1 guanine nucleotide exchange factorvav 1 oncogene	exocyst complex component 3SEC6-like 1Sec 6 homologexocyst complex component Sec6
	Modification date	20200313	20200313
	UniProtAcc	.	O60645
	Ensembl transtripts involved in fusion gene	ENST00000304076, ENST00000539284, ENST00000596764, ENST00000599806, ENST00000602142,	ENST00000315013, ENST00000510441, ENST00000512944,
Fusion gene scores	* DoF score	3 X 3 X 3=27	6 X 7 X 5=210
	# samples	3	7
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: VAV1 [Title/Abstract] AND EXOC3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	VAV1(6828498)-EXOC3(465225), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across VAV1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EXOC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-61-2016	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+

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Fusion Gene ORF analysis for VAV1-EXOC3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000304076	ENST00000315013	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
5CDS-intron	ENST00000304076	ENST00000510441	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
5CDS-intron	ENST00000539284	ENST00000315013	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
5CDS-intron	ENST00000539284	ENST00000510441	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
5CDS-intron	ENST00000596764	ENST00000315013	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
5CDS-intron	ENST00000596764	ENST00000510441	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
5CDS-intron	ENST00000599806	ENST00000315013	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
5CDS-intron	ENST00000599806	ENST00000510441	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
5CDS-intron	ENST00000602142	ENST00000315013	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
5CDS-intron	ENST00000602142	ENST00000510441	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
In-frame	ENST00000304076	ENST00000512944	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
In-frame	ENST00000539284	ENST00000512944	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
In-frame	ENST00000596764	ENST00000512944	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
In-frame	ENST00000599806	ENST00000512944	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+
In-frame	ENST00000602142	ENST00000512944	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000304076

VAV1

chr19

6828498

ENST00000512944

EXOC3

chr5

465225

2046

1186

1647

530

ENST00000602142

VAV1

chr19

6828498

ENST00000512944

EXOC3

chr5

465225

2034

1174

1635

530

ENST00000596764

VAV1

chr19

6828498

ENST00000512944

EXOC3

chr5

465225

1936

1076

1537

498

ENST00000539284

VAV1

chr19

6828498

ENST00000512944

EXOC3

chr5

465225

1706

846

1307

429

ENST00000599806

VAV1

chr19

6828498

ENST00000512944

EXOC3

chr5

465225

1872

1012

1473

462

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000304076	ENST00000512944	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+	0.005180179	0.9948198
ENST00000602142	ENST00000512944	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+	0.005129177	0.9948709
ENST00000596764	ENST00000512944	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+	0.005424437	0.9945755
ENST00000539284	ENST00000512944	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+	0.005957092	0.99404293
ENST00000599806	ENST00000512944	VAV1	chr19	6828498	+	EXOC3	chr5	465225	+	0.006015251	0.99398476

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Fusion Genomic Features for VAV1-EXOC3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
VAV1	chr19	6828498	+	EXOC3	chr5	465225	+	0.000121717	0.9998783
VAV1	chr19	6828498	+	EXOC3	chr5	465225	+	0.000121717	0.9998783

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VAV1-EXOC3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:6828498/chr5:465225)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	EXOC3 O60645
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000596764

33_99

332

814.0

Compositional bias

Note=Leu-rich

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000602142

33_99

364

846.0

Compositional bias

Note=Leu-rich

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000596764

1_119

332

814.0

Domain

Calponin-homology (CH)

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000602142

1_119

364

846.0

Domain

Calponin-homology (CH)

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000596764

194_373

332

814.0

Domain

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000596764

402_504

332

814.0

Domain

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000596764

592_660

332

814.0

Domain

SH3 1

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000596764

671_765

332

814.0

Domain

SH2

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000596764

782_842

332

814.0

Domain

SH3 2

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000602142

194_373

364

846.0

Domain

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000602142

402_504

364

846.0

Domain

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000602142

592_660

364

846.0

Domain

SH3 1

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000602142

671_765

364

846.0

Domain

SH2

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000602142

782_842

364

846.0

Domain

SH3 2

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000596764

515_564

332

814.0

Zinc finger

Phorbol-ester/DAG-type

Hgene

VAV1

chr19:6828498

chr5:465225

ENST00000602142

515_564

364

846.0

Zinc finger

Phorbol-ester/DAG-type

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Fusion Gene Sequence for VAV1-EXOC3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>97929_97929_1_VAV1-EXOC3_VAV1_chr19_6828498_ENST00000304076_EXOC3_chr5_465225_ENST00000512944_length(transcript)=2046nt_BP=1186nt
AGCTGTCGCTCCACAGGCGAGCAGGGCAGGCGTGCGGGCGGGTGGGTGGTGGAGGCTGCGAGGGTGCACGGCCGGCCCTGGGCAGGCGGT
AGCCATGGAGCTGTGGCGCCAATGCACCCACTGGCTCATCCAGTGCCGGGTGCTGCCGCCCAGCCACCGCGTGACCTGGGATGGGGCTCA
GGTGTGTGAACTGGCCCAGGCCCTCCGGGATGGTGTCCTTCTGTGTCAGCTGCTTAACAACCTGCTACCCCATGCCATCAACCTGCGTGA
GGTCAACCTGCGCCCCCAGATGTCCCAGTTCCTGTGCCTTAAGAACATTAGAACCTTCCTGTCCACCTGCTGTGAGAAGTTCGGCCTCAA
GCGGAGCGAGCTCTTCGAAGCCTTTGACCTCTTCGATGTGCAGGATTTTGGCAAGGTCATCTACACCCTGTCTGCTCTGTCCTGGACCCC
GATCGCCCAGAACAGGGGGATCATGCCCTTCCCCACCGAGGAGGAGAGTGTAGGTGATGAAGACATCTACAGTGGCCTGTCCGACCAGAT
CGACGACACGGTGGAGGAGGATGAGGACCTGTATGACTGCGTGGAGAATGAGGAGGCGGAAGGCGACGAGATCTATGAGGACCTCATGCG
CTCGGAGCCCGTGTCCATGCCGCCCAAGATGACAGAGTATGACAAGCGCTGCTGCTGCCTGCGGGAGATCCAGCAGACGGAGGAGAAGTA
CACTGACACGCTGGGCTCCATCCAGCAGCATTTCTTGAAGCCCCTGCAACGGTTCCTGAAACCTCAAGACATTGAGATCATCTTTATCAA
CATTGAGGACCTGCTTCGTGTTCATACTCACTTCCTAAAGGAGATGAAGGAAGCCCTGGGCACCCCTGGCGCAGCCAATCTCTACCAGGT
CTTCATCAAATACAAGGAGAGGTTCCTCGTCTATGGCCGCTACTGCAGCCAGGTGGAGTCAGCCAGCAAACACCTGGACCGTGTGGCCGC
AGCCCGGGAGGACGTGCAGATGAAGCTGGAGGAATGTTCTCAGAGAGCCAACAACGGGAGGTTCACCCTGCGGGACCTGCTGATGGTGCC
TATGCAGCGAGTTCTCAAATATCACCTCCTTCTCCAGGAGCTGGTGAAACACACGCAGGAGGCGATGGAGAAGGAGAACCTGCGGCTGGC
CCTGGATGCCATGAGGAGGATGACGGCCGAGGCGCACCGGCGCGTGGTGGTGGAGTACCTGCGGGCGGTCATGCAGAAGCGCATTTCCTT
CCGGAGCCCGGAGGAGCGCAAGGAGGGTGCCGAGAAGATGGTTAGGGAGGCAGAGCAGCTGCGCTTCCTGTTCCGGAAGCTGGCGTCCGG
TTTCGGGGAAGACGTGGACGGATACTGCGACACCATCGTGGCTGTGGCCGAAGTGATCAAGCTGACAGACCCTTCTCTGCTCTACCTGGA
GGTCTCCACTCTGGTCAGCAAGTATCCAGACATCAGGGATGACCACATCGGTGCGCTGCTGGCTGTGCGTGGGGACGCCAGCCGTGACAT
GAAGCAGACCATCATGGAGACCCTGGAGCAGGGCCCAGCACAGGCCAGCCCCAGCTACGTGCCCCTCTTCAAGGACATTGTGGTGCCCAG
CCTGAACGTGGCCAAGCTGCTCAAGTAGCCTCCGCCGGCCTGCCCTGCTCGCCCCTCCACAGCCTCGGTCCCTGCCTTTAGAAACGCGGG
ACAGCTGATTGCTCTCCTTGGCCACACGTGCTCCTTTTAGCTGCACGGCCTGTCTTTAGGTGCCAGTGTGATGCACCGGGTGTGCGTCGA
GTGAGCGTCCCGAGGCCACGTGCGGAGGCCCCTCACTGTGCTGTCAAAGGCCTGTGGGTGCAGGGCTCTGCCGCACAGCCTCTCTTGGGT
GCTTGTTTGTTGCAGTGGTTGAAAGTGTGTGGGGCACAGAGGACGTGCACCTCCCTGCCCTCCTCCTCCCTGGGCCTTCACCGCACCCCA

>97929_97929_1_VAV1-EXOC3_VAV1_chr19_6828498_ENST00000304076_EXOC3_chr5_465225_ENST00000512944_length(amino acids)=530AA_BP=377
MRGCTAGPGQAVAMELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRT
FLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEE
AEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEA
LGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT
QEAMEKENLRLALDAMRRMTAEAHRRVVVEYLRAVMQKRISFRSPEERKEGAEKMVREAEQLRFLFRKLASGFGEDVDGYCDTIVAVAEV

--------------------------------------------------------------
>97929_97929_2_VAV1-EXOC3_VAV1_chr19_6828498_ENST00000539284_EXOC3_chr5_465225_ENST00000512944_length(transcript)=1706nt_BP=846nt
CTACCCCATGCCATCAACCTGCGTGAGGTCAACCTGCGCCCCCAGATGTCCCAGTTCCTGTGCCTTAAGAACATTAGAACCTTCCTGTCC
ACCTGCTGTGAGAAGTTCGGCCTCAAGCGGAGCGAGCTCTTCGAAGCCTTTGACCTCTTCGATGTGCAGGATTTTGGCAAGGTCATCTAC
ACCCTGTCTGCTCTGTCCTGGACCCCGATCGCCCAGAACAGGGGGATCATGCCCTTCCCCACCGAGGAGGAGAGTGTAGGTGATGAAGAC
ATCTACAGTGGCCTGTCCGACCAGATCGACGACACGGTGGAGGAGGATGAGGACCTGTATGACTGCGTGGAGAATGAGGAGGCGGAAGGC
GACGAGATCTATGAGGACCTCATGCGCTCGGAGCCCGTGTCCATGCCGCATTTCTTGAAGCCCCTGCAACGGTTCCTGAAACCTCAAGAC
ATTGAGATCATCTTTATCAACATTGAGGACCTGCTTCGTGTTCATACTCACTTCCTAAAGGAGATGAAGGAAGCCCTGGGCACCCCTGGC
GCAGCCAATCTCTACCAGGTCTTCATCAAATACAAGGAGAGGTTCCTCGTCTATGGCCGCTACTGCAGCCAGGTGGAGTCAGCCAGCAAA
CACCTGGACCGTGTGGCCGCAGCCCGGGAGGACGTGCAGATGAAGCTGGAGGAATGTTCTCAGAGAGCCAACAACGGGAGGTTCACCCTG
CGGGACCTGCTGATGGTGCCTATGCAGCGAGTTCTCAAATATCACCTCCTTCTCCAGGAGCTGGTGAAACACACGCAGGAGGCGATGGAG
AAGGAGAACCTGCGGCTGGCCCTGGATGCCATGAGGAGGATGACGGCCGAGGCGCACCGGCGCGTGGTGGTGGAGTACCTGCGGGCGGTC
ATGCAGAAGCGCATTTCCTTCCGGAGCCCGGAGGAGCGCAAGGAGGGTGCCGAGAAGATGGTTAGGGAGGCAGAGCAGCTGCGCTTCCTG
TTCCGGAAGCTGGCGTCCGGTTTCGGGGAAGACGTGGACGGATACTGCGACACCATCGTGGCTGTGGCCGAAGTGATCAAGCTGACAGAC
CCTTCTCTGCTCTACCTGGAGGTCTCCACTCTGGTCAGCAAGTATCCAGACATCAGGGATGACCACATCGGTGCGCTGCTGGCTGTGCGT
GGGGACGCCAGCCGTGACATGAAGCAGACCATCATGGAGACCCTGGAGCAGGGCCCAGCACAGGCCAGCCCCAGCTACGTGCCCCTCTTC
AAGGACATTGTGGTGCCCAGCCTGAACGTGGCCAAGCTGCTCAAGTAGCCTCCGCCGGCCTGCCCTGCTCGCCCCTCCACAGCCTCGGTC
CCTGCCTTTAGAAACGCGGGACAGCTGATTGCTCTCCTTGGCCACACGTGCTCCTTTTAGCTGCACGGCCTGTCTTTAGGTGCCAGTGTG
ATGCACCGGGTGTGCGTCGAGTGAGCGTCCCGAGGCCACGTGCGGAGGCCCCTCACTGTGCTGTCAAAGGCCTGTGGGTGCAGGGCTCTG
CCGCACAGCCTCTCTTGGGTGCTTGTTTGTTGCAGTGGTTGAAAGTGTGTGGGGCACAGAGGACGTGCACCTCCCTGCCCTCCTCCTCCC

>97929_97929_2_VAV1-EXOC3_VAV1_chr19_6828498_ENST00000539284_EXOC3_chr5_465225_ENST00000512944_length(amino acids)=429AA_BP=276
MREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLS
DQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQ
VFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRL
ALDAMRRMTAEAHRRVVVEYLRAVMQKRISFRSPEERKEGAEKMVREAEQLRFLFRKLASGFGEDVDGYCDTIVAVAEVIKLTDPSLLYL

--------------------------------------------------------------
>97929_97929_3_VAV1-EXOC3_VAV1_chr19_6828498_ENST00000596764_EXOC3_chr5_465225_ENST00000512944_length(transcript)=1936nt_BP=1076nt
AGGCGAGCAGGGCAGGCGTGCGGGCGGGTGGGTGGTGGAGGCTGCGAGGGTGCACGGCCGGCCCTGGGCAGGCGGTAGCCATGGAGCTGT
GGCGCCAATGCACCCACTGGCTCATCCAGTGCCGGGTGCTGCCGCCCAGCCACCGCGTGACCTGGGATGGGGCTCAGGTGTGTGAACTGG
CCCAGGCCCTCCGGGATGGTGTCCTTCTGTGTCAGCTGCTTAACAACCTGCTACCCCATGCCATCAACCTGCGTGAGGTCAACCTGCGCC
CCCAGATGTCCCAGTTCCTGTGCCTTAAGAACATTAGAACCTTCCTGTCCACCTGCTGTGAGAAGTTCGGCCTCAAGCGGAGCGAGCTCT
TCGAAGCCTTTGACCTCTTCGATGTGCAGGATTTTGGCAAGGTCATCTACACCCTGTCTGCTCTGTCCTGGACCCCGATCGCCCAGAACA
GGGGGATCATGCCCTTCCCCACCGAGGAGGAGAGTGTAGGTGATGAAGACATCTACAGTGGCCTGTCCGACCAGATCGACGACACGGTGG
AGGAGGATGAGGACCTGTATGACTGCGTGGAGAATGAGGAGGCGGAAGGCGACGAGATCTATGAGGACCTCATGCGCTCGGAGCCCGTGT
CCATGCCGCATTTCTTGAAGCCCCTGCAACGGTTCCTGAAACCTCAAGACATTGAGATCATCTTTATCAACATTGAGGACCTGCTTCGTG
TTCATACTCACTTCCTAAAGGAGATGAAGGAAGCCCTGGGCACCCCTGGCGCAGCCAATCTCTACCAGGTCTTCATCAAATACAAGGAGA
GGTTCCTCGTCTATGGCCGCTACTGCAGCCAGGTGGAGTCAGCCAGCAAACACCTGGACCGTGTGGCCGCAGCCCGGGAGGACGTGCAGA
TGAAGCTGGAGGAATGTTCTCAGAGAGCCAACAACGGGAGGTTCACCCTGCGGGACCTGCTGATGGTGCCTATGCAGCGAGTTCTCAAAT
ATCACCTCCTTCTCCAGGAGCTGGTGAAACACACGCAGGAGGCGATGGAGAAGGAGAACCTGCGGCTGGCCCTGGATGCCATGAGGAGGA
TGACGGCCGAGGCGCACCGGCGCGTGGTGGTGGAGTACCTGCGGGCGGTCATGCAGAAGCGCATTTCCTTCCGGAGCCCGGAGGAGCGCA
AGGAGGGTGCCGAGAAGATGGTTAGGGAGGCAGAGCAGCTGCGCTTCCTGTTCCGGAAGCTGGCGTCCGGTTTCGGGGAAGACGTGGACG
GATACTGCGACACCATCGTGGCTGTGGCCGAAGTGATCAAGCTGACAGACCCTTCTCTGCTCTACCTGGAGGTCTCCACTCTGGTCAGCA
AGTATCCAGACATCAGGGATGACCACATCGGTGCGCTGCTGGCTGTGCGTGGGGACGCCAGCCGTGACATGAAGCAGACCATCATGGAGA
CCCTGGAGCAGGGCCCAGCACAGGCCAGCCCCAGCTACGTGCCCCTCTTCAAGGACATTGTGGTGCCCAGCCTGAACGTGGCCAAGCTGC
TCAAGTAGCCTCCGCCGGCCTGCCCTGCTCGCCCCTCCACAGCCTCGGTCCCTGCCTTTAGAAACGCGGGACAGCTGATTGCTCTCCTTG
GCCACACGTGCTCCTTTTAGCTGCACGGCCTGTCTTTAGGTGCCAGTGTGATGCACCGGGTGTGCGTCGAGTGAGCGTCCCGAGGCCACG
TGCGGAGGCCCCTCACTGTGCTGTCAAAGGCCTGTGGGTGCAGGGCTCTGCCGCACAGCCTCTCTTGGGTGCTTGTTTGTTGCAGTGGTT
GAAAGTGTGTGGGGCACAGAGGACGTGCACCTCCCTGCCCTCCTCCTCCCTGGGCCTTCACCGCACCCCATCTGCTTAAGTGCTCGGAAC

>97929_97929_3_VAV1-EXOC3_VAV1_chr19_6828498_ENST00000596764_EXOC3_chr5_465225_ENST00000512944_length(amino acids)=498AA_BP=345
MRGCTAGPGQAVAMELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRT
FLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEE
AEGDEIYEDLMRSEPVSMPHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVES
ASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRRMTAEAHRRVVVEYL
RAVMQKRISFRSPEERKEGAEKMVREAEQLRFLFRKLASGFGEDVDGYCDTIVAVAEVIKLTDPSLLYLEVSTLVSKYPDIRDDHIGALL

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>97929_97929_4_VAV1-EXOC3_VAV1_chr19_6828498_ENST00000599806_EXOC3_chr5_465225_ENST00000512944_length(transcript)=1872nt_BP=1012nt
GTGGTGCACGCCTATAGTCTCAGCTACTCAGGAAGTTGAGGCAGGAGGATCGCTTGAGCCCAGGAGTTTGATGCTGCAGTGAGCTATGAT
TGTGCTACCACTGTACTCCAGACTGGACAAAAGATTCCTGTGCCTTAAGAACATTAGAACCTTCCTGTCCACCTGCTGTGAGAAGTTCGG
CCTCAAGCGGAGCGAGCTCTTCGAAGCCTTTGACCTCTTCGATGTGCAGGATTTTGGCAAGGTCATCTACACCCTGTCTGCTCTGTCCTG
GACCCCGATCGCCCAGAACAGGGGGATCATGCCCTTCCCCACCGAGGAGGAGAGTGTAGGTGATGAAGACATCTACAGTGGCCTGTCCGA
CCAGATCGACGACACGGTGGAGGAGGATGAGGACCTGTATGACTGCGTGGAGAATGAGGAGGCGGAAGGCGACGAGATCTATGAGGACCT
CATGCGCTCGGAGCCCGTGTCCATGCCGCCCAAGATGACAGAGTATGACAAGCGCTGCTGCTGCCTGCGGGAGATCCAGCAGACGGAGGA
GAAGTACACTGACACGCTGGGCTCCATCCAGCAGCATTTCTTGAAGCCCCTGCAACGGTTCCTGAAACCTCAAGACATTGAGATCATCTT
TATCAACATTGAGGACCTGCTTCGTGTTCATACTCACTTCCTAAAGGAGATGAAGGAAGCCCTGGGCACCCCTGGCGCAGCCAATCTCTA
CCAGGTCTTCATCAAATACAAGGAGAGGTTCCTCGTCTATGGCCGCTACTGCAGCCAGGTGGAGTCAGCCAGCAAACACCTGGACCGTGT
GGCCGCAGCCCGGGAGGACGTGCAGATGAAGCTGGAGGAATGTTCTCAGAGAGCCAACAACGGGAGGTTCACCCTGCGGGACCTGCTGAT
GGTGCCTATGCAGCGAGTTCTCAAATATCACCTCCTTCTCCAGGAGCTGGTGAAACACACGCAGGAGGCGATGGAGAAGGAGAACCTGCG
GCTGGCCCTGGATGCCATGAGGAGGATGACGGCCGAGGCGCACCGGCGCGTGGTGGTGGAGTACCTGCGGGCGGTCATGCAGAAGCGCAT
TTCCTTCCGGAGCCCGGAGGAGCGCAAGGAGGGTGCCGAGAAGATGGTTAGGGAGGCAGAGCAGCTGCGCTTCCTGTTCCGGAAGCTGGC
GTCCGGTTTCGGGGAAGACGTGGACGGATACTGCGACACCATCGTGGCTGTGGCCGAAGTGATCAAGCTGACAGACCCTTCTCTGCTCTA
CCTGGAGGTCTCCACTCTGGTCAGCAAGTATCCAGACATCAGGGATGACCACATCGGTGCGCTGCTGGCTGTGCGTGGGGACGCCAGCCG
TGACATGAAGCAGACCATCATGGAGACCCTGGAGCAGGGCCCAGCACAGGCCAGCCCCAGCTACGTGCCCCTCTTCAAGGACATTGTGGT
GCCCAGCCTGAACGTGGCCAAGCTGCTCAAGTAGCCTCCGCCGGCCTGCCCTGCTCGCCCCTCCACAGCCTCGGTCCCTGCCTTTAGAAA
CGCGGGACAGCTGATTGCTCTCCTTGGCCACACGTGCTCCTTTTAGCTGCACGGCCTGTCTTTAGGTGCCAGTGTGATGCACCGGGTGTG
CGTCGAGTGAGCGTCCCGAGGCCACGTGCGGAGGCCCCTCACTGTGCTGTCAAAGGCCTGTGGGTGCAGGGCTCTGCCGCACAGCCTCTC
TTGGGTGCTTGTTTGTTGCAGTGGTTGAAAGTGTGTGGGGCACAGAGGACGTGCACCTCCCTGCCCTCCTCCTCCCTGGGCCTTCACCGC

>97929_97929_4_VAV1-EXOC3_VAV1_chr19_6828498_ENST00000599806_EXOC3_chr5_465225_ENST00000512944_length(amino acids)=462AA_BP=309
MIVLPLYSRLDKRFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGL
SDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEI
IFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDL
LMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRRMTAEAHRRVVVEYLRAVMQKRISFRSPEERKEGAEKMVREAEQLRFLFRK
LASGFGEDVDGYCDTIVAVAEVIKLTDPSLLYLEVSTLVSKYPDIRDDHIGALLAVRGDASRDMKQTIMETLEQGPAQASPSYVPLFKDI

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>97929_97929_5_VAV1-EXOC3_VAV1_chr19_6828498_ENST00000602142_EXOC3_chr5_465225_ENST00000512944_length(transcript)=2034nt_BP=1174nt
ACAGGCGAGCAGGGCAGGCGTGCGGGCGGGTGGGTGGTGGAGGCTGCGAGGGTGCACGGCCGGCCCTGGGCAGGCGGTAGCCATGGAGCT
GTGGCGCCAATGCACCCACTGGCTCATCCAGTGCCGGGTGCTGCCGCCCAGCCACCGCGTGACCTGGGATGGGGCTCAGGTGTGTGAACT
GGCCCAGGCCCTCCGGGATGGTGTCCTTCTGTGTCAGCTGCTTAACAACCTGCTACCCCATGCCATCAACCTGCGTGAGGTCAACCTGCG
CCCCCAGATGTCCCAGTTCCTGTGCCTTAAGAACATTAGAACCTTCCTGTCCACCTGCTGTGAGAAGTTCGGCCTCAAGCGGAGCGAGCT
CTTCGAAGCCTTTGACCTCTTCGATGTGCAGGATTTTGGCAAGGTCATCTACACCCTGTCTGCTCTGTCCTGGACCCCGATCGCCCAGAA
CAGGGGGATCATGCCCTTCCCCACCGAGGAGGAGAGTGTAGGTGATGAAGACATCTACAGTGGCCTGTCCGACCAGATCGACGACACGGT
GGAGGAGGATGAGGACCTGTATGACTGCGTGGAGAATGAGGAGGCGGAAGGCGACGAGATCTATGAGGACCTCATGCGCTCGGAGCCCGT
GTCCATGCCGCCCAAGATGACAGAGTATGACAAGCGCTGCTGCTGCCTGCGGGAGATCCAGCAGACGGAGGAGAAGTACACTGACACGCT
GGGCTCCATCCAGCAGCATTTCTTGAAGCCCCTGCAACGGTTCCTGAAACCTCAAGACATTGAGATCATCTTTATCAACATTGAGGACCT
GCTTCGTGTTCATACTCACTTCCTAAAGGAGATGAAGGAAGCCCTGGGCACCCCTGGCGCAGCCAATCTCTACCAGGTCTTCATCAAATA
CAAGGAGAGGTTCCTCGTCTATGGCCGCTACTGCAGCCAGGTGGAGTCAGCCAGCAAACACCTGGACCGTGTGGCCGCAGCCCGGGAGGA
CGTGCAGATGAAGCTGGAGGAATGTTCTCAGAGAGCCAACAACGGGAGGTTCACCCTGCGGGACCTGCTGATGGTGCCTATGCAGCGAGT
TCTCAAATATCACCTCCTTCTCCAGGAGCTGGTGAAACACACGCAGGAGGCGATGGAGAAGGAGAACCTGCGGCTGGCCCTGGATGCCAT
GAGGAGGATGACGGCCGAGGCGCACCGGCGCGTGGTGGTGGAGTACCTGCGGGCGGTCATGCAGAAGCGCATTTCCTTCCGGAGCCCGGA
GGAGCGCAAGGAGGGTGCCGAGAAGATGGTTAGGGAGGCAGAGCAGCTGCGCTTCCTGTTCCGGAAGCTGGCGTCCGGTTTCGGGGAAGA
CGTGGACGGATACTGCGACACCATCGTGGCTGTGGCCGAAGTGATCAAGCTGACAGACCCTTCTCTGCTCTACCTGGAGGTCTCCACTCT
GGTCAGCAAGTATCCAGACATCAGGGATGACCACATCGGTGCGCTGCTGGCTGTGCGTGGGGACGCCAGCCGTGACATGAAGCAGACCAT
CATGGAGACCCTGGAGCAGGGCCCAGCACAGGCCAGCCCCAGCTACGTGCCCCTCTTCAAGGACATTGTGGTGCCCAGCCTGAACGTGGC
CAAGCTGCTCAAGTAGCCTCCGCCGGCCTGCCCTGCTCGCCCCTCCACAGCCTCGGTCCCTGCCTTTAGAAACGCGGGACAGCTGATTGC
TCTCCTTGGCCACACGTGCTCCTTTTAGCTGCACGGCCTGTCTTTAGGTGCCAGTGTGATGCACCGGGTGTGCGTCGAGTGAGCGTCCCG
AGGCCACGTGCGGAGGCCCCTCACTGTGCTGTCAAAGGCCTGTGGGTGCAGGGCTCTGCCGCACAGCCTCTCTTGGGTGCTTGTTTGTTG
CAGTGGTTGAAAGTGTGTGGGGCACAGAGGACGTGCACCTCCCTGCCCTCCTCCTCCCTGGGCCTTCACCGCACCCCATCTGCTTAAGTG

>97929_97929_5_VAV1-EXOC3_VAV1_chr19_6828498_ENST00000602142_EXOC3_chr5_465225_ENST00000512944_length(amino acids)=530AA_BP=377
MRGCTAGPGQAVAMELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRT
FLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEE
AEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEA
LGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT
QEAMEKENLRLALDAMRRMTAEAHRRVVVEYLRAVMQKRISFRSPEERKEGAEKMVREAEQLRFLFRKLASGFGEDVDGYCDTIVAVAEV

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Fusion Gene PPI Analysis for VAV1-EXOC3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for VAV1-EXOC3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for VAV1-EXOC3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source