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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:VMP1-APPBP2 (FusionGDB2 ID:98193) |
Fusion Gene Summary for VMP1-APPBP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VMP1-APPBP2 | Fusion gene ID: 98193 | Hgene | Tgene | Gene symbol | VMP1 | APPBP2 | Gene ID | 81671 | 10513 |
| Gene name | vacuole membrane protein 1 | amyloid beta precursor protein binding protein 2 | |
| Synonyms | EPG3|TANGO5|TMEM49 | APP-BP2|HS.84084|PAT1 | |
| Cytomap | 17q23.1 | 17q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog | amyloid protein-binding protein 2amyloid beta precursor protein (cytoplasmic tail) binding protein 2protein interacting with APP tail 1 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | . | Q92624 | |
| Ensembl transtripts involved in fusion gene | ENST00000262291, ENST00000536180, ENST00000545362, ENST00000539763, ENST00000537567, ENST00000588617, | ENST00000592995, ENST00000083182, | |
| Fusion gene scores | * DoF score | 34 X 17 X 12=6936 | 10 X 7 X 7=490 |
| # samples | 38 | 11 | |
| ** MAII score | log2(38/6936*10)=-4.19003257489089 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/490*10)=-2.15527822547791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: VMP1 [Title/Abstract] AND APPBP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | VMP1(57816308)-APPBP2(58577848), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | APPBP2 | GO:0046907 | intracellular transport | 9843960 |
| Fusion gene breakpoints across VMP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across APPBP2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | COAD | TCGA-AZ-4323-01A | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - |
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Fusion Gene ORF analysis for VMP1-APPBP2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000262291 | ENST00000592995 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - |
| 5CDS-intron | ENST00000536180 | ENST00000592995 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - |
| 5CDS-intron | ENST00000545362 | ENST00000592995 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - |
| 5UTR-3CDS | ENST00000539763 | ENST00000083182 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - |
| 5UTR-intron | ENST00000539763 | ENST00000592995 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - |
| In-frame | ENST00000262291 | ENST00000083182 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - |
| In-frame | ENST00000536180 | ENST00000083182 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - |
| In-frame | ENST00000545362 | ENST00000083182 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - |
| intron-3CDS | ENST00000537567 | ENST00000083182 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - |
| intron-3CDS | ENST00000588617 | ENST00000083182 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - |
| intron-intron | ENST00000537567 | ENST00000592995 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - |
| intron-intron | ENST00000588617 | ENST00000592995 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000262291 | VMP1 | chr17 | 57816308 | - | ENST00000083182 | APPBP2 | chr17 | 58577848 | - | 6766 | 724 | 253 | 2343 | 696 |
| ENST00000536180 | VMP1 | chr17 | 57816308 | - | ENST00000083182 | APPBP2 | chr17 | 58577848 | - | 6475 | 433 | 310 | 2052 | 580 |
| ENST00000545362 | VMP1 | chr17 | 57816308 | - | ENST00000083182 | APPBP2 | chr17 | 58577848 | - | 6509 | 467 | 41 | 2086 | 681 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000262291 | ENST00000083182 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - | 0.000268668 | 0.99973136 |
| ENST00000536180 | ENST00000083182 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - | 0.000401562 | 0.99959844 |
| ENST00000545362 | ENST00000083182 | VMP1 | chr17 | 57816308 | - | APPBP2 | chr17 | 58577848 | - | 0.000253232 | 0.99974674 |
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Fusion Genomic Features for VMP1-APPBP2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for VMP1-APPBP2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57816308/chr17:58577848) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | APPBP2 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. {ECO:0000269|PubMed:9843960}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 2_43 | 138 | 407.0 | Topological domain | Cytoplasmic |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 65_77 | 138 | 407.0 | Topological domain | Extracellular |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 99_109 | 138 | 407.0 | Topological domain | Cytoplasmic |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 110_130 | 138 | 407.0 | Transmembrane | Helical |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 44_64 | 138 | 407.0 | Transmembrane | Helical |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 78_98 | 138 | 407.0 | Transmembrane | Helical |
| Tgene | APPBP2 | chr17:57816308 | chr17:58577848 | ENST00000083182 | 0 | 13 | 120_153 | 46 | 586.0 | Repeat | Note=TPR 2 | |
| Tgene | APPBP2 | chr17:57816308 | chr17:58577848 | ENST00000083182 | 0 | 13 | 206_239 | 46 | 586.0 | Repeat | Note=TPR 3 | |
| Tgene | APPBP2 | chr17:57816308 | chr17:58577848 | ENST00000083182 | 0 | 13 | 288_321 | 46 | 586.0 | Repeat | Note=TPR 4 | |
| Tgene | APPBP2 | chr17:57816308 | chr17:58577848 | ENST00000083182 | 0 | 13 | 333_367 | 46 | 586.0 | Repeat | Note=TPR 5 | |
| Tgene | APPBP2 | chr17:57816308 | chr17:58577848 | ENST00000083182 | 0 | 13 | 429_462 | 46 | 586.0 | Repeat | Note=TPR 6 | |
| Tgene | APPBP2 | chr17:57816308 | chr17:58577848 | ENST00000083182 | 0 | 13 | 471_505 | 46 | 586.0 | Repeat | Note=TPR 7 | |
| Tgene | APPBP2 | chr17:57816308 | chr17:58577848 | ENST00000083182 | 0 | 13 | 50_83 | 46 | 586.0 | Repeat | Note=TPR 1 | |
| Tgene | APPBP2 | chr17:57816308 | chr17:58577848 | ENST00000083182 | 0 | 13 | 514_547 | 46 | 586.0 | Repeat | Note=TPR 8 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 173_316 | 138 | 407.0 | Region | VTT domain |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 131_250 | 138 | 407.0 | Topological domain | Extracellular |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 272_273 | 138 | 407.0 | Topological domain | Cytoplasmic |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 295_305 | 138 | 407.0 | Topological domain | Extracellular |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 327_363 | 138 | 407.0 | Topological domain | Cytoplasmic |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 385_406 | 138 | 407.0 | Topological domain | Extracellular |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 251_271 | 138 | 407.0 | Transmembrane | Helical |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 274_294 | 138 | 407.0 | Transmembrane | Helical |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 306_326 | 138 | 407.0 | Transmembrane | Helical |
| Hgene | VMP1 | chr17:57816308 | chr17:58577848 | ENST00000262291 | - | 5 | 12 | 364_384 | 138 | 407.0 | Transmembrane | Helical |
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Fusion Gene Sequence for VMP1-APPBP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >98193_98193_1_VMP1-APPBP2_VMP1_chr17_57816308_ENST00000262291_APPBP2_chr17_58577848_ENST00000083182_length(transcript)=6766nt_BP=724nt GACAAGTTCCGGATCAAGAATCACAAAGCGAGCAGTCATTCTTCCTCTTGCCACACCCACAGGGCCCGCACTAAGAGCCTAACTGAAATC CCGCGAGGATCAACCGAGCTCGCCGAAAGGAGGGAGGAACGTATCCCTTCTGGAGGCTGTCTCAGGGGGCAGAGGGACCGGACCGGAAGT GACGTGAGCGGGTTCCGGTTGTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGC CGGGGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAA GGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTG GAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTATGGCATCGTCAAAG CATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTATGTTGAAGGAGTGCATCAACAGTATGTGCAACGTATAGA GAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTA TCTGCTTTACCAACAGGGACGCTTATGTCAACTGGGCAGTGAATTTTGTGAATTGGAAGTTTTTGCTAAAGTACTGAGAGCTTTGGATAA AAGACATTTGCTTCATCATTGTTTTCAGGCTTTGATGGATCATGGTGTTAAAGTTGCTTCAGTCTTGGCCTACTCATTCAGTAGGCGGTG CTCTTATATAGCAGAATCAGATGCTGCAGTAAAGGAAAAAGCCATTCAGGTTGGCTTTGTTTTAGGTGGCTTTCTTTCAGATGCAGGCTG GTACAGTGATGCTGAGAAAGTTTTTCTGTCCTGCCTTCAGTTGTGTACTCTACACGATGAGATGCTTCATTGGTTTCGTGCAGTAGAATG TTGTGTGAGGTTGCTTCATGTGCGAAATGGAAACTGCAAATATCATTTGGGTGAAGAAACATTTAAATTAGCTCAGACATATATGGATAA ACTATCAAAACATGGCCAGCAAGCAAATAAAGCTGCACTCTATGGAGAACTGTGTGCACTCCTATTTGCAAAAAGTCACTATGATGAGGC ATACAAATGGTGCATCGAGGCAATGAAAGAAATTACAGCAGGCTTACCAGTGAAAGTTGTGGTGGATGTCTTAAGACAAGCTTCTAAGGC TTGTGTAGTAAAACGTGAATTTAAGAAGGCAGAACAGTTAATTAAACATGCAGTGTATTTGGCACGGGATCATTTTGGATCCAAACACCC AAAATATTCTGATACACTGCTAGATTATGGGTTCTACTTACTCAATGTAGATAATATCTGTCAGTCTGTTGCAATTTATCAGGCAGCCCT TGACATTAGACAGTCAGTGTTTGGTGGCAAAAATATCCACGTAGCAACAGCTCATGAAGATTTGGCCTACTCTTCTTATGTCCACCAGTA TAGCTCTGGGAAATTTGACAATGCACTATTTCATGCAGAAAGAGCTATTGGTATCATTACCCACATCCTACCTGAAGATCATCTTCTTTT GGCTTCTTCAAAGAGGGTGAAAGCACTTATTTTAGAGGAGATTGCAATTGATTGTCATAATAAGGAAACTGAACAGAGGCTGCTTCAAGA AGCTCATGATTTGCACCTGTCTTCACTCCAACTAGCTAAAAAAGCTTTTGGGGAATTTAATGTACAGACTGCAAAACACTATGGAAACCT TGGAAGACTTTATCAGTCAATGAGAAAATTTAAGGAAGCTGAAGAAATGCACATCAAAGCAATTCAGATTAAAGAACAACTTCTTGGTCA AGAAGATTATGAAGTAGCCCTTTCAGTGGGACATCTGGCTTCTTTATATAATTATGACATGAATCAGTATGAAAATGCTGAGAAACTTTA TTTGCGATCTATAGCAATTGGGAAGAAACTTTTTGGTGAGGGCTACAGTGGACTAGAATATGATTATCGAGGTCTCATTAAACTTTACAA CTCCATTGGAAATTACGAGAAAGTGTTTGAATATCACAATGTTCTGTCTAACTGGAACCGGTTGCGAGATCGGCAATATTCAGTGACAGA TGCTCTTGAAGATGTCAGCACCAGCCCCCAGTCCACTGAAGAAGTGGTGCAGTCCTTCCTGATTTCTCAGAATGTCGAGGGACCGAGCTG CTGAGGGAGGACCTCAGTTAACCAATTACCTTTTCCCGGATTCCAGGGAATTCATACTGTGAAATCAAAACCATGTTGTTTTGGGGGGCT GGAATTTGCATTGAAACACTGGTCCAGTCCATTGAAGACCCTATTTTGGGTGATCCCTATCTTGCAGAATGTCTGTAGGAATAAGCATAT ATTCAGTTATATTCAGCATGTACCGCATGTGTAAGTAGTCTGGCCCACATTTTCAACCTAGTAGAACAAACAACAGGAAATCTTTTTTTT GTTGTTTTTAAAAAATTCATTTTGCAGAAAGCCTGAAAGAAAAAAAATACCCCTAAATAAAACTATTTAAGAGTTTAAAAGAGTTGCATT CTTATTATGTAAGGATGATTTTAACAACTTTTTAATATGTAATTCTTCCATGTGGAGGTATTCAATACTGTAGTGTAAAGAAATTTTATG CGGAAAATCTTTATATGCAGTATAGAAAAGTTAACACAAGTACTAATAAAAGAGGGACATCCCGACTTACGTTTTTCTACCTTGCCCAGA TAAGTGGATACAACCACTCTATATTACAAGGAAAGGACTGTCAGATTCATCTGAACTGGACCAGTGTTGATCTGTAATGTAATAGAAAAT CTGATAGACCAGCACTTCTGACTTTTTTTTTTTTGGTACAACAATGCAAGATGCTCTGATAGCATTTGCTAACAGGACCAGGAGGATCTA AAAAGGACCAGCCTAATGTAGAAGGTGGTTACTTGGACCAGAGGCTTTAGATTATTATTTTAGATCCTACATATACTTTTATCAGTAGAA TGATTTCATTTAGATGTATAATGAAAAAGGATAATGCAAAAATTATGTAATAGATACCAAATTAGGGAAGTTTGGCAATTTCAATGGCAT ATTTTTAGTCAAGGTACACAGATGGCAGTGCCATAAGCAAGTCTATAAATATCGGCTGCAGCCATCCCCCTCATTTTAAATGTTGCCCTA ATAATCAATGCAGTTAACAAGTATATTGGCTGTGTGTCATGAAATAGTTCATGTTCAGATGGAAATGTTAGGTTACTGTATGGTTTATGG AGATTAATGAAAATGAATGCCCAAAAATAAGTCTTAGAAAATCCTCCATTTTTATGGTAAATAGTAATACAACTAGGTCATTTCATTTGA AATCTAGGAGTCAAATGGAAAGATCCCCTAATAATACACCTATTTCACTAACTTGTCTTTCTGTTTATTGGGTTTTGATTTGATTTTTTG TAAGCCAGTCAGGTTATTTAATGATGAGGTAATAATCAAATTTAAGAATTTGTGACATGTAGCAATTCAAGAAACAAAAAGGTATTTTGC TGTTACCTCAATTCTTACTGTAGTAGCCCATCTGATGCTTCTATAGTTAAGAATCTGGGTTCCCCCCCTATTTTCAGGGGTTCATGACTT GGCTGTTAAAGATGTTGCTCCTAGCTAATGCTTGGAGTAGTCTGTGGGTGAATGGATGTGTGTTGAATTTTAGTTTTCTTTTAACATGCA TGTTGGGTGAGAGGGGAAAAAAATCTAAGCTGTCTGCCACATTGAGTACAGAAAAGTTGTAGATTTCAAATTTTATTAATATTTTAAGCA CTTTTTTGAACTTCCCAACCTTGTTTGAAGCTGTTATTTGCAGTCCTATTAGTTTTGAGCCATTGCATTTAAGTTCCCTAGGAGGGGGTT GGTTGGGGGATGTACTGAAAGAGATGAAGCAAACCCACACCCTAAGATGGTAACTGTGTGATTTAGAAACCTGAGTTTACTCCTCAAATC GAATTATTTTCTTTTTAAATTTTGGAAAGAGTAAATTGACGTACTTGCAGTTTATGAAGCTGCCCCCCACCCCTCAGTTAATTGCAGTCT AATGTCAAGAGGCACTTCTTTATTAATTACCAAATAGTCTTTGTGACCAAGGACTAACATTTTTAAGTTACTCAGCTCTATCCTCATGGG CCTATATATTTAATACCTCCAAAGATATTTTCAGGATAGGCTTTGTATACTTTTATTGGTTATTTAGAATCCAGTGGTATGTTTGTGGTA TAGGAATGTCATGGTAAATTGTTTTTCAATAAATATTTTGAAACATGTTTCCATATGAAGTTTTTTTTTCAATCTGTATTTTTTGGTTTT GTGCACATACAGCATTTCCTAGGATAAAAATAAACAAATGACTTACAGCCTCATCCTCCCTAACTCCATTTGAACTCAACTTAGCTCACA CTCAGTGATAAAACAACATGGTATGTAGAAGCCTAGGATCACAGGGTGATAATGTCAATTGGCAGCCAGTTGTGTTTTTTTGAAACATCA TTATTGGCAGTTTCTCCTTATCACCACTGCTTTAATGTAGTTTTTTTGTAAATCCATATACTTTAATGCATACACTCTAGCTTAAGAAAA CATTGCCATTTTGGTTAGGGATATGACTTAATGTGCTATTATTTCTGGTTCTAATGAAGAATAATACCCTATGACTTTAAGTGTAAGATT CATCCTTTAAGTAGGGATGTTTAGGATAAGTTAGATGTGTGCCACTATGATTTATTGGGTTTCTTAAAAATCTTGAAGAAAATAATAAAA TTTATCTCACAATAAGTTAACTTGCGCAAACTTTTTACATATGGTGAGGTGCGTAAGGAAGCCCTGGCCAACTTAAAGATTTTTCTGGAG GTTCAGCAAAGTTATGTTAAATTAGGGGCCTTTGGTCTCATCCTTCTCTGACTCTTCTACCCAGTCTTTTCCTAAAGTTCGGTGCTACTC CAGTTGGGTGCATCAGGGAGCTCCGTCAGCACTCGCATGTGTCGCTCAGGTGGCCACTCATGCCTGCATTCCATTTAATAGAGTCAATTG GAATTTTTAGAGCATAATCTTTATGGATCCTCAAAGCTGACTTTGCCAAAGGGATTGAGACCCTTACTACCATCAAATCTCTGTCTCTGC TTGGTTAAAAATTGGCTCACTATTGCTTTGTAGTAACCCCTGCCCAGGTATTTTTTCACTTGTGAAAATAATTTGAGAAAGACCTTTGTT CCTAGCCTGTTGGGAAAAGTTTATAATTTTATGAAAATTAAGTACAGAGGCTGCGATCTTAGAAATAATGAAGGTGCCATTTGGCTGCTC CTTAATAGTGCAGACAGAAAACTGCAGTGAACACATGCCAAAACATGATTGAAGCCTTTGGCTGAAACTTTATACATAGAAATAATGATT TGCTCATAACAGGTATCATTAACTGCCACTTTTTATGTTTTCCCTAGAATTTGTAGCCTTGCTGCTTGCTTTTCTTCTGGGTGGCAAAGT TACTACTGGAAAAACACTATAAGTACAAAGTTTTTGGGGTTTTATCTTTGCTTTAGAAGTGGATGTGTACTTCACCTCTTGGCTGTGGAG GAACTTAGTTGCCAGGAAATTTTTTTTTTTTTTTTCAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGGAGGGCAATGGCACCGTCTTGG CTCACTGCAACCTCCGCCTCCCGGGTTCCAGCGATTCTCCTGCCTCAGCCTTCCGAGTAGCTGGGATTACAGGCTCCTGCCACCACGCCT GGCTAGGAAATTTTTTGTTGTTAATATGACATTTGGATTAATCTCCAGCTTCAACAGTACTTCTTTTGTCCATAAATCTCAGGAATGTTT TAGGCAGAAAACTGGTTTTACCCTGTTGATAATCAGAAGGAGTGTGCTTTAGGATTTATTGCATAATACTATTCTTTAATTGCAATCCTA GGTATCTATAGCATGAGTGGCCTTAGTGAGTTTGTTGAAGTGCACATGTTTTTCAAGAGTAAAATTTAAGATTAAAAATATATCCTATAT ATAGATATCTAGAAAACTTGGTTTGTGGTGCACAGTTAAGTGTTGGATCACTAAATAACCATTGCAGGTACCGTTTGTGTAACATTACTC ATTTCTGTATATTCCTTTTATGGGAAGATATTTTGCCATGGTAACTAAAACTTTTCAGTTCTACTTTTATGATGTGAATGAATGCTACGT TTTATTAAATATTACCAGGTCAGTACTATTTTTATACTTTATTAAGCAACAGGGGATTTTAGTTTAATAGGCTCAAAATAAAAAGTTCTT AATGGAACAGTTAAAAACAAAACACTAACAATCTTTACGTGAAAATCCCCACTAATAGTGCCACAATAATTTCTATAGAAATATCTAAGG TCATTAAATAGATTTTTGAAGACGGTTCTTCATTGTGTCAGGATGACCTTTCATATCATTCTCACCAACTTGTAGTGCCCACCGTTATTT GTAACTATTAAACCATACTAAGTATGTTTGTAACCAGCATTGTGATATATTCTGTACTTGTATTGCTAAAAATGAATTATTGACCTAATA >98193_98193_1_VMP1-APPBP2_VMP1_chr17_57816308_ENST00000262291_APPBP2_chr17_58577848_ENST00000083182_length(amino acids)=696AA_BP=157 MRSGAAGVGAAPQELLIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSK LWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLLYQQGRLCQLGSEFCELEVFAKV LRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHW FRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVL RQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYS SYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTA KHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRG -------------------------------------------------------------- >98193_98193_2_VMP1-APPBP2_VMP1_chr17_57816308_ENST00000536180_APPBP2_chr17_58577848_ENST00000083182_length(transcript)=6475nt_BP=433nt GTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGCCGGGGTCGGAGCGGCTCCTC AAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGAACATCATAATGGAAATT TCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTGGAGACAGCCGCTCATTACCT TGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAATATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGC CTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTATCTGCTTTACCAACAGGGACG CTTATGTCAACTGGGCAGTGAATTTTGTGAATTGGAAGTTTTTGCTAAAGTACTGAGAGCTTTGGATAAAAGACATTTGCTTCATCATTG TTTTCAGGCTTTGATGGATCATGGTGTTAAAGTTGCTTCAGTCTTGGCCTACTCATTCAGTAGGCGGTGCTCTTATATAGCAGAATCAGA TGCTGCAGTAAAGGAAAAAGCCATTCAGGTTGGCTTTGTTTTAGGTGGCTTTCTTTCAGATGCAGGCTGGTACAGTGATGCTGAGAAAGT TTTTCTGTCCTGCCTTCAGTTGTGTACTCTACACGATGAGATGCTTCATTGGTTTCGTGCAGTAGAATGTTGTGTGAGGTTGCTTCATGT GCGAAATGGAAACTGCAAATATCATTTGGGTGAAGAAACATTTAAATTAGCTCAGACATATATGGATAAACTATCAAAACATGGCCAGCA AGCAAATAAAGCTGCACTCTATGGAGAACTGTGTGCACTCCTATTTGCAAAAAGTCACTATGATGAGGCATACAAATGGTGCATCGAGGC AATGAAAGAAATTACAGCAGGCTTACCAGTGAAAGTTGTGGTGGATGTCTTAAGACAAGCTTCTAAGGCTTGTGTAGTAAAACGTGAATT TAAGAAGGCAGAACAGTTAATTAAACATGCAGTGTATTTGGCACGGGATCATTTTGGATCCAAACACCCAAAATATTCTGATACACTGCT AGATTATGGGTTCTACTTACTCAATGTAGATAATATCTGTCAGTCTGTTGCAATTTATCAGGCAGCCCTTGACATTAGACAGTCAGTGTT TGGTGGCAAAAATATCCACGTAGCAACAGCTCATGAAGATTTGGCCTACTCTTCTTATGTCCACCAGTATAGCTCTGGGAAATTTGACAA TGCACTATTTCATGCAGAAAGAGCTATTGGTATCATTACCCACATCCTACCTGAAGATCATCTTCTTTTGGCTTCTTCAAAGAGGGTGAA AGCACTTATTTTAGAGGAGATTGCAATTGATTGTCATAATAAGGAAACTGAACAGAGGCTGCTTCAAGAAGCTCATGATTTGCACCTGTC TTCACTCCAACTAGCTAAAAAAGCTTTTGGGGAATTTAATGTACAGACTGCAAAACACTATGGAAACCTTGGAAGACTTTATCAGTCAAT GAGAAAATTTAAGGAAGCTGAAGAAATGCACATCAAAGCAATTCAGATTAAAGAACAACTTCTTGGTCAAGAAGATTATGAAGTAGCCCT TTCAGTGGGACATCTGGCTTCTTTATATAATTATGACATGAATCAGTATGAAAATGCTGAGAAACTTTATTTGCGATCTATAGCAATTGG GAAGAAACTTTTTGGTGAGGGCTACAGTGGACTAGAATATGATTATCGAGGTCTCATTAAACTTTACAACTCCATTGGAAATTACGAGAA AGTGTTTGAATATCACAATGTTCTGTCTAACTGGAACCGGTTGCGAGATCGGCAATATTCAGTGACAGATGCTCTTGAAGATGTCAGCAC CAGCCCCCAGTCCACTGAAGAAGTGGTGCAGTCCTTCCTGATTTCTCAGAATGTCGAGGGACCGAGCTGCTGAGGGAGGACCTCAGTTAA CCAATTACCTTTTCCCGGATTCCAGGGAATTCATACTGTGAAATCAAAACCATGTTGTTTTGGGGGGCTGGAATTTGCATTGAAACACTG GTCCAGTCCATTGAAGACCCTATTTTGGGTGATCCCTATCTTGCAGAATGTCTGTAGGAATAAGCATATATTCAGTTATATTCAGCATGT ACCGCATGTGTAAGTAGTCTGGCCCACATTTTCAACCTAGTAGAACAAACAACAGGAAATCTTTTTTTTGTTGTTTTTAAAAAATTCATT TTGCAGAAAGCCTGAAAGAAAAAAAATACCCCTAAATAAAACTATTTAAGAGTTTAAAAGAGTTGCATTCTTATTATGTAAGGATGATTT TAACAACTTTTTAATATGTAATTCTTCCATGTGGAGGTATTCAATACTGTAGTGTAAAGAAATTTTATGCGGAAAATCTTTATATGCAGT ATAGAAAAGTTAACACAAGTACTAATAAAAGAGGGACATCCCGACTTACGTTTTTCTACCTTGCCCAGATAAGTGGATACAACCACTCTA TATTACAAGGAAAGGACTGTCAGATTCATCTGAACTGGACCAGTGTTGATCTGTAATGTAATAGAAAATCTGATAGACCAGCACTTCTGA CTTTTTTTTTTTTGGTACAACAATGCAAGATGCTCTGATAGCATTTGCTAACAGGACCAGGAGGATCTAAAAAGGACCAGCCTAATGTAG AAGGTGGTTACTTGGACCAGAGGCTTTAGATTATTATTTTAGATCCTACATATACTTTTATCAGTAGAATGATTTCATTTAGATGTATAA TGAAAAAGGATAATGCAAAAATTATGTAATAGATACCAAATTAGGGAAGTTTGGCAATTTCAATGGCATATTTTTAGTCAAGGTACACAG ATGGCAGTGCCATAAGCAAGTCTATAAATATCGGCTGCAGCCATCCCCCTCATTTTAAATGTTGCCCTAATAATCAATGCAGTTAACAAG TATATTGGCTGTGTGTCATGAAATAGTTCATGTTCAGATGGAAATGTTAGGTTACTGTATGGTTTATGGAGATTAATGAAAATGAATGCC CAAAAATAAGTCTTAGAAAATCCTCCATTTTTATGGTAAATAGTAATACAACTAGGTCATTTCATTTGAAATCTAGGAGTCAAATGGAAA GATCCCCTAATAATACACCTATTTCACTAACTTGTCTTTCTGTTTATTGGGTTTTGATTTGATTTTTTGTAAGCCAGTCAGGTTATTTAA TGATGAGGTAATAATCAAATTTAAGAATTTGTGACATGTAGCAATTCAAGAAACAAAAAGGTATTTTGCTGTTACCTCAATTCTTACTGT AGTAGCCCATCTGATGCTTCTATAGTTAAGAATCTGGGTTCCCCCCCTATTTTCAGGGGTTCATGACTTGGCTGTTAAAGATGTTGCTCC TAGCTAATGCTTGGAGTAGTCTGTGGGTGAATGGATGTGTGTTGAATTTTAGTTTTCTTTTAACATGCATGTTGGGTGAGAGGGGAAAAA AATCTAAGCTGTCTGCCACATTGAGTACAGAAAAGTTGTAGATTTCAAATTTTATTAATATTTTAAGCACTTTTTTGAACTTCCCAACCT TGTTTGAAGCTGTTATTTGCAGTCCTATTAGTTTTGAGCCATTGCATTTAAGTTCCCTAGGAGGGGGTTGGTTGGGGGATGTACTGAAAG AGATGAAGCAAACCCACACCCTAAGATGGTAACTGTGTGATTTAGAAACCTGAGTTTACTCCTCAAATCGAATTATTTTCTTTTTAAATT TTGGAAAGAGTAAATTGACGTACTTGCAGTTTATGAAGCTGCCCCCCACCCCTCAGTTAATTGCAGTCTAATGTCAAGAGGCACTTCTTT ATTAATTACCAAATAGTCTTTGTGACCAAGGACTAACATTTTTAAGTTACTCAGCTCTATCCTCATGGGCCTATATATTTAATACCTCCA AAGATATTTTCAGGATAGGCTTTGTATACTTTTATTGGTTATTTAGAATCCAGTGGTATGTTTGTGGTATAGGAATGTCATGGTAAATTG TTTTTCAATAAATATTTTGAAACATGTTTCCATATGAAGTTTTTTTTTCAATCTGTATTTTTTGGTTTTGTGCACATACAGCATTTCCTA GGATAAAAATAAACAAATGACTTACAGCCTCATCCTCCCTAACTCCATTTGAACTCAACTTAGCTCACACTCAGTGATAAAACAACATGG TATGTAGAAGCCTAGGATCACAGGGTGATAATGTCAATTGGCAGCCAGTTGTGTTTTTTTGAAACATCATTATTGGCAGTTTCTCCTTAT CACCACTGCTTTAATGTAGTTTTTTTGTAAATCCATATACTTTAATGCATACACTCTAGCTTAAGAAAACATTGCCATTTTGGTTAGGGA TATGACTTAATGTGCTATTATTTCTGGTTCTAATGAAGAATAATACCCTATGACTTTAAGTGTAAGATTCATCCTTTAAGTAGGGATGTT TAGGATAAGTTAGATGTGTGCCACTATGATTTATTGGGTTTCTTAAAAATCTTGAAGAAAATAATAAAATTTATCTCACAATAAGTTAAC TTGCGCAAACTTTTTACATATGGTGAGGTGCGTAAGGAAGCCCTGGCCAACTTAAAGATTTTTCTGGAGGTTCAGCAAAGTTATGTTAAA TTAGGGGCCTTTGGTCTCATCCTTCTCTGACTCTTCTACCCAGTCTTTTCCTAAAGTTCGGTGCTACTCCAGTTGGGTGCATCAGGGAGC TCCGTCAGCACTCGCATGTGTCGCTCAGGTGGCCACTCATGCCTGCATTCCATTTAATAGAGTCAATTGGAATTTTTAGAGCATAATCTT TATGGATCCTCAAAGCTGACTTTGCCAAAGGGATTGAGACCCTTACTACCATCAAATCTCTGTCTCTGCTTGGTTAAAAATTGGCTCACT ATTGCTTTGTAGTAACCCCTGCCCAGGTATTTTTTCACTTGTGAAAATAATTTGAGAAAGACCTTTGTTCCTAGCCTGTTGGGAAAAGTT TATAATTTTATGAAAATTAAGTACAGAGGCTGCGATCTTAGAAATAATGAAGGTGCCATTTGGCTGCTCCTTAATAGTGCAGACAGAAAA CTGCAGTGAACACATGCCAAAACATGATTGAAGCCTTTGGCTGAAACTTTATACATAGAAATAATGATTTGCTCATAACAGGTATCATTA ACTGCCACTTTTTATGTTTTCCCTAGAATTTGTAGCCTTGCTGCTTGCTTTTCTTCTGGGTGGCAAAGTTACTACTGGAAAAACACTATA AGTACAAAGTTTTTGGGGTTTTATCTTTGCTTTAGAAGTGGATGTGTACTTCACCTCTTGGCTGTGGAGGAACTTAGTTGCCAGGAAATT TTTTTTTTTTTTTTCAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGGAGGGCAATGGCACCGTCTTGGCTCACTGCAACCTCCGCCTCC CGGGTTCCAGCGATTCTCCTGCCTCAGCCTTCCGAGTAGCTGGGATTACAGGCTCCTGCCACCACGCCTGGCTAGGAAATTTTTTGTTGT TAATATGACATTTGGATTAATCTCCAGCTTCAACAGTACTTCTTTTGTCCATAAATCTCAGGAATGTTTTAGGCAGAAAACTGGTTTTAC CCTGTTGATAATCAGAAGGAGTGTGCTTTAGGATTTATTGCATAATACTATTCTTTAATTGCAATCCTAGGTATCTATAGCATGAGTGGC CTTAGTGAGTTTGTTGAAGTGCACATGTTTTTCAAGAGTAAAATTTAAGATTAAAAATATATCCTATATATAGATATCTAGAAAACTTGG TTTGTGGTGCACAGTTAAGTGTTGGATCACTAAATAACCATTGCAGGTACCGTTTGTGTAACATTACTCATTTCTGTATATTCCTTTTAT GGGAAGATATTTTGCCATGGTAACTAAAACTTTTCAGTTCTACTTTTATGATGTGAATGAATGCTACGTTTTATTAAATATTACCAGGTC AGTACTATTTTTATACTTTATTAAGCAACAGGGGATTTTAGTTTAATAGGCTCAAAATAAAAAGTTCTTAATGGAACAGTTAAAAACAAA ACACTAACAATCTTTACGTGAAAATCCCCACTAATAGTGCCACAATAATTTCTATAGAAATATCTAAGGTCATTAAATAGATTTTTGAAG ACGGTTCTTCATTGTGTCAGGATGACCTTTCATATCATTCTCACCAACTTGTAGTGCCCACCGTTATTTGTAACTATTAAACCATACTAA >98193_98193_2_VMP1-APPBP2_VMP1_chr17_57816308_ENST00000536180_APPBP2_chr17_58577848_ENST00000083182_length(amino acids)=580AA_BP=41 MDLKYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVAS VLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEET FKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYL ARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIIT HILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKA IQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNR -------------------------------------------------------------- >98193_98193_3_VMP1-APPBP2_VMP1_chr17_57816308_ENST00000545362_APPBP2_chr17_58577848_ENST00000083182_length(transcript)=6509nt_BP=467nt GATCCGGAGCAGCCGGGGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTG TAGCAATGAACAAGGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGA ATATTGTCCTGTGGAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTAT GGCATCGTCAAAGCATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTATGTTGAAGGAGTGCATCAACAGTATG TGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACA CCTTTCTGCTTTATCTGCTTTACCAACAGGGACGCTTATGTCAACTGGGCAGTGAATTTTGTGAATTGGAAGTTTTTGCTAAAGTACTGA GAGCTTTGGATAAAAGACATTTGCTTCATCATTGTTTTCAGGCTTTGATGGATCATGGTGTTAAAGTTGCTTCAGTCTTGGCCTACTCAT TCAGTAGGCGGTGCTCTTATATAGCAGAATCAGATGCTGCAGTAAAGGAAAAAGCCATTCAGGTTGGCTTTGTTTTAGGTGGCTTTCTTT CAGATGCAGGCTGGTACAGTGATGCTGAGAAAGTTTTTCTGTCCTGCCTTCAGTTGTGTACTCTACACGATGAGATGCTTCATTGGTTTC GTGCAGTAGAATGTTGTGTGAGGTTGCTTCATGTGCGAAATGGAAACTGCAAATATCATTTGGGTGAAGAAACATTTAAATTAGCTCAGA CATATATGGATAAACTATCAAAACATGGCCAGCAAGCAAATAAAGCTGCACTCTATGGAGAACTGTGTGCACTCCTATTTGCAAAAAGTC ACTATGATGAGGCATACAAATGGTGCATCGAGGCAATGAAAGAAATTACAGCAGGCTTACCAGTGAAAGTTGTGGTGGATGTCTTAAGAC AAGCTTCTAAGGCTTGTGTAGTAAAACGTGAATTTAAGAAGGCAGAACAGTTAATTAAACATGCAGTGTATTTGGCACGGGATCATTTTG GATCCAAACACCCAAAATATTCTGATACACTGCTAGATTATGGGTTCTACTTACTCAATGTAGATAATATCTGTCAGTCTGTTGCAATTT ATCAGGCAGCCCTTGACATTAGACAGTCAGTGTTTGGTGGCAAAAATATCCACGTAGCAACAGCTCATGAAGATTTGGCCTACTCTTCTT ATGTCCACCAGTATAGCTCTGGGAAATTTGACAATGCACTATTTCATGCAGAAAGAGCTATTGGTATCATTACCCACATCCTACCTGAAG ATCATCTTCTTTTGGCTTCTTCAAAGAGGGTGAAAGCACTTATTTTAGAGGAGATTGCAATTGATTGTCATAATAAGGAAACTGAACAGA GGCTGCTTCAAGAAGCTCATGATTTGCACCTGTCTTCACTCCAACTAGCTAAAAAAGCTTTTGGGGAATTTAATGTACAGACTGCAAAAC ACTATGGAAACCTTGGAAGACTTTATCAGTCAATGAGAAAATTTAAGGAAGCTGAAGAAATGCACATCAAAGCAATTCAGATTAAAGAAC AACTTCTTGGTCAAGAAGATTATGAAGTAGCCCTTTCAGTGGGACATCTGGCTTCTTTATATAATTATGACATGAATCAGTATGAAAATG CTGAGAAACTTTATTTGCGATCTATAGCAATTGGGAAGAAACTTTTTGGTGAGGGCTACAGTGGACTAGAATATGATTATCGAGGTCTCA TTAAACTTTACAACTCCATTGGAAATTACGAGAAAGTGTTTGAATATCACAATGTTCTGTCTAACTGGAACCGGTTGCGAGATCGGCAAT ATTCAGTGACAGATGCTCTTGAAGATGTCAGCACCAGCCCCCAGTCCACTGAAGAAGTGGTGCAGTCCTTCCTGATTTCTCAGAATGTCG AGGGACCGAGCTGCTGAGGGAGGACCTCAGTTAACCAATTACCTTTTCCCGGATTCCAGGGAATTCATACTGTGAAATCAAAACCATGTT GTTTTGGGGGGCTGGAATTTGCATTGAAACACTGGTCCAGTCCATTGAAGACCCTATTTTGGGTGATCCCTATCTTGCAGAATGTCTGTA GGAATAAGCATATATTCAGTTATATTCAGCATGTACCGCATGTGTAAGTAGTCTGGCCCACATTTTCAACCTAGTAGAACAAACAACAGG AAATCTTTTTTTTGTTGTTTTTAAAAAATTCATTTTGCAGAAAGCCTGAAAGAAAAAAAATACCCCTAAATAAAACTATTTAAGAGTTTA AAAGAGTTGCATTCTTATTATGTAAGGATGATTTTAACAACTTTTTAATATGTAATTCTTCCATGTGGAGGTATTCAATACTGTAGTGTA AAGAAATTTTATGCGGAAAATCTTTATATGCAGTATAGAAAAGTTAACACAAGTACTAATAAAAGAGGGACATCCCGACTTACGTTTTTC TACCTTGCCCAGATAAGTGGATACAACCACTCTATATTACAAGGAAAGGACTGTCAGATTCATCTGAACTGGACCAGTGTTGATCTGTAA TGTAATAGAAAATCTGATAGACCAGCACTTCTGACTTTTTTTTTTTTGGTACAACAATGCAAGATGCTCTGATAGCATTTGCTAACAGGA CCAGGAGGATCTAAAAAGGACCAGCCTAATGTAGAAGGTGGTTACTTGGACCAGAGGCTTTAGATTATTATTTTAGATCCTACATATACT TTTATCAGTAGAATGATTTCATTTAGATGTATAATGAAAAAGGATAATGCAAAAATTATGTAATAGATACCAAATTAGGGAAGTTTGGCA ATTTCAATGGCATATTTTTAGTCAAGGTACACAGATGGCAGTGCCATAAGCAAGTCTATAAATATCGGCTGCAGCCATCCCCCTCATTTT AAATGTTGCCCTAATAATCAATGCAGTTAACAAGTATATTGGCTGTGTGTCATGAAATAGTTCATGTTCAGATGGAAATGTTAGGTTACT GTATGGTTTATGGAGATTAATGAAAATGAATGCCCAAAAATAAGTCTTAGAAAATCCTCCATTTTTATGGTAAATAGTAATACAACTAGG TCATTTCATTTGAAATCTAGGAGTCAAATGGAAAGATCCCCTAATAATACACCTATTTCACTAACTTGTCTTTCTGTTTATTGGGTTTTG ATTTGATTTTTTGTAAGCCAGTCAGGTTATTTAATGATGAGGTAATAATCAAATTTAAGAATTTGTGACATGTAGCAATTCAAGAAACAA AAAGGTATTTTGCTGTTACCTCAATTCTTACTGTAGTAGCCCATCTGATGCTTCTATAGTTAAGAATCTGGGTTCCCCCCCTATTTTCAG GGGTTCATGACTTGGCTGTTAAAGATGTTGCTCCTAGCTAATGCTTGGAGTAGTCTGTGGGTGAATGGATGTGTGTTGAATTTTAGTTTT CTTTTAACATGCATGTTGGGTGAGAGGGGAAAAAAATCTAAGCTGTCTGCCACATTGAGTACAGAAAAGTTGTAGATTTCAAATTTTATT AATATTTTAAGCACTTTTTTGAACTTCCCAACCTTGTTTGAAGCTGTTATTTGCAGTCCTATTAGTTTTGAGCCATTGCATTTAAGTTCC CTAGGAGGGGGTTGGTTGGGGGATGTACTGAAAGAGATGAAGCAAACCCACACCCTAAGATGGTAACTGTGTGATTTAGAAACCTGAGTT TACTCCTCAAATCGAATTATTTTCTTTTTAAATTTTGGAAAGAGTAAATTGACGTACTTGCAGTTTATGAAGCTGCCCCCCACCCCTCAG TTAATTGCAGTCTAATGTCAAGAGGCACTTCTTTATTAATTACCAAATAGTCTTTGTGACCAAGGACTAACATTTTTAAGTTACTCAGCT CTATCCTCATGGGCCTATATATTTAATACCTCCAAAGATATTTTCAGGATAGGCTTTGTATACTTTTATTGGTTATTTAGAATCCAGTGG TATGTTTGTGGTATAGGAATGTCATGGTAAATTGTTTTTCAATAAATATTTTGAAACATGTTTCCATATGAAGTTTTTTTTTCAATCTGT ATTTTTTGGTTTTGTGCACATACAGCATTTCCTAGGATAAAAATAAACAAATGACTTACAGCCTCATCCTCCCTAACTCCATTTGAACTC AACTTAGCTCACACTCAGTGATAAAACAACATGGTATGTAGAAGCCTAGGATCACAGGGTGATAATGTCAATTGGCAGCCAGTTGTGTTT TTTTGAAACATCATTATTGGCAGTTTCTCCTTATCACCACTGCTTTAATGTAGTTTTTTTGTAAATCCATATACTTTAATGCATACACTC TAGCTTAAGAAAACATTGCCATTTTGGTTAGGGATATGACTTAATGTGCTATTATTTCTGGTTCTAATGAAGAATAATACCCTATGACTT TAAGTGTAAGATTCATCCTTTAAGTAGGGATGTTTAGGATAAGTTAGATGTGTGCCACTATGATTTATTGGGTTTCTTAAAAATCTTGAA GAAAATAATAAAATTTATCTCACAATAAGTTAACTTGCGCAAACTTTTTACATATGGTGAGGTGCGTAAGGAAGCCCTGGCCAACTTAAA GATTTTTCTGGAGGTTCAGCAAAGTTATGTTAAATTAGGGGCCTTTGGTCTCATCCTTCTCTGACTCTTCTACCCAGTCTTTTCCTAAAG TTCGGTGCTACTCCAGTTGGGTGCATCAGGGAGCTCCGTCAGCACTCGCATGTGTCGCTCAGGTGGCCACTCATGCCTGCATTCCATTTA ATAGAGTCAATTGGAATTTTTAGAGCATAATCTTTATGGATCCTCAAAGCTGACTTTGCCAAAGGGATTGAGACCCTTACTACCATCAAA TCTCTGTCTCTGCTTGGTTAAAAATTGGCTCACTATTGCTTTGTAGTAACCCCTGCCCAGGTATTTTTTCACTTGTGAAAATAATTTGAG AAAGACCTTTGTTCCTAGCCTGTTGGGAAAAGTTTATAATTTTATGAAAATTAAGTACAGAGGCTGCGATCTTAGAAATAATGAAGGTGC CATTTGGCTGCTCCTTAATAGTGCAGACAGAAAACTGCAGTGAACACATGCCAAAACATGATTGAAGCCTTTGGCTGAAACTTTATACAT AGAAATAATGATTTGCTCATAACAGGTATCATTAACTGCCACTTTTTATGTTTTCCCTAGAATTTGTAGCCTTGCTGCTTGCTTTTCTTC TGGGTGGCAAAGTTACTACTGGAAAAACACTATAAGTACAAAGTTTTTGGGGTTTTATCTTTGCTTTAGAAGTGGATGTGTACTTCACCT CTTGGCTGTGGAGGAACTTAGTTGCCAGGAAATTTTTTTTTTTTTTTTCAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGGAGGGCAAT GGCACCGTCTTGGCTCACTGCAACCTCCGCCTCCCGGGTTCCAGCGATTCTCCTGCCTCAGCCTTCCGAGTAGCTGGGATTACAGGCTCC TGCCACCACGCCTGGCTAGGAAATTTTTTGTTGTTAATATGACATTTGGATTAATCTCCAGCTTCAACAGTACTTCTTTTGTCCATAAAT CTCAGGAATGTTTTAGGCAGAAAACTGGTTTTACCCTGTTGATAATCAGAAGGAGTGTGCTTTAGGATTTATTGCATAATACTATTCTTT AATTGCAATCCTAGGTATCTATAGCATGAGTGGCCTTAGTGAGTTTGTTGAAGTGCACATGTTTTTCAAGAGTAAAATTTAAGATTAAAA ATATATCCTATATATAGATATCTAGAAAACTTGGTTTGTGGTGCACAGTTAAGTGTTGGATCACTAAATAACCATTGCAGGTACCGTTTG TGTAACATTACTCATTTCTGTATATTCCTTTTATGGGAAGATATTTTGCCATGGTAACTAAAACTTTTCAGTTCTACTTTTATGATGTGA ATGAATGCTACGTTTTATTAAATATTACCAGGTCAGTACTATTTTTATACTTTATTAAGCAACAGGGGATTTTAGTTTAATAGGCTCAAA ATAAAAAGTTCTTAATGGAACAGTTAAAAACAAAACACTAACAATCTTTACGTGAAAATCCCCACTAATAGTGCCACAATAATTTCTATA GAAATATCTAAGGTCATTAAATAGATTTTTGAAGACGGTTCTTCATTGTGTCAGGATGACCTTTCATATCATTCTCACCAACTTGTAGTG CCCACCGTTATTTGTAACTATTAAACCATACTAAGTATGTTTGTAACCAGCATTGTGATATATTCTGTACTTGTATTGCTAAAAATGAAT >98193_98193_3_VMP1-APPBP2_VMP1_chr17_57816308_ENST00000545362_APPBP2_chr17_58577848_ENST00000083182_length(amino acids)=681AA_BP=142 MIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLL AVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQ ALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRN GNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKK AEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNAL FHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRK FKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEKVF -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for VMP1-APPBP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for VMP1-APPBP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for VMP1-APPBP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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