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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VMP1-CLTC (FusionGDB2 ID:98198)

Fusion Gene Summary for VMP1-CLTC

check button Fusion gene summary
Fusion gene informationFusion gene name: VMP1-CLTC
Fusion gene ID: 98198
HgeneTgene
Gene symbol

VMP1

CLTC

Gene ID

81671

1213

Gene namevacuole membrane protein 1clathrin heavy chain
SynonymsEPG3|TANGO5|TMEM49CHC|CHC17|CLH-17|CLTCL2|Hc|MRD56
Cytomap

17q23.1

17q23.1

Type of geneprotein-codingprotein-coding
Descriptionvacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homologclathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2
Modification date2020032720200313
UniProtAcc.

P53675

Ensembl transtripts involved in fusion geneENST00000262291, ENST00000536180, 
ENST00000545362, ENST00000539763, 
ENST00000537567, ENST00000588617, 
ENST00000579815, ENST00000269122, 
ENST00000393043, ENST00000579456, 
Fusion gene scores* DoF score34 X 17 X 12=693618 X 18 X 8=2592
# samples 3822
** MAII scorelog2(38/6936*10)=-4.19003257489089
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2592*10)=-3.55849028935997
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VMP1 [Title/Abstract] AND CLTC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLTC(57733388)-VMP1(57915656), # samples:9
VMP1(57816308)-CLTC(57721637), # samples:2
Anticipated loss of major functional domain due to fusion event.CLTC-VMP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CLTC-VMP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CLTC-VMP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCLTC

GO:1900126

negative regulation of hyaluronan biosynthetic process

24251095


check buttonFusion gene breakpoints across VMP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLTC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1NA-01AVMP1chr17

57816308

-CLTCchr17

57721637

+
ChimerDB4BRCATCGA-E9-A1NA-01AVMP1chr17

57816308

+CLTCchr17

57721637

+
ChimerDB4BRCATCGA-E9-A1NAVMP1chr17

57816308

+CLTCchr17

57721636

+
ChimerDB4OVTCGA-30-1861-01AVMP1chr17

57785109

+CLTCchr17

57771089

+
ChimerDB4OVTCGA-30-1861VMP1chr17

57785109

+CLTCchr17

57771088

+


Top

Fusion Gene ORF analysis for VMP1-CLTC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262291ENST00000579815VMP1chr17

57816308

+CLTCchr17

57721637

+
5CDS-intronENST00000262291ENST00000579815VMP1chr17

57816308

+CLTCchr17

57721636

+
5CDS-intronENST00000536180ENST00000579815VMP1chr17

57816308

+CLTCchr17

57721637

+
5CDS-intronENST00000536180ENST00000579815VMP1chr17

57816308

+CLTCchr17

57721636

+
5CDS-intronENST00000545362ENST00000579815VMP1chr17

57816308

+CLTCchr17

57721637

+
5CDS-intronENST00000545362ENST00000579815VMP1chr17

57816308

+CLTCchr17

57721636

+
5UTR-3CDSENST00000539763ENST00000269122VMP1chr17

57816308

+CLTCchr17

57721637

+
5UTR-3CDSENST00000539763ENST00000269122VMP1chr17

57816308

+CLTCchr17

57721636

+
5UTR-3CDSENST00000539763ENST00000393043VMP1chr17

57816308

+CLTCchr17

57721637

+
5UTR-3CDSENST00000539763ENST00000393043VMP1chr17

57816308

+CLTCchr17

57721636

+
5UTR-3CDSENST00000539763ENST00000579456VMP1chr17

57816308

+CLTCchr17

57721637

+
5UTR-3CDSENST00000539763ENST00000579456VMP1chr17

57816308

+CLTCchr17

57721636

+
5UTR-intronENST00000262291ENST00000269122VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000262291ENST00000269122VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000262291ENST00000393043VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000262291ENST00000393043VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000262291ENST00000579456VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000262291ENST00000579456VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000262291ENST00000579815VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000262291ENST00000579815VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000536180ENST00000269122VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000536180ENST00000269122VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000536180ENST00000393043VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000536180ENST00000393043VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000536180ENST00000579456VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000536180ENST00000579456VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000536180ENST00000579815VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000536180ENST00000579815VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000537567ENST00000269122VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000537567ENST00000269122VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000537567ENST00000393043VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000537567ENST00000393043VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000537567ENST00000579456VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000537567ENST00000579456VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000537567ENST00000579815VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000537567ENST00000579815VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000539763ENST00000269122VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000539763ENST00000269122VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000539763ENST00000393043VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000539763ENST00000393043VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000539763ENST00000579456VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000539763ENST00000579456VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000539763ENST00000579815VMP1chr17

57816308

+CLTCchr17

57721637

+
5UTR-intronENST00000539763ENST00000579815VMP1chr17

57816308

+CLTCchr17

57721636

+
5UTR-intronENST00000539763ENST00000579815VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000539763ENST00000579815VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000545362ENST00000269122VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000545362ENST00000269122VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000545362ENST00000393043VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000545362ENST00000393043VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000545362ENST00000579456VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000545362ENST00000579456VMP1chr17

57785109

+CLTCchr17

57771088

+
5UTR-intronENST00000545362ENST00000579815VMP1chr17

57785109

+CLTCchr17

57771089

+
5UTR-intronENST00000545362ENST00000579815VMP1chr17

57785109

+CLTCchr17

57771088

+
In-frameENST00000262291ENST00000269122VMP1chr17

57816308

+CLTCchr17

57721637

+
In-frameENST00000262291ENST00000269122VMP1chr17

57816308

+CLTCchr17

57721636

+
In-frameENST00000262291ENST00000393043VMP1chr17

57816308

+CLTCchr17

57721637

+
In-frameENST00000262291ENST00000393043VMP1chr17

57816308

+CLTCchr17

57721636

+
In-frameENST00000262291ENST00000579456VMP1chr17

57816308

+CLTCchr17

57721637

+
In-frameENST00000262291ENST00000579456VMP1chr17

57816308

+CLTCchr17

57721636

+
In-frameENST00000536180ENST00000269122VMP1chr17

57816308

+CLTCchr17

57721637

+
In-frameENST00000536180ENST00000269122VMP1chr17

57816308

+CLTCchr17

57721636

+
In-frameENST00000536180ENST00000393043VMP1chr17

57816308

+CLTCchr17

57721637

+
In-frameENST00000536180ENST00000393043VMP1chr17

57816308

+CLTCchr17

57721636

+
In-frameENST00000536180ENST00000579456VMP1chr17

57816308

+CLTCchr17

57721637

+
In-frameENST00000536180ENST00000579456VMP1chr17

57816308

+CLTCchr17

57721636

+
In-frameENST00000545362ENST00000269122VMP1chr17

57816308

+CLTCchr17

57721637

+
In-frameENST00000545362ENST00000269122VMP1chr17

57816308

+CLTCchr17

57721636

+
In-frameENST00000545362ENST00000393043VMP1chr17

57816308

+CLTCchr17

57721637

+
In-frameENST00000545362ENST00000393043VMP1chr17

57816308

+CLTCchr17

57721636

+
In-frameENST00000545362ENST00000579456VMP1chr17

57816308

+CLTCchr17

57721637

+
In-frameENST00000545362ENST00000579456VMP1chr17

57816308

+CLTCchr17

57721636

+
intron-3CDSENST00000537567ENST00000269122VMP1chr17

57816308

+CLTCchr17

57721637

+
intron-3CDSENST00000537567ENST00000269122VMP1chr17

57816308

+CLTCchr17

57721636

+
intron-3CDSENST00000537567ENST00000393043VMP1chr17

57816308

+CLTCchr17

57721637

+
intron-3CDSENST00000537567ENST00000393043VMP1chr17

57816308

+CLTCchr17

57721636

+
intron-3CDSENST00000537567ENST00000579456VMP1chr17

57816308

+CLTCchr17

57721637

+
intron-3CDSENST00000537567ENST00000579456VMP1chr17

57816308

+CLTCchr17

57721636

+
intron-3CDSENST00000588617ENST00000269122VMP1chr17

57816308

+CLTCchr17

57721637

+
intron-3CDSENST00000588617ENST00000269122VMP1chr17

57816308

+CLTCchr17

57721636

+
intron-3CDSENST00000588617ENST00000393043VMP1chr17

57816308

+CLTCchr17

57721637

+
intron-3CDSENST00000588617ENST00000393043VMP1chr17

57816308

+CLTCchr17

57721636

+
intron-3CDSENST00000588617ENST00000579456VMP1chr17

57816308

+CLTCchr17

57721637

+
intron-3CDSENST00000588617ENST00000579456VMP1chr17

57816308

+CLTCchr17

57721636

+
intron-intronENST00000537567ENST00000579815VMP1chr17

57816308

+CLTCchr17

57721637

+
intron-intronENST00000537567ENST00000579815VMP1chr17

57816308

+CLTCchr17

57721636

+
intron-intronENST00000588617ENST00000269122VMP1chr17

57785109

+CLTCchr17

57771089

+
intron-intronENST00000588617ENST00000269122VMP1chr17

57785109

+CLTCchr17

57771088

+
intron-intronENST00000588617ENST00000393043VMP1chr17

57785109

+CLTCchr17

57771089

+
intron-intronENST00000588617ENST00000393043VMP1chr17

57785109

+CLTCchr17

57771088

+
intron-intronENST00000588617ENST00000579456VMP1chr17

57785109

+CLTCchr17

57771089

+
intron-intronENST00000588617ENST00000579456VMP1chr17

57785109

+CLTCchr17

57771088

+
intron-intronENST00000588617ENST00000579815VMP1chr17

57816308

+CLTCchr17

57721637

+
intron-intronENST00000588617ENST00000579815VMP1chr17

57816308

+CLTCchr17

57721636

+
intron-intronENST00000588617ENST00000579815VMP1chr17

57785109

+CLTCchr17

57771089

+
intron-intronENST00000588617ENST00000579815VMP1chr17

57785109

+CLTCchr17

57771088

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for VMP1-CLTC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
VMP1chr1757785109+CLTCchr1757771088+2.88E-060.99999714
VMP1chr1757785109+CLTCchr1757771088+2.88E-060.99999714
VMP1chr1757816308+CLTCchr1757721636+2.81E-101
VMP1chr1757816308+CLTCchr1757721636+2.81E-101
VMP1chr1757785109+CLTCchr1757771088+2.88E-060.99999714
VMP1chr1757785109+CLTCchr1757771088+2.88E-060.99999714
VMP1chr1757816308+CLTCchr1757721636+2.81E-101
VMP1chr1757816308+CLTCchr1757721636+2.81E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for VMP1-CLTC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57733388/chr17:57915656)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CLTC

P53675

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+5122_43138407.0Topological domainCytoplasmic
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+51265_77138407.0Topological domainExtracellular
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+51299_109138407.0Topological domainCytoplasmic
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+5122_43138407.0Topological domainCytoplasmic
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+51265_77138407.0Topological domainExtracellular
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+51299_109138407.0Topological domainCytoplasmic
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+512110_130138407.0TransmembraneHelical
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+51244_64138407.0TransmembraneHelical
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+51278_98138407.0TransmembraneHelical
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+512110_130138407.0TransmembraneHelical
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+51244_64138407.0TransmembraneHelical
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+51278_98138407.0TransmembraneHelical
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032108_149141676.0RegionNote=WD40-like repeat 3
TgeneCLTCchr17:57816308chr17:57721636ENST000002691220321213_1522141676.0RegionInvolved in binding clathrin light chain
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032150_195141676.0RegionNote=WD40-like repeat 4
TgeneCLTCchr17:57816308chr17:57721636ENST000002691220321550_1675141676.0RegionTrimerization
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032196_257141676.0RegionNote=WD40-like repeat 5
TgeneCLTCchr17:57816308chr17:57721636ENST0000026912203224_67141676.0RegionNote=WD40-like repeat 1
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032258_301141676.0RegionNote=WD40-like repeat 6
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032302_330141676.0RegionNote=WD40-like repeat 7
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032449_465141676.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032480_523141676.0RegionNote=Flexible linker
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032524_1675141676.0RegionNote=Heavy chain arm
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032524_634141676.0RegionNote=Distal segment
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032639_1675141676.0RegionNote=Proximal segment
TgeneCLTCchr17:57816308chr17:57721636ENST0000026912203268_107141676.0RegionNote=WD40-like repeat 2
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031108_149141640.0RegionNote=WD40-like repeat 3
TgeneCLTCchr17:57816308chr17:57721636ENST000003930430311213_1522141640.0RegionInvolved in binding clathrin light chain
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031150_195141640.0RegionNote=WD40-like repeat 4
TgeneCLTCchr17:57816308chr17:57721636ENST000003930430311550_1675141640.0RegionTrimerization
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031196_257141640.0RegionNote=WD40-like repeat 5
TgeneCLTCchr17:57816308chr17:57721636ENST0000039304303124_67141640.0RegionNote=WD40-like repeat 1
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031258_301141640.0RegionNote=WD40-like repeat 6
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031302_330141640.0RegionNote=WD40-like repeat 7
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031449_465141640.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031480_523141640.0RegionNote=Flexible linker
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031524_1675141640.0RegionNote=Heavy chain arm
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031524_634141640.0RegionNote=Distal segment
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031639_1675141640.0RegionNote=Proximal segment
TgeneCLTCchr17:57816308chr17:57721636ENST0000039304303168_107141640.0RegionNote=WD40-like repeat 2
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032108_149141676.0RegionNote=WD40-like repeat 3
TgeneCLTCchr17:57816308chr17:57721637ENST000002691220321213_1522141676.0RegionInvolved in binding clathrin light chain
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032150_195141676.0RegionNote=WD40-like repeat 4
TgeneCLTCchr17:57816308chr17:57721637ENST000002691220321550_1675141676.0RegionTrimerization
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032196_257141676.0RegionNote=WD40-like repeat 5
TgeneCLTCchr17:57816308chr17:57721637ENST0000026912203224_67141676.0RegionNote=WD40-like repeat 1
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032258_301141676.0RegionNote=WD40-like repeat 6
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032302_330141676.0RegionNote=WD40-like repeat 7
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032449_465141676.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032480_523141676.0RegionNote=Flexible linker
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032524_1675141676.0RegionNote=Heavy chain arm
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032524_634141676.0RegionNote=Distal segment
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032639_1675141676.0RegionNote=Proximal segment
TgeneCLTCchr17:57816308chr17:57721637ENST0000026912203268_107141676.0RegionNote=WD40-like repeat 2
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031108_149141640.0RegionNote=WD40-like repeat 3
TgeneCLTCchr17:57816308chr17:57721637ENST000003930430311213_1522141640.0RegionInvolved in binding clathrin light chain
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031150_195141640.0RegionNote=WD40-like repeat 4
TgeneCLTCchr17:57816308chr17:57721637ENST000003930430311550_1675141640.0RegionTrimerization
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031196_257141640.0RegionNote=WD40-like repeat 5
TgeneCLTCchr17:57816308chr17:57721637ENST0000039304303124_67141640.0RegionNote=WD40-like repeat 1
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031258_301141640.0RegionNote=WD40-like repeat 6
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031302_330141640.0RegionNote=WD40-like repeat 7
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031449_465141640.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031480_523141640.0RegionNote=Flexible linker
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031524_1675141640.0RegionNote=Heavy chain arm
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031524_634141640.0RegionNote=Distal segment
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031639_1675141640.0RegionNote=Proximal segment
TgeneCLTCchr17:57816308chr17:57721637ENST0000039304303168_107141640.0RegionNote=WD40-like repeat 2
TgeneCLTCchr17:57816308chr17:57721636ENST000002691220321128_1269141676.0RepeatCHCR 5
TgeneCLTCchr17:57816308chr17:57721636ENST000002691220321274_1420141676.0RepeatCHCR 6
TgeneCLTCchr17:57816308chr17:57721636ENST000002691220321423_1566141676.0RepeatCHCR 7
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032537_683141676.0RepeatCHCR 1
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032686_828141676.0RepeatCHCR 2
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032833_972141676.0RepeatCHCR 3
TgeneCLTCchr17:57816308chr17:57721636ENST00000269122032979_1124141676.0RepeatCHCR 4
TgeneCLTCchr17:57816308chr17:57721636ENST000003930430311128_1269141640.0RepeatCHCR 5
TgeneCLTCchr17:57816308chr17:57721636ENST000003930430311274_1420141640.0RepeatCHCR 6
TgeneCLTCchr17:57816308chr17:57721636ENST000003930430311423_1566141640.0RepeatCHCR 7
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031537_683141640.0RepeatCHCR 1
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031686_828141640.0RepeatCHCR 2
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031833_972141640.0RepeatCHCR 3
TgeneCLTCchr17:57816308chr17:57721636ENST00000393043031979_1124141640.0RepeatCHCR 4
TgeneCLTCchr17:57816308chr17:57721637ENST000002691220321128_1269141676.0RepeatCHCR 5
TgeneCLTCchr17:57816308chr17:57721637ENST000002691220321274_1420141676.0RepeatCHCR 6
TgeneCLTCchr17:57816308chr17:57721637ENST000002691220321423_1566141676.0RepeatCHCR 7
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032537_683141676.0RepeatCHCR 1
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032686_828141676.0RepeatCHCR 2
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032833_972141676.0RepeatCHCR 3
TgeneCLTCchr17:57816308chr17:57721637ENST00000269122032979_1124141676.0RepeatCHCR 4
TgeneCLTCchr17:57816308chr17:57721637ENST000003930430311128_1269141640.0RepeatCHCR 5
TgeneCLTCchr17:57816308chr17:57721637ENST000003930430311274_1420141640.0RepeatCHCR 6
TgeneCLTCchr17:57816308chr17:57721637ENST000003930430311423_1566141640.0RepeatCHCR 7
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031537_683141640.0RepeatCHCR 1
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031686_828141640.0RepeatCHCR 2
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031833_972141640.0RepeatCHCR 3
TgeneCLTCchr17:57816308chr17:57721637ENST00000393043031979_1124141640.0RepeatCHCR 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+512173_316138407.0RegionVTT domain
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+512173_316138407.0RegionVTT domain
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+512131_250138407.0Topological domainExtracellular
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+512272_273138407.0Topological domainCytoplasmic
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+512295_305138407.0Topological domainExtracellular
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+512327_363138407.0Topological domainCytoplasmic
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+512385_406138407.0Topological domainExtracellular
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+512131_250138407.0Topological domainExtracellular
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+512272_273138407.0Topological domainCytoplasmic
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+512295_305138407.0Topological domainExtracellular
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+512327_363138407.0Topological domainCytoplasmic
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+512385_406138407.0Topological domainExtracellular
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+512251_271138407.0TransmembraneHelical
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+512274_294138407.0TransmembraneHelical
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+512306_326138407.0TransmembraneHelical
HgeneVMP1chr17:57816308chr17:57721636ENST00000262291+512364_384138407.0TransmembraneHelical
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+512251_271138407.0TransmembraneHelical
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+512274_294138407.0TransmembraneHelical
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+512306_326138407.0TransmembraneHelical
HgeneVMP1chr17:57816308chr17:57721637ENST00000262291+512364_384138407.0TransmembraneHelical
TgeneCLTCchr17:57816308chr17:57721636ENST000002691220322_479141676.0RegionNote=Globular terminal domain
TgeneCLTCchr17:57816308chr17:57721636ENST000003930430312_479141640.0RegionNote=Globular terminal domain
TgeneCLTCchr17:57816308chr17:57721637ENST000002691220322_479141676.0RegionNote=Globular terminal domain
TgeneCLTCchr17:57816308chr17:57721637ENST000003930430312_479141640.0RegionNote=Globular terminal domain


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Fusion Gene Sequence for VMP1-CLTC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for VMP1-CLTC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VMP1-CLTC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VMP1-CLTC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource