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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VPS13B-RGS22 (FusionGDB2 ID:98290)

Fusion Gene Summary for VPS13B-RGS22

check button Fusion gene summary
Fusion gene informationFusion gene name: VPS13B-RGS22
Fusion gene ID: 98290
HgeneTgene
Gene symbol

VPS13B

RGS22

Gene ID

157680

26166

Gene namevacuolar protein sorting 13 homolog Bregulator of G protein signaling 22
SynonymsCHS1|COH1CT145|PRTD-NY2
Cytomap

8q22.2

8q22.2

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 13Bregulator of G-protein signaling 22
Modification date2020031320200320
UniProtAcc.

Q8NE09

Ensembl transtripts involved in fusion geneENST00000395996, ENST00000521932, 
ENST00000357162, ENST00000358544, 
ENST00000355155, ENST00000441350, 
ENST00000360863, ENST00000523287, 
ENST00000523437, ENST00000519421, 
Fusion gene scores* DoF score43 X 36 X 17=263166 X 7 X 4=168
# samples 507
** MAII scorelog2(50/26316*10)=-5.71786831273266
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VPS13B [Title/Abstract] AND RGS22 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVPS13B(100205285)-RGS22(100994344), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across VPS13B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RGS22 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AY-A71X-01AVPS13Bchr8

100821758

-RGS22chr8

101092583

-
ChimerDB4STADTCGA-VQ-A8DZ-01AVPS13Bchr8

100205285

-RGS22chr8

100994344

-
ChimerDB4STADTCGA-VQ-A8DZVPS13Bchr8

100205285

+RGS22chr8

100994344

-


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Fusion Gene ORF analysis for VPS13B-RGS22

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000395996ENST00000360863VPS13Bchr8

100821758

-RGS22chr8

101092583

-
3UTR-3CDSENST00000521932ENST00000360863VPS13Bchr8

100205285

+RGS22chr8

100994344

-
3UTR-3CDSENST00000521932ENST00000523287VPS13Bchr8

100205285

+RGS22chr8

100994344

-
3UTR-3CDSENST00000521932ENST00000523437VPS13Bchr8

100205285

+RGS22chr8

100994344

-
3UTR-5UTRENST00000395996ENST00000523287VPS13Bchr8

100821758

-RGS22chr8

101092583

-
3UTR-5UTRENST00000395996ENST00000523437VPS13Bchr8

100821758

-RGS22chr8

101092583

-
3UTR-intronENST00000395996ENST00000519421VPS13Bchr8

100821758

-RGS22chr8

101092583

-
3UTR-intronENST00000521932ENST00000519421VPS13Bchr8

100205285

+RGS22chr8

100994344

-
5CDS-5UTRENST00000357162ENST00000523287VPS13Bchr8

100821758

-RGS22chr8

101092583

-
5CDS-5UTRENST00000357162ENST00000523437VPS13Bchr8

100821758

-RGS22chr8

101092583

-
5CDS-5UTRENST00000358544ENST00000523287VPS13Bchr8

100821758

-RGS22chr8

101092583

-
5CDS-5UTRENST00000358544ENST00000523437VPS13Bchr8

100821758

-RGS22chr8

101092583

-
5CDS-intronENST00000355155ENST00000519421VPS13Bchr8

100205285

+RGS22chr8

100994344

-
5CDS-intronENST00000357162ENST00000519421VPS13Bchr8

100821758

-RGS22chr8

101092583

-
5CDS-intronENST00000357162ENST00000519421VPS13Bchr8

100205285

+RGS22chr8

100994344

-
5CDS-intronENST00000358544ENST00000519421VPS13Bchr8

100821758

-RGS22chr8

101092583

-
5CDS-intronENST00000358544ENST00000519421VPS13Bchr8

100205285

+RGS22chr8

100994344

-
5CDS-intronENST00000395996ENST00000519421VPS13Bchr8

100205285

+RGS22chr8

100994344

-
Frame-shiftENST00000355155ENST00000360863VPS13Bchr8

100205285

+RGS22chr8

100994344

-
Frame-shiftENST00000355155ENST00000523287VPS13Bchr8

100205285

+RGS22chr8

100994344

-
Frame-shiftENST00000355155ENST00000523437VPS13Bchr8

100205285

+RGS22chr8

100994344

-
Frame-shiftENST00000357162ENST00000360863VPS13Bchr8

100205285

+RGS22chr8

100994344

-
Frame-shiftENST00000357162ENST00000523287VPS13Bchr8

100205285

+RGS22chr8

100994344

-
Frame-shiftENST00000357162ENST00000523437VPS13Bchr8

100205285

+RGS22chr8

100994344

-
Frame-shiftENST00000358544ENST00000360863VPS13Bchr8

100205285

+RGS22chr8

100994344

-
Frame-shiftENST00000358544ENST00000523287VPS13Bchr8

100205285

+RGS22chr8

100994344

-
Frame-shiftENST00000358544ENST00000523437VPS13Bchr8

100205285

+RGS22chr8

100994344

-
Frame-shiftENST00000395996ENST00000360863VPS13Bchr8

100205285

+RGS22chr8

100994344

-
Frame-shiftENST00000395996ENST00000523287VPS13Bchr8

100205285

+RGS22chr8

100994344

-
Frame-shiftENST00000395996ENST00000523437VPS13Bchr8

100205285

+RGS22chr8

100994344

-
In-frameENST00000357162ENST00000360863VPS13Bchr8

100821758

-RGS22chr8

101092583

-
In-frameENST00000358544ENST00000360863VPS13Bchr8

100821758

-RGS22chr8

101092583

-
intron-3CDSENST00000355155ENST00000360863VPS13Bchr8

100821758

-RGS22chr8

101092583

-
intron-3CDSENST00000441350ENST00000360863VPS13Bchr8

100821758

-RGS22chr8

101092583

-
intron-3CDSENST00000441350ENST00000360863VPS13Bchr8

100205285

+RGS22chr8

100994344

-
intron-3CDSENST00000441350ENST00000523287VPS13Bchr8

100205285

+RGS22chr8

100994344

-
intron-3CDSENST00000441350ENST00000523437VPS13Bchr8

100205285

+RGS22chr8

100994344

-
intron-3CDSENST00000521932ENST00000360863VPS13Bchr8

100821758

-RGS22chr8

101092583

-
intron-5UTRENST00000355155ENST00000523287VPS13Bchr8

100821758

-RGS22chr8

101092583

-
intron-5UTRENST00000355155ENST00000523437VPS13Bchr8

100821758

-RGS22chr8

101092583

-
intron-5UTRENST00000441350ENST00000523287VPS13Bchr8

100821758

-RGS22chr8

101092583

-
intron-5UTRENST00000441350ENST00000523437VPS13Bchr8

100821758

-RGS22chr8

101092583

-
intron-5UTRENST00000521932ENST00000523287VPS13Bchr8

100821758

-RGS22chr8

101092583

-
intron-5UTRENST00000521932ENST00000523437VPS13Bchr8

100821758

-RGS22chr8

101092583

-
intron-intronENST00000355155ENST00000519421VPS13Bchr8

100821758

-RGS22chr8

101092583

-
intron-intronENST00000441350ENST00000519421VPS13Bchr8

100821758

-RGS22chr8

101092583

-
intron-intronENST00000441350ENST00000519421VPS13Bchr8

100205285

+RGS22chr8

100994344

-
intron-intronENST00000521932ENST00000519421VPS13Bchr8

100821758

-RGS22chr8

101092583

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358544VPS13Bchr8100821758-ENST00000360863RGS22chr8101092583-122678283111119603949
ENST00000357162VPS13Bchr8100821758-ENST00000360863RGS22chr8101092583-121928208111118853924

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358544ENST00000360863VPS13Bchr8100821758-RGS22chr8101092583-0.0002869650.999713
ENST00000357162ENST00000360863VPS13Bchr8100821758-RGS22chr8101092583-0.0002999260.99970007

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Fusion Genomic Features for VPS13B-RGS22


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VPS13B-RGS22


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:100205285/chr8:100994344)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RGS22

Q8NE09

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRGS22chr8:100821758chr8:101092583ENST000003608632281142_1174391285.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneRGS22chr8:100821758chr8:101092583ENST00000360863228267_277391285.6666666666667Compositional biasNote=Poly-Glu
TgeneRGS22chr8:100821758chr8:101092583ENST00000360863228767_771391285.6666666666667Compositional biasNote=Poly-Leu
TgeneRGS22chr8:100821758chr8:101092583ENST000003608632281021_1145391285.6666666666667DomainRGS 2
TgeneRGS22chr8:100821758chr8:101092583ENST00000360863228852_980391285.6666666666667DomainRGS 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for VPS13B-RGS22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98290_98290_1_VPS13B-RGS22_VPS13B_chr8_100821758_ENST00000357162_RGS22_chr8_101092583_ENST00000360863_length(transcript)=12192nt_BP=8208nt
GGCGCGGTACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTCTTCCGAC
TTCGACTCCTTACCTTAAAAGATGCTGGAGTCATATGTAACTCCAATTTTAATGAGCTATGTGAATCGCTACATCAAGAACTTAAAGCCG
TCGGATCTACAGCTTTCACTATGGGGTGGAGACGTGGTACTCAGCAAGCTCGAGTTAAAGTTGGATGTGCTGGAACAGGAACTGAAATTA
CCATTCACTTTTTTAAGTGGACATATTCATGAATTGAGGATTCATGTACCATGGACAAAACTGGGTTCAGAACCAGTGGTAATTACCATC
AATACTATGGAATGCATTTTGAAACTTAAGGATGGGATACAGGATGACCATGAAAGCTGTGGTTCTAATTCTACCAACCGTAGTACTGCT
GAGAGCACAAAATCATCAATCAAACCGCGGAGAATGCAGCAGGCTGCTCCTACAGATCCTGACTTACCACCAGGTTATGTGCAGAGTCTG
ATTAGACGAGTTGTAAATAATGTAAACATTGTGATAAATAATCTCATACTAAAATATGTTGAAGATGATATCGTCCTTTCCGTCAATATC
ACTTCTGCAGAATGTTATACAGTAGGTGAATTATGGGATCGTGCATTCATGGATATTTCTGCAACTGATTTGGTGCTGAGAAAGGTTATC
AATTTTTCTGACTGTACAGTTTGTCTTGATAAACGGAATGCCAGTGGTAAAATAGAATTTTACCAGGATCCTTTATTATACAAATGTTCC
TTCAGAACTCGTCTTCATTTTACATATGAAAACCTAAATTCCAAGATGCCATCTGTTATTAAAATTCATACTTTAGTGGAAAGTTTGAAA
CTTTCTATCACAGATCAACAACTGCCTATGTTTATTCGTATAATGCAACTTGGAATTGCTCTTTACTATGGAGAAATAGGCAATTTTAAA
GAAGGCGAAATAGAGGACCTTACTTGTCATAATAAAGATATGCTAGGAAACATTACAGGTTCTGAAGATGAAACAAGAATAGATATGCAA
TATCCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAGCAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTG
CCTGCAATTGTGAGTTATGACGATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCACAGACTTTG
AAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACTTTCAAACTCACAGAAATGCAAGTTGAGAGTAGTTATTAC
AGTCCACAGAAAGTAAAATCTAAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAGGCCCTTATGATGGGAGAACCTTTCTTT
GATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAAAGGAATTATGGGTGTTAAAGATTTTGAAGAGAATATGAATAGAAGT
GAAACTGAAGCCTGTTTCTTCATTTGTGGTGACAATTTGAGTACGAAAGGTTTCACATACCTTACAAATTCATTGTTTGATTACCGAAGC
CCAGAAAATAATGGTACTCGCGCAGAATTTATCTTGGATTCAACTCATCATAAGGAGACATACACTGAGATAGCTGGAATGCAACGGTTT
GGGGCTTTTTATATGGATTACCTGTATACAATGGAGAACACTAGTGGCAAAGGTTCCACAAATCAACAAGACTTTTCTTCAGGGAAAAGT
GAAGATTTGGGAACAGTTCAGGAGAAGTCCACCAAAAGCCTTGTTATAGGTCCTCTTGATTTTCGTTTGGATAGCAGTGCGGTGCATAGG
ATTTTGAAAATGATTGTGTGTGCCTTGGAACATGAATATGAACCATATAGCAGGCTAAAATCAGATATTAAGGATGAAAATGAAACAATA
CTGAATCCTGAAGAGGTGGCTCTTCTGGAGGAATATATTCCTACTCGACATACAAGTGTTACTCTCCTCAAATGTACCTGCACAATTTCC
ATGGCTGAATTCAACTTGCTGGACCATTTACTACCTGTCATTATGGGAGAAAAGAACTCAAGTAACTTCATGAATACTACAAACTTCCAG
TCTCTTCGGCCTTTGCCATCCATTCGAATATTGGTGGATAAAATTAATCTGGAACATTCAGTGCCAATGTATGCTGAACAGTTGGTGCAT
GTGGTCAGCAGCCTTACTCAACCTTCTGATAACCTGCTTCATTATTGTTATGTACACTGCTATCTTAAGATATTTGGTTTCCAGGCAGGA
CTGACGTCTTTGGATTGCAGTGGATCTTACTGCTTACCTGTACCAGTTATTCCCTCTTTCAGCACTGCTCTTTATGGGAAACTTCTGAAA
CTCCCCACATGCTGGACCAAAAGATCTCAGATTGCTATAACTGAAGGTATATTTGAACTTCCAAATCTCACAATTCAAGCTACAAGAGCA
CAGACACTTCTCTTGCAAGCAATATATCAAAGTTGGTCTCATCTTGGAAATGTCAGCTCTTCCGCAGTGATTGAAGCTTTGATAAATGAA
ATCTTCCTAAGTATAGGTGTGAAATCTAAGAATCCCCTGCCAACTCTTGAGGGCTCAATCCAGAATGTTGAATTGAAGTACTGCAGCACA
TCATTGGTCAAATGTGCCTCTGGGACCATGGGATCAATAAAAATTTGTGCCAAAGCCCCAGTTGATAGTGGAAAAGAGAAGTTGATTCCC
TTGCTTCAGGGTCCTTCTGACACTAAAGACCTTCATAGCACCAAGTGGCTCAATGAGAGTAGAAAGCCAGAGTCTCTCTTAGCTCCAGAT
TTGATGGCCTTCACAATCCAAGTTCCACAATATATTGACTACTGCCACAATTCCGGTGCTGTACTTCTTTGCAGTATACAAGGACTAGCA
GTTAATATTGACCCAATCTTATATACGTGGCTCATCTATCAGCCTCAGAAACGAACAAGTAGACATATGCAACAGCAGCCTGTGGTAGCT
GTTCCTCTTGTTATGCCAGTTTGTAGAAGGAAAGAGGATGAGGTGTCTATTGGAAGTGCCCCCTTGGCAAAGCAGCAATCATATCAGGCC
TCTGAATATGCCAGCAGCCCTGTAAAAACAAAAACGGTAACAGAATCCCGCCCATTGTCAGTTCCTGTTAAAGCCATGTTGAATATATCT
GAAAGCTGTAGAAGTCCTGAAGAAAGAATGAAGGAATTTATTGGAATTGTTTGGAATGCAGTGAAGCATCTCACACTACAGCTTGAAGTA
CAATCTTGTTGTGTGTTTATTCCAAATGATAGCCTGCCTTCCCCAAGTACAATTGTATCTGGTGACATTCCTGGAACAGTAAGAAGTTGG
TACCATGGACAAACCAGCATGCCGGGAACACTTGTCCTCTGTTTGCCTCAAATAAAGATTATTAGTGCTGGGCACAAGTATATGGAACCT
CTGCAGGAGATTCCATTTGTTATCCCACGACCCATCCTTGAAGAAGGTGATGCTTTTCCTTGGACGATCAGCTTGCATAATTTCAGCATA
TATACCCTTCTTGGAAAACAAGTGACACTTTGCCTAGTGGAACCTATGGGTTGCACCTCCACTCTAGCTGTCACGTCTCAAAAACTGCTT
GCTACGGGACCTGATACACGACATTCATTTGTTGTCTGTCTCCATGTTGACCTAGAGTCACTAGAGATAAAATGCTCTAATCCCCAGGTC
CAGCTCTTCTATGAACTAACTGATATCATGAATAAGGTCTGGAACAAGATTCAGAAGAGAGGCAATCTCAACCTATCTCCAACCTCTCCA
GAGACCATGGCAGGGCCTGTTCCTACTTCTCCAGTTAGAAGCAGTATAGGCACAGCTCCTCCAGATACCAGCACATGCAGCCCATCTGCT
GACATTGGGACTACTACTGAGGGAGATTCTATACAAGCAGGTGAGGAATCACCATTCTCAGATTCTGTGACCTTGGAACAAACTACAAGT
AATATTGGAGGAACCAGTGGACGTGTTAGTTTATGGATGCAGTGGGTGCTTCCCAAAATTACTATAAAGCTCTTTGCTCCAGATCCTGAA
AATAAAGGCACAGAGGTTTGTATGGTCAGTGAACTAGAAGATCTCAGTGCTTCCATAGATGTCCAGGATGTATATACCAAAGTGAAATGT
AAAATAGAGAGTTTCAATATTGATCACTATAGAAGCAGGCCAGGGGAAGGTTGGCAGTCAGGACATTTTGAAGGAGTATTTCTACAATGC
AAAGAAAAATCTGTGACAACTACAAAACTTCTAGATGGCACTCATCAGCAGCATGGATTCCTCTCTCTGACATACACAAAAGCTGTAACA
AAAAATGTCCGCCACAAGTTAACATCAAGAAATGAGCGAAGAAGTTTTCATAAGTTATCTGAAGGCCTAATGGATGGTTCTCCTCATTTT
CTTCATGAAATTCTTCTTTCAGCACAAGCTTTTGATATTGTTCTTTATTTTCCTTTACTTAATGCCATTGCAAGTATATTTCAAGCAAAA
CTACCAAAGACCCAAAAAGAGAAAAGAAAATCTCCTGGTCAGCCCATGAGGACCCATACACTGACATCCCGCAATTTACCTTTGATTTAT
GTCAACACAAGTGTAATCAGAATTTTTATTCCAAAAACAGAAGAAATGCAGCCAACTGTTGAAGCTAATCAGGCAGCAAAAGAAGACACT
GTGGTTTTGAAGATTGGCTCTGTTGCCATGGCTCCCCAGGCTGACAATCCCCTTGGCAGATCTGTCCTTAGGAAAGATATTTACCAGAGA
GCCTTGAACTTAGGAATTCTTCGAGATCCTGGATCAGAAATCGAAGACAGACAATACCAAATAGATCTGCAGTCCATCAATATTGGTACT
GCACAGTGGCATCAACTAAAACCAGAGAAGGAAAGTGTCTCAGGAGGGGTGGTAACAGAGACTGAAAGGAATTCTCAAAATCCAGCCCTT
GAGTGGAATATGGCCAGCAGCATACGGCGGCATCAAGAAAGGAGAGCAATTTTGACCCCCGTTTTGACAGATTTTTCTGTCCGAATAACT
GGAGCACCTGCTGTCATTTTCACCAAAGTAGTTTCTCCAGAAAATTTGCATACTGAGGAGATTTTAGTGTGTGGCCATTCCTTAGAAGTG
AATATAACCACAAACCTGGACTTCTTCCTAAGTGTGGCTCAAGTTCAACTCTTACATCAGTTAATAGTAGCAAATATGACTGGACTGGAA
CCATCAAACAAGGCTGCAGAGATCTCTAAACAAGAACAGAAAAAAGTGGATATATTTGATGGAGGCATGGCTGAAACCTCATCTCGCTAC
AGTGGTGCTCAGGATAGTGGAATTGGCAGTGACAGTGTTAAAATCAGAATAGTGCAAATAGAGCAGCACAGTGGTGCCAGTCAGCATCGC
ATTGCCCGTCCCTCACGCCAGTCATCAATTGTAAAAAATCTAAATTTTATTCCCTTTGACATATTTATTACTGCAAGTAGAATCTCACTA
ATGACCTATTCCTGTATGGCCTTATCCAAATCGAAATCACAAGAACAGAAGAATAATGAAAAAACAGACAAGAGTTCATTAAATCTCCCA
GAAGTTGATTCAGATGTTGCTAAGCCCAACCAGGCATGTATTTCCACGGTGACAGCAGAAGATCTCTTAAGGAGCAGCATTTCTTTTCCT
TCAGGGAAAAAAATAGGGGTCCTCTCTCTTGAAAGTCTTCATGCATCCACAAGGTCATCTGCTAGACAAGCACTTGGTATAACTATTGTT
CGGCAGCCTGGTCGAAGAGGAACTGGTGACTTACAGCTAGAGCCTTTTCTGTACTTTATTGTGTCCCAGCCTTCCTTGCTTCTGAGTTGT
CACCACAGAAAGCAGCGAGTGGAAGTATCCATTTTTGATGCTGTGCTTAAAGGGGTGGCCTCTGATTACAAATGTATAGATCCTGGGAAG
ACTCTGCCTGAAGCCCTTGATTATTGCACTGTTTGGCTACAGACAGTGCCTGGAGAAATAGACAGCAAAAGTGGTATTCCACCTTCCTTT
ATAACACTACAGATTAAAGACTTTCTGAATGGACCAGCGGATGTCAATTTGGATATATCAAAGCCTTTGAAAGCAAACCTGAGTTTCACC
AAACTGGATCAGATAAACCTTTTTTTAAAGAAGATAAAAAATGCACACAGTTTGGCACATAGTGAAGAGACTTCAGCCATGTCCAACACC
ATGGTGAATAAGGATGATCTTCCAGTCTCCAAATATTACCGTGGAAAGTTGTCTAAACCCAAAATTCATGGTGATGGAGTGCAAAAGATT
TCAGCTCAAGAAAACATGTGGAGAGCTGTTTCCTGCTTTCAAAAAATTTCTGTTCAAACTACTCAGATTGTGATCTCCATGGAAACTGTA
CCCCATACCAGCAAACCATGCCTGTTAGCATCTCTCTCAAACCTCAATGGAAGCCTTAGTGTCAAGGCAACACAAAAAGTACCTGGCATA
ATTCTTGGGTCATCATTTCTACTCAGTATAAACGATTTTCTCCTTAAAACAAGTCTCAAAGAAAGAAGCCGCATTCTGATAGGACCATGT
TGTGCTACTGCCAATCTGGAAGCTAAGTGGTGTAAACACAGCGGGAATCCAGGCCCAGAACAATCCATACCAAAAATATCCATTGACTTA
AGAGGAGGTCTACTACAGGTCTTCTGGGGTCAAGAACATTTGAATTGTTTAGTTCTTCTACATGAATTACTCAATGGATACCTTAATGAG
GAGGGAAATTTTGAAGTACAAGTTTCTGAACCAGTGCCTCAAATGTCATCTCCTGTGGAAAAGAATCAGACATTTAAAAGTGAACAAAGT
TCAGATGACCTACGGACAGGTCTATTTCAGTATGTACAGGATGCTGAATCTTTGAAATTGCCTGGGGTCTATGAAGTCTTATTTTATAAT
GAAACTGAAGATTGCCCAGGGATGATGTTATGGAGATATCCAGAACCTAGAGTACTCACCCTTGTACGAATAACTCCTGTACCTTTTAAC
ACCACAGAGGATCCAGATATTAGCACAGCAGACCTTGGTGATGTGCTACAGGTTCCTTGTAGCTTGGAATACTGGGATGAACTCCAGAAG
GTTTTTGTTGCATTTAGAGAATTTAATCTGTCTGAAAGCAAAGTTTGTGAACTGCAGTTGCCGGATATCAATCTCGTGAATGACCAGAAG
AAATTAGTATCTTCAGATCTTTGGAGAATTGTCTTGAACAGCAGTCAAAATGGAGCTGATGACCAAAGCTCTGCAAGTGAGTCTGGTTCT
CAAAGCACTTGTGATCCACTTGTGACTCCAACAGCCCTGGCTGCCTGTACCAGAGTTGACTCCTGCTTTACCCCATGGTTTGTCCCATCC
CTTTGCGTTTCTTTCCAGTTTGCTCACCTGGAATTCCATCTTTGTCATCACCTTGACCAACTAGGCACAGCTGCACCACAGTACCTACAG
CCATTTGTTTCCGACAGAAATATGCCATCTGAACTAGAATACATGATTGTTTCCTTCAGAGAACCACACATGTATCTTCGACAGTGGAAT
AATGGTTCTGTCTGTCAGGAGATCCAGTTCTTAGCTCAAGCAGACTGTAAACTTCTAGAGTGCAGAAATGTCACTATGCAAAGTGTGGTG
AAACCCTTCAGCATCTTCGGGCAGATGGCAGTTTCCAGCGATGTAGTGGAAAAGCTGCTTGACTGCACCGTGATAGTTGATTCTGTATTT
GTAAACCTTGGACAGCATGTAGTCCATTCACTAAACACTGCAATACAAGCTTGGCAACAGAACAAATGCCCTGAGGTAGAGGAGTTGGTC
TTCAGCCATTTTGTGATCTGTAATGACACACAGGAGACACTGCGGTTTGGCCAGGTGGATACTGATGAAAATATTCTGCTGGCGAGTCTC
CACAGTCACCAGTACAGCTGGCGCTCTCACAAATCCCCACAGCTGTTACACATCTGTATTGAAGGTTGGGGCAACTGGCGTTGGTCAGAG
CCTTTCAGTGTGGACCATGCCGGGACTTTTATTAGAACAATTCAGTACAGGGGTCGAACTGCTTCTCTCATCATCAAGGTTCAGCAACTC
AATGGAGTACAAAAACAGACCTTTTCAGAGGCAATTAGATTTAATGCAGATTATGGAGTTTTTGAAGTAGCTAATGATGCTCCACAATTT
CTGGAAAAACAACTGAAAAAAATTCTACAAAACCAGCAACCTCGAAATCCCATTTATGATGTTGTAAGGAAAGGAAAGAATGAGGTTAAA
CCTGTTCAAATGAATGCCCCCGATGAAGATGAGACCATTAATGTCAACTACAATATTATGTGTCTCAGTCGTGAAGAAGGTATTAAGTGG
ATCAAAAAAGAAAGACTTCCAGCATTTCTGGAAAGTGATTGTTACTTTGAATACAGGTTAGCCAAATTGGTCTCACAAGTAAGATGGAGC
AAGTCCGGCATGAATTTCACAGTAGGATCAAATTTTTCTCCCTGGATCGTGAAAAAACCACCCAGTCTACCACCTCCTGCCACTGAAGAA
GATAATCTTGTAATTATGAAAAAGTTCTATGTATCACTTGGTGAGGCTTCCTATACTCAAACAAAAGATTGGTTTGCATTAGCAAAACAA
AGTCAGCAAACAGTATCAACCTTTTCGTTACCCTGTTGTGTACCCTACAACAAACTTAAATCACCAGCTATTTCATCTGTTTCTGAGAAT
TTTATCTTTGATGATGGAGTTCACCCTAGGACAAAAAAGGACCCATCTAAAACCAACAAATTGATTTCTGAATTTGAAGAAGAAGAAGGA
GAAGAAGAAGAGGTGTCTGTATCTCTACAAGACACTCCTTCTCAAGCTCTTCTGAGAGTATACCTTGAAAAGAAACAGGATGTTGATGAA
AGCCTGACAATGCATTTCTCAACATGTGAAGAATTTTTAAGCTCCTATATATACTTTATTTTGAGAGGAGCAATTCAGCAAATTGTTGGA
AAGCCAGTTGGAGAAACCCCAGACTATATAAACTTCAACAATATAACAAAAGTGTCATTTGATGATTGTTTTGAGTCTATTCATGGCAAG
AATTTTTTAAGTGAATTAGTTCAAACTACAAAGGAGAGGTCAGAAGAGATAGAACAAACAAGTTTAAGTTCAAAGAATGAGAGCGCTGGA
CCAGAGAGCAGGGCGGACTGGTGTATTTCTCATAGGACTTATGACATTGGCAATAGAAAGGAGTTTGAAAGATTTAAGAAATTTATAAAA
GGTACATTGGGAGAGAGATATTGGTGGCTATGGATGGATATTGAGAGGTTAAAAGTTCTTAAGGATCCTGGAAGACATCAAAGACATCTT
GAGAAGATGAAAAAATGCTATCTAGTGAGCAATGGAGATTACTACCTTTCTGCAGAAATCTTATCAAAATTTAAACTGTTAGATGGATCA
CAGTGGAATGAAGAGCATTTAAGAAATATTCAGTCTGAAGTTTTAAAACCTTTACTTCTGTATTGGGCACCAAGATTCTGTGTTACTCAT
TCAGCCTCAACAAAATATGCTAGTGCTGAACTGAAATTCTGGCACCTCCGTCAAGCAAAACCAAGGAAGGATATTGACCCTTTTCCACAA
ATGGCAACCCTCTTGCCATTAAGACCCAAATCTTGCATTCCACAGATACCTGAGATCCAGAAAGAAGAATTCAGCTTATCACAACCTCCT
AAATCTCCCAATAAATCACCTGAAGTAAAAACAGCAACTCAAAAGCCTTGGAAGCGGGAGCTTTTGTATCCAGGTTCTTCTAAGGATGAT
GTGATTGAGAAAGGGTCAAAGTACATGTCAGAAAGCAGCAAAGTCATTCATTTAACATCTTTTACTGACATTTCTGAATGTCTCAAGCCC
CAGCTGGATAGAAGATACGCTTATACAGAAGAACCTAGGGTTAAAACCGTGTCAGATGTTGGTGCCTTGGGAGGATCTGACATGGAAAAT
TTGTTGCAATCTTTGTATGTAGAAAATAGAGCTGGATTCTTCTTTACTAAATTCTGCGAGCATTCAGGGAACAAGTTGTGGAAGAACAGT
GTGTACTTTTGGTTTGACCTGCAGGCTTATCATCAGCTTTTCTACCAAGAAACACTTCAGCCTTTTAAAGTATGCAAGCAAGCGCAATAT
CTTTTTGCCACATACGTTGCTCCTTCTGCCACTCTTGACATTGGACTCCAACAGGAAAAGAAAAAAGAAATTTATATGAAAATACAGCCA
CCATTTGAAGACCTTTTTGACACAGCAGAGGAATATATCCTTCTCCTCCTTCTTGAGCCATGGACAAAGATGGTAAAATCGGACCAAATT
GCTTATAAAAAGGTGGAGCTGGTGGAAGAAACTCGACAGTTAGACTCCACATACTTCAGAAAGCTACAGGCTTTGCATAAAGAGACATTT
TCCAAGAAAGCTGAGGACACCACTTGTGAAATTGGAACTGGCATTTTATCACTCTCTAACGTCTCTAAACGAACAGAATATTGGGATAAT
GTTCCTGCAGAATACAAGCATTTTAAGTTTAGTGATCTGCTTAACAACAAACTGGAGTTTGAACATTTCCGTCAGTTTCTTGAGACTCAT
TCTTCAAGCATGGATCTTATGTGCTGGACAGACATTGAGCAGTTCCGGAGAATAACTTACAGAGATCGAAATCAAAGGAAGGCAAAATCT
ATATACATTAAAAACAAATACCTTAATAAAAAATATTTCTTTGGACCCAACAGTCCAGCTTCTCTGTATCAGCAGAACCAGGTAATGCAT
TTAAGTGGTGGCTGGGGGAAGATTCTTCATGAGCAGCTTGATGCACCTGTTCTAGTTGAAATCCAGAAGCATGTGCAAAATAGGCTAGAA
AATGTATGGCTGCCATTGTTTCTTGCAAGTGAACAGTTTGCAGCACGTCAGAAGATAAAGGTACAGATGAAAGACATAGCAGAAGAGCTC
TTACTACAGAAGGCTGAAAAGAAAATCGGGGTCTGGAAGCCTGTGGAGAGTAAGTGGATCTCTTCATCTTGTAAAATCATTGCTTTTCGC
AAAGCATTATTGAATCCAGTTACTTCAAGACAATTTCAACGTTTTGTGGCTCTAAAAGGAGATTTATTGGAAAATGGTTTACTCTTTTGG
CAAGAAGTACAAAAATATAAGGACTTGTGCCATTCTCATTGTGATGAGTCTGTCATCCAGAAGAAGATTACAACTATTATCAACTGCTTT
ATTAATTCCAGTATTCCACCAGCTTTACAAATTGACATTCCAGTAGAGCAAGCCCAGAAGATTATTGAACACCGGAAGGAGTTAGGACCA
TATGTATTTAGAGAGGCACAGATGACAATTTTTGGGGTTCTGTTTAAATTCTGGCCTCAGTTCTGTGAGTTTAGGAAGAATTTAACAGAT
GAAAATATTATGAGTGTTTTAGAGAGAAGACAAGAATATAATAAGCAGAAAAAAAAATTGGCAGTCCTAGAAGACGAAAAATCTGGAAAG
GATGGAATCAAACAATATGCAAATACTTCAGTGCCTGCTATCAAAACTGCTTTACTCAGTGATTCCTTCCTAGGCCTCCAACCATATGGC
CGACAGCCAACCTGGTGCTACTCAAAGTATATAGAAGCCTTAGAACAGGAGAGAATTCTTCTTAAGATCCAAGAAGAACTAGAAAAAAAG
TTGTTTGCAGGCTTGCAACCTCTCACAAATTTTAAGGCTAGCTCTTCAACTATGTCTTTGAAAAAGAATATGTCTGCCCACAGCAGCCAG
AAGTGACAGCATTCTTGTGAATGTTTACATCCTGCTGCTGATAGGTTCAAGGAATTCTTTAAACCAGATTCTGCTGACATGAGAAGCTCC
AGTGATTTGTTTTTTTGAAGGTCTGTATCAGAGCAAGCCTAACATCTAAATAAAGTTTGATTCTGGATTTTCCAGGTGGGAAATAAATAA
AGAAAATTTGGCTTGTCTTACTCTCGCAGTTTTAAAATTATAGCTATTCTGTACACATGACATACAAGACTATAAGAACTGTTTAACTTA

>98290_98290_1_VPS13B-RGS22_VPS13B_chr8_100821758_ENST00000357162_RGS22_chr8_101092583_ENST00000360863_length(amino acids)=3924AA_BP=2698
MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELRIHVPWTKLGSEPVVITINTMECIL
KLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYT
VGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQ
LPMFIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQDEEQPQGWVSWAWSFVPAIVSYD
DGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRFGAFYMDY
LYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPEEVA
LLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQ
PSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLLLQA
IYQSWSHLGNVSSSAVIEALINEIFLSIGVKSKNPLPTLEGSIQNVELKYCSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSD
TKDLHSTKWLNESRKPESLLAPDLMAFTIQVPQYIDYCHNSGAVLLCSIQGLAVNIDPILYTWLIYQPQKRTSRHMQQQPVVAVPLVMPV
CRRKEDEVSIGSAPLAKQQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNISESCRSPEERMKEFIGIVWNAVKHLTLQLEVQSCCVFI
PNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISAGHKYMEPLQEIPFVIPRPILEEGDAFPWTISLHNFSIYTLLGKQ
VTLCLVEPMGCTSTLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDIMNKVWNKIQKRGNLNLSPTSPETMAGPV
PTSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEESPFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGTEVC
MVSELEDLSASIDVQDVYTKVKCKIESFNIDHYRSRPGEGWQSGHFEGVFLQCKEKSVTTTKLLDGTHQQHGFLSLTYTKAVTKNVRHKL
TSRNERRSFHKLSEGLMDGSPHFLHEILLSAQAFDIVLYFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYVNTSVIR
IFIPKTEEMQPTVEANQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRDPGSEIEDRQYQIDLQSINIGTAQWHQLK
PEKESVSGGVVTETERNSQNPALEWNMASSIRRHQERRAILTPVLTDFSVRITGAPAVIFTKVVSPENLHTEEILVCGHSLEVNITTNLD
FFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQKKVDIFDGGMAETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSRQ
SSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKSQEQKNNEKTDKSSLNLPEVDSDVAKPNQACISTVTAEDLLRSSISFPSGKKIGV
LSLESLHASTRSSARQALGITIVRQPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCIDPGKTLPEALD
YCTVWLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFTKLDQINLFLKKIKNAHSLAHSEETSAMSNTMVNKDDL
PVSKYYRGKLSKPKIHGDGVQKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPCLLASLSNLNGSLSVKATQKVPGIILGSSFL
LSINDFLLKTSLKERSRILIGPCCATANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVFWGQEHLNCLVLLHELLNGYLNEEGNFEVQ
VSEPVPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQDAESLKLPGVYEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDI
STADLGDVLQVPCSLEYWDELQKVFVAFREFNLSESKVCELQLPDINLVNDQKKLVSSDLWRIVLNSSQNGADDQSSASESGSQSTCDPL
VTPTALAACTRVDSCFTPWFVPSLCVSFQFAHLEFHLCHHLDQLGTAAPQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQE
IQFLAQADCKLLECRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNLGQHVVHSLNTAIQAWQQNKCPEVEELVFSHFVIC
NDTQETLRFGQVDTDENILLASLHSHQYSWRSHKSPQLLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGRTASLIIKVQQLNGVQKQT
FSEAIRFNADYGVFEVANDAPQFLEKQLKKILQNQQPRNPIYDVVRKGKNEVKPVQMNAPDEDETINVNYNIMCLSREEGIKWIKKERLP
AFLESDCYFEYRLAKLVSQVRWSKSGMNFTVGSNFSPWIVKKPPSLPPPATEEDNLVIMKKFYVSLGEASYTQTKDWFALAKQSQQTVST
FSLPCCVPYNKLKSPAISSVSENFIFDDGVHPRTKKDPSKTNKLISEFEEEEGEEEEVSVSLQDTPSQALLRVYLEKKQDVDESLTMHFS
TCEEFLSSYIYFILRGAIQQIVGKPVGETPDYINFNNITKVSFDDCFESIHGKNFLSELVQTTKERSEEIEQTSLSSKNESAGPESRADW
CISHRTYDIGNRKEFERFKKFIKGTLGERYWWLWMDIERLKVLKDPGRHQRHLEKMKKCYLVSNGDYYLSAEILSKFKLLDGSQWNEEHL
RNIQSEVLKPLLLYWAPRFCVTHSASTKYASAELKFWHLRQAKPRKDIDPFPQMATLLPLRPKSCIPQIPEIQKEEFSLSQPPKSPNKSP
EVKTATQKPWKRELLYPGSSKDDVIEKGSKYMSESSKVIHLTSFTDISECLKPQLDRRYAYTEEPRVKTVSDVGALGGSDMENLLQSLYV
ENRAGFFFTKFCEHSGNKLWKNSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYMKIQPPFEDLFD
TAEEYILLLLLEPWTKMVKSDQIAYKKVELVEETRQLDSTYFRKLQALHKETFSKKAEDTTCEIGTGILSLSNVSKRTEYWDNVPAEYKH
FKFSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKNKYLNKKYFFGPNSPASLYQQNQVMHLSGGWGK
ILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQFAARQKIKVQMKDIAEELLLQKAEKKIGVWKPVESKWISSSCKIIAFRKALLNPV
TSRQFQRFVALKGDLLENGLLFWQEVQKYKDLCHSHCDESVIQKKITTIINCFINSSIPPALQIDIPVEQAQKIIEHRKELGPYVFREAQ
MTIFGVLFKFWPQFCEFRKNLTDENIMSVLERRQEYNKQKKKLAVLEDEKSGKDGIKQYANTSVPAIKTALLSDSFLGLQPYGRQPTWCY

--------------------------------------------------------------
>98290_98290_2_VPS13B-RGS22_VPS13B_chr8_100821758_ENST00000358544_RGS22_chr8_101092583_ENST00000360863_length(transcript)=12267nt_BP=8283nt
GGCGCGGTACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTCTTCCGAC
TTCGACTCCTTACCTTAAAAGATGCTGGAGTCATATGTAACTCCAATTTTAATGAGCTATGTGAATCGCTACATCAAGAACTTAAAGCCG
TCGGATCTACAGCTTTCACTATGGGGTGGAGACGTGGTACTCAGCAAGCTCGAGTTAAAGTTGGATGTGCTGGAACAGGAACTGAAATTA
CCATTCACTTTTTTAAGTGGACATATTCATGAATTGAGGATTCATGTACCATGGACAAAACTGGGTTCAGAACCAGTGGTAATTACCATC
AATACTATGGAATGCATTTTGAAACTTAAGGATGGGATACAGGATGACCATGAAAGCTGTGGTTCTAATTCTACCAACCGTAGTACTGCT
GAGAGCACAAAATCATCAATCAAACCGCGGAGAATGCAGCAGGCTGCTCCTACAGATCCTGACTTACCACCAGGTTATGTGCAGAGTCTG
ATTAGACGAGTTGTAAATAATGTAAACATTGTGATAAATAATCTCATACTAAAATATGTTGAAGATGATATCGTCCTTTCCGTCAATATC
ACTTCTGCAGAATGTTATACAGTAGGTGAATTATGGGATCGTGCATTCATGGATATTTCTGCAACTGATTTGGTGCTGAGAAAGGTTATC
AATTTTTCTGACTGTACAGTTTGTCTTGATAAACGGAATGCCAGTGGTAAAATAGAATTTTACCAGGATCCTTTATTATACAAATGTTCC
TTCAGAACTCGTCTTCATTTTACATATGAAAACCTAAATTCCAAGATGCCATCTGTTATTAAAATTCATACTTTAGTGGAAAGTTTGAAA
CTTTCTATCACAGATCAACAACTGCCTATGTTTATTCGTATAATGCAACTTGGAATTGCTCTTTACTATGGAGAAATAGGCAATTTTAAA
GAAGGCGAAATAGAGGACCTTACTTGTCATAATAAAGATATGCTAGGAAACATTACAGGTTCTGAAGATGAAACAAGAATAGATATGCAA
TATCCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAGCAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTG
CCTGCAATTGTGAGTTATGACGATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCACAGACTTTG
AAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACTTTCAAACTCACAGAAATGCAAGTTGAGAGTAGTTATTAC
AGTCCACAGAAAGTAAAATCTAAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAGGCCCTTATGATGGGAGAACCTTTCTTT
GATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAAAGGAATTATGGGTGTTAAAGATTTTGAAGAGAATATGAATAGAAGT
GAAACTGAAGCCTGTTTCTTCATTTGTGGTGACAATTTGAGTACGAAAGGTTTCACATACCTTACAAATTCATTGTTTGATTACCGAAGC
CCAGAAAATAATGGTACTCGCGCAGAATTTATCTTGGATTCAACTCATCATAAGGAGACATACACTGAGATAGCTGGAATGCAACGGTTT
GGGGCTTTTTATATGGATTACCTGTATACAATGGAGAACACTAGTGGCAAAGGTTCCACAAATCAACAAGACTTTTCTTCAGGGAAAAGT
GAAGATTTGGGAACAGTTCAGGAGAAGTCCACCAAAAGCCTTGTTATAGGTCCTCTTGATTTTCGTTTGGATAGCAGTGCGGTGCATAGG
ATTTTGAAAATGATTGTGTGTGCCTTGGAACATGAATATGAACCATATAGCAGGCTAAAATCAGATATTAAGGATGAAAATGAAACAATA
CTGAATCCTGAAGAGGTGGCTCTTCTGGAGGAATATATTCCTACTCGACATACAAGTGTTACTCTCCTCAAATGTACCTGCACAATTTCC
ATGGCTGAATTCAACTTGCTGGACCATTTACTACCTGTCATTATGGGAGAAAAGAACTCAAGTAACTTCATGAATACTACAAACTTCCAG
TCTCTTCGGCCTTTGCCATCCATTCGAATATTGGTGGATAAAATTAATCTGGAACATTCAGTGCCAATGTATGCTGAACAGTTGGTGCAT
GTGGTCAGCAGCCTTACTCAACCTTCTGATAACCTGCTTCATTATTGTTATGTACACTGCTATCTTAAGATATTTGGTTTCCAGGCAGGA
CTGACGTCTTTGGATTGCAGTGGATCTTACTGCTTACCTGTACCAGTTATTCCCTCTTTCAGCACTGCTCTTTATGGGAAACTTCTGAAA
CTCCCCACATGCTGGACCAAAAGATCTCAGATTGCTATAACTGAAGGTATATTTGAACTTCCAAATCTCACAATTCAAGCTACAAGAGCA
CAGACACTTCTCTTGCAAGCAATATATCAAAGTTGGTCTCATCTTGGAAATGTCAGCTCTTCCGCAGTGATTGAAGCTTTGATAAATGAA
ATCTTCCTAAGTATAGGTGTGAAATCTAAGAATCCCCTGCCAACTCTTGAGGGCTCAATCCAGAATGTTGAATTGAAGTACTGCAGCACA
TCATTGGTCAAATGTGCCTCTGGGACCATGGGATCAATAAAAATTTGTGCCAAAGCCCCAGTTGATAGTGGAAAAGAGAAGTTGATTCCC
TTGCTTCAGGGTCCTTCTGACACTAAAGACCTTCATAGCACCAAGTGGCTCAATGAGAGTAGAAAGCCAGAGTCTCTCTTAGCTCCAGAT
TTGATGGCCTTCACAATCCAAGTTCCACAATATATTGACTACTGCCACAATTCCGGTGCTGTACTTCTTTGCAGTATACAAGGACTAGCA
GTTAATATTGACCCAATCTTATATACGTGGCTCATCTATCAGCCTCAGAAACGAACAAGTAGACATATGCAACAGCAGCCTGTGGTAGCT
GTTCCTCTTGTTATGCCAGTTTGTAGAAGGAAAGAGGATGAGGTGTCTATTGGAAGTGCCCCCTTGGCAAAGCAGCAATCATATCAGGCC
TCTGAATATGCCAGCAGCCCTGTAAAAACAAAAACGGTAACAGAATCCCGCCCATTGTCAGTTCCTGTTAAAGCCATGTTGAATATATCT
GAAAGCTGTAGAAGTCCTGAAGAAAGAATGAAGGAATTTATTGGAATTGTTTGGAATGCAGTGAAGCATCTCACACTACAGCTTGAAGTA
CAATCTTGTTGTGTGTTTATTCCAAATGATAGCCTGCCTTCCCCAAGTACAATTGTATCTGGTGACATTCCTGGAACAGTAAGAAGTTGG
TACCATGGACAAACCAGCATGCCGGGAACACTTGTCCTCTGTTTGCCTCAAATAAAGATTATTAGTGCTGGGCACAAGTATATGGAACCT
CTGCAGGAGATTCCATTTGTTATCCCACGACCCATCCTTGAAGAAGGTGATGCTTTTCCTTGGACGATCAGCTTGCATAATTTCAGCATA
TATACCCTTCTTGGAAAACAAGTGACACTTTGCCTAGTGGAACCTATGGGTTGCACCTCCACTCTAGCTGTCACGTCTCAAAAACTGCTT
GCTACGGGACCTGATACACGACATTCATTTGTTGTCTGTCTCCATGTTGACCTAGAGTCACTAGAGATAAAATGCTCTAATCCCCAGGTC
CAGCTCTTCTATGAACTAACTGATATCATGAATAAGGTCTGGAACAAGATTCAGAAGAGAGGCAATCTCAACCTATCTCCAACCTCTCCA
GAGACCATGGCAGGGCCTGTTCCTACTTCTCCAGTTAGAAGCAGTATAGGCACAGCTCCTCCAGATACCAGCACATGCAGCCCATCTGCT
GACATTGGGACTACTACTGAGGGAGATTCTATACAAGCAGGTGAGGAATCACCATTCTCAGATTCTGTGACCTTGGAACAAACTACAAGT
AATATTGGAGGAACCAGTGGACGTGTTAGTTTATGGATGCAGTGGGTGCTTCCCAAAATTACTATAAAGCTCTTTGCTCCAGATCCTGAA
AATAAAGGCACAGAGGTTTGTATGGTCAGTGAACTAGAAGATCTCAGTGCTTCCATAGATGTCCAGGATGTATATACCAAAGTGAAATGT
AAAATAGAGAGTTTCAATATTGATCACTATAGAAGCAGCCTTGGGGAAGAGTGTTGGTCTTTGGGGCAATGTGGAGGTGTCTTCCTTTCC
TGTACTGACAAGCTGAACAGACGCACCTTGTTGGTTCGACCCATCAGCAAGCAGGACCCTTTCAGTAATTGCTCTGGCTTCTTTCCTTCT
ACAACTACAAAACTTCTAGATGGCACTCATCAGCAGCATGGATTCCTCTCTCTGACATACACAAAAGCTGTAACAAAAAATGTCCGCCAC
AAGTTAACATCAAGAAATGAGCGAAGAAGTTTTCATAAGTTATCTGAAGGCCTAATGGATGGTTCTCCTCATTTTCTTCATGAAATTCTT
CTTTCAGCACAAGCTTTTGATATTGTTCTTTATTTTCCTTTACTTAATGCCATTGCAAGTATATTTCAAGCAAAACTACCAAAGACCCAA
AAAGAGAAAAGAAAATCTCCTGGTCAGCCCATGAGGACCCATACACTGACATCCCGCAATTTACCTTTGATTTATGTCAACACAAGTGTA
ATCAGAATTTTTATTCCAAAAACAGAAGAAATGCAGCCAACTGTTGAAGCTAATCAGGCAGCAAAAGAAGACACTGTGGTTTTGAAGATT
GGCTCTGTTGCCATGGCTCCCCAGGCTGACAATCCCCTTGGCAGATCTGTCCTTAGGAAAGATATTTACCAGAGAGCCTTGAACTTAGGA
ATTCTTCGAGATCCTGGATCAGAAATCGAAGACAGACAATACCAAATAGATCTGCAGTCCATCAATATTGGTACTGCACAGTGGCATCAA
CTAAAACCAGAGAAGGAAAGTGTCTCAGGAGGGGTGGTAACAGAGACTGAAAGGAATTCTCAAAATCCAGCCCTTGAGTGGAATATGGCC
AGCAGCATACGGCGGCATCAAGAAAGGAGAGCAATTTTGACCCCCGTTTTGACAGATTTTTCTGTCCGAATAACTGGAGCACCTGCTGTC
ATTTTCACCAAAGTAGTTTCTCCAGAAAATTTGCATACTGAGGAGATTTTAGTGTGTGGCCATTCCTTAGAAGTGAATATAACCACAAAC
CTGGACTTCTTCCTAAGTGTGGCTCAAGTTCAACTCTTACATCAGTTAATAGTAGCAAATATGACTGGACTGGAACCATCAAACAAGGCT
GCAGAGATCTCTAAACAAGAACAGAAAAAAGTGGATATATTTGATGGAGGCATGGCTGAAACCTCATCTCGCTACAGTGGTGCTCAGGAT
AGTGGAATTGGCAGTGACAGTGTTAAAATCAGAATAGTGCAAATAGAGCAGCACAGTGGTGCCAGTCAGCATCGCATTGCCCGTCCCTCA
CGCCAGTCATCAATTGTAAAAAATCTAAATTTTATTCCCTTTGACATATTTATTACTGCAAGTAGAATCTCACTAATGACCTATTCCTGT
ATGGCCTTATCCAAATCGAAATCACAAGAACAGAAGAATAATGAAAAAACAGACAAGAGTTCATTAAATCTCCCAGAAGTTGATTCAGAT
GTTGCTAAGCCCAACCAGGCATGTATTTCCACGGTGACAGCAGAAGATCTCTTAAGGAGCAGCATTTCTTTTCCTTCAGGGAAAAAAATA
GGGGTCCTCTCTCTTGAAAGTCTTCATGCATCCACAAGGTCATCTGCTAGACAAGCACTTGGTATAACTATTGTTCGGCAGCCTGGTCGA
AGAGGAACTGGTGACTTACAGCTAGAGCCTTTTCTGTACTTTATTGTGTCCCAGCCTTCCTTGCTTCTGAGTTGTCACCACAGAAAGCAG
CGAGTGGAAGTATCCATTTTTGATGCTGTGCTTAAAGGGGTGGCCTCTGATTACAAATGTATAGATCCTGGGAAGACTCTGCCTGAAGCC
CTTGATTATTGCACTGTTTGGCTACAGACAGTGCCTGGAGAAATAGACAGCAAAAGTGGTATTCCACCTTCCTTTATAACACTACAGATT
AAAGACTTTCTGAATGGACCAGCGGATGTCAATTTGGATATATCAAAGCCTTTGAAAGCAAACCTGAGTTTCACCAAACTGGATCAGATA
AACCTTTTTTTAAAGAAGATAAAAAATGCACACAGTTTGGCACATAGTGAAGAGACTTCAGCCATGTCCAACACCATGGTGAATAAGGAT
GATCTTCCAGTCTCCAAATATTACCGTGGAAAGTTGTCTAAACCCAAAATTCATGGTGATGGAGTGCAAAAGATTTCAGCTCAAGAAAAC
ATGTGGAGAGCTGTTTCCTGCTTTCAAAAAATTTCTGTTCAAACTACTCAGATTGTGATCTCCATGGAAACTGTACCCCATACCAGCAAA
CCATGCCTGTTAGCATCTCTCTCAAACCTCAATGGAAGCCTTAGTGTCAAGGCAACACAAAAAGTACCTGGCATAATTCTTGGGTCATCA
TTTCTACTCAGTATAAACGATTTTCTCCTTAAAACAAGTCTCAAAGAAAGAAGCCGCATTCTGATAGGACCATGTTGTGCTACTGCCAAT
CTGGAAGCTAAGTGGTGTAAACACAGCGGGAATCCAGGCCCAGAACAATCCATACCAAAAATATCCATTGACTTAAGAGGAGGTCTACTA
CAGGTCTTCTGGGGTCAAGAACATTTGAATTGTTTAGTTCTTCTACATGAATTACTCAATGGATACCTTAATGAGGAGGGAAATTTTGAA
GTACAAGTTTCTGAACCAGTGCCTCAAATGTCATCTCCTGTGGAAAAGAATCAGACATTTAAAAGTGAACAAAGTTCAGATGACCTACGG
ACAGGTCTATTTCAGTATGTACAGGATGCTGAATCTTTGAAATTGCCTGGGGTCTATGAAGTCTTATTTTATAATGAAACTGAAGATTGC
CCAGGGATGATGTTATGGAGATATCCAGAACCTAGAGTACTCACCCTTGTACGAATAACTCCTGTACCTTTTAACACCACAGAGGATCCA
GATATTAGCACAGCAGACCTTGGTGATGTGCTACAGGTTCCTTGTAGCTTGGAATACTGGGATGAACTCCAGAAGGTTTTTGTTGCATTT
AGAGAATTTAATCTGTCTGAAAGCAAAGTTTGTGAACTGCAGTTGCCGGATATCAATCTCGTGAATGACCAGAAGAAATTAGTATCTTCA
GATCTTTGGAGAATTGTCTTGAACAGCAGTCAAAATGGAGCTGATGACCAAAGCTCTGCAAGTGAGTCTGGTTCTCAAAGCACTTGTGAT
CCACTTGTGACTCCAACAGCCCTGGCTGCCTGTACCAGAGTTGACTCCTGCTTTACCCCATGGTTTGTCCCATCCCTTTGCGTTTCTTTC
CAGTTTGCTCACCTGGAATTCCATCTTTGTCATCACCTTGACCAACTAGGCACAGCTGCACCACAGTACCTACAGCCATTTGTTTCCGAC
AGAAATATGCCATCTGAACTAGAATACATGATTGTTTCCTTCAGAGAACCACACATGTATCTTCGACAGTGGAATAATGGTTCTGTCTGT
CAGGAGATCCAGTTCTTAGCTCAAGCAGACTGTAAACTTCTAGAGTGCAGAAATGTCACTATGCAAAGTGTGGTGAAACCCTTCAGCATC
TTCGGGCAGATGGCAGTTTCCAGCGATGTAGTGGAAAAGCTGCTTGACTGCACCGTGATAGTTGATTCTGTATTTGTAAACCTTGGACAG
CATGTAGTCCATTCACTAAACACTGCAATACAAGCTTGGCAACAGAACAAATGCCCTGAGGTAGAGGAGTTGGTCTTCAGCCATTTTGTG
ATCTGTAATGACACACAGGAGACACTGCGGTTTGGCCAGGTGGATACTGATGAAAATATTCTGCTGGCGAGTCTCCACAGTCACCAGTAC
AGCTGGCGCTCTCACAAATCCCCACAGCTGTTACACATCTGTATTGAAGGTTGGGGCAACTGGCGTTGGTCAGAGCCTTTCAGTGTGGAC
CATGCCGGGACTTTTATTAGAACAATTCAGTACAGGGGTCGAACTGCTTCTCTCATCATCAAGGTTCAGCAACTCAATGGAGTACAAAAA
CAGACCTTTTCAGAGGCAATTAGATTTAATGCAGATTATGGAGTTTTTGAAGTAGCTAATGATGCTCCACAATTTCTGGAAAAACAACTG
AAAAAAATTCTACAAAACCAGCAACCTCGAAATCCCATTTATGATGTTGTAAGGAAAGGAAAGAATGAGGTTAAACCTGTTCAAATGAAT
GCCCCCGATGAAGATGAGACCATTAATGTCAACTACAATATTATGTGTCTCAGTCGTGAAGAAGGTATTAAGTGGATCAAAAAAGAAAGA
CTTCCAGCATTTCTGGAAAGTGATTGTTACTTTGAATACAGGTTAGCCAAATTGGTCTCACAAGTAAGATGGAGCAAGTCCGGCATGAAT
TTCACAGTAGGATCAAATTTTTCTCCCTGGATCGTGAAAAAACCACCCAGTCTACCACCTCCTGCCACTGAAGAAGATAATCTTGTAATT
ATGAAAAAGTTCTATGTATCACTTGGTGAGGCTTCCTATACTCAAACAAAAGATTGGTTTGCATTAGCAAAACAAAGTCAGCAAACAGTA
TCAACCTTTTCGTTACCCTGTTGTGTACCCTACAACAAACTTAAATCACCAGCTATTTCATCTGTTTCTGAGAATTTTATCTTTGATGAT
GGAGTTCACCCTAGGACAAAAAAGGACCCATCTAAAACCAACAAATTGATTTCTGAATTTGAAGAAGAAGAAGGAGAAGAAGAAGAGGTG
TCTGTATCTCTACAAGACACTCCTTCTCAAGCTCTTCTGAGAGTATACCTTGAAAAGAAACAGGATGTTGATGAAAGCCTGACAATGCAT
TTCTCAACATGTGAAGAATTTTTAAGCTCCTATATATACTTTATTTTGAGAGGAGCAATTCAGCAAATTGTTGGAAAGCCAGTTGGAGAA
ACCCCAGACTATATAAACTTCAACAATATAACAAAAGTGTCATTTGATGATTGTTTTGAGTCTATTCATGGCAAGAATTTTTTAAGTGAA
TTAGTTCAAACTACAAAGGAGAGGTCAGAAGAGATAGAACAAACAAGTTTAAGTTCAAAGAATGAGAGCGCTGGACCAGAGAGCAGGGCG
GACTGGTGTATTTCTCATAGGACTTATGACATTGGCAATAGAAAGGAGTTTGAAAGATTTAAGAAATTTATAAAAGGTACATTGGGAGAG
AGATATTGGTGGCTATGGATGGATATTGAGAGGTTAAAAGTTCTTAAGGATCCTGGAAGACATCAAAGACATCTTGAGAAGATGAAAAAA
TGCTATCTAGTGAGCAATGGAGATTACTACCTTTCTGCAGAAATCTTATCAAAATTTAAACTGTTAGATGGATCACAGTGGAATGAAGAG
CATTTAAGAAATATTCAGTCTGAAGTTTTAAAACCTTTACTTCTGTATTGGGCACCAAGATTCTGTGTTACTCATTCAGCCTCAACAAAA
TATGCTAGTGCTGAACTGAAATTCTGGCACCTCCGTCAAGCAAAACCAAGGAAGGATATTGACCCTTTTCCACAAATGGCAACCCTCTTG
CCATTAAGACCCAAATCTTGCATTCCACAGATACCTGAGATCCAGAAAGAAGAATTCAGCTTATCACAACCTCCTAAATCTCCCAATAAA
TCACCTGAAGTAAAAACAGCAACTCAAAAGCCTTGGAAGCGGGAGCTTTTGTATCCAGGTTCTTCTAAGGATGATGTGATTGAGAAAGGG
TCAAAGTACATGTCAGAAAGCAGCAAAGTCATTCATTTAACATCTTTTACTGACATTTCTGAATGTCTCAAGCCCCAGCTGGATAGAAGA
TACGCTTATACAGAAGAACCTAGGGTTAAAACCGTGTCAGATGTTGGTGCCTTGGGAGGATCTGACATGGAAAATTTGTTGCAATCTTTG
TATGTAGAAAATAGAGCTGGATTCTTCTTTACTAAATTCTGCGAGCATTCAGGGAACAAGTTGTGGAAGAACAGTGTGTACTTTTGGTTT
GACCTGCAGGCTTATCATCAGCTTTTCTACCAAGAAACACTTCAGCCTTTTAAAGTATGCAAGCAAGCGCAATATCTTTTTGCCACATAC
GTTGCTCCTTCTGCCACTCTTGACATTGGACTCCAACAGGAAAAGAAAAAAGAAATTTATATGAAAATACAGCCACCATTTGAAGACCTT
TTTGACACAGCAGAGGAATATATCCTTCTCCTCCTTCTTGAGCCATGGACAAAGATGGTAAAATCGGACCAAATTGCTTATAAAAAGGTG
GAGCTGGTGGAAGAAACTCGACAGTTAGACTCCACATACTTCAGAAAGCTACAGGCTTTGCATAAAGAGACATTTTCCAAGAAAGCTGAG
GACACCACTTGTGAAATTGGAACTGGCATTTTATCACTCTCTAACGTCTCTAAACGAACAGAATATTGGGATAATGTTCCTGCAGAATAC
AAGCATTTTAAGTTTAGTGATCTGCTTAACAACAAACTGGAGTTTGAACATTTCCGTCAGTTTCTTGAGACTCATTCTTCAAGCATGGAT
CTTATGTGCTGGACAGACATTGAGCAGTTCCGGAGAATAACTTACAGAGATCGAAATCAAAGGAAGGCAAAATCTATATACATTAAAAAC
AAATACCTTAATAAAAAATATTTCTTTGGACCCAACAGTCCAGCTTCTCTGTATCAGCAGAACCAGGTAATGCATTTAAGTGGTGGCTGG
GGGAAGATTCTTCATGAGCAGCTTGATGCACCTGTTCTAGTTGAAATCCAGAAGCATGTGCAAAATAGGCTAGAAAATGTATGGCTGCCA
TTGTTTCTTGCAAGTGAACAGTTTGCAGCACGTCAGAAGATAAAGGTACAGATGAAAGACATAGCAGAAGAGCTCTTACTACAGAAGGCT
GAAAAGAAAATCGGGGTCTGGAAGCCTGTGGAGAGTAAGTGGATCTCTTCATCTTGTAAAATCATTGCTTTTCGCAAAGCATTATTGAAT
CCAGTTACTTCAAGACAATTTCAACGTTTTGTGGCTCTAAAAGGAGATTTATTGGAAAATGGTTTACTCTTTTGGCAAGAAGTACAAAAA
TATAAGGACTTGTGCCATTCTCATTGTGATGAGTCTGTCATCCAGAAGAAGATTACAACTATTATCAACTGCTTTATTAATTCCAGTATT
CCACCAGCTTTACAAATTGACATTCCAGTAGAGCAAGCCCAGAAGATTATTGAACACCGGAAGGAGTTAGGACCATATGTATTTAGAGAG
GCACAGATGACAATTTTTGGGGTTCTGTTTAAATTCTGGCCTCAGTTCTGTGAGTTTAGGAAGAATTTAACAGATGAAAATATTATGAGT
GTTTTAGAGAGAAGACAAGAATATAATAAGCAGAAAAAAAAATTGGCAGTCCTAGAAGACGAAAAATCTGGAAAGGATGGAATCAAACAA
TATGCAAATACTTCAGTGCCTGCTATCAAAACTGCTTTACTCAGTGATTCCTTCCTAGGCCTCCAACCATATGGCCGACAGCCAACCTGG
TGCTACTCAAAGTATATAGAAGCCTTAGAACAGGAGAGAATTCTTCTTAAGATCCAAGAAGAACTAGAAAAAAAGTTGTTTGCAGGCTTG
CAACCTCTCACAAATTTTAAGGCTAGCTCTTCAACTATGTCTTTGAAAAAGAATATGTCTGCCCACAGCAGCCAGAAGTGACAGCATTCT
TGTGAATGTTTACATCCTGCTGCTGATAGGTTCAAGGAATTCTTTAAACCAGATTCTGCTGACATGAGAAGCTCCAGTGATTTGTTTTTT
TGAAGGTCTGTATCAGAGCAAGCCTAACATCTAAATAAAGTTTGATTCTGGATTTTCCAGGTGGGAAATAAATAAAGAAAATTTGGCTTG
TCTTACTCTCGCAGTTTTAAAATTATAGCTATTCTGTACACATGACATACAAGACTATAAGAACTGTTTAACTTATTTAGAATAAAACAA

>98290_98290_2_VPS13B-RGS22_VPS13B_chr8_100821758_ENST00000358544_RGS22_chr8_101092583_ENST00000360863_length(amino acids)=3949AA_BP=2723
MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELRIHVPWTKLGSEPVVITINTMECIL
KLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYT
VGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQ
LPMFIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQDEEQPQGWVSWAWSFVPAIVSYD
DGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRFGAFYMDY
LYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPEEVA
LLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQ
PSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLLLQA
IYQSWSHLGNVSSSAVIEALINEIFLSIGVKSKNPLPTLEGSIQNVELKYCSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSD
TKDLHSTKWLNESRKPESLLAPDLMAFTIQVPQYIDYCHNSGAVLLCSIQGLAVNIDPILYTWLIYQPQKRTSRHMQQQPVVAVPLVMPV
CRRKEDEVSIGSAPLAKQQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNISESCRSPEERMKEFIGIVWNAVKHLTLQLEVQSCCVFI
PNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISAGHKYMEPLQEIPFVIPRPILEEGDAFPWTISLHNFSIYTLLGKQ
VTLCLVEPMGCTSTLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDIMNKVWNKIQKRGNLNLSPTSPETMAGPV
PTSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEESPFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGTEVC
MVSELEDLSASIDVQDVYTKVKCKIESFNIDHYRSSLGEECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFSNCSGFFPSTTTKLLD
GTHQQHGFLSLTYTKAVTKNVRHKLTSRNERRSFHKLSEGLMDGSPHFLHEILLSAQAFDIVLYFPLLNAIASIFQAKLPKTQKEKRKSP
GQPMRTHTLTSRNLPLIYVNTSVIRIFIPKTEEMQPTVEANQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRDPGS
EIEDRQYQIDLQSINIGTAQWHQLKPEKESVSGGVVTETERNSQNPALEWNMASSIRRHQERRAILTPVLTDFSVRITGAPAVIFTKVVS
PENLHTEEILVCGHSLEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQKKVDIFDGGMAETSSRYSGAQDSGIGSDS
VKIRIVQIEQHSGASQHRIARPSRQSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKSQEQKNNEKTDKSSLNLPEVDSDVAKPNQA
CISTVTAEDLLRSSISFPSGKKIGVLSLESLHASTRSSARQALGITIVRQPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIF
DAVLKGVASDYKCIDPGKTLPEALDYCTVWLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFTKLDQINLFLKKI
KNAHSLAHSEETSAMSNTMVNKDDLPVSKYYRGKLSKPKIHGDGVQKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPCLLASL
SNLNGSLSVKATQKVPGIILGSSFLLSINDFLLKTSLKERSRILIGPCCATANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVFWGQE
HLNCLVLLHELLNGYLNEEGNFEVQVSEPVPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQDAESLKLPGVYEVLFYNETEDCPGMMLWR
YPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQVPCSLEYWDELQKVFVAFREFNLSESKVCELQLPDINLVNDQKKLVSSDLWRIVL
NSSQNGADDQSSASESGSQSTCDPLVTPTALAACTRVDSCFTPWFVPSLCVSFQFAHLEFHLCHHLDQLGTAAPQYLQPFVSDRNMPSEL
EYMIVSFREPHMYLRQWNNGSVCQEIQFLAQADCKLLECRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNLGQHVVHSLN
TAIQAWQQNKCPEVEELVFSHFVICNDTQETLRFGQVDTDENILLASLHSHQYSWRSHKSPQLLHICIEGWGNWRWSEPFSVDHAGTFIR
TIQYRGRTASLIIKVQQLNGVQKQTFSEAIRFNADYGVFEVANDAPQFLEKQLKKILQNQQPRNPIYDVVRKGKNEVKPVQMNAPDEDET
INVNYNIMCLSREEGIKWIKKERLPAFLESDCYFEYRLAKLVSQVRWSKSGMNFTVGSNFSPWIVKKPPSLPPPATEEDNLVIMKKFYVS
LGEASYTQTKDWFALAKQSQQTVSTFSLPCCVPYNKLKSPAISSVSENFIFDDGVHPRTKKDPSKTNKLISEFEEEEGEEEEVSVSLQDT
PSQALLRVYLEKKQDVDESLTMHFSTCEEFLSSYIYFILRGAIQQIVGKPVGETPDYINFNNITKVSFDDCFESIHGKNFLSELVQTTKE
RSEEIEQTSLSSKNESAGPESRADWCISHRTYDIGNRKEFERFKKFIKGTLGERYWWLWMDIERLKVLKDPGRHQRHLEKMKKCYLVSNG
DYYLSAEILSKFKLLDGSQWNEEHLRNIQSEVLKPLLLYWAPRFCVTHSASTKYASAELKFWHLRQAKPRKDIDPFPQMATLLPLRPKSC
IPQIPEIQKEEFSLSQPPKSPNKSPEVKTATQKPWKRELLYPGSSKDDVIEKGSKYMSESSKVIHLTSFTDISECLKPQLDRRYAYTEEP
RVKTVSDVGALGGSDMENLLQSLYVENRAGFFFTKFCEHSGNKLWKNSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYVAPSATL
DIGLQQEKKKEIYMKIQPPFEDLFDTAEEYILLLLLEPWTKMVKSDQIAYKKVELVEETRQLDSTYFRKLQALHKETFSKKAEDTTCEIG
TGILSLSNVSKRTEYWDNVPAEYKHFKFSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKNKYLNKKY
FFGPNSPASLYQQNQVMHLSGGWGKILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQFAARQKIKVQMKDIAEELLLQKAEKKIGVW
KPVESKWISSSCKIIAFRKALLNPVTSRQFQRFVALKGDLLENGLLFWQEVQKYKDLCHSHCDESVIQKKITTIINCFINSSIPPALQID
IPVEQAQKIIEHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDENIMSVLERRQEYNKQKKKLAVLEDEKSGKDGIKQYANTSVP

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Fusion Gene PPI Analysis for VPS13B-RGS22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VPS13B-RGS22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VPS13B-RGS22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource