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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VPS13B-WAPAL (FusionGDB2 ID:98300)

Fusion Gene Summary for VPS13B-WAPAL

check button Fusion gene summary
Fusion gene informationFusion gene name: VPS13B-WAPAL
Fusion gene ID: 98300
HgeneTgene
Gene symbol

VPS13B

WAPAL

Gene ID

157680

23063

Gene namevacuolar protein sorting 13 homolog BWAPL cohesin release factor
SynonymsCHS1|COH1FOE|KIAA0261|WAPAL
Cytomap

8q22.2

10q23.2

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 13Bwings apart-like protein homologfriend of EBNA2 (Epstein-Barr virus nuclear protein 2)friend of EBNA2 protein
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000395996, ENST00000357162, 
ENST00000358544, ENST00000355155, 
ENST00000441350, ENST00000521932, 
ENST00000298767, ENST00000263070, 
ENST00000372075, ENST00000484070, 
Fusion gene scores* DoF score43 X 36 X 17=263164 X 3 X 4=48
# samples 505
** MAII scorelog2(50/26316*10)=-5.71786831273266
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VPS13B [Title/Abstract] AND WAPAL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVPS13B(100874174)-WAPAL(88260500), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across VPS13B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WAPAL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A27NVPS13Bchr8

100874174

+WAPALchr10

88260500

-


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Fusion Gene ORF analysis for VPS13B-WAPAL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000395996ENST00000298767VPS13Bchr8

100874174

+WAPALchr10

88260500

-
3UTR-intronENST00000395996ENST00000263070VPS13Bchr8

100874174

+WAPALchr10

88260500

-
3UTR-intronENST00000395996ENST00000372075VPS13Bchr8

100874174

+WAPALchr10

88260500

-
3UTR-intronENST00000395996ENST00000484070VPS13Bchr8

100874174

+WAPALchr10

88260500

-
5CDS-intronENST00000357162ENST00000263070VPS13Bchr8

100874174

+WAPALchr10

88260500

-
5CDS-intronENST00000357162ENST00000372075VPS13Bchr8

100874174

+WAPALchr10

88260500

-
5CDS-intronENST00000357162ENST00000484070VPS13Bchr8

100874174

+WAPALchr10

88260500

-
5CDS-intronENST00000358544ENST00000263070VPS13Bchr8

100874174

+WAPALchr10

88260500

-
5CDS-intronENST00000358544ENST00000372075VPS13Bchr8

100874174

+WAPALchr10

88260500

-
5CDS-intronENST00000358544ENST00000484070VPS13Bchr8

100874174

+WAPALchr10

88260500

-
In-frameENST00000357162ENST00000298767VPS13Bchr8

100874174

+WAPALchr10

88260500

-
In-frameENST00000358544ENST00000298767VPS13Bchr8

100874174

+WAPALchr10

88260500

-
intron-3CDSENST00000355155ENST00000298767VPS13Bchr8

100874174

+WAPALchr10

88260500

-
intron-3CDSENST00000441350ENST00000298767VPS13Bchr8

100874174

+WAPALchr10

88260500

-
intron-3CDSENST00000521932ENST00000298767VPS13Bchr8

100874174

+WAPALchr10

88260500

-
intron-intronENST00000355155ENST00000263070VPS13Bchr8

100874174

+WAPALchr10

88260500

-
intron-intronENST00000355155ENST00000372075VPS13Bchr8

100874174

+WAPALchr10

88260500

-
intron-intronENST00000355155ENST00000484070VPS13Bchr8

100874174

+WAPALchr10

88260500

-
intron-intronENST00000441350ENST00000263070VPS13Bchr8

100874174

+WAPALchr10

88260500

-
intron-intronENST00000441350ENST00000372075VPS13Bchr8

100874174

+WAPALchr10

88260500

-
intron-intronENST00000441350ENST00000484070VPS13Bchr8

100874174

+WAPALchr10

88260500

-
intron-intronENST00000521932ENST00000263070VPS13Bchr8

100874174

+WAPALchr10

88260500

-
intron-intronENST00000521932ENST00000372075VPS13Bchr8

100874174

+WAPALchr10

88260500

-
intron-intronENST00000521932ENST00000484070VPS13Bchr8

100874174

+WAPALchr10

88260500

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358544VPS13Bchr8100874174+ENST00000298767WAPALchr1088260500-1676211401111144744787
ENST00000357162VPS13Bchr8100874174+ENST00000298767WAPALchr1088260500-1668711326111143994762

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358544ENST00000298767VPS13Bchr8100874174+WAPALchr1088260500-0.0001015950.99989843
ENST00000357162ENST00000298767VPS13Bchr8100874174+WAPALchr1088260500-0.0001052830.99989474

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Fusion Genomic Features for VPS13B-WAPAL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VPS13B-WAPAL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:100874174/chr10:88260500)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWAPALchr8:100874174chr10:88260500ENST00000298767119260_2861661191.0Coiled coilOntology_term=ECO:0000255
TgeneWAPALchr8:100874174chr10:88260500ENST00000298767119749_7821661191.0Coiled coilOntology_term=ECO:0000255
TgeneWAPALchr8:100874174chr10:88260500ENST00000298767119626_11691661191.0DomainWAPL

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for VPS13B-WAPAL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98300_98300_1_VPS13B-WAPAL_VPS13B_chr8_100874174_ENST00000357162_WAPAL_chr10_88260500_ENST00000298767_length(transcript)=16687nt_BP=11326nt
GGCGCGGTACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTCTTCCGAC
TTCGACTCCTTACCTTAAAAGATGCTGGAGTCATATGTAACTCCAATTTTAATGAGCTATGTGAATCGCTACATCAAGAACTTAAAGCCG
TCGGATCTACAGCTTTCACTATGGGGTGGAGACGTGGTACTCAGCAAGCTCGAGTTAAAGTTGGATGTGCTGGAACAGGAACTGAAATTA
CCATTCACTTTTTTAAGTGGACATATTCATGAATTGAGGATTCATGTACCATGGACAAAACTGGGTTCAGAACCAGTGGTAATTACCATC
AATACTATGGAATGCATTTTGAAACTTAAGGATGGGATACAGGATGACCATGAAAGCTGTGGTTCTAATTCTACCAACCGTAGTACTGCT
GAGAGCACAAAATCATCAATCAAACCGCGGAGAATGCAGCAGGCTGCTCCTACAGATCCTGACTTACCACCAGGTTATGTGCAGAGTCTG
ATTAGACGAGTTGTAAATAATGTAAACATTGTGATAAATAATCTCATACTAAAATATGTTGAAGATGATATCGTCCTTTCCGTCAATATC
ACTTCTGCAGAATGTTATACAGTAGGTGAATTATGGGATCGTGCATTCATGGATATTTCTGCAACTGATTTGGTGCTGAGAAAGGTTATC
AATTTTTCTGACTGTACAGTTTGTCTTGATAAACGGAATGCCAGTGGTAAAATAGAATTTTACCAGGATCCTTTATTATACAAATGTTCC
TTCAGAACTCGTCTTCATTTTACATATGAAAACCTAAATTCCAAGATGCCATCTGTTATTAAAATTCATACTTTAGTGGAAAGTTTGAAA
CTTTCTATCACAGATCAACAACTGCCTATGTTTATTCGTATAATGCAACTTGGAATTGCTCTTTACTATGGAGAAATAGGCAATTTTAAA
GAAGGCGAAATAGAGGACCTTACTTGTCATAATAAAGATATGCTAGGAAACATTACAGGTTCTGAAGATGAAACAAGAATAGATATGCAA
TATCCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAGCAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTG
CCTGCAATTGTGAGTTATGACGATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCACAGACTTTG
AAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACTTTCAAACTCACAGAAATGCAAGTTGAGAGTAGTTATTAC
AGTCCACAGAAAGTAAAATCTAAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAGGCCCTTATGATGGGAGAACCTTTCTTT
GATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAAAGGAATTATGGGTGTTAAAGATTTTGAAGAGAATATGAATAGAAGT
GAAACTGAAGCCTGTTTCTTCATTTGTGGTGACAATTTGAGTACGAAAGGTTTCACATACCTTACAAATTCATTGTTTGATTACCGAAGC
CCAGAAAATAATGGTACTCGCGCAGAATTTATCTTGGATTCAACTCATCATAAGGAGACATACACTGAGATAGCTGGAATGCAACGGTTT
GGGGCTTTTTATATGGATTACCTGTATACAATGGAGAACACTAGTGGCAAAGGTTCCACAAATCAACAAGACTTTTCTTCAGGGAAAAGT
GAAGATTTGGGAACAGTTCAGGAGAAGTCCACCAAAAGCCTTGTTATAGGTCCTCTTGATTTTCGTTTGGATAGCAGTGCGGTGCATAGG
ATTTTGAAAATGATTGTGTGTGCCTTGGAACATGAATATGAACCATATAGCAGGCTAAAATCAGATATTAAGGATGAAAATGAAACAATA
CTGAATCCTGAAGAGGTGGCTCTTCTGGAGGAATATATTCCTACTCGACATACAAGTGTTACTCTCCTCAAATGTACCTGCACAATTTCC
ATGGCTGAATTCAACTTGCTGGACCATTTACTACCTGTCATTATGGGAGAAAAGAACTCAAGTAACTTCATGAATACTACAAACTTCCAG
TCTCTTCGGCCTTTGCCATCCATTCGAATATTGGTGGATAAAATTAATCTGGAACATTCAGTGCCAATGTATGCTGAACAGTTGGTGCAT
GTGGTCAGCAGCCTTACTCAACCTTCTGATAACCTGCTTCATTATTGTTATGTACACTGCTATCTTAAGATATTTGGTTTCCAGGCAGGA
CTGACGTCTTTGGATTGCAGTGGATCTTACTGCTTACCTGTACCAGTTATTCCCTCTTTCAGCACTGCTCTTTATGGGAAACTTCTGAAA
CTCCCCACATGCTGGACCAAAAGATCTCAGATTGCTATAACTGAAGGTATATTTGAACTTCCAAATCTCACAATTCAAGCTACAAGAGCA
CAGACACTTCTCTTGCAAGCAATATATCAAAGTTGGTCTCATCTTGGAAATGTCAGCTCTTCCGCAGTGATTGAAGCTTTGATAAATGAA
ATCTTCCTAAGTATAGGTGTGAAATCTAAGAATCCCCTGCCAACTCTTGAGGGCTCAATCCAGAATGTTGAATTGAAGTACTGCAGCACA
TCATTGGTCAAATGTGCCTCTGGGACCATGGGATCAATAAAAATTTGTGCCAAAGCCCCAGTTGATAGTGGAAAAGAGAAGTTGATTCCC
TTGCTTCAGGGTCCTTCTGACACTAAAGACCTTCATAGCACCAAGTGGCTCAATGAGAGTAGAAAGCCAGAGTCTCTCTTAGCTCCAGAT
TTGATGGCCTTCACAATCCAAGTTCCACAATATATTGACTACTGCCACAATTCCGGTGCTGTACTTCTTTGCAGTATACAAGGACTAGCA
GTTAATATTGACCCAATCTTATATACGTGGCTCATCTATCAGCCTCAGAAACGAACAAGTAGACATATGCAACAGCAGCCTGTGGTAGCT
GTTCCTCTTGTTATGCCAGTTTGTAGAAGGAAAGAGGATGAGGTGTCTATTGGAAGTGCCCCCTTGGCAAAGCAGCAATCATATCAGGCC
TCTGAATATGCCAGCAGCCCTGTAAAAACAAAAACGGTAACAGAATCCCGCCCATTGTCAGTTCCTGTTAAAGCCATGTTGAATATATCT
GAAAGCTGTAGAAGTCCTGAAGAAAGAATGAAGGAATTTATTGGAATTGTTTGGAATGCAGTGAAGCATCTCACACTACAGCTTGAAGTA
CAATCTTGTTGTGTGTTTATTCCAAATGATAGCCTGCCTTCCCCAAGTACAATTGTATCTGGTGACATTCCTGGAACAGTAAGAAGTTGG
TACCATGGACAAACCAGCATGCCGGGAACACTTGTCCTCTGTTTGCCTCAAATAAAGATTATTAGTGCTGGGCACAAGTATATGGAACCT
CTGCAGGAGATTCCATTTGTTATCCCACGACCCATCCTTGAAGAAGGTGATGCTTTTCCTTGGACGATCAGCTTGCATAATTTCAGCATA
TATACCCTTCTTGGAAAACAAGTGACACTTTGCCTAGTGGAACCTATGGGTTGCACCTCCACTCTAGCTGTCACGTCTCAAAAACTGCTT
GCTACGGGACCTGATACACGACATTCATTTGTTGTCTGTCTCCATGTTGACCTAGAGTCACTAGAGATAAAATGCTCTAATCCCCAGGTC
CAGCTCTTCTATGAACTAACTGATATCATGAATAAGGTCTGGAACAAGATTCAGAAGAGAGGCAATCTCAACCTATCTCCAACCTCTCCA
GAGACCATGGCAGGGCCTGTTCCTACTTCTCCAGTTAGAAGCAGTATAGGCACAGCTCCTCCAGATACCAGCACATGCAGCCCATCTGCT
GACATTGGGACTACTACTGAGGGAGATTCTATACAAGCAGGTGAGGAATCACCATTCTCAGATTCTGTGACCTTGGAACAAACTACAAGT
AATATTGGAGGAACCAGTGGACGTGTTAGTTTATGGATGCAGTGGGTGCTTCCCAAAATTACTATAAAGCTCTTTGCTCCAGATCCTGAA
AATAAAGGCACAGAGGTTTGTATGGTCAGTGAACTAGAAGATCTCAGTGCTTCCATAGATGTCCAGGATGTATATACCAAAGTGAAATGT
AAAATAGAGAGTTTCAATATTGATCACTATAGAAGCAGGCCAGGGGAAGGTTGGCAGTCAGGACATTTTGAAGGAGTATTTCTACAATGC
AAAGAAAAATCTGTGACAACTACAAAACTTCTAGATGGCACTCATCAGCAGCATGGATTCCTCTCTCTGACATACACAAAAGCTGTAACA
AAAAATGTCCGCCACAAGTTAACATCAAGAAATGAGCGAAGAAGTTTTCATAAGTTATCTGAAGGCCTAATGGATGGTTCTCCTCATTTT
CTTCATGAAATTCTTCTTTCAGCACAAGCTTTTGATATTGTTCTTTATTTTCCTTTACTTAATGCCATTGCAAGTATATTTCAAGCAAAA
CTACCAAAGACCCAAAAAGAGAAAAGAAAATCTCCTGGTCAGCCCATGAGGACCCATACACTGACATCCCGCAATTTACCTTTGATTTAT
GTCAACACAAGTGTAATCAGAATTTTTATTCCAAAAACAGAAGAAATGCAGCCAACTGTTGAAGCTAATCAGGCAGCAAAAGAAGACACT
GTGGTTTTGAAGATTGGCTCTGTTGCCATGGCTCCCCAGGCTGACAATCCCCTTGGCAGATCTGTCCTTAGGAAAGATATTTACCAGAGA
GCCTTGAACTTAGGAATTCTTCGAGATCCTGGATCAGAAATCGAAGACAGACAATACCAAATAGATCTGCAGTCCATCAATATTGGTACT
GCACAGTGGCATCAACTAAAACCAGAGAAGGAAAGTGTCTCAGGAGGGGTGGTAACAGAGACTGAAAGGAATTCTCAAAATCCAGCCCTT
GAGTGGAATATGGCCAGCAGCATACGGCGGCATCAAGAAAGGAGAGCAATTTTGACCCCCGTTTTGACAGATTTTTCTGTCCGAATAACT
GGAGCACCTGCTGTCATTTTCACCAAAGTAGTTTCTCCAGAAAATTTGCATACTGAGGAGATTTTAGTGTGTGGCCATTCCTTAGAAGTG
AATATAACCACAAACCTGGACTTCTTCCTAAGTGTGGCTCAAGTTCAACTCTTACATCAGTTAATAGTAGCAAATATGACTGGACTGGAA
CCATCAAACAAGGCTGCAGAGATCTCTAAACAAGAACAGAAAAAAGTGGATATATTTGATGGAGGCATGGCTGAAACCTCATCTCGCTAC
AGTGGTGCTCAGGATAGTGGAATTGGCAGTGACAGTGTTAAAATCAGAATAGTGCAAATAGAGCAGCACAGTGGTGCCAGTCAGCATCGC
ATTGCCCGTCCCTCACGCCAGTCATCAATTGTAAAAAATCTAAATTTTATTCCCTTTGACATATTTATTACTGCAAGTAGAATCTCACTA
ATGACCTATTCCTGTATGGCCTTATCCAAATCGAAATCACAAGAACAGAAGAATAATGAAAAAACAGACAAGAGTTCATTAAATCTCCCA
GAAGTTGATTCAGATGTTGCTAAGCCCAACCAGGCATGTATTTCCACGGTGACAGCAGAAGATCTCTTAAGGAGCAGCATTTCTTTTCCT
TCAGGGAAAAAAATAGGGGTCCTCTCTCTTGAAAGTCTTCATGCATCCACAAGGTCATCTGCTAGACAAGCACTTGGTATAACTATTGTT
CGGCAGCCTGGTCGAAGAGGAACTGGTGACTTACAGCTAGAGCCTTTTCTGTACTTTATTGTGTCCCAGCCTTCCTTGCTTCTGAGTTGT
CACCACAGAAAGCAGCGAGTGGAAGTATCCATTTTTGATGCTGTGCTTAAAGGGGTGGCCTCTGATTACAAATGTATAGATCCTGGGAAG
ACTCTGCCTGAAGCCCTTGATTATTGCACTGTTTGGCTACAGACAGTGCCTGGAGAAATAGACAGCAAAAGTGGTATTCCACCTTCCTTT
ATAACACTACAGATTAAAGACTTTCTGAATGGACCAGCGGATGTCAATTTGGATATATCAAAGCCTTTGAAAGCAAACCTGAGTTTCACC
AAACTGGATCAGATAAACCTTTTTTTAAAGAAGATAAAAAATGCACACAGTTTGGCACATAGTGAAGAGACTTCAGCCATGTCCAACACC
ATGGTGAATAAGGATGATCTTCCAGTCTCCAAATATTACCGTGGAAAGTTGTCTAAACCCAAAATTCATGGTGATGGAGTGCAAAAGATT
TCAGCTCAAGAAAACATGTGGAGAGCTGTTTCCTGCTTTCAAAAAATTTCTGTTCAAACTACTCAGATTGTGATCTCCATGGAAACTGTA
CCCCATACCAGCAAACCATGCCTGTTAGCATCTCTCTCAAACCTCAATGGAAGCCTTAGTGTCAAGGCAACACAAAAAGTACCTGGCATA
ATTCTTGGGTCATCATTTCTACTCAGTATAAACGATTTTCTCCTTAAAACAAGTCTCAAAGAAAGAAGCCGCATTCTGATAGGACCATGT
TGTGCTACTGCCAATCTGGAAGCTAAGTGGTGTAAACACAGCGGGAATCCAGGCCCAGAACAATCCATACCAAAAATATCCATTGACTTA
AGAGGAGGTCTACTACAGGTCTTCTGGGGTCAAGAACATTTGAATTGTTTAGTTCTTCTACATGAATTACTCAATGGATACCTTAATGAG
GAGGGAAATTTTGAAGTACAAGTTTCTGAACCAGTGCCTCAAATGTCATCTCCTGTGGAAAAGAATCAGACATTTAAAAGTGAACAAAGT
TCAGATGACCTACGGACAGGTCTATTTCAGTATGTACAGGATGCTGAATCTTTGAAATTGCCTGGGGTCTATGAAGTCTTATTTTATAAT
GAAACTGAAGATTGCCCAGGGATGATGTTATGGAGATATCCAGAACCTAGAGTACTCACCCTTGTACGAATAACTCCTGTACCTTTTAAC
ACCACAGAGGATCCAGATATTAGCACAGCAGACCTTGGTGATGTGCTACAGGTTCCTTGTAGCTTGGAATACTGGGATGAACTCCAGAAG
GTTTTTGTTGCATTTAGAGAATTTAATCTGTCTGAAAGCAAAGTTTGTGAACTGCAGTTGCCGGATATCAATCTCGTGAATGACCAGAAG
AAATTAGTATCTTCAGATCTTTGGAGAATTGTCTTGAACAGCAGTCAAAATGGAGCTGATGACCAAAGCTCTGCAAGTGAGTCTGGTTCT
CAAAGCACTTGTGATCCACTTGTGACTCCAACAGCCCTGGCTGCCTGTACCAGAGTTGACTCCTGCTTTACCCCATGGTTTGTCCCATCC
CTTTGCGTTTCTTTCCAGTTTGCTCACCTGGAATTCCATCTTTGTCATCACCTTGACCAACTAGGCACAGCTGCACCACAGTACCTACAG
CCATTTGTTTCCGACAGAAATATGCCATCTGAACTAGAATACATGATTGTTTCCTTCAGAGAACCACACATGTATCTTCGACAGTGGAAT
AATGGTTCTGTCTGTCAGGAGATCCAGTTCTTAGCTCAAGCAGACTGTAAACTTCTAGAGTGCAGAAATGTCACTATGCAAAGTGTGGTG
AAACCCTTCAGCATCTTCGGGCAGATGGCAGTTTCCAGCGATGTAGTGGAAAAGCTGCTTGACTGCACCGTGATAGTTGATTCTGTATTT
GTAAACCTTGGACAGCATGTAGTCCATTCACTAAACACTGCAATACAAGCTTGGCAACAGAACAAATGCCCTGAGGTAGAGGAGTTGGTC
TTCAGCCATTTTGTGATCTGTAATGACACACAGGAGACACTGCGGTTTGGCCAGGTGGATACTGATGAAAATATTCTGCTGGCGAGTCTC
CACAGTCACCAGTACAGCTGGCGCTCTCACAAATCCCCACAGCTGTTACACATCTGTATTGAAGGTTGGGGCAACTGGCGTTGGTCAGAG
CCTTTCAGTGTGGACCATGCCGGGACTTTTATTAGAACAATTCAGTACAGGGGTCGAACTGCTTCTCTCATCATCAAGGTTCAGCAACTC
AATGGAGTACAAAAACAGATTATCATCTGTGGAAGACAGATCATCTGTAGTTACTTGTCTCAAAGCATAGAACTAAAAGTCGTTCAGCAT
TACATTGGTCAAGATGGACAAGCTGTAGTTCGGGAACATTTTGACTGCCTCACAGCCAAACAGAAATTGCCTTCGTACATACTAGAAAAC
AATGAACTGACGGAGCTGTGTGTGAAGGCCAAAGGAGATGAAGACTGGTCAAGAGATGTGTGCCTGGAATCCAAAGCCCCTGAGTACAGC
ATTGTCATTCAGGTGCCATCTTCAAACAGTTCCATTATTTATGTCTGGTGCACAGTTTTGACTTTAGAACCCAACTCTCAAGTGCAACAA
CGAATGATTGTGTTCAGCCCTCTTTTTATCATGAGGAGTCATCTTCCAGACCCCATTATCATACATTTGGAGAAAAGGAGTCTGGGATTG
AGTGAAACACAAATTATTCCAGGAAAAGGGCAGGAAAAACCACTGCAAAACATAGAACCTGACCTTGTACATCACCTGACATTCCAAGCA
AGAGAAGAATATGATCCTTCAGATTGTGCAGTTCCCATCTCAACATCCCTCATTAAGCAAATAGCCACTAAGGTACACCCTGGAGGCACA
GTTAATCAGATCCTTGACGAATTCTATGGGCCAGAAAAGTCGCTTCAACCCATATGGCCCTATAATAAGAAGGATTCTGACAGGAATGAA
CAGCTAAGTCAGTGGGATAGCCCAATGCGAGTGAAGCTGTCAATCTGGAAGCCATATGTTAGAACTTTGTTGATAGAACTTCTGCCCTGG
GCCCTGCTTATCAATGAATCCAAATGGGACCTCTGGCTATTTGAAGGAGAGAAAATTGTTCTACAGGTTCCTGCTGGCAAAATTATTATT
CCTCCTAATTTTCAGGAAGCTTTTCAAATTGGAATATACTGGGCAAATACAAACACTGTGCACAAGTCAGTAGCAATTAAACTGGTCCAT
AACCTGACATCTCCAAAGTGGAAAGATGGAGGTAATGGTGAAGTTGTGACACTGGATGAAGAAGCGTTTGTTGATACTGAAATAAGACTT
GGTGCTTTTCCAGGACATCAGAAGTTATGTCAGTTCTGCATTTCCTCCATGGTACAGCAAGGTATACAAATTATTCAGATTGAAGACAAG
ACTACAATAATCAATAATACACCATATCAAATATTTTATAAACCACAGCTATCTGTCTGCAATCCCCATTCTGGAAAGGAGTATTTTCGT
GTTCCAGACAGTGCTACTTTTAGCATTTGCCCAGGTGGAGAGCAGCCTGCTATGAAATCCAGCTCCCTTCCTTGCTGGGACTTGATGCCT
GACATCAGTCAGTCAGTACTGGATGCATCCCTGCTTCAGAAACAGATCATGCTGGGCTTTTCTCCTGCCCCAGGTGCTGACAGCTCACAG
TGCTGGAGCCTGCCAGCTATAGTTAGACCAGAGTTTCCCAGACAGAGTGTGGCAGTACCCCTCGGGAATTTCCGGGAAAATGGATTCTGT
ACCAGGGCTATAGTGCTGACATATCAAGAACACCTCGGAGTGACTTATTTAACCCTCTCAGAAGACCCTAGTCCTCGAGTAATTATCCAC
AATAGATGTCCAGTAAAAATGCTTATAAAGGAAAACATTAAAGATATTCCAAAGTTTGAGGTTTATTGCAAAAAAATTCCCTCCGAGTGC
TCAATTCATCATGAGCTGTATCATCAGATTTCCAGTTATCCGGACTGCAAGACCAAAGACTTACTTCCAAGCCTACTTTTGAGAGTTGAA
CCTCTAGATGAAGTAACAACTGAGTGGAGTGATGCCATTGACATCAACAGTCAGGGAACACAGGTTGTGTTCCTGACTGGCTTTGGCTAT
GTGTATGTGGATGTTGTACATCAGTGTGGCACAGTCTTCATCACTGTGGCCCCAGAAGGAAAAGCAGGACCTATTTTAACCAATACCAAC
AGAGCGCCAGAGAAGATTGTTACATTTAAAATGTTCATCACTCAGTTAAGCCTGGCAGTGTTTGATGACCTCACCCACCACAAAGCATCA
GCTGAGCTTCTGAGACTCACACTGGACAACATTTTTCTCTGTGTGGCCCCGGGAGCTGGTCCCCTCCCTGGGGAAGAGCCTGTGGCTGCG
TTGTTTGAACTTTACTGTGTGGAGATCTGCTGTGGGGACCTGCAGCTAGACAACCAGCTTTATAACAAGTCCAATTTCCACTTTGCTGTC
TTAGTCTGCCAGGGAGAAAAAGCAGAACCCATTCAGTGTTCCAAAATGCAGAGTCTCCTCATATCCAACAAAGAGTTGGAAGAATACAAG
GAAAAATGTTTTATCAAACTTTGCATCACCTTAAATGAAGGCAAGAGCATCCTCTGTGATATTAATGAGTTCAGCTTTGAATTAAAACCT
GCTCGGTTATACGTGGAAGACACATTTGTATACTACATCAAGACTTTGTTTGACACCTACCTTCCTAACAGCAGGTTGGCTGGTCACTCC
ACACACCTCTCCGGGGGTAAACAGGTGTTGCCCATGCAGGTCACACAGCACGCCAGGGCCTTGGTGAATCCTGTGAAGTTACGGAAACTG
GTGATCCAGCCAGTAAATTTGCTCGTCAGCATCCACGCTTCCCTCAAGCTGTACATAGCCTCAGACCACACTCCTCTCTCCTTCTCGGTG
TTTGAAAGAGGACCCATCTTCACCACTGCGAGGCAGCTTGTGCACGCCCTGGCAATGCACTATGCCGCTGGGGCCCTTTTTAGAGCAGGC
TGGGTAGTTGGGTCTCTGGATATTCTTGGCAGCCCTGCAAGCCTGGTGAGAAGCATCGGGAACGGGGTCGCCGACTTCTTCAGGCTTCCG
TATGAGGGGCTGACCCGGGGCCCTGGAGCCTTCGTGAGTGGCGTCTCCAGAGGGACCACATCGTTTGTAAAGCACATCTCCAAAGGTACC
CTCACATCCATCACCAACCTCGCCACAAGCCTGGCCCGGAACATGGACCGGCTCTCACTGGATGAGGAGCACTACAACCGGCAGGAGGAG
TGGCGGCGGCAGCTCCCCGAGAGCCTGGGCGAGGGGCTTCGACAGGGCCTGTCCCGGCTGGGCATCAGCCTGCTTGATAAAGTGGAGAAT
TTTCATGAAGAACATGAAAAGAATAGTCACCATATTCACAAAAATGCTGATGACAGTACTAAGAAACCCAATGCAGAAACTACAGTGGCT
TCTGAAATCAAGGAAACAAATGATACTTGGAACTCCCAGTTTGGGAAAAGGCCAGAATCACCATCAGAAATATCTCCAATCAAGGGATCT
GTTAGAACTGGTTTGTTTGAATGGGATAATGATTTTGAAGATATCAGATCAGAAGACTGTATTTTAAGTTTGGATAGTGATCCCCTTTTG
GAGATGAAGGATGACGATTTTAAAAATCGATTGGAAAATCTGAATGAAGCCATTGAGGAAGATATTGTACAAAGTGTTCTTAGGCCAACC
AACTGTAGGACGTACTGTAGGGCCAATAAAACGAAATCCTCCCAAGGAGCATCAAATTTTGATAAGCTGATGGACGGCACCAGTCAGGCC
TTAGCCAAAGCAAACAGTGAATCGAGTAAAGATGGCCTGAATCAGGCAAAGAAAGGGGGTGTAAGTTGTGGGACCAGTTTTAGAGGGACA
GTTGGACGGACTAGAGATTACACTGTTTTACATCCATCTTGCTTGTCAGTTTGTAATGTTACCATACAGGATACTATGGAACGCAGCATG
GATGAGTTCACTGCATCCACTCCTGCAGATTTGGGAGAAGCTGGTCGTCTCAGAAAAAAGGCAGATATTGCAACTTCTAAGACTACTACT
AGATTTCGACCTAGTAATACTAAATCCAAAAAGGATGTTAAACTTGAATTTTTTGGTTTTGAAGATCATGAGACAGGAGGTGATGAAGGA
GGTTCTGGAAGTTCTAATTACAAAATTAAGTATTTTGGCTTTGATGATCTCAGTGAAAGCGAAGATGATGAAGATGATGACTGTCAAGTA
GAAAGAAAGACAAGCAAAAAAAGAACTAAAACAGCTCCATCACCCTCCTTGCAGCCTCCCCCAGAAAGCAATGATAATTCCCAGGACAGT
CAGTCTGGTACTAACAATGCAGAAAACTTGGATTTTACAGAGGACTTGCCTGGTGTGCCTGAAAGTGTGAAGAAGCCCATAAATAAACAA
GGAGATAAATCAAAGGAAAATACCAGAAAGATTTTTAGTGGCCCCAAACGGTCACCCACAAAAGCTGTATATAATGCCAGACATTGGAAT
CATCCAGATTCAGAAGAACTGCCTGGGCCACCAGTAGTAAAACCTCAGAGTGTCACAGTGAGGCTGTCTTCAAAGGAACCAAATCAAAAA
GATGATGGAGTTTTTAAGGCTCCTGCACCACCATCCAAAGTGATAAAAACTGTGACAATACCTACTCAGCCCTACCAAGATATAGTTACT
GCACTGAAATGCAGACGAGAAGACAAAGAATTATATACTGTTGTTCAGCACGTGAAGCACTTCAACGATGTTGTAGAATTTGGTGAAAAT
CAAGAGTTCACTGATGACATTGAGTACTTGTTAAGTGGCTTAAAGAGCACTCAGCCTCTAAACACACGTTGCCTTAGTGTTATTAGCTTG
GCTACTAAATGTGCCATGCCCAGTTTTCGAATGCACCTGAGAGCACATGGGATGGTAGCAATGGTCTTTAAAACCTTGGATGATTCCCAG
CACCATCAGAATCTGTCCCTCTGTACAGCTGCCCTCATGTATATACTGAGTAGAGATCGTTTGAACATGGATCTTGATAGAGCTAGCTTA
GATCTAATGATTCGACTTTTGGAACTGGAACAAGATGCTTCATCAGCCAAGCTACTGAATGAAAAAGACATGAACAAAATTAAAGAAAAA
ATCCGAAGGCTCTGTGAAACTGTACACAACAAGCATCTTGATCTAGAAAATATAACGACTGGGCATTTAGCTATGGAGACATTATTATCC
CTTACTTCTAAACGAGCAGGAGACTGGTTTAAAGAAGAACTCCGGCTTTTGGGTGGTCTGGATCATATTGTAGATAAAGTAAAAGAATGT
GTGGATCATTTAAGTAGAGATGAGGATGAAGAGAAACTGGTAGCCTCACTATGGGGAGCAGAGAGATGTTTACGAGTTTTAGAAAGTGTA
ACTGTGCATAATCCCGAAAATCAAAGCTACTTGATAGCATATAAAGATTCCCAACTTATTGTTTCATCAGCTAAAGCATTACAGCATTGT
GAAGAACTGATTCAGCAGTACAACCGTGCTGAGGACAGCATATGCTTAGCTGACAGTAAGCCTCTGCCTCACCAGAATGTAACTAACCAT
GTAGGCAAAGCAGTGGAGGACTGCATGAGGGCCATCATCGGGGTGTTGCTTAATTTAACTAATGATAATGAGTGGGGCAGCACCAAAACA
GGAGAGCAGGACGGTCTCATAGGCACAGCGCTGAACTGTGTGCTTCAGGTTCCAAAGTACCTACCTCAGGAGCAGAGATTTGATATTCGA
GTGCTGGGCTTAGGTCTGCTGATAAATCTAGTGGAGTATAGTGCTCGGAATCGGCACTGTCTTGTCAACATGGAAACATCGTGCTCTTTT
GATTCTTCCATCTGTAGTGGAGAAGGGGATGATAGTTTAAGGATAGGTGGACAAGTTCATGCTGTCCAGGCTTTAGTGCAGCTATTCCTT
GAGCGAGAGCGGGCAGCCCAGCTAGCAGAAAGTAAAACAGATGAGTTGATCAAAGATGCTCCCACCACTCAGCATGATAAGAGTGGAGAG
TGGCAAGAAACAAGTGGAGAAATACAGTGGGTGTCAACTGAAAAGACTGATGGTACAGAAGAGAAACATAAGAAGGAGGAGGAGGATGAA
GAACTTGACCTCAATAAAGCCCTTCAGCATGCCGGCAAACACATGGAGGATTGCATTGTGGCCTCCTACACAGCACTACTTCTTGGGTGT
CTCTGCCAGGAAAGTCCAATCAATGTAACCACTGTGCGGGAATATCTGCCAGAAGGAGACTTTTCAATAATGACAGAGATGCTCAAAAAA
TTTTTGAGTTTTATGAATCTCACTTGTGCTGTTGGAACAACTGGCCAGAAATCTATCTCTAGAGTGATTGAATATTTGGAACATTGCTAG
CTGCTTTACCTTTGCTTCAGGTGCTCGGTAATGCTGGAGCTATCCTTAGACAAAGAAAAGTCAAGTCATGAAAGAAGTCCTTGAAGATAT
ACCAAGAACATTCATCAGTATCATTCGTGTTTGGATTTTTAAGGCCACCTGATTTCTTCGTCATGCATTCGGCATTTGCTAAATGACAGT
TACTACATCAATCTGCAACTATCAAAAATGAGGGGAAAAGGTTCAGGCTGTTAACAATTCCATGCAGTATTTAAATACATTTACTTTGGC
AGAGTTTATACCCTCCCCTTGTTTTCTTGCTTTATTCTGGGCAAGTTTGAAGGGGAAAATTTGTGCTGCTGTTAGTGCAACTGCTGTGTA
TGTTGAGCCACTGTTGTCATGCCAGCCAGGTGCAAAGGCAGCTTAGCTACTGAGGTAGCGAATGTTCTGAGGACATTCTAGACAACAGCT
TAGTTCCTTTTTCAGGCTCATTTGCTTTTGCTTTTTTGTTGAATGATTCCAATCGTAAATAAAGCTTTTAATAATTTTGTGAATTTTTTG
GTTGTTGTTCCCTGAACTACTGTCTATATTTAAAATTAGATGGAATCCAAAGATACACGGGATTAATAGTATATTTTTTTATTCTTGATT
AGGTTTGGGTTATTGAACTATTTTTTACTTTTGAGACCACAACCATATTCAATATCATACCATAATGTGTCATAGCTATAGGCACAAGAA
AAACAACAGTTTGAGAGAATATTATATAAGATGATGTGCCCTGTTAAAAGGAGGAGGCAAAATAGTCAAACCCAGGGTAGTTTACACTTA
ATGCTAGGGAGGCTCTTAAAACATTATTAGATTTTGAGGAAAGACTCTCTAGATATATTTTCTAATGTTCAGTACAATAAATATAAGGAA
GCTAAAACACCAATGTGGAATTCCTGTTTCCAGATAACATGTATATTCTTCTATAGAGTGACAGGATCAATTGCATAAGCGCAAAGCCTT
AAATTGCTGGTTTAGAGAAGACCCTTTTTTCATTCAGATTCTTTGTTCGTAGAGCAGTTATTTGAAAAACAGTTATGGAACACAAAACAT
TTTATAGATTTAATATCATAACATTGCAAATTTTTCTTGTATTATTCACACCACTGGTTATACTTTTTTTTTTCCTTTTTTATTGATTGG
GCCTGAATACAGGCTTTCTAGAGATCTTTTTCATTAATACTTTTAAATACCTTTCAGGTAGTTACATCATGTTTCTTCATTGGATTTGTA
AAACTTGAAGCCATAAAAATATTAGTTTGGTGTGTATTGGGGAAAATAGCTAAAAGTCTAATTTTTACCCATTTAGACTTTGTTATTTCC
TTGTATAAAGTGACAAATCGGGGCTCTTGTATCAGTGCCAGCTGTAATGTTTTTAAATGCAGTGGCTGCCTTCTATTGTCTTCCTATTTT
TGATAATGCAGATTGTTGGGAAATCTGTAAGGAAGTAACTGATTCCAGGCAAATTGTTTTCTTCCTTCTACCCACCCCAACCCCTACCCA
TCACCTTTTAAGAACATAGTACGCCAGTGTAACGTGGGAACCATTGAGATTGTATTTGCCCTGAGTATTAAAGCTAGCTTAGCAAAATAC
TTTTAAAAACATATTGGTAAATGATACCCGTAAAATTAAATTAGTTATATTTTATTTTAAAATGCAAAATACATTGATATTTATTAATCA
TTGGATTTAGGGAAAGGGACAGATTTTTGGTGAACCTGACTTGTGGCAGATGGTAAGGAATATTATAAAACATTTGGATGAGAACAATCA
GGGCGAACTGCATTTTTCTGTTACACTGGTAATCATTTGAAAATTGATTTACCTCAGTGTTTAACAGTTTTTTGTTTTGTTTTGTTTTTT
AAATAATAACTAATTGTCGAGCACTGATAGAGATGCAGATTTTGGTGGGGGGAGGTGGTGGGGGAGATAATCACTTCACCAACTGCAGTG
CATTTGTGTGTTTTTAACCCTCAGAGAACTCTGCATTTTAGGGTACTTGAGGCTGACTTAACTAAAAGTTTTAAAGTAACCTTTTTTCCA
TTGTAAATATTTCTGTAAATACTACCAATTGGAAATTAGAACAGTAGAGTACTTTTCTGAATCCAATCCTATTTTTATTTTATACAGTAT
TTCTCAGCTGTGATCTTTGGAGCAAAAGCCAACGGCAGGAAAAAATAGTTTGTACCAGTTTCATGAAGTATGTCTTTGGGTTTTTGTAAA

>98300_98300_1_VPS13B-WAPAL_VPS13B_chr8_100874174_ENST00000357162_WAPAL_chr10_88260500_ENST00000298767_length(amino acids)=4762AA_BP=3724
MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELRIHVPWTKLGSEPVVITINTMECIL
KLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYT
VGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQ
LPMFIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQDEEQPQGWVSWAWSFVPAIVSYD
DGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRFGAFYMDY
LYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPEEVA
LLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQ
PSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLLLQA
IYQSWSHLGNVSSSAVIEALINEIFLSIGVKSKNPLPTLEGSIQNVELKYCSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSD
TKDLHSTKWLNESRKPESLLAPDLMAFTIQVPQYIDYCHNSGAVLLCSIQGLAVNIDPILYTWLIYQPQKRTSRHMQQQPVVAVPLVMPV
CRRKEDEVSIGSAPLAKQQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNISESCRSPEERMKEFIGIVWNAVKHLTLQLEVQSCCVFI
PNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISAGHKYMEPLQEIPFVIPRPILEEGDAFPWTISLHNFSIYTLLGKQ
VTLCLVEPMGCTSTLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDIMNKVWNKIQKRGNLNLSPTSPETMAGPV
PTSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEESPFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGTEVC
MVSELEDLSASIDVQDVYTKVKCKIESFNIDHYRSRPGEGWQSGHFEGVFLQCKEKSVTTTKLLDGTHQQHGFLSLTYTKAVTKNVRHKL
TSRNERRSFHKLSEGLMDGSPHFLHEILLSAQAFDIVLYFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYVNTSVIR
IFIPKTEEMQPTVEANQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRDPGSEIEDRQYQIDLQSINIGTAQWHQLK
PEKESVSGGVVTETERNSQNPALEWNMASSIRRHQERRAILTPVLTDFSVRITGAPAVIFTKVVSPENLHTEEILVCGHSLEVNITTNLD
FFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQKKVDIFDGGMAETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSRQ
SSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKSQEQKNNEKTDKSSLNLPEVDSDVAKPNQACISTVTAEDLLRSSISFPSGKKIGV
LSLESLHASTRSSARQALGITIVRQPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCIDPGKTLPEALD
YCTVWLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFTKLDQINLFLKKIKNAHSLAHSEETSAMSNTMVNKDDL
PVSKYYRGKLSKPKIHGDGVQKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPCLLASLSNLNGSLSVKATQKVPGIILGSSFL
LSINDFLLKTSLKERSRILIGPCCATANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVFWGQEHLNCLVLLHELLNGYLNEEGNFEVQ
VSEPVPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQDAESLKLPGVYEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDI
STADLGDVLQVPCSLEYWDELQKVFVAFREFNLSESKVCELQLPDINLVNDQKKLVSSDLWRIVLNSSQNGADDQSSASESGSQSTCDPL
VTPTALAACTRVDSCFTPWFVPSLCVSFQFAHLEFHLCHHLDQLGTAAPQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQE
IQFLAQADCKLLECRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNLGQHVVHSLNTAIQAWQQNKCPEVEELVFSHFVIC
NDTQETLRFGQVDTDENILLASLHSHQYSWRSHKSPQLLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGRTASLIIKVQQLNGVQKQI
IICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTELCVKAKGDEDWSRDVCLESKAPEYSIVIQVPS
SNSSIIYVWCTVLTLEPNSQVQQRMIVFSPLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDPS
DCAVPISTSLIKQIATKVHPGGTVNQILDEFYGPEKSLQPIWPYNKKDSDRNEQLSQWDSPMRVKLSIWKPYVRTLLIELLPWALLINES
KWDLWLFEGEKIVLQVPAGKIIIPPNFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEIRLGAFPGHQ
KLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVCNPHSGKEYFRVPDSATFSICPGGEQPAMKSSSLPCWDLMPDISQSVL
DASLLQKQIMLGFSPAPGADSSQCWSLPAIVRPEFPRQSVAVPLGNFRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRVIIHNRCPVKM
LIKENIKDIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSLLLRVEPLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDVVH
QCGTVFITVAPEGKAGPILTNTNRAPEKIVTFKMFITQLSLAVFDDLTHHKASAELLRLTLDNIFLCVAPGAGPLPGEEPVAALFELYCV
EICCGDLQLDNQLYNKSNFHFAVLVCQGEKAEPIQCSKMQSLLISNKELEEYKEKCFIKLCITLNEGKSILCDINEFSFELKPARLYVED
TFVYYIKTLFDTYLPNSRLAGHSTHLSGGKQVLPMQVTQHARALVNPVKLRKLVIQPVNLLVSIHASLKLYIASDHTPLSFSVFERGPIF
TTARQLVHALAMHYAAGALFRAGWVVGSLDILGSPASLVRSIGNGVADFFRLPYEGLTRGPGAFVSGVSRGTTSFVKHISKGTLTSITNL
ATSLARNMDRLSLDEEHYNRQEEWRRQLPESLGEGLRQGLSRLGISLLDKVENFHEEHEKNSHHIHKNADDSTKKPNAETTVASEIKETN
DTWNSQFGKRPESPSEISPIKGSVRTGLFEWDNDFEDIRSEDCILSLDSDPLLEMKDDDFKNRLENLNEAIEEDIVQSVLRPTNCRTYCR
ANKTKSSQGASNFDKLMDGTSQALAKANSESSKDGLNQAKKGGVSCGTSFRGTVGRTRDYTVLHPSCLSVCNVTIQDTMERSMDEFTAST
PADLGEAGRLRKKADIATSKTTTRFRPSNTKSKKDVKLEFFGFEDHETGGDEGGSGSSNYKIKYFGFDDLSESEDDEDDDCQVERKTSKK
RTKTAPSPSLQPPPESNDNSQDSQSGTNNAENLDFTEDLPGVPESVKKPINKQGDKSKENTRKIFSGPKRSPTKAVYNARHWNHPDSEEL
PGPPVVKPQSVTVRLSSKEPNQKDDGVFKAPAPPSKVIKTVTIPTQPYQDIVTALKCRREDKELYTVVQHVKHFNDVVEFGENQEFTDDI
EYLLSGLKSTQPLNTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQNLSLCTAALMYILSRDRLNMDLDRASLDLMIRLL
ELEQDASSAKLLNEKDMNKIKEKIRRLCETVHNKHLDLENITTGHLAMETLLSLTSKRAGDWFKEELRLLGGLDHIVDKVKECVDHLSRD
EDEEKLVASLWGAERCLRVLESVTVHNPENQSYLIAYKDSQLIVSSAKALQHCEELIQQYNRAEDSICLADSKPLPHQNVTNHVGKAVED
CMRAIIGVLLNLTNDNEWGSTKTGEQDGLIGTALNCVLQVPKYLPQEQRFDIRVLGLGLLINLVEYSARNRHCLVNMETSCSFDSSICSG
EGDDSLRIGGQVHAVQALVQLFLERERAAQLAESKTDELIKDAPTTQHDKSGEWQETSGEIQWVSTEKTDGTEEKHKKEEEDEELDLNKA

--------------------------------------------------------------
>98300_98300_2_VPS13B-WAPAL_VPS13B_chr8_100874174_ENST00000358544_WAPAL_chr10_88260500_ENST00000298767_length(transcript)=16762nt_BP=11401nt
GGCGCGGTACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTCTTCCGAC
TTCGACTCCTTACCTTAAAAGATGCTGGAGTCATATGTAACTCCAATTTTAATGAGCTATGTGAATCGCTACATCAAGAACTTAAAGCCG
TCGGATCTACAGCTTTCACTATGGGGTGGAGACGTGGTACTCAGCAAGCTCGAGTTAAAGTTGGATGTGCTGGAACAGGAACTGAAATTA
CCATTCACTTTTTTAAGTGGACATATTCATGAATTGAGGATTCATGTACCATGGACAAAACTGGGTTCAGAACCAGTGGTAATTACCATC
AATACTATGGAATGCATTTTGAAACTTAAGGATGGGATACAGGATGACCATGAAAGCTGTGGTTCTAATTCTACCAACCGTAGTACTGCT
GAGAGCACAAAATCATCAATCAAACCGCGGAGAATGCAGCAGGCTGCTCCTACAGATCCTGACTTACCACCAGGTTATGTGCAGAGTCTG
ATTAGACGAGTTGTAAATAATGTAAACATTGTGATAAATAATCTCATACTAAAATATGTTGAAGATGATATCGTCCTTTCCGTCAATATC
ACTTCTGCAGAATGTTATACAGTAGGTGAATTATGGGATCGTGCATTCATGGATATTTCTGCAACTGATTTGGTGCTGAGAAAGGTTATC
AATTTTTCTGACTGTACAGTTTGTCTTGATAAACGGAATGCCAGTGGTAAAATAGAATTTTACCAGGATCCTTTATTATACAAATGTTCC
TTCAGAACTCGTCTTCATTTTACATATGAAAACCTAAATTCCAAGATGCCATCTGTTATTAAAATTCATACTTTAGTGGAAAGTTTGAAA
CTTTCTATCACAGATCAACAACTGCCTATGTTTATTCGTATAATGCAACTTGGAATTGCTCTTTACTATGGAGAAATAGGCAATTTTAAA
GAAGGCGAAATAGAGGACCTTACTTGTCATAATAAAGATATGCTAGGAAACATTACAGGTTCTGAAGATGAAACAAGAATAGATATGCAA
TATCCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAGCAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTG
CCTGCAATTGTGAGTTATGACGATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCACAGACTTTG
AAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACTTTCAAACTCACAGAAATGCAAGTTGAGAGTAGTTATTAC
AGTCCACAGAAAGTAAAATCTAAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAGGCCCTTATGATGGGAGAACCTTTCTTT
GATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAAAGGAATTATGGGTGTTAAAGATTTTGAAGAGAATATGAATAGAAGT
GAAACTGAAGCCTGTTTCTTCATTTGTGGTGACAATTTGAGTACGAAAGGTTTCACATACCTTACAAATTCATTGTTTGATTACCGAAGC
CCAGAAAATAATGGTACTCGCGCAGAATTTATCTTGGATTCAACTCATCATAAGGAGACATACACTGAGATAGCTGGAATGCAACGGTTT
GGGGCTTTTTATATGGATTACCTGTATACAATGGAGAACACTAGTGGCAAAGGTTCCACAAATCAACAAGACTTTTCTTCAGGGAAAAGT
GAAGATTTGGGAACAGTTCAGGAGAAGTCCACCAAAAGCCTTGTTATAGGTCCTCTTGATTTTCGTTTGGATAGCAGTGCGGTGCATAGG
ATTTTGAAAATGATTGTGTGTGCCTTGGAACATGAATATGAACCATATAGCAGGCTAAAATCAGATATTAAGGATGAAAATGAAACAATA
CTGAATCCTGAAGAGGTGGCTCTTCTGGAGGAATATATTCCTACTCGACATACAAGTGTTACTCTCCTCAAATGTACCTGCACAATTTCC
ATGGCTGAATTCAACTTGCTGGACCATTTACTACCTGTCATTATGGGAGAAAAGAACTCAAGTAACTTCATGAATACTACAAACTTCCAG
TCTCTTCGGCCTTTGCCATCCATTCGAATATTGGTGGATAAAATTAATCTGGAACATTCAGTGCCAATGTATGCTGAACAGTTGGTGCAT
GTGGTCAGCAGCCTTACTCAACCTTCTGATAACCTGCTTCATTATTGTTATGTACACTGCTATCTTAAGATATTTGGTTTCCAGGCAGGA
CTGACGTCTTTGGATTGCAGTGGATCTTACTGCTTACCTGTACCAGTTATTCCCTCTTTCAGCACTGCTCTTTATGGGAAACTTCTGAAA
CTCCCCACATGCTGGACCAAAAGATCTCAGATTGCTATAACTGAAGGTATATTTGAACTTCCAAATCTCACAATTCAAGCTACAAGAGCA
CAGACACTTCTCTTGCAAGCAATATATCAAAGTTGGTCTCATCTTGGAAATGTCAGCTCTTCCGCAGTGATTGAAGCTTTGATAAATGAA
ATCTTCCTAAGTATAGGTGTGAAATCTAAGAATCCCCTGCCAACTCTTGAGGGCTCAATCCAGAATGTTGAATTGAAGTACTGCAGCACA
TCATTGGTCAAATGTGCCTCTGGGACCATGGGATCAATAAAAATTTGTGCCAAAGCCCCAGTTGATAGTGGAAAAGAGAAGTTGATTCCC
TTGCTTCAGGGTCCTTCTGACACTAAAGACCTTCATAGCACCAAGTGGCTCAATGAGAGTAGAAAGCCAGAGTCTCTCTTAGCTCCAGAT
TTGATGGCCTTCACAATCCAAGTTCCACAATATATTGACTACTGCCACAATTCCGGTGCTGTACTTCTTTGCAGTATACAAGGACTAGCA
GTTAATATTGACCCAATCTTATATACGTGGCTCATCTATCAGCCTCAGAAACGAACAAGTAGACATATGCAACAGCAGCCTGTGGTAGCT
GTTCCTCTTGTTATGCCAGTTTGTAGAAGGAAAGAGGATGAGGTGTCTATTGGAAGTGCCCCCTTGGCAAAGCAGCAATCATATCAGGCC
TCTGAATATGCCAGCAGCCCTGTAAAAACAAAAACGGTAACAGAATCCCGCCCATTGTCAGTTCCTGTTAAAGCCATGTTGAATATATCT
GAAAGCTGTAGAAGTCCTGAAGAAAGAATGAAGGAATTTATTGGAATTGTTTGGAATGCAGTGAAGCATCTCACACTACAGCTTGAAGTA
CAATCTTGTTGTGTGTTTATTCCAAATGATAGCCTGCCTTCCCCAAGTACAATTGTATCTGGTGACATTCCTGGAACAGTAAGAAGTTGG
TACCATGGACAAACCAGCATGCCGGGAACACTTGTCCTCTGTTTGCCTCAAATAAAGATTATTAGTGCTGGGCACAAGTATATGGAACCT
CTGCAGGAGATTCCATTTGTTATCCCACGACCCATCCTTGAAGAAGGTGATGCTTTTCCTTGGACGATCAGCTTGCATAATTTCAGCATA
TATACCCTTCTTGGAAAACAAGTGACACTTTGCCTAGTGGAACCTATGGGTTGCACCTCCACTCTAGCTGTCACGTCTCAAAAACTGCTT
GCTACGGGACCTGATACACGACATTCATTTGTTGTCTGTCTCCATGTTGACCTAGAGTCACTAGAGATAAAATGCTCTAATCCCCAGGTC
CAGCTCTTCTATGAACTAACTGATATCATGAATAAGGTCTGGAACAAGATTCAGAAGAGAGGCAATCTCAACCTATCTCCAACCTCTCCA
GAGACCATGGCAGGGCCTGTTCCTACTTCTCCAGTTAGAAGCAGTATAGGCACAGCTCCTCCAGATACCAGCACATGCAGCCCATCTGCT
GACATTGGGACTACTACTGAGGGAGATTCTATACAAGCAGGTGAGGAATCACCATTCTCAGATTCTGTGACCTTGGAACAAACTACAAGT
AATATTGGAGGAACCAGTGGACGTGTTAGTTTATGGATGCAGTGGGTGCTTCCCAAAATTACTATAAAGCTCTTTGCTCCAGATCCTGAA
AATAAAGGCACAGAGGTTTGTATGGTCAGTGAACTAGAAGATCTCAGTGCTTCCATAGATGTCCAGGATGTATATACCAAAGTGAAATGT
AAAATAGAGAGTTTCAATATTGATCACTATAGAAGCAGCCTTGGGGAAGAGTGTTGGTCTTTGGGGCAATGTGGAGGTGTCTTCCTTTCC
TGTACTGACAAGCTGAACAGACGCACCTTGTTGGTTCGACCCATCAGCAAGCAGGACCCTTTCAGTAATTGCTCTGGCTTCTTTCCTTCT
ACAACTACAAAACTTCTAGATGGCACTCATCAGCAGCATGGATTCCTCTCTCTGACATACACAAAAGCTGTAACAAAAAATGTCCGCCAC
AAGTTAACATCAAGAAATGAGCGAAGAAGTTTTCATAAGTTATCTGAAGGCCTAATGGATGGTTCTCCTCATTTTCTTCATGAAATTCTT
CTTTCAGCACAAGCTTTTGATATTGTTCTTTATTTTCCTTTACTTAATGCCATTGCAAGTATATTTCAAGCAAAACTACCAAAGACCCAA
AAAGAGAAAAGAAAATCTCCTGGTCAGCCCATGAGGACCCATACACTGACATCCCGCAATTTACCTTTGATTTATGTCAACACAAGTGTA
ATCAGAATTTTTATTCCAAAAACAGAAGAAATGCAGCCAACTGTTGAAGCTAATCAGGCAGCAAAAGAAGACACTGTGGTTTTGAAGATT
GGCTCTGTTGCCATGGCTCCCCAGGCTGACAATCCCCTTGGCAGATCTGTCCTTAGGAAAGATATTTACCAGAGAGCCTTGAACTTAGGA
ATTCTTCGAGATCCTGGATCAGAAATCGAAGACAGACAATACCAAATAGATCTGCAGTCCATCAATATTGGTACTGCACAGTGGCATCAA
CTAAAACCAGAGAAGGAAAGTGTCTCAGGAGGGGTGGTAACAGAGACTGAAAGGAATTCTCAAAATCCAGCCCTTGAGTGGAATATGGCC
AGCAGCATACGGCGGCATCAAGAAAGGAGAGCAATTTTGACCCCCGTTTTGACAGATTTTTCTGTCCGAATAACTGGAGCACCTGCTGTC
ATTTTCACCAAAGTAGTTTCTCCAGAAAATTTGCATACTGAGGAGATTTTAGTGTGTGGCCATTCCTTAGAAGTGAATATAACCACAAAC
CTGGACTTCTTCCTAAGTGTGGCTCAAGTTCAACTCTTACATCAGTTAATAGTAGCAAATATGACTGGACTGGAACCATCAAACAAGGCT
GCAGAGATCTCTAAACAAGAACAGAAAAAAGTGGATATATTTGATGGAGGCATGGCTGAAACCTCATCTCGCTACAGTGGTGCTCAGGAT
AGTGGAATTGGCAGTGACAGTGTTAAAATCAGAATAGTGCAAATAGAGCAGCACAGTGGTGCCAGTCAGCATCGCATTGCCCGTCCCTCA
CGCCAGTCATCAATTGTAAAAAATCTAAATTTTATTCCCTTTGACATATTTATTACTGCAAGTAGAATCTCACTAATGACCTATTCCTGT
ATGGCCTTATCCAAATCGAAATCACAAGAACAGAAGAATAATGAAAAAACAGACAAGAGTTCATTAAATCTCCCAGAAGTTGATTCAGAT
GTTGCTAAGCCCAACCAGGCATGTATTTCCACGGTGACAGCAGAAGATCTCTTAAGGAGCAGCATTTCTTTTCCTTCAGGGAAAAAAATA
GGGGTCCTCTCTCTTGAAAGTCTTCATGCATCCACAAGGTCATCTGCTAGACAAGCACTTGGTATAACTATTGTTCGGCAGCCTGGTCGA
AGAGGAACTGGTGACTTACAGCTAGAGCCTTTTCTGTACTTTATTGTGTCCCAGCCTTCCTTGCTTCTGAGTTGTCACCACAGAAAGCAG
CGAGTGGAAGTATCCATTTTTGATGCTGTGCTTAAAGGGGTGGCCTCTGATTACAAATGTATAGATCCTGGGAAGACTCTGCCTGAAGCC
CTTGATTATTGCACTGTTTGGCTACAGACAGTGCCTGGAGAAATAGACAGCAAAAGTGGTATTCCACCTTCCTTTATAACACTACAGATT
AAAGACTTTCTGAATGGACCAGCGGATGTCAATTTGGATATATCAAAGCCTTTGAAAGCAAACCTGAGTTTCACCAAACTGGATCAGATA
AACCTTTTTTTAAAGAAGATAAAAAATGCACACAGTTTGGCACATAGTGAAGAGACTTCAGCCATGTCCAACACCATGGTGAATAAGGAT
GATCTTCCAGTCTCCAAATATTACCGTGGAAAGTTGTCTAAACCCAAAATTCATGGTGATGGAGTGCAAAAGATTTCAGCTCAAGAAAAC
ATGTGGAGAGCTGTTTCCTGCTTTCAAAAAATTTCTGTTCAAACTACTCAGATTGTGATCTCCATGGAAACTGTACCCCATACCAGCAAA
CCATGCCTGTTAGCATCTCTCTCAAACCTCAATGGAAGCCTTAGTGTCAAGGCAACACAAAAAGTACCTGGCATAATTCTTGGGTCATCA
TTTCTACTCAGTATAAACGATTTTCTCCTTAAAACAAGTCTCAAAGAAAGAAGCCGCATTCTGATAGGACCATGTTGTGCTACTGCCAAT
CTGGAAGCTAAGTGGTGTAAACACAGCGGGAATCCAGGCCCAGAACAATCCATACCAAAAATATCCATTGACTTAAGAGGAGGTCTACTA
CAGGTCTTCTGGGGTCAAGAACATTTGAATTGTTTAGTTCTTCTACATGAATTACTCAATGGATACCTTAATGAGGAGGGAAATTTTGAA
GTACAAGTTTCTGAACCAGTGCCTCAAATGTCATCTCCTGTGGAAAAGAATCAGACATTTAAAAGTGAACAAAGTTCAGATGACCTACGG
ACAGGTCTATTTCAGTATGTACAGGATGCTGAATCTTTGAAATTGCCTGGGGTCTATGAAGTCTTATTTTATAATGAAACTGAAGATTGC
CCAGGGATGATGTTATGGAGATATCCAGAACCTAGAGTACTCACCCTTGTACGAATAACTCCTGTACCTTTTAACACCACAGAGGATCCA
GATATTAGCACAGCAGACCTTGGTGATGTGCTACAGGTTCCTTGTAGCTTGGAATACTGGGATGAACTCCAGAAGGTTTTTGTTGCATTT
AGAGAATTTAATCTGTCTGAAAGCAAAGTTTGTGAACTGCAGTTGCCGGATATCAATCTCGTGAATGACCAGAAGAAATTAGTATCTTCA
GATCTTTGGAGAATTGTCTTGAACAGCAGTCAAAATGGAGCTGATGACCAAAGCTCTGCAAGTGAGTCTGGTTCTCAAAGCACTTGTGAT
CCACTTGTGACTCCAACAGCCCTGGCTGCCTGTACCAGAGTTGACTCCTGCTTTACCCCATGGTTTGTCCCATCCCTTTGCGTTTCTTTC
CAGTTTGCTCACCTGGAATTCCATCTTTGTCATCACCTTGACCAACTAGGCACAGCTGCACCACAGTACCTACAGCCATTTGTTTCCGAC
AGAAATATGCCATCTGAACTAGAATACATGATTGTTTCCTTCAGAGAACCACACATGTATCTTCGACAGTGGAATAATGGTTCTGTCTGT
CAGGAGATCCAGTTCTTAGCTCAAGCAGACTGTAAACTTCTAGAGTGCAGAAATGTCACTATGCAAAGTGTGGTGAAACCCTTCAGCATC
TTCGGGCAGATGGCAGTTTCCAGCGATGTAGTGGAAAAGCTGCTTGACTGCACCGTGATAGTTGATTCTGTATTTGTAAACCTTGGACAG
CATGTAGTCCATTCACTAAACACTGCAATACAAGCTTGGCAACAGAACAAATGCCCTGAGGTAGAGGAGTTGGTCTTCAGCCATTTTGTG
ATCTGTAATGACACACAGGAGACACTGCGGTTTGGCCAGGTGGATACTGATGAAAATATTCTGCTGGCGAGTCTCCACAGTCACCAGTAC
AGCTGGCGCTCTCACAAATCCCCACAGCTGTTACACATCTGTATTGAAGGTTGGGGCAACTGGCGTTGGTCAGAGCCTTTCAGTGTGGAC
CATGCCGGGACTTTTATTAGAACAATTCAGTACAGGGGTCGAACTGCTTCTCTCATCATCAAGGTTCAGCAACTCAATGGAGTACAAAAA
CAGATTATCATCTGTGGAAGACAGATCATCTGTAGTTACTTGTCTCAAAGCATAGAACTAAAAGTCGTTCAGCATTACATTGGTCAAGAT
GGACAAGCTGTAGTTCGGGAACATTTTGACTGCCTCACAGCCAAACAGAAATTGCCTTCGTACATACTAGAAAACAATGAACTGACGGAG
CTGTGTGTGAAGGCCAAAGGAGATGAAGACTGGTCAAGAGATGTGTGCCTGGAATCCAAAGCCCCTGAGTACAGCATTGTCATTCAGGTG
CCATCTTCAAACAGTTCCATTATTTATGTCTGGTGCACAGTTTTGACTTTAGAACCCAACTCTCAAGTGCAACAACGAATGATTGTGTTC
AGCCCTCTTTTTATCATGAGGAGTCATCTTCCAGACCCCATTATCATACATTTGGAGAAAAGGAGTCTGGGATTGAGTGAAACACAAATT
ATTCCAGGAAAAGGGCAGGAAAAACCACTGCAAAACATAGAACCTGACCTTGTACATCACCTGACATTCCAAGCAAGAGAAGAATATGAT
CCTTCAGATTGTGCAGTTCCCATCTCAACATCCCTCATTAAGCAAATAGCCACTAAGGTACACCCTGGAGGCACAGTTAATCAGATCCTT
GACGAATTCTATGGGCCAGAAAAGTCGCTTCAACCCATATGGCCCTATAATAAGAAGGATTCTGACAGGAATGAACAGCTAAGTCAGTGG
GATAGCCCAATGCGAGTGAAGCTGTCAATCTGGAAGCCATATGTTAGAACTTTGTTGATAGAACTTCTGCCCTGGGCCCTGCTTATCAAT
GAATCCAAATGGGACCTCTGGCTATTTGAAGGAGAGAAAATTGTTCTACAGGTTCCTGCTGGCAAAATTATTATTCCTCCTAATTTTCAG
GAAGCTTTTCAAATTGGAATATACTGGGCAAATACAAACACTGTGCACAAGTCAGTAGCAATTAAACTGGTCCATAACCTGACATCTCCA
AAGTGGAAAGATGGAGGTAATGGTGAAGTTGTGACACTGGATGAAGAAGCGTTTGTTGATACTGAAATAAGACTTGGTGCTTTTCCAGGA
CATCAGAAGTTATGTCAGTTCTGCATTTCCTCCATGGTACAGCAAGGTATACAAATTATTCAGATTGAAGACAAGACTACAATAATCAAT
AATACACCATATCAAATATTTTATAAACCACAGCTATCTGTCTGCAATCCCCATTCTGGAAAGGAGTATTTTCGTGTTCCAGACAGTGCT
ACTTTTAGCATTTGCCCAGGTGGAGAGCAGCCTGCTATGAAATCCAGCTCCCTTCCTTGCTGGGACTTGATGCCTGACATCAGTCAGTCA
GTACTGGATGCATCCCTGCTTCAGAAACAGATCATGCTGGGCTTTTCTCCTGCCCCAGGTGCTGACAGCTCACAGTGCTGGAGCCTGCCA
GCTATAGTTAGACCAGAGTTTCCCAGACAGAGTGTGGCAGTACCCCTCGGGAATTTCCGGGAAAATGGATTCTGTACCAGGGCTATAGTG
CTGACATATCAAGAACACCTCGGAGTGACTTATTTAACCCTCTCAGAAGACCCTAGTCCTCGAGTAATTATCCACAATAGATGTCCAGTA
AAAATGCTTATAAAGGAAAACATTAAAGATATTCCAAAGTTTGAGGTTTATTGCAAAAAAATTCCCTCCGAGTGCTCAATTCATCATGAG
CTGTATCATCAGATTTCCAGTTATCCGGACTGCAAGACCAAAGACTTACTTCCAAGCCTACTTTTGAGAGTTGAACCTCTAGATGAAGTA
ACAACTGAGTGGAGTGATGCCATTGACATCAACAGTCAGGGAACACAGGTTGTGTTCCTGACTGGCTTTGGCTATGTGTATGTGGATGTT
GTACATCAGTGTGGCACAGTCTTCATCACTGTGGCCCCAGAAGGAAAAGCAGGACCTATTTTAACCAATACCAACAGAGCGCCAGAGAAG
ATTGTTACATTTAAAATGTTCATCACTCAGTTAAGCCTGGCAGTGTTTGATGACCTCACCCACCACAAAGCATCAGCTGAGCTTCTGAGA
CTCACACTGGACAACATTTTTCTCTGTGTGGCCCCGGGAGCTGGTCCCCTCCCTGGGGAAGAGCCTGTGGCTGCGTTGTTTGAACTTTAC
TGTGTGGAGATCTGCTGTGGGGACCTGCAGCTAGACAACCAGCTTTATAACAAGTCCAATTTCCACTTTGCTGTCTTAGTCTGCCAGGGA
GAAAAAGCAGAACCCATTCAGTGTTCCAAAATGCAGAGTCTCCTCATATCCAACAAAGAGTTGGAAGAATACAAGGAAAAATGTTTTATC
AAACTTTGCATCACCTTAAATGAAGGCAAGAGCATCCTCTGTGATATTAATGAGTTCAGCTTTGAATTAAAACCTGCTCGGTTATACGTG
GAAGACACATTTGTATACTACATCAAGACTTTGTTTGACACCTACCTTCCTAACAGCAGGTTGGCTGGTCACTCCACACACCTCTCCGGG
GGTAAACAGGTGTTGCCCATGCAGGTCACACAGCACGCCAGGGCCTTGGTGAATCCTGTGAAGTTACGGAAACTGGTGATCCAGCCAGTA
AATTTGCTCGTCAGCATCCACGCTTCCCTCAAGCTGTACATAGCCTCAGACCACACTCCTCTCTCCTTCTCGGTGTTTGAAAGAGGACCC
ATCTTCACCACTGCGAGGCAGCTTGTGCACGCCCTGGCAATGCACTATGCCGCTGGGGCCCTTTTTAGAGCAGGCTGGGTAGTTGGGTCT
CTGGATATTCTTGGCAGCCCTGCAAGCCTGGTGAGAAGCATCGGGAACGGGGTCGCCGACTTCTTCAGGCTTCCGTATGAGGGGCTGACC
CGGGGCCCTGGAGCCTTCGTGAGTGGCGTCTCCAGAGGGACCACATCGTTTGTAAAGCACATCTCCAAAGGTACCCTCACATCCATCACC
AACCTCGCCACAAGCCTGGCCCGGAACATGGACCGGCTCTCACTGGATGAGGAGCACTACAACCGGCAGGAGGAGTGGCGGCGGCAGCTC
CCCGAGAGCCTGGGCGAGGGGCTTCGACAGGGCCTGTCCCGGCTGGGCATCAGCCTGCTTGATAAAGTGGAGAATTTTCATGAAGAACAT
GAAAAGAATAGTCACCATATTCACAAAAATGCTGATGACAGTACTAAGAAACCCAATGCAGAAACTACAGTGGCTTCTGAAATCAAGGAA
ACAAATGATACTTGGAACTCCCAGTTTGGGAAAAGGCCAGAATCACCATCAGAAATATCTCCAATCAAGGGATCTGTTAGAACTGGTTTG
TTTGAATGGGATAATGATTTTGAAGATATCAGATCAGAAGACTGTATTTTAAGTTTGGATAGTGATCCCCTTTTGGAGATGAAGGATGAC
GATTTTAAAAATCGATTGGAAAATCTGAATGAAGCCATTGAGGAAGATATTGTACAAAGTGTTCTTAGGCCAACCAACTGTAGGACGTAC
TGTAGGGCCAATAAAACGAAATCCTCCCAAGGAGCATCAAATTTTGATAAGCTGATGGACGGCACCAGTCAGGCCTTAGCCAAAGCAAAC
AGTGAATCGAGTAAAGATGGCCTGAATCAGGCAAAGAAAGGGGGTGTAAGTTGTGGGACCAGTTTTAGAGGGACAGTTGGACGGACTAGA
GATTACACTGTTTTACATCCATCTTGCTTGTCAGTTTGTAATGTTACCATACAGGATACTATGGAACGCAGCATGGATGAGTTCACTGCA
TCCACTCCTGCAGATTTGGGAGAAGCTGGTCGTCTCAGAAAAAAGGCAGATATTGCAACTTCTAAGACTACTACTAGATTTCGACCTAGT
AATACTAAATCCAAAAAGGATGTTAAACTTGAATTTTTTGGTTTTGAAGATCATGAGACAGGAGGTGATGAAGGAGGTTCTGGAAGTTCT
AATTACAAAATTAAGTATTTTGGCTTTGATGATCTCAGTGAAAGCGAAGATGATGAAGATGATGACTGTCAAGTAGAAAGAAAGACAAGC
AAAAAAAGAACTAAAACAGCTCCATCACCCTCCTTGCAGCCTCCCCCAGAAAGCAATGATAATTCCCAGGACAGTCAGTCTGGTACTAAC
AATGCAGAAAACTTGGATTTTACAGAGGACTTGCCTGGTGTGCCTGAAAGTGTGAAGAAGCCCATAAATAAACAAGGAGATAAATCAAAG
GAAAATACCAGAAAGATTTTTAGTGGCCCCAAACGGTCACCCACAAAAGCTGTATATAATGCCAGACATTGGAATCATCCAGATTCAGAA
GAACTGCCTGGGCCACCAGTAGTAAAACCTCAGAGTGTCACAGTGAGGCTGTCTTCAAAGGAACCAAATCAAAAAGATGATGGAGTTTTT
AAGGCTCCTGCACCACCATCCAAAGTGATAAAAACTGTGACAATACCTACTCAGCCCTACCAAGATATAGTTACTGCACTGAAATGCAGA
CGAGAAGACAAAGAATTATATACTGTTGTTCAGCACGTGAAGCACTTCAACGATGTTGTAGAATTTGGTGAAAATCAAGAGTTCACTGAT
GACATTGAGTACTTGTTAAGTGGCTTAAAGAGCACTCAGCCTCTAAACACACGTTGCCTTAGTGTTATTAGCTTGGCTACTAAATGTGCC
ATGCCCAGTTTTCGAATGCACCTGAGAGCACATGGGATGGTAGCAATGGTCTTTAAAACCTTGGATGATTCCCAGCACCATCAGAATCTG
TCCCTCTGTACAGCTGCCCTCATGTATATACTGAGTAGAGATCGTTTGAACATGGATCTTGATAGAGCTAGCTTAGATCTAATGATTCGA
CTTTTGGAACTGGAACAAGATGCTTCATCAGCCAAGCTACTGAATGAAAAAGACATGAACAAAATTAAAGAAAAAATCCGAAGGCTCTGT
GAAACTGTACACAACAAGCATCTTGATCTAGAAAATATAACGACTGGGCATTTAGCTATGGAGACATTATTATCCCTTACTTCTAAACGA
GCAGGAGACTGGTTTAAAGAAGAACTCCGGCTTTTGGGTGGTCTGGATCATATTGTAGATAAAGTAAAAGAATGTGTGGATCATTTAAGT
AGAGATGAGGATGAAGAGAAACTGGTAGCCTCACTATGGGGAGCAGAGAGATGTTTACGAGTTTTAGAAAGTGTAACTGTGCATAATCCC
GAAAATCAAAGCTACTTGATAGCATATAAAGATTCCCAACTTATTGTTTCATCAGCTAAAGCATTACAGCATTGTGAAGAACTGATTCAG
CAGTACAACCGTGCTGAGGACAGCATATGCTTAGCTGACAGTAAGCCTCTGCCTCACCAGAATGTAACTAACCATGTAGGCAAAGCAGTG
GAGGACTGCATGAGGGCCATCATCGGGGTGTTGCTTAATTTAACTAATGATAATGAGTGGGGCAGCACCAAAACAGGAGAGCAGGACGGT
CTCATAGGCACAGCGCTGAACTGTGTGCTTCAGGTTCCAAAGTACCTACCTCAGGAGCAGAGATTTGATATTCGAGTGCTGGGCTTAGGT
CTGCTGATAAATCTAGTGGAGTATAGTGCTCGGAATCGGCACTGTCTTGTCAACATGGAAACATCGTGCTCTTTTGATTCTTCCATCTGT
AGTGGAGAAGGGGATGATAGTTTAAGGATAGGTGGACAAGTTCATGCTGTCCAGGCTTTAGTGCAGCTATTCCTTGAGCGAGAGCGGGCA
GCCCAGCTAGCAGAAAGTAAAACAGATGAGTTGATCAAAGATGCTCCCACCACTCAGCATGATAAGAGTGGAGAGTGGCAAGAAACAAGT
GGAGAAATACAGTGGGTGTCAACTGAAAAGACTGATGGTACAGAAGAGAAACATAAGAAGGAGGAGGAGGATGAAGAACTTGACCTCAAT
AAAGCCCTTCAGCATGCCGGCAAACACATGGAGGATTGCATTGTGGCCTCCTACACAGCACTACTTCTTGGGTGTCTCTGCCAGGAAAGT
CCAATCAATGTAACCACTGTGCGGGAATATCTGCCAGAAGGAGACTTTTCAATAATGACAGAGATGCTCAAAAAATTTTTGAGTTTTATG
AATCTCACTTGTGCTGTTGGAACAACTGGCCAGAAATCTATCTCTAGAGTGATTGAATATTTGGAACATTGCTAGCTGCTTTACCTTTGC
TTCAGGTGCTCGGTAATGCTGGAGCTATCCTTAGACAAAGAAAAGTCAAGTCATGAAAGAAGTCCTTGAAGATATACCAAGAACATTCAT
CAGTATCATTCGTGTTTGGATTTTTAAGGCCACCTGATTTCTTCGTCATGCATTCGGCATTTGCTAAATGACAGTTACTACATCAATCTG
CAACTATCAAAAATGAGGGGAAAAGGTTCAGGCTGTTAACAATTCCATGCAGTATTTAAATACATTTACTTTGGCAGAGTTTATACCCTC
CCCTTGTTTTCTTGCTTTATTCTGGGCAAGTTTGAAGGGGAAAATTTGTGCTGCTGTTAGTGCAACTGCTGTGTATGTTGAGCCACTGTT
GTCATGCCAGCCAGGTGCAAAGGCAGCTTAGCTACTGAGGTAGCGAATGTTCTGAGGACATTCTAGACAACAGCTTAGTTCCTTTTTCAG
GCTCATTTGCTTTTGCTTTTTTGTTGAATGATTCCAATCGTAAATAAAGCTTTTAATAATTTTGTGAATTTTTTGGTTGTTGTTCCCTGA
ACTACTGTCTATATTTAAAATTAGATGGAATCCAAAGATACACGGGATTAATAGTATATTTTTTTATTCTTGATTAGGTTTGGGTTATTG
AACTATTTTTTACTTTTGAGACCACAACCATATTCAATATCATACCATAATGTGTCATAGCTATAGGCACAAGAAAAACAACAGTTTGAG
AGAATATTATATAAGATGATGTGCCCTGTTAAAAGGAGGAGGCAAAATAGTCAAACCCAGGGTAGTTTACACTTAATGCTAGGGAGGCTC
TTAAAACATTATTAGATTTTGAGGAAAGACTCTCTAGATATATTTTCTAATGTTCAGTACAATAAATATAAGGAAGCTAAAACACCAATG
TGGAATTCCTGTTTCCAGATAACATGTATATTCTTCTATAGAGTGACAGGATCAATTGCATAAGCGCAAAGCCTTAAATTGCTGGTTTAG
AGAAGACCCTTTTTTCATTCAGATTCTTTGTTCGTAGAGCAGTTATTTGAAAAACAGTTATGGAACACAAAACATTTTATAGATTTAATA
TCATAACATTGCAAATTTTTCTTGTATTATTCACACCACTGGTTATACTTTTTTTTTTCCTTTTTTATTGATTGGGCCTGAATACAGGCT
TTCTAGAGATCTTTTTCATTAATACTTTTAAATACCTTTCAGGTAGTTACATCATGTTTCTTCATTGGATTTGTAAAACTTGAAGCCATA
AAAATATTAGTTTGGTGTGTATTGGGGAAAATAGCTAAAAGTCTAATTTTTACCCATTTAGACTTTGTTATTTCCTTGTATAAAGTGACA
AATCGGGGCTCTTGTATCAGTGCCAGCTGTAATGTTTTTAAATGCAGTGGCTGCCTTCTATTGTCTTCCTATTTTTGATAATGCAGATTG
TTGGGAAATCTGTAAGGAAGTAACTGATTCCAGGCAAATTGTTTTCTTCCTTCTACCCACCCCAACCCCTACCCATCACCTTTTAAGAAC
ATAGTACGCCAGTGTAACGTGGGAACCATTGAGATTGTATTTGCCCTGAGTATTAAAGCTAGCTTAGCAAAATACTTTTAAAAACATATT
GGTAAATGATACCCGTAAAATTAAATTAGTTATATTTTATTTTAAAATGCAAAATACATTGATATTTATTAATCATTGGATTTAGGGAAA
GGGACAGATTTTTGGTGAACCTGACTTGTGGCAGATGGTAAGGAATATTATAAAACATTTGGATGAGAACAATCAGGGCGAACTGCATTT
TTCTGTTACACTGGTAATCATTTGAAAATTGATTTACCTCAGTGTTTAACAGTTTTTTGTTTTGTTTTGTTTTTTAAATAATAACTAATT
GTCGAGCACTGATAGAGATGCAGATTTTGGTGGGGGGAGGTGGTGGGGGAGATAATCACTTCACCAACTGCAGTGCATTTGTGTGTTTTT
AACCCTCAGAGAACTCTGCATTTTAGGGTACTTGAGGCTGACTTAACTAAAAGTTTTAAAGTAACCTTTTTTCCATTGTAAATATTTCTG
TAAATACTACCAATTGGAAATTAGAACAGTAGAGTACTTTTCTGAATCCAATCCTATTTTTATTTTATACAGTATTTCTCAGCTGTGATC
TTTGGAGCAAAAGCCAACGGCAGGAAAAAATAGTTTGTACCAGTTTCATGAAGTATGTCTTTGGGTTTTTGTAAATAATTTTAACTCAAA

>98300_98300_2_VPS13B-WAPAL_VPS13B_chr8_100874174_ENST00000358544_WAPAL_chr10_88260500_ENST00000298767_length(amino acids)=4787AA_BP=3749
MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELRIHVPWTKLGSEPVVITINTMECIL
KLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYT
VGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQ
LPMFIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQDEEQPQGWVSWAWSFVPAIVSYD
DGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRFGAFYMDY
LYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPEEVA
LLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQ
PSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLLLQA
IYQSWSHLGNVSSSAVIEALINEIFLSIGVKSKNPLPTLEGSIQNVELKYCSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSD
TKDLHSTKWLNESRKPESLLAPDLMAFTIQVPQYIDYCHNSGAVLLCSIQGLAVNIDPILYTWLIYQPQKRTSRHMQQQPVVAVPLVMPV
CRRKEDEVSIGSAPLAKQQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNISESCRSPEERMKEFIGIVWNAVKHLTLQLEVQSCCVFI
PNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISAGHKYMEPLQEIPFVIPRPILEEGDAFPWTISLHNFSIYTLLGKQ
VTLCLVEPMGCTSTLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDIMNKVWNKIQKRGNLNLSPTSPETMAGPV
PTSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEESPFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGTEVC
MVSELEDLSASIDVQDVYTKVKCKIESFNIDHYRSSLGEECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFSNCSGFFPSTTTKLLD
GTHQQHGFLSLTYTKAVTKNVRHKLTSRNERRSFHKLSEGLMDGSPHFLHEILLSAQAFDIVLYFPLLNAIASIFQAKLPKTQKEKRKSP
GQPMRTHTLTSRNLPLIYVNTSVIRIFIPKTEEMQPTVEANQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRDPGS
EIEDRQYQIDLQSINIGTAQWHQLKPEKESVSGGVVTETERNSQNPALEWNMASSIRRHQERRAILTPVLTDFSVRITGAPAVIFTKVVS
PENLHTEEILVCGHSLEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQKKVDIFDGGMAETSSRYSGAQDSGIGSDS
VKIRIVQIEQHSGASQHRIARPSRQSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKSQEQKNNEKTDKSSLNLPEVDSDVAKPNQA
CISTVTAEDLLRSSISFPSGKKIGVLSLESLHASTRSSARQALGITIVRQPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIF
DAVLKGVASDYKCIDPGKTLPEALDYCTVWLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFTKLDQINLFLKKI
KNAHSLAHSEETSAMSNTMVNKDDLPVSKYYRGKLSKPKIHGDGVQKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPCLLASL
SNLNGSLSVKATQKVPGIILGSSFLLSINDFLLKTSLKERSRILIGPCCATANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVFWGQE
HLNCLVLLHELLNGYLNEEGNFEVQVSEPVPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQDAESLKLPGVYEVLFYNETEDCPGMMLWR
YPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQVPCSLEYWDELQKVFVAFREFNLSESKVCELQLPDINLVNDQKKLVSSDLWRIVL
NSSQNGADDQSSASESGSQSTCDPLVTPTALAACTRVDSCFTPWFVPSLCVSFQFAHLEFHLCHHLDQLGTAAPQYLQPFVSDRNMPSEL
EYMIVSFREPHMYLRQWNNGSVCQEIQFLAQADCKLLECRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNLGQHVVHSLN
TAIQAWQQNKCPEVEELVFSHFVICNDTQETLRFGQVDTDENILLASLHSHQYSWRSHKSPQLLHICIEGWGNWRWSEPFSVDHAGTFIR
TIQYRGRTASLIIKVQQLNGVQKQIIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTELCVKAKG
DEDWSRDVCLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFSPLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQE
KPLQNIEPDLVHHLTFQAREEYDPSDCAVPISTSLIKQIATKVHPGGTVNQILDEFYGPEKSLQPIWPYNKKDSDRNEQLSQWDSPMRVK
LSIWKPYVRTLLIELLPWALLINESKWDLWLFEGEKIVLQVPAGKIIIPPNFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGN
GEVVTLDEEAFVDTEIRLGAFPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVCNPHSGKEYFRVPDSATFSICPG
GEQPAMKSSSLPCWDLMPDISQSVLDASLLQKQIMLGFSPAPGADSSQCWSLPAIVRPEFPRQSVAVPLGNFRENGFCTRAIVLTYQEHL
GVTYLTLSEDPSPRVIIHNRCPVKMLIKENIKDIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSLLLRVEPLDEVTTEWSDA
IDINSQGTQVVFLTGFGYVYVDVVHQCGTVFITVAPEGKAGPILTNTNRAPEKIVTFKMFITQLSLAVFDDLTHHKASAELLRLTLDNIF
LCVAPGAGPLPGEEPVAALFELYCVEICCGDLQLDNQLYNKSNFHFAVLVCQGEKAEPIQCSKMQSLLISNKELEEYKEKCFIKLCITLN
EGKSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSRLAGHSTHLSGGKQVLPMQVTQHARALVNPVKLRKLVIQPVNLLVSIH
ASLKLYIASDHTPLSFSVFERGPIFTTARQLVHALAMHYAAGALFRAGWVVGSLDILGSPASLVRSIGNGVADFFRLPYEGLTRGPGAFV
SGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQLPESLGEGLRQGLSRLGISLLDKVENFHEEHEKNSHHI
HKNADDSTKKPNAETTVASEIKETNDTWNSQFGKRPESPSEISPIKGSVRTGLFEWDNDFEDIRSEDCILSLDSDPLLEMKDDDFKNRLE
NLNEAIEEDIVQSVLRPTNCRTYCRANKTKSSQGASNFDKLMDGTSQALAKANSESSKDGLNQAKKGGVSCGTSFRGTVGRTRDYTVLHP
SCLSVCNVTIQDTMERSMDEFTASTPADLGEAGRLRKKADIATSKTTTRFRPSNTKSKKDVKLEFFGFEDHETGGDEGGSGSSNYKIKYF
GFDDLSESEDDEDDDCQVERKTSKKRTKTAPSPSLQPPPESNDNSQDSQSGTNNAENLDFTEDLPGVPESVKKPINKQGDKSKENTRKIF
SGPKRSPTKAVYNARHWNHPDSEELPGPPVVKPQSVTVRLSSKEPNQKDDGVFKAPAPPSKVIKTVTIPTQPYQDIVTALKCRREDKELY
TVVQHVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPLNTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQNLSLCTAAL
MYILSRDRLNMDLDRASLDLMIRLLELEQDASSAKLLNEKDMNKIKEKIRRLCETVHNKHLDLENITTGHLAMETLLSLTSKRAGDWFKE
ELRLLGGLDHIVDKVKECVDHLSRDEDEEKLVASLWGAERCLRVLESVTVHNPENQSYLIAYKDSQLIVSSAKALQHCEELIQQYNRAED
SICLADSKPLPHQNVTNHVGKAVEDCMRAIIGVLLNLTNDNEWGSTKTGEQDGLIGTALNCVLQVPKYLPQEQRFDIRVLGLGLLINLVE
YSARNRHCLVNMETSCSFDSSICSGEGDDSLRIGGQVHAVQALVQLFLERERAAQLAESKTDELIKDAPTTQHDKSGEWQETSGEIQWVS
TEKTDGTEEKHKKEEEDEELDLNKALQHAGKHMEDCIVASYTALLLGCLCQESPINVTTVREYLPEGDFSIMTEMLKKFLSFMNLTCAVG

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Fusion Gene PPI Analysis for VPS13B-WAPAL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VPS13B-WAPAL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VPS13B-WAPAL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource