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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:VOPP1-MDM2 (FusionGDB2 ID:98236)

Fusion Gene Summary for VOPP1-MDM2

Fusion gene summary

Fusion gene information	Fusion gene name: VOPP1-MDM2
	Fusion gene ID: 98236
		Hgene	Tgene
	Gene symbol	VOPP1	MDM2
	Gene ID	81552	4193
	Gene name	VOPP1 WW domain binding protein	MDM2 proto-oncogene
	Synonyms	ECOP\|GASP\|WBP1L2	ACTFS\|HDMX\|LSKB\|hdm2
	Cytomap	7p11.2	12q15
	Type of gene	protein-coding	protein-coding
	Description	vesicular, overexpressed in cancer, prosurvival protein 1EGFR-coamplified and overexpressed proteinGlioblastoma-amplified secreted proteinVOPP1, WBP1/VOPP1 family memberhypothetical protein DKFZp564K0822putative NF-kappa-B-activating protein 055N	E3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum
	Modification date	20200313	20200329
	UniProtAcc	.	Q00987
	Ensembl transtripts involved in fusion gene	ENST00000285279, ENST00000427700, ENST00000418904, ENST00000428097, ENST00000428648, ENST00000433959, ENST00000453256, ENST00000454227, ENST00000471168, ENST00000545390,	ENST00000258148, ENST00000258149, ENST00000299252, ENST00000348801, ENST00000350057, ENST00000356290, ENST00000360430, ENST00000393410, ENST00000393412, ENST00000393413, ENST00000428863, ENST00000478070, ENST00000517852, ENST00000540827, ENST00000544125, ENST00000544561, ENST00000545204, ENST00000462284,
Fusion gene scores	* DoF score	7 X 5 X 5=175	12 X 10 X 6=720
	# samples	8	12
	** MAII score	log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: VOPP1 [Title/Abstract] AND MDM2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	VOPP1(55639963)-MDM2(69218142), # samples:1
Anticipated loss of major functional domain due to fusion event.	VOPP1-MDM2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. VOPP1-MDM2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MDM2	GO:0000122	negative regulation of transcription by RNA polymerase II	9271120\|17310983
Tgene	MDM2	GO:0006511	ubiquitin-dependent protein catabolic process	11278372\|15314173\|16173922\|17310983
Tgene	MDM2	GO:0016567	protein ubiquitination	9450543\|15878855\|19656744\|20153724
Tgene	MDM2	GO:0031648	protein destabilization	9529249\|10360174\|15314173
Tgene	MDM2	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	11278372
Tgene	MDM2	GO:0034504	protein localization to nucleus	10360174
Tgene	MDM2	GO:0042176	regulation of protein catabolic process	9153395
Tgene	MDM2	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	9529249\|10360174
Tgene	MDM2	GO:0045184	establishment of protein localization	10360174
Tgene	MDM2	GO:0045892	negative regulation of transcription, DNA-templated	9271120
Tgene	MDM2	GO:0065003	protein-containing complex assembly	10608892\|12915590
Tgene	MDM2	GO:0071157	negative regulation of cell cycle arrest	9529249
Tgene	MDM2	GO:0071480	cellular response to gamma radiation	16213212
Tgene	MDM2	GO:0072717	cellular response to actinomycin D	15314173
Tgene	MDM2	GO:1901797	negative regulation of signal transduction by p53 class mediator	16173922

Fusion gene breakpoints across VOPP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MDM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-19-2624	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+

Top

Fusion Gene ORF analysis for VOPP1-MDM2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000285279	ENST00000258148	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000258149	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000299252	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000348801	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000350057	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000356290	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000360430	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000393410	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000393412	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000393413	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000428863	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000478070	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000517852	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000540827	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000544125	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000544561	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5CDS-intron	ENST00000285279	ENST00000545204	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-3CDS	ENST00000427700	ENST00000462284	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000258148	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000258149	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000299252	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000348801	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000350057	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000356290	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000360430	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000393410	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000393412	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000393413	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000428863	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000478070	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000517852	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000540827	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000544125	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000544561	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
5UTR-intron	ENST00000427700	ENST00000545204	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
Frame-shift	ENST00000285279	ENST00000462284	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-3CDS	ENST00000418904	ENST00000462284	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-3CDS	ENST00000428097	ENST00000462284	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-3CDS	ENST00000428648	ENST00000462284	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-3CDS	ENST00000433959	ENST00000462284	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-3CDS	ENST00000453256	ENST00000462284	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-3CDS	ENST00000454227	ENST00000462284	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-3CDS	ENST00000471168	ENST00000462284	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-3CDS	ENST00000545390	ENST00000462284	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000258148	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000258149	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000299252	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000348801	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000350057	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000356290	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000360430	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000393410	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000393412	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000393413	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000428863	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000478070	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000517852	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000540827	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000544125	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000544561	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000418904	ENST00000545204	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000258148	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000258149	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000299252	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000348801	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000350057	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000356290	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000360430	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000393410	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000393412	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000393413	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000428863	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000478070	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000517852	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000540827	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000544125	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000544561	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428097	ENST00000545204	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000258148	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000258149	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000299252	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000348801	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000350057	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000356290	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000360430	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000393410	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000393412	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000393413	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000428863	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000478070	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000517852	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000540827	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000544125	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000544561	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000428648	ENST00000545204	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000258148	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000258149	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000299252	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000348801	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000350057	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000356290	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000360430	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000393410	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000393412	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000393413	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000428863	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000478070	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000517852	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000540827	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000544125	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000544561	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000433959	ENST00000545204	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000258148	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000258149	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000299252	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000348801	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000350057	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000356290	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000360430	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000393410	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000393412	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000393413	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000428863	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000478070	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000517852	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000540827	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000544125	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000544561	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000453256	ENST00000545204	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000258148	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000258149	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000299252	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000348801	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000350057	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000356290	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000360430	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000393410	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000393412	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000393413	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000428863	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000478070	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000517852	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000540827	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000544125	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000544561	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000454227	ENST00000545204	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000258148	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000258149	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000299252	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000348801	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000350057	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000356290	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000360430	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000393410	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000393412	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000393413	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000428863	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000478070	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000517852	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000540827	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000544125	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000544561	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000471168	ENST00000545204	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000258148	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000258149	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000299252	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000348801	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000350057	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000356290	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000360430	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000393410	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000393412	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000393413	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000428863	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000478070	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000517852	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000540827	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000544125	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000544561	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+
intron-intron	ENST00000545390	ENST00000545204	VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for VOPP1-MDM2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+	6.88E-06	0.9999931
VOPP1	chr7	55639963	-	MDM2	chr12	69218142	+	6.88E-06	0.9999931

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VOPP1-MDM2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:55639963/:69218142)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MDM2 Q00987
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250\|UniProtKB:P23804, ECO:0000269\|PubMed:12821780, ECO:0000269\|PubMed:15053880, ECO:0000269\|PubMed:15195100, ECO:0000269\|PubMed:15632057, ECO:0000269\|PubMed:16337594, ECO:0000269\|PubMed:17290220, ECO:0000269\|PubMed:19098711, ECO:0000269\|PubMed:19219073, ECO:0000269\|PubMed:19837670, ECO:0000269\|PubMed:19965871, ECO:0000269\|PubMed:20173098, ECO:0000269\|PubMed:20385133, ECO:0000269\|PubMed:20858735, ECO:0000269\|PubMed:22128911, ECO:0000269\|PubMed:30879903}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for VOPP1-MDM2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for VOPP1-MDM2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for VOPP1-MDM2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for VOPP1-MDM2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source