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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VILL-ITGA9 (FusionGDB2 ID:98097)

Fusion Gene Summary for VILL-ITGA9

check button Fusion gene summary
Fusion gene informationFusion gene name: VILL-ITGA9
Fusion gene ID: 98097
HgeneTgene
Gene symbol

VILL

ITGA9

Gene ID

50853

3680

Gene namevillin likeintegrin subunit alpha 9
Synonyms-ALPHA-RLC|ITGA4L|RLC
Cytomap

3p22.2

3p22.2

Type of geneprotein-codingprotein-coding
Descriptionvillin-like proteinintegrin alpha-9integrin alpha-RLC
Modification date2020031320200313
UniProtAcc.

Q13797

Ensembl transtripts involved in fusion geneENST00000283713, ENST00000383759, 
ENST00000465644, 		ENST00000422441, 
ENST00000264741, 
Fusion gene scores* DoF score4 X 4 X 4=649 X 9 X 4=324
# samples 49
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VILL [Title/Abstract] AND ITGA9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVILL(38035463)-ITGA9(37818883), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across VILL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITGA9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-PG-A914-01AVILLchr3

38035463

+ITGA9chr3

37818883

+


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Fusion Gene ORF analysis for VILL-ITGA9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000283713ENST00000422441VILLchr3

38035463

+ITGA9chr3

37818883

+
5CDS-intronENST00000383759ENST00000422441VILLchr3

38035463

+ITGA9chr3

37818883

+
In-frameENST00000283713ENST00000264741VILLchr3

38035463

+ITGA9chr3

37818883

+
In-frameENST00000383759ENST00000264741VILLchr3

38035463

+ITGA9chr3

37818883

+
intron-3CDSENST00000465644ENST00000264741VILLchr3

38035463

+ITGA9chr3

37818883

+
intron-intronENST00000465644ENST00000422441VILLchr3

38035463

+ITGA9chr3

37818883

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000283713VILLchr338035463+ENST00000264741ITGA9chr337818883+5493401224967247
ENST00000383759VILLchr338035463+ENST00000264741ITGA9chr337818883+531322144787247

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000283713ENST00000264741VILLchr338035463+ITGA9chr337818883+0.0014563360.99854374
ENST00000383759ENST00000264741VILLchr338035463+ITGA9chr337818883+0.0013197370.9986803

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Fusion Genomic Features for VILL-ITGA9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
VILLchr338035463+ITGA9chr337818882+0.0590326970.9409673
VILLchr338035463+ITGA9chr337818882+0.0590326970.9409673

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for VILL-ITGA9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:38035463/chr3:37818883)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ITGA9

Q13797

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneITGA9chr3:38035463chr3:37818883ENST0000026474122281005_10098471036.0MotifNote=GFFKR motif
TgeneITGA9chr3:38035463chr3:37818883ENST0000026474122281003_10358471036.0Topological domainCytoplasmic
TgeneITGA9chr3:38035463chr3:37818883ENST000002647412228982_10028471036.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVILLchr3:38035463chr3:37818883ENST00000283713+320790_85645857.0DomainHP
HgeneVILLchr3:38035463chr3:37818883ENST00000383759+219790_85645857.0DomainHP
HgeneVILLchr3:38035463chr3:37818883ENST00000283713+320146_18645857.0RepeatNote=Gelsolin-like 2
HgeneVILLchr3:38035463chr3:37818883ENST00000283713+32022_7445857.0RepeatNote=Gelsolin-like 1
HgeneVILLchr3:38035463chr3:37818883ENST00000283713+320263_30745857.0RepeatNote=Gelsolin-like 3
HgeneVILLchr3:38035463chr3:37818883ENST00000283713+320401_45045857.0RepeatNote=Gelsolin-like 4
HgeneVILLchr3:38035463chr3:37818883ENST00000283713+320521_56145857.0RepeatNote=Gelsolin-like 5
HgeneVILLchr3:38035463chr3:37818883ENST00000283713+320624_66545857.0RepeatNote=Gelsolin-like 6
HgeneVILLchr3:38035463chr3:37818883ENST00000383759+219146_18645857.0RepeatNote=Gelsolin-like 2
HgeneVILLchr3:38035463chr3:37818883ENST00000383759+21922_7445857.0RepeatNote=Gelsolin-like 1
HgeneVILLchr3:38035463chr3:37818883ENST00000383759+219263_30745857.0RepeatNote=Gelsolin-like 3
HgeneVILLchr3:38035463chr3:37818883ENST00000383759+219401_45045857.0RepeatNote=Gelsolin-like 4
HgeneVILLchr3:38035463chr3:37818883ENST00000383759+219521_56145857.0RepeatNote=Gelsolin-like 5
HgeneVILLchr3:38035463chr3:37818883ENST00000383759+219624_66545857.0RepeatNote=Gelsolin-like 6
TgeneITGA9chr3:38035463chr3:37818883ENST000002647412228312_3208471036.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA9chr3:38035463chr3:37818883ENST000002647412228373_3818471036.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA9chr3:38035463chr3:37818883ENST000002647412228435_4438471036.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA9chr3:38035463chr3:37818883ENST000002647412228111_1748471036.0RepeatFG-GAP 2
TgeneITGA9chr3:38035463chr3:37818883ENST000002647412228182_2328471036.0RepeatFG-GAP 3
TgeneITGA9chr3:38035463chr3:37818883ENST000002647412228233_2898471036.0RepeatFG-GAP 4
TgeneITGA9chr3:38035463chr3:37818883ENST000002647412228290_3498471036.0RepeatFG-GAP 5
TgeneITGA9chr3:38035463chr3:37818883ENST000002647412228351_4088471036.0RepeatFG-GAP 6
TgeneITGA9chr3:38035463chr3:37818883ENST00000264741222835_968471036.0RepeatFG-GAP 1
TgeneITGA9chr3:38035463chr3:37818883ENST000002647412228411_4748471036.0RepeatFG-GAP 7
TgeneITGA9chr3:38035463chr3:37818883ENST00000264741222830_9818471036.0Topological domainExtracellular


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Fusion Gene Sequence for VILL-ITGA9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98097_98097_1_VILL-ITGA9_VILL_chr3_38035463_ENST00000283713_ITGA9_chr3_37818883_ENST00000264741_length(transcript)=5493nt_BP=401nt
GAGGGCGGGAAGGGCCCTCTGTGGGGCTGCCATTTTGGCTGGGACCTAAATGCAGTAAAGGAGCAGCTACGGGAATATAGAGAGTGGGGC
TTCCAGGCAGAGAAGCCTGCAGTGCAAAGGTCTGCAGACAACGACCTGGGCGTCTTCAAGGGACACAAGGAATCATATTGCCAGAACACA
TTGTACAGGTAGCCAGGTGTCGGTCTCCAGCCTGAGAACTCTGGCTGTTGTTCCTTGTGTCGTCCCATATTCCTGCCTGGCCTGCGATGG
ACATCAGCAAGGGCCTCCCAGGCATGCAGGGAGGCCTCCACATATGGATCTCTGAGAACCGGAAGATGGTGCCGGTACCCGAGGGGGCTT
ACGGGAACTTTTTTGAGGAACACTGCTATGTCATCCTCCACGTGGGCCAAGAGAAGGGAAACTGCTCTTTCCAGAAAAACCCAACTCCCT
GCATCATCCCTCAAGAACAAGAAAATATCTTCCACACAATATTTGCTTTTTTCACAAAGTCTGGAAGAAAAGTCTTGGACTGTGAAAAAC
CAGGAATTTCTTGCCTAACAGCACACTGTAACTTTAGTGCTCTTGCTAAAGAAGAAAGTCGTACTATAGACATTTACATGCTGCTGAACA
CAGAAATACTGAAAAAGGACAGTTCGTCTGTCATCCAGTTCATGTCCCGCGCCAAGGTGAAGGTGGATCCTGCCCTAAGGGTGGTGGAAA
TAGCTCATGGGAACCCAGAAGAGGTGACGGTGGTCTTCGAGGCCCTGCACAATCTGGAGCCCCGTGGCTACGTCGTGGGGTGGATCATCG
CCATCAGTTTGTTGGTGGGAATCCTCATCTTCCTGCTGCTGGCCGTGCTGCTCTGGAAGATGGGCTTCTTTCGCCGAAGGTACAAAGAAA
TTATCGAAGCTGAGAAGAACCGGAAAGAGAATGAAGACAGTTGGGACTGGGTCCAGAAAAACCAGTGAGCTGCCACACCAGTCACATGAC
CTGATCACTAGCCTGTCATCCTTGGTCTTTGTATCTTCCATATTTGGAAGAAAAAAATCTTCTCCAGATTTTTCGGAGGCCCCACTGATG
CTGTTCTCTTCTTCATTCTATCAAGCCCAGGTGCCAGCCTGAGGCAGCCACTTCGGCCAGGTCACACGACCGGGGCCAGCACCACTTCCT
TTAAAGATGAACTCTGAACTTTGGAGAGTGAGCTACAGAGCCGAGCAATATTTATGGATGCAACACGCATGGTCAACCCTCAGGGGAAAA
CTGTTACCTAAAGTATTTTTATAAATATAAGCCTTTTATACTGATTATGTCTTTTATATTTGTATCGATGTTTTATTATTTCTATTAAAT
AGTTATATAATTCACTCAAGCACTGATATCTGGCCTAAAATCTTGGAAGTACATGTCCATGAATACAAATTTTAAAGGATGAAAATCTTA
CCGTACTTTGGAACTTGCTGTTTAAAAAGACAGATGAAATAAGTTGAAGAAACCTCATGTAATGAATCCACCAGGCTGGCAGTGGTGCAT
ATAAACTGTGGGTGTGGCAAGACCCCGAAGACATTTCACATCTTTATCGCCTCGATCAAGTGTGGAGTCACATGCTAATGTGTGCTAAAG
AACTGTAAGTGTTTTTTCATATGTACTTTTCATTGGAAGATTCCCAACAAGAATTTGGATGGAAAACCTGATCCCTAGCAAGAAGTCTGC
TCTGTATCACCTTTATATAGCAGACATGTCACCCTGCTTCTACACAGATGATGGATGAAAGCTTGGAGCAATGCCATGTGGTCATCTGGT
AAACCTCAGAATGGCGTCTCATCCTGGACATCCTGCATCAGAGTTCACACACCACAAGGACTAAATCCTTGTCCCCTAAGCAAAGAATTG
GGTCTGAATGCTGTGAGGGATTGCCTTTTTGTGGTAATTTTCATTGAGAGATCTTCATTTCCCCTACCACCCTGGCTGTCCCAGCTAGTG
GTGATTGCAGATTCCTTCCCAGAGAGGACATTTAACCGTTTTAAAAAAAATGTCTTAGATTGGGTTCCCAAGAAGCAGTCCCTGAAACAA
GGATTTGTGTGCAAGTAACTTATTAAGGAAGTATTCCCAGGGGATACCAGTAAGAGAGTGGGGGAAGCAGGACAAGGAAGGAGACAAAGC
CAGGCAAATGTTTGTCATTTCAGGGAGAGCTCCATGAAGTTTAGCCTCAGCCTGATCAGGGGAACTCCGGAGGAAAAGTTAGGCCTCAGA
GGTGTCCCAACCTGAATCAAGGGGCTGGCTGCACCCAGAGGAGATGTAAACGTTTTATTCTCAATTCCTGCTGGCGTAATGGCTCCAGTA
GCTCAGGACAGTCCTCTAAAGGACAACCACAGATGCATCCTCAGCCAGGGGAGACACAGGGAAATGATGCAAAAGAAATGATGCAAAGGA
TCTGAGCAGAACACTGCCCCTCCCCACCCCCTGAATGTGTGAGTGCTGAGTTACGGCCTTCAGTATCCAAGCTCTCTGTTTGACAGTAGA
TATATTGTCAGATGCACTGTGCTGCTTAGTTTTGAGTGCAGTGTGATTTTCTGAAAGGGCAATGAGATGATGGATGTAGCATGCTCAGCA
CTGACCTGGCCCATAGTGATCACTCAATAACTGTTAACAGCTATGGCTGCTATTCCTACTGATGGATAACCATCTAATAAGACAGAAAAC
ATGGGGCTAAGAGCAGGGTCTAACGGAGTCTTAATGGCTTATTACAGCCTGCCAAAGTGCCAGCTACATACACATGGCATCCAGTGCGGA
TGAAACAATCTATAAAACCAAGGGTCTTTCTTATAGCACCTTTTTTACTGGAAGCTAACACGTTGGGAGTCCGTGAACATTGTCAAAAAG
ACATCAAACTCAACTTCTGGGAAGACAGATTTTTAATACACATACTTGGCTAATACTCACAAACATATCTAAAGTTTTGGCAAAATTATG
AGGGTGATGGGTGGGTACTAACCTGGCATGGAGCAGGTGTGTCTTTTGGTTTCTTATGCAGTTGACTCTGCTGCAGGGAGATTACAGATG
TAACCTCATGCTTCTCTTCCTGGTGAACATGGGAATAGACCAAAAAAATCAAGGGTCAATGGCATGAACTAAGCTGATCCTGGAAATCAG
GGATGTTGCATCTAACTGTGGGATGGAGGCACAGAGGTAGCTACAGGGAGCAGGACGAGGCAAAGAAAGCAGCTGTCACTCAGAGTTCGC
TTATGAGTTTTATCAAAAGCAGCAAGAAAAGCAGTCTTGGGTGGGTTTTATCACTTATTAACAGCCATTTATGAGGCCCCTGCTGTGTGT
CAGGCACTGTGCAAGGTGCTGGAGGTTCCCCAGAGAACACTTCAGGGACATTTTGCCTCAGGGTGGCAAAATGCAGTGGCATGTGGACTT
TTTGAATGGGATGCCATTTGCAGCTTTCCTTTGATGGACTCTTGTTCATAATGCCATGTTTTCTTTAATGAATCATTTAGGATTCTTAGG
TGATATTTCTGGAACAGCACCATCAACAGCTTTGGCCACATGCACTTAGAGCAACTAACTTGCCTCCTGCCGGGGTGTAGGTGCGTTGGT
GACAGTGTAGAAGGGTGATTCGCAGGCCCATGTTCTGCCCACCAGCAAAGCCCCACTGGAGAAGGGTAGACTCCTGTGGGCAGTCTCAGA
GCTGGGACCTATTTGCTTCTGCTTGATTCTGCGTGGGTGGACCCACATGAGCAGCTGTATACCCAGGAGGTCACTAAGACTTTATAAAGG
CAGGTTTTAAGAAAACCAGCCTTGGCATCACCACCAGCAGATACTGAAAGCCTCCCCAGGAACCTGTCTGGGGAAGGATGATGCCTCTGC
TGGTCTGATCGTGCTGAGTAGCAGGTGGGCTACGGGGACTGGGGAGTTAAGCATTTTGTGCAGTGATAGAGAAGTCAAGCATATCGTTAG
CGCTCTCTCAACTTGGGCAGTTCACAAGCTCCTTCCCAGCTCAGAAGCCCTCTCTATGCTCTCAGGGGAAGCAGATGGGGTGGATCAGTA
CATCTGTGTTACCCTTCCAGAATATTATTTGAAAATTCTACAGTATGTTCTACTTTCTCCCCTTCCTGCTTCCATGGTTTCACTGTGGAA
TCCTATAAGATATTCTCCTGAGCAGTATTATTTCAGTTTCCTTCAGCTTTTAGTTGAATCTTCAATGTGGTTTTAACCAACTGTTCAGAG
AACTGAAATGGTTTTTAAATATGAAAAAGGACCTTTGTAAAAATGGAGTAAAACAGTGCCCCTTTTTTAAAAAAAGTTTTGCTTATGCTT
AATTTACATAGGACTCAGGAGAGTTTGGAACATCCTCCAAGTGGGCCATAGAGCTGTCACAAAGAAGAGGCCATGATGTTTAGAAACAAG
GGGACACTAGCAGGAGGGGCAGGGTCCACTGGCTTAGTGGCAACTGACAGGCATCCATTCCGAATAACTCAGCACTGAGGTTTCCTCAGG
CAGTTCTTTAGGAAAACTGTCAGCATCATGGGTACTCAGAGGTATGGTAGACCTTGTAGAAGATCCACTAGGAAGTCCTCCTTCACCAAA
TCATGTAGCTACTGCCCTTGAGCCAAAGGCAATGAGGTTTAAAACAAAAACCCAACAGCACTCCTGGGAACATCCTGTTTTCCATGCGGA
AGCATAGCAGATCCCCAGACGATCCGTGTGCTGTATGCTACCTGTTGAACCCTAGCATGGTGGCTTTTTAAAAGGTTATTTATGACTTTT
ATTTTTGGGTAAGGCATTATGGCCAGGTGCATGCAGTTATGTCTGGGTTACGTGTGAAACGTACATCTGGTGAACTGTATACTTGGCTCA
AACTTCTCAAAATTTAGAGGTGCTGGAAAGGATTGTCACTTGGAGCCTTTAGTAGACAAAAGGCAGAAAGTGAGCATCATTTCAGAAATG
CTTTAGTATGCACACTTTTAGCTGATATTTTGATATATAGAATAATAATATACACAGTGGAGAATATTCAAAGAGTGGCTGAAGGGAGAA
TACAGAGCCAGTAGGGCCAAAATGAAACTTCTAGGATGTCTTCTGAATTTTCAGCACATGGGGGGAATAAGTGAACAAATTTCCCAACAT
CGTGCAATGCTTTATAGCACAATGATCTAGATTTCAGACTGTGTTAAGGTTTTTTCTTTGTTGATGTTGTTGTTTTAATTCTAATGTGCA
CGGTGTGACTGGCAGAGTGAGTTTAAAAGCTTTACGAGTGATTAATTGCTTGGCAGGCACCCACGCTATCTGCATTTCCAGAACTTTACT
GATGCATCCATGTACATTTCCACTGAGGAATTTTGGTGGGTGGGGGGAGGTTGTGCTGCCTCACAATGTCACGTGTATTAAAGTCTAAGC
AGTCACTTCTGATTCACTTGCACTGTTTGGGAAATGTCAGGTTTACAAAAACATACATGTTTGGAATAAAAAATGGCTGCAAACAATTCA

>98097_98097_1_VILL-ITGA9_VILL_chr3_38035463_ENST00000283713_ITGA9_chr3_37818883_ENST00000264741_length(amino acids)=247AA_BP=57
MLFLVSSHIPAWPAMDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVGQEKGNCSFQKNPTPCIIPQEQENIFHTIF
AFFTKSGRKVLDCEKPGISCLTAHCNFSALAKEESRTIDIYMLLNTEILKKDSSSVIQFMSRAKVKVDPALRVVEIAHGNPEEVTVVFEA

--------------------------------------------------------------
>98097_98097_2_VILL-ITGA9_VILL_chr3_38035463_ENST00000383759_ITGA9_chr3_37818883_ENST00000264741_length(transcript)=5313nt_BP=221nt
TTGTACAGGTAGCCAGGTGTCGGTCTCCAGCCTGAGAACTCTGGCTGTTGTTCCTTGTGTCGTCCCATATTCCTGCCTGGCCTGCGATGG
ACATCAGCAAGGGCCTCCCAGGCATGCAGGGAGGCCTCCACATATGGATCTCTGAGAACCGGAAGATGGTGCCGGTACCCGAGGGGGCTT
ACGGGAACTTTTTTGAGGAACACTGCTATGTCATCCTCCACGTGGGCCAAGAGAAGGGAAACTGCTCTTTCCAGAAAAACCCAACTCCCT
GCATCATCCCTCAAGAACAAGAAAATATCTTCCACACAATATTTGCTTTTTTCACAAAGTCTGGAAGAAAAGTCTTGGACTGTGAAAAAC
CAGGAATTTCTTGCCTAACAGCACACTGTAACTTTAGTGCTCTTGCTAAAGAAGAAAGTCGTACTATAGACATTTACATGCTGCTGAACA
CAGAAATACTGAAAAAGGACAGTTCGTCTGTCATCCAGTTCATGTCCCGCGCCAAGGTGAAGGTGGATCCTGCCCTAAGGGTGGTGGAAA
TAGCTCATGGGAACCCAGAAGAGGTGACGGTGGTCTTCGAGGCCCTGCACAATCTGGAGCCCCGTGGCTACGTCGTGGGGTGGATCATCG
CCATCAGTTTGTTGGTGGGAATCCTCATCTTCCTGCTGCTGGCCGTGCTGCTCTGGAAGATGGGCTTCTTTCGCCGAAGGTACAAAGAAA
TTATCGAAGCTGAGAAGAACCGGAAAGAGAATGAAGACAGTTGGGACTGGGTCCAGAAAAACCAGTGAGCTGCCACACCAGTCACATGAC
CTGATCACTAGCCTGTCATCCTTGGTCTTTGTATCTTCCATATTTGGAAGAAAAAAATCTTCTCCAGATTTTTCGGAGGCCCCACTGATG
CTGTTCTCTTCTTCATTCTATCAAGCCCAGGTGCCAGCCTGAGGCAGCCACTTCGGCCAGGTCACACGACCGGGGCCAGCACCACTTCCT
TTAAAGATGAACTCTGAACTTTGGAGAGTGAGCTACAGAGCCGAGCAATATTTATGGATGCAACACGCATGGTCAACCCTCAGGGGAAAA
CTGTTACCTAAAGTATTTTTATAAATATAAGCCTTTTATACTGATTATGTCTTTTATATTTGTATCGATGTTTTATTATTTCTATTAAAT
AGTTATATAATTCACTCAAGCACTGATATCTGGCCTAAAATCTTGGAAGTACATGTCCATGAATACAAATTTTAAAGGATGAAAATCTTA
CCGTACTTTGGAACTTGCTGTTTAAAAAGACAGATGAAATAAGTTGAAGAAACCTCATGTAATGAATCCACCAGGCTGGCAGTGGTGCAT
ATAAACTGTGGGTGTGGCAAGACCCCGAAGACATTTCACATCTTTATCGCCTCGATCAAGTGTGGAGTCACATGCTAATGTGTGCTAAAG
AACTGTAAGTGTTTTTTCATATGTACTTTTCATTGGAAGATTCCCAACAAGAATTTGGATGGAAAACCTGATCCCTAGCAAGAAGTCTGC
TCTGTATCACCTTTATATAGCAGACATGTCACCCTGCTTCTACACAGATGATGGATGAAAGCTTGGAGCAATGCCATGTGGTCATCTGGT
AAACCTCAGAATGGCGTCTCATCCTGGACATCCTGCATCAGAGTTCACACACCACAAGGACTAAATCCTTGTCCCCTAAGCAAAGAATTG
GGTCTGAATGCTGTGAGGGATTGCCTTTTTGTGGTAATTTTCATTGAGAGATCTTCATTTCCCCTACCACCCTGGCTGTCCCAGCTAGTG
GTGATTGCAGATTCCTTCCCAGAGAGGACATTTAACCGTTTTAAAAAAAATGTCTTAGATTGGGTTCCCAAGAAGCAGTCCCTGAAACAA
GGATTTGTGTGCAAGTAACTTATTAAGGAAGTATTCCCAGGGGATACCAGTAAGAGAGTGGGGGAAGCAGGACAAGGAAGGAGACAAAGC
CAGGCAAATGTTTGTCATTTCAGGGAGAGCTCCATGAAGTTTAGCCTCAGCCTGATCAGGGGAACTCCGGAGGAAAAGTTAGGCCTCAGA
GGTGTCCCAACCTGAATCAAGGGGCTGGCTGCACCCAGAGGAGATGTAAACGTTTTATTCTCAATTCCTGCTGGCGTAATGGCTCCAGTA
GCTCAGGACAGTCCTCTAAAGGACAACCACAGATGCATCCTCAGCCAGGGGAGACACAGGGAAATGATGCAAAAGAAATGATGCAAAGGA
TCTGAGCAGAACACTGCCCCTCCCCACCCCCTGAATGTGTGAGTGCTGAGTTACGGCCTTCAGTATCCAAGCTCTCTGTTTGACAGTAGA
TATATTGTCAGATGCACTGTGCTGCTTAGTTTTGAGTGCAGTGTGATTTTCTGAAAGGGCAATGAGATGATGGATGTAGCATGCTCAGCA
CTGACCTGGCCCATAGTGATCACTCAATAACTGTTAACAGCTATGGCTGCTATTCCTACTGATGGATAACCATCTAATAAGACAGAAAAC
ATGGGGCTAAGAGCAGGGTCTAACGGAGTCTTAATGGCTTATTACAGCCTGCCAAAGTGCCAGCTACATACACATGGCATCCAGTGCGGA
TGAAACAATCTATAAAACCAAGGGTCTTTCTTATAGCACCTTTTTTACTGGAAGCTAACACGTTGGGAGTCCGTGAACATTGTCAAAAAG
ACATCAAACTCAACTTCTGGGAAGACAGATTTTTAATACACATACTTGGCTAATACTCACAAACATATCTAAAGTTTTGGCAAAATTATG
AGGGTGATGGGTGGGTACTAACCTGGCATGGAGCAGGTGTGTCTTTTGGTTTCTTATGCAGTTGACTCTGCTGCAGGGAGATTACAGATG
TAACCTCATGCTTCTCTTCCTGGTGAACATGGGAATAGACCAAAAAAATCAAGGGTCAATGGCATGAACTAAGCTGATCCTGGAAATCAG
GGATGTTGCATCTAACTGTGGGATGGAGGCACAGAGGTAGCTACAGGGAGCAGGACGAGGCAAAGAAAGCAGCTGTCACTCAGAGTTCGC
TTATGAGTTTTATCAAAAGCAGCAAGAAAAGCAGTCTTGGGTGGGTTTTATCACTTATTAACAGCCATTTATGAGGCCCCTGCTGTGTGT
CAGGCACTGTGCAAGGTGCTGGAGGTTCCCCAGAGAACACTTCAGGGACATTTTGCCTCAGGGTGGCAAAATGCAGTGGCATGTGGACTT
TTTGAATGGGATGCCATTTGCAGCTTTCCTTTGATGGACTCTTGTTCATAATGCCATGTTTTCTTTAATGAATCATTTAGGATTCTTAGG
TGATATTTCTGGAACAGCACCATCAACAGCTTTGGCCACATGCACTTAGAGCAACTAACTTGCCTCCTGCCGGGGTGTAGGTGCGTTGGT
GACAGTGTAGAAGGGTGATTCGCAGGCCCATGTTCTGCCCACCAGCAAAGCCCCACTGGAGAAGGGTAGACTCCTGTGGGCAGTCTCAGA
GCTGGGACCTATTTGCTTCTGCTTGATTCTGCGTGGGTGGACCCACATGAGCAGCTGTATACCCAGGAGGTCACTAAGACTTTATAAAGG
CAGGTTTTAAGAAAACCAGCCTTGGCATCACCACCAGCAGATACTGAAAGCCTCCCCAGGAACCTGTCTGGGGAAGGATGATGCCTCTGC
TGGTCTGATCGTGCTGAGTAGCAGGTGGGCTACGGGGACTGGGGAGTTAAGCATTTTGTGCAGTGATAGAGAAGTCAAGCATATCGTTAG
CGCTCTCTCAACTTGGGCAGTTCACAAGCTCCTTCCCAGCTCAGAAGCCCTCTCTATGCTCTCAGGGGAAGCAGATGGGGTGGATCAGTA
CATCTGTGTTACCCTTCCAGAATATTATTTGAAAATTCTACAGTATGTTCTACTTTCTCCCCTTCCTGCTTCCATGGTTTCACTGTGGAA
TCCTATAAGATATTCTCCTGAGCAGTATTATTTCAGTTTCCTTCAGCTTTTAGTTGAATCTTCAATGTGGTTTTAACCAACTGTTCAGAG
AACTGAAATGGTTTTTAAATATGAAAAAGGACCTTTGTAAAAATGGAGTAAAACAGTGCCCCTTTTTTAAAAAAAGTTTTGCTTATGCTT
AATTTACATAGGACTCAGGAGAGTTTGGAACATCCTCCAAGTGGGCCATAGAGCTGTCACAAAGAAGAGGCCATGATGTTTAGAAACAAG
GGGACACTAGCAGGAGGGGCAGGGTCCACTGGCTTAGTGGCAACTGACAGGCATCCATTCCGAATAACTCAGCACTGAGGTTTCCTCAGG
CAGTTCTTTAGGAAAACTGTCAGCATCATGGGTACTCAGAGGTATGGTAGACCTTGTAGAAGATCCACTAGGAAGTCCTCCTTCACCAAA
TCATGTAGCTACTGCCCTTGAGCCAAAGGCAATGAGGTTTAAAACAAAAACCCAACAGCACTCCTGGGAACATCCTGTTTTCCATGCGGA
AGCATAGCAGATCCCCAGACGATCCGTGTGCTGTATGCTACCTGTTGAACCCTAGCATGGTGGCTTTTTAAAAGGTTATTTATGACTTTT
ATTTTTGGGTAAGGCATTATGGCCAGGTGCATGCAGTTATGTCTGGGTTACGTGTGAAACGTACATCTGGTGAACTGTATACTTGGCTCA
AACTTCTCAAAATTTAGAGGTGCTGGAAAGGATTGTCACTTGGAGCCTTTAGTAGACAAAAGGCAGAAAGTGAGCATCATTTCAGAAATG
CTTTAGTATGCACACTTTTAGCTGATATTTTGATATATAGAATAATAATATACACAGTGGAGAATATTCAAAGAGTGGCTGAAGGGAGAA
TACAGAGCCAGTAGGGCCAAAATGAAACTTCTAGGATGTCTTCTGAATTTTCAGCACATGGGGGGAATAAGTGAACAAATTTCCCAACAT
CGTGCAATGCTTTATAGCACAATGATCTAGATTTCAGACTGTGTTAAGGTTTTTTCTTTGTTGATGTTGTTGTTTTAATTCTAATGTGCA
CGGTGTGACTGGCAGAGTGAGTTTAAAAGCTTTACGAGTGATTAATTGCTTGGCAGGCACCCACGCTATCTGCATTTCCAGAACTTTACT
GATGCATCCATGTACATTTCCACTGAGGAATTTTGGTGGGTGGGGGGAGGTTGTGCTGCCTCACAATGTCACGTGTATTAAAGTCTAAGC
AGTCACTTCTGATTCACTTGCACTGTTTGGGAAATGTCAGGTTTACAAAAACATACATGTTTGGAATAAAAAATGGCTGCAAACAATTCA

>98097_98097_2_VILL-ITGA9_VILL_chr3_38035463_ENST00000383759_ITGA9_chr3_37818883_ENST00000264741_length(amino acids)=247AA_BP=57
MLFLVSSHIPAWPAMDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVGQEKGNCSFQKNPTPCIIPQEQENIFHTIF
AFFTKSGRKVLDCEKPGISCLTAHCNFSALAKEESRTIDIYMLLNTEILKKDSSSVIQFMSRAKVKVDPALRVVEIAHGNPEEVTVVFEA

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Fusion Gene PPI Analysis for VILL-ITGA9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VILL-ITGA9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VILL-ITGA9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource