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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:VPS13B-RAD54B (FusionGDB2 ID:98288)

Fusion Gene Summary for VPS13B-RAD54B

Fusion gene summary

Fusion gene information	Fusion gene name: VPS13B-RAD54B
	Fusion gene ID: 98288
		Hgene	Tgene
	Gene symbol	VPS13B	RAD54B
	Gene ID	157680	25788
	Gene name	vacuolar protein sorting 13 homolog B	RAD54 homolog B
	Synonyms	CHS1\|COH1	RDH54
	Cytomap	8q22.2	8q22.1
	Type of gene	protein-coding	protein-coding
	Description	vacuolar protein sorting-associated protein 13B	DNA repair and recombination protein RAD54B
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000521932, ENST00000355155, ENST00000357162, ENST00000358544, ENST00000395996, ENST00000441350,	ENST00000336148, ENST00000297592, ENST00000519348,
Fusion gene scores	* DoF score	43 X 36 X 17=26316	6 X 4 X 5=120
	# samples	50	6
	** MAII score	log2(50/26316*10)=-5.71786831273266 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: VPS13B [Title/Abstract] AND RAD54B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	VPS13B(100205285)-RAD54B(95423543), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RAD54B	GO:0000724	double-strand break repair via homologous recombination	16428451

Fusion gene breakpoints across VPS13B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAD54B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-LN-A4A2	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-

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Fusion Gene ORF analysis for VPS13B-RAD54B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000521932	ENST00000336148	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
3UTR-intron	ENST00000521932	ENST00000297592	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
3UTR-intron	ENST00000521932	ENST00000519348	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
5CDS-intron	ENST00000355155	ENST00000297592	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
5CDS-intron	ENST00000355155	ENST00000519348	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
5CDS-intron	ENST00000357162	ENST00000297592	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
5CDS-intron	ENST00000357162	ENST00000519348	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
5CDS-intron	ENST00000358544	ENST00000297592	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
5CDS-intron	ENST00000358544	ENST00000519348	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
5CDS-intron	ENST00000395996	ENST00000297592	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
5CDS-intron	ENST00000395996	ENST00000519348	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
In-frame	ENST00000355155	ENST00000336148	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
In-frame	ENST00000357162	ENST00000336148	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
In-frame	ENST00000358544	ENST00000336148	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
In-frame	ENST00000395996	ENST00000336148	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
intron-3CDS	ENST00000441350	ENST00000336148	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
intron-intron	ENST00000441350	ENST00000297592	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-
intron-intron	ENST00000441350	ENST00000519348	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000395996	VPS13B	chr8	100205285	+	ENST00000336148	RAD54B	chr8	95423543	-	5265	2626	111	5054	1647
ENST00000358544	VPS13B	chr8	100205285	+	ENST00000336148	RAD54B	chr8	95423543	-	5265	2626	111	5054	1647
ENST00000357162	VPS13B	chr8	100205285	+	ENST00000336148	RAD54B	chr8	95423543	-	5265	2626	111	5054	1647
ENST00000355155	VPS13B	chr8	100205285	+	ENST00000336148	RAD54B	chr8	95423543	-	5265	2626	111	5054	1647

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000395996	ENST00000336148	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-	0.000107102	0.99989283
ENST00000358544	ENST00000336148	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-	0.000107102	0.99989283
ENST00000357162	ENST00000336148	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-	0.000107102	0.99989283
ENST00000355155	ENST00000336148	VPS13B	chr8	100205285	+	RAD54B	chr8	95423543	-	0.000107102	0.99989283

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Fusion Genomic Features for VPS13B-RAD54B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VPS13B-RAD54B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:100205285/chr8:95423543)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RAD54B

chr8:100205285

chr8:95423543

ENST00000297592

313_480

118.0

Domain

Helicase ATP-binding

Tgene

RAD54B

chr8:100205285

chr8:95423543

ENST00000297592

649_810

118.0

Domain

Helicase C-terminal

Tgene

RAD54B

chr8:100205285

chr8:95423543

ENST00000336148

313_480

101

911.0

Domain

Helicase ATP-binding

Tgene

RAD54B

chr8:100205285

chr8:95423543

ENST00000336148

649_810

101

911.0

Domain

Helicase C-terminal

Tgene

RAD54B

chr8:100205285

chr8:95423543

ENST00000297592

431_434

118.0

Motif

Note=DEGH box

Tgene

RAD54B

chr8:100205285

chr8:95423543

ENST00000336148

431_434

101

911.0

Motif

Note=DEGH box

Tgene

RAD54B

chr8:100205285

chr8:95423543

ENST00000297592

326_333

118.0

Nucleotide binding

ATP

Tgene

RAD54B

chr8:100205285

chr8:95423543

ENST00000336148

326_333

101

911.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for VPS13B-RAD54B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>98288_98288_1_VPS13B-RAD54B_VPS13B_chr8_100205285_ENST00000355155_RAD54B_chr8_95423543_ENST00000336148_length(transcript)=5265nt_BP=2626nt
GGCGCGGTACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTCTTCCGAC
TTCGACTCCTTACCTTAAAAGATGCTGGAGTCATATGTAACTCCAATTTTAATGAGCTATGTGAATCGCTACATCAAGAACTTAAAGCCG
TCGGATCTACAGCTTTCACTATGGGGTGGAGACGTGGTACTCAGCAAGCTCGAGTTAAAGTTGGATGTGCTGGAACAGGAACTGAAATTA
CCATTCACTTTTTTAAGTGGACATATTCATGAATTGAGGATTCATGTACCATGGACAAAACTGGGTTCAGAACCAGTGGTAATTACCATC
AATACTATGGAATGCATTTTGAAACTTAAGGATGGGATACAGGATGACCATGAAAGCTGTGGTTCTAATTCTACCAACCGTAGTACTGCT
GAGAGCACAAAATCATCAATCAAACCGCGGAGAATGCAGCAGGCTGCTCCTACAGATCCTGACTTACCACCAGGTTATGTGCAGAGTCTG
ATTAGACGAGTTGTAAATAATGTAAACATTGTGATAAATAATCTCATACTAAAATATGTTGAAGATGATATCGTCCTTTCCGTCAATATC
ACTTCTGCAGAATGTTATACAGTAGGTGAATTATGGGATCGTGCATTCATGGATATTTCTGCAACTGATTTGGTGCTGAGAAAGGTTATC
AATTTTTCTGACTGTACAGTTTGTCTTGATAAACGGAATGCCAGTGGTAAAATAGAATTTTACCAGGATCCTTTATTATACAAATGTTCC
TTCAGAACTCGTCTTCATTTTACATATGAAAACCTAAATTCCAAGATGCCATCTGTTATTAAAATTCATACTTTAGTGGAAAGTTTGAAA
CTTTCTATCACAGATCAACAACTGCCTATGTTTATTCGTATAATGCAACTTGGAATTGCTCTTTACTATGGAGAAATAGGCAATTTTAAA
GAAGGCGAAATAGAGGACCTTACTTGTCATAATAAAGATATGCTAGGAAACATTACAGGTTCTGAAGATGAAACAAGAATAGATATGCAA
TATCCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAGCAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTG
CCTGCAATTGTGAGTTATGACGATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCACAGACTTTG
AAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACTTTCAAACTCACAGAAATGCAAGTTGAGAGTAGTTATTAC
AGTCCACAGAAAGTAAAATCTAAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAGGCCCTTATGATGGGAGAACCTTTCTTT
GATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAAAGGAATTATGGGTGTTAAAGATTTTGAAGAGAATATGAATAGAAGT
GAAACTGAAGCCTGTTTCTTCATTTGTGGTGACAATTTGAGTACGAAAGGTTTCACATACCTTACAAATTCATTGTTTGATTACCGAAGC
CCAGAAAATAATGGTACTCGCGCAGAATTTATCTTGGATTCAACTCATCATAAGGAGACATACACTGAGATAGCTGGAATGCAACGGTTT
GGGGCTTTTTATATGGATTACCTGTATACAATGGAGAACACTAGTGGCAAAGGTTCCACAAATCAACAAGACTTTTCTTCAGGGAAAAGT
GAAGATTTGGGAACAGTTCAGGAGAAGTCCACCAAAAGCCTTGTTATAGGTCCTCTTGATTTTCGTTTGGATAGCAGTGCGGTGCATAGG
ATTTTGAAAATGATTGTGTGTGCCTTGGAACATGAATATGAACCATATAGCAGGCTAAAATCAGATATTAAGGATGAAAATGAAACAATA
CTGAATCCTGAAGAGGTGGCTCTTCTGGAGGAATATATTCCTACTCGACATACAAGTGTTACTCTCCTCAAATGTACCTGCACAATTTCC
ATGGCTGAATTCAACTTGCTGGACCATTTACTACCTGTCATTATGGGAGAAAAGAACTCAAGTAACTTCATGAATACTACAAACTTCCAG
TCTCTTCGGCCTTTGCCATCCATTCGAATATTGGTGGATAAAATTAATCTGGAACATTCAGTGCCAATGTATGCTGAACAGTTGGTGCAT
GTGGTCAGCAGCCTTACTCAACCTTCTGATAACCTGCTTCATTATTGTTATGTACACTGCTATCTTAAGATATTTGGTTTCCAGGCAGGA
CTGACGTCTTTGGATTGCAGTGGATCTTACTGCTTACCTGTACCAGTTATTCCCTCTTTCAGCACTGCTCTTTATGGGAAACTTCTGAAA
CTCCCCACATGCTGGACCAAAAGATCTCAGATTGCTATAACTGAAGGTATATTTGAACTTCCAAATCTCACAATTCAAGCTACAAGAGCA
CAGACACTTCTCTTGCAAGCAATATATCAAAGTTGGTCTCATCTTGGAAATGTCAGCTCTTCCGCAGTGATTGAAGCTTTGATAAATGAA
ATCTTCCTAAGTATAGTTCATTCGGCTCCTAAAGAAGTAGCAGTGTCCAAGGAACAAGAAGAGAAATCTGATAGCCTAGTTAAATATTTC
AGTGTTGTTTGGTGTAAGCCTTCAAAGAAAAAACATAAAAAGTGGGAAGGTGATGCTGTTCTTATTGTAAAAGGAAAGTCATTTATATTA
AAGAATTTGGAAGGCAAAGACATTGGAAGAGGCATTGGTTATAAATTCAAAGAGCTTGAAAAGATTGAAGAGGGCCAAACACTGATGATT
TGTGGAAAAGAAATAGAAGTCATGGGTGTAATCTCTCCAGATGACTTCAGCAGTGGCAGGTGTTTTCAGCTTGGAGGAGGAAGTACTGCT
ATCTCGCATTCTTCTCAGGTTGCCAGGAAATGTTTCTCTAACCCTTTCAAAAGTGTTTGTAAACCAAGTTCAAAGGAAAATAGACAGAAT
GATTTCCAAAATTGCAAACCACGCCATGACCCATATACGCCAAATTCCCTCGTTATGCCACGACCAGATAAGAATCACCAGTGGGTATTC
AATAAGAACTGTTTCCCTCTTGTGGATGTAGTGATTGATCCTTACCTTGTATATCATCTTCGACCACATCAGAAAGAAGGAATCATATTC
CTTTATGAATGTGTAATGGGAATGAGAATGAATGGCAGATGTGGAGCTATTCTTGCTGATGAAATGGGTTTAGGGAAGACATTGCAATGT
ATTTCGCTCATCTGGACCCTGCAGTGTCAGGGACCCTATGGAGGCAAGCCAGTAATAAAGAAGACACTAATTGTCACACCTGGAAGCTTG
GTGAATAATTGGAAGAAAGAATTTCAAAAATGGCTAGGAAGTGAAAGGATCAAGATATTTACTGTTGATCAGGACCACAAAGTTGAAGAA
TTCATCAAGTCTATATTTTATTCTGTTCTTATTATCAGTTATGAAATGTTACTTCGTTCCCTGGATCAAATTAAGAATATAAAATTTGAT
CTTCTAATCTGTGACGAGGGGCATCGTTTGAAGAACAGTGCCATTAAGACAACTACAGCCCTCATTAGCCTTTCTTGTGAGAAAAGAATA
ATTCTAACTGGTACTCCAATTCAGAATGATCTGCAAGAATTTTTTGCATTAATTGATTTTGTAAATCCAGGAATATTAGGCTCTTTGTCA
TCTTATAGGAAAATATATGAAGAACCCATCATTTTATCGAGAGAACCTTCTGCTTCTGAGGAAGAAAAGGAGTTAGGAGAAAGAAGAGCA
GCTGAACTTACTTGCCTCACTGGACTCTTTATCCTTAGAAGAACCCAAGAAATTATAAATAAATATCTCCCACCTAAAATAGAGAATGTT
GTCTTTTGCCGACCAGGAGCACTACAGATTGAGCTTTATCGAAAGCTGTTAAATTCTCAGGTTGTCAGGTTCTGCCTTCAAGGGTTGTTG
GAAAATAGTCCCCATCTAATATGTATAGGAGCTCTTAAAAAACTGTGCAATCACCCCTGCCTTTTGTTCAACTCTATAAAGGAAAAGGAA
TGTAGCTCAACTTGTGATAAAAATGAAGAAAAGAGTCTATACAAAGGCTTGCTAAGTGTGTTTCCTGCTGACTACAACCCTCTCCTGTTT
ACTGAAAAGGAGTCAGGAAAACTACAGGTGTTGTCCAAGCTCTTAGCGGTTATCCACGAACTTCGACCTACTGAAAAGGTGGTGTTGGTA
TCCAACTATACACAAACCTTGAACATTTTACAAGAAGTATGTAAGCGTCATGGATATGCTTATACAAGACTTGATGGACAAACACCAATC
TCTCAAAGGCAGCAGATTGTTGATGGCTTTAACAGTCAACACTCTTCTTTTTTTATTTTTTTGTTAAGTTCAAAAGCTGGTGGTGTAGGA
CTTAACCTCATTGGAGGATCTCACTTAATTCTCTATGACATTGATTGGAATCCAGCCACTGACATTCAGGCAATGTCTAGAGTATGGAGA
GATGGTCAGAAATATCCTGTACATATTTACAGACTCCTAACTACAGGTACAATAGAAGAAAAGATCTATCAAAGGCAGATCAGTAAGCAA
GGTCTTTGTGGGGCAGTTGTCGACCTCACCAAGACATCTGAACATATTCAGTTTTCAGTAGAAGAACTTAAAAATTTGTTCACATTACAT
GAAAGTTCAGATTGTGTTACTCATGATCTGCTTGACTGTGAGTGTACAGGAGAAGAAGTTCATACAGGTGATTCGTTGGAAAAATTCATT
GTCTCTAGAGATTGTCAGCTTGGTCCACATCACCAGAAATCTAACTCCCTGAAACCTCTTTCTATGTCCCAGCTGAAGCAATGGAAACAT
TTTTCTGGAGATCATTTAAATCTTACAGATCCTTTTCTTGAAAGAATAACAGAAAATGTGTCATTCATTTTTCAGAATATAACCACTCAA
GCTACTGGCACATAGTGAAAGATTACTTCTGACATTCCATTGCTCTTCTTTTGAAAATTAGTATGGTAATTAAATGTACTTTTTGAAAAT
TAATAGAATTATTTAAATTACAGTATATGTTGCAAAATATATCACTTTTGATACAATAGTCAAAATTGAGTGGTTTAATGTTTTGTAAAT

>98288_98288_1_VPS13B-RAD54B_VPS13B_chr8_100205285_ENST00000355155_RAD54B_chr8_95423543_ENST00000336148_length(amino acids)=1647AA_BP=834
MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELRIHVPWTKLGSEPVVITINTMECIL
KLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYT
VGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQ
LPMFIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQDEEQPQGWVSWAWSFVPAIVSYD
DGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRFGAFYMDY
LYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPEEVA
LLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQ
PSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLLLQA
IYQSWSHLGNVSSSAVIEALINEIFLSIVHSAPKEVAVSKEQEEKSDSLVKYFSVVWCKPSKKKHKKWEGDAVLIVKGKSFILKNLEGKD
IGRGIGYKFKELEKIEEGQTLMICGKEIEVMGVISPDDFSSGRCFQLGGGSTAISHSSQVARKCFSNPFKSVCKPSSKENRQNDFQNCKP
RHDPYTPNSLVMPRPDKNHQWVFNKNCFPLVDVVIDPYLVYHLRPHQKEGIIFLYECVMGMRMNGRCGAILADEMGLGKTLQCISLIWTL
QCQGPYGGKPVIKKTLIVTPGSLVNNWKKEFQKWLGSERIKIFTVDQDHKVEEFIKSIFYSVLIISYEMLLRSLDQIKNIKFDLLICDEG
HRLKNSAIKTTTALISLSCEKRIILTGTPIQNDLQEFFALIDFVNPGILGSLSSYRKIYEEPIILSREPSASEEEKELGERRAAELTCLT
GLFILRRTQEIINKYLPPKIENVVFCRPGALQIELYRKLLNSQVVRFCLQGLLENSPHLICIGALKKLCNHPCLLFNSIKEKECSSTCDK
NEEKSLYKGLLSVFPADYNPLLFTEKESGKLQVLSKLLAVIHELRPTEKVVLVSNYTQTLNILQEVCKRHGYAYTRLDGQTPISQRQQIV
DGFNSQHSSFFIFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKYPVHIYRLLTTGTIEEKIYQRQISKQGLCGAVV
DLTKTSEHIQFSVEELKNLFTLHESSDCVTHDLLDCECTGEEVHTGDSLEKFIVSRDCQLGPHHQKSNSLKPLSMSQLKQWKHFSGDHLN

--------------------------------------------------------------
>98288_98288_2_VPS13B-RAD54B_VPS13B_chr8_100205285_ENST00000357162_RAD54B_chr8_95423543_ENST00000336148_length(transcript)=5265nt_BP=2626nt
GGCGCGGTACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTCTTCCGAC
TTCGACTCCTTACCTTAAAAGATGCTGGAGTCATATGTAACTCCAATTTTAATGAGCTATGTGAATCGCTACATCAAGAACTTAAAGCCG
TCGGATCTACAGCTTTCACTATGGGGTGGAGACGTGGTACTCAGCAAGCTCGAGTTAAAGTTGGATGTGCTGGAACAGGAACTGAAATTA
CCATTCACTTTTTTAAGTGGACATATTCATGAATTGAGGATTCATGTACCATGGACAAAACTGGGTTCAGAACCAGTGGTAATTACCATC
AATACTATGGAATGCATTTTGAAACTTAAGGATGGGATACAGGATGACCATGAAAGCTGTGGTTCTAATTCTACCAACCGTAGTACTGCT
GAGAGCACAAAATCATCAATCAAACCGCGGAGAATGCAGCAGGCTGCTCCTACAGATCCTGACTTACCACCAGGTTATGTGCAGAGTCTG
ATTAGACGAGTTGTAAATAATGTAAACATTGTGATAAATAATCTCATACTAAAATATGTTGAAGATGATATCGTCCTTTCCGTCAATATC
ACTTCTGCAGAATGTTATACAGTAGGTGAATTATGGGATCGTGCATTCATGGATATTTCTGCAACTGATTTGGTGCTGAGAAAGGTTATC
AATTTTTCTGACTGTACAGTTTGTCTTGATAAACGGAATGCCAGTGGTAAAATAGAATTTTACCAGGATCCTTTATTATACAAATGTTCC
TTCAGAACTCGTCTTCATTTTACATATGAAAACCTAAATTCCAAGATGCCATCTGTTATTAAAATTCATACTTTAGTGGAAAGTTTGAAA
CTTTCTATCACAGATCAACAACTGCCTATGTTTATTCGTATAATGCAACTTGGAATTGCTCTTTACTATGGAGAAATAGGCAATTTTAAA
GAAGGCGAAATAGAGGACCTTACTTGTCATAATAAAGATATGCTAGGAAACATTACAGGTTCTGAAGATGAAACAAGAATAGATATGCAA
TATCCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAGCAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTG
CCTGCAATTGTGAGTTATGACGATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCACAGACTTTG
AAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACTTTCAAACTCACAGAAATGCAAGTTGAGAGTAGTTATTAC
AGTCCACAGAAAGTAAAATCTAAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAGGCCCTTATGATGGGAGAACCTTTCTTT
GATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAAAGGAATTATGGGTGTTAAAGATTTTGAAGAGAATATGAATAGAAGT
GAAACTGAAGCCTGTTTCTTCATTTGTGGTGACAATTTGAGTACGAAAGGTTTCACATACCTTACAAATTCATTGTTTGATTACCGAAGC
CCAGAAAATAATGGTACTCGCGCAGAATTTATCTTGGATTCAACTCATCATAAGGAGACATACACTGAGATAGCTGGAATGCAACGGTTT
GGGGCTTTTTATATGGATTACCTGTATACAATGGAGAACACTAGTGGCAAAGGTTCCACAAATCAACAAGACTTTTCTTCAGGGAAAAGT
GAAGATTTGGGAACAGTTCAGGAGAAGTCCACCAAAAGCCTTGTTATAGGTCCTCTTGATTTTCGTTTGGATAGCAGTGCGGTGCATAGG
ATTTTGAAAATGATTGTGTGTGCCTTGGAACATGAATATGAACCATATAGCAGGCTAAAATCAGATATTAAGGATGAAAATGAAACAATA
CTGAATCCTGAAGAGGTGGCTCTTCTGGAGGAATATATTCCTACTCGACATACAAGTGTTACTCTCCTCAAATGTACCTGCACAATTTCC
ATGGCTGAATTCAACTTGCTGGACCATTTACTACCTGTCATTATGGGAGAAAAGAACTCAAGTAACTTCATGAATACTACAAACTTCCAG
TCTCTTCGGCCTTTGCCATCCATTCGAATATTGGTGGATAAAATTAATCTGGAACATTCAGTGCCAATGTATGCTGAACAGTTGGTGCAT
GTGGTCAGCAGCCTTACTCAACCTTCTGATAACCTGCTTCATTATTGTTATGTACACTGCTATCTTAAGATATTTGGTTTCCAGGCAGGA
CTGACGTCTTTGGATTGCAGTGGATCTTACTGCTTACCTGTACCAGTTATTCCCTCTTTCAGCACTGCTCTTTATGGGAAACTTCTGAAA
CTCCCCACATGCTGGACCAAAAGATCTCAGATTGCTATAACTGAAGGTATATTTGAACTTCCAAATCTCACAATTCAAGCTACAAGAGCA
CAGACACTTCTCTTGCAAGCAATATATCAAAGTTGGTCTCATCTTGGAAATGTCAGCTCTTCCGCAGTGATTGAAGCTTTGATAAATGAA
ATCTTCCTAAGTATAGTTCATTCGGCTCCTAAAGAAGTAGCAGTGTCCAAGGAACAAGAAGAGAAATCTGATAGCCTAGTTAAATATTTC
AGTGTTGTTTGGTGTAAGCCTTCAAAGAAAAAACATAAAAAGTGGGAAGGTGATGCTGTTCTTATTGTAAAAGGAAAGTCATTTATATTA
AAGAATTTGGAAGGCAAAGACATTGGAAGAGGCATTGGTTATAAATTCAAAGAGCTTGAAAAGATTGAAGAGGGCCAAACACTGATGATT
TGTGGAAAAGAAATAGAAGTCATGGGTGTAATCTCTCCAGATGACTTCAGCAGTGGCAGGTGTTTTCAGCTTGGAGGAGGAAGTACTGCT
ATCTCGCATTCTTCTCAGGTTGCCAGGAAATGTTTCTCTAACCCTTTCAAAAGTGTTTGTAAACCAAGTTCAAAGGAAAATAGACAGAAT
GATTTCCAAAATTGCAAACCACGCCATGACCCATATACGCCAAATTCCCTCGTTATGCCACGACCAGATAAGAATCACCAGTGGGTATTC
AATAAGAACTGTTTCCCTCTTGTGGATGTAGTGATTGATCCTTACCTTGTATATCATCTTCGACCACATCAGAAAGAAGGAATCATATTC
CTTTATGAATGTGTAATGGGAATGAGAATGAATGGCAGATGTGGAGCTATTCTTGCTGATGAAATGGGTTTAGGGAAGACATTGCAATGT
ATTTCGCTCATCTGGACCCTGCAGTGTCAGGGACCCTATGGAGGCAAGCCAGTAATAAAGAAGACACTAATTGTCACACCTGGAAGCTTG
GTGAATAATTGGAAGAAAGAATTTCAAAAATGGCTAGGAAGTGAAAGGATCAAGATATTTACTGTTGATCAGGACCACAAAGTTGAAGAA
TTCATCAAGTCTATATTTTATTCTGTTCTTATTATCAGTTATGAAATGTTACTTCGTTCCCTGGATCAAATTAAGAATATAAAATTTGAT
CTTCTAATCTGTGACGAGGGGCATCGTTTGAAGAACAGTGCCATTAAGACAACTACAGCCCTCATTAGCCTTTCTTGTGAGAAAAGAATA
ATTCTAACTGGTACTCCAATTCAGAATGATCTGCAAGAATTTTTTGCATTAATTGATTTTGTAAATCCAGGAATATTAGGCTCTTTGTCA
TCTTATAGGAAAATATATGAAGAACCCATCATTTTATCGAGAGAACCTTCTGCTTCTGAGGAAGAAAAGGAGTTAGGAGAAAGAAGAGCA
GCTGAACTTACTTGCCTCACTGGACTCTTTATCCTTAGAAGAACCCAAGAAATTATAAATAAATATCTCCCACCTAAAATAGAGAATGTT
GTCTTTTGCCGACCAGGAGCACTACAGATTGAGCTTTATCGAAAGCTGTTAAATTCTCAGGTTGTCAGGTTCTGCCTTCAAGGGTTGTTG
GAAAATAGTCCCCATCTAATATGTATAGGAGCTCTTAAAAAACTGTGCAATCACCCCTGCCTTTTGTTCAACTCTATAAAGGAAAAGGAA
TGTAGCTCAACTTGTGATAAAAATGAAGAAAAGAGTCTATACAAAGGCTTGCTAAGTGTGTTTCCTGCTGACTACAACCCTCTCCTGTTT
ACTGAAAAGGAGTCAGGAAAACTACAGGTGTTGTCCAAGCTCTTAGCGGTTATCCACGAACTTCGACCTACTGAAAAGGTGGTGTTGGTA
TCCAACTATACACAAACCTTGAACATTTTACAAGAAGTATGTAAGCGTCATGGATATGCTTATACAAGACTTGATGGACAAACACCAATC
TCTCAAAGGCAGCAGATTGTTGATGGCTTTAACAGTCAACACTCTTCTTTTTTTATTTTTTTGTTAAGTTCAAAAGCTGGTGGTGTAGGA
CTTAACCTCATTGGAGGATCTCACTTAATTCTCTATGACATTGATTGGAATCCAGCCACTGACATTCAGGCAATGTCTAGAGTATGGAGA
GATGGTCAGAAATATCCTGTACATATTTACAGACTCCTAACTACAGGTACAATAGAAGAAAAGATCTATCAAAGGCAGATCAGTAAGCAA
GGTCTTTGTGGGGCAGTTGTCGACCTCACCAAGACATCTGAACATATTCAGTTTTCAGTAGAAGAACTTAAAAATTTGTTCACATTACAT
GAAAGTTCAGATTGTGTTACTCATGATCTGCTTGACTGTGAGTGTACAGGAGAAGAAGTTCATACAGGTGATTCGTTGGAAAAATTCATT
GTCTCTAGAGATTGTCAGCTTGGTCCACATCACCAGAAATCTAACTCCCTGAAACCTCTTTCTATGTCCCAGCTGAAGCAATGGAAACAT
TTTTCTGGAGATCATTTAAATCTTACAGATCCTTTTCTTGAAAGAATAACAGAAAATGTGTCATTCATTTTTCAGAATATAACCACTCAA
GCTACTGGCACATAGTGAAAGATTACTTCTGACATTCCATTGCTCTTCTTTTGAAAATTAGTATGGTAATTAAATGTACTTTTTGAAAAT
TAATAGAATTATTTAAATTACAGTATATGTTGCAAAATATATCACTTTTGATACAATAGTCAAAATTGAGTGGTTTAATGTTTTGTAAAT

>98288_98288_2_VPS13B-RAD54B_VPS13B_chr8_100205285_ENST00000357162_RAD54B_chr8_95423543_ENST00000336148_length(amino acids)=1647AA_BP=834
MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELRIHVPWTKLGSEPVVITINTMECIL
KLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYT
VGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQ
LPMFIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQDEEQPQGWVSWAWSFVPAIVSYD
DGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRFGAFYMDY
LYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPEEVA
LLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQ
PSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLLLQA
IYQSWSHLGNVSSSAVIEALINEIFLSIVHSAPKEVAVSKEQEEKSDSLVKYFSVVWCKPSKKKHKKWEGDAVLIVKGKSFILKNLEGKD
IGRGIGYKFKELEKIEEGQTLMICGKEIEVMGVISPDDFSSGRCFQLGGGSTAISHSSQVARKCFSNPFKSVCKPSSKENRQNDFQNCKP
RHDPYTPNSLVMPRPDKNHQWVFNKNCFPLVDVVIDPYLVYHLRPHQKEGIIFLYECVMGMRMNGRCGAILADEMGLGKTLQCISLIWTL
QCQGPYGGKPVIKKTLIVTPGSLVNNWKKEFQKWLGSERIKIFTVDQDHKVEEFIKSIFYSVLIISYEMLLRSLDQIKNIKFDLLICDEG
HRLKNSAIKTTTALISLSCEKRIILTGTPIQNDLQEFFALIDFVNPGILGSLSSYRKIYEEPIILSREPSASEEEKELGERRAAELTCLT
GLFILRRTQEIINKYLPPKIENVVFCRPGALQIELYRKLLNSQVVRFCLQGLLENSPHLICIGALKKLCNHPCLLFNSIKEKECSSTCDK
NEEKSLYKGLLSVFPADYNPLLFTEKESGKLQVLSKLLAVIHELRPTEKVVLVSNYTQTLNILQEVCKRHGYAYTRLDGQTPISQRQQIV
DGFNSQHSSFFIFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKYPVHIYRLLTTGTIEEKIYQRQISKQGLCGAVV
DLTKTSEHIQFSVEELKNLFTLHESSDCVTHDLLDCECTGEEVHTGDSLEKFIVSRDCQLGPHHQKSNSLKPLSMSQLKQWKHFSGDHLN

--------------------------------------------------------------
>98288_98288_3_VPS13B-RAD54B_VPS13B_chr8_100205285_ENST00000358544_RAD54B_chr8_95423543_ENST00000336148_length(transcript)=5265nt_BP=2626nt
GGCGCGGTACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTCTTCCGAC
TTCGACTCCTTACCTTAAAAGATGCTGGAGTCATATGTAACTCCAATTTTAATGAGCTATGTGAATCGCTACATCAAGAACTTAAAGCCG
TCGGATCTACAGCTTTCACTATGGGGTGGAGACGTGGTACTCAGCAAGCTCGAGTTAAAGTTGGATGTGCTGGAACAGGAACTGAAATTA
CCATTCACTTTTTTAAGTGGACATATTCATGAATTGAGGATTCATGTACCATGGACAAAACTGGGTTCAGAACCAGTGGTAATTACCATC
AATACTATGGAATGCATTTTGAAACTTAAGGATGGGATACAGGATGACCATGAAAGCTGTGGTTCTAATTCTACCAACCGTAGTACTGCT
GAGAGCACAAAATCATCAATCAAACCGCGGAGAATGCAGCAGGCTGCTCCTACAGATCCTGACTTACCACCAGGTTATGTGCAGAGTCTG
ATTAGACGAGTTGTAAATAATGTAAACATTGTGATAAATAATCTCATACTAAAATATGTTGAAGATGATATCGTCCTTTCCGTCAATATC
ACTTCTGCAGAATGTTATACAGTAGGTGAATTATGGGATCGTGCATTCATGGATATTTCTGCAACTGATTTGGTGCTGAGAAAGGTTATC
AATTTTTCTGACTGTACAGTTTGTCTTGATAAACGGAATGCCAGTGGTAAAATAGAATTTTACCAGGATCCTTTATTATACAAATGTTCC
TTCAGAACTCGTCTTCATTTTACATATGAAAACCTAAATTCCAAGATGCCATCTGTTATTAAAATTCATACTTTAGTGGAAAGTTTGAAA
CTTTCTATCACAGATCAACAACTGCCTATGTTTATTCGTATAATGCAACTTGGAATTGCTCTTTACTATGGAGAAATAGGCAATTTTAAA
GAAGGCGAAATAGAGGACCTTACTTGTCATAATAAAGATATGCTAGGAAACATTACAGGTTCTGAAGATGAAACAAGAATAGATATGCAA
TATCCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAGCAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTG
CCTGCAATTGTGAGTTATGACGATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCACAGACTTTG
AAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACTTTCAAACTCACAGAAATGCAAGTTGAGAGTAGTTATTAC
AGTCCACAGAAAGTAAAATCTAAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAGGCCCTTATGATGGGAGAACCTTTCTTT
GATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAAAGGAATTATGGGTGTTAAAGATTTTGAAGAGAATATGAATAGAAGT
GAAACTGAAGCCTGTTTCTTCATTTGTGGTGACAATTTGAGTACGAAAGGTTTCACATACCTTACAAATTCATTGTTTGATTACCGAAGC
CCAGAAAATAATGGTACTCGCGCAGAATTTATCTTGGATTCAACTCATCATAAGGAGACATACACTGAGATAGCTGGAATGCAACGGTTT
GGGGCTTTTTATATGGATTACCTGTATACAATGGAGAACACTAGTGGCAAAGGTTCCACAAATCAACAAGACTTTTCTTCAGGGAAAAGT
GAAGATTTGGGAACAGTTCAGGAGAAGTCCACCAAAAGCCTTGTTATAGGTCCTCTTGATTTTCGTTTGGATAGCAGTGCGGTGCATAGG
ATTTTGAAAATGATTGTGTGTGCCTTGGAACATGAATATGAACCATATAGCAGGCTAAAATCAGATATTAAGGATGAAAATGAAACAATA
CTGAATCCTGAAGAGGTGGCTCTTCTGGAGGAATATATTCCTACTCGACATACAAGTGTTACTCTCCTCAAATGTACCTGCACAATTTCC
ATGGCTGAATTCAACTTGCTGGACCATTTACTACCTGTCATTATGGGAGAAAAGAACTCAAGTAACTTCATGAATACTACAAACTTCCAG
TCTCTTCGGCCTTTGCCATCCATTCGAATATTGGTGGATAAAATTAATCTGGAACATTCAGTGCCAATGTATGCTGAACAGTTGGTGCAT
GTGGTCAGCAGCCTTACTCAACCTTCTGATAACCTGCTTCATTATTGTTATGTACACTGCTATCTTAAGATATTTGGTTTCCAGGCAGGA
CTGACGTCTTTGGATTGCAGTGGATCTTACTGCTTACCTGTACCAGTTATTCCCTCTTTCAGCACTGCTCTTTATGGGAAACTTCTGAAA
CTCCCCACATGCTGGACCAAAAGATCTCAGATTGCTATAACTGAAGGTATATTTGAACTTCCAAATCTCACAATTCAAGCTACAAGAGCA
CAGACACTTCTCTTGCAAGCAATATATCAAAGTTGGTCTCATCTTGGAAATGTCAGCTCTTCCGCAGTGATTGAAGCTTTGATAAATGAA
ATCTTCCTAAGTATAGTTCATTCGGCTCCTAAAGAAGTAGCAGTGTCCAAGGAACAAGAAGAGAAATCTGATAGCCTAGTTAAATATTTC
AGTGTTGTTTGGTGTAAGCCTTCAAAGAAAAAACATAAAAAGTGGGAAGGTGATGCTGTTCTTATTGTAAAAGGAAAGTCATTTATATTA
AAGAATTTGGAAGGCAAAGACATTGGAAGAGGCATTGGTTATAAATTCAAAGAGCTTGAAAAGATTGAAGAGGGCCAAACACTGATGATT
TGTGGAAAAGAAATAGAAGTCATGGGTGTAATCTCTCCAGATGACTTCAGCAGTGGCAGGTGTTTTCAGCTTGGAGGAGGAAGTACTGCT
ATCTCGCATTCTTCTCAGGTTGCCAGGAAATGTTTCTCTAACCCTTTCAAAAGTGTTTGTAAACCAAGTTCAAAGGAAAATAGACAGAAT
GATTTCCAAAATTGCAAACCACGCCATGACCCATATACGCCAAATTCCCTCGTTATGCCACGACCAGATAAGAATCACCAGTGGGTATTC
AATAAGAACTGTTTCCCTCTTGTGGATGTAGTGATTGATCCTTACCTTGTATATCATCTTCGACCACATCAGAAAGAAGGAATCATATTC
CTTTATGAATGTGTAATGGGAATGAGAATGAATGGCAGATGTGGAGCTATTCTTGCTGATGAAATGGGTTTAGGGAAGACATTGCAATGT
ATTTCGCTCATCTGGACCCTGCAGTGTCAGGGACCCTATGGAGGCAAGCCAGTAATAAAGAAGACACTAATTGTCACACCTGGAAGCTTG
GTGAATAATTGGAAGAAAGAATTTCAAAAATGGCTAGGAAGTGAAAGGATCAAGATATTTACTGTTGATCAGGACCACAAAGTTGAAGAA
TTCATCAAGTCTATATTTTATTCTGTTCTTATTATCAGTTATGAAATGTTACTTCGTTCCCTGGATCAAATTAAGAATATAAAATTTGAT
CTTCTAATCTGTGACGAGGGGCATCGTTTGAAGAACAGTGCCATTAAGACAACTACAGCCCTCATTAGCCTTTCTTGTGAGAAAAGAATA
ATTCTAACTGGTACTCCAATTCAGAATGATCTGCAAGAATTTTTTGCATTAATTGATTTTGTAAATCCAGGAATATTAGGCTCTTTGTCA
TCTTATAGGAAAATATATGAAGAACCCATCATTTTATCGAGAGAACCTTCTGCTTCTGAGGAAGAAAAGGAGTTAGGAGAAAGAAGAGCA
GCTGAACTTACTTGCCTCACTGGACTCTTTATCCTTAGAAGAACCCAAGAAATTATAAATAAATATCTCCCACCTAAAATAGAGAATGTT
GTCTTTTGCCGACCAGGAGCACTACAGATTGAGCTTTATCGAAAGCTGTTAAATTCTCAGGTTGTCAGGTTCTGCCTTCAAGGGTTGTTG
GAAAATAGTCCCCATCTAATATGTATAGGAGCTCTTAAAAAACTGTGCAATCACCCCTGCCTTTTGTTCAACTCTATAAAGGAAAAGGAA
TGTAGCTCAACTTGTGATAAAAATGAAGAAAAGAGTCTATACAAAGGCTTGCTAAGTGTGTTTCCTGCTGACTACAACCCTCTCCTGTTT
ACTGAAAAGGAGTCAGGAAAACTACAGGTGTTGTCCAAGCTCTTAGCGGTTATCCACGAACTTCGACCTACTGAAAAGGTGGTGTTGGTA
TCCAACTATACACAAACCTTGAACATTTTACAAGAAGTATGTAAGCGTCATGGATATGCTTATACAAGACTTGATGGACAAACACCAATC
TCTCAAAGGCAGCAGATTGTTGATGGCTTTAACAGTCAACACTCTTCTTTTTTTATTTTTTTGTTAAGTTCAAAAGCTGGTGGTGTAGGA
CTTAACCTCATTGGAGGATCTCACTTAATTCTCTATGACATTGATTGGAATCCAGCCACTGACATTCAGGCAATGTCTAGAGTATGGAGA
GATGGTCAGAAATATCCTGTACATATTTACAGACTCCTAACTACAGGTACAATAGAAGAAAAGATCTATCAAAGGCAGATCAGTAAGCAA
GGTCTTTGTGGGGCAGTTGTCGACCTCACCAAGACATCTGAACATATTCAGTTTTCAGTAGAAGAACTTAAAAATTTGTTCACATTACAT
GAAAGTTCAGATTGTGTTACTCATGATCTGCTTGACTGTGAGTGTACAGGAGAAGAAGTTCATACAGGTGATTCGTTGGAAAAATTCATT
GTCTCTAGAGATTGTCAGCTTGGTCCACATCACCAGAAATCTAACTCCCTGAAACCTCTTTCTATGTCCCAGCTGAAGCAATGGAAACAT
TTTTCTGGAGATCATTTAAATCTTACAGATCCTTTTCTTGAAAGAATAACAGAAAATGTGTCATTCATTTTTCAGAATATAACCACTCAA
GCTACTGGCACATAGTGAAAGATTACTTCTGACATTCCATTGCTCTTCTTTTGAAAATTAGTATGGTAATTAAATGTACTTTTTGAAAAT
TAATAGAATTATTTAAATTACAGTATATGTTGCAAAATATATCACTTTTGATACAATAGTCAAAATTGAGTGGTTTAATGTTTTGTAAAT

>98288_98288_3_VPS13B-RAD54B_VPS13B_chr8_100205285_ENST00000358544_RAD54B_chr8_95423543_ENST00000336148_length(amino acids)=1647AA_BP=834
MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELRIHVPWTKLGSEPVVITINTMECIL
KLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYT
VGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQ
LPMFIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQDEEQPQGWVSWAWSFVPAIVSYD
DGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRFGAFYMDY
LYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPEEVA
LLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQ
PSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLLLQA
IYQSWSHLGNVSSSAVIEALINEIFLSIVHSAPKEVAVSKEQEEKSDSLVKYFSVVWCKPSKKKHKKWEGDAVLIVKGKSFILKNLEGKD
IGRGIGYKFKELEKIEEGQTLMICGKEIEVMGVISPDDFSSGRCFQLGGGSTAISHSSQVARKCFSNPFKSVCKPSSKENRQNDFQNCKP
RHDPYTPNSLVMPRPDKNHQWVFNKNCFPLVDVVIDPYLVYHLRPHQKEGIIFLYECVMGMRMNGRCGAILADEMGLGKTLQCISLIWTL
QCQGPYGGKPVIKKTLIVTPGSLVNNWKKEFQKWLGSERIKIFTVDQDHKVEEFIKSIFYSVLIISYEMLLRSLDQIKNIKFDLLICDEG
HRLKNSAIKTTTALISLSCEKRIILTGTPIQNDLQEFFALIDFVNPGILGSLSSYRKIYEEPIILSREPSASEEEKELGERRAAELTCLT
GLFILRRTQEIINKYLPPKIENVVFCRPGALQIELYRKLLNSQVVRFCLQGLLENSPHLICIGALKKLCNHPCLLFNSIKEKECSSTCDK
NEEKSLYKGLLSVFPADYNPLLFTEKESGKLQVLSKLLAVIHELRPTEKVVLVSNYTQTLNILQEVCKRHGYAYTRLDGQTPISQRQQIV
DGFNSQHSSFFIFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKYPVHIYRLLTTGTIEEKIYQRQISKQGLCGAVV
DLTKTSEHIQFSVEELKNLFTLHESSDCVTHDLLDCECTGEEVHTGDSLEKFIVSRDCQLGPHHQKSNSLKPLSMSQLKQWKHFSGDHLN

--------------------------------------------------------------
>98288_98288_4_VPS13B-RAD54B_VPS13B_chr8_100205285_ENST00000395996_RAD54B_chr8_95423543_ENST00000336148_length(transcript)=5265nt_BP=2626nt
GGCGCGGTACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTCTTCCGAC
TTCGACTCCTTACCTTAAAAGATGCTGGAGTCATATGTAACTCCAATTTTAATGAGCTATGTGAATCGCTACATCAAGAACTTAAAGCCG
TCGGATCTACAGCTTTCACTATGGGGTGGAGACGTGGTACTCAGCAAGCTCGAGTTAAAGTTGGATGTGCTGGAACAGGAACTGAAATTA
CCATTCACTTTTTTAAGTGGACATATTCATGAATTGAGGATTCATGTACCATGGACAAAACTGGGTTCAGAACCAGTGGTAATTACCATC
AATACTATGGAATGCATTTTGAAACTTAAGGATGGGATACAGGATGACCATGAAAGCTGTGGTTCTAATTCTACCAACCGTAGTACTGCT
GAGAGCACAAAATCATCAATCAAACCGCGGAGAATGCAGCAGGCTGCTCCTACAGATCCTGACTTACCACCAGGTTATGTGCAGAGTCTG
ATTAGACGAGTTGTAAATAATGTAAACATTGTGATAAATAATCTCATACTAAAATATGTTGAAGATGATATCGTCCTTTCCGTCAATATC
ACTTCTGCAGAATGTTATACAGTAGGTGAATTATGGGATCGTGCATTCATGGATATTTCTGCAACTGATTTGGTGCTGAGAAAGGTTATC
AATTTTTCTGACTGTACAGTTTGTCTTGATAAACGGAATGCCAGTGGTAAAATAGAATTTTACCAGGATCCTTTATTATACAAATGTTCC
TTCAGAACTCGTCTTCATTTTACATATGAAAACCTAAATTCCAAGATGCCATCTGTTATTAAAATTCATACTTTAGTGGAAAGTTTGAAA
CTTTCTATCACAGATCAACAACTGCCTATGTTTATTCGTATAATGCAACTTGGAATTGCTCTTTACTATGGAGAAATAGGCAATTTTAAA
GAAGGCGAAATAGAGGACCTTACTTGTCATAATAAAGATATGCTAGGAAACATTACAGGTTCTGAAGATGAAACAAGAATAGATATGCAA
TATCCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAGCAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTG
CCTGCAATTGTGAGTTATGACGATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCACAGACTTTG
AAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACTTTCAAACTCACAGAAATGCAAGTTGAGAGTAGTTATTAC
AGTCCACAGAAAGTAAAATCTAAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAGGCCCTTATGATGGGAGAACCTTTCTTT
GATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAAAGGAATTATGGGTGTTAAAGATTTTGAAGAGAATATGAATAGAAGT
GAAACTGAAGCCTGTTTCTTCATTTGTGGTGACAATTTGAGTACGAAAGGTTTCACATACCTTACAAATTCATTGTTTGATTACCGAAGC
CCAGAAAATAATGGTACTCGCGCAGAATTTATCTTGGATTCAACTCATCATAAGGAGACATACACTGAGATAGCTGGAATGCAACGGTTT
GGGGCTTTTTATATGGATTACCTGTATACAATGGAGAACACTAGTGGCAAAGGTTCCACAAATCAACAAGACTTTTCTTCAGGGAAAAGT
GAAGATTTGGGAACAGTTCAGGAGAAGTCCACCAAAAGCCTTGTTATAGGTCCTCTTGATTTTCGTTTGGATAGCAGTGCGGTGCATAGG
ATTTTGAAAATGATTGTGTGTGCCTTGGAACATGAATATGAACCATATAGCAGGCTAAAATCAGATATTAAGGATGAAAATGAAACAATA
CTGAATCCTGAAGAGGTGGCTCTTCTGGAGGAATATATTCCTACTCGACATACAAGTGTTACTCTCCTCAAATGTACCTGCACAATTTCC
ATGGCTGAATTCAACTTGCTGGACCATTTACTACCTGTCATTATGGGAGAAAAGAACTCAAGTAACTTCATGAATACTACAAACTTCCAG
TCTCTTCGGCCTTTGCCATCCATTCGAATATTGGTGGATAAAATTAATCTGGAACATTCAGTGCCAATGTATGCTGAACAGTTGGTGCAT
GTGGTCAGCAGCCTTACTCAACCTTCTGATAACCTGCTTCATTATTGTTATGTACACTGCTATCTTAAGATATTTGGTTTCCAGGCAGGA
CTGACGTCTTTGGATTGCAGTGGATCTTACTGCTTACCTGTACCAGTTATTCCCTCTTTCAGCACTGCTCTTTATGGGAAACTTCTGAAA
CTCCCCACATGCTGGACCAAAAGATCTCAGATTGCTATAACTGAAGGTATATTTGAACTTCCAAATCTCACAATTCAAGCTACAAGAGCA
CAGACACTTCTCTTGCAAGCAATATATCAAAGTTGGTCTCATCTTGGAAATGTCAGCTCTTCCGCAGTGATTGAAGCTTTGATAAATGAA
ATCTTCCTAAGTATAGTTCATTCGGCTCCTAAAGAAGTAGCAGTGTCCAAGGAACAAGAAGAGAAATCTGATAGCCTAGTTAAATATTTC
AGTGTTGTTTGGTGTAAGCCTTCAAAGAAAAAACATAAAAAGTGGGAAGGTGATGCTGTTCTTATTGTAAAAGGAAAGTCATTTATATTA
AAGAATTTGGAAGGCAAAGACATTGGAAGAGGCATTGGTTATAAATTCAAAGAGCTTGAAAAGATTGAAGAGGGCCAAACACTGATGATT
TGTGGAAAAGAAATAGAAGTCATGGGTGTAATCTCTCCAGATGACTTCAGCAGTGGCAGGTGTTTTCAGCTTGGAGGAGGAAGTACTGCT
ATCTCGCATTCTTCTCAGGTTGCCAGGAAATGTTTCTCTAACCCTTTCAAAAGTGTTTGTAAACCAAGTTCAAAGGAAAATAGACAGAAT
GATTTCCAAAATTGCAAACCACGCCATGACCCATATACGCCAAATTCCCTCGTTATGCCACGACCAGATAAGAATCACCAGTGGGTATTC
AATAAGAACTGTTTCCCTCTTGTGGATGTAGTGATTGATCCTTACCTTGTATATCATCTTCGACCACATCAGAAAGAAGGAATCATATTC
CTTTATGAATGTGTAATGGGAATGAGAATGAATGGCAGATGTGGAGCTATTCTTGCTGATGAAATGGGTTTAGGGAAGACATTGCAATGT
ATTTCGCTCATCTGGACCCTGCAGTGTCAGGGACCCTATGGAGGCAAGCCAGTAATAAAGAAGACACTAATTGTCACACCTGGAAGCTTG
GTGAATAATTGGAAGAAAGAATTTCAAAAATGGCTAGGAAGTGAAAGGATCAAGATATTTACTGTTGATCAGGACCACAAAGTTGAAGAA
TTCATCAAGTCTATATTTTATTCTGTTCTTATTATCAGTTATGAAATGTTACTTCGTTCCCTGGATCAAATTAAGAATATAAAATTTGAT
CTTCTAATCTGTGACGAGGGGCATCGTTTGAAGAACAGTGCCATTAAGACAACTACAGCCCTCATTAGCCTTTCTTGTGAGAAAAGAATA
ATTCTAACTGGTACTCCAATTCAGAATGATCTGCAAGAATTTTTTGCATTAATTGATTTTGTAAATCCAGGAATATTAGGCTCTTTGTCA
TCTTATAGGAAAATATATGAAGAACCCATCATTTTATCGAGAGAACCTTCTGCTTCTGAGGAAGAAAAGGAGTTAGGAGAAAGAAGAGCA
GCTGAACTTACTTGCCTCACTGGACTCTTTATCCTTAGAAGAACCCAAGAAATTATAAATAAATATCTCCCACCTAAAATAGAGAATGTT
GTCTTTTGCCGACCAGGAGCACTACAGATTGAGCTTTATCGAAAGCTGTTAAATTCTCAGGTTGTCAGGTTCTGCCTTCAAGGGTTGTTG
GAAAATAGTCCCCATCTAATATGTATAGGAGCTCTTAAAAAACTGTGCAATCACCCCTGCCTTTTGTTCAACTCTATAAAGGAAAAGGAA
TGTAGCTCAACTTGTGATAAAAATGAAGAAAAGAGTCTATACAAAGGCTTGCTAAGTGTGTTTCCTGCTGACTACAACCCTCTCCTGTTT
ACTGAAAAGGAGTCAGGAAAACTACAGGTGTTGTCCAAGCTCTTAGCGGTTATCCACGAACTTCGACCTACTGAAAAGGTGGTGTTGGTA
TCCAACTATACACAAACCTTGAACATTTTACAAGAAGTATGTAAGCGTCATGGATATGCTTATACAAGACTTGATGGACAAACACCAATC
TCTCAAAGGCAGCAGATTGTTGATGGCTTTAACAGTCAACACTCTTCTTTTTTTATTTTTTTGTTAAGTTCAAAAGCTGGTGGTGTAGGA
CTTAACCTCATTGGAGGATCTCACTTAATTCTCTATGACATTGATTGGAATCCAGCCACTGACATTCAGGCAATGTCTAGAGTATGGAGA
GATGGTCAGAAATATCCTGTACATATTTACAGACTCCTAACTACAGGTACAATAGAAGAAAAGATCTATCAAAGGCAGATCAGTAAGCAA
GGTCTTTGTGGGGCAGTTGTCGACCTCACCAAGACATCTGAACATATTCAGTTTTCAGTAGAAGAACTTAAAAATTTGTTCACATTACAT
GAAAGTTCAGATTGTGTTACTCATGATCTGCTTGACTGTGAGTGTACAGGAGAAGAAGTTCATACAGGTGATTCGTTGGAAAAATTCATT
GTCTCTAGAGATTGTCAGCTTGGTCCACATCACCAGAAATCTAACTCCCTGAAACCTCTTTCTATGTCCCAGCTGAAGCAATGGAAACAT
TTTTCTGGAGATCATTTAAATCTTACAGATCCTTTTCTTGAAAGAATAACAGAAAATGTGTCATTCATTTTTCAGAATATAACCACTCAA
GCTACTGGCACATAGTGAAAGATTACTTCTGACATTCCATTGCTCTTCTTTTGAAAATTAGTATGGTAATTAAATGTACTTTTTGAAAAT
TAATAGAATTATTTAAATTACAGTATATGTTGCAAAATATATCACTTTTGATACAATAGTCAAAATTGAGTGGTTTAATGTTTTGTAAAT

>98288_98288_4_VPS13B-RAD54B_VPS13B_chr8_100205285_ENST00000395996_RAD54B_chr8_95423543_ENST00000336148_length(amino acids)=1647AA_BP=834
MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELRIHVPWTKLGSEPVVITINTMECIL
KLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYT
VGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQ
LPMFIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQDEEQPQGWVSWAWSFVPAIVSYD
DGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRFGAFYMDY
LYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPEEVA
LLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQ
PSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLLLQA
IYQSWSHLGNVSSSAVIEALINEIFLSIVHSAPKEVAVSKEQEEKSDSLVKYFSVVWCKPSKKKHKKWEGDAVLIVKGKSFILKNLEGKD
IGRGIGYKFKELEKIEEGQTLMICGKEIEVMGVISPDDFSSGRCFQLGGGSTAISHSSQVARKCFSNPFKSVCKPSSKENRQNDFQNCKP
RHDPYTPNSLVMPRPDKNHQWVFNKNCFPLVDVVIDPYLVYHLRPHQKEGIIFLYECVMGMRMNGRCGAILADEMGLGKTLQCISLIWTL
QCQGPYGGKPVIKKTLIVTPGSLVNNWKKEFQKWLGSERIKIFTVDQDHKVEEFIKSIFYSVLIISYEMLLRSLDQIKNIKFDLLICDEG
HRLKNSAIKTTTALISLSCEKRIILTGTPIQNDLQEFFALIDFVNPGILGSLSSYRKIYEEPIILSREPSASEEEKELGERRAAELTCLT
GLFILRRTQEIINKYLPPKIENVVFCRPGALQIELYRKLLNSQVVRFCLQGLLENSPHLICIGALKKLCNHPCLLFNSIKEKECSSTCDK
NEEKSLYKGLLSVFPADYNPLLFTEKESGKLQVLSKLLAVIHELRPTEKVVLVSNYTQTLNILQEVCKRHGYAYTRLDGQTPISQRQQIV
DGFNSQHSSFFIFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKYPVHIYRLLTTGTIEEKIYQRQISKQGLCGAVV
DLTKTSEHIQFSVEELKNLFTLHESSDCVTHDLLDCECTGEEVHTGDSLEKFIVSRDCQLGPHHQKSNSLKPLSMSQLKQWKHFSGDHLN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for VPS13B-RAD54B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for VPS13B-RAD54B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for VPS13B-RAD54B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source