FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:VPS53-UBR5 (FusionGDB2 ID:98493)

Fusion Gene Summary for VPS53-UBR5

check button Fusion gene summary
Fusion gene informationFusion gene name: VPS53-UBR5
Fusion gene ID: 98493
HgeneTgene
Gene symbol

VPS53

UBR5

Gene ID

55275

51366

Gene nameVPS53 subunit of GARP complexubiquitin protein ligase E3 component n-recognin 5
SynonymsHCCS1|PCH2E|hVps53L|pp13624DD5|EDD|EDD1|HYD
Cytomap

17p13.3

8q22.3

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 53 homologVPS53, GARP complex subunitE3 ubiquitin-protein ligase UBR5E3 identified by differential displayE3 ubiquitin-protein ligase, HECT domain-containing 1HECT-type E3 ubiquitin transferase UBR5hyperplastic discs protein homologprogestin-induced protein
Modification date2020031320200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000291074, ENST00000437048, 
ENST00000446250, ENST00000571805, 
ENST00000576149, ENST00000401468, 
ENST00000574029, 		ENST00000519528, 
ENST00000220959, ENST00000518205, 
ENST00000520539, ENST00000521922, 
Fusion gene scores* DoF score18 X 15 X 14=378014 X 17 X 10=2380
# samples 2419
** MAII scorelog2(24/3780*10)=-3.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2380*10)=-3.64689024986436
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VPS53 [Title/Abstract] AND UBR5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVPS53(526773)-UBR5(103277506), # samples:1
Anticipated loss of major functional domain due to fusion event.VPS53-UBR5 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
VPS53-UBR5 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
VPS53-UBR5 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
VPS53-UBR5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBR5

GO:0000209

protein polyubiquitination

21118991|28689657

TgeneUBR5

GO:0006974

cellular response to DNA damage stimulus

12011095

TgeneUBR5

GO:0010628

positive regulation of gene expression

18076571

TgeneUBR5

GO:0050847

progesterone receptor signaling pathway

12011095

TgeneUBR5

GO:0070936

protein K48-linked ubiquitination

28689657


check buttonFusion gene breakpoints across VPS53 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IN-8462-11AVPS53chr17

526773

-UBR5chr8

103277506

-


Top

Fusion Gene ORF analysis for VPS53-UBR5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000291074ENST00000519528VPS53chr17

526773

-UBR5chr8

103277506

-
5CDS-intronENST00000437048ENST00000519528VPS53chr17

526773

-UBR5chr8

103277506

-
5CDS-intronENST00000446250ENST00000519528VPS53chr17

526773

-UBR5chr8

103277506

-
5CDS-intronENST00000571805ENST00000519528VPS53chr17

526773

-UBR5chr8

103277506

-
5UTR-3CDSENST00000576149ENST00000220959VPS53chr17

526773

-UBR5chr8

103277506

-
5UTR-3CDSENST00000576149ENST00000518205VPS53chr17

526773

-UBR5chr8

103277506

-
5UTR-3CDSENST00000576149ENST00000520539VPS53chr17

526773

-UBR5chr8

103277506

-
5UTR-3CDSENST00000576149ENST00000521922VPS53chr17

526773

-UBR5chr8

103277506

-
5UTR-intronENST00000576149ENST00000519528VPS53chr17

526773

-UBR5chr8

103277506

-
Frame-shiftENST00000446250ENST00000220959VPS53chr17

526773

-UBR5chr8

103277506

-
Frame-shiftENST00000446250ENST00000518205VPS53chr17

526773

-UBR5chr8

103277506

-
Frame-shiftENST00000446250ENST00000520539VPS53chr17

526773

-UBR5chr8

103277506

-
Frame-shiftENST00000446250ENST00000521922VPS53chr17

526773

-UBR5chr8

103277506

-
In-frameENST00000291074ENST00000220959VPS53chr17

526773

-UBR5chr8

103277506

-
In-frameENST00000291074ENST00000518205VPS53chr17

526773

-UBR5chr8

103277506

-
In-frameENST00000291074ENST00000520539VPS53chr17

526773

-UBR5chr8

103277506

-
In-frameENST00000291074ENST00000521922VPS53chr17

526773

-UBR5chr8

103277506

-
In-frameENST00000437048ENST00000220959VPS53chr17

526773

-UBR5chr8

103277506

-
In-frameENST00000437048ENST00000518205VPS53chr17

526773

-UBR5chr8

103277506

-
In-frameENST00000437048ENST00000520539VPS53chr17

526773

-UBR5chr8

103277506

-
In-frameENST00000437048ENST00000521922VPS53chr17

526773

-UBR5chr8

103277506

-
In-frameENST00000571805ENST00000220959VPS53chr17

526773

-UBR5chr8

103277506

-
In-frameENST00000571805ENST00000518205VPS53chr17

526773

-UBR5chr8

103277506

-
In-frameENST00000571805ENST00000520539VPS53chr17

526773

-UBR5chr8

103277506

-
In-frameENST00000571805ENST00000521922VPS53chr17

526773

-UBR5chr8

103277506

-
intron-3CDSENST00000401468ENST00000220959VPS53chr17

526773

-UBR5chr8

103277506

-
intron-3CDSENST00000401468ENST00000518205VPS53chr17

526773

-UBR5chr8

103277506

-
intron-3CDSENST00000401468ENST00000520539VPS53chr17

526773

-UBR5chr8

103277506

-
intron-3CDSENST00000401468ENST00000521922VPS53chr17

526773

-UBR5chr8

103277506

-
intron-3CDSENST00000574029ENST00000220959VPS53chr17

526773

-UBR5chr8

103277506

-
intron-3CDSENST00000574029ENST00000518205VPS53chr17

526773

-UBR5chr8

103277506

-
intron-3CDSENST00000574029ENST00000520539VPS53chr17

526773

-UBR5chr8

103277506

-
intron-3CDSENST00000574029ENST00000521922VPS53chr17

526773

-UBR5chr8

103277506

-
intron-intronENST00000401468ENST00000519528VPS53chr17

526773

-UBR5chr8

103277506

-
intron-intronENST00000574029ENST00000519528VPS53chr17

526773

-UBR5chr8

103277506

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000437048VPS53chr17526773-ENST00000520539UBR5chr8103277506-353112631472240697
ENST00000437048VPS53chr17526773-ENST00000220959UBR5chr8103277506-280412631472237696
ENST00000437048VPS53chr17526773-ENST00000518205UBR5chr8103277506-234212631472237696
ENST00000437048VPS53chr17526773-ENST00000521922UBR5chr8103277506-234212631472237696
ENST00000291074VPS53chr17526773-ENST00000520539UBR5chr8103277506-343111631342140668
ENST00000291074VPS53chr17526773-ENST00000220959UBR5chr8103277506-270411631342137667
ENST00000291074VPS53chr17526773-ENST00000518205UBR5chr8103277506-224211631342137667
ENST00000291074VPS53chr17526773-ENST00000521922UBR5chr8103277506-224211631342137667
ENST00000571805VPS53chr17526773-ENST00000520539UBR5chr8103277506-352112531372230697
ENST00000571805VPS53chr17526773-ENST00000220959UBR5chr8103277506-279412531372227696
ENST00000571805VPS53chr17526773-ENST00000518205UBR5chr8103277506-233212531372227696
ENST00000571805VPS53chr17526773-ENST00000521922UBR5chr8103277506-233212531372227696

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000437048ENST00000520539VPS53chr17526773-UBR5chr8103277506-0.0007346650.9992654
ENST00000437048ENST00000220959VPS53chr17526773-UBR5chr8103277506-0.0019989370.99800104
ENST00000437048ENST00000518205VPS53chr17526773-UBR5chr8103277506-0.0038310130.99616903
ENST00000437048ENST00000521922VPS53chr17526773-UBR5chr8103277506-0.0038310130.99616903
ENST00000291074ENST00000520539VPS53chr17526773-UBR5chr8103277506-0.0003947750.99960524
ENST00000291074ENST00000220959VPS53chr17526773-UBR5chr8103277506-0.0012792830.9987207
ENST00000291074ENST00000518205VPS53chr17526773-UBR5chr8103277506-0.0025981060.99740195
ENST00000291074ENST00000521922VPS53chr17526773-UBR5chr8103277506-0.0025981060.99740195
ENST00000571805ENST00000520539VPS53chr17526773-UBR5chr8103277506-0.0007321530.9992679
ENST00000571805ENST00000220959VPS53chr17526773-UBR5chr8103277506-0.0019754240.9980246
ENST00000571805ENST00000518205VPS53chr17526773-UBR5chr8103277506-0.0037827560.9962172
ENST00000571805ENST00000521922VPS53chr17526773-UBR5chr8103277506-0.0037827560.9962172

Top

Fusion Genomic Features for VPS53-UBR5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for VPS53-UBR5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:526773/chr8:103277506)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVPS53chr17:526773chr8:103277506ENST00000291074-101897_138343671.0Coiled coilOntology_term=ECO:0000255
HgeneVPS53chr17:526773chr8:103277506ENST00000437048-112297_138372833.0Coiled coilOntology_term=ECO:0000255
HgeneVPS53chr17:526773chr8:103277506ENST00000571805-111997_138372700.0Coiled coilOntology_term=ECO:0000255
TgeneUBR5chr17:526773chr8:103277506ENST0000052053951592489_250024742800.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneUBR5chr17:526773chr8:103277506ENST0000052053951592737_275724742800.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUBR5chr17:526773chr8:103277506ENST0000052053951591528_153724742800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr17:526773chr8:103277506ENST0000052053951591671_168124742800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr17:526773chr8:103277506ENST0000052053951591762_176824742800.0Compositional biasNote=Poly-Ala
TgeneUBR5chr17:526773chr8:103277506ENST0000052053951591986_199724742800.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneUBR5chr17:526773chr8:103277506ENST0000052053951592036_205924742800.0Compositional biasNote=Pro-rich
TgeneUBR5chr17:526773chr8:103277506ENST0000052053951592329_234824742800.0Compositional biasNote=Arg/Glu-rich (mixed charge)
TgeneUBR5chr17:526773chr8:103277506ENST0000052053951592357_236624742800.0Compositional biasNote=Arg/Asp-rich (mixed charge)
TgeneUBR5chr17:526773chr8:103277506ENST000005205395159940_94524742800.0Compositional biasNote=Poly-Glu
TgeneUBR5chr17:526773chr8:103277506ENST000005205395159980_98524742800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr17:526773chr8:103277506ENST0000052053951592377_245424742800.0DomainPABC
TgeneUBR5chr17:526773chr8:103277506ENST0000052053951592462_279924742800.0DomainHECT
TgeneUBR5chr17:526773chr8:103277506ENST0000052053951591177_124524742800.0Zinc fingerUBR-type


Top

Fusion Gene Sequence for VPS53-UBR5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98493_98493_1_VPS53-UBR5_VPS53_chr17_526773_ENST00000291074_UBR5_chr8_103277506_ENST00000220959_length(transcript)=2704nt_BP=1163nt
GGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGGCCT
GAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAGCCG
TGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTGTTG
AGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGACTGG
ATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGTGAAAGAAATCACCCGTGATATTAAGCAAT
TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA
TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC
CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT
CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG
AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG
ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA
GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC
TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGGAAAACC
GAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAAC
CTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGAC
TATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATT
TTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAA
TGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTC
CACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTC
TACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGC
AAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAG
TAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGC
CTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATT
CCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCT
GTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCTGGTGGTA
CCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTATATTGGTTTGC
TAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGCTGAGGGGGAA
AAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGGAATTTCAAAA
TAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATCATGTATATGG
AACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTTTGACTGCATT

>98493_98493_1_VPS53-UBR5_VPS53_chr17_526773_ENST00000291074_UBR5_chr8_103277506_ENST00000220959_length(amino acids)=667AA_BP=343
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQT
ELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYE
EKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLENRKRHGSSRSVVDMDL
DDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL
ILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTA
EDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHL

--------------------------------------------------------------
>98493_98493_2_VPS53-UBR5_VPS53_chr17_526773_ENST00000291074_UBR5_chr8_103277506_ENST00000518205_length(transcript)=2242nt_BP=1163nt
GGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGGCCT
GAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAGCCG
TGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTGTTG
AGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGACTGG
ATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGTGAAAGAAATCACCCGTGATATTAAGCAAT
TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA
TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC
CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT
CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG
AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG
ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA
GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC
TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGGAAAACC
GAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAAC
CTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGAC
TATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATT
TTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAA
TGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTC
CACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTC
TACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGC
AAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAG
TAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGC
CTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATT
CCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCT

>98493_98493_2_VPS53-UBR5_VPS53_chr17_526773_ENST00000291074_UBR5_chr8_103277506_ENST00000518205_length(amino acids)=667AA_BP=343
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQT
ELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYE
EKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLENRKRHGSSRSVVDMDL
DDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL
ILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTA
EDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHL

--------------------------------------------------------------
>98493_98493_3_VPS53-UBR5_VPS53_chr17_526773_ENST00000291074_UBR5_chr8_103277506_ENST00000520539_length(transcript)=3431nt_BP=1163nt
GGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGGCCT
GAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAGCCG
TGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTGTTG
AGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGACTGG
ATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGTGAAAGAAATCACCCGTGATATTAAGCAAT
TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA
TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC
CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT
CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG
AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG
ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA
GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC
TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGCAGGAAA
ACCGAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACC
AACCTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTG
GACTATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATG
ATTTTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAG
CAATGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCA
CTCCACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAG
GTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATG
TGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAA
TAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCC
AGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCT
ATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATT
GCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCTGGTG
GTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTATATTGGTT
TGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGCTGAGGGG
GAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGGAATTTCA
AAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATCATGTATA
TGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTTTGACTGC
ATTGAGCTCTAGGATATTAAATGATATCACTAATATTTTGCATGTAATTTGCTCATTTGAGTGAGGGCACTTTTTTTGTACATATGATGG
GGCCAATGCACAATACTTTTATCACAATCAACTTTTTCTTTGTATCCCTATTTCAATGAGCAGTCAGTCTCAAGAGGTTACTGCACTTCA
GTTCTAACTAGACATTTGTACTAAGGTATTTCAGTTATGTAAACTCAGCCTGGGCACTTTCTGATAACTGTAAAATGTTTTATAAGATCA
TGATTATTGAAGATACATTTTGGAAAATTTTAAATGTTCGTGAGCAGCTTAACTACTTTTGTATCTAGCCTTTTTTAAGTATCTTGTTAC
ATTTACTTTTTTAAATAAAGAAATTACAGAAGAAATGTCAAGTAATATTGAAGAAACAATAGTTTTTATTTATGTAGTTGTACATTTTTA
AACTAAGGGCAATACACTGACATGGTTATGTGCATAAAAATTTTGACTTAAAGAACTGGAAGTTTATATACACCTGGACTATAAGAAACA
GAAGAAAATCAGTCCACATTTTACAGTTAGCAGAGAATCCTAAATGGCACTGGCCTGGCCACCTTTTCATTTTACAAATGGGGGAAGTGA
AGTGTGACCCCTTACTTGGCATAGGAAGTTAACTTACACCTAATAACTGACAGGTTTTTGTTTTGATGACCTATTAATTATGTAGCCTAG

>98493_98493_3_VPS53-UBR5_VPS53_chr17_526773_ENST00000291074_UBR5_chr8_103277506_ENST00000520539_length(amino acids)=668AA_BP=343
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQT
ELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYE
EKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLQENRKRHGSSRSVVDMD
LDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQ
LILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLT
AEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQH

--------------------------------------------------------------
>98493_98493_4_VPS53-UBR5_VPS53_chr17_526773_ENST00000291074_UBR5_chr8_103277506_ENST00000521922_length(transcript)=2242nt_BP=1163nt
GGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGGCCT
GAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAGCCG
TGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTGTTG
AGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGACTGG
ATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGTGAAAGAAATCACCCGTGATATTAAGCAAT
TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA
TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC
CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT
CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG
AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG
ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA
GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC
TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGGAAAACC
GAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAAC
CTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGAC
TATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATT
TTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAA
TGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTC
CACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTC
TACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGC
AAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAG
TAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGC
CTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATT
CCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCT

>98493_98493_4_VPS53-UBR5_VPS53_chr17_526773_ENST00000291074_UBR5_chr8_103277506_ENST00000521922_length(amino acids)=667AA_BP=343
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQT
ELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYE
EKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLENRKRHGSSRSVVDMDL
DDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL
ILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTA
EDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHL

--------------------------------------------------------------
>98493_98493_5_VPS53-UBR5_VPS53_chr17_526773_ENST00000437048_UBR5_chr8_103277506_ENST00000220959_length(transcript)=2804nt_BP=1263nt
GAAGTGCCGGAGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGG
CGGCTGGAGGCCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAG
GAGCTGGAAGCCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGAT
TTCAATGCTGTTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAA
ATAAGGAGACTGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAG
AAAGCTATCCAACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGAT
ATTAAGCAATTAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCC
CTCGAAGCCATGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTAT
ATGGGGATTCCGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAA
GCGTTTCCTTCCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGG
ATCAAACAGGAAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTG
GACAAAATCGACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGC
ATGGCTGAGAGGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTG
AAATTGCTTCTTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACC
CTGGAAAACCGAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTG
TTTTACCAACCTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGG
ATTCTTGGACTATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAAT
TGGCATGATTTTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTT
TTCTCAGCAATGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATA
CCAGTCACTCCACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATG
AGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAA
GTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTC
TGGTCAATAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAA
GGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTC
CCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGT
GTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCC
CCTGGTGGTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTAT
ATTGGTTTGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGC
TGAGGGGGAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGG
AATTTCAAAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATC
ATGTATATGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTT

>98493_98493_5_VPS53-UBR5_VPS53_chr17_526773_ENST00000437048_UBR5_chr8_103277506_ENST00000220959_length(amino acids)=696AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH
VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM
LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW

--------------------------------------------------------------
>98493_98493_6_VPS53-UBR5_VPS53_chr17_526773_ENST00000437048_UBR5_chr8_103277506_ENST00000518205_length(transcript)=2342nt_BP=1263nt
GAAGTGCCGGAGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGG
CGGCTGGAGGCCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAG
GAGCTGGAAGCCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGAT
TTCAATGCTGTTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAA
ATAAGGAGACTGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAG
AAAGCTATCCAACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGAT
ATTAAGCAATTAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCC
CTCGAAGCCATGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTAT
ATGGGGATTCCGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAA
GCGTTTCCTTCCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGG
ATCAAACAGGAAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTG
GACAAAATCGACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGC
ATGGCTGAGAGGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTG
AAATTGCTTCTTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACC
CTGGAAAACCGAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTG
TTTTACCAACCTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGG
ATTCTTGGACTATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAAT
TGGCATGATTTTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTT
TTCTCAGCAATGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATA
CCAGTCACTCCACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATG
AGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAA
GTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTC
TGGTCAATAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAA
GGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTC
CCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGT
GTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCC

>98493_98493_6_VPS53-UBR5_VPS53_chr17_526773_ENST00000437048_UBR5_chr8_103277506_ENST00000518205_length(amino acids)=696AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH
VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM
LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW

--------------------------------------------------------------
>98493_98493_7_VPS53-UBR5_VPS53_chr17_526773_ENST00000437048_UBR5_chr8_103277506_ENST00000520539_length(transcript)=3531nt_BP=1263nt
GAAGTGCCGGAGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGG
CGGCTGGAGGCCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAG
GAGCTGGAAGCCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGAT
TTCAATGCTGTTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAA
ATAAGGAGACTGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAG
AAAGCTATCCAACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGAT
ATTAAGCAATTAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCC
CTCGAAGCCATGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTAT
ATGGGGATTCCGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAA
GCGTTTCCTTCCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGG
ATCAAACAGGAAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTG
GACAAAATCGACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGC
ATGGCTGAGAGGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTG
AAATTGCTTCTTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACC
CTGCAGGAAAACCGAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCT
TTGTTTTACCAACCTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGC
AGGATTCTTGGACTATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTC
AATTGGCATGATTTTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCT
GTTTTCTCAGCAATGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAAT
ATACCAGTCACTCCACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCA
ATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGT
GAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGG
TTCTGGTCAATAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAA
GAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTAC
GTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAA
AGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATAC
CCCCCTGGTGGTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGC
TATATTGGTTTGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTT
TGCTGAGGGGGAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATA
GGGAATTTCAAAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGT
ATCATGTATATGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCG
GTTTGACTGCATTGAGCTCTAGGATATTAAATGATATCACTAATATTTTGCATGTAATTTGCTCATTTGAGTGAGGGCACTTTTTTTGTA
CATATGATGGGGCCAATGCACAATACTTTTATCACAATCAACTTTTTCTTTGTATCCCTATTTCAATGAGCAGTCAGTCTCAAGAGGTTA
CTGCACTTCAGTTCTAACTAGACATTTGTACTAAGGTATTTCAGTTATGTAAACTCAGCCTGGGCACTTTCTGATAACTGTAAAATGTTT
TATAAGATCATGATTATTGAAGATACATTTTGGAAAATTTTAAATGTTCGTGAGCAGCTTAACTACTTTTGTATCTAGCCTTTTTTAAGT
ATCTTGTTACATTTACTTTTTTAAATAAAGAAATTACAGAAGAAATGTCAAGTAATATTGAAGAAACAATAGTTTTTATTTATGTAGTTG
TACATTTTTAAACTAAGGGCAATACACTGACATGGTTATGTGCATAAAAATTTTGACTTAAAGAACTGGAAGTTTATATACACCTGGACT
ATAAGAAACAGAAGAAAATCAGTCCACATTTTACAGTTAGCAGAGAATCCTAAATGGCACTGGCCTGGCCACCTTTTCATTTTACAAATG
GGGGAAGTGAAGTGTGACCCCTTACTTGGCATAGGAAGTTAACTTACACCTAATAACTGACAGGTTTTTGTTTTGATGACCTATTAATTA

>98493_98493_7_VPS53-UBR5_VPS53_chr17_526773_ENST00000437048_UBR5_chr8_103277506_ENST00000520539_length(amino acids)=697AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNR
HVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHR
MLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYF

--------------------------------------------------------------
>98493_98493_8_VPS53-UBR5_VPS53_chr17_526773_ENST00000437048_UBR5_chr8_103277506_ENST00000521922_length(transcript)=2342nt_BP=1263nt
GAAGTGCCGGAGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGG
CGGCTGGAGGCCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAG
GAGCTGGAAGCCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGAT
TTCAATGCTGTTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAA
ATAAGGAGACTGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAG
AAAGCTATCCAACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGAT
ATTAAGCAATTAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCC
CTCGAAGCCATGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTAT
ATGGGGATTCCGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAA
GCGTTTCCTTCCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGG
ATCAAACAGGAAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTG
GACAAAATCGACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGC
ATGGCTGAGAGGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTG
AAATTGCTTCTTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACC
CTGGAAAACCGAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTG
TTTTACCAACCTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGG
ATTCTTGGACTATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAAT
TGGCATGATTTTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTT
TTCTCAGCAATGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATA
CCAGTCACTCCACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATG
AGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAA
GTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTC
TGGTCAATAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAA
GGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTC
CCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGT
GTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCC

>98493_98493_8_VPS53-UBR5_VPS53_chr17_526773_ENST00000437048_UBR5_chr8_103277506_ENST00000521922_length(amino acids)=696AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH
VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM
LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW

--------------------------------------------------------------
>98493_98493_9_VPS53-UBR5_VPS53_chr17_526773_ENST00000571805_UBR5_chr8_103277506_ENST00000220959_length(transcript)=2794nt_BP=1253nt
AGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGG
CCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAG
CCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTG
TTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGAC
TGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAGAAAGCTATCC
AACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGATATTAAGCAAT
TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA
TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC
CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT
CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG
AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG
ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA
GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC
TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGGAAAACC
GAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAAC
CTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGAC
TATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATT
TTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAA
TGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTC
CACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTC
TACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGC
AAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAG
TAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGC
CTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATT
CCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCT
GTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCTGGTGGTA
CCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTATATTGGTTTGC
TAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGCTGAGGGGGAA
AAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGGAATTTCAAAA
TAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATCATGTATATGG
AACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTTTGACTGCATT

>98493_98493_9_VPS53-UBR5_VPS53_chr17_526773_ENST00000571805_UBR5_chr8_103277506_ENST00000220959_length(amino acids)=696AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH
VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM
LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW

--------------------------------------------------------------
>98493_98493_10_VPS53-UBR5_VPS53_chr17_526773_ENST00000571805_UBR5_chr8_103277506_ENST00000518205_length(transcript)=2332nt_BP=1253nt
AGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGG
CCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAG
CCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTG
TTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGAC
TGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAGAAAGCTATCC
AACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGATATTAAGCAAT
TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA
TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC
CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT
CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG
AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG
ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA
GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC
TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGGAAAACC
GAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAAC
CTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGAC
TATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATT
TTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAA
TGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTC
CACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTC
TACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGC
AAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAG
TAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGC
CTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATT
CCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCT

>98493_98493_10_VPS53-UBR5_VPS53_chr17_526773_ENST00000571805_UBR5_chr8_103277506_ENST00000518205_length(amino acids)=696AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH
VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM
LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW

--------------------------------------------------------------
>98493_98493_11_VPS53-UBR5_VPS53_chr17_526773_ENST00000571805_UBR5_chr8_103277506_ENST00000520539_length(transcript)=3521nt_BP=1253nt
AGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGG
CCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAG
CCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTG
TTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGAC
TGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAGAAAGCTATCC
AACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGATATTAAGCAAT
TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA
TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC
CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT
CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG
AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG
ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA
GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC
TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGCAGGAAA
ACCGAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACC
AACCTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTG
GACTATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATG
ATTTTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAG
CAATGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCA
CTCCACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAG
GTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATG
TGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAA
TAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCC
AGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCT
ATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATT
GCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCTGGTG
GTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTATATTGGTT
TGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGCTGAGGGG
GAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGGAATTTCA
AAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATCATGTATA
TGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTTTGACTGC
ATTGAGCTCTAGGATATTAAATGATATCACTAATATTTTGCATGTAATTTGCTCATTTGAGTGAGGGCACTTTTTTTGTACATATGATGG
GGCCAATGCACAATACTTTTATCACAATCAACTTTTTCTTTGTATCCCTATTTCAATGAGCAGTCAGTCTCAAGAGGTTACTGCACTTCA
GTTCTAACTAGACATTTGTACTAAGGTATTTCAGTTATGTAAACTCAGCCTGGGCACTTTCTGATAACTGTAAAATGTTTTATAAGATCA
TGATTATTGAAGATACATTTTGGAAAATTTTAAATGTTCGTGAGCAGCTTAACTACTTTTGTATCTAGCCTTTTTTAAGTATCTTGTTAC
ATTTACTTTTTTAAATAAAGAAATTACAGAAGAAATGTCAAGTAATATTGAAGAAACAATAGTTTTTATTTATGTAGTTGTACATTTTTA
AACTAAGGGCAATACACTGACATGGTTATGTGCATAAAAATTTTGACTTAAAGAACTGGAAGTTTATATACACCTGGACTATAAGAAACA
GAAGAAAATCAGTCCACATTTTACAGTTAGCAGAGAATCCTAAATGGCACTGGCCTGGCCACCTTTTCATTTTACAAATGGGGGAAGTGA
AGTGTGACCCCTTACTTGGCATAGGAAGTTAACTTACACCTAATAACTGACAGGTTTTTGTTTTGATGACCTATTAATTATGTAGCCTAG

>98493_98493_11_VPS53-UBR5_VPS53_chr17_526773_ENST00000571805_UBR5_chr8_103277506_ENST00000520539_length(amino acids)=697AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNR
HVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHR
MLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYF

--------------------------------------------------------------
>98493_98493_12_VPS53-UBR5_VPS53_chr17_526773_ENST00000571805_UBR5_chr8_103277506_ENST00000521922_length(transcript)=2332nt_BP=1253nt
AGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGG
CCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAG
CCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTG
TTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGAC
TGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAGAAAGCTATCC
AACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGATATTAAGCAAT
TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA
TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC
CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT
CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG
AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG
ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA
GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC
TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGGAAAACC
GAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAAC
CTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGAC
TATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATT
TTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAA
TGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTC
CACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTC
TACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGC
AAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAG
TAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGC
CTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATT
CCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCT

>98493_98493_12_VPS53-UBR5_VPS53_chr17_526773_ENST00000571805_UBR5_chr8_103277506_ENST00000521922_length(amino acids)=696AA_BP=372
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG
QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG
VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV
LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK
RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH
VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM
LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for VPS53-UBR5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for VPS53-UBR5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for VPS53-UBR5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource