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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VPS53-NXN (FusionGDB2 ID:98486)

Fusion Gene Summary for VPS53-NXN

check button Fusion gene summary
Fusion gene informationFusion gene name: VPS53-NXN
Fusion gene ID: 98486
HgeneTgene
Gene symbol

VPS53

NXN

Gene ID

55275

64359

Gene nameVPS53 subunit of GARP complexnucleoredoxin
SynonymsHCCS1|PCH2E|hVps53L|pp13624NRX|RRS2|TRG-4
Cytomap

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 53 homologVPS53, GARP complex subunitnucleoredoxinnucleoredoxin 1
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000291074, ENST00000401468, 
ENST00000437048, ENST00000571805, 
ENST00000574029, ENST00000446250, 
ENST00000576149, 		ENST00000537628, 
ENST00000575801, ENST00000577098, 
ENST00000538650, ENST00000336868, 
Fusion gene scores* DoF score18 X 15 X 14=378017 X 15 X 5=1275
# samples 2420
** MAII scorelog2(24/3780*10)=-3.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1275*10)=-2.6724253419715
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VPS53 [Title/Abstract] AND NXN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNXN(722678)-VPS53(465985), # samples:1
NXN(722679)-VPS53(465985), # samples:1
VPS53(613773)-NXN(729318), # samples:1
Anticipated loss of major functional domain due to fusion event.NXN-VPS53 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NXN-VPS53 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across VPS53 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NXN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-50-5066-02AVPS53chr17

613773

-NXNchr17

729318

-


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Fusion Gene ORF analysis for VPS53-NXN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000291074ENST00000537628VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000291074ENST00000575801VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000291074ENST00000577098VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000401468ENST00000537628VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000401468ENST00000575801VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000401468ENST00000577098VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000437048ENST00000537628VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000437048ENST00000575801VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000437048ENST00000577098VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000571805ENST00000537628VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000571805ENST00000575801VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000571805ENST00000577098VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000574029ENST00000537628VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000574029ENST00000575801VPS53chr17

613773

-NXNchr17

729318

-
5CDS-5UTRENST00000574029ENST00000577098VPS53chr17

613773

-NXNchr17

729318

-
5CDS-intronENST00000291074ENST00000538650VPS53chr17

613773

-NXNchr17

729318

-
5CDS-intronENST00000401468ENST00000538650VPS53chr17

613773

-NXNchr17

729318

-
5CDS-intronENST00000437048ENST00000538650VPS53chr17

613773

-NXNchr17

729318

-
5CDS-intronENST00000571805ENST00000538650VPS53chr17

613773

-NXNchr17

729318

-
5CDS-intronENST00000574029ENST00000538650VPS53chr17

613773

-NXNchr17

729318

-
5UTR-3CDSENST00000446250ENST00000336868VPS53chr17

613773

-NXNchr17

729318

-
5UTR-5UTRENST00000446250ENST00000537628VPS53chr17

613773

-NXNchr17

729318

-
5UTR-5UTRENST00000446250ENST00000575801VPS53chr17

613773

-NXNchr17

729318

-
5UTR-5UTRENST00000446250ENST00000577098VPS53chr17

613773

-NXNchr17

729318

-
5UTR-intronENST00000446250ENST00000538650VPS53chr17

613773

-NXNchr17

729318

-
In-frameENST00000291074ENST00000336868VPS53chr17

613773

-NXNchr17

729318

-
In-frameENST00000401468ENST00000336868VPS53chr17

613773

-NXNchr17

729318

-
In-frameENST00000437048ENST00000336868VPS53chr17

613773

-NXNchr17

729318

-
In-frameENST00000571805ENST00000336868VPS53chr17

613773

-NXNchr17

729318

-
In-frameENST00000574029ENST00000336868VPS53chr17

613773

-NXNchr17

729318

-
intron-3CDSENST00000576149ENST00000336868VPS53chr17

613773

-NXNchr17

729318

-
intron-5UTRENST00000576149ENST00000537628VPS53chr17

613773

-NXNchr17

729318

-
intron-5UTRENST00000576149ENST00000575801VPS53chr17

613773

-NXNchr17

729318

-
intron-5UTRENST00000576149ENST00000577098VPS53chr17

613773

-NXNchr17

729318

-
intron-intronENST00000576149ENST00000538650VPS53chr17

613773

-NXNchr17

729318

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000437048VPS53chr17613773-ENST00000336868NXNchr17729318-28993151471262371
ENST00000574029VPS53chr17613773-ENST00000336868NXNchr17729318-28732891211236371
ENST00000291074VPS53chr17613773-ENST00000336868NXNchr17729318-28863021341249371
ENST00000571805VPS53chr17613773-ENST00000336868NXNchr17729318-28893051371252371
ENST00000401468VPS53chr17613773-ENST00000336868NXNchr17729318-275216801115371

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000437048ENST00000336868VPS53chr17613773-NXNchr17729318-0.0039263170.9960737
ENST00000574029ENST00000336868VPS53chr17613773-NXNchr17729318-0.0037625380.9962374
ENST00000291074ENST00000336868VPS53chr17613773-NXNchr17729318-0.0039437620.9960562
ENST00000571805ENST00000336868VPS53chr17613773-NXNchr17729318-0.0039119460.996088
ENST00000401468ENST00000336868VPS53chr17613773-NXNchr17729318-0.0037415210.9962585

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Fusion Genomic Features for VPS53-NXN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VPS53-NXN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:722678/chr17:465985)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNXNchr17:613773chr17:729318ENST0000033686808167_321120436.0DomainThioredoxin
TgeneNXNchr17:613773chr17:729318ENST0000053762808167_3210187.0DomainThioredoxin
TgeneNXNchr17:613773chr17:729318ENST0000057580108167_32112328.0DomainThioredoxin

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVPS53chr17:613773chr17:729318ENST00000291074-21897_13856671.0Coiled coilOntology_term=ECO:0000255
HgeneVPS53chr17:613773chr17:729318ENST00000437048-22297_13856833.0Coiled coilOntology_term=ECO:0000255
HgeneVPS53chr17:613773chr17:729318ENST00000571805-21997_13856700.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for VPS53-NXN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98486_98486_1_VPS53-NXN_VPS53_chr17_613773_ENST00000291074_NXN_chr17_729318_ENST00000336868_length(transcript)=2886nt_BP=302nt
GGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGGCCT
GAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAGCCG
TGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTGTTG
AGTATATCAATACCCTGTTCCCAACCGAGCAACTCAAACTTTGGAACAAATACCGAATTTCCAACATTCCATCACTAATATTCCTCGACG
CCACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTGATCCGAGATGACCCAGAAGGTCTGGAGTTCCCCTGGGGACCGAAACCCT
TCAGGGAAGTCATTGCAGGGCCCTTGCTTAGAAACAATGGGCAGTCTCTGGAGAGCAGCAGCCTGGAGGGGTCTCACGTGGGCGTCTATT
TCTCCGCACATTGGTGTCCGCCCTGCCGAAGCCTCACCCGGGTCCTGGTGGAATCCTACCGGAAGATCAAGGAGGCAGGCCAGAACTTCG
AGATCATCTTCGTTAGTGCAGACAGGTCGGAGGAGTCCTTCAAACAGTACTTCAGTGAGATGCCCTGGCTCGCCGTCCCCTACACGGATG
AGGCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAAGGCATCCCCACGCTCATCATGCTGGACCCGCAGGGCGAGGTGATCACGC
GGCAGGGGCGGGTGGAGGTGCTGAACGACGAGGACTGCCGGGAGTTCCCCTGGCACCCCAAGCCCGTGCTGGAGCTCTCCGACTCCAACG
CCGCGCAGCTTAACGAGGGCCCCTGCCTCGTCCTTTTTGTAGATTCTGAGGATGACGGAGAGTCCGAGGCGGCCAAGCAGCTGATTCAGC
CGATAGCTGAGAAAATCATTGCCAAGTACAAAGCCAAAGAGGAGGAGGCACCCCTTCTGTTCTTCGTAGCCGGGGAGGATGACATGACTG
ACTCCCTGCGAGATTACACCAACCTGCCTGAGGCTGCCCCTTTGCTCACCATCCTGGACATGTCAGCCCGGGCCAAGTACGTGATGGACG
TGGAGGAGATCACCCCCGCCATCGTGGAGGCCTTTGTGAATGACTTCCTAGCAGAGAAGCTCAAACCGGAGCCCATCTAGCGTGGCTCCG
GCCTCCTGAGACGTTATTTAAAACTCAGCCTTCTCCTCCTCCCCCTCCTTCCTTCCGCCCTTGGACTTACCCAGCGTGCCCCGAATCCCA
CCACCCAAGTGTCCAGCCTCTCTGTGGTGCCTTGTTTCTGCAGTAAACTCCTCAGCCAGCACCCTGGGGTGTGGAATCAGCAGCGGCAGA
GTCCACCGTGTTTGGAGACTCTGTTTGGGAGCACGGGATGGCCGGGGGCCCGGCCAGAGCGGGGCTGCATGGCTTTCGCAAAGTCACTAG
CTTTTGGTGAAGGATCTGCCAGGGTGTCCTGGGCAGAGTGAGCGTGGAGGGCCGGTGGGTCCCGCTCGGGCTCTGACTCTGACGTCGGCA
CACACGGCCCCGGACGGCCAGAGGGGAACCGCCGGGTGACACCTGCGTGGAGGCTGAGCTGAGAAAGGGCCTCCGCTTAGAGCTGCGGGT
GAGGACGTCCTTTTCTAAGCAACACAGTCTTCCTCGGTCTGAGAGAAAAGCAGCCCACTCTTGTGTTCTCAGGCAGGGGATCTCCAAATG
CAAAAGGAAGCTTGTAGAGGTTTTTTGGGTGAGAAGAAAAATGTAGCTAAGGTAATGGTTCATATCATACAAACAGCTCCCACGATCCTG
AAATTCTGTTAACGAATCCTTCTCTTTGGACATCTTCCCAAGAAACTTAGCCCTGAGTCCTAGGAGGAGCACCTCTGCACCAGCACGGAC
CTCTCGCTCCACCCAGCTCTGTGCCCAAGGCCCCTGATCTCTGCTGAGGTGCCCACACCCACGTTCGATCACCCCTGCCATTCCCTTTTA
TTTTCTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACCATCTTGGCTCACTTCAACCTCCGCCCCCAAG
GTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCCGCCACCGTACCTGGCTAATTTTTGTATTTTTAGTAG
AGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTA
CAGGCGTGAGCCGCCGTGCCCGGCCCCCTTTTCTTTTCAAAGCAGAACTACAAAGATGAGAAATTACCAGAAGCCTCGCCTTTTCCTAAG
CACCAGCGGAAGGAGCTGTGCCCCGGGATGGAGTGAGGGTGGAGGGCGCGTCAGCCACGGGTGGGCCTTGTGTCGCCTTGTATCGGCCCA
GGTAGGTTGTTGGCCTCTTACTTGGGCTGACCTGACCCCCGAAAGAGAAACAGACAACTCTGTTCTCAGGATTGGGGATGGACGGCTTCG
GCCAAGCGTTTTAGCCTCATTCACTCAGGCCCCACTCAGCACTCTGCCAGCCAAGACCATTGATTTGGAAAATCCGGTCCCCACCCGCTA
ATGAGCTGTTGACACTGTTGTTCCTTGCTGAATTGGATTGTTGACTTGTAGTTCAGAGGCGTACAACTAGTTGGCGATTAGACTTGTTAT
GTGATGTTACCAGCCTGAAATGCGATCACCCCGTAGGAAATAAAGCAGGCATCTCTGGACCTCATCCACCCTGGGCCTCTGCTGTCCTTG

>98486_98486_1_VPS53-NXN_VPS53_chr17_613773_ENST00000291074_NXN_chr17_729318_ENST00000336868_length(amino acids)=371AA_BP=55
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVI
RDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFK
QYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVD
SEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEAFVND

--------------------------------------------------------------
>98486_98486_2_VPS53-NXN_VPS53_chr17_613773_ENST00000401468_NXN_chr17_729318_ENST00000336868_length(transcript)=2752nt_BP=168nt
ATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAGCCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTG
TTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTGTTGAGTATATCAATACCCTGTTCCCAACCGAGCAACTCAAACTTTGG
AACAAATACCGAATTTCCAACATTCCATCACTAATATTCCTCGACGCCACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTGATC
CGAGATGACCCAGAAGGTCTGGAGTTCCCCTGGGGACCGAAACCCTTCAGGGAAGTCATTGCAGGGCCCTTGCTTAGAAACAATGGGCAG
TCTCTGGAGAGCAGCAGCCTGGAGGGGTCTCACGTGGGCGTCTATTTCTCCGCACATTGGTGTCCGCCCTGCCGAAGCCTCACCCGGGTC
CTGGTGGAATCCTACCGGAAGATCAAGGAGGCAGGCCAGAACTTCGAGATCATCTTCGTTAGTGCAGACAGGTCGGAGGAGTCCTTCAAA
CAGTACTTCAGTGAGATGCCCTGGCTCGCCGTCCCCTACACGGATGAGGCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAAGGC
ATCCCCACGCTCATCATGCTGGACCCGCAGGGCGAGGTGATCACGCGGCAGGGGCGGGTGGAGGTGCTGAACGACGAGGACTGCCGGGAG
TTCCCCTGGCACCCCAAGCCCGTGCTGGAGCTCTCCGACTCCAACGCCGCGCAGCTTAACGAGGGCCCCTGCCTCGTCCTTTTTGTAGAT
TCTGAGGATGACGGAGAGTCCGAGGCGGCCAAGCAGCTGATTCAGCCGATAGCTGAGAAAATCATTGCCAAGTACAAAGCCAAAGAGGAG
GAGGCACCCCTTCTGTTCTTCGTAGCCGGGGAGGATGACATGACTGACTCCCTGCGAGATTACACCAACCTGCCTGAGGCTGCCCCTTTG
CTCACCATCCTGGACATGTCAGCCCGGGCCAAGTACGTGATGGACGTGGAGGAGATCACCCCCGCCATCGTGGAGGCCTTTGTGAATGAC
TTCCTAGCAGAGAAGCTCAAACCGGAGCCCATCTAGCGTGGCTCCGGCCTCCTGAGACGTTATTTAAAACTCAGCCTTCTCCTCCTCCCC
CTCCTTCCTTCCGCCCTTGGACTTACCCAGCGTGCCCCGAATCCCACCACCCAAGTGTCCAGCCTCTCTGTGGTGCCTTGTTTCTGCAGT
AAACTCCTCAGCCAGCACCCTGGGGTGTGGAATCAGCAGCGGCAGAGTCCACCGTGTTTGGAGACTCTGTTTGGGAGCACGGGATGGCCG
GGGGCCCGGCCAGAGCGGGGCTGCATGGCTTTCGCAAAGTCACTAGCTTTTGGTGAAGGATCTGCCAGGGTGTCCTGGGCAGAGTGAGCG
TGGAGGGCCGGTGGGTCCCGCTCGGGCTCTGACTCTGACGTCGGCACACACGGCCCCGGACGGCCAGAGGGGAACCGCCGGGTGACACCT
GCGTGGAGGCTGAGCTGAGAAAGGGCCTCCGCTTAGAGCTGCGGGTGAGGACGTCCTTTTCTAAGCAACACAGTCTTCCTCGGTCTGAGA
GAAAAGCAGCCCACTCTTGTGTTCTCAGGCAGGGGATCTCCAAATGCAAAAGGAAGCTTGTAGAGGTTTTTTGGGTGAGAAGAAAAATGT
AGCTAAGGTAATGGTTCATATCATACAAACAGCTCCCACGATCCTGAAATTCTGTTAACGAATCCTTCTCTTTGGACATCTTCCCAAGAA
ACTTAGCCCTGAGTCCTAGGAGGAGCACCTCTGCACCAGCACGGACCTCTCGCTCCACCCAGCTCTGTGCCCAAGGCCCCTGATCTCTGC
TGAGGTGCCCACACCCACGTTCGATCACCCCTGCCATTCCCTTTTATTTTCTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCCAGGCTG
GAGTGCAGTGGCACCATCTTGGCTCACTTCAACCTCCGCCCCCAAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATT
ACAGGCACCCGCCACCGTACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTG
ACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCGCCGTGCCCGGCCCCCTTTTCTTTTCAAAGCA
GAACTACAAAGATGAGAAATTACCAGAAGCCTCGCCTTTTCCTAAGCACCAGCGGAAGGAGCTGTGCCCCGGGATGGAGTGAGGGTGGAG
GGCGCGTCAGCCACGGGTGGGCCTTGTGTCGCCTTGTATCGGCCCAGGTAGGTTGTTGGCCTCTTACTTGGGCTGACCTGACCCCCGAAA
GAGAAACAGACAACTCTGTTCTCAGGATTGGGGATGGACGGCTTCGGCCAAGCGTTTTAGCCTCATTCACTCAGGCCCCACTCAGCACTC
TGCCAGCCAAGACCATTGATTTGGAAAATCCGGTCCCCACCCGCTAATGAGCTGTTGACACTGTTGTTCCTTGCTGAATTGGATTGTTGA
CTTGTAGTTCAGAGGCGTACAACTAGTTGGCGATTAGACTTGTTATGTGATGTTACCAGCCTGAAATGCGATCACCCCGTAGGAAATAAA

>98486_98486_2_VPS53-NXN_VPS53_chr17_613773_ENST00000401468_NXN_chr17_729318_ENST00000336868_length(amino acids)=371AA_BP=55
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVI
RDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFK
QYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVD
SEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEAFVND

--------------------------------------------------------------
>98486_98486_3_VPS53-NXN_VPS53_chr17_613773_ENST00000437048_NXN_chr17_729318_ENST00000336868_length(transcript)=2899nt_BP=315nt
GAAGTGCCGGAGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGG
CGGCTGGAGGCCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAG
GAGCTGGAAGCCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGAT
TTCAATGCTGTTGAGTATATCAATACCCTGTTCCCAACCGAGCAACTCAAACTTTGGAACAAATACCGAATTTCCAACATTCCATCACTA
ATATTCCTCGACGCCACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTGATCCGAGATGACCCAGAAGGTCTGGAGTTCCCCTGG
GGACCGAAACCCTTCAGGGAAGTCATTGCAGGGCCCTTGCTTAGAAACAATGGGCAGTCTCTGGAGAGCAGCAGCCTGGAGGGGTCTCAC
GTGGGCGTCTATTTCTCCGCACATTGGTGTCCGCCCTGCCGAAGCCTCACCCGGGTCCTGGTGGAATCCTACCGGAAGATCAAGGAGGCA
GGCCAGAACTTCGAGATCATCTTCGTTAGTGCAGACAGGTCGGAGGAGTCCTTCAAACAGTACTTCAGTGAGATGCCCTGGCTCGCCGTC
CCCTACACGGATGAGGCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAAGGCATCCCCACGCTCATCATGCTGGACCCGCAGGGC
GAGGTGATCACGCGGCAGGGGCGGGTGGAGGTGCTGAACGACGAGGACTGCCGGGAGTTCCCCTGGCACCCCAAGCCCGTGCTGGAGCTC
TCCGACTCCAACGCCGCGCAGCTTAACGAGGGCCCCTGCCTCGTCCTTTTTGTAGATTCTGAGGATGACGGAGAGTCCGAGGCGGCCAAG
CAGCTGATTCAGCCGATAGCTGAGAAAATCATTGCCAAGTACAAAGCCAAAGAGGAGGAGGCACCCCTTCTGTTCTTCGTAGCCGGGGAG
GATGACATGACTGACTCCCTGCGAGATTACACCAACCTGCCTGAGGCTGCCCCTTTGCTCACCATCCTGGACATGTCAGCCCGGGCCAAG
TACGTGATGGACGTGGAGGAGATCACCCCCGCCATCGTGGAGGCCTTTGTGAATGACTTCCTAGCAGAGAAGCTCAAACCGGAGCCCATC
TAGCGTGGCTCCGGCCTCCTGAGACGTTATTTAAAACTCAGCCTTCTCCTCCTCCCCCTCCTTCCTTCCGCCCTTGGACTTACCCAGCGT
GCCCCGAATCCCACCACCCAAGTGTCCAGCCTCTCTGTGGTGCCTTGTTTCTGCAGTAAACTCCTCAGCCAGCACCCTGGGGTGTGGAAT
CAGCAGCGGCAGAGTCCACCGTGTTTGGAGACTCTGTTTGGGAGCACGGGATGGCCGGGGGCCCGGCCAGAGCGGGGCTGCATGGCTTTC
GCAAAGTCACTAGCTTTTGGTGAAGGATCTGCCAGGGTGTCCTGGGCAGAGTGAGCGTGGAGGGCCGGTGGGTCCCGCTCGGGCTCTGAC
TCTGACGTCGGCACACACGGCCCCGGACGGCCAGAGGGGAACCGCCGGGTGACACCTGCGTGGAGGCTGAGCTGAGAAAGGGCCTCCGCT
TAGAGCTGCGGGTGAGGACGTCCTTTTCTAAGCAACACAGTCTTCCTCGGTCTGAGAGAAAAGCAGCCCACTCTTGTGTTCTCAGGCAGG
GGATCTCCAAATGCAAAAGGAAGCTTGTAGAGGTTTTTTGGGTGAGAAGAAAAATGTAGCTAAGGTAATGGTTCATATCATACAAACAGC
TCCCACGATCCTGAAATTCTGTTAACGAATCCTTCTCTTTGGACATCTTCCCAAGAAACTTAGCCCTGAGTCCTAGGAGGAGCACCTCTG
CACCAGCACGGACCTCTCGCTCCACCCAGCTCTGTGCCCAAGGCCCCTGATCTCTGCTGAGGTGCCCACACCCACGTTCGATCACCCCTG
CCATTCCCTTTTATTTTCTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACCATCTTGGCTCACTTCAAC
CTCCGCCCCCAAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCCGCCACCGTACCTGGCTAATTTTT
GTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAA
AGTGCTGGGATTACAGGCGTGAGCCGCCGTGCCCGGCCCCCTTTTCTTTTCAAAGCAGAACTACAAAGATGAGAAATTACCAGAAGCCTC
GCCTTTTCCTAAGCACCAGCGGAAGGAGCTGTGCCCCGGGATGGAGTGAGGGTGGAGGGCGCGTCAGCCACGGGTGGGCCTTGTGTCGCC
TTGTATCGGCCCAGGTAGGTTGTTGGCCTCTTACTTGGGCTGACCTGACCCCCGAAAGAGAAACAGACAACTCTGTTCTCAGGATTGGGG
ATGGACGGCTTCGGCCAAGCGTTTTAGCCTCATTCACTCAGGCCCCACTCAGCACTCTGCCAGCCAAGACCATTGATTTGGAAAATCCGG
TCCCCACCCGCTAATGAGCTGTTGACACTGTTGTTCCTTGCTGAATTGGATTGTTGACTTGTAGTTCAGAGGCGTACAACTAGTTGGCGA
TTAGACTTGTTATGTGATGTTACCAGCCTGAAATGCGATCACCCCGTAGGAAATAAAGCAGGCATCTCTGGACCTCATCCACCCTGGGCC

>98486_98486_3_VPS53-NXN_VPS53_chr17_613773_ENST00000437048_NXN_chr17_729318_ENST00000336868_length(amino acids)=371AA_BP=55
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVI
RDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFK
QYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVD
SEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEAFVND

--------------------------------------------------------------
>98486_98486_4_VPS53-NXN_VPS53_chr17_613773_ENST00000571805_NXN_chr17_729318_ENST00000336868_length(transcript)=2889nt_BP=305nt
AGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGG
CCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAG
CCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTG
TTGAGTATATCAATACCCTGTTCCCAACCGAGCAACTCAAACTTTGGAACAAATACCGAATTTCCAACATTCCATCACTAATATTCCTCG
ACGCCACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTGATCCGAGATGACCCAGAAGGTCTGGAGTTCCCCTGGGGACCGAAAC
CCTTCAGGGAAGTCATTGCAGGGCCCTTGCTTAGAAACAATGGGCAGTCTCTGGAGAGCAGCAGCCTGGAGGGGTCTCACGTGGGCGTCT
ATTTCTCCGCACATTGGTGTCCGCCCTGCCGAAGCCTCACCCGGGTCCTGGTGGAATCCTACCGGAAGATCAAGGAGGCAGGCCAGAACT
TCGAGATCATCTTCGTTAGTGCAGACAGGTCGGAGGAGTCCTTCAAACAGTACTTCAGTGAGATGCCCTGGCTCGCCGTCCCCTACACGG
ATGAGGCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAAGGCATCCCCACGCTCATCATGCTGGACCCGCAGGGCGAGGTGATCA
CGCGGCAGGGGCGGGTGGAGGTGCTGAACGACGAGGACTGCCGGGAGTTCCCCTGGCACCCCAAGCCCGTGCTGGAGCTCTCCGACTCCA
ACGCCGCGCAGCTTAACGAGGGCCCCTGCCTCGTCCTTTTTGTAGATTCTGAGGATGACGGAGAGTCCGAGGCGGCCAAGCAGCTGATTC
AGCCGATAGCTGAGAAAATCATTGCCAAGTACAAAGCCAAAGAGGAGGAGGCACCCCTTCTGTTCTTCGTAGCCGGGGAGGATGACATGA
CTGACTCCCTGCGAGATTACACCAACCTGCCTGAGGCTGCCCCTTTGCTCACCATCCTGGACATGTCAGCCCGGGCCAAGTACGTGATGG
ACGTGGAGGAGATCACCCCCGCCATCGTGGAGGCCTTTGTGAATGACTTCCTAGCAGAGAAGCTCAAACCGGAGCCCATCTAGCGTGGCT
CCGGCCTCCTGAGACGTTATTTAAAACTCAGCCTTCTCCTCCTCCCCCTCCTTCCTTCCGCCCTTGGACTTACCCAGCGTGCCCCGAATC
CCACCACCCAAGTGTCCAGCCTCTCTGTGGTGCCTTGTTTCTGCAGTAAACTCCTCAGCCAGCACCCTGGGGTGTGGAATCAGCAGCGGC
AGAGTCCACCGTGTTTGGAGACTCTGTTTGGGAGCACGGGATGGCCGGGGGCCCGGCCAGAGCGGGGCTGCATGGCTTTCGCAAAGTCAC
TAGCTTTTGGTGAAGGATCTGCCAGGGTGTCCTGGGCAGAGTGAGCGTGGAGGGCCGGTGGGTCCCGCTCGGGCTCTGACTCTGACGTCG
GCACACACGGCCCCGGACGGCCAGAGGGGAACCGCCGGGTGACACCTGCGTGGAGGCTGAGCTGAGAAAGGGCCTCCGCTTAGAGCTGCG
GGTGAGGACGTCCTTTTCTAAGCAACACAGTCTTCCTCGGTCTGAGAGAAAAGCAGCCCACTCTTGTGTTCTCAGGCAGGGGATCTCCAA
ATGCAAAAGGAAGCTTGTAGAGGTTTTTTGGGTGAGAAGAAAAATGTAGCTAAGGTAATGGTTCATATCATACAAACAGCTCCCACGATC
CTGAAATTCTGTTAACGAATCCTTCTCTTTGGACATCTTCCCAAGAAACTTAGCCCTGAGTCCTAGGAGGAGCACCTCTGCACCAGCACG
GACCTCTCGCTCCACCCAGCTCTGTGCCCAAGGCCCCTGATCTCTGCTGAGGTGCCCACACCCACGTTCGATCACCCCTGCCATTCCCTT
TTATTTTCTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACCATCTTGGCTCACTTCAACCTCCGCCCCC
AAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCCGCCACCGTACCTGGCTAATTTTTGTATTTTTAG
TAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGA
TTACAGGCGTGAGCCGCCGTGCCCGGCCCCCTTTTCTTTTCAAAGCAGAACTACAAAGATGAGAAATTACCAGAAGCCTCGCCTTTTCCT
AAGCACCAGCGGAAGGAGCTGTGCCCCGGGATGGAGTGAGGGTGGAGGGCGCGTCAGCCACGGGTGGGCCTTGTGTCGCCTTGTATCGGC
CCAGGTAGGTTGTTGGCCTCTTACTTGGGCTGACCTGACCCCCGAAAGAGAAACAGACAACTCTGTTCTCAGGATTGGGGATGGACGGCT
TCGGCCAAGCGTTTTAGCCTCATTCACTCAGGCCCCACTCAGCACTCTGCCAGCCAAGACCATTGATTTGGAAAATCCGGTCCCCACCCG
CTAATGAGCTGTTGACACTGTTGTTCCTTGCTGAATTGGATTGTTGACTTGTAGTTCAGAGGCGTACAACTAGTTGGCGATTAGACTTGT
TATGTGATGTTACCAGCCTGAAATGCGATCACCCCGTAGGAAATAAAGCAGGCATCTCTGGACCTCATCCACCCTGGGCCTCTGCTGTCC

>98486_98486_4_VPS53-NXN_VPS53_chr17_613773_ENST00000571805_NXN_chr17_729318_ENST00000336868_length(amino acids)=371AA_BP=55
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVI
RDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFK
QYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVD
SEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEAFVND

--------------------------------------------------------------
>98486_98486_5_VPS53-NXN_VPS53_chr17_613773_ENST00000574029_NXN_chr17_729318_ENST00000336868_length(transcript)=2873nt_BP=289nt
GCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGGCCTGAGTTGGGCTCGC
GGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAGCCGTGCTGCAGCTCAC
GCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTGTTGAGTATATCAATAC
CCTGTTCCCAACCGAGCAACTCAAACTTTGGAACAAATACCGAATTTCCAACATTCCATCACTAATATTCCTCGACGCCACCACTGGGAA
GGTTGTGTGCAGGAACGGGCTGCTGGTGATCCGAGATGACCCAGAAGGTCTGGAGTTCCCCTGGGGACCGAAACCCTTCAGGGAAGTCAT
TGCAGGGCCCTTGCTTAGAAACAATGGGCAGTCTCTGGAGAGCAGCAGCCTGGAGGGGTCTCACGTGGGCGTCTATTTCTCCGCACATTG
GTGTCCGCCCTGCCGAAGCCTCACCCGGGTCCTGGTGGAATCCTACCGGAAGATCAAGGAGGCAGGCCAGAACTTCGAGATCATCTTCGT
TAGTGCAGACAGGTCGGAGGAGTCCTTCAAACAGTACTTCAGTGAGATGCCCTGGCTCGCCGTCCCCTACACGGATGAGGCCCGGCGGTC
GCGCCTCAACCGGCTGTACGGAATCCAAGGCATCCCCACGCTCATCATGCTGGACCCGCAGGGCGAGGTGATCACGCGGCAGGGGCGGGT
GGAGGTGCTGAACGACGAGGACTGCCGGGAGTTCCCCTGGCACCCCAAGCCCGTGCTGGAGCTCTCCGACTCCAACGCCGCGCAGCTTAA
CGAGGGCCCCTGCCTCGTCCTTTTTGTAGATTCTGAGGATGACGGAGAGTCCGAGGCGGCCAAGCAGCTGATTCAGCCGATAGCTGAGAA
AATCATTGCCAAGTACAAAGCCAAAGAGGAGGAGGCACCCCTTCTGTTCTTCGTAGCCGGGGAGGATGACATGACTGACTCCCTGCGAGA
TTACACCAACCTGCCTGAGGCTGCCCCTTTGCTCACCATCCTGGACATGTCAGCCCGGGCCAAGTACGTGATGGACGTGGAGGAGATCAC
CCCCGCCATCGTGGAGGCCTTTGTGAATGACTTCCTAGCAGAGAAGCTCAAACCGGAGCCCATCTAGCGTGGCTCCGGCCTCCTGAGACG
TTATTTAAAACTCAGCCTTCTCCTCCTCCCCCTCCTTCCTTCCGCCCTTGGACTTACCCAGCGTGCCCCGAATCCCACCACCCAAGTGTC
CAGCCTCTCTGTGGTGCCTTGTTTCTGCAGTAAACTCCTCAGCCAGCACCCTGGGGTGTGGAATCAGCAGCGGCAGAGTCCACCGTGTTT
GGAGACTCTGTTTGGGAGCACGGGATGGCCGGGGGCCCGGCCAGAGCGGGGCTGCATGGCTTTCGCAAAGTCACTAGCTTTTGGTGAAGG
ATCTGCCAGGGTGTCCTGGGCAGAGTGAGCGTGGAGGGCCGGTGGGTCCCGCTCGGGCTCTGACTCTGACGTCGGCACACACGGCCCCGG
ACGGCCAGAGGGGAACCGCCGGGTGACACCTGCGTGGAGGCTGAGCTGAGAAAGGGCCTCCGCTTAGAGCTGCGGGTGAGGACGTCCTTT
TCTAAGCAACACAGTCTTCCTCGGTCTGAGAGAAAAGCAGCCCACTCTTGTGTTCTCAGGCAGGGGATCTCCAAATGCAAAAGGAAGCTT
GTAGAGGTTTTTTGGGTGAGAAGAAAAATGTAGCTAAGGTAATGGTTCATATCATACAAACAGCTCCCACGATCCTGAAATTCTGTTAAC
GAATCCTTCTCTTTGGACATCTTCCCAAGAAACTTAGCCCTGAGTCCTAGGAGGAGCACCTCTGCACCAGCACGGACCTCTCGCTCCACC
CAGCTCTGTGCCCAAGGCCCCTGATCTCTGCTGAGGTGCCCACACCCACGTTCGATCACCCCTGCCATTCCCTTTTATTTTCTTTTTTTT
GAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACCATCTTGGCTCACTTCAACCTCCGCCCCCAAGGTTCAAGTGATTC
TCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCCGCCACCGTACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCA
CCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCG
CCGTGCCCGGCCCCCTTTTCTTTTCAAAGCAGAACTACAAAGATGAGAAATTACCAGAAGCCTCGCCTTTTCCTAAGCACCAGCGGAAGG
AGCTGTGCCCCGGGATGGAGTGAGGGTGGAGGGCGCGTCAGCCACGGGTGGGCCTTGTGTCGCCTTGTATCGGCCCAGGTAGGTTGTTGG
CCTCTTACTTGGGCTGACCTGACCCCCGAAAGAGAAACAGACAACTCTGTTCTCAGGATTGGGGATGGACGGCTTCGGCCAAGCGTTTTA
GCCTCATTCACTCAGGCCCCACTCAGCACTCTGCCAGCCAAGACCATTGATTTGGAAAATCCGGTCCCCACCCGCTAATGAGCTGTTGAC
ACTGTTGTTCCTTGCTGAATTGGATTGTTGACTTGTAGTTCAGAGGCGTACAACTAGTTGGCGATTAGACTTGTTATGTGATGTTACCAG

>98486_98486_5_VPS53-NXN_VPS53_chr17_613773_ENST00000574029_NXN_chr17_729318_ENST00000336868_length(amino acids)=371AA_BP=55
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVI
RDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFK
QYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVD
SEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEAFVND

--------------------------------------------------------------

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Fusion Gene PPI Analysis for VPS53-NXN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VPS53-NXN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VPS53-NXN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource