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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VPS72-ROBO2 (FusionGDB2 ID:98505)

Fusion Gene Summary for VPS72-ROBO2

check button Fusion gene summary
Fusion gene informationFusion gene name: VPS72-ROBO2
Fusion gene ID: 98505
HgeneTgene
Gene symbol

VPS72

ROBO2

Gene ID

6944

6092

Gene namevacuolar protein sorting 72 homologroundabout guidance receptor 2
SynonymsCFL1|Swc2|TCFL1|YL-1|YL1SAX3
Cytomap

1q21.3

3p12.3

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 72 homologtranscription factor-like 1transformation suppressor gene YL-1roundabout homolog 2roundabout, axon guidance receptor, homolog 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000354473, ENST00000496809, 
ENST00000469233, ENST00000332191, 
ENST00000461745, ENST00000487694, 
Fusion gene scores* DoF score9 X 8 X 5=36018 X 21 X 7=2646
# samples 922
** MAII scorelog2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2646*10)=-3.58823763275402
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VPS72 [Title/Abstract] AND ROBO2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVPS72(151156793)-ROBO2(77617464), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneROBO2

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

12504588

TgeneROBO2

GO:0050772

positive regulation of axonogenesis

12504588

TgeneROBO2

GO:0050925

negative regulation of negative chemotaxis

11748139


check buttonFusion gene breakpoints across VPS72 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ROBO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-91-A4BC-01AVPS72chr1

151156793

-ROBO2chr3

77617464

+


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Fusion Gene ORF analysis for VPS72-ROBO2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000354473ENST00000469233VPS72chr1

151156793

-ROBO2chr3

77617464

+
5UTR-3CDSENST00000496809ENST00000332191VPS72chr1

151156793

-ROBO2chr3

77617464

+
5UTR-3CDSENST00000496809ENST00000461745VPS72chr1

151156793

-ROBO2chr3

77617464

+
5UTR-3CDSENST00000496809ENST00000487694VPS72chr1

151156793

-ROBO2chr3

77617464

+
5UTR-intronENST00000496809ENST00000469233VPS72chr1

151156793

-ROBO2chr3

77617464

+
In-frameENST00000354473ENST00000332191VPS72chr1

151156793

-ROBO2chr3

77617464

+
In-frameENST00000354473ENST00000461745VPS72chr1

151156793

-ROBO2chr3

77617464

+
In-frameENST00000354473ENST00000487694VPS72chr1

151156793

-ROBO2chr3

77617464

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354473VPS72chr1151156793-ENST00000487694ROBO2chr377617464+4342599372886949
ENST00000354473VPS72chr1151156793-ENST00000461745ROBO2chr377617464+6796599372886949
ENST00000354473VPS72chr1151156793-ENST00000332191ROBO2chr377617464+41315993730691010

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354473ENST00000487694VPS72chr1151156793-ROBO2chr377617464+0.0001602940.99983966
ENST00000354473ENST00000461745VPS72chr1151156793-ROBO2chr377617464+7.64E-050.9999236
ENST00000354473ENST00000332191VPS72chr1151156793-ROBO2chr377617464+0.0001685220.99983144

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Fusion Genomic Features for VPS72-ROBO2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
VPS72chr1151156792-ROBO2chr377617463+2.65E-050.99997354
VPS72chr1151156792-ROBO2chr377617463+2.65E-050.99997354

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for VPS72-ROBO2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:151156793/chr3:77617464)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVPS72chr1:151156793chr3:77617464ENST00000354473-4622_77187376.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneROBO2chr1:151156793chr3:77617464ENST000004617451126637_7356161379.0DomainFibronectin type-III 2
TgeneROBO2chr1:151156793chr3:77617464ENST000004617451126739_8366161379.0DomainFibronectin type-III 3
TgeneROBO2chr1:151156793chr3:77617464ENST000004876941227637_7356321395.0DomainFibronectin type-III 2
TgeneROBO2chr1:151156793chr3:77617464ENST000004876941227739_8366321395.0DomainFibronectin type-III 3
TgeneROBO2chr1:151156793chr3:77617464ENST000004617451126881_13786161379.0Topological domainCytoplasmic
TgeneROBO2chr1:151156793chr3:77617464ENST000004876941227881_13786321395.0Topological domainCytoplasmic
TgeneROBO2chr1:151156793chr3:77617464ENST000004617451126860_8806161379.0TransmembraneHelical
TgeneROBO2chr1:151156793chr3:77617464ENST000004876941227860_8806321395.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVPS72chr1:151156793chr3:77617464ENST00000354473-46333_354187376.0Compositional biasNote=Pro-rich
HgeneVPS72chr1:151156793chr3:77617464ENST00000354473-46341_350187376.0Compositional biasNote=Poly-Pro
HgeneVPS72chr1:151156793chr3:77617464ENST00000354473-46156_206187376.0DNA bindingOntology_term=ECO:0000255
TgeneROBO2chr1:151156793chr3:77617464ENST000004617451126133_2206161379.0DomainNote=Ig-like C2-type 2
TgeneROBO2chr1:151156793chr3:77617464ENST000004617451126225_3096161379.0DomainNote=Ig-like C2-type 3
TgeneROBO2chr1:151156793chr3:77617464ENST000004617451126314_4096161379.0DomainNote=Ig-like C2-type 4
TgeneROBO2chr1:151156793chr3:77617464ENST00000461745112631_1276161379.0DomainNote=Ig-like C2-type 1
TgeneROBO2chr1:151156793chr3:77617464ENST000004617451126418_5046161379.0DomainNote=Ig-like C2-type 5
TgeneROBO2chr1:151156793chr3:77617464ENST000004617451126524_6186161379.0DomainFibronectin type-III 1
TgeneROBO2chr1:151156793chr3:77617464ENST000004876941227133_2206321395.0DomainNote=Ig-like C2-type 2
TgeneROBO2chr1:151156793chr3:77617464ENST000004876941227225_3096321395.0DomainNote=Ig-like C2-type 3
TgeneROBO2chr1:151156793chr3:77617464ENST000004876941227314_4096321395.0DomainNote=Ig-like C2-type 4
TgeneROBO2chr1:151156793chr3:77617464ENST00000487694122731_1276321395.0DomainNote=Ig-like C2-type 1
TgeneROBO2chr1:151156793chr3:77617464ENST000004876941227418_5046321395.0DomainNote=Ig-like C2-type 5
TgeneROBO2chr1:151156793chr3:77617464ENST000004876941227524_6186321395.0DomainFibronectin type-III 1
TgeneROBO2chr1:151156793chr3:77617464ENST00000461745112622_8596161379.0Topological domainExtracellular
TgeneROBO2chr1:151156793chr3:77617464ENST00000487694122722_8596321395.0Topological domainExtracellular


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Fusion Gene Sequence for VPS72-ROBO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98505_98505_1_VPS72-ROBO2_VPS72_chr1_151156793_ENST00000354473_ROBO2_chr3_77617464_ENST00000332191_length(transcript)=4131nt_BP=599nt
AGGGGCTGCAGGTGGCGGCGCAGTCTCGGTAGGCGGTATGAGTTTGGCTGGGGGCCGGGCACCCCGGAAGACCGCTGGGAACCGGCTTTC
TGGGCTTTTGGAGGCAGAGGAGGAAGATGAGTTCTACCAGACGACTTATGGGGGTTTCACAGAGGAATCCGGAGATGATGAGTATCAAGG
GGACCAGTCAGACACAGAGGACGAAGTGGACTCTGACTTTGACATTGATGAAGGGGATGAACCATCCAGTGATGGAGAAGCAGAAGAGCC
AAGAAGGAAGCGCCGAGTAGTCACCAAGGCCTATAAGGAACCTCTCAAGAGCTTAAGGCCTCGAAAGGTCAACACCCCGGCTGGTAGCTC
TCAGAAGGCGCGAGAAGAGAAGGCACTACTGCCATTAGAACTACAAGATGACGGCTCTGACAGTCGGAAGTCTATGCGTCAGTCTACAGC
TGAGCATACACGACAAACGTTCCTTCGGGTACAGGAGAGGCAGGGCCAGTCAAGACGGCGAAAGGGGCCCCACTGTGAGCGGCCACTAAC
CCAGGAGGAACTGCTCCGGGAGGCCAAGATCACAGAAGAGCTTAATTTACGGTCACTGGATATCAGCCCACCAGCACAAGGAGTGGACCA
CAGGCAAGTGCAGAAAGAGCTAGGAGATGTCCTTGTCCGTCTTCATAATCCAGTTGTGCTGACTCCCACCACGGTTCAGGTCACATGGAC
GGTTGATCGCCAACCCCAGTTTATCCAAGGCTACCGAGTGATGTATCGTCAGACTTCAGGTCTGCAGGCGACATCTTCGTGGCAGAATTT
AGATGCCAAAGTCCCGACTGAACGAAGTGCTGTCTTAGTCAACCTGAAAAAGGGGGTGACTTATGAAATTAAAGTACGGCCATATTTTAA
TGAGTTCCAAGGAATGGATAGTGAATCTAAAACGGTTCGTACTACTGAAGAAGCCCCAAGTGCCCCACCACAGTCTGTCACTGTACTGAC
AGTTGGAAGCTACAATAGCACAAGTATTAGTGTTTCCTGGGATCCTCCTCCTCCAGATCACCAGAATGGAATTATCCAAGAATACAAGAT
CTGGTGTCTAGGAAATGAAACGCGATTCCATATCAACAAAACTGTGGATGCAGCCATTCGGTCCGTAATAATTGGTGGATTATTCCCAGG
TATTCAATACCGGGTAGAGGTTGCAGCTAGTACCAGTGCAGGGGTTGGAGTAAAGAGTGAGCCACAGCCAATAATAATCGGGAGACGCAA
TGAAGTTGTCATTACTGAAAACAATAACAGCATAACTGAGCAAATCACTGATGTGGTGAAGCAACCAGCCTTTATAGCTGGTATTGGTGG
TGCCTGCTGGGTAATTCTGATGGGTTTTAGCATATGGTTGTATTGGCGAAGAAAGAAGAGGAAGGGACTCAGTAATTATGCTGTTACGTT
TCAAAGAGGAGATGGAGGACTAATGAGCAATGGAAGCCGTCCAGGTCTTCTCAATGCTGGTGATCCCAGCTATCCATGGCTTGCTGATTC
TTGGCCAGCCACGAGCTTGCCAGTAAATAATAGCAACAGTGGCCCAAATGAGATTGGAAATTTTGGCCGTGGAGATGTGCTGCCACCAGT
TCCAGGCCAAGGGGATAAAACAGCAACGATGCTCTCAGATGGAGCCATTTATAGTAGCATTGACTTCACTACCAAAACCAGTTACAACAG
TTCCAGCCAAATAACACAGGCTACCCCATATGCCACGACACAGATCTTGCATTCCAACAGCATACATGAATTGGCTGTCGATCTGCCTGA
TCCACAATGGAAAAGCTCAATTCAGCAAAAAACAGATCTGATGGGATTTGGTTATTCTCTACCTGATCAGAACAAAGGTAACAATGGTGG
GAAAGGTGGAAAAAAGAAGAAAAATAAAAACTCTTCTAAACCACAGAAAAACAATGGATCCACTTGGGCCAATGTCCCTCTACCTCCCCC
CCCAGTCCAGCCCCTTCCTGGCACGGAGCTGGAACACTATGCAGTGGAACAACAAGAAAATGGCTATGACAGTGATAGCTGGTGCCCACC
ATTGCCAGTACAAACTTACTTACACCAAGGTCTGGAAGATGAACTGGAAGAAGATGATGATAGGGTCCCAACACCTCCTGTTCGAGGCGT
GGCTTCTTCTCCTGCTATCTCCTTTGGACAGCAGTCCACTGCAACTCTTACTCCATCCCCACGGGAAGAGATGCAACCCATGCTGCAGGC
TCACCTGGATGAGTTGACAAGAGCCTATCAGTTTGATATAGCAAAACAAACATGGCACATTCAAAGCAATAATCAACCTCCACAGCCTCC
AGTTCCACCGTTAGGTTATGTGTCTGGAGCCTTGATTTCTGATTTGGAAACGGATGTTGCAGATGATGATGCCGACGACGAAGAGGAAGC
TTTAGAAATCCCCAGGCCCCTGAGAGCACTGGACCAGACTCCTGGATCCAGCATGGACAATCTAGACAGCTCTGTGACAGGTTCAATGGT
AAATGGATGGGGCTCTGCATCTGATGAGGATCGTAACTTTTCTAGTCATAGATCTAGTGTAGGTAGCTCCTCAGATGGCTCTATCTTTGC
CAGCGGCAGTTTTGCACAAGCACTGGTGGCAGCAGCAGATAAAGCTGGTTTTAGGCTGGATGGAACCAGCCTTACAAGAACAGGAAAAGC
CTTTACCTCCTCTCAAAGACCTCGACCTACCAGCCCATTTTCTACTGACAGTAACACCAGTGCAGCCCTGAGTCAAAGTCAGAGGCCTCG
GCCCACTAAAAAACACAAGGGAGGGCGGATGGACCAACAACCAGCATTGCCTCATCGAAGGGAAGGAATGACAGATGAGGAGGCCTTGGT
GCCCTATAGCAAGCCCAGTTTCCCATCTCCAGGTGGCCACAGCTCATCAGGAACAGCTTCTTCTAAGGGATCCACTGGACCTAGGAAAAC
CGAGGTGTTGAGAGCAGGCCACCAGCGCAATGCCAGCGACCTTCTTGACATAGGATATATGGGCTCCAACAGTCAAGGACAGTTTACAGG
TGAATTATAGTAAATGAGAGGAGACATACAAAGCTGCTCTGAAGGACCATCAGGTCCGGACTCATGGAAGTGATGACTCTAAACAGTGCA
ATGAACAATTTATTTATGTACTATTAAAAGAACTGTAAATGCAATGTAAAGACACACAGCCACACATATCCCACAGATATTTTCATTGTG
TTCTTCTCTTAAGTACACCACCCACCTTAACTCTTTCTTGTCAGGAGTATATAAAAAAGAAAGAAAACAAAACTCGCCCTACAGGAAGAA
AAGGATTCTCCTCTGTATATAATTTCTTTTGTGCATTGCTATGCAAGCTCACTCTTTTTAGCTCTGCTCATATTATTGTCTGTTCTTATT
GGTCTGTTGTACTATATGTGAATTAATAGGCTGTGGTGCCATATATTAACTTTTAATTGTGTAACTTTTATGTTTAAATTTTGCACTGCA
ATTTTATTTGGTGATAAGCACAAATCTCTACTCCTCATGACATGAAGAAAAAGACTGAATGTGAAGGGAGTTTCTGTACTGTAAGCTAGA
TTGGATAATGATGGCTGTAACAAATCATGTTAGATGGTTTTCAGTTGGGGTGTAGAAATAGGAAGATGCAAAGGAACAATGGTGTTGGCA
AAGTCTTCTTTGAATATCAGGGACTGAGTCAATAAAAAAAATAGTAGAAAGGTGGCTTTTACTATTGACAAAAGCCGGGGTCAAAAAAAG
TAGTTTAAGTCTTAAGACTGAATATGCATTAAAGTATGCAGGTAGCAAAGATGTAATAAATTTGCTTAAAAAAAGAAATTAAAGTTTTAT
TTAGAATCAATTTTACCTGTCATTGTAATTGACCCATCTGAGAATTACAATAAGCAAGAGGAAATTAAGGTGTTTTGCAAGAGCTGTATT
TATATTACAGTTTTTTAAAAACATTTTCTGAATTATCGTAATTAAGCTCTCCAACTCGTTAAGTCAGAATATAATATGAAGTTCCCCAAG

>98505_98505_1_VPS72-ROBO2_VPS72_chr1_151156793_ENST00000354473_ROBO2_chr3_77617464_ENST00000332191_length(amino acids)=1010AA_BP=187
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYK
EPLKSLRPRKVNTPAGSSQKAREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
ELNLRSLDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVL
VNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHIN
KTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIW
LYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLS
DGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSS
KPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQS
TATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQ
TPGSSMDNLDSSVTGSMVNGWGSASDEDRNFSSHRSSVGSSSDGSIFASGSFAQALVAAADKAGFRLDGTSLTRTGKAFTSSQRPRPTSP
FSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNAS

--------------------------------------------------------------
>98505_98505_2_VPS72-ROBO2_VPS72_chr1_151156793_ENST00000354473_ROBO2_chr3_77617464_ENST00000461745_length(transcript)=6796nt_BP=599nt
AGGGGCTGCAGGTGGCGGCGCAGTCTCGGTAGGCGGTATGAGTTTGGCTGGGGGCCGGGCACCCCGGAAGACCGCTGGGAACCGGCTTTC
TGGGCTTTTGGAGGCAGAGGAGGAAGATGAGTTCTACCAGACGACTTATGGGGGTTTCACAGAGGAATCCGGAGATGATGAGTATCAAGG
GGACCAGTCAGACACAGAGGACGAAGTGGACTCTGACTTTGACATTGATGAAGGGGATGAACCATCCAGTGATGGAGAAGCAGAAGAGCC
AAGAAGGAAGCGCCGAGTAGTCACCAAGGCCTATAAGGAACCTCTCAAGAGCTTAAGGCCTCGAAAGGTCAACACCCCGGCTGGTAGCTC
TCAGAAGGCGCGAGAAGAGAAGGCACTACTGCCATTAGAACTACAAGATGACGGCTCTGACAGTCGGAAGTCTATGCGTCAGTCTACAGC
TGAGCATACACGACAAACGTTCCTTCGGGTACAGGAGAGGCAGGGCCAGTCAAGACGGCGAAAGGGGCCCCACTGTGAGCGGCCACTAAC
CCAGGAGGAACTGCTCCGGGAGGCCAAGATCACAGAAGAGCTTAATTTACGGTCACTGGATATCAGCCCACCAGCACAAGGAGTGGACCA
CAGGCAAGTGCAGAAAGAGCTAGGAGATGTCCTTGTCCGTCTTCATAATCCAGTTGTGCTGACTCCCACCACGGTTCAGGTCACATGGAC
GGTTGATCGCCAACCCCAGTTTATCCAAGGCTACCGAGTGATGTATCGTCAGACTTCAGGTCTGCAGGCGACATCTTCGTGGCAGAATTT
AGATGCCAAAGTCCCGACTGAACGAAGTGCTGTCTTAGTCAACCTGAAAAAGGGGGTGACTTATGAAATTAAAGTACGGCCATATTTTAA
TGAGTTCCAAGGAATGGATAGTGAATCTAAAACGGTTCGTACTACTGAAGAAGCCCCAAGTGCCCCACCACAGTCTGTCACTGTACTGAC
AGTTGGAAGCTACAATAGCACAAGTATTAGTGTTTCCTGGGATCCTCCTCCTCCAGATCACCAGAATGGAATTATCCAAGAATACAAGAT
CTGGTGTCTAGGAAATGAAACGCGATTCCATATCAACAAAACTGTGGATGCAGCCATTCGGTCCGTAATAATTGGTGGATTATTCCCAGG
TATTCAATACCGGGTAGAGGTTGCAGCTAGTACCAGTGCAGGGGTTGGAGTAAAGAGTGAGCCACAGCCAATAATAATCGGGAGACGCAA
TGAAGTTGTCATTACTGAAAACAATAACAGCATAACTGAGCAAATCACTGATGTGGTGAAGCAACCAGCCTTTATAGCTGGTATTGGTGG
TGCCTGCTGGGTAATTCTGATGGGTTTTAGCATATGGTTGTATTGGCGAAGAAAGAAGAGGAAGGGACTCAGTAATTATGCTGTTACGTT
TCAAAGAGGAGATGGAGGACTAATGAGCAATGGAAGCCGTCCAGGTCTTCTCAATGCTGGTGATCCCAGCTATCCATGGCTTGCTGATTC
TTGGCCAGCCACGAGCTTGCCAGTAAATAATAGCAACAGTGGCCCAAATGAGATTGGAAATTTTGGCCGTGGAGATGTGCTGCCACCAGT
TCCAGGCCAAGGGGATAAAACAGCAACGATGCTCTCAGATGGAGCCATTTATAGTAGCATTGACTTCACTACCAAAACCAGTTACAACAG
TTCCAGCCAAATAACACAGGCTACCCCATATGCCACGACACAGATCTTGCATTCCAACAGCATACATGAATTGGCTGTCGATCTGCCTGA
TCCACAATGGAAAAGCTCAATTCAGCAAAAAACAGATCTGATGGGATTTGGTTATTCTCTACCTGATCAGAACAAAGGTAACAATGGTGG
GAAAGGTGGAAAAAAGAAGAAAAATAAAAACTCTTCTAAACCACAGAAAAACAATGGATCCACTTGGGCCAATGTCCCTCTACCTCCCCC
CCCAGTCCAGCCCCTTCCTGGCACGGAGCTGGAACACTATGCAGTGGAACAACAAGAAAATGGCTATGACAGTGATAGCTGGTGCCCACC
ATTGCCAGTACAAACTTACTTACACCAAGGTCTGGAAGATGAACTGGAAGAAGATGATGATAGGGTCCCAACACCTCCTGTTCGAGGCGT
GGCTTCTTCTCCTGCTATCTCCTTTGGACAGCAGTCCACTGCAACTCTTACTCCATCCCCACGGGAAGAGATGCAACCCATGCTGCAGGC
TCACCTGGATGAGTTGACAAGAGCCTATCAGTTTGATATAGCAAAACAAACATGGCACATTCAAAGCAATAATCAACCTCCACAGCCTCC
AGTTCCACCGTTAGGTTATGTGTCTGGAGCCTTGATTTCTGATTTGGAAACGGATGTTGCAGATGATGATGCCGACGACGAAGAGGAAGC
TTTAGAAATCCCCAGGCCCCTGAGAGCACTGGACCAGACTCCTGGATCCAGCATGGACAATCTAGACAGCTCTGTGACAGGAAAAGCCTT
TACCTCCTCTCAAAGACCTCGACCTACCAGCCCATTTTCTACTGACAGTAACACCAGTGCAGCCCTGAGTCAAAGTCAGAGGCCTCGGCC
CACTAAAAAACACAAGGGAGGGCGGATGGACCAACAACCAGCATTGCCTCATCGAAGGGAAGGAATGACAGATGAGGAGGCCTTGGTGCC
CTATAGCAAGCCCAGTTTCCCATCTCCAGGTGGCCACAGCTCATCAGGAACAGCTTCTTCTAAGGGATCCACTGGACCTAGGAAAACCGA
GGTGTTGAGAGCAGGCCACCAGCGCAATGCCAGCGACCTTCTTGACATAGGATATATGGGCTCCAACAGTCAAGGACAGTTTACAGGTGA
ATTATAGTAAATGAGAGGAGACATACAAAGCTGCTCTGAAGGACCATCAGGTCCGGACTCATGGAAGTGATGACTCTAAACAGTGCAATG
AACAATTTATTTATGTACTATTAAAAGAACTGTAAATGCAATGTAAAGACACACAGCCACACATATCCCACAGATATTTTCATTGTGTTC
TTCTCTTAAGTACACCACCCACCTTAACTCTTTCTTGTCAGGAGTATATAAAAAAGAAAGAAAACAAAACTCGCCCTACAGGAAGAAAAG
GATTCTCCTCTGTATATAATTTCTTTTGTGCATTGCTATGCAAGCTCACTCTTTTTAGCTCTGCTCATATTATTGTCTGTTCTTATTGGT
CTGTTGTACTATATGTGAATTAATAGGCTGTGGTGCCATATATTAACTTTTAATTGTGTAACTTTTATGTTTAAATTTTGCACTGCAATT
TTATTTGGTGATAAGCACAAATCTCTACTCCTCATGACATGAAGAAAAAGACTGAATGTGAAGGGAGTTTCTGTACTGTAAGCTAGATTG
GATAATGATGGCTGTAACAAATCATGTTAGATGGTTTTCAGTTGGGGTGTAGAAATAGGAAGATGCAAAGGAACAATGGTGTTGGCAAAG
TCTTCTTTGAATATCAGGGACTGAGTCAATAAAAAAAATAGTAGAAAGGTGGCTTTTACTATTGACAAAAGCCGGGGTCAAAAAAAGTAG
TTTAAGTCTTAAGACTGAATATGCATTAAAGTATGCAGGTAGCAAAGATGTAATAAATTTGCTTAAAAAAAGAAATTAAAGTTTTATTTA
GAATCAATTTTACCTGTCATTGTAATTGACCCATCTGAGAATTACAATAAGCAAGAGGAAATTAAGGTGTTTTGCAAGAGCTGTATTTAT
ATTACAGTTTTTTAAAAACATTTTCTGAATTATCGTAATTAAGCTCTCCAACTCGTTAAGTCAGAATATAATATGAAGTTCCCCAAGGAA
ACGAACAAAATGAACTCTAGAATATCTAGCAAATAGTTAAAGAAGCAATTTATTATTAGGGCATACTCGGGCTGTTTCCAAATATAAACT
CTATTGCAATATCTTATTTCATCTTTCTAATACATGTACAGTGCACACTAGAGGATAGAGCTGCATCACTTAAATTCATGACTTAAAAAA
TAATACAGTTTATATACAACTTGTTTTTTATTTGATTAAGAAGTGAAGTTTACGCCACCCAATGTATAGCCAAATTGTACGTGCTTAAAA
AACAGTGCCGAGAGTATGTTCAGTTCGCAGTAAGTAGATTTATTGGAATAAATATTCTATGGTACATTCTCAGAAATTGGCTTCCAACTA
AAATACGTTTGACCCATTTTGAATAAGGAAATTGAAAAGAAAAATTTAAAAGGAGAAAAAAATGCATGTTTATAAACTTTTTAAATAAAA
CCAGACCTTGTAAGTGGACATTAATAATTGTCCTGCCTCATTTGTTTTCACGACTTTGACAACAAGAAGTTCCTGAACATTAGTCATGTA
TGCTCAGAATAAATGTGACTTTGAAATATATGTTAGCTACTGTACATGTATAGTCAGTCAAGTAGAAGAGGACCTTCCTGAAATTCCCAC
TTGTGACATTTTCCCATGGGTTTCCTACACAATCTTAAATTTTATTTCTGTCTATACTTTCTCAAATTTTTCCTATGATAAGTTCAGTTG
TTGGTACTCTTCTAAAAATATTCAACGTGATTAGGATCAGTTCTAAAATACGGGACCCCTTTGAGTGACAATTCGCACTCCATGCATTAT
TGGCTCAGTAGCCAATTTTTGTCACGTCGTTATAACAAGGAGATGACATAATTAAACATTTCCATCCTTTCTATTCCCTGAGACTGCATC
AGCACAGGCAAGTATAGAATGTAATGTTCTTCATGGGCCCCACCAGCTTTTTGGTGCCATGTAATTTATTTCTTCGCTGAAGAGAAAAAG
AATTCTGAGACACAGTTATTAAACCCTTTATCAACTTTCTACCATCAGTGCCTGAATTCTAATGCAGTGTGATTTCTCTGGGACAAAGAG
ACTGAGGAAGATGAAAAGTTTCTTCAAAGAGTGAATACATACTTATTCACAACTCTAGGATGTGAGGACTTTAAATATCTCTTTATGAAG
TTCCCTGCCTAACCTCTTTCTATTTAAAGGCAAACAAATTTCGAAGAGGTTTTGTGTTCCCTCTTTATGTTTCTCTATGACCCAGTTTAG
TCTAAAACCTTAGTTCATTACATATACAACACATAGCCTTTGATCCCTGGTAACTGGCAGGTGTTGGTGATTAATAAACCAAGGCTTCAA
AGTGAAGTATGTGTGTGCAGATGACTTTTGGAATAACGTGGGCATAGCATCATACCTTCCTGATTGTCTTCAGCATATAAAAATTAACTG
TTGTAGTTAAAATTATGTCAGTGCAGAGCTTGTGGTTACTTGGAATGTTCTTTCAGAATAGTCCATGTTGCCTATTAAACCTAGTTTTAA
ACACATTGGGCAGTCAATTTATGCACCCAAAATATCACCCTCAGGTAGATTGAGGGCAAGATAAAATGCTGTATGTAGCTATACAAAGGA
ATTCAGAAACATTACTGGAAAGCAAAGCCTTTGTCAGCTTGCTACTGACAAAGTAGTAAAAAGCTACTAATCAGTGTTGAGTCAGATGTC
AACAGAAAAATACAAATACCTATGAGAGCCACAGCAGTTTCTCGTTTCATAGCCGATTCAATGAATATGATTAGAAATTCACTGAGCTCA
CTCTTGCAGGTTTAAATGGAGGCCTGCATAAGGACTGCAAGAGGAAATCTGGGTGGGAGAGAATGTAATCTGATCTTGCACTCATAGGCA
ATGCTGCAATGCAATCATGTCCAATACAAGCACAGCTTCATTCATAACAGGAAACGTCTTCTTTGGGAAAATAGCTCTATTGGTGCCCAA
ACTCAGGTATGCCAGTGTATGCAGGTGGAGTCGCCCTACCCCTCTTCCAAACATGTCCTGTGAGATTTTTAAAATAAGATGGGATAGTAC
AGGGGCATGAAAAGAATTGATTCCTTCACAGGATTTGAATCCAGTTCAAGGGAGAATGTAGAAAATTCAAAACCAACATATAAGGTATCA
CACAACCAAGAAAAGTAAAACCATTGCAAGTTTACTTGCGTTGAGTACAAAACAGATTTAATGGTGTTCTATGTCATAGTTTAATGCTCT
GGGTATTTAAATATGTTTTCAACAGGATTTGAGTTGAAAGTTTGTAATGTGCTTTGATGGAACACCTCTCAATTTCTATTCAATAAACTT
ATGTAATTGTCCATTGACAATATAATGATAACAGTACCATTGAACTCTAAACTGTGGTTTATCTTCACTACTGGGAAGCAACTGTGCATC
AGTATTAAAGATATGCAGAAACATAATATTCACTAATTTGTTCATCTGCTTCTGTATATTGTTTATGGAATTACATGGCAAGAACTGTTC
TAAAGCAACATGTCTTTCCACATTATTTTAGAGGTGAAATTACTTTTGTTTTGCTTCTCTATAATGTGTACTTCAAATGAAACACCATAC
TTTTTTCTAAAAAAAGATGTTCAATTTACTAATTTTTTTAAATCTCATAATTTAAAAAGCATTTGTTGTGATTTTAAAGTGTTGCAAGAA
AAGGGATTTTGTGGCCGTGGGTAGACTTTTTATACTTTGTTTTATAGATGGATTTTTTTTAACTGTAGTTTGTTTAAGTCACCAAGCAGC
ATCCAAAATCTTAATGTGTTTCATTTGATGTTGTTAGATCAGAGAAGAAATTGGCATAAAATCGGTTAATAGTATTGTCAAAGAATTGTG

>98505_98505_2_VPS72-ROBO2_VPS72_chr1_151156793_ENST00000354473_ROBO2_chr3_77617464_ENST00000461745_length(amino acids)=949AA_BP=187
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYK
EPLKSLRPRKVNTPAGSSQKAREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
ELNLRSLDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVL
VNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHIN
KTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIW
LYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLS
DGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSS
KPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQS
TATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQ
TPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGH

--------------------------------------------------------------
>98505_98505_3_VPS72-ROBO2_VPS72_chr1_151156793_ENST00000354473_ROBO2_chr3_77617464_ENST00000487694_length(transcript)=4342nt_BP=599nt
AGGGGCTGCAGGTGGCGGCGCAGTCTCGGTAGGCGGTATGAGTTTGGCTGGGGGCCGGGCACCCCGGAAGACCGCTGGGAACCGGCTTTC
TGGGCTTTTGGAGGCAGAGGAGGAAGATGAGTTCTACCAGACGACTTATGGGGGTTTCACAGAGGAATCCGGAGATGATGAGTATCAAGG
GGACCAGTCAGACACAGAGGACGAAGTGGACTCTGACTTTGACATTGATGAAGGGGATGAACCATCCAGTGATGGAGAAGCAGAAGAGCC
AAGAAGGAAGCGCCGAGTAGTCACCAAGGCCTATAAGGAACCTCTCAAGAGCTTAAGGCCTCGAAAGGTCAACACCCCGGCTGGTAGCTC
TCAGAAGGCGCGAGAAGAGAAGGCACTACTGCCATTAGAACTACAAGATGACGGCTCTGACAGTCGGAAGTCTATGCGTCAGTCTACAGC
TGAGCATACACGACAAACGTTCCTTCGGGTACAGGAGAGGCAGGGCCAGTCAAGACGGCGAAAGGGGCCCCACTGTGAGCGGCCACTAAC
CCAGGAGGAACTGCTCCGGGAGGCCAAGATCACAGAAGAGCTTAATTTACGGTCACTGGATATCAGCCCACCAGCACAAGGAGTGGACCA
CAGGCAAGTGCAGAAAGAGCTAGGAGATGTCCTTGTCCGTCTTCATAATCCAGTTGTGCTGACTCCCACCACGGTTCAGGTCACATGGAC
GGTTGATCGCCAACCCCAGTTTATCCAAGGCTACCGAGTGATGTATCGTCAGACTTCAGGTCTGCAGGCGACATCTTCGTGGCAGAATTT
AGATGCCAAAGTCCCGACTGAACGAAGTGCTGTCTTAGTCAACCTGAAAAAGGGGGTGACTTATGAAATTAAAGTACGGCCATATTTTAA
TGAGTTCCAAGGAATGGATAGTGAATCTAAAACGGTTCGTACTACTGAAGAAGCCCCAAGTGCCCCACCACAGTCTGTCACTGTACTGAC
AGTTGGAAGCTACAATAGCACAAGTATTAGTGTTTCCTGGGATCCTCCTCCTCCAGATCACCAGAATGGAATTATCCAAGAATACAAGAT
CTGGTGTCTAGGAAATGAAACGCGATTCCATATCAACAAAACTGTGGATGCAGCCATTCGGTCCGTAATAATTGGTGGATTATTCCCAGG
TATTCAATACCGGGTAGAGGTTGCAGCTAGTACCAGTGCAGGGGTTGGAGTAAAGAGTGAGCCACAGCCAATAATAATCGGGAGACGCAA
TGAAGTTGTCATTACTGAAAACAATAACAGCATAACTGAGCAAATCACTGATGTGGTGAAGCAACCAGCCTTTATAGCTGGTATTGGTGG
TGCCTGCTGGGTAATTCTGATGGGTTTTAGCATATGGTTGTATTGGCGAAGAAAGAAGAGGAAGGGACTCAGTAATTATGCTGTTACGTT
TCAAAGAGGAGATGGAGGACTAATGAGCAATGGAAGCCGTCCAGGTCTTCTCAATGCTGGTGATCCCAGCTATCCATGGCTTGCTGATTC
TTGGCCAGCCACGAGCTTGCCAGTAAATAATAGCAACAGTGGCCCAAATGAGATTGGAAATTTTGGCCGTGGAGATGTGCTGCCACCAGT
TCCAGGCCAAGGGGATAAAACAGCAACGATGCTCTCAGATGGAGCCATTTATAGTAGCATTGACTTCACTACCAAAACCAGTTACAACAG
TTCCAGCCAAATAACACAGGCTACCCCATATGCCACGACACAGATCTTGCATTCCAACAGCATACATGAATTGGCTGTCGATCTGCCTGA
TCCACAATGGAAAAGCTCAATTCAGCAAAAAACAGATCTGATGGGATTTGGTTATTCTCTACCTGATCAGAACAAAGGTAACAATGGTGG
GAAAGGTGGAAAAAAGAAGAAAAATAAAAACTCTTCTAAACCACAGAAAAACAATGGATCCACTTGGGCCAATGTCCCTCTACCTCCCCC
CCCAGTCCAGCCCCTTCCTGGCACGGAGCTGGAACACTATGCAGTGGAACAACAAGAAAATGGCTATGACAGTGATAGCTGGTGCCCACC
ATTGCCAGTACAAACTTACTTACACCAAGGTCTGGAAGATGAACTGGAAGAAGATGATGATAGGGTCCCAACACCTCCTGTTCGAGGCGT
GGCTTCTTCTCCTGCTATCTCCTTTGGACAGCAGTCCACTGCAACTCTTACTCCATCCCCACGGGAAGAGATGCAACCCATGCTGCAGGC
TCACCTGGATGAGTTGACAAGAGCCTATCAGTTTGATATAGCAAAACAAACATGGCACATTCAAAGCAATAATCAACCTCCACAGCCTCC
AGTTCCACCGTTAGGTTATGTGTCTGGAGCCTTGATTTCTGATTTGGAAACGGATGTTGCAGATGATGATGCCGACGACGAAGAGGAAGC
TTTAGAAATCCCCAGGCCCCTGAGAGCACTGGACCAGACTCCTGGATCCAGCATGGACAATCTAGACAGCTCTGTGACAGGAAAAGCCTT
TACCTCCTCTCAAAGACCTCGACCTACCAGCCCATTTTCTACTGACAGTAACACCAGTGCAGCCCTGAGTCAAAGTCAGAGGCCTCGGCC
CACTAAAAAACACAAGGGAGGGCGGATGGACCAACAACCAGCATTGCCTCATCGAAGGGAAGGAATGACAGATGAGGAGGCCTTGGTGCC
CTATAGCAAGCCCAGTTTCCCATCTCCAGGTGGCCACAGCTCATCAGGAACAGCTTCTTCTAAGGGATCCACTGGACCTAGGAAAACCGA
GGTGTTGAGAGCAGGCCACCAGCGCAATGCCAGCGACCTTCTTGACATAGGATATATGGGCTCCAACAGTCAAGGACAGTTTACAGGTGA
ATTATAGTAAATGAGAGGAGACATACAAAGCTGCTCTGAAGGACCATCAGGTCCGGACTCATGGAAGTGATGACTCTAAACAGTGCAATG
AACAATTTATTTATGTACTATTAAAAGAACTGTAAATGCAATGTAAAGACACACAGCCACACATATCCCACAGATATTTTCATTGTGTTC
TTCTCTTAAGTACACCACCCACCTTAACTCTTTCTTGTCAGGAGTATATAAAAAAGAAAGAAAACAAAACTCGCCCTACAGGAAGAAAAG
GATTCTCCTCTGTATATAATTTCTTTTGTGCATTGCTATGCAAGCTCACTCTTTTTAGCTCTGCTCATATTATTGTCTGTTCTTATTGGT
CTGTTGTACTATATGTGAATTAATAGGCTGTGGTGCCATATATTAACTTTTAATTGTGTAACTTTTATGTTTAAATTTTGCACTGCAATT
TTATTTGGTGATAAGCACAAATCTCTACTCCTCATGACATGAAGAAAAAGACTGAATGTGAAGGGAGTTTCTGTACTGTAAGCTAGATTG
GATAATGATGGCTGTAACAAATCATGTTAGATGGTTTTCAGTTGGGGTGTAGAAATAGGAAGATGCAAAGGAACAATGGTGTTGGCAAAG
TCTTCTTTGAATATCAGGGACTGAGTCAATAAAAAAAATAGTAGAAAGGTGGCTTTTACTATTGACAAAAGCCGGGGTCAAAAAAAGTAG
TTTAAGTCTTAAGACTGAATATGCATTAAAGTATGCAGGTAGCAAAGATGTAATAAATTTGCTTAAAAAAAGAAATTAAAGTTTTATTTA
GAATCAATTTTACCTGTCATTGTAATTGACCCATCTGAGAATTACAATAAGCAAGAGGAAATTAAGGTGTTTTGCAAGAGCTGTATTTAT
ATTACAGTTTTTTAAAAACATTTTCTGAATTATCGTAATTAAGCTCTCCAACTCGTTAAGTCAGAATATAATATGAAGTTCCCCAAGGAA
ACGAACAAAATGAACTCTAGAATATCTAGCAAATAGTTAAAGAAGCAATTTATTATTAGGGCATACTCGGGCTGTTTCCAAATATAAACT
CTATTGCAATATCTTATTTCATCTTTCTAATACATGTACAGTGCACACTAGAGGATAGAGCTGCATCACTTAAATTCATGACTTAAAAAA
TAATACAGTTTATATACAACTTGTTTTTTATTTGATTAAGAAGTGAAGTTTACGCCACCCAATGTATAGCCAAATTGTACGTGCTTAAAA
AACAGTGCCGAGAGTATGTTCAGTTCGCAGTAAGTAGATTTATTGGAATAAATATTCTATGGTACATTCTCAGAAATTGGCTTCCAACTA
AAATACGTTTGACCCATTTTGAATAAGGAAATTGAAAAGAAAAATTTAAAAGGAGAAAAAAATGCATGTTTATAAACTTTTTAAATAAAA

>98505_98505_3_VPS72-ROBO2_VPS72_chr1_151156793_ENST00000354473_ROBO2_chr3_77617464_ENST00000487694_length(amino acids)=949AA_BP=187
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYK
EPLKSLRPRKVNTPAGSSQKAREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
ELNLRSLDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVL
VNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHIN
KTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIW
LYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLS
DGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSS
KPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQS
TATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQ
TPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for VPS72-ROBO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VPS72-ROBO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VPS72-ROBO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource