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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VEGFA-URI1 (FusionGDB2 ID:98040)

Fusion Gene Summary for VEGFA-URI1

check button Fusion gene summary
Fusion gene informationFusion gene name: VEGFA-URI1
Fusion gene ID: 98040
HgeneTgene
Gene symbol

VEGFA

URI1

Gene ID

7422

8725

Gene namevascular endothelial growth factor AURI1 prefoldin like chaperone
SynonymsMVCD1|VEGF|VPFC19orf2|NNX3|PPP1R19|RMP|URI
Cytomap

6p21.1

19q12

Type of geneprotein-codingprotein-coding
Descriptionvascular endothelial growth factor Avascular endothelial growth factor A121vascular endothelial growth factor A165vascular permeability factorunconventional prefoldin RPB5 interactor 1RNA polymerase II subunit 5-mediating proteinRPB5-mediating proteinprotein phosphatase 1, regulatory subunit 19
Modification date2020032920200313
UniProtAcc.

O94763

Ensembl transtripts involved in fusion geneENST00000230480, ENST00000372055, 
ENST00000372067, ENST00000413642, 
ENST00000417285, ENST00000425836, 
ENST00000482630, ENST00000518689, 
ENST00000518824, ENST00000520948, 
ENST00000523125, ENST00000523873, 
ENST00000523950, ENST00000324450, 
ENST00000372064, ENST00000372077, 
ENST00000457104, 		ENST00000392271, 
ENST00000542441, ENST00000312051, 
ENST00000360605, ENST00000574176, 
Fusion gene scores* DoF score13 X 10 X 8=104016 X 13 X 8=1664
# samples 1418
** MAII scorelog2(14/1040*10)=-2.89308479608349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1664*10)=-3.20858662181142
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VEGFA [Title/Abstract] AND URI1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVEGFA(43749719)-URI1(30433333), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneVEGFA

GO:0000122

negative regulation of transcription by RNA polymerase II

18093989

HgeneVEGFA

GO:0001525

angiogenesis

11427521|21771332

HgeneVEGFA

GO:0001666

response to hypoxia

16490744

HgeneVEGFA

GO:0001934

positive regulation of protein phosphorylation

18386220|19033661

HgeneVEGFA

GO:0001938

positive regulation of endothelial cell proliferation

9202027|10022831|12714610|16489009|18386220|18577655|20497126

HgeneVEGFA

GO:0002042

cell migration involved in sprouting angiogenesis

18059339|20660291

HgeneVEGFA

GO:0002092

positive regulation of receptor internalization

20660291

HgeneVEGFA

GO:0008284

positive regulation of cell proliferation

7929439

HgeneVEGFA

GO:0008360

regulation of cell shape

7929439|10527820

HgeneVEGFA

GO:0010595

positive regulation of endothelial cell migration

10022831|19033661

HgeneVEGFA

GO:0010628

positive regulation of gene expression

18386220

HgeneVEGFA

GO:0010629

negative regulation of gene expression

28977001

HgeneVEGFA

GO:0010749

regulation of nitric oxide mediated signal transduction

16150726

HgeneVEGFA

GO:0030224

monocyte differentiation

21149635

HgeneVEGFA

GO:0030225

macrophage differentiation

21149635

HgeneVEGFA

GO:0030335

positive regulation of cell migration

7929439|17470632

HgeneVEGFA

GO:0030949

positive regulation of vascular endothelial growth factor receptor signaling pathway

1312256|7929439

HgeneVEGFA

GO:0031334

positive regulation of protein complex assembly

16489009|19033661

HgeneVEGFA

GO:0031954

positive regulation of protein autophosphorylation

20497126

HgeneVEGFA

GO:0032147

activation of protein kinase activity

18059339|20497126

HgeneVEGFA

GO:0032793

positive regulation of CREB transcription factor activity

20497126

HgeneVEGFA

GO:0033138

positive regulation of peptidyl-serine phosphorylation

18440775|20497126

HgeneVEGFA

GO:0035148

tube formation

19033661

HgeneVEGFA

GO:0035767

endothelial cell chemotaxis

18440775

HgeneVEGFA

GO:0035924

cellular response to vascular endothelial growth factor stimulus

18440775|20497126

HgeneVEGFA

GO:0038033

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

18440775|20497126|21245381

HgeneVEGFA

GO:0038091

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

17470632

HgeneVEGFA

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

19390056

HgeneVEGFA

GO:0043117

positive regulation of vascular permeability

26598555

HgeneVEGFA

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

18386220

HgeneVEGFA

GO:0043406

positive regulation of MAP kinase activity

18440775

HgeneVEGFA

GO:0043536

positive regulation of blood vessel endothelial cell migration

9202027|18440775|20497126

HgeneVEGFA

GO:0045766

positive regulation of angiogenesis

18440775|18577655|19033661|20497126

HgeneVEGFA

GO:0045785

positive regulation of cell adhesion

19674970

HgeneVEGFA

GO:0045944

positive regulation of transcription by RNA polymerase II

18059339

HgeneVEGFA

GO:0048010

vascular endothelial growth factor receptor signaling pathway

21245381

HgeneVEGFA

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

10022831|16489009|20048167|21245381|26598555

HgeneVEGFA

GO:0050918

positive chemotaxis

20497126

HgeneVEGFA

GO:0050927

positive regulation of positive chemotaxis

7929439|12744932

HgeneVEGFA

GO:0051272

positive regulation of cellular component movement

10527820|12744932

HgeneVEGFA

GO:0051894

positive regulation of focal adhesion assembly

16489009

HgeneVEGFA

GO:0071456

cellular response to hypoxia

10575000

HgeneVEGFA

GO:0090037

positive regulation of protein kinase C signaling

18059339

HgeneVEGFA

GO:0090050

positive regulation of cell migration involved in sprouting angiogenesis

20551324

HgeneVEGFA

GO:0097533

cellular stress response to acid chemical

26299712

HgeneVEGFA

GO:1900086

positive regulation of peptidyl-tyrosine autophosphorylation

20660291

HgeneVEGFA

GO:1900745

positive regulation of p38MAPK cascade

18386220

HgeneVEGFA

GO:1901727

positive regulation of histone deacetylase activity

20497126

HgeneVEGFA

GO:1903141

negative regulation of establishment of endothelial barrier

20048167

HgeneVEGFA

GO:1903392

negative regulation of adherens junction organization

26598555

HgeneVEGFA

GO:1903572

positive regulation of protein kinase D signaling

20497126

HgeneVEGFA

GO:1903672

positive regulation of sprouting angiogenesis

26299712

HgeneVEGFA

GO:2000048

negative regulation of cell-cell adhesion mediated by cadherin

26598555

TgeneURI1

GO:0000122

negative regulation of transcription by RNA polymerase II

12737519|15367675|21730289

TgeneURI1

GO:0001558

regulation of cell growth

21730289

TgeneURI1

GO:0071363

cellular response to growth factor stimulus

17936702

TgeneURI1

GO:0071383

cellular response to steroid hormone stimulus

21730289


check buttonFusion gene breakpoints across VEGFA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across URI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI869727VEGFAchr6

43749719

+URI1chr19

30433333

-


Top

Fusion Gene ORF analysis for VEGFA-URI1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000230480ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000230480ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000372055ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000372055ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000372067ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000372067ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000413642ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000413642ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000417285ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000417285ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000425836ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000425836ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000482630ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000482630ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000518689ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000518689ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000518824ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000518824ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000520948ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000520948ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000523125ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000523125ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000523873ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000523873ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000523950ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-5UTRENST00000523950ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000230480ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000230480ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000230480ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000372055ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000372055ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000372055ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000372067ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000372067ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000372067ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000413642ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000413642ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000413642ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000417285ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000417285ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000417285ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000425836ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000425836ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000425836ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000482630ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000482630ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000482630ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000518689ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000518689ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000518689ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000518824ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000518824ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000518824ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000520948ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000520948ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000520948ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000523125ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000523125ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000523125ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000523873ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000523873ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000523873ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000523950ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000523950ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
5CDS-intronENST00000523950ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-5UTRENST00000324450ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-5UTRENST00000324450ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-5UTRENST00000372064ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-5UTRENST00000372064ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-5UTRENST00000372077ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-5UTRENST00000372077ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-5UTRENST00000457104ENST00000392271VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-5UTRENST00000457104ENST00000542441VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-intronENST00000324450ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-intronENST00000324450ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-intronENST00000324450ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-intronENST00000372064ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-intronENST00000372064ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-intronENST00000372064ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-intronENST00000372077ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-intronENST00000372077ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-intronENST00000372077ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-intronENST00000457104ENST00000312051VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-intronENST00000457104ENST00000360605VEGFAchr6

43749719

+URI1chr19

30433333

-
intron-intronENST00000457104ENST00000574176VEGFAchr6

43749719

+URI1chr19

30433333

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for VEGFA-URI1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VEGFA-URI1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:43749719/:30433333)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.URI1

O94763

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for VEGFA-URI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for VEGFA-URI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VEGFA-URI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VEGFA-URI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource