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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:VIM-IQCG (FusionGDB2 ID:98114)

Fusion Gene Summary for VIM-IQCG

Fusion gene summary

Fusion gene information	Fusion gene name: VIM-IQCG
	Fusion gene ID: 98114
		Hgene	Tgene
	Gene symbol	VIM	IQCG
	Gene ID	7431	84223
	Gene name	vimentin	IQ motif containing G
	Synonyms	-	CFAP122\|DRC9
	Cytomap	10p13	3q29
	Type of gene	protein-coding	protein-coding
	Description	vimentinepididymis secretory sperm binding protein	dynein regulatory complex protein 9IQ domain-containing protein Gdynein regulatory complex subunit 9
	Modification date	20200327	20200313
	UniProtAcc	.	Q9H095
	Ensembl transtripts involved in fusion gene	ENST00000224237, ENST00000544301, ENST00000485947,	ENST00000453254, ENST00000455191, ENST00000480302, ENST00000265239,
Fusion gene scores	* DoF score	38 X 18 X 13=8892	12 X 7 X 6=504
	# samples	42	12
	** MAII score	log2(42/8892*10)=-4.40404671536087 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/504*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: VIM [Title/Abstract] AND IQCG [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	VIM(17276823)-IQCG(197686891), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across VIM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IQCG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CV328902	VIM	chr10	17276823	+	IQCG	chr3	197686891	-

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Fusion Gene ORF analysis for VIM-IQCG

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000224237	ENST00000453254	VIM	chr10	17276823	+	IQCG	chr3	197686891	-
5CDS-intron	ENST00000224237	ENST00000455191	VIM	chr10	17276823	+	IQCG	chr3	197686891	-
5CDS-intron	ENST00000224237	ENST00000480302	VIM	chr10	17276823	+	IQCG	chr3	197686891	-
5CDS-intron	ENST00000544301	ENST00000453254	VIM	chr10	17276823	+	IQCG	chr3	197686891	-
5CDS-intron	ENST00000544301	ENST00000455191	VIM	chr10	17276823	+	IQCG	chr3	197686891	-
5CDS-intron	ENST00000544301	ENST00000480302	VIM	chr10	17276823	+	IQCG	chr3	197686891	-
In-frame	ENST00000224237	ENST00000265239	VIM	chr10	17276823	+	IQCG	chr3	197686891	-
In-frame	ENST00000544301	ENST00000265239	VIM	chr10	17276823	+	IQCG	chr3	197686891	-
intron-3CDS	ENST00000485947	ENST00000265239	VIM	chr10	17276823	+	IQCG	chr3	197686891	-
intron-intron	ENST00000485947	ENST00000453254	VIM	chr10	17276823	+	IQCG	chr3	197686891	-
intron-intron	ENST00000485947	ENST00000455191	VIM	chr10	17276823	+	IQCG	chr3	197686891	-
intron-intron	ENST00000485947	ENST00000480302	VIM	chr10	17276823	+	IQCG	chr3	197686891	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000544301

VIM

chr10

17276823

ENST00000265239

IQCG

chr3

197686891

3683

1421

1846

3177

443

ENST00000224237

VIM

chr10

17276823

ENST00000265239

IQCG

chr3

197686891

3415

1153

1578

2909

443

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000544301	ENST00000265239	VIM	chr10	17276823	+	IQCG	chr3	197686891	-	0.001888729	0.99811125
ENST00000224237	ENST00000265239	VIM	chr10	17276823	+	IQCG	chr3	197686891	-	0.001728814	0.9982712

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Fusion Genomic Features for VIM-IQCG

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
VIM	chr10	17276817	+	IQCG	chr3	197686892	-	1.85E-09	1
VIM	chr10	17276817	+	IQCG	chr3	197686892	-	1.85E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VIM-IQCG

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:17276823/chr3:197686891)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	IQCG Q9H095
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. {ECO:0000250\|UniProtKB:A3KQH2, ECO:0000250\|UniProtKB:A8HQ54, ECO:0000250\|UniProtKB:Q80W32}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000224237

154_245

336

467.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000224237

96_131

336

467.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000544301

154_245

336

467.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000544301

96_131

336

467.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000224237

326_329

336

467.0

Motif

[IL]-x-C-x-x-[DE] motif

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000544301

326_329

336

467.0

Motif

[IL]-x-C-x-x-[DE] motif

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000224237

132_153

336

467.0

Region

Note=Linker 1

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000224237

246_268

336

467.0

Region

Note=Linker 12

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000224237

2_95

336

467.0

Region

Note=Head

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000544301

132_153

336

467.0

Region

Note=Linker 1

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000544301

246_268

336

467.0

Region

Note=Linker 12

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000544301

2_95

336

467.0

Region

Note=Head

Tgene

IQCG

chr10:17276823

chr3:197686891

ENST00000265239

-1

393_422

444.0

Domain

Tgene

IQCG

chr10:17276823

chr3:197686891

ENST00000455191

393_422

444.0

Domain

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000224237

303_407

336

467.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000544301

303_407

336

467.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000224237

103_411

336

467.0

Domain

IF rod

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000544301

103_411

336

467.0

Domain

IF rod

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000224237

269_407

336

467.0

Region

Note=Coil 2

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000224237

408_466

336

467.0

Region

Note=Tail

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000544301

269_407

336

467.0

Region

Note=Coil 2

Hgene

VIM

chr10:17276823

chr3:197686891

ENST00000544301

408_466

336

467.0

Region

Note=Tail

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Fusion Gene Sequence for VIM-IQCG

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>98114_98114_1_VIM-IQCG_VIM_chr10_17276823_ENST00000224237_IQCG_chr3_197686891_ENST00000265239_length(transcript)=3415nt_BP=1153nt
CTCTGCCACTCTCGCTCCGAGGTCCCCGCGCCAGAGACGCAGCCGCGCTCCCACCACCCACACCCACCGCGCCCTCGTTCGCCTCTTCTC
CGGGAGCCAGTCCGCGCCACCGCCGCCGCCCAGGCCATCGCCACCCTCCGCAGCCATGTCCACCAGGTCCGTGTCCTCGTCCTCCTACCG
CAGGATGTTCGGCGGCCCGGGCACCGCGAGCCGGCCGAGCTCCAGCCGGAGCTACGTGACTACGTCCACCCGCACCTACAGCCTGGGCAG
CGCGCTGCGCCCCAGCACCAGCCGCAGCCTCTACGCCTCGTCCCCGGGCGGCGTGTATGCCACGCGCTCCTCTGCCGTGCGCCTGCGGAG
CAGCGTGCCCGGGGTGCGGCTCCTGCAGGACTCGGTGGACTTCTCGCTGGCCGACGCCATCAACACCGAGTTCAAGAACACCCGCACCAA
CGAGAAGGTGGAGCTGCAGGAGCTGAATGACCGCTTCGCCAACTACATCGACAAGGTGCGCTTCCTGGAGCAGCAGAATAAGATCCTGCT
GGCCGAGCTCGAGCAGCTCAAGGGCCAAGGCAAGTCGCGCCTGGGGGACCTCTACGAGGAGGAGATGCGGGAGCTGCGCCGGCAGGTGGA
CCAGCTAACCAACGACAAAGCCCGCGTCGAGGTGGAGCGCGACAACCTGGCCGAGGACATCATGCGCCTCCGGGAGAAATTGCAGGAGGA
GATGCTTCAGAGAGAGGAAGCCGAAAACACCCTGCAATCTTTCAGACAGGATGTTGACAATGCGTCTCTGGCACGTCTTGACCTTGAACG
CAAAGTGGAATCTTTGCAAGAAGAGATTGCCTTTTTGAAGAAACTCCACGAAGAGGAAATCCAGGAGCTGCAGGCTCAGATTCAGGAACA
GCATGTCCAAATCGATGTGGATGTTTCCAAGCCTGACCTCACGGCTGCCCTGCGTGACGTACGTCAGCAATATGAAAGTGTGGCTGCCAA
GAACCTGCAGGAGGCAGAAGAATGGTACAAATCCAAGTTTGCTGACCTCTCTGAGGCTGCCAACCGGAACAATGACGCCCTGCGCCAGGC
AAAGCAGGAGTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCACCTGTGAAGTGGATGCCCTTAAAGGAACCGAGTGGGGCTGTGGGAG
GAAGAAAGGCTAGCGGGCGTTGGCCGTATGTGGGTGTCTTGAGGCAGTTTTTCAGTTCTTTCATTTACCAAAGTGACATGCACCTACTAG
GTGCCAGGTGTTTAGACGTACATACAACCCTCTGCAAAATCTTTCAGTGTAGTCCTCTGTATGAAAAGTTTCCAGCCAAGAATTGCCACT
GCACCTGAGATAAGGGGGATCCTGGCCATTAAGGAAACCTTGCCTTCGAAACTGAGCCGTGAGGAACTATACAAAATGGGAAATTGGGAC
AAATCCCAGTGGCTCATGACACTAAGAAGTAAAATTACGAACTCACTGAGCTGGAAGTCATTCAACGGGAATTGAATAGGTAACTGCACT
TTTGTGAGATTATAAATATACCACGGAGGGTAACGAAGCTACAGAAGAATGGAAGAAGACAGCCTGGAAGACTCAAACCTTCCTCCAAAA
GTTTGGCATTCTGAGATGACGGTGTCAGTGACAGGCGAACCACCTAGTACCGTAGAAGAAGAAGGAATACCTAAAGAAACAGACATAGAA
ATCATCCCAGAAATCCCGGAAACTCTAGAGCCACTGTCCCTTCCAGATGTGCTGAGGATCTCGGCAGTTCTGGAGGACACCACAGACCAG
CTCTCTATTCTGAACTACATCATGCCCGTTCAGTACGAAGGGAGACAGAGCATCTGCGTGAAAAGCAGAGAAATGAATCTAGAAGGAACG
AATCTAGACAAACTTCCAATGGCCTCAACAATCACAAAAATACCCAGTCCGTTAATAACTGAGGAAGGACCCAACTTGCCAGAAATCAGA
CACAGAGGCCGGTTCGCTGTGGAGTTTAACAAAATGCAGGATCTTGTCTTCAAAAAACCTACAAGGCAGACCATCATGACTACGGAGACA
CTGAAGAAAATTCAGATTGATAGGCAGTTTTTCAGCGATGTGATTGCAGATACCATTAAGGAGTTGCAAGATTCGGCCACTTACAACAGT
CTCCTGCAAGCTTTGAGCAAAGAGAGGGAAAACAAAATGCATTTCTATGACATCATTGCCAGGGAGGAAAAAGGAAGAAAACAGATAATA
TCACTTCAAAAACAGCTAATTAATGTCAAAAAGGAATGGCAATTTGAAGTCCAGAGTCAGAATGAGTATATTGCTAACCTCAAGGACCAA
CTGCAAGAGATGAAGGCAAAATCCAACTTGGAGAATCGCTACATGAAAACCAATACCGAGCTGCAGATTGCCCAGACCCAGAAAAAGTGT
AACAGAACAGAGGAACTCTTGGTGGAAGAGATTGAGAAACTCAGGATGAAAACCGAAGAAGAGGCCCGGACTCATACAGAGATTGAAATG
TTCCTTAGAAAGGAGCAGCAGAAACTTGAGGAGAGGCTGGAGTTCTGGATGGAGAAATACGATAAGGACACAGAAATGAAACAGAATGAA
CTAAATGCTCTCAAAGCCACAAAGGCCAGTGACTTAGCACACCTTCAAGACCTGGCAAAGATGATAAGAGAGTATGAACAGGTCATCATT
GAAGATCGTATAGAAAAGGAGAGGAGCAAGAAGAAGGTAAAACAGGATCTCTTGGAATTAAAGAGCGTTATAAAGCTCCAGGCCTGGTGG
CGAGGCACTATGATACGGAGAGAAATTGGTGGTTTCAAGATGCCTAAAGACAAAGTTGATAGCAAGGATTCAAAAGGCAAAGGTAAAGGC
AAGGATAAGAGGAGAGGCAAGAAGAAGTGACCAAGTTCTCTTTTGTGTTTTCTGCTGGTATTCTGGAGGTGGGAAGGACTTGGAGAGAGT
TAAGAAACACCTGGTACCTCAAAGATGACTCATCTACAGGTTGTTTCCTATTGAGACTTTCCCAGGGAAGCCTGATTTCACTTTGCCTGT
TAATTTCACTCTGCCTGTTAGGTGGGTTTTCAAACCCTGATTTAGGATTACACCATTGACTTAGGGCTTCCTCATACCTTGCTGGGAAGA
AGTTTCTAGTAGTCCTGTGAAGATTCATTCTTCTTGCTCTTTCTCAGCAGAACAAAGGAGTTCACTGGCTTAGCTACAGTGACGCATTGA
AACTTGAGTAATTCCTGTAATGTCAGATTTTGATTTTACCCAATTTGTCTGTAGTGAAAAAACTCTTATGAGCAAAAGTATTCAGTAGGA

>98114_98114_1_VIM-IQCG_VIM_chr10_17276823_ENST00000224237_IQCG_chr3_197686891_ENST00000265239_length(amino acids)=443AA_BP=
MEEDSLEDSNLPPKVWHSEMTVSVTGEPPSTVEEEGIPKETDIEIIPEIPETLEPLSLPDVLRISAVLEDTTDQLSILNYIMPVQYEGRQ
SICVKSREMNLEGTNLDKLPMASTITKIPSPLITEEGPNLPEIRHRGRFAVEFNKMQDLVFKKPTRQTIMTTETLKKIQIDRQFFSDVIA
DTIKELQDSATYNSLLQALSKERENKMHFYDIIAREEKGRKQIISLQKQLINVKKEWQFEVQSQNEYIANLKDQLQEMKAKSNLENRYMK
TNTELQIAQTQKKCNRTEELLVEEIEKLRMKTEEEARTHTEIEMFLRKEQQKLEERLEFWMEKYDKDTEMKQNELNALKATKASDLAHLQ

--------------------------------------------------------------
>98114_98114_2_VIM-IQCG_VIM_chr10_17276823_ENST00000544301_IQCG_chr3_197686891_ENST00000265239_length(transcript)=3683nt_BP=1421nt
GCCTCTCCAAAGGCTGCAGAAGTTTCTTGCTAACAAAAAGTCCGCACATTCGAGCAAAGACAGGCTTTAGCGAGTTATTAAAAACTTAGG
GGCGCTCTTGTCCCCCACAGGGCCCGACCGCACACAGCAAGGCGATGGCCCAGCTGTAAGTTGGTAGCACTGAGAACTAGCAGCGCGCGC
GGAGCCCGCTGAGACTTGAATCAATCTGGTCTAACGGTTTCCCCTAAACCGCTAGGAGCCCTCAATCGGCGGGACAGCAGGGCGCGTCCT
CTGCCACTCTCGCTCCGAGGTCCCCGCGCCAGAGACGCAGCCGCGCTCCCACCACCCACACCCACCGCGCCCTCGTTCGCCTCTTCTCCG
GGAGCCAGTCCGCGCCACCGCCGCCGCCCAGGCCATCGCCACCCTCCGCAGCCATGTCCACCAGGTCCGTGTCCTCGTCCTCCTACCGCA
GGATGTTCGGCGGCCCGGGCACCGCGAGCCGGCCGAGCTCCAGCCGGAGCTACGTGACTACGTCCACCCGCACCTACAGCCTGGGCAGCG
CGCTGCGCCCCAGCACCAGCCGCAGCCTCTACGCCTCGTCCCCGGGCGGCGTGTATGCCACGCGCTCCTCTGCCGTGCGCCTGCGGAGCA
GCGTGCCCGGGGTGCGGCTCCTGCAGGACTCGGTGGACTTCTCGCTGGCCGACGCCATCAACACCGAGTTCAAGAACACCCGCACCAACG
AGAAGGTGGAGCTGCAGGAGCTGAATGACCGCTTCGCCAACTACATCGACAAGGTGCGCTTCCTGGAGCAGCAGAATAAGATCCTGCTGG
CCGAGCTCGAGCAGCTCAAGGGCCAAGGCAAGTCGCGCCTGGGGGACCTCTACGAGGAGGAGATGCGGGAGCTGCGCCGGCAGGTGGACC
AGCTAACCAACGACAAAGCCCGCGTCGAGGTGGAGCGCGACAACCTGGCCGAGGACATCATGCGCCTCCGGGAGAAATTGCAGGAGGAGA
TGCTTCAGAGAGAGGAAGCCGAAAACACCCTGCAATCTTTCAGACAGGATGTTGACAATGCGTCTCTGGCACGTCTTGACCTTGAACGCA
AAGTGGAATCTTTGCAAGAAGAGATTGCCTTTTTGAAGAAACTCCACGAAGAGGAAATCCAGGAGCTGCAGGCTCAGATTCAGGAACAGC
ATGTCCAAATCGATGTGGATGTTTCCAAGCCTGACCTCACGGCTGCCCTGCGTGACGTACGTCAGCAATATGAAAGTGTGGCTGCCAAGA
ACCTGCAGGAGGCAGAAGAATGGTACAAATCCAAGTTTGCTGACCTCTCTGAGGCTGCCAACCGGAACAATGACGCCCTGCGCCAGGCAA
AGCAGGAGTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCACCTGTGAAGTGGATGCCCTTAAAGGAACCGAGTGGGGCTGTGGGAGGA
AGAAAGGCTAGCGGGCGTTGGCCGTATGTGGGTGTCTTGAGGCAGTTTTTCAGTTCTTTCATTTACCAAAGTGACATGCACCTACTAGGT
GCCAGGTGTTTAGACGTACATACAACCCTCTGCAAAATCTTTCAGTGTAGTCCTCTGTATGAAAAGTTTCCAGCCAAGAATTGCCACTGC
ACCTGAGATAAGGGGGATCCTGGCCATTAAGGAAACCTTGCCTTCGAAACTGAGCCGTGAGGAACTATACAAAATGGGAAATTGGGACAA
ATCCCAGTGGCTCATGACACTAAGAAGTAAAATTACGAACTCACTGAGCTGGAAGTCATTCAACGGGAATTGAATAGGTAACTGCACTTT
TGTGAGATTATAAATATACCACGGAGGGTAACGAAGCTACAGAAGAATGGAAGAAGACAGCCTGGAAGACTCAAACCTTCCTCCAAAAGT
TTGGCATTCTGAGATGACGGTGTCAGTGACAGGCGAACCACCTAGTACCGTAGAAGAAGAAGGAATACCTAAAGAAACAGACATAGAAAT
CATCCCAGAAATCCCGGAAACTCTAGAGCCACTGTCCCTTCCAGATGTGCTGAGGATCTCGGCAGTTCTGGAGGACACCACAGACCAGCT
CTCTATTCTGAACTACATCATGCCCGTTCAGTACGAAGGGAGACAGAGCATCTGCGTGAAAAGCAGAGAAATGAATCTAGAAGGAACGAA
TCTAGACAAACTTCCAATGGCCTCAACAATCACAAAAATACCCAGTCCGTTAATAACTGAGGAAGGACCCAACTTGCCAGAAATCAGACA
CAGAGGCCGGTTCGCTGTGGAGTTTAACAAAATGCAGGATCTTGTCTTCAAAAAACCTACAAGGCAGACCATCATGACTACGGAGACACT
GAAGAAAATTCAGATTGATAGGCAGTTTTTCAGCGATGTGATTGCAGATACCATTAAGGAGTTGCAAGATTCGGCCACTTACAACAGTCT
CCTGCAAGCTTTGAGCAAAGAGAGGGAAAACAAAATGCATTTCTATGACATCATTGCCAGGGAGGAAAAAGGAAGAAAACAGATAATATC
ACTTCAAAAACAGCTAATTAATGTCAAAAAGGAATGGCAATTTGAAGTCCAGAGTCAGAATGAGTATATTGCTAACCTCAAGGACCAACT
GCAAGAGATGAAGGCAAAATCCAACTTGGAGAATCGCTACATGAAAACCAATACCGAGCTGCAGATTGCCCAGACCCAGAAAAAGTGTAA
CAGAACAGAGGAACTCTTGGTGGAAGAGATTGAGAAACTCAGGATGAAAACCGAAGAAGAGGCCCGGACTCATACAGAGATTGAAATGTT
CCTTAGAAAGGAGCAGCAGAAACTTGAGGAGAGGCTGGAGTTCTGGATGGAGAAATACGATAAGGACACAGAAATGAAACAGAATGAACT
AAATGCTCTCAAAGCCACAAAGGCCAGTGACTTAGCACACCTTCAAGACCTGGCAAAGATGATAAGAGAGTATGAACAGGTCATCATTGA
AGATCGTATAGAAAAGGAGAGGAGCAAGAAGAAGGTAAAACAGGATCTCTTGGAATTAAAGAGCGTTATAAAGCTCCAGGCCTGGTGGCG
AGGCACTATGATACGGAGAGAAATTGGTGGTTTCAAGATGCCTAAAGACAAAGTTGATAGCAAGGATTCAAAAGGCAAAGGTAAAGGCAA
GGATAAGAGGAGAGGCAAGAAGAAGTGACCAAGTTCTCTTTTGTGTTTTCTGCTGGTATTCTGGAGGTGGGAAGGACTTGGAGAGAGTTA
AGAAACACCTGGTACCTCAAAGATGACTCATCTACAGGTTGTTTCCTATTGAGACTTTCCCAGGGAAGCCTGATTTCACTTTGCCTGTTA
ATTTCACTCTGCCTGTTAGGTGGGTTTTCAAACCCTGATTTAGGATTACACCATTGACTTAGGGCTTCCTCATACCTTGCTGGGAAGAAG
TTTCTAGTAGTCCTGTGAAGATTCATTCTTCTTGCTCTTTCTCAGCAGAACAAAGGAGTTCACTGGCTTAGCTACAGTGACGCATTGAAA
CTTGAGTAATTCCTGTAATGTCAGATTTTGATTTTACCCAATTTGTCTGTAGTGAAAAAACTCTTATGAGCAAAAGTATTCAGTAGGAAT

>98114_98114_2_VIM-IQCG_VIM_chr10_17276823_ENST00000544301_IQCG_chr3_197686891_ENST00000265239_length(amino acids)=443AA_BP=
MEEDSLEDSNLPPKVWHSEMTVSVTGEPPSTVEEEGIPKETDIEIIPEIPETLEPLSLPDVLRISAVLEDTTDQLSILNYIMPVQYEGRQ
SICVKSREMNLEGTNLDKLPMASTITKIPSPLITEEGPNLPEIRHRGRFAVEFNKMQDLVFKKPTRQTIMTTETLKKIQIDRQFFSDVIA
DTIKELQDSATYNSLLQALSKERENKMHFYDIIAREEKGRKQIISLQKQLINVKKEWQFEVQSQNEYIANLKDQLQEMKAKSNLENRYMK
TNTELQIAQTQKKCNRTEELLVEEIEKLRMKTEEEARTHTEIEMFLRKEQQKLEERLEFWMEKYDKDTEMKQNELNALKATKASDLAHLQ

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Fusion Gene PPI Analysis for VIM-IQCG

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for VIM-IQCG

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for VIM-IQCG

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source