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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:VPS13B-CPQ (FusionGDB2 ID:98269)

Fusion Gene Summary for VPS13B-CPQ

Fusion gene summary

Fusion gene information	Fusion gene name: VPS13B-CPQ
	Fusion gene ID: 98269
		Hgene	Tgene
	Gene symbol	VPS13B	CPQ
	Gene ID	157680	10404
	Gene name	vacuolar protein sorting 13 homolog B	carboxypeptidase Q
	Synonyms	CHS1\|COH1	LDP\|PGCP
	Cytomap	8q22.2	8q22.1
	Type of gene	protein-coding	protein-coding
	Description	vacuolar protein sorting-associated protein 13B	carboxypeptidase QSer-Met dipeptidaseaminopeptidaseblood plasma glutamate carboxypeptidaselysosomal dipeptidase
	Modification date	20200313	20200313
	UniProtAcc	.	Q9Y646
	Ensembl transtripts involved in fusion gene	ENST00000395996, ENST00000357162, ENST00000358544, ENST00000355155, ENST00000441350, ENST00000521932,	ENST00000220763, ENST00000529551,
Fusion gene scores	* DoF score	43 X 36 X 17=26316	16 X 14 X 11=2464
	# samples	50	19
	** MAII score	log2(50/26316*10)=-5.71786831273266 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/2464*10)=-3.69693093236395 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: VPS13B [Title/Abstract] AND CPQ [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	VPS13B(100733275)-CPQ(98078236), # samples:1 VPS13B(100733275)-CPQ(98078237), # samples:1 VPS13B(100733275)-CPQ(98067757), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CPQ	GO:0006508	proteolysis	10206990
Tgene	CPQ	GO:0043171	peptide catabolic process	10206990

Fusion gene breakpoints across VPS13B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CPQ (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-20-0987-01A	VPS13B	chr8	100733275	+	CPQ	chr8	98067757	+
ChimerDB4	OV	TCGA-20-0987-01A	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+
ChimerDB4	OV	TCGA-20-0987	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+

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Fusion Gene ORF analysis for VPS13B-CPQ

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000395996	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+
3UTR-3CDS	ENST00000395996	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+
3UTR-3UTR	ENST00000395996	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+
3UTR-3UTR	ENST00000395996	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+
3UTR-intron	ENST00000395996	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98067757	+
3UTR-intron	ENST00000395996	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98067757	+
5CDS-3UTR	ENST00000357162	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+
5CDS-3UTR	ENST00000357162	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+
5CDS-3UTR	ENST00000358544	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+
5CDS-3UTR	ENST00000358544	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+
5CDS-intron	ENST00000357162	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98067757	+
5CDS-intron	ENST00000357162	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98067757	+
5CDS-intron	ENST00000358544	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98067757	+
5CDS-intron	ENST00000358544	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98067757	+
In-frame	ENST00000357162	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+
In-frame	ENST00000357162	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+
In-frame	ENST00000358544	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+
In-frame	ENST00000358544	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+
intron-3CDS	ENST00000355155	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+
intron-3CDS	ENST00000355155	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+
intron-3CDS	ENST00000441350	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+
intron-3CDS	ENST00000441350	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+
intron-3CDS	ENST00000521932	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+
intron-3CDS	ENST00000521932	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+
intron-3UTR	ENST00000355155	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+
intron-3UTR	ENST00000355155	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+
intron-3UTR	ENST00000441350	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+
intron-3UTR	ENST00000441350	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+
intron-3UTR	ENST00000521932	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+
intron-3UTR	ENST00000521932	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+
intron-intron	ENST00000355155	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98067757	+
intron-intron	ENST00000355155	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98067757	+
intron-intron	ENST00000441350	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98067757	+
intron-intron	ENST00000441350	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98067757	+
intron-intron	ENST00000521932	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98067757	+
intron-intron	ENST00000521932	ENST00000529551	VPS13B	chr8	100733275	+	CPQ	chr8	98067757	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000358544

VPS13B

chr8

100733275

ENST00000220763

CPQ

chr8

98078236

7920

7236

111

7601

2496

ENST00000357162

VPS13B

chr8

100733275

ENST00000220763

CPQ

chr8

98078236

7845

7161

111

7526

2471

ENST00000358544

VPS13B

chr8

100733275

ENST00000220763

CPQ

chr8

98078237

7920

7236

111

7601

2496

ENST00000357162

VPS13B

chr8

100733275

ENST00000220763

CPQ

chr8

98078237

7845

7161

111

7526

2471

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000358544	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+	0.000201547	0.9997985
ENST00000357162	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+	0.00021972	0.99978024
ENST00000358544	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+	0.000201547	0.9997985
ENST00000357162	ENST00000220763	VPS13B	chr8	100733275	+	CPQ	chr8	98078237	+	0.00021972	0.99978024

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Fusion Genomic Features for VPS13B-CPQ

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
VPS13B	chr8	100733275	+	CPQ	chr8	98067754	+	0.99565387	0.00434614
VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+	0.002008492	0.99799156
VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+	0.002008492	0.99799156
VPS13B	chr8	100733275	+	CPQ	chr8	98067754	+	0.99565387	0.00434614
VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+	0.002008492	0.99799156
VPS13B	chr8	100733275	+	CPQ	chr8	98078236	+	0.002008492	0.99799156

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VPS13B-CPQ

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:100733275/chr8:98078236)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CPQ Q9Y646
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for VPS13B-CPQ

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>98269_98269_1_VPS13B-CPQ_VPS13B_chr8_100733275_ENST00000357162_CPQ_chr8_98078236_ENST00000220763_length(transcript)=7845nt_BP=7161nt
GGCGCGGTACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTCTTCCGAC
TTCGACTCCTTACCTTAAAAGATGCTGGAGTCATATGTAACTCCAATTTTAATGAGCTATGTGAATCGCTACATCAAGAACTTAAAGCCG
TCGGATCTACAGCTTTCACTATGGGGTGGAGACGTGGTACTCAGCAAGCTCGAGTTAAAGTTGGATGTGCTGGAACAGGAACTGAAATTA
CCATTCACTTTTTTAAGTGGACATATTCATGAATTGAGGATTCATGTACCATGGACAAAACTGGGTTCAGAACCAGTGGTAATTACCATC
AATACTATGGAATGCATTTTGAAACTTAAGGATGGGATACAGGATGACCATGAAAGCTGTGGTTCTAATTCTACCAACCGTAGTACTGCT
GAGAGCACAAAATCATCAATCAAACCGCGGAGAATGCAGCAGGCTGCTCCTACAGATCCTGACTTACCACCAGGTTATGTGCAGAGTCTG
ATTAGACGAGTTGTAAATAATGTAAACATTGTGATAAATAATCTCATACTAAAATATGTTGAAGATGATATCGTCCTTTCCGTCAATATC
ACTTCTGCAGAATGTTATACAGTAGGTGAATTATGGGATCGTGCATTCATGGATATTTCTGCAACTGATTTGGTGCTGAGAAAGGTTATC
AATTTTTCTGACTGTACAGTTTGTCTTGATAAACGGAATGCCAGTGGTAAAATAGAATTTTACCAGGATCCTTTATTATACAAATGTTCC
TTCAGAACTCGTCTTCATTTTACATATGAAAACCTAAATTCCAAGATGCCATCTGTTATTAAAATTCATACTTTAGTGGAAAGTTTGAAA
CTTTCTATCACAGATCAACAACTGCCTATGTTTATTCGTATAATGCAACTTGGAATTGCTCTTTACTATGGAGAAATAGGCAATTTTAAA
GAAGGCGAAATAGAGGACCTTACTTGTCATAATAAAGATATGCTAGGAAACATTACAGGTTCTGAAGATGAAACAAGAATAGATATGCAA
TATCCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAGCAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTG
CCTGCAATTGTGAGTTATGACGATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCACAGACTTTG
AAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACTTTCAAACTCACAGAAATGCAAGTTGAGAGTAGTTATTAC
AGTCCACAGAAAGTAAAATCTAAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAGGCCCTTATGATGGGAGAACCTTTCTTT
GATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAAAGGAATTATGGGTGTTAAAGATTTTGAAGAGAATATGAATAGAAGT
GAAACTGAAGCCTGTTTCTTCATTTGTGGTGACAATTTGAGTACGAAAGGTTTCACATACCTTACAAATTCATTGTTTGATTACCGAAGC
CCAGAAAATAATGGTACTCGCGCAGAATTTATCTTGGATTCAACTCATCATAAGGAGACATACACTGAGATAGCTGGAATGCAACGGTTT
GGGGCTTTTTATATGGATTACCTGTATACAATGGAGAACACTAGTGGCAAAGGTTCCACAAATCAACAAGACTTTTCTTCAGGGAAAAGT
GAAGATTTGGGAACAGTTCAGGAGAAGTCCACCAAAAGCCTTGTTATAGGTCCTCTTGATTTTCGTTTGGATAGCAGTGCGGTGCATAGG
ATTTTGAAAATGATTGTGTGTGCCTTGGAACATGAATATGAACCATATAGCAGGCTAAAATCAGATATTAAGGATGAAAATGAAACAATA
CTGAATCCTGAAGAGGTGGCTCTTCTGGAGGAATATATTCCTACTCGACATACAAGTGTTACTCTCCTCAAATGTACCTGCACAATTTCC
ATGGCTGAATTCAACTTGCTGGACCATTTACTACCTGTCATTATGGGAGAAAAGAACTCAAGTAACTTCATGAATACTACAAACTTCCAG
TCTCTTCGGCCTTTGCCATCCATTCGAATATTGGTGGATAAAATTAATCTGGAACATTCAGTGCCAATGTATGCTGAACAGTTGGTGCAT
GTGGTCAGCAGCCTTACTCAACCTTCTGATAACCTGCTTCATTATTGTTATGTACACTGCTATCTTAAGATATTTGGTTTCCAGGCAGGA
CTGACGTCTTTGGATTGCAGTGGATCTTACTGCTTACCTGTACCAGTTATTCCCTCTTTCAGCACTGCTCTTTATGGGAAACTTCTGAAA
CTCCCCACATGCTGGACCAAAAGATCTCAGATTGCTATAACTGAAGGTATATTTGAACTTCCAAATCTCACAATTCAAGCTACAAGAGCA
CAGACACTTCTCTTGCAAGCAATATATCAAAGTTGGTCTCATCTTGGAAATGTCAGCTCTTCCGCAGTGATTGAAGCTTTGATAAATGAA
ATCTTCCTAAGTATAGGTGTGAAATCTAAGAATCCCCTGCCAACTCTTGAGGGCTCAATCCAGAATGTTGAATTGAAGTACTGCAGCACA
TCATTGGTCAAATGTGCCTCTGGGACCATGGGATCAATAAAAATTTGTGCCAAAGCCCCAGTTGATAGTGGAAAAGAGAAGTTGATTCCC
TTGCTTCAGGGTCCTTCTGACACTAAAGACCTTCATAGCACCAAGTGGCTCAATGAGAGTAGAAAGCCAGAGTCTCTCTTAGCTCCAGAT
TTGATGGCCTTCACAATCCAAGTTCCACAATATATTGACTACTGCCACAATTCCGGTGCTGTACTTCTTTGCAGTATACAAGGACTAGCA
GTTAATATTGACCCAATCTTATATACGTGGCTCATCTATCAGCCTCAGAAACGAACAAGTAGACATATGCAACAGCAGCCTGTGGTAGCT
GTTCCTCTTGTTATGCCAGTTTGTAGAAGGAAAGAGGATGAGGTGTCTATTGGAAGTGCCCCCTTGGCAAAGCAGCAATCATATCAGGCC
TCTGAATATGCCAGCAGCCCTGTAAAAACAAAAACGGTAACAGAATCCCGCCCATTGTCAGTTCCTGTTAAAGCCATGTTGAATATATCT
GAAAGCTGTAGAAGTCCTGAAGAAAGAATGAAGGAATTTATTGGAATTGTTTGGAATGCAGTGAAGCATCTCACACTACAGCTTGAAGTA
CAATCTTGTTGTGTGTTTATTCCAAATGATAGCCTGCCTTCCCCAAGTACAATTGTATCTGGTGACATTCCTGGAACAGTAAGAAGTTGG
TACCATGGACAAACCAGCATGCCGGGAACACTTGTCCTCTGTTTGCCTCAAATAAAGATTATTAGTGCTGGGCACAAGTATATGGAACCT
CTGCAGGAGATTCCATTTGTTATCCCACGACCCATCCTTGAAGAAGGTGATGCTTTTCCTTGGACGATCAGCTTGCATAATTTCAGCATA
TATACCCTTCTTGGAAAACAAGTGACACTTTGCCTAGTGGAACCTATGGGTTGCACCTCCACTCTAGCTGTCACGTCTCAAAAACTGCTT
GCTACGGGACCTGATACACGACATTCATTTGTTGTCTGTCTCCATGTTGACCTAGAGTCACTAGAGATAAAATGCTCTAATCCCCAGGTC
CAGCTCTTCTATGAACTAACTGATATCATGAATAAGGTCTGGAACAAGATTCAGAAGAGAGGCAATCTCAACCTATCTCCAACCTCTCCA
GAGACCATGGCAGGGCCTGTTCCTACTTCTCCAGTTAGAAGCAGTATAGGCACAGCTCCTCCAGATACCAGCACATGCAGCCCATCTGCT
GACATTGGGACTACTACTGAGGGAGATTCTATACAAGCAGGTGAGGAATCACCATTCTCAGATTCTGTGACCTTGGAACAAACTACAAGT
AATATTGGAGGAACCAGTGGACGTGTTAGTTTATGGATGCAGTGGGTGCTTCCCAAAATTACTATAAAGCTCTTTGCTCCAGATCCTGAA
AATAAAGGCACAGAGGTTTGTATGGTCAGTGAACTAGAAGATCTCAGTGCTTCCATAGATGTCCAGGATGTATATACCAAAGTGAAATGT
AAAATAGAGAGTTTCAATATTGATCACTATAGAAGCAGGCCAGGGGAAGGTTGGCAGTCAGGACATTTTGAAGGAGTATTTCTACAATGC
AAAGAAAAATCTGTGACAACTACAAAACTTCTAGATGGCACTCATCAGCAGCATGGATTCCTCTCTCTGACATACACAAAAGCTGTAACA
AAAAATGTCCGCCACAAGTTAACATCAAGAAATGAGCGAAGAAGTTTTCATAAGTTATCTGAAGGCCTAATGGATGGTTCTCCTCATTTT
CTTCATGAAATTCTTCTTTCAGCACAAGCTTTTGATATTGTTCTTTATTTTCCTTTACTTAATGCCATTGCAAGTATATTTCAAGCAAAA
CTACCAAAGACCCAAAAAGAGAAAAGAAAATCTCCTGGTCAGCCCATGAGGACCCATACACTGACATCCCGCAATTTACCTTTGATTTAT
GTCAACACAAGTGTAATCAGAATTTTTATTCCAAAAACAGAAGAAATGCAGCCAACTGTTGAAGCTAATCAGGCAGCAAAAGAAGACACT
GTGGTTTTGAAGATTGGCTCTGTTGCCATGGCTCCCCAGGCTGACAATCCCCTTGGCAGATCTGTCCTTAGGAAAGATATTTACCAGAGA
GCCTTGAACTTAGGAATTCTTCGAGATCCTGGATCAGAAATCGAAGACAGACAATACCAAATAGATCTGCAGTCCATCAATATTGGTACT
GCACAGTGGCATCAACTAAAACCAGAGAAGGAAAGTGTCTCAGGAGGGGTGGTAACAGAGACTGAAAGGAATTCTCAAAATCCAGCCCTT
GAGTGGAATATGGCCAGCAGCATACGGCGGCATCAAGAAAGGAGAGCAATTTTGACCCCCGTTTTGACAGATTTTTCTGTCCGAATAACT
GGAGCACCTGCTGTCATTTTCACCAAAGTAGTTTCTCCAGAAAATTTGCATACTGAGGAGATTTTAGTGTGTGGCCATTCCTTAGAAGTG
AATATAACCACAAACCTGGACTTCTTCCTAAGTGTGGCTCAAGTTCAACTCTTACATCAGTTAATAGTAGCAAATATGACTGGACTGGAA
CCATCAAACAAGGCTGCAGAGATCTCTAAACAAGAACAGAAAAAAGTGGATATATTTGATGGAGGCATGGCTGAAACCTCATCTCGCTAC
AGTGGTGCTCAGGATAGTGGAATTGGCAGTGACAGTGTTAAAATCAGAATAGTGCAAATAGAGCAGCACAGTGGTGCCAGTCAGCATCGC
ATTGCCCGTCCCTCACGCCAGTCATCAATTGTAAAAAATCTAAATTTTATTCCCTTTGACATATTTATTACTGCAAGTAGAATCTCACTA
ATGACCTATTCCTGTATGGCCTTATCCAAATCGAAATCACAAGAACAGAAGAATAATGAAAAAACAGACAAGAGTTCATTAAATCTCCCA
GAAGTTGATTCAGATGTTGCTAAGCCCAACCAGGCATGTATTTCCACGGTGACAGCAGAAGATCTCTTAAGGAGCAGCATTTCTTTTCCT
TCAGGGAAAAAAATAGGGGTCCTCTCTCTTGAAAGTCTTCATGCATCCACAAGGTCATCTGCTAGACAAGCACTTGGTATAACTATTGTT
CGGCAGCCTGGTCGAAGAGGAACTGGTGACTTACAGCTAGAGCCTTTTCTGTACTTTATTGTGTCCCAGCCTTCCTTGCTTCTGAGTTGT
CACCACAGAAAGCAGCGAGTGGAAGTATCCATTTTTGATGCTGTGCTTAAAGGGGTGGCCTCTGATTACAAATGTATAGATCCTGGGAAG
ACTCTGCCTGAAGCCCTTGATTATTGCACTGTTTGGCTACAGACAGTGCCTGGAGAAATAGACAGCAAAAGTGGTATTCCACCTTCCTTT
ATAACACTACAGATTAAAGACTTTCTGAATGGACCAGCGGATGTCAATTTGGATATATCAAAGCCTTTGAAAGCAAACCTGAGTTTCACC
AAACTGGATCAGATAAACCTTTTTTTAAAGAAGATAAAAAATGCACACAGTTTGGCACATAGTGAAGAGACTTCAGCCATGTCCAACACC
ATGGTGAATAAGGATGATCTTCCAGTCTCCAAATATTACCGTGGAAAGTTGTCTAAACCCAAAATTCATGGTGATGGAGTGCAAAAGATT
TCAGCTCAAGAAAACATGTGGAGAGCTGTTTCCTGCTTTCAAAAAATTTCTGTTCAAACTACTCAGATTGTGATCTCCATGGAAACTGTA
CCCCATACCAGCAAACCATGCCTGTTAGCATCTCTCTCAAACCTCAATGGAAGCCTTAGTGTCAAGGCAACACAAAAAGTACCTGGCATA
ATTCTTGGGTCATCATTTCTACTCAGTATAAACGATTTTCTCCTTAAAACAAGTCTCAAAGAAAGAAGCCGCATTCTGATAGGACCATGT
TGTGCTACTGCCAATCTGGAAGCTAAGTGGTGTAAACACAGCGGGAATCCAGGCCCAGAACAATCCATACCAAAAATATCCATTGACTTA
AGAGGAGGTCTACTACAGGTCTTCTGGGGTCAAGAACATTTGAATTGTTTAGTTCTTCTACATGAATTACTCAATGGATACCTTAATGAG
GAGGGAAATTTTGAAGTACAAGTTTCTGAACCAGTGCCTCAAATGTCATCTCCTGTGGAAAAGAATCAGACATTTAAAAGTGAACAAAGT
TCAGATGACCTACGGACAGGTCTATTTCAGTATGTACAGGATGCTGAATCTTTGAAATTGCCTGGGGTCTATGAAGTCTTATTTTATAAT
GAAACTGAAGATTGCCCAGGGATGATGTTATGGAGATATCCAGAACCTAGAGTACTCACCCTTGTACGAATAACTCCTGTACCTTTTAAC
ACCACAGAGGATCCAGATATTAGCACAGCAGACCTTGGTGATGTGCTACAGGTAAATATTTCCAACTACAGTCTGGTGATGGAGTCTGAC
GCAGGAACCTTCTTACCCACTGGGCTGCAATTCACTGGCAGTGAAAAGGCCAGGGCCATCATGGAGGAGGTTATGAGCCTGCTGCAGCCC
CTCAATATCACTCAGGTCCTGAGCCATGGAGAAGGGACAGACATCAACTTTTGGATCCAAGCTGGAGTGCCTGGAGCCAGTCTACTTGAT
GACTTATACAAGTATTTCTTCTTCCATCACTCCCACGGAGACACCATGACTGTCATGGATCCAAAGCAGATGAATGTTGCTGCTGCTGTT
TGGGCTGTTGTTTCTTATGTTGTTGCAGACATGGAAGAAATGCTGCCTAGGTCCTAGAAACAGTAAGAAAGAAACGTTTTCATGCTTCTG
GCCAGGAATCCTGGGTCTGCAACTTTGGAAAACTCCTCTTCACATAACAATTTCATCCAATTCATCTTCAAAGCACAACTCTATTTCATG
CTTTCTGTTATTATCTTTCTTGATACTTTCCAAATTCTCTGATTCTAGAAAAAGGAATCATTCTCCCCTCCCTCCCACCACATAGAATCA
ACATATGGTAGGGATTACAGTGGGGGCATTTCTTTATATCACCTCTTAAAAACATTGTTTCCACTTTAAAAGTAAACACTTAATAAATTT

>98269_98269_1_VPS13B-CPQ_VPS13B_chr8_100733275_ENST00000357162_CPQ_chr8_98078236_ENST00000220763_length(amino acids)=2471AA_BP=2350
MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELRIHVPWTKLGSEPVVITINTMECIL
KLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYT
VGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQ
LPMFIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQDEEQPQGWVSWAWSFVPAIVSYD
DGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRFGAFYMDY
LYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPEEVA
LLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQ
PSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLLLQA
IYQSWSHLGNVSSSAVIEALINEIFLSIGVKSKNPLPTLEGSIQNVELKYCSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSD
TKDLHSTKWLNESRKPESLLAPDLMAFTIQVPQYIDYCHNSGAVLLCSIQGLAVNIDPILYTWLIYQPQKRTSRHMQQQPVVAVPLVMPV
CRRKEDEVSIGSAPLAKQQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNISESCRSPEERMKEFIGIVWNAVKHLTLQLEVQSCCVFI
PNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISAGHKYMEPLQEIPFVIPRPILEEGDAFPWTISLHNFSIYTLLGKQ
VTLCLVEPMGCTSTLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDIMNKVWNKIQKRGNLNLSPTSPETMAGPV
PTSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEESPFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGTEVC
MVSELEDLSASIDVQDVYTKVKCKIESFNIDHYRSRPGEGWQSGHFEGVFLQCKEKSVTTTKLLDGTHQQHGFLSLTYTKAVTKNVRHKL
TSRNERRSFHKLSEGLMDGSPHFLHEILLSAQAFDIVLYFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYVNTSVIR
IFIPKTEEMQPTVEANQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRDPGSEIEDRQYQIDLQSINIGTAQWHQLK
PEKESVSGGVVTETERNSQNPALEWNMASSIRRHQERRAILTPVLTDFSVRITGAPAVIFTKVVSPENLHTEEILVCGHSLEVNITTNLD
FFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQKKVDIFDGGMAETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSRQ
SSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKSQEQKNNEKTDKSSLNLPEVDSDVAKPNQACISTVTAEDLLRSSISFPSGKKIGV
LSLESLHASTRSSARQALGITIVRQPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCIDPGKTLPEALD
YCTVWLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFTKLDQINLFLKKIKNAHSLAHSEETSAMSNTMVNKDDL
PVSKYYRGKLSKPKIHGDGVQKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPCLLASLSNLNGSLSVKATQKVPGIILGSSFL
LSINDFLLKTSLKERSRILIGPCCATANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVFWGQEHLNCLVLLHELLNGYLNEEGNFEVQ
VSEPVPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQDAESLKLPGVYEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDI
STADLGDVLQVNISNYSLVMESDAGTFLPTGLQFTGSEKARAIMEEVMSLLQPLNITQVLSHGEGTDINFWIQAGVPGASLLDDLYKYFF

--------------------------------------------------------------
>98269_98269_2_VPS13B-CPQ_VPS13B_chr8_100733275_ENST00000357162_CPQ_chr8_98078237_ENST00000220763_length(transcript)=7845nt_BP=7161nt
GGCGCGGTACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTCTTCCGAC
TTCGACTCCTTACCTTAAAAGATGCTGGAGTCATATGTAACTCCAATTTTAATGAGCTATGTGAATCGCTACATCAAGAACTTAAAGCCG
TCGGATCTACAGCTTTCACTATGGGGTGGAGACGTGGTACTCAGCAAGCTCGAGTTAAAGTTGGATGTGCTGGAACAGGAACTGAAATTA
CCATTCACTTTTTTAAGTGGACATATTCATGAATTGAGGATTCATGTACCATGGACAAAACTGGGTTCAGAACCAGTGGTAATTACCATC
AATACTATGGAATGCATTTTGAAACTTAAGGATGGGATACAGGATGACCATGAAAGCTGTGGTTCTAATTCTACCAACCGTAGTACTGCT
GAGAGCACAAAATCATCAATCAAACCGCGGAGAATGCAGCAGGCTGCTCCTACAGATCCTGACTTACCACCAGGTTATGTGCAGAGTCTG
ATTAGACGAGTTGTAAATAATGTAAACATTGTGATAAATAATCTCATACTAAAATATGTTGAAGATGATATCGTCCTTTCCGTCAATATC
ACTTCTGCAGAATGTTATACAGTAGGTGAATTATGGGATCGTGCATTCATGGATATTTCTGCAACTGATTTGGTGCTGAGAAAGGTTATC
AATTTTTCTGACTGTACAGTTTGTCTTGATAAACGGAATGCCAGTGGTAAAATAGAATTTTACCAGGATCCTTTATTATACAAATGTTCC
TTCAGAACTCGTCTTCATTTTACATATGAAAACCTAAATTCCAAGATGCCATCTGTTATTAAAATTCATACTTTAGTGGAAAGTTTGAAA
CTTTCTATCACAGATCAACAACTGCCTATGTTTATTCGTATAATGCAACTTGGAATTGCTCTTTACTATGGAGAAATAGGCAATTTTAAA
GAAGGCGAAATAGAGGACCTTACTTGTCATAATAAAGATATGCTAGGAAACATTACAGGTTCTGAAGATGAAACAAGAATAGATATGCAA
TATCCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAGCAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTG
CCTGCAATTGTGAGTTATGACGATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCACAGACTTTG
AAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACTTTCAAACTCACAGAAATGCAAGTTGAGAGTAGTTATTAC
AGTCCACAGAAAGTAAAATCTAAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAGGCCCTTATGATGGGAGAACCTTTCTTT
GATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAAAGGAATTATGGGTGTTAAAGATTTTGAAGAGAATATGAATAGAAGT
GAAACTGAAGCCTGTTTCTTCATTTGTGGTGACAATTTGAGTACGAAAGGTTTCACATACCTTACAAATTCATTGTTTGATTACCGAAGC
CCAGAAAATAATGGTACTCGCGCAGAATTTATCTTGGATTCAACTCATCATAAGGAGACATACACTGAGATAGCTGGAATGCAACGGTTT
GGGGCTTTTTATATGGATTACCTGTATACAATGGAGAACACTAGTGGCAAAGGTTCCACAAATCAACAAGACTTTTCTTCAGGGAAAAGT
GAAGATTTGGGAACAGTTCAGGAGAAGTCCACCAAAAGCCTTGTTATAGGTCCTCTTGATTTTCGTTTGGATAGCAGTGCGGTGCATAGG
ATTTTGAAAATGATTGTGTGTGCCTTGGAACATGAATATGAACCATATAGCAGGCTAAAATCAGATATTAAGGATGAAAATGAAACAATA
CTGAATCCTGAAGAGGTGGCTCTTCTGGAGGAATATATTCCTACTCGACATACAAGTGTTACTCTCCTCAAATGTACCTGCACAATTTCC
ATGGCTGAATTCAACTTGCTGGACCATTTACTACCTGTCATTATGGGAGAAAAGAACTCAAGTAACTTCATGAATACTACAAACTTCCAG
TCTCTTCGGCCTTTGCCATCCATTCGAATATTGGTGGATAAAATTAATCTGGAACATTCAGTGCCAATGTATGCTGAACAGTTGGTGCAT
GTGGTCAGCAGCCTTACTCAACCTTCTGATAACCTGCTTCATTATTGTTATGTACACTGCTATCTTAAGATATTTGGTTTCCAGGCAGGA
CTGACGTCTTTGGATTGCAGTGGATCTTACTGCTTACCTGTACCAGTTATTCCCTCTTTCAGCACTGCTCTTTATGGGAAACTTCTGAAA
CTCCCCACATGCTGGACCAAAAGATCTCAGATTGCTATAACTGAAGGTATATTTGAACTTCCAAATCTCACAATTCAAGCTACAAGAGCA
CAGACACTTCTCTTGCAAGCAATATATCAAAGTTGGTCTCATCTTGGAAATGTCAGCTCTTCCGCAGTGATTGAAGCTTTGATAAATGAA
ATCTTCCTAAGTATAGGTGTGAAATCTAAGAATCCCCTGCCAACTCTTGAGGGCTCAATCCAGAATGTTGAATTGAAGTACTGCAGCACA
TCATTGGTCAAATGTGCCTCTGGGACCATGGGATCAATAAAAATTTGTGCCAAAGCCCCAGTTGATAGTGGAAAAGAGAAGTTGATTCCC
TTGCTTCAGGGTCCTTCTGACACTAAAGACCTTCATAGCACCAAGTGGCTCAATGAGAGTAGAAAGCCAGAGTCTCTCTTAGCTCCAGAT
TTGATGGCCTTCACAATCCAAGTTCCACAATATATTGACTACTGCCACAATTCCGGTGCTGTACTTCTTTGCAGTATACAAGGACTAGCA
GTTAATATTGACCCAATCTTATATACGTGGCTCATCTATCAGCCTCAGAAACGAACAAGTAGACATATGCAACAGCAGCCTGTGGTAGCT
GTTCCTCTTGTTATGCCAGTTTGTAGAAGGAAAGAGGATGAGGTGTCTATTGGAAGTGCCCCCTTGGCAAAGCAGCAATCATATCAGGCC
TCTGAATATGCCAGCAGCCCTGTAAAAACAAAAACGGTAACAGAATCCCGCCCATTGTCAGTTCCTGTTAAAGCCATGTTGAATATATCT
GAAAGCTGTAGAAGTCCTGAAGAAAGAATGAAGGAATTTATTGGAATTGTTTGGAATGCAGTGAAGCATCTCACACTACAGCTTGAAGTA
CAATCTTGTTGTGTGTTTATTCCAAATGATAGCCTGCCTTCCCCAAGTACAATTGTATCTGGTGACATTCCTGGAACAGTAAGAAGTTGG
TACCATGGACAAACCAGCATGCCGGGAACACTTGTCCTCTGTTTGCCTCAAATAAAGATTATTAGTGCTGGGCACAAGTATATGGAACCT
CTGCAGGAGATTCCATTTGTTATCCCACGACCCATCCTTGAAGAAGGTGATGCTTTTCCTTGGACGATCAGCTTGCATAATTTCAGCATA
TATACCCTTCTTGGAAAACAAGTGACACTTTGCCTAGTGGAACCTATGGGTTGCACCTCCACTCTAGCTGTCACGTCTCAAAAACTGCTT
GCTACGGGACCTGATACACGACATTCATTTGTTGTCTGTCTCCATGTTGACCTAGAGTCACTAGAGATAAAATGCTCTAATCCCCAGGTC
CAGCTCTTCTATGAACTAACTGATATCATGAATAAGGTCTGGAACAAGATTCAGAAGAGAGGCAATCTCAACCTATCTCCAACCTCTCCA
GAGACCATGGCAGGGCCTGTTCCTACTTCTCCAGTTAGAAGCAGTATAGGCACAGCTCCTCCAGATACCAGCACATGCAGCCCATCTGCT
GACATTGGGACTACTACTGAGGGAGATTCTATACAAGCAGGTGAGGAATCACCATTCTCAGATTCTGTGACCTTGGAACAAACTACAAGT
AATATTGGAGGAACCAGTGGACGTGTTAGTTTATGGATGCAGTGGGTGCTTCCCAAAATTACTATAAAGCTCTTTGCTCCAGATCCTGAA
AATAAAGGCACAGAGGTTTGTATGGTCAGTGAACTAGAAGATCTCAGTGCTTCCATAGATGTCCAGGATGTATATACCAAAGTGAAATGT
AAAATAGAGAGTTTCAATATTGATCACTATAGAAGCAGGCCAGGGGAAGGTTGGCAGTCAGGACATTTTGAAGGAGTATTTCTACAATGC
AAAGAAAAATCTGTGACAACTACAAAACTTCTAGATGGCACTCATCAGCAGCATGGATTCCTCTCTCTGACATACACAAAAGCTGTAACA
AAAAATGTCCGCCACAAGTTAACATCAAGAAATGAGCGAAGAAGTTTTCATAAGTTATCTGAAGGCCTAATGGATGGTTCTCCTCATTTT
CTTCATGAAATTCTTCTTTCAGCACAAGCTTTTGATATTGTTCTTTATTTTCCTTTACTTAATGCCATTGCAAGTATATTTCAAGCAAAA
CTACCAAAGACCCAAAAAGAGAAAAGAAAATCTCCTGGTCAGCCCATGAGGACCCATACACTGACATCCCGCAATTTACCTTTGATTTAT
GTCAACACAAGTGTAATCAGAATTTTTATTCCAAAAACAGAAGAAATGCAGCCAACTGTTGAAGCTAATCAGGCAGCAAAAGAAGACACT
GTGGTTTTGAAGATTGGCTCTGTTGCCATGGCTCCCCAGGCTGACAATCCCCTTGGCAGATCTGTCCTTAGGAAAGATATTTACCAGAGA
GCCTTGAACTTAGGAATTCTTCGAGATCCTGGATCAGAAATCGAAGACAGACAATACCAAATAGATCTGCAGTCCATCAATATTGGTACT
GCACAGTGGCATCAACTAAAACCAGAGAAGGAAAGTGTCTCAGGAGGGGTGGTAACAGAGACTGAAAGGAATTCTCAAAATCCAGCCCTT
GAGTGGAATATGGCCAGCAGCATACGGCGGCATCAAGAAAGGAGAGCAATTTTGACCCCCGTTTTGACAGATTTTTCTGTCCGAATAACT
GGAGCACCTGCTGTCATTTTCACCAAAGTAGTTTCTCCAGAAAATTTGCATACTGAGGAGATTTTAGTGTGTGGCCATTCCTTAGAAGTG
AATATAACCACAAACCTGGACTTCTTCCTAAGTGTGGCTCAAGTTCAACTCTTACATCAGTTAATAGTAGCAAATATGACTGGACTGGAA
CCATCAAACAAGGCTGCAGAGATCTCTAAACAAGAACAGAAAAAAGTGGATATATTTGATGGAGGCATGGCTGAAACCTCATCTCGCTAC
AGTGGTGCTCAGGATAGTGGAATTGGCAGTGACAGTGTTAAAATCAGAATAGTGCAAATAGAGCAGCACAGTGGTGCCAGTCAGCATCGC
ATTGCCCGTCCCTCACGCCAGTCATCAATTGTAAAAAATCTAAATTTTATTCCCTTTGACATATTTATTACTGCAAGTAGAATCTCACTA
ATGACCTATTCCTGTATGGCCTTATCCAAATCGAAATCACAAGAACAGAAGAATAATGAAAAAACAGACAAGAGTTCATTAAATCTCCCA
GAAGTTGATTCAGATGTTGCTAAGCCCAACCAGGCATGTATTTCCACGGTGACAGCAGAAGATCTCTTAAGGAGCAGCATTTCTTTTCCT
TCAGGGAAAAAAATAGGGGTCCTCTCTCTTGAAAGTCTTCATGCATCCACAAGGTCATCTGCTAGACAAGCACTTGGTATAACTATTGTT
CGGCAGCCTGGTCGAAGAGGAACTGGTGACTTACAGCTAGAGCCTTTTCTGTACTTTATTGTGTCCCAGCCTTCCTTGCTTCTGAGTTGT
CACCACAGAAAGCAGCGAGTGGAAGTATCCATTTTTGATGCTGTGCTTAAAGGGGTGGCCTCTGATTACAAATGTATAGATCCTGGGAAG
ACTCTGCCTGAAGCCCTTGATTATTGCACTGTTTGGCTACAGACAGTGCCTGGAGAAATAGACAGCAAAAGTGGTATTCCACCTTCCTTT
ATAACACTACAGATTAAAGACTTTCTGAATGGACCAGCGGATGTCAATTTGGATATATCAAAGCCTTTGAAAGCAAACCTGAGTTTCACC
AAACTGGATCAGATAAACCTTTTTTTAAAGAAGATAAAAAATGCACACAGTTTGGCACATAGTGAAGAGACTTCAGCCATGTCCAACACC
ATGGTGAATAAGGATGATCTTCCAGTCTCCAAATATTACCGTGGAAAGTTGTCTAAACCCAAAATTCATGGTGATGGAGTGCAAAAGATT
TCAGCTCAAGAAAACATGTGGAGAGCTGTTTCCTGCTTTCAAAAAATTTCTGTTCAAACTACTCAGATTGTGATCTCCATGGAAACTGTA
CCCCATACCAGCAAACCATGCCTGTTAGCATCTCTCTCAAACCTCAATGGAAGCCTTAGTGTCAAGGCAACACAAAAAGTACCTGGCATA
ATTCTTGGGTCATCATTTCTACTCAGTATAAACGATTTTCTCCTTAAAACAAGTCTCAAAGAAAGAAGCCGCATTCTGATAGGACCATGT
TGTGCTACTGCCAATCTGGAAGCTAAGTGGTGTAAACACAGCGGGAATCCAGGCCCAGAACAATCCATACCAAAAATATCCATTGACTTA
AGAGGAGGTCTACTACAGGTCTTCTGGGGTCAAGAACATTTGAATTGTTTAGTTCTTCTACATGAATTACTCAATGGATACCTTAATGAG
GAGGGAAATTTTGAAGTACAAGTTTCTGAACCAGTGCCTCAAATGTCATCTCCTGTGGAAAAGAATCAGACATTTAAAAGTGAACAAAGT
TCAGATGACCTACGGACAGGTCTATTTCAGTATGTACAGGATGCTGAATCTTTGAAATTGCCTGGGGTCTATGAAGTCTTATTTTATAAT
GAAACTGAAGATTGCCCAGGGATGATGTTATGGAGATATCCAGAACCTAGAGTACTCACCCTTGTACGAATAACTCCTGTACCTTTTAAC
ACCACAGAGGATCCAGATATTAGCACAGCAGACCTTGGTGATGTGCTACAGGTAAATATTTCCAACTACAGTCTGGTGATGGAGTCTGAC
GCAGGAACCTTCTTACCCACTGGGCTGCAATTCACTGGCAGTGAAAAGGCCAGGGCCATCATGGAGGAGGTTATGAGCCTGCTGCAGCCC
CTCAATATCACTCAGGTCCTGAGCCATGGAGAAGGGACAGACATCAACTTTTGGATCCAAGCTGGAGTGCCTGGAGCCAGTCTACTTGAT
GACTTATACAAGTATTTCTTCTTCCATCACTCCCACGGAGACACCATGACTGTCATGGATCCAAAGCAGATGAATGTTGCTGCTGCTGTT
TGGGCTGTTGTTTCTTATGTTGTTGCAGACATGGAAGAAATGCTGCCTAGGTCCTAGAAACAGTAAGAAAGAAACGTTTTCATGCTTCTG
GCCAGGAATCCTGGGTCTGCAACTTTGGAAAACTCCTCTTCACATAACAATTTCATCCAATTCATCTTCAAAGCACAACTCTATTTCATG
CTTTCTGTTATTATCTTTCTTGATACTTTCCAAATTCTCTGATTCTAGAAAAAGGAATCATTCTCCCCTCCCTCCCACCACATAGAATCA
ACATATGGTAGGGATTACAGTGGGGGCATTTCTTTATATCACCTCTTAAAAACATTGTTTCCACTTTAAAAGTAAACACTTAATAAATTT

>98269_98269_2_VPS13B-CPQ_VPS13B_chr8_100733275_ENST00000357162_CPQ_chr8_98078237_ENST00000220763_length(amino acids)=2471AA_BP=2350
MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELRIHVPWTKLGSEPVVITINTMECIL
KLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYT
VGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQ
LPMFIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQDEEQPQGWVSWAWSFVPAIVSYD
DGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRFGAFYMDY
LYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPEEVA
LLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQ
PSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLLLQA
IYQSWSHLGNVSSSAVIEALINEIFLSIGVKSKNPLPTLEGSIQNVELKYCSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSD
TKDLHSTKWLNESRKPESLLAPDLMAFTIQVPQYIDYCHNSGAVLLCSIQGLAVNIDPILYTWLIYQPQKRTSRHMQQQPVVAVPLVMPV
CRRKEDEVSIGSAPLAKQQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNISESCRSPEERMKEFIGIVWNAVKHLTLQLEVQSCCVFI
PNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISAGHKYMEPLQEIPFVIPRPILEEGDAFPWTISLHNFSIYTLLGKQ
VTLCLVEPMGCTSTLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDIMNKVWNKIQKRGNLNLSPTSPETMAGPV
PTSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEESPFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGTEVC
MVSELEDLSASIDVQDVYTKVKCKIESFNIDHYRSRPGEGWQSGHFEGVFLQCKEKSVTTTKLLDGTHQQHGFLSLTYTKAVTKNVRHKL
TSRNERRSFHKLSEGLMDGSPHFLHEILLSAQAFDIVLYFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYVNTSVIR
IFIPKTEEMQPTVEANQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRDPGSEIEDRQYQIDLQSINIGTAQWHQLK
PEKESVSGGVVTETERNSQNPALEWNMASSIRRHQERRAILTPVLTDFSVRITGAPAVIFTKVVSPENLHTEEILVCGHSLEVNITTNLD
FFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQKKVDIFDGGMAETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSRQ
SSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKSQEQKNNEKTDKSSLNLPEVDSDVAKPNQACISTVTAEDLLRSSISFPSGKKIGV
LSLESLHASTRSSARQALGITIVRQPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCIDPGKTLPEALD
YCTVWLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFTKLDQINLFLKKIKNAHSLAHSEETSAMSNTMVNKDDL
PVSKYYRGKLSKPKIHGDGVQKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPCLLASLSNLNGSLSVKATQKVPGIILGSSFL
LSINDFLLKTSLKERSRILIGPCCATANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVFWGQEHLNCLVLLHELLNGYLNEEGNFEVQ
VSEPVPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQDAESLKLPGVYEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDI
STADLGDVLQVNISNYSLVMESDAGTFLPTGLQFTGSEKARAIMEEVMSLLQPLNITQVLSHGEGTDINFWIQAGVPGASLLDDLYKYFF

--------------------------------------------------------------
>98269_98269_3_VPS13B-CPQ_VPS13B_chr8_100733275_ENST00000358544_CPQ_chr8_98078236_ENST00000220763_length(transcript)=7920nt_BP=7236nt
GGCGCGGTACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTCTTCCGAC
TTCGACTCCTTACCTTAAAAGATGCTGGAGTCATATGTAACTCCAATTTTAATGAGCTATGTGAATCGCTACATCAAGAACTTAAAGCCG
TCGGATCTACAGCTTTCACTATGGGGTGGAGACGTGGTACTCAGCAAGCTCGAGTTAAAGTTGGATGTGCTGGAACAGGAACTGAAATTA
CCATTCACTTTTTTAAGTGGACATATTCATGAATTGAGGATTCATGTACCATGGACAAAACTGGGTTCAGAACCAGTGGTAATTACCATC
AATACTATGGAATGCATTTTGAAACTTAAGGATGGGATACAGGATGACCATGAAAGCTGTGGTTCTAATTCTACCAACCGTAGTACTGCT
GAGAGCACAAAATCATCAATCAAACCGCGGAGAATGCAGCAGGCTGCTCCTACAGATCCTGACTTACCACCAGGTTATGTGCAGAGTCTG
ATTAGACGAGTTGTAAATAATGTAAACATTGTGATAAATAATCTCATACTAAAATATGTTGAAGATGATATCGTCCTTTCCGTCAATATC
ACTTCTGCAGAATGTTATACAGTAGGTGAATTATGGGATCGTGCATTCATGGATATTTCTGCAACTGATTTGGTGCTGAGAAAGGTTATC
AATTTTTCTGACTGTACAGTTTGTCTTGATAAACGGAATGCCAGTGGTAAAATAGAATTTTACCAGGATCCTTTATTATACAAATGTTCC
TTCAGAACTCGTCTTCATTTTACATATGAAAACCTAAATTCCAAGATGCCATCTGTTATTAAAATTCATACTTTAGTGGAAAGTTTGAAA
CTTTCTATCACAGATCAACAACTGCCTATGTTTATTCGTATAATGCAACTTGGAATTGCTCTTTACTATGGAGAAATAGGCAATTTTAAA
GAAGGCGAAATAGAGGACCTTACTTGTCATAATAAAGATATGCTAGGAAACATTACAGGTTCTGAAGATGAAACAAGAATAGATATGCAA
TATCCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAGCAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTG
CCTGCAATTGTGAGTTATGACGATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCACAGACTTTG
AAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACTTTCAAACTCACAGAAATGCAAGTTGAGAGTAGTTATTAC
AGTCCACAGAAAGTAAAATCTAAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAGGCCCTTATGATGGGAGAACCTTTCTTT
GATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAAAGGAATTATGGGTGTTAAAGATTTTGAAGAGAATATGAATAGAAGT
GAAACTGAAGCCTGTTTCTTCATTTGTGGTGACAATTTGAGTACGAAAGGTTTCACATACCTTACAAATTCATTGTTTGATTACCGAAGC
CCAGAAAATAATGGTACTCGCGCAGAATTTATCTTGGATTCAACTCATCATAAGGAGACATACACTGAGATAGCTGGAATGCAACGGTTT
GGGGCTTTTTATATGGATTACCTGTATACAATGGAGAACACTAGTGGCAAAGGTTCCACAAATCAACAAGACTTTTCTTCAGGGAAAAGT
GAAGATTTGGGAACAGTTCAGGAGAAGTCCACCAAAAGCCTTGTTATAGGTCCTCTTGATTTTCGTTTGGATAGCAGTGCGGTGCATAGG
ATTTTGAAAATGATTGTGTGTGCCTTGGAACATGAATATGAACCATATAGCAGGCTAAAATCAGATATTAAGGATGAAAATGAAACAATA
CTGAATCCTGAAGAGGTGGCTCTTCTGGAGGAATATATTCCTACTCGACATACAAGTGTTACTCTCCTCAAATGTACCTGCACAATTTCC
ATGGCTGAATTCAACTTGCTGGACCATTTACTACCTGTCATTATGGGAGAAAAGAACTCAAGTAACTTCATGAATACTACAAACTTCCAG
TCTCTTCGGCCTTTGCCATCCATTCGAATATTGGTGGATAAAATTAATCTGGAACATTCAGTGCCAATGTATGCTGAACAGTTGGTGCAT
GTGGTCAGCAGCCTTACTCAACCTTCTGATAACCTGCTTCATTATTGTTATGTACACTGCTATCTTAAGATATTTGGTTTCCAGGCAGGA
CTGACGTCTTTGGATTGCAGTGGATCTTACTGCTTACCTGTACCAGTTATTCCCTCTTTCAGCACTGCTCTTTATGGGAAACTTCTGAAA
CTCCCCACATGCTGGACCAAAAGATCTCAGATTGCTATAACTGAAGGTATATTTGAACTTCCAAATCTCACAATTCAAGCTACAAGAGCA
CAGACACTTCTCTTGCAAGCAATATATCAAAGTTGGTCTCATCTTGGAAATGTCAGCTCTTCCGCAGTGATTGAAGCTTTGATAAATGAA
ATCTTCCTAAGTATAGGTGTGAAATCTAAGAATCCCCTGCCAACTCTTGAGGGCTCAATCCAGAATGTTGAATTGAAGTACTGCAGCACA
TCATTGGTCAAATGTGCCTCTGGGACCATGGGATCAATAAAAATTTGTGCCAAAGCCCCAGTTGATAGTGGAAAAGAGAAGTTGATTCCC
TTGCTTCAGGGTCCTTCTGACACTAAAGACCTTCATAGCACCAAGTGGCTCAATGAGAGTAGAAAGCCAGAGTCTCTCTTAGCTCCAGAT
TTGATGGCCTTCACAATCCAAGTTCCACAATATATTGACTACTGCCACAATTCCGGTGCTGTACTTCTTTGCAGTATACAAGGACTAGCA
GTTAATATTGACCCAATCTTATATACGTGGCTCATCTATCAGCCTCAGAAACGAACAAGTAGACATATGCAACAGCAGCCTGTGGTAGCT
GTTCCTCTTGTTATGCCAGTTTGTAGAAGGAAAGAGGATGAGGTGTCTATTGGAAGTGCCCCCTTGGCAAAGCAGCAATCATATCAGGCC
TCTGAATATGCCAGCAGCCCTGTAAAAACAAAAACGGTAACAGAATCCCGCCCATTGTCAGTTCCTGTTAAAGCCATGTTGAATATATCT
GAAAGCTGTAGAAGTCCTGAAGAAAGAATGAAGGAATTTATTGGAATTGTTTGGAATGCAGTGAAGCATCTCACACTACAGCTTGAAGTA
CAATCTTGTTGTGTGTTTATTCCAAATGATAGCCTGCCTTCCCCAAGTACAATTGTATCTGGTGACATTCCTGGAACAGTAAGAAGTTGG
TACCATGGACAAACCAGCATGCCGGGAACACTTGTCCTCTGTTTGCCTCAAATAAAGATTATTAGTGCTGGGCACAAGTATATGGAACCT
CTGCAGGAGATTCCATTTGTTATCCCACGACCCATCCTTGAAGAAGGTGATGCTTTTCCTTGGACGATCAGCTTGCATAATTTCAGCATA
TATACCCTTCTTGGAAAACAAGTGACACTTTGCCTAGTGGAACCTATGGGTTGCACCTCCACTCTAGCTGTCACGTCTCAAAAACTGCTT
GCTACGGGACCTGATACACGACATTCATTTGTTGTCTGTCTCCATGTTGACCTAGAGTCACTAGAGATAAAATGCTCTAATCCCCAGGTC
CAGCTCTTCTATGAACTAACTGATATCATGAATAAGGTCTGGAACAAGATTCAGAAGAGAGGCAATCTCAACCTATCTCCAACCTCTCCA
GAGACCATGGCAGGGCCTGTTCCTACTTCTCCAGTTAGAAGCAGTATAGGCACAGCTCCTCCAGATACCAGCACATGCAGCCCATCTGCT
GACATTGGGACTACTACTGAGGGAGATTCTATACAAGCAGGTGAGGAATCACCATTCTCAGATTCTGTGACCTTGGAACAAACTACAAGT
AATATTGGAGGAACCAGTGGACGTGTTAGTTTATGGATGCAGTGGGTGCTTCCCAAAATTACTATAAAGCTCTTTGCTCCAGATCCTGAA
AATAAAGGCACAGAGGTTTGTATGGTCAGTGAACTAGAAGATCTCAGTGCTTCCATAGATGTCCAGGATGTATATACCAAAGTGAAATGT
AAAATAGAGAGTTTCAATATTGATCACTATAGAAGCAGCCTTGGGGAAGAGTGTTGGTCTTTGGGGCAATGTGGAGGTGTCTTCCTTTCC
TGTACTGACAAGCTGAACAGACGCACCTTGTTGGTTCGACCCATCAGCAAGCAGGACCCTTTCAGTAATTGCTCTGGCTTCTTTCCTTCT
ACAACTACAAAACTTCTAGATGGCACTCATCAGCAGCATGGATTCCTCTCTCTGACATACACAAAAGCTGTAACAAAAAATGTCCGCCAC
AAGTTAACATCAAGAAATGAGCGAAGAAGTTTTCATAAGTTATCTGAAGGCCTAATGGATGGTTCTCCTCATTTTCTTCATGAAATTCTT
CTTTCAGCACAAGCTTTTGATATTGTTCTTTATTTTCCTTTACTTAATGCCATTGCAAGTATATTTCAAGCAAAACTACCAAAGACCCAA
AAAGAGAAAAGAAAATCTCCTGGTCAGCCCATGAGGACCCATACACTGACATCCCGCAATTTACCTTTGATTTATGTCAACACAAGTGTA
ATCAGAATTTTTATTCCAAAAACAGAAGAAATGCAGCCAACTGTTGAAGCTAATCAGGCAGCAAAAGAAGACACTGTGGTTTTGAAGATT
GGCTCTGTTGCCATGGCTCCCCAGGCTGACAATCCCCTTGGCAGATCTGTCCTTAGGAAAGATATTTACCAGAGAGCCTTGAACTTAGGA
ATTCTTCGAGATCCTGGATCAGAAATCGAAGACAGACAATACCAAATAGATCTGCAGTCCATCAATATTGGTACTGCACAGTGGCATCAA
CTAAAACCAGAGAAGGAAAGTGTCTCAGGAGGGGTGGTAACAGAGACTGAAAGGAATTCTCAAAATCCAGCCCTTGAGTGGAATATGGCC
AGCAGCATACGGCGGCATCAAGAAAGGAGAGCAATTTTGACCCCCGTTTTGACAGATTTTTCTGTCCGAATAACTGGAGCACCTGCTGTC
ATTTTCACCAAAGTAGTTTCTCCAGAAAATTTGCATACTGAGGAGATTTTAGTGTGTGGCCATTCCTTAGAAGTGAATATAACCACAAAC
CTGGACTTCTTCCTAAGTGTGGCTCAAGTTCAACTCTTACATCAGTTAATAGTAGCAAATATGACTGGACTGGAACCATCAAACAAGGCT
GCAGAGATCTCTAAACAAGAACAGAAAAAAGTGGATATATTTGATGGAGGCATGGCTGAAACCTCATCTCGCTACAGTGGTGCTCAGGAT
AGTGGAATTGGCAGTGACAGTGTTAAAATCAGAATAGTGCAAATAGAGCAGCACAGTGGTGCCAGTCAGCATCGCATTGCCCGTCCCTCA
CGCCAGTCATCAATTGTAAAAAATCTAAATTTTATTCCCTTTGACATATTTATTACTGCAAGTAGAATCTCACTAATGACCTATTCCTGT
ATGGCCTTATCCAAATCGAAATCACAAGAACAGAAGAATAATGAAAAAACAGACAAGAGTTCATTAAATCTCCCAGAAGTTGATTCAGAT
GTTGCTAAGCCCAACCAGGCATGTATTTCCACGGTGACAGCAGAAGATCTCTTAAGGAGCAGCATTTCTTTTCCTTCAGGGAAAAAAATA
GGGGTCCTCTCTCTTGAAAGTCTTCATGCATCCACAAGGTCATCTGCTAGACAAGCACTTGGTATAACTATTGTTCGGCAGCCTGGTCGA
AGAGGAACTGGTGACTTACAGCTAGAGCCTTTTCTGTACTTTATTGTGTCCCAGCCTTCCTTGCTTCTGAGTTGTCACCACAGAAAGCAG
CGAGTGGAAGTATCCATTTTTGATGCTGTGCTTAAAGGGGTGGCCTCTGATTACAAATGTATAGATCCTGGGAAGACTCTGCCTGAAGCC
CTTGATTATTGCACTGTTTGGCTACAGACAGTGCCTGGAGAAATAGACAGCAAAAGTGGTATTCCACCTTCCTTTATAACACTACAGATT
AAAGACTTTCTGAATGGACCAGCGGATGTCAATTTGGATATATCAAAGCCTTTGAAAGCAAACCTGAGTTTCACCAAACTGGATCAGATA
AACCTTTTTTTAAAGAAGATAAAAAATGCACACAGTTTGGCACATAGTGAAGAGACTTCAGCCATGTCCAACACCATGGTGAATAAGGAT
GATCTTCCAGTCTCCAAATATTACCGTGGAAAGTTGTCTAAACCCAAAATTCATGGTGATGGAGTGCAAAAGATTTCAGCTCAAGAAAAC
ATGTGGAGAGCTGTTTCCTGCTTTCAAAAAATTTCTGTTCAAACTACTCAGATTGTGATCTCCATGGAAACTGTACCCCATACCAGCAAA
CCATGCCTGTTAGCATCTCTCTCAAACCTCAATGGAAGCCTTAGTGTCAAGGCAACACAAAAAGTACCTGGCATAATTCTTGGGTCATCA
TTTCTACTCAGTATAAACGATTTTCTCCTTAAAACAAGTCTCAAAGAAAGAAGCCGCATTCTGATAGGACCATGTTGTGCTACTGCCAAT
CTGGAAGCTAAGTGGTGTAAACACAGCGGGAATCCAGGCCCAGAACAATCCATACCAAAAATATCCATTGACTTAAGAGGAGGTCTACTA
CAGGTCTTCTGGGGTCAAGAACATTTGAATTGTTTAGTTCTTCTACATGAATTACTCAATGGATACCTTAATGAGGAGGGAAATTTTGAA
GTACAAGTTTCTGAACCAGTGCCTCAAATGTCATCTCCTGTGGAAAAGAATCAGACATTTAAAAGTGAACAAAGTTCAGATGACCTACGG
ACAGGTCTATTTCAGTATGTACAGGATGCTGAATCTTTGAAATTGCCTGGGGTCTATGAAGTCTTATTTTATAATGAAACTGAAGATTGC
CCAGGGATGATGTTATGGAGATATCCAGAACCTAGAGTACTCACCCTTGTACGAATAACTCCTGTACCTTTTAACACCACAGAGGATCCA
GATATTAGCACAGCAGACCTTGGTGATGTGCTACAGGTAAATATTTCCAACTACAGTCTGGTGATGGAGTCTGACGCAGGAACCTTCTTA
CCCACTGGGCTGCAATTCACTGGCAGTGAAAAGGCCAGGGCCATCATGGAGGAGGTTATGAGCCTGCTGCAGCCCCTCAATATCACTCAG
GTCCTGAGCCATGGAGAAGGGACAGACATCAACTTTTGGATCCAAGCTGGAGTGCCTGGAGCCAGTCTACTTGATGACTTATACAAGTAT
TTCTTCTTCCATCACTCCCACGGAGACACCATGACTGTCATGGATCCAAAGCAGATGAATGTTGCTGCTGCTGTTTGGGCTGTTGTTTCT
TATGTTGTTGCAGACATGGAAGAAATGCTGCCTAGGTCCTAGAAACAGTAAGAAAGAAACGTTTTCATGCTTCTGGCCAGGAATCCTGGG
TCTGCAACTTTGGAAAACTCCTCTTCACATAACAATTTCATCCAATTCATCTTCAAAGCACAACTCTATTTCATGCTTTCTGTTATTATC
TTTCTTGATACTTTCCAAATTCTCTGATTCTAGAAAAAGGAATCATTCTCCCCTCCCTCCCACCACATAGAATCAACATATGGTAGGGAT
TACAGTGGGGGCATTTCTTTATATCACCTCTTAAAAACATTGTTTCCACTTTAAAAGTAAACACTTAATAAATTTTTGGAAGATCTCTGA

>98269_98269_3_VPS13B-CPQ_VPS13B_chr8_100733275_ENST00000358544_CPQ_chr8_98078236_ENST00000220763_length(amino acids)=2496AA_BP=2375
MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELRIHVPWTKLGSEPVVITINTMECIL
KLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYT
VGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQ
LPMFIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQDEEQPQGWVSWAWSFVPAIVSYD
DGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRFGAFYMDY
LYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPEEVA
LLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQ
PSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLLLQA
IYQSWSHLGNVSSSAVIEALINEIFLSIGVKSKNPLPTLEGSIQNVELKYCSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSD
TKDLHSTKWLNESRKPESLLAPDLMAFTIQVPQYIDYCHNSGAVLLCSIQGLAVNIDPILYTWLIYQPQKRTSRHMQQQPVVAVPLVMPV
CRRKEDEVSIGSAPLAKQQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNISESCRSPEERMKEFIGIVWNAVKHLTLQLEVQSCCVFI
PNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISAGHKYMEPLQEIPFVIPRPILEEGDAFPWTISLHNFSIYTLLGKQ
VTLCLVEPMGCTSTLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDIMNKVWNKIQKRGNLNLSPTSPETMAGPV
PTSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEESPFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGTEVC
MVSELEDLSASIDVQDVYTKVKCKIESFNIDHYRSSLGEECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFSNCSGFFPSTTTKLLD
GTHQQHGFLSLTYTKAVTKNVRHKLTSRNERRSFHKLSEGLMDGSPHFLHEILLSAQAFDIVLYFPLLNAIASIFQAKLPKTQKEKRKSP
GQPMRTHTLTSRNLPLIYVNTSVIRIFIPKTEEMQPTVEANQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRDPGS
EIEDRQYQIDLQSINIGTAQWHQLKPEKESVSGGVVTETERNSQNPALEWNMASSIRRHQERRAILTPVLTDFSVRITGAPAVIFTKVVS
PENLHTEEILVCGHSLEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQKKVDIFDGGMAETSSRYSGAQDSGIGSDS
VKIRIVQIEQHSGASQHRIARPSRQSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKSQEQKNNEKTDKSSLNLPEVDSDVAKPNQA
CISTVTAEDLLRSSISFPSGKKIGVLSLESLHASTRSSARQALGITIVRQPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIF
DAVLKGVASDYKCIDPGKTLPEALDYCTVWLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFTKLDQINLFLKKI
KNAHSLAHSEETSAMSNTMVNKDDLPVSKYYRGKLSKPKIHGDGVQKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPCLLASL
SNLNGSLSVKATQKVPGIILGSSFLLSINDFLLKTSLKERSRILIGPCCATANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVFWGQE
HLNCLVLLHELLNGYLNEEGNFEVQVSEPVPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQDAESLKLPGVYEVLFYNETEDCPGMMLWR
YPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQVNISNYSLVMESDAGTFLPTGLQFTGSEKARAIMEEVMSLLQPLNITQVLSHGEG

--------------------------------------------------------------
>98269_98269_4_VPS13B-CPQ_VPS13B_chr8_100733275_ENST00000358544_CPQ_chr8_98078237_ENST00000220763_length(transcript)=7920nt_BP=7236nt
GGCGCGGTACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTCTTCCGAC
TTCGACTCCTTACCTTAAAAGATGCTGGAGTCATATGTAACTCCAATTTTAATGAGCTATGTGAATCGCTACATCAAGAACTTAAAGCCG
TCGGATCTACAGCTTTCACTATGGGGTGGAGACGTGGTACTCAGCAAGCTCGAGTTAAAGTTGGATGTGCTGGAACAGGAACTGAAATTA
CCATTCACTTTTTTAAGTGGACATATTCATGAATTGAGGATTCATGTACCATGGACAAAACTGGGTTCAGAACCAGTGGTAATTACCATC
AATACTATGGAATGCATTTTGAAACTTAAGGATGGGATACAGGATGACCATGAAAGCTGTGGTTCTAATTCTACCAACCGTAGTACTGCT
GAGAGCACAAAATCATCAATCAAACCGCGGAGAATGCAGCAGGCTGCTCCTACAGATCCTGACTTACCACCAGGTTATGTGCAGAGTCTG
ATTAGACGAGTTGTAAATAATGTAAACATTGTGATAAATAATCTCATACTAAAATATGTTGAAGATGATATCGTCCTTTCCGTCAATATC
ACTTCTGCAGAATGTTATACAGTAGGTGAATTATGGGATCGTGCATTCATGGATATTTCTGCAACTGATTTGGTGCTGAGAAAGGTTATC
AATTTTTCTGACTGTACAGTTTGTCTTGATAAACGGAATGCCAGTGGTAAAATAGAATTTTACCAGGATCCTTTATTATACAAATGTTCC
TTCAGAACTCGTCTTCATTTTACATATGAAAACCTAAATTCCAAGATGCCATCTGTTATTAAAATTCATACTTTAGTGGAAAGTTTGAAA
CTTTCTATCACAGATCAACAACTGCCTATGTTTATTCGTATAATGCAACTTGGAATTGCTCTTTACTATGGAGAAATAGGCAATTTTAAA
GAAGGCGAAATAGAGGACCTTACTTGTCATAATAAAGATATGCTAGGAAACATTACAGGTTCTGAAGATGAAACAAGAATAGATATGCAA
TATCCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAGCAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTG
CCTGCAATTGTGAGTTATGACGATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCACAGACTTTG
AAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACTTTCAAACTCACAGAAATGCAAGTTGAGAGTAGTTATTAC
AGTCCACAGAAAGTAAAATCTAAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAGGCCCTTATGATGGGAGAACCTTTCTTT
GATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAAAGGAATTATGGGTGTTAAAGATTTTGAAGAGAATATGAATAGAAGT
GAAACTGAAGCCTGTTTCTTCATTTGTGGTGACAATTTGAGTACGAAAGGTTTCACATACCTTACAAATTCATTGTTTGATTACCGAAGC
CCAGAAAATAATGGTACTCGCGCAGAATTTATCTTGGATTCAACTCATCATAAGGAGACATACACTGAGATAGCTGGAATGCAACGGTTT
GGGGCTTTTTATATGGATTACCTGTATACAATGGAGAACACTAGTGGCAAAGGTTCCACAAATCAACAAGACTTTTCTTCAGGGAAAAGT
GAAGATTTGGGAACAGTTCAGGAGAAGTCCACCAAAAGCCTTGTTATAGGTCCTCTTGATTTTCGTTTGGATAGCAGTGCGGTGCATAGG
ATTTTGAAAATGATTGTGTGTGCCTTGGAACATGAATATGAACCATATAGCAGGCTAAAATCAGATATTAAGGATGAAAATGAAACAATA
CTGAATCCTGAAGAGGTGGCTCTTCTGGAGGAATATATTCCTACTCGACATACAAGTGTTACTCTCCTCAAATGTACCTGCACAATTTCC
ATGGCTGAATTCAACTTGCTGGACCATTTACTACCTGTCATTATGGGAGAAAAGAACTCAAGTAACTTCATGAATACTACAAACTTCCAG
TCTCTTCGGCCTTTGCCATCCATTCGAATATTGGTGGATAAAATTAATCTGGAACATTCAGTGCCAATGTATGCTGAACAGTTGGTGCAT
GTGGTCAGCAGCCTTACTCAACCTTCTGATAACCTGCTTCATTATTGTTATGTACACTGCTATCTTAAGATATTTGGTTTCCAGGCAGGA
CTGACGTCTTTGGATTGCAGTGGATCTTACTGCTTACCTGTACCAGTTATTCCCTCTTTCAGCACTGCTCTTTATGGGAAACTTCTGAAA
CTCCCCACATGCTGGACCAAAAGATCTCAGATTGCTATAACTGAAGGTATATTTGAACTTCCAAATCTCACAATTCAAGCTACAAGAGCA
CAGACACTTCTCTTGCAAGCAATATATCAAAGTTGGTCTCATCTTGGAAATGTCAGCTCTTCCGCAGTGATTGAAGCTTTGATAAATGAA
ATCTTCCTAAGTATAGGTGTGAAATCTAAGAATCCCCTGCCAACTCTTGAGGGCTCAATCCAGAATGTTGAATTGAAGTACTGCAGCACA
TCATTGGTCAAATGTGCCTCTGGGACCATGGGATCAATAAAAATTTGTGCCAAAGCCCCAGTTGATAGTGGAAAAGAGAAGTTGATTCCC
TTGCTTCAGGGTCCTTCTGACACTAAAGACCTTCATAGCACCAAGTGGCTCAATGAGAGTAGAAAGCCAGAGTCTCTCTTAGCTCCAGAT
TTGATGGCCTTCACAATCCAAGTTCCACAATATATTGACTACTGCCACAATTCCGGTGCTGTACTTCTTTGCAGTATACAAGGACTAGCA
GTTAATATTGACCCAATCTTATATACGTGGCTCATCTATCAGCCTCAGAAACGAACAAGTAGACATATGCAACAGCAGCCTGTGGTAGCT
GTTCCTCTTGTTATGCCAGTTTGTAGAAGGAAAGAGGATGAGGTGTCTATTGGAAGTGCCCCCTTGGCAAAGCAGCAATCATATCAGGCC
TCTGAATATGCCAGCAGCCCTGTAAAAACAAAAACGGTAACAGAATCCCGCCCATTGTCAGTTCCTGTTAAAGCCATGTTGAATATATCT
GAAAGCTGTAGAAGTCCTGAAGAAAGAATGAAGGAATTTATTGGAATTGTTTGGAATGCAGTGAAGCATCTCACACTACAGCTTGAAGTA
CAATCTTGTTGTGTGTTTATTCCAAATGATAGCCTGCCTTCCCCAAGTACAATTGTATCTGGTGACATTCCTGGAACAGTAAGAAGTTGG
TACCATGGACAAACCAGCATGCCGGGAACACTTGTCCTCTGTTTGCCTCAAATAAAGATTATTAGTGCTGGGCACAAGTATATGGAACCT
CTGCAGGAGATTCCATTTGTTATCCCACGACCCATCCTTGAAGAAGGTGATGCTTTTCCTTGGACGATCAGCTTGCATAATTTCAGCATA
TATACCCTTCTTGGAAAACAAGTGACACTTTGCCTAGTGGAACCTATGGGTTGCACCTCCACTCTAGCTGTCACGTCTCAAAAACTGCTT
GCTACGGGACCTGATACACGACATTCATTTGTTGTCTGTCTCCATGTTGACCTAGAGTCACTAGAGATAAAATGCTCTAATCCCCAGGTC
CAGCTCTTCTATGAACTAACTGATATCATGAATAAGGTCTGGAACAAGATTCAGAAGAGAGGCAATCTCAACCTATCTCCAACCTCTCCA
GAGACCATGGCAGGGCCTGTTCCTACTTCTCCAGTTAGAAGCAGTATAGGCACAGCTCCTCCAGATACCAGCACATGCAGCCCATCTGCT
GACATTGGGACTACTACTGAGGGAGATTCTATACAAGCAGGTGAGGAATCACCATTCTCAGATTCTGTGACCTTGGAACAAACTACAAGT
AATATTGGAGGAACCAGTGGACGTGTTAGTTTATGGATGCAGTGGGTGCTTCCCAAAATTACTATAAAGCTCTTTGCTCCAGATCCTGAA
AATAAAGGCACAGAGGTTTGTATGGTCAGTGAACTAGAAGATCTCAGTGCTTCCATAGATGTCCAGGATGTATATACCAAAGTGAAATGT
AAAATAGAGAGTTTCAATATTGATCACTATAGAAGCAGCCTTGGGGAAGAGTGTTGGTCTTTGGGGCAATGTGGAGGTGTCTTCCTTTCC
TGTACTGACAAGCTGAACAGACGCACCTTGTTGGTTCGACCCATCAGCAAGCAGGACCCTTTCAGTAATTGCTCTGGCTTCTTTCCTTCT
ACAACTACAAAACTTCTAGATGGCACTCATCAGCAGCATGGATTCCTCTCTCTGACATACACAAAAGCTGTAACAAAAAATGTCCGCCAC
AAGTTAACATCAAGAAATGAGCGAAGAAGTTTTCATAAGTTATCTGAAGGCCTAATGGATGGTTCTCCTCATTTTCTTCATGAAATTCTT
CTTTCAGCACAAGCTTTTGATATTGTTCTTTATTTTCCTTTACTTAATGCCATTGCAAGTATATTTCAAGCAAAACTACCAAAGACCCAA
AAAGAGAAAAGAAAATCTCCTGGTCAGCCCATGAGGACCCATACACTGACATCCCGCAATTTACCTTTGATTTATGTCAACACAAGTGTA
ATCAGAATTTTTATTCCAAAAACAGAAGAAATGCAGCCAACTGTTGAAGCTAATCAGGCAGCAAAAGAAGACACTGTGGTTTTGAAGATT
GGCTCTGTTGCCATGGCTCCCCAGGCTGACAATCCCCTTGGCAGATCTGTCCTTAGGAAAGATATTTACCAGAGAGCCTTGAACTTAGGA
ATTCTTCGAGATCCTGGATCAGAAATCGAAGACAGACAATACCAAATAGATCTGCAGTCCATCAATATTGGTACTGCACAGTGGCATCAA
CTAAAACCAGAGAAGGAAAGTGTCTCAGGAGGGGTGGTAACAGAGACTGAAAGGAATTCTCAAAATCCAGCCCTTGAGTGGAATATGGCC
AGCAGCATACGGCGGCATCAAGAAAGGAGAGCAATTTTGACCCCCGTTTTGACAGATTTTTCTGTCCGAATAACTGGAGCACCTGCTGTC
ATTTTCACCAAAGTAGTTTCTCCAGAAAATTTGCATACTGAGGAGATTTTAGTGTGTGGCCATTCCTTAGAAGTGAATATAACCACAAAC
CTGGACTTCTTCCTAAGTGTGGCTCAAGTTCAACTCTTACATCAGTTAATAGTAGCAAATATGACTGGACTGGAACCATCAAACAAGGCT
GCAGAGATCTCTAAACAAGAACAGAAAAAAGTGGATATATTTGATGGAGGCATGGCTGAAACCTCATCTCGCTACAGTGGTGCTCAGGAT
AGTGGAATTGGCAGTGACAGTGTTAAAATCAGAATAGTGCAAATAGAGCAGCACAGTGGTGCCAGTCAGCATCGCATTGCCCGTCCCTCA
CGCCAGTCATCAATTGTAAAAAATCTAAATTTTATTCCCTTTGACATATTTATTACTGCAAGTAGAATCTCACTAATGACCTATTCCTGT
ATGGCCTTATCCAAATCGAAATCACAAGAACAGAAGAATAATGAAAAAACAGACAAGAGTTCATTAAATCTCCCAGAAGTTGATTCAGAT
GTTGCTAAGCCCAACCAGGCATGTATTTCCACGGTGACAGCAGAAGATCTCTTAAGGAGCAGCATTTCTTTTCCTTCAGGGAAAAAAATA
GGGGTCCTCTCTCTTGAAAGTCTTCATGCATCCACAAGGTCATCTGCTAGACAAGCACTTGGTATAACTATTGTTCGGCAGCCTGGTCGA
AGAGGAACTGGTGACTTACAGCTAGAGCCTTTTCTGTACTTTATTGTGTCCCAGCCTTCCTTGCTTCTGAGTTGTCACCACAGAAAGCAG
CGAGTGGAAGTATCCATTTTTGATGCTGTGCTTAAAGGGGTGGCCTCTGATTACAAATGTATAGATCCTGGGAAGACTCTGCCTGAAGCC
CTTGATTATTGCACTGTTTGGCTACAGACAGTGCCTGGAGAAATAGACAGCAAAAGTGGTATTCCACCTTCCTTTATAACACTACAGATT
AAAGACTTTCTGAATGGACCAGCGGATGTCAATTTGGATATATCAAAGCCTTTGAAAGCAAACCTGAGTTTCACCAAACTGGATCAGATA
AACCTTTTTTTAAAGAAGATAAAAAATGCACACAGTTTGGCACATAGTGAAGAGACTTCAGCCATGTCCAACACCATGGTGAATAAGGAT
GATCTTCCAGTCTCCAAATATTACCGTGGAAAGTTGTCTAAACCCAAAATTCATGGTGATGGAGTGCAAAAGATTTCAGCTCAAGAAAAC
ATGTGGAGAGCTGTTTCCTGCTTTCAAAAAATTTCTGTTCAAACTACTCAGATTGTGATCTCCATGGAAACTGTACCCCATACCAGCAAA
CCATGCCTGTTAGCATCTCTCTCAAACCTCAATGGAAGCCTTAGTGTCAAGGCAACACAAAAAGTACCTGGCATAATTCTTGGGTCATCA
TTTCTACTCAGTATAAACGATTTTCTCCTTAAAACAAGTCTCAAAGAAAGAAGCCGCATTCTGATAGGACCATGTTGTGCTACTGCCAAT
CTGGAAGCTAAGTGGTGTAAACACAGCGGGAATCCAGGCCCAGAACAATCCATACCAAAAATATCCATTGACTTAAGAGGAGGTCTACTA
CAGGTCTTCTGGGGTCAAGAACATTTGAATTGTTTAGTTCTTCTACATGAATTACTCAATGGATACCTTAATGAGGAGGGAAATTTTGAA
GTACAAGTTTCTGAACCAGTGCCTCAAATGTCATCTCCTGTGGAAAAGAATCAGACATTTAAAAGTGAACAAAGTTCAGATGACCTACGG
ACAGGTCTATTTCAGTATGTACAGGATGCTGAATCTTTGAAATTGCCTGGGGTCTATGAAGTCTTATTTTATAATGAAACTGAAGATTGC
CCAGGGATGATGTTATGGAGATATCCAGAACCTAGAGTACTCACCCTTGTACGAATAACTCCTGTACCTTTTAACACCACAGAGGATCCA
GATATTAGCACAGCAGACCTTGGTGATGTGCTACAGGTAAATATTTCCAACTACAGTCTGGTGATGGAGTCTGACGCAGGAACCTTCTTA
CCCACTGGGCTGCAATTCACTGGCAGTGAAAAGGCCAGGGCCATCATGGAGGAGGTTATGAGCCTGCTGCAGCCCCTCAATATCACTCAG
GTCCTGAGCCATGGAGAAGGGACAGACATCAACTTTTGGATCCAAGCTGGAGTGCCTGGAGCCAGTCTACTTGATGACTTATACAAGTAT
TTCTTCTTCCATCACTCCCACGGAGACACCATGACTGTCATGGATCCAAAGCAGATGAATGTTGCTGCTGCTGTTTGGGCTGTTGTTTCT
TATGTTGTTGCAGACATGGAAGAAATGCTGCCTAGGTCCTAGAAACAGTAAGAAAGAAACGTTTTCATGCTTCTGGCCAGGAATCCTGGG
TCTGCAACTTTGGAAAACTCCTCTTCACATAACAATTTCATCCAATTCATCTTCAAAGCACAACTCTATTTCATGCTTTCTGTTATTATC
TTTCTTGATACTTTCCAAATTCTCTGATTCTAGAAAAAGGAATCATTCTCCCCTCCCTCCCACCACATAGAATCAACATATGGTAGGGAT
TACAGTGGGGGCATTTCTTTATATCACCTCTTAAAAACATTGTTTCCACTTTAAAAGTAAACACTTAATAAATTTTTGGAAGATCTCTGA

>98269_98269_4_VPS13B-CPQ_VPS13B_chr8_100733275_ENST00000358544_CPQ_chr8_98078237_ENST00000220763_length(amino acids)=2496AA_BP=2375
MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELRIHVPWTKLGSEPVVITINTMECIL
KLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYT
VGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQ
LPMFIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQDEEQPQGWVSWAWSFVPAIVSYD
DGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRFGAFYMDY
LYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPEEVA
LLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQ
PSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLLLQA
IYQSWSHLGNVSSSAVIEALINEIFLSIGVKSKNPLPTLEGSIQNVELKYCSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSD
TKDLHSTKWLNESRKPESLLAPDLMAFTIQVPQYIDYCHNSGAVLLCSIQGLAVNIDPILYTWLIYQPQKRTSRHMQQQPVVAVPLVMPV
CRRKEDEVSIGSAPLAKQQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNISESCRSPEERMKEFIGIVWNAVKHLTLQLEVQSCCVFI
PNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISAGHKYMEPLQEIPFVIPRPILEEGDAFPWTISLHNFSIYTLLGKQ
VTLCLVEPMGCTSTLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDIMNKVWNKIQKRGNLNLSPTSPETMAGPV
PTSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEESPFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGTEVC
MVSELEDLSASIDVQDVYTKVKCKIESFNIDHYRSSLGEECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFSNCSGFFPSTTTKLLD
GTHQQHGFLSLTYTKAVTKNVRHKLTSRNERRSFHKLSEGLMDGSPHFLHEILLSAQAFDIVLYFPLLNAIASIFQAKLPKTQKEKRKSP
GQPMRTHTLTSRNLPLIYVNTSVIRIFIPKTEEMQPTVEANQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRDPGS
EIEDRQYQIDLQSINIGTAQWHQLKPEKESVSGGVVTETERNSQNPALEWNMASSIRRHQERRAILTPVLTDFSVRITGAPAVIFTKVVS
PENLHTEEILVCGHSLEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQKKVDIFDGGMAETSSRYSGAQDSGIGSDS
VKIRIVQIEQHSGASQHRIARPSRQSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKSQEQKNNEKTDKSSLNLPEVDSDVAKPNQA
CISTVTAEDLLRSSISFPSGKKIGVLSLESLHASTRSSARQALGITIVRQPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIF
DAVLKGVASDYKCIDPGKTLPEALDYCTVWLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFTKLDQINLFLKKI
KNAHSLAHSEETSAMSNTMVNKDDLPVSKYYRGKLSKPKIHGDGVQKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPCLLASL
SNLNGSLSVKATQKVPGIILGSSFLLSINDFLLKTSLKERSRILIGPCCATANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVFWGQE
HLNCLVLLHELLNGYLNEEGNFEVQVSEPVPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQDAESLKLPGVYEVLFYNETEDCPGMMLWR
YPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQVNISNYSLVMESDAGTFLPTGLQFTGSEKARAIMEEVMSLLQPLNITQVLSHGEG

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Top

Fusion Gene PPI Analysis for VPS13B-CPQ

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for VPS13B-CPQ

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for VPS13B-CPQ

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source