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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VPS8-PSMD2 (FusionGDB2 ID:98521)

Fusion Gene Summary for VPS8-PSMD2

check button Fusion gene summary
Fusion gene informationFusion gene name: VPS8-PSMD2
Fusion gene ID: 98521
HgeneTgene
Gene symbol

VPS8

PSMD2

Gene ID

23355

5708

Gene nameVPS8 subunit of CORVET complexproteasome 26S subunit, non-ATPase 2
SynonymsKIAA0804P97|RPN1|S2|TRAP2
Cytomap

3q27.2

3q27.1

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 8 homologVPS8, CORVET complex subunitvacuolar protein sorting 8 homolog26S proteasome non-ATPase regulatory subunit 255.11 proteinTNFR-associated protein 2proteasome (prosome, macropain) 26S subunit, non-ATPase, 2protein 55.11tumor necrosis factor type 1 receptor-associated protein 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000287546, ENST00000436792, 
ENST00000437079, ENST00000446204, 
ENST00000424463, ENST00000463687, 
ENST00000459910, ENST00000435761, 
ENST00000439383, ENST00000310118, 
Fusion gene scores* DoF score15 X 8 X 7=8407 X 8 X 3=168
# samples 178
** MAII scorelog2(17/840*10)=-2.30485458152842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VPS8 [Title/Abstract] AND PSMD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVPS8(184742177)-PSMD2(184019324), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across VPS8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PSMD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-6709VPS8chr3

184742177

+PSMD2chr3

184019324

+


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Fusion Gene ORF analysis for VPS8-PSMD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000287546ENST00000459910VPS8chr3

184742177

+PSMD2chr3

184019324

+
5CDS-3UTRENST00000436792ENST00000459910VPS8chr3

184742177

+PSMD2chr3

184019324

+
5CDS-3UTRENST00000437079ENST00000459910VPS8chr3

184742177

+PSMD2chr3

184019324

+
5CDS-3UTRENST00000446204ENST00000459910VPS8chr3

184742177

+PSMD2chr3

184019324

+
5CDS-5UTRENST00000287546ENST00000435761VPS8chr3

184742177

+PSMD2chr3

184019324

+
5CDS-5UTRENST00000287546ENST00000439383VPS8chr3

184742177

+PSMD2chr3

184019324

+
5CDS-5UTRENST00000436792ENST00000435761VPS8chr3

184742177

+PSMD2chr3

184019324

+
5CDS-5UTRENST00000436792ENST00000439383VPS8chr3

184742177

+PSMD2chr3

184019324

+
5CDS-5UTRENST00000437079ENST00000435761VPS8chr3

184742177

+PSMD2chr3

184019324

+
5CDS-5UTRENST00000437079ENST00000439383VPS8chr3

184742177

+PSMD2chr3

184019324

+
5CDS-5UTRENST00000446204ENST00000435761VPS8chr3

184742177

+PSMD2chr3

184019324

+
5CDS-5UTRENST00000446204ENST00000439383VPS8chr3

184742177

+PSMD2chr3

184019324

+
In-frameENST00000287546ENST00000310118VPS8chr3

184742177

+PSMD2chr3

184019324

+
In-frameENST00000436792ENST00000310118VPS8chr3

184742177

+PSMD2chr3

184019324

+
In-frameENST00000437079ENST00000310118VPS8chr3

184742177

+PSMD2chr3

184019324

+
In-frameENST00000446204ENST00000310118VPS8chr3

184742177

+PSMD2chr3

184019324

+
intron-3CDSENST00000424463ENST00000310118VPS8chr3

184742177

+PSMD2chr3

184019324

+
intron-3CDSENST00000463687ENST00000310118VPS8chr3

184742177

+PSMD2chr3

184019324

+
intron-3UTRENST00000424463ENST00000459910VPS8chr3

184742177

+PSMD2chr3

184019324

+
intron-3UTRENST00000463687ENST00000459910VPS8chr3

184742177

+PSMD2chr3

184019324

+
intron-5UTRENST00000424463ENST00000435761VPS8chr3

184742177

+PSMD2chr3

184019324

+
intron-5UTRENST00000424463ENST00000439383VPS8chr3

184742177

+PSMD2chr3

184019324

+
intron-5UTRENST00000463687ENST00000435761VPS8chr3

184742177

+PSMD2chr3

184019324

+
intron-5UTRENST00000463687ENST00000439383VPS8chr3

184742177

+PSMD2chr3

184019324

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000437079VPS8chr3184742177+ENST00000310118PSMD2chr3184019324+6761422715365962147
ENST00000287546VPS8chr3184742177+ENST00000310118PSMD2chr3184019324+6761422715365962147
ENST00000436792VPS8chr3184742177+ENST00000310118PSMD2chr3184019324+6727419312565622145
ENST00000446204VPS8chr3184742177+ENST00000310118PSMD2chr3184019324+6445391111362802055

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000437079ENST00000310118VPS8chr3184742177+PSMD2chr3184019324+0.0020076010.9979924
ENST00000287546ENST00000310118VPS8chr3184742177+PSMD2chr3184019324+0.0019753090.9980247
ENST00000436792ENST00000310118VPS8chr3184742177+PSMD2chr3184019324+0.0018983420.99810165
ENST00000446204ENST00000310118VPS8chr3184742177+PSMD2chr3184019324+0.0021355760.9978644

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Fusion Genomic Features for VPS8-PSMD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
VPS8chr3184742177+PSMD2chr3184019324+1.46E-050.99998546
VPS8chr3184742177+PSMD2chr3184019324+1.46E-050.99998546

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for VPS8-PSMD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:184742177/chr3:184019324)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVPS8chr3:184742177chr3:184019324ENST00000436792+4547195_23613501427.0RepeatNote=WD
HgeneVPS8chr3:184742177chr3:184019324ENST00000437079+4648195_23613521429.0RepeatNote=WD
HgeneVPS8chr3:184742177chr3:184019324ENST00000446204+4345195_23612601337.0RepeatNote=WD
HgeneVPS8chr3:184742177chr3:184019324ENST00000436792+45471258_131013501427.0Zinc fingerRING-type%3B atypical
HgeneVPS8chr3:184742177chr3:184019324ENST00000437079+46481258_131013521429.0Zinc fingerRING-type%3B atypical
TgenePSMD2chr3:184742177chr3:184019324ENST00000310118221623_641119909.0Compositional biasNote=Glu/Lys-rich
TgenePSMD2chr3:184742177chr3:184019324ENST00000310118221409_442119909.0RepeatNote=PC 1
TgenePSMD2chr3:184742177chr3:184019324ENST00000310118221443_479119909.0RepeatNote=PC 2
TgenePSMD2chr3:184742177chr3:184019324ENST00000310118221480_514119909.0RepeatNote=PC 3
TgenePSMD2chr3:184742177chr3:184019324ENST00000310118221517_551119909.0RepeatNote=PC 4
TgenePSMD2chr3:184742177chr3:184019324ENST00000310118221560_589119909.0RepeatNote=PC 5
TgenePSMD2chr3:184742177chr3:184019324ENST00000310118221692_723119909.0RepeatNote=PC 6
TgenePSMD2chr3:184742177chr3:184019324ENST00000310118221742_757119909.0RepeatNote=PC 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVPS8chr3:184742177chr3:184019324ENST00000446204+43451258_131012601337.0Zinc fingerRING-type%3B atypical


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Fusion Gene Sequence for VPS8-PSMD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98521_98521_1_VPS8-PSMD2_VPS8_chr3_184742177_ENST00000287546_PSMD2_chr3_184019324_ENST00000310118_length(transcript)=6761nt_BP=4227nt
AGGTAGTGCGCGTGCGTGAGGCTAGAGCAGTGGGTGCGGTCACGTGGGCCGGCGGTCCACGGCCGGAATGGCAGCAAGCTCAGAGATAAT
CATTCAGGTCTTCGTGAGCTAAGGCCAAACAAACAAAAAACACTTGCTTTGATGGACTGAATACTGTTATTAGAAGTAAATATGGAAAAT
GAACCAGACCATGAAAATGTGGAACAGAGCCTCTGTGCCAAGACGAGCGAAGAAGAGCTGAATAAGTCTTTCAATCTAGAAGCTTCACTT
TCAAAATTCTCTTACATAGATATGGACAAGGAACTGGAGTTCAAAAATGATCTGATTGATGACAAGGAGTTTGATATTCCTCAAGTTGAT
ACTCCTCCAACACTGGAAAGCATACTAAATGAGACTGATGATGAAGATGAGTCTTTTATTCTTGAGGATCCTACATTGTTAAACATTGAT
ACTATTGATTCTCACTCCTATGATACTTCATCTGTGGCAAGCTCAGATAGTGGTGACAGGACCAACTTAAAAAGGAAGAAGAAATTACCT
GATTCTTTTTCACTTCATGGATCAGTTATGCGCCATTCACTTTTGAAGGGAATTTCTGCCCAGATAGTGTCTGCAGCTGACAAAGTAGAT
GCTGGCTTGCCTACAGCAATTGCAGTATCCAGTCTGATAGCAGTGGGTACATCTCATGGATTGGCTTTAATATTTGGTAAATATCAGAAT
CAAGCTTTGCGACTCTGTCTGGGTAGCACTAGTGTTGGAGGTCAGTATGGCGCTATCTCTGCCCTCAGTATCAACAATGATTGCTCAAGA
CTTCTTTGTGGCTTTGCTAAAGGACAGATCACCATGTGGGATTTGGCCAGTGGAAAACTTCTAAGATCAATAACAGATGCTCATCCTCCA
GGAACAGCAATATTGCATATCAAGTTTACAGATGATCCAACTCTTGCAATTTGCAACGACAGCGGAGGCTCTGTTTTTGAATTGACATTT
AAGAGAGTGATGGGAGTGAGAACCTGTGAATCTAGATGTCTGTTCAGTGGTTCCAAGGGTGAAGTCTGCTGTATTGAGCCTCTGCATTCT
AAGCCTGAGTTGAAAGATCATCCCATCACACAGTTTTCATTATTGGCCATGGCATCCTTGACAAAAATACTGGTCATTGGATTGAAACCA
TCCTTGAAAGTATGGATGACTTTTCCCTATGGCCGGATGGATCCTTCCAGTGTGCCACTGCTGGCCTGGCACTTTGTAGCAGTACAAAAT
TACGTGAATCCCATGCTTGCCTTCTGCAGAGGAGATGTTGTTCATTTTCTATTGGTAAAGAGAGATGAATCTGGAGCAATACATGTTACT
AAGCAAAAGCATCTTCACCTATACTATGACCTCATCAACTTTACCTGGATAAATTCACGCACAGTTGTGCTCTTAGACAGCGTAGAGAAG
TTGCATGTGATTGATCGGCAAACACAAGAGGAATTGGAGACAGTGGAGATCTCAGAAGTTCAGCTGGTCTACAATAGCAGCCATTTCAAA
TCACTAGCCACTGGAGGAAATGTTAGCCAGGCACTGGCTTTGGTTGGAGAGAAGGCTTGTTATCAATCCATCAGTAGCTATGGTGGTCAG
ATCTTTTATTTGGGGACAAAATCTGTTTATGTGATGATGCTGAGGAGCTGGAGAGAGAGAGTGGATCATCTCCTGAAACAAGATTGTCTT
ACAGAAGCGTTGGCTCTTGCGTGGTCTTTCCATGAAGGAAAAGCAAAAGCAGTAGTGGGATTATCAGGGGATGCCAGTAAGCGAAAGGCT
ATTGTTGCAGACCGGATGGTAGAAATCCTATTCCATTATGCAGATCGAGCTCTGAAAAAGTGCCCAGACCAAGGAAAAATCCAAGTGATG
GAGCAGCATTTTCAGGATATGGTGCCTGTCATAGTTGATTACTGCCTTCTGCTGCAGCGAAAGGATCTTTTATTTAGTCAGATGTATGAT
AAATTAAGTGAGAATTCAGTGGCCAAAGGAGTATTTTTGGAGTGCCTTGAGCCATATATTTTAAGTGATAAATTGGTGGGAATCACACCC
CAAGTAATGAAAGACTTGATTGTTCATTTCCAAGATAAAAAATTAATGGAAAATGTGGAAGCGCTCATTGTACATATGGATATCACCAGC
CTAGATATTCAGCAGGTAGTTCTCATGTGTTGGGAAAATCGTTTATATGATGCTATGATCTATGTCTACAACAGAGGCATGAATGAATTT
ATTAGTCCAATGGAGAAACTTTTCAGAGTCATTGCTCCTCCTCTGAATGCAGGAAAAACACTAACAGATGAACAAGTTGTTATGGGCAAT
AAGCTCCTTGTATATATTAGCTGTTGTCTAGCAGGTCGTGCCTATCCCCTTGGTGACATCCCTGAAGATCTGGTTCCCTTGGTTAAAAAC
CAGGTTTTTGAATTTCTAATTCGCCTGCATTCAGCAGAGGCTTCTCCTGAGGAAGAAATCTATCCTTACATTCGGACTTTGCTACATTTT
GACACAAGAGAATTTCTAAATGTATTGGCACTGACTTTTGAAGATTTTAAAAATGACAAGCAAGCTGTGGAATATCAACAGCGAATTGTG
GATATTTTGTTGAAAGTTATGGTGGAGAATTCAGACTTTACCCCCTCACAAGTAGGATGTCTCTTTACCTTCCTTGCTCGGCAGCTTGCA
AAGCCTGACAACACCTTGTTTGTAAACAGAACACTTTTTGATCAGGTCCTTGAATTCCTTTGTAGTCCTGACGATGACTCCCGACACTCT
GAAAGACAGCAGGTCCTTTTAGAATTGCTGCAGGCTGGAGGCATAGTTCAATTTGAAGAGAGTCGACTCATCCGGATGGCAGAAAAAGCT
GAGTTCTATCAAATTTGTGAATTTATGTATGAAAGAGAACACCAATATGATAAAATTATTGATTGCTACTTACGTGACCCTCTGCGAGAG
GAAGAAGTCTTTAATTACATTCACAATATCTTATCCATTCCCGGACACAGTGCAGAGGAGAAGCAGTCTGTATGGCAGAAAGCAATGGAT
CATATTGAGGAACTCGTGTCCCTGAAGCCTTGTAAAGCTGCGGAGCTGGTTGCCACCCACTTTTCTGGACATATTGAAACGGTCATTAAA
AAACTTCAGAACCAGGTTTTGCTTTTCAAATTTTTGAGGAGTCTTCTTGACCCAAGGGAAGGTATTCATGTAAATCAAGAATTACTGCAA
ATATCTCCTTGTATCACAGAGCAGTTCATTGAGCTGTTGTGTCAGTTCAACCCAACCCAAGTTATAGAGACTCTGCAAGTCCTTGAGTGC
TACCGTCTGGAAGAAACTATTCAGATTACTCAGAAGTATCAACTTCATGAAGTCACCGCTTATCTATTGGAAAAGAAAGGAGATATTCAT
GGTGCCTTCCTAATAATGTTAGAGAGACTACAAAGCAAACTTCAAGAGGTAACACATCAAGGTGAAAATACCAAAGAGGATCCCTCATTG
AAGGATGTTGAAGATACTATGGTGGAGACCATTGCTCTTTGCCAGAGAAATTCACATAATTTGAACCAGCAGCAACGTGAGGCACTTTGG
TTTCCGTTATTGGAGGCAATGATGGCCCCTCAGAAGCTGTCCAGTTCAGCCATTCCTCATCTACACTCTGAAGCTCTGAAGTCTTTGACC
ATGCAAGTTTTAAATAGCATGGCAGCATTTATTGCCCTTCCATCAATCTTGCAAAGAATCTTACAGGATCCAGTTTATGGAAAAGGAAAA
CTTGGAGAAATCCAGGGACTTATCTTGGGAATGTTAGATACCTTTAACTATGAACAAACCCTGCTGGAAACAACAACCAGCCTTCTAAAC
CAAGATCTCCATTGGTCATTGTGTAACCTGAGAGCTTCGGTCACCAGAGGACTGAATCCCAAACAAGATTACTGCTCTATATGTTTGCAG
CAGTACAAGAGACGCCAAGAAATGGCTGATGAAATAATTGTCTTTAGCTGTGGCCATTTGTATCACTCATTCTGCCTACAAAACAAAGAA
TGCACTGTGGAATTTGAGGGCCAAACAAGATGGACATGCTACAAATGCAGTTCAAGTAACAAAGTAGGAAAACTCAGTGAAAATTCATCT
GAAATTAAAAAGGGAAGGATAACCCCATCACAGGTAAAAATGTCTCCATCGTATCATCAGTCCAAAGGGGATCCCACTGCTAAAAAGCGT
TTTGCTGCTGACATCATCTCCGTTTTGGCCATGACCATGAGTGGGGAGCGTGAGTGCCTCAAGTATCGGCTAGTGGGCTCCCAGGAGGAA
TTGGCATCATGGGGTCATGAGTATGTCAGGCATCTGGCAGGAGAAGTGGCTAAGGAGTGGCAGGAGCTGGATGACGCAGAGAAGGTCCAG
CGGGAGCCTCTGCTCACTCTGGTGAAGGAAATCGTCCCCTATAACATGGCCCACAATGCAGAGCATGAGGCTTGCGACCTGCTTATGGAA
ATTGAGCAGGTGGACATGCTGGAGAAGGACATTGATGAAAATGCATATGCAAAGGTCTGCCTTTATCTCACCAGTTGTGTGAATTACGTG
CCTGAGCCTGAGAACTCAGCCCTACTGCGTTGTGCCCTGGGTGTGTTCCGAAAGTTTAGCCGCTTCCCTGAAGCTCTGAGATTGGCATTG
ATGCTCAATGACATGGAGTTGGTAGAAGACATCTTCACCTCCTGCAAGGATGTGGTAGTACAGAAACAGATGGCATTCATGCTAGGCCGG
CATGGGGTGTTCCTGGAGCTGAGTGAAGATGTCGAGGAGTATGAGGACCTGACAGAGATCATGTCCAATGTACAGCTCAACAGCAACTTC
TTGGCCTTAGCTCGGGAGCTGGACATCATGGAGCCCAAGGTGCCTGATGACATCTACAAAACCCACCTAGAGAACAACAGGTTTGGGGGC
AGTGGCTCTCAGGTGGACTCTGCCCGCATGAACCTGGCCTCCTCTTTTGTGAATGGCTTTGTGAATGCAGCTTTTGGCCAAGACAAGCTG
CTAACAGATGATGGCAACAAATGGCTTTACAAGAACAAGGACCACGGAATGTTGAGTGCAGCTGCATCTCTTGGGATGATTCTGCTGTGG
GATGTGGATGGTGGCCTCACCCAGATTGACAAGTACCTGTACTCCTCTGAGGACTACATTAAGTCAGGAGCTCTTCTTGCCTGTGGCATA
GTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATGTTCTCCACAACAGCAACACCATGAGACTTGGT
TCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACACTGCTGCTGCCTGTGATGGGAGATTCAAAGTCC
AGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCTGCAATGGAGATGTAACTTCCACTATCCTTCAG
ACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTCTTGGACTGGGTCTCAACCACCTGGGGAAGGGT
GAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTTTTGCCAACACACTGGTGGATGTGTGTGCATAT
GCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACTTTGACTCCAAAGAGAAGGAGGAAGACAAAGAC
AAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATCAGGGAGTGGCTGTTCTGGGGATTGCCCTTATT
GCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGAGATATGGGGAGCCTACACTCCGGAGGGCTGTA
CCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCCTAAGCAAATTCTCTCATGATGCTGATCCAGAA
GTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCCGTCTGGCTGCAATGCTGCGCCAGTTAGCTCAA
TATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACACATTTAGGGAAGGGCACCCTTACCCTCTGCCCC
TACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGCTTGTCTCTTTCCTGGATGTTCGAAACATTATT
CTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGCTGGTTACGTTTGATGAGGAGCTGCGGCCATTG
CCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGAAGACTATCACAGGGTTCCAGACGCATACAACC
CCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTGTTACCCCCATTCTGGAAGGTTTTGTTATCCTT
CGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGATGTTATCAGCAGGCCATGCATCCTGCTGCCAA
GGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTCTTTTGTTACTGAGTGAGATAAGGTTGTTCAATAAAGACTTTTA

>98521_98521_1_VPS8-PSMD2_VPS8_chr3_184742177_ENST00000287546_PSMD2_chr3_184019324_ENST00000310118_length(amino acids)=2147AA_BP=1358
MLLEVNMENEPDHENVEQSLCAKTSEEELNKSFNLEASLSKFSYIDMDKELEFKNDLIDDKEFDIPQVDTPPTLESILNETDDEDESFIL
EDPTLLNIDTIDSHSYDTSSVASSDSGDRTNLKRKKKLPDSFSLHGSVMRHSLLKGISAQIVSAADKVDAGLPTAIAVSSLIAVGTSHGL
ALIFGKYQNQALRLCLGSTSVGGQYGAISALSINNDCSRLLCGFAKGQITMWDLASGKLLRSITDAHPPGTAILHIKFTDDPTLAICNDS
GGSVFELTFKRVMGVRTCESRCLFSGSKGEVCCIEPLHSKPELKDHPITQFSLLAMASLTKILVIGLKPSLKVWMTFPYGRMDPSSVPLL
AWHFVAVQNYVNPMLAFCRGDVVHFLLVKRDESGAIHVTKQKHLHLYYDLINFTWINSRTVVLLDSVEKLHVIDRQTQEELETVEISEVQ
LVYNSSHFKSLATGGNVSQALALVGEKACYQSISSYGGQIFYLGTKSVYVMMLRSWRERVDHLLKQDCLTEALALAWSFHEGKAKAVVGL
SGDASKRKAIVADRMVEILFHYADRALKKCPDQGKIQVMEQHFQDMVPVIVDYCLLLQRKDLLFSQMYDKLSENSVAKGVFLECLEPYIL
SDKLVGITPQVMKDLIVHFQDKKLMENVEALIVHMDITSLDIQQVVLMCWENRLYDAMIYVYNRGMNEFISPMEKLFRVIAPPLNAGKTL
TDEQVVMGNKLLVYISCCLAGRAYPLGDIPEDLVPLVKNQVFEFLIRLHSAEASPEEEIYPYIRTLLHFDTREFLNVLALTFEDFKNDKQ
AVEYQQRIVDILLKVMVENSDFTPSQVGCLFTFLARQLAKPDNTLFVNRTLFDQVLEFLCSPDDDSRHSERQQVLLELLQAGGIVQFEES
RLIRMAEKAEFYQICEFMYEREHQYDKIIDCYLRDPLREEEVFNYIHNILSIPGHSAEEKQSVWQKAMDHIEELVSLKPCKAAELVATHF
SGHIETVIKKLQNQVLLFKFLRSLLDPREGIHVNQELLQISPCITEQFIELLCQFNPTQVIETLQVLECYRLEETIQITQKYQLHEVTAY
LLEKKGDIHGAFLIMLERLQSKLQEVTHQGENTKEDPSLKDVEDTMVETIALCQRNSHNLNQQQREALWFPLLEAMMAPQKLSSSAIPHL
HSEALKSLTMQVLNSMAAFIALPSILQRILQDPVYGKGKLGEIQGLILGMLDTFNYEQTLLETTTSLLNQDLHWSLCNLRASVTRGLNPK
QDYCSICLQQYKRRQEMADEIIVFSCGHLYHSFCLQNKECTVEFEGQTRWTCYKCSSSNKVGKLSENSSEIKKGRITPSQVKMSPSYHQS
KGDPTAKKRFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKVQREPLLTLVKEIVPYNMAHNAE
HEACDLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQ
KQMAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFV
NAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVL
HNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLG
LGLNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQG
VAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARL
AAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLV

--------------------------------------------------------------
>98521_98521_2_VPS8-PSMD2_VPS8_chr3_184742177_ENST00000436792_PSMD2_chr3_184019324_ENST00000310118_length(transcript)=6727nt_BP=4193nt
AGTGGGTGCGGTCACGTGGGCCGGCGGTCCACGGCCGGAATGGCAGCAAGCTCAGAGATAATCATTCAGGTCTTCGTGAGCTAAGGCCAA
ACAAACAAAAAACACTTGCTTTGATGGACTGAATACTGTTATTAGAAGTAAATATGGAAAATGAACCAGACCATGAAAATGTGGAACAGA
GCCTCTGTGCCAAGACGAGCGAAGAAGAGCTGAATAAGTCTTTCAATCTAGAAGCTTCACTTTCAAAATTCTCTTACATAGATATGGACA
AGGAACTGGAGTTCAAAAATGATCTGATTGATGACAAGGAGTTTGATATTCCTCAAGTTGATACTCCTCCAACACTGGAAAGCATACTAA
ATGAGACTGATGATGAAGATGAGTCTTTTATTCTTGAGGATCCTACATTGTTAAACATTGATACTATTGATTCTCACTCCTATGATACTT
CATCTGTGGCAAGCTCAGATAGTGGTGACAGGACCAACTTAAAAAGGAAGAAGAAATTACCTGATTCTTTTTCACTTCATGGATCAGTTA
TGCGCCATTCACTTTTGAAGGGAATTTCTGCCCAGATAGTGTCTGCAGCTGACAAAGTAGATGCTGGCTTGCCTACAGCAATTGCAGTAT
CCAGTCTGATAGCAGTGGGTACATCTCATGGATTGGCTTTAATATTTGATCAGAATCAAGCTTTGCGACTCTGTCTGGGTAGCACTAGTG
TTGGAGGTCAGTATGGCGCTATCTCTGCCCTCAGTATCAACAATGATTGCTCAAGACTTCTTTGTGGCTTTGCTAAAGGACAGATCACCA
TGTGGGATTTGGCCAGTGGAAAACTTCTAAGATCAATAACAGATGCTCATCCTCCAGGAACAGCAATATTGCATATCAAGTTTACAGATG
ATCCAACTCTTGCAATTTGCAACGACAGCGGAGGCTCTGTTTTTGAATTGACATTTAAGAGAGTGATGGGAGTGAGAACCTGTGAATCTA
GATGTCTGTTCAGTGGTTCCAAGGGTGAAGTCTGCTGTATTGAGCCTCTGCATTCTAAGCCTGAGTTGAAAGATCATCCCATCACACAGT
TTTCATTATTGGCCATGGCATCCTTGACAAAAATACTGGTCATTGGATTGAAACCATCCTTGAAAGTATGGATGACTTTTCCCTATGGCC
GGATGGATCCTTCCAGTGTGCCACTGCTGGCCTGGCACTTTGTAGCAGTACAAAATTACGTGAATCCCATGCTTGCCTTCTGCAGAGGAG
ATGTTGTTCATTTTCTATTGGTAAAGAGAGATGAATCTGGAGCAATACATGTTACTAAGCAAAAGCATCTTCACCTATACTATGACCTCA
TCAACTTTACCTGGATAAATTCACGCACAGTTGTGCTCTTAGACAGCGTAGAGAAGTTGCATGTGATTGATCGGCAAACACAAGAGGAAT
TGGAGACAGTGGAGATCTCAGAAGTTCAGCTGGTCTACAATAGCAGCCATTTCAAATCACTAGCCACTGGAGGAAATGTTAGCCAGGCAC
TGGCTTTGGTTGGAGAGAAGGCTTGTTATCAATCCATCAGTAGCTATGGTGGTCAGATCTTTTATTTGGGGACAAAATCTGTTTATGTGA
TGATGCTGAGGAGCTGGAGAGAGAGAGTGGATCATCTCCTGAAACAAGATTGTCTTACAGAAGCGTTGGCTCTTGCGTGGTCTTTCCATG
AAGGAAAAGCAAAAGCAGTAGTGGGATTATCAGGGGATGCCAGTAAGCGAAAGGCTATTGTTGCAGACCGGATGGTAGAAATCCTATTCC
ATTATGCAGATCGAGCTCTGAAAAAGTGCCCAGACCAAGGAAAAATCCAAGTGATGGAGCAGCATTTTCAGGATATGGTGCCTGTCATAG
TTGATTACTGCCTTCTGCTGCAGCGAAAGGATCTTTTATTTAGTCAGATGTATGATAAATTAAGTGAGAATTCAGTGGCCAAAGGAGTAT
TTTTGGAGTGCCTTGAGCCATATATTTTAAGTGATAAATTGGTGGGAATCACACCCCAAGTAATGAAAGACTTGATTGTTCATTTCCAAG
ATAAAAAATTAATGGAAAATGTGGAAGCGCTCATTGTACATATGGATATCACCAGCCTAGATATTCAGCAGGTAGTTCTCATGTGTTGGG
AAAATCGTTTATATGATGCTATGATCTATGTCTACAACAGAGGCATGAATGAATTTATTAGTCCAATGGAGAAACTTTTCAGAGTCATTG
CTCCTCCTCTGAATGCAGGAAAAACACTAACAGATGAACAAGTTGTTATGGGCAATAAGCTCCTTGTATATATTAGCTGTTGTCTAGCAG
GTCGTGCCTATCCCCTTGGTGACATCCCTGAAGATCTGGTTCCCTTGGTTAAAAACCAGGTTTTTGAATTTCTAATTCGCCTGCATTCAG
CAGAGGCTTCTCCTGAGGAAGAAATCTATCCTTACATTCGGACTTTGCTACATTTTGACACAAGAGAATTTCTAAATGTATTGGCACTGA
CTTTTGAAGATTTTAAAAATGACAAGCAAGCTGTGGAATATCAACAGCGAATTGTGGATATTTTGTTGAAAGTTATGGTGGAGAATTCAG
ACTTTACCCCCTCACAAGTAGGATGTCTCTTTACCTTCCTTGCTCGGCAGCTTGCAAAGCCTGACAACACCTTGTTTGTAAACAGAACAC
TTTTTGATCAGGTCCTTGAATTCCTTTGTAGTCCTGACGATGACTCCCGACACTCTGAAAGACAGCAGGTCCTTTTAGAATTGCTGCAGG
CTGGAGGCATAGTTCAATTTGAAGAGAGTCGACTCATCCGGATGGCAGAAAAAGCTGAGTTCTATCAAATTTGTGAATTTATGTATGAAA
GAGAACACCAATATGATAAAATTATTGATTGCTACTTACGTGACCCTCTGCGAGAGGAAGAAGTCTTTAATTACATTCACAATATCTTAT
CCATTCCCGGACACAGTGCAGAGGAGAAGCAGTCTGTATGGCAGAAAGCAATGGATCATATTGAGGAACTCGTGTCCCTGAAGCCTTGTA
AAGCTGCGGAGCTGGTTGCCACCCACTTTTCTGGACATATTGAAACGGTCATTAAAAAACTTCAGAACCAGGTTTTGCTTTTCAAATTTT
TGAGGAGTCTTCTTGACCCAAGGGAAGGTATTCATGTAAATCAAGAATTACTGCAAATATCTCCTTGTATCACAGAGCAGTTCATTGAGC
TGTTGTGTCAGTTCAACCCAACCCAAGTTATAGAGACTCTGCAAGTCCTTGAGTGCTACCGTCTGGAAGAAACTATTCAGATTACTCAGA
AGTATCAACTTCATGAAGTCACCGCTTATCTATTGGAAAAGAAAGGAGATATTCATGGTGCCTTCCTAATAATGTTAGAGAGACTACAAA
GCAAACTTCAAGAGGTAACACATCAAGGTGAAAATACCAAAGAGGATCCCTCATTGAAGGATGTTGAAGATACTATGGTGGAGACCATTG
CTCTTTGCCAGAGAAATTCACATAATTTGAACCAGCAGCAACGTGAGGCACTTTGGTTTCCGTTATTGGAGGCAATGATGGCCCCTCAGA
AGCTGTCCAGTTCAGCCATTCCTCATCTACACTCTGAAGCTCTGAAGTCTTTGACCATGCAAGTTTTAAATAGCATGGCAGCATTTATTG
CCCTTCCATCAATCTTGCAAAGAATCTTACAGGATCCAGTTTATGGAAAAGGAAAACTTGGAGAAATCCAGGGACTTATCTTGGGAATGT
TAGATACCTTTAACTATGAACAAACCCTGCTGGAAACAACAACCAGCCTTCTAAACCAAGATCTCCATTGGTCATTGTGTAACCTGAGAG
CTTCGGTCACCAGAGGACTGAATCCCAAACAAGATTACTGCTCTATATGTTTGCAGCAGTACAAGAGACGCCAAGAAATGGCTGATGAAA
TAATTGTCTTTAGCTGTGGCCATTTGTATCACTCATTCTGCCTACAAAACAAAGAATGCACTGTGGAATTTGAGGGCCAAACAAGATGGA
CATGCTACAAATGCAGTTCAAGTAACAAAGTAGGAAAACTCAGTGAAAATTCATCTGAAATTAAAAAGGGAAGGATAACCCCATCACAGG
TAAAAATGTCTCCATCGTATCATCAGTCCAAAGGGGATCCCACTGCTAAAAAGCGTTTTGCTGCTGACATCATCTCCGTTTTGGCCATGA
CCATGAGTGGGGAGCGTGAGTGCCTCAAGTATCGGCTAGTGGGCTCCCAGGAGGAATTGGCATCATGGGGTCATGAGTATGTCAGGCATC
TGGCAGGAGAAGTGGCTAAGGAGTGGCAGGAGCTGGATGACGCAGAGAAGGTCCAGCGGGAGCCTCTGCTCACTCTGGTGAAGGAAATCG
TCCCCTATAACATGGCCCACAATGCAGAGCATGAGGCTTGCGACCTGCTTATGGAAATTGAGCAGGTGGACATGCTGGAGAAGGACATTG
ATGAAAATGCATATGCAAAGGTCTGCCTTTATCTCACCAGTTGTGTGAATTACGTGCCTGAGCCTGAGAACTCAGCCCTACTGCGTTGTG
CCCTGGGTGTGTTCCGAAAGTTTAGCCGCTTCCCTGAAGCTCTGAGATTGGCATTGATGCTCAATGACATGGAGTTGGTAGAAGACATCT
TCACCTCCTGCAAGGATGTGGTAGTACAGAAACAGATGGCATTCATGCTAGGCCGGCATGGGGTGTTCCTGGAGCTGAGTGAAGATGTCG
AGGAGTATGAGGACCTGACAGAGATCATGTCCAATGTACAGCTCAACAGCAACTTCTTGGCCTTAGCTCGGGAGCTGGACATCATGGAGC
CCAAGGTGCCTGATGACATCTACAAAACCCACCTAGAGAACAACAGGTTTGGGGGCAGTGGCTCTCAGGTGGACTCTGCCCGCATGAACC
TGGCCTCCTCTTTTGTGAATGGCTTTGTGAATGCAGCTTTTGGCCAAGACAAGCTGCTAACAGATGATGGCAACAAATGGCTTTACAAGA
ACAAGGACCACGGAATGTTGAGTGCAGCTGCATCTCTTGGGATGATTCTGCTGTGGGATGTGGATGGTGGCCTCACCCAGATTGACAAGT
ACCTGTACTCCTCTGAGGACTACATTAAGTCAGGAGCTCTTCTTGCCTGTGGCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTG
CTCTGGCACTGCTCTCAGACTATGTTCTCCACAACAGCAACACCATGAGACTTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCT
CAAATCGTGAAGATGTCCTAACACTGCTGCTGCCTGTGATGGGAGATTCAAAGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCT
GTGGAATGATAGCAGTAGGGTCCTGCAATGGAGATGTAACTTCCACTATCCTTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGG
ATACTTATGCTCGTTGGCTTCCTCTTGGACTGGGTCTCAACCACCTGGGGAAGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGG
TTGTGTCAGAGCCATTCCGCAGTTTTGCCAACACACTGGTGGATGTGTGTGCATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGC
TGCTCCACATTTGTAGCGAACACTTTGACTCCAAAGAGAAGGAGGAAGACAAAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAG
CCCCTGCTGACATGGGAGCACATCAGGGAGTGGCTGTTCTGGGGATTGCCCTTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCAT
TACGAACCTTTGGCCACTTGCTGAGATATGGGGAGCCTACACTCCGGAGGGCTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATC
CACGACTCAACATCCTGGATACCCTAAGCAAATTCTCTCATGATGCTGATCCAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGG
TGGGCAGTGGTACCAATAATGCCCGTCTGGCTGCAATGCTGCGCCAGTTAGCTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGG
TGCGCTTGGCACAGGGCCTGACACATTTAGGGAAGGGCACCCTTACCCTCTGCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGG
CCGTGGCTGGACTGCTCACTGTGCTTGTCTCTTTCCTGGATGTTCGAAACATTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGG
TGGCTGCCATGCAGCCCCGAATGCTGGTTACGTTTGATGAGGAGCTGCGGCCATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATG
TGGTGGGCCAGGCTGGCAAGCCGAAGACTATCACAGGGTTCCAGACGCATACAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAAT
TGGCCACTGAGGAGTTTCTTCCTGTTACCCCCATTCTGGAAGGTTTTGTTATCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCA
CCAGGGGCTCTGAACTGCAGCTGATGTTATCAGCAGGCCATGCATCCTGCTGCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTG

>98521_98521_2_VPS8-PSMD2_VPS8_chr3_184742177_ENST00000436792_PSMD2_chr3_184019324_ENST00000310118_length(amino acids)=2145AA_BP=1356
MLLEVNMENEPDHENVEQSLCAKTSEEELNKSFNLEASLSKFSYIDMDKELEFKNDLIDDKEFDIPQVDTPPTLESILNETDDEDESFIL
EDPTLLNIDTIDSHSYDTSSVASSDSGDRTNLKRKKKLPDSFSLHGSVMRHSLLKGISAQIVSAADKVDAGLPTAIAVSSLIAVGTSHGL
ALIFDQNQALRLCLGSTSVGGQYGAISALSINNDCSRLLCGFAKGQITMWDLASGKLLRSITDAHPPGTAILHIKFTDDPTLAICNDSGG
SVFELTFKRVMGVRTCESRCLFSGSKGEVCCIEPLHSKPELKDHPITQFSLLAMASLTKILVIGLKPSLKVWMTFPYGRMDPSSVPLLAW
HFVAVQNYVNPMLAFCRGDVVHFLLVKRDESGAIHVTKQKHLHLYYDLINFTWINSRTVVLLDSVEKLHVIDRQTQEELETVEISEVQLV
YNSSHFKSLATGGNVSQALALVGEKACYQSISSYGGQIFYLGTKSVYVMMLRSWRERVDHLLKQDCLTEALALAWSFHEGKAKAVVGLSG
DASKRKAIVADRMVEILFHYADRALKKCPDQGKIQVMEQHFQDMVPVIVDYCLLLQRKDLLFSQMYDKLSENSVAKGVFLECLEPYILSD
KLVGITPQVMKDLIVHFQDKKLMENVEALIVHMDITSLDIQQVVLMCWENRLYDAMIYVYNRGMNEFISPMEKLFRVIAPPLNAGKTLTD
EQVVMGNKLLVYISCCLAGRAYPLGDIPEDLVPLVKNQVFEFLIRLHSAEASPEEEIYPYIRTLLHFDTREFLNVLALTFEDFKNDKQAV
EYQQRIVDILLKVMVENSDFTPSQVGCLFTFLARQLAKPDNTLFVNRTLFDQVLEFLCSPDDDSRHSERQQVLLELLQAGGIVQFEESRL
IRMAEKAEFYQICEFMYEREHQYDKIIDCYLRDPLREEEVFNYIHNILSIPGHSAEEKQSVWQKAMDHIEELVSLKPCKAAELVATHFSG
HIETVIKKLQNQVLLFKFLRSLLDPREGIHVNQELLQISPCITEQFIELLCQFNPTQVIETLQVLECYRLEETIQITQKYQLHEVTAYLL
EKKGDIHGAFLIMLERLQSKLQEVTHQGENTKEDPSLKDVEDTMVETIALCQRNSHNLNQQQREALWFPLLEAMMAPQKLSSSAIPHLHS
EALKSLTMQVLNSMAAFIALPSILQRILQDPVYGKGKLGEIQGLILGMLDTFNYEQTLLETTTSLLNQDLHWSLCNLRASVTRGLNPKQD
YCSICLQQYKRRQEMADEIIVFSCGHLYHSFCLQNKECTVEFEGQTRWTCYKCSSSNKVGKLSENSSEIKKGRITPSQVKMSPSYHQSKG
DPTAKKRFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKVQREPLLTLVKEIVPYNMAHNAEHE
ACDLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQKQ
MAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNA
AFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHN
SNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLG
LNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVA
VLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAA
MLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTF

--------------------------------------------------------------
>98521_98521_3_VPS8-PSMD2_VPS8_chr3_184742177_ENST00000437079_PSMD2_chr3_184019324_ENST00000310118_length(transcript)=6761nt_BP=4227nt
AGGTAGTGCGCGTGCGTGAGGCTAGAGCAGTGGGTGCGGTCACGTGGGCCGGCGGTCCACGGCCGGAATGGCAGCAAGCTCAGAGATAAT
CATTCAGGTCTTCGTGAGCTAAGGCCAAACAAACAAAAAACACTTGCTTTGATGGACTGAATACTGTTATTAGAAGTAAATATGGAAAAT
GAACCAGACCATGAAAATGTGGAACAGAGCCTCTGTGCCAAGACGAGCGAAGAAGAGCTGAATAAGTCTTTCAATCTAGAAGCTTCACTT
TCAAAATTCTCTTACATAGATATGGACAAGGAACTGGAGTTCAAAAATGATCTGATTGATGACAAGGAGTTTGATATTCCTCAAGTTGAT
ACTCCTCCAACACTGGAAAGCATACTAAATGAGACTGATGATGAAGATGAGTCTTTTATTCTTGAGGATCCTACATTGTTAAACATTGAT
ACTATTGATTCTCACTCCTATGATACTTCATCTGTGGCAAGCTCAGATAGTGGTGACAGGACCAACTTAAAAAGGAAGAAGAAATTACCT
GATTCTTTTTCACTTCATGGATCAGTTATGCGCCATTCACTTTTGAAGGGAATTTCTGCCCAGATAGTGTCTGCAGCTGACAAAGTAGAT
GCTGGCTTGCCTACAGCAATTGCAGTATCCAGTCTGATAGCAGTGGGTACATCTCATGGATTGGCTTTAATATTTGGAAAAGATCAGAAT
CAAGCTTTGCGACTCTGTCTGGGTAGCACTAGTGTTGGAGGTCAGTATGGCGCTATCTCTGCCCTCAGTATCAACAATGATTGCTCAAGA
CTTCTTTGTGGCTTTGCTAAAGGACAGATCACCATGTGGGATTTGGCCAGTGGAAAACTTCTAAGATCAATAACAGATGCTCATCCTCCA
GGAACAGCAATATTGCATATCAAGTTTACAGATGATCCAACTCTTGCAATTTGCAACGACAGCGGAGGCTCTGTTTTTGAATTGACATTT
AAGAGAGTGATGGGAGTGAGAACCTGTGAATCTAGATGTCTGTTCAGTGGTTCCAAGGGTGAAGTCTGCTGTATTGAGCCTCTGCATTCT
AAGCCTGAGTTGAAAGATCATCCCATCACACAGTTTTCATTATTGGCCATGGCATCCTTGACAAAAATACTGGTCATTGGATTGAAACCA
TCCTTGAAAGTATGGATGACTTTTCCCTATGGCCGGATGGATCCTTCCAGTGTGCCACTGCTGGCCTGGCACTTTGTAGCAGTACAAAAT
TACGTGAATCCCATGCTTGCCTTCTGCAGAGGAGATGTTGTTCATTTTCTATTGGTAAAGAGAGATGAATCTGGAGCAATACATGTTACT
AAGCAAAAGCATCTTCACCTATACTATGACCTCATCAACTTTACCTGGATAAATTCACGCACAGTTGTGCTCTTAGACAGCGTAGAGAAG
TTGCATGTGATTGATCGGCAAACACAAGAGGAATTGGAGACAGTGGAGATCTCAGAAGTTCAGCTGGTCTACAATAGCAGCCATTTCAAA
TCACTAGCCACTGGAGGAAATGTTAGCCAGGCACTGGCTTTGGTTGGAGAGAAGGCTTGTTATCAATCCATCAGTAGCTATGGTGGTCAG
ATCTTTTATTTGGGGACAAAATCTGTTTATGTGATGATGCTGAGGAGCTGGAGAGAGAGAGTGGATCATCTCCTGAAACAAGATTGTCTT
ACAGAAGCGTTGGCTCTTGCGTGGTCTTTCCATGAAGGAAAAGCAAAAGCAGTAGTGGGATTATCAGGGGATGCCAGTAAGCGAAAGGCT
ATTGTTGCAGACCGGATGGTAGAAATCCTATTCCATTATGCAGATCGAGCTCTGAAAAAGTGCCCAGACCAAGGAAAAATCCAAGTGATG
GAGCAGCATTTTCAGGATATGGTGCCTGTCATAGTTGATTACTGCCTTCTGCTGCAGCGAAAGGATCTTTTATTTAGTCAGATGTATGAT
AAATTAAGTGAGAATTCAGTGGCCAAAGGAGTATTTTTGGAGTGCCTTGAGCCATATATTTTAAGTGATAAATTGGTGGGAATCACACCC
CAAGTAATGAAAGACTTGATTGTTCATTTCCAAGATAAAAAATTAATGGAAAATGTGGAAGCGCTCATTGTACATATGGATATCACCAGC
CTAGATATTCAGCAGGTAGTTCTCATGTGTTGGGAAAATCGTTTATATGATGCTATGATCTATGTCTACAACAGAGGCATGAATGAATTT
ATTAGTCCAATGGAGAAACTTTTCAGAGTCATTGCTCCTCCTCTGAATGCAGGAAAAACACTAACAGATGAACAAGTTGTTATGGGCAAT
AAGCTCCTTGTATATATTAGCTGTTGTCTAGCAGGTCGTGCCTATCCCCTTGGTGACATCCCTGAAGATCTGGTTCCCTTGGTTAAAAAC
CAGGTTTTTGAATTTCTAATTCGCCTGCATTCAGCAGAGGCTTCTCCTGAGGAAGAAATCTATCCTTACATTCGGACTTTGCTACATTTT
GACACAAGAGAATTTCTAAATGTATTGGCACTGACTTTTGAAGATTTTAAAAATGACAAGCAAGCTGTGGAATATCAACAGCGAATTGTG
GATATTTTGTTGAAAGTTATGGTGGAGAATTCAGACTTTACCCCCTCACAAGTAGGATGTCTCTTTACCTTCCTTGCTCGGCAGCTTGCA
AAGCCTGACAACACCTTGTTTGTAAACAGAACACTTTTTGATCAGGTCCTTGAATTCCTTTGTAGTCCTGACGATGACTCCCGACACTCT
GAAAGACAGCAGGTCCTTTTAGAATTGCTGCAGGCTGGAGGCATAGTTCAATTTGAAGAGAGTCGACTCATCCGGATGGCAGAAAAAGCT
GAGTTCTATCAAATTTGTGAATTTATGTATGAAAGAGAACACCAATATGATAAAATTATTGATTGCTACTTACGTGACCCTCTGCGAGAG
GAAGAAGTCTTTAATTACATTCACAATATCTTATCCATTCCCGGACACAGTGCAGAGGAGAAGCAGTCTGTATGGCAGAAAGCAATGGAT
CATATTGAGGAACTCGTGTCCCTGAAGCCTTGTAAAGCTGCGGAGCTGGTTGCCACCCACTTTTCTGGACATATTGAAACGGTCATTAAA
AAACTTCAGAACCAGGTTTTGCTTTTCAAATTTTTGAGGAGTCTTCTTGACCCAAGGGAAGGTATTCATGTAAATCAAGAATTACTGCAA
ATATCTCCTTGTATCACAGAGCAGTTCATTGAGCTGTTGTGTCAGTTCAACCCAACCCAAGTTATAGAGACTCTGCAAGTCCTTGAGTGC
TACCGTCTGGAAGAAACTATTCAGATTACTCAGAAGTATCAACTTCATGAAGTCACCGCTTATCTATTGGAAAAGAAAGGAGATATTCAT
GGTGCCTTCCTAATAATGTTAGAGAGACTACAAAGCAAACTTCAAGAGGTAACACATCAAGGTGAAAATACCAAAGAGGATCCCTCATTG
AAGGATGTTGAAGATACTATGGTGGAGACCATTGCTCTTTGCCAGAGAAATTCACATAATTTGAACCAGCAGCAACGTGAGGCACTTTGG
TTTCCGTTATTGGAGGCAATGATGGCCCCTCAGAAGCTGTCCAGTTCAGCCATTCCTCATCTACACTCTGAAGCTCTGAAGTCTTTGACC
ATGCAAGTTTTAAATAGCATGGCAGCATTTATTGCCCTTCCATCAATCTTGCAAAGAATCTTACAGGATCCAGTTTATGGAAAAGGAAAA
CTTGGAGAAATCCAGGGACTTATCTTGGGAATGTTAGATACCTTTAACTATGAACAAACCCTGCTGGAAACAACAACCAGCCTTCTAAAC
CAAGATCTCCATTGGTCATTGTGTAACCTGAGAGCTTCGGTCACCAGAGGACTGAATCCCAAACAAGATTACTGCTCTATATGTTTGCAG
CAGTACAAGAGACGCCAAGAAATGGCTGATGAAATAATTGTCTTTAGCTGTGGCCATTTGTATCACTCATTCTGCCTACAAAACAAAGAA
TGCACTGTGGAATTTGAGGGCCAAACAAGATGGACATGCTACAAATGCAGTTCAAGTAACAAAGTAGGAAAACTCAGTGAAAATTCATCT
GAAATTAAAAAGGGAAGGATAACCCCATCACAGGTAAAAATGTCTCCATCGTATCATCAGTCCAAAGGGGATCCCACTGCTAAAAAGCGT
TTTGCTGCTGACATCATCTCCGTTTTGGCCATGACCATGAGTGGGGAGCGTGAGTGCCTCAAGTATCGGCTAGTGGGCTCCCAGGAGGAA
TTGGCATCATGGGGTCATGAGTATGTCAGGCATCTGGCAGGAGAAGTGGCTAAGGAGTGGCAGGAGCTGGATGACGCAGAGAAGGTCCAG
CGGGAGCCTCTGCTCACTCTGGTGAAGGAAATCGTCCCCTATAACATGGCCCACAATGCAGAGCATGAGGCTTGCGACCTGCTTATGGAA
ATTGAGCAGGTGGACATGCTGGAGAAGGACATTGATGAAAATGCATATGCAAAGGTCTGCCTTTATCTCACCAGTTGTGTGAATTACGTG
CCTGAGCCTGAGAACTCAGCCCTACTGCGTTGTGCCCTGGGTGTGTTCCGAAAGTTTAGCCGCTTCCCTGAAGCTCTGAGATTGGCATTG
ATGCTCAATGACATGGAGTTGGTAGAAGACATCTTCACCTCCTGCAAGGATGTGGTAGTACAGAAACAGATGGCATTCATGCTAGGCCGG
CATGGGGTGTTCCTGGAGCTGAGTGAAGATGTCGAGGAGTATGAGGACCTGACAGAGATCATGTCCAATGTACAGCTCAACAGCAACTTC
TTGGCCTTAGCTCGGGAGCTGGACATCATGGAGCCCAAGGTGCCTGATGACATCTACAAAACCCACCTAGAGAACAACAGGTTTGGGGGC
AGTGGCTCTCAGGTGGACTCTGCCCGCATGAACCTGGCCTCCTCTTTTGTGAATGGCTTTGTGAATGCAGCTTTTGGCCAAGACAAGCTG
CTAACAGATGATGGCAACAAATGGCTTTACAAGAACAAGGACCACGGAATGTTGAGTGCAGCTGCATCTCTTGGGATGATTCTGCTGTGG
GATGTGGATGGTGGCCTCACCCAGATTGACAAGTACCTGTACTCCTCTGAGGACTACATTAAGTCAGGAGCTCTTCTTGCCTGTGGCATA
GTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATGTTCTCCACAACAGCAACACCATGAGACTTGGT
TCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACACTGCTGCTGCCTGTGATGGGAGATTCAAAGTCC
AGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCTGCAATGGAGATGTAACTTCCACTATCCTTCAG
ACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTCTTGGACTGGGTCTCAACCACCTGGGGAAGGGT
GAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTTTTGCCAACACACTGGTGGATGTGTGTGCATAT
GCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACTTTGACTCCAAAGAGAAGGAGGAAGACAAAGAC
AAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATCAGGGAGTGGCTGTTCTGGGGATTGCCCTTATT
GCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGAGATATGGGGAGCCTACACTCCGGAGGGCTGTA
CCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCCTAAGCAAATTCTCTCATGATGCTGATCCAGAA
GTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCCGTCTGGCTGCAATGCTGCGCCAGTTAGCTCAA
TATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACACATTTAGGGAAGGGCACCCTTACCCTCTGCCCC
TACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGCTTGTCTCTTTCCTGGATGTTCGAAACATTATT
CTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGCTGGTTACGTTTGATGAGGAGCTGCGGCCATTG
CCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGAAGACTATCACAGGGTTCCAGACGCATACAACC
CCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTGTTACCCCCATTCTGGAAGGTTTTGTTATCCTT
CGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGATGTTATCAGCAGGCCATGCATCCTGCTGCCAA
GGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTCTTTTGTTACTGAGTGAGATAAGGTTGTTCAATAAAGACTTTTA

>98521_98521_3_VPS8-PSMD2_VPS8_chr3_184742177_ENST00000437079_PSMD2_chr3_184019324_ENST00000310118_length(amino acids)=2147AA_BP=1358
MLLEVNMENEPDHENVEQSLCAKTSEEELNKSFNLEASLSKFSYIDMDKELEFKNDLIDDKEFDIPQVDTPPTLESILNETDDEDESFIL
EDPTLLNIDTIDSHSYDTSSVASSDSGDRTNLKRKKKLPDSFSLHGSVMRHSLLKGISAQIVSAADKVDAGLPTAIAVSSLIAVGTSHGL
ALIFGKDQNQALRLCLGSTSVGGQYGAISALSINNDCSRLLCGFAKGQITMWDLASGKLLRSITDAHPPGTAILHIKFTDDPTLAICNDS
GGSVFELTFKRVMGVRTCESRCLFSGSKGEVCCIEPLHSKPELKDHPITQFSLLAMASLTKILVIGLKPSLKVWMTFPYGRMDPSSVPLL
AWHFVAVQNYVNPMLAFCRGDVVHFLLVKRDESGAIHVTKQKHLHLYYDLINFTWINSRTVVLLDSVEKLHVIDRQTQEELETVEISEVQ
LVYNSSHFKSLATGGNVSQALALVGEKACYQSISSYGGQIFYLGTKSVYVMMLRSWRERVDHLLKQDCLTEALALAWSFHEGKAKAVVGL
SGDASKRKAIVADRMVEILFHYADRALKKCPDQGKIQVMEQHFQDMVPVIVDYCLLLQRKDLLFSQMYDKLSENSVAKGVFLECLEPYIL
SDKLVGITPQVMKDLIVHFQDKKLMENVEALIVHMDITSLDIQQVVLMCWENRLYDAMIYVYNRGMNEFISPMEKLFRVIAPPLNAGKTL
TDEQVVMGNKLLVYISCCLAGRAYPLGDIPEDLVPLVKNQVFEFLIRLHSAEASPEEEIYPYIRTLLHFDTREFLNVLALTFEDFKNDKQ
AVEYQQRIVDILLKVMVENSDFTPSQVGCLFTFLARQLAKPDNTLFVNRTLFDQVLEFLCSPDDDSRHSERQQVLLELLQAGGIVQFEES
RLIRMAEKAEFYQICEFMYEREHQYDKIIDCYLRDPLREEEVFNYIHNILSIPGHSAEEKQSVWQKAMDHIEELVSLKPCKAAELVATHF
SGHIETVIKKLQNQVLLFKFLRSLLDPREGIHVNQELLQISPCITEQFIELLCQFNPTQVIETLQVLECYRLEETIQITQKYQLHEVTAY
LLEKKGDIHGAFLIMLERLQSKLQEVTHQGENTKEDPSLKDVEDTMVETIALCQRNSHNLNQQQREALWFPLLEAMMAPQKLSSSAIPHL
HSEALKSLTMQVLNSMAAFIALPSILQRILQDPVYGKGKLGEIQGLILGMLDTFNYEQTLLETTTSLLNQDLHWSLCNLRASVTRGLNPK
QDYCSICLQQYKRRQEMADEIIVFSCGHLYHSFCLQNKECTVEFEGQTRWTCYKCSSSNKVGKLSENSSEIKKGRITPSQVKMSPSYHQS
KGDPTAKKRFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKVQREPLLTLVKEIVPYNMAHNAE
HEACDLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQ
KQMAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFV
NAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVL
HNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLG
LGLNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQG
VAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARL
AAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLV

--------------------------------------------------------------
>98521_98521_4_VPS8-PSMD2_VPS8_chr3_184742177_ENST00000446204_PSMD2_chr3_184019324_ENST00000310118_length(transcript)=6445nt_BP=3911nt
CACGTGGGCCGGCGGTCCACGGCCGGAATGGCAGCAAGCTCAGAGATAATCATTCAGGTCTTCGTGAGCTAAGGCCAAACAAACAAAAAA
CACTTGCTTTGATGGACTGAATACTGTTATTAGAAGTAAATATGGAAAATGAACCAGACCATGAAAATGTGGAACAGAGCCTCTGTGCCA
AGACGAGCGAAGAAGAGCTGAATAAGTCTTTCAATCTAGAAGCTTCACTTTCAAAATTCTCTTACATAGATATGGACAAGGAACTGGAGT
TCAAAAATGATCTGATTGATGACAAGGAGTTTGATATTCCTCAAGTTGATACTCCTCCAACACTGGAAAGCATACTAAATGAGACTGATG
ATGAAGATGAGTCTTTTATTCTTGAGGATCCTACATTGTTAAACATTGATACTATTGATTCTCACTCCTATGATACTTCATCTGTGGCAA
GCTCAGATAGTGGTGACAGGACCAACTTAAAAAGGAAGAAGAAATTACCTGATTCTTTTTCACTTCATGGATCAGTTATGCGCCATTCAC
TTTTGAAGGGAATTTCTGCCCAGATAGTGTCTGCAGCTGACAAAGTAGATGCTGGCTTGCCTACAGCAATTGCAGTATCCAGTCTGATAG
CAGTGGGTACATCTCATGGATTGGCTTTAATATTTGATCAGAATCAAGCTTTGCGACTCTGTCTGGGTAGCACTAGTGTTGGAGGTCAGT
ATGGCGCTATCTCTGCCCTCAGTATCAACAATGATTGCTCAAGACTTCTTTGTGGCTTTGCTAAAGGACAGATCACCATGTGGGATTTGG
CCAGTGGAAAACTTCTAAGATCAATAACAGATGCTCATCCTCCAGGAACAGCAATATTGCATATCAAGTTTACAGATGATCCAACTCTTG
CAATTTGCAACGACAGCGGAGGCTCTGTTTTTGAATTGACATTTAAGAGAGTGATGGGAGTGAGAACCTGTGAATCTAGATGTCTGTTCA
GTGGTTCCAAGGGTGAAGTCTGCTGTATTGAGCCTCTGCATTCTAAGCCTGAGTTGAAAGATCATCCCATCACACAGTTTTCATTATTGG
CCATGGCATCCTTGACAAAAATACTGGTCATTGGATTGAAACCATCCTTGAAAGTATGGATGACTTTTCCCTATGGCCGGATGGATCCTT
CCAGTGTGCCACTGCTGGCCTGGCACTTTGTAGCAGTACAAAATTACGTGAATCCCATGCTTGCCTTCTGCAGAGGAGATGTTGTTCATT
TTCTATTGGTAAAGAGAGATGAATCTGGAGCAATACATGTTACTAAGCAAAAGCATCTTCACCTATACTATGACCTCATCAACTTTACCT
GGATAAATTCACGCACAGTTGTGCTCTTAGACAGCGTAGAGAAGTTGCATGTGATTGATCGGCAAACACAAGAGGAATTGGAGACAGTGG
AGATCTCAGAAGTTCAGCTGGTCTACAATAGCAGCCATTTCAAATCACTAGCCACTGGAGGAAATGTTAGCCAGGCACTGGCTTTGGTTG
GAGAGAAGGCTTGTTATCAATCCATCAGTAGCTATGGTGGTCAGATCTTTTATTTGGGGACAAAATCTGTTTATGTGATGATGCTGAGGA
GCTGGAGAGAGAGAGTGGATCATCTCCTGAAACAAGATTGTCTTACAGAAGCGTTGGCTCTTGCGTGGTCTTTCCATGAAGGAAAAGCAA
AAGCAGTAGTGGGATTATCAGGGGATGCCAGTAAGCGAAAGGCTATTGTTGCAGACCGGATGGTAGAAATCCTATTCCATTATGCAGATC
GAGCTCTGAAAAAGTGCCCAGACCAAGGAAAAATCCAAGTGATGGAGCAGCATTTTCAGGTAGTTCTCATGTGTTGGGAAAATCGTTTAT
ATGATGCTATGATCTATGTCTACAACAGAGGCATGAATGAATTTATTAGTCCAATGGAGAAACTTTTCAGAGTCATTGCTCCTCCTCTGA
ATGCAGGAAAAACACTAACAGATGAACAAGTTGTTATGGGCAATAAGCTCCTTGTATATATTAGCTGTTGTCTAGCAGGTCGTGCCTATC
CCCTTGGTGACATCCCTGAAGATCTGGTTCCCTTGGTTAAAAACCAGGTTTTTGAATTTCTAATTCGCCTGCATTCAGCAGAGGCTTCTC
CTGAGGAAGAAATCTATCCTTACATTCGGACTTTGCTACATTTTGACACAAGAGAATTTCTAAATGTATTGGCACTGACTTTTGAAGATT
TTAAAAATGACAAGCAAGCTGTGGAATATCAACAGCGAATTGTGGATATTTTGTTGAAAGTTATGGTGGAGAATTCAGACTTTACCCCCT
CACAAGTAGGATGTCTCTTTACCTTCCTTGCTCGGCAGCTTGCAAAGCCTGACAACACCTTGTTTGTAAACAGAACACTTTTTGATCAGG
TCCTTGAATTCCTTTGTAGTCCTGACGATGACTCCCGACACTCTGAAAGACAGCAGGTCCTTTTAGAATTGCTGCAGGCTGGAGGCATAG
TTCAATTTGAAGAGAGTCGACTCATCCGGATGGCAGAAAAAGCTGAGTTCTATCAAATTTGTGAATTTATGTATGAAAGAGAACACCAAT
ATGATAAAATTATTGATTGCTACTTACGTGACCCTCTGCGAGAGGAAGAAGTCTTTAATTACATTCACAATATCTTATCCATTCCCGGAC
ACAGTGCAGAGGAGAAGCAGTCTGTATGGCAGAAAGCAATGGATCATATTGAGGAACTCGTGTCCCTGAAGCCTTGTAAAGCTGCGGAGC
TGGTTGCCACCCACTTTTCTGGACATATTGAAACGGTCATTAAAAAACTTCAGAACCAGGTTTTGCTTTTCAAATTTTTGAGGAGTCTTC
TTGACCCAAGGGAAGGTATTCATGTAAATCAAGAATTACTGCAAATATCTCCTTGTATCACAGAGCAGTTCATTGAGCTGTTGTGTCAGT
TCAACCCAACCCAAGTTATAGAGACTCTGCAAGTCCTTGAGTGCTACCGTCTGGAAGAAACTATTCAGATTACTCAGAAGTATCAACTTC
ATGAAGTCACCGCTTATCTATTGGAAAAGAAAGGAGATATTCATGGTGCCTTCCTAATAATGTTAGAGAGACTACAAAGCAAACTTCAAG
AGGTAACACATCAAGGTGAAAATACCAAAGAGGATCCCTCATTGAAGGATGTTGAAGATACTATGGTGGAGACCATTGCTCTTTGCCAGA
GAAATTCACATAATTTGAACCAGCAGCAACGTGAGGCACTTTGGTTTCCGTTATTGGAGGCAATGATGGCCCCTCAGAAGCTGTCCAGTT
CAGCCATTCCTCATCTACACTCTGAAGCTCTGAAGTCTTTGACCATGCAAGTTTTAAATAGCATGGCAGCATTTATTGCCCTTCCATCAA
TCTTGCAAAGAATCTTACAGGATCCAGTTTATGGAAAAGGAAAACTTGGAGAAATCCAGGGACTTATCTTGGGAATGTTAGATACCTTTA
ACTATGAACAAACCCTGCTGGAAACAACAACCAGCCTTCTAAACCAAGATCTCCATTGGTCATTGTGTAACCTGAGAGCTTCGGTCACCA
GAGGACTGAATCCCAAACAAGATTACTGCTCTATATGTTTGCAGCAGTACAAGAGACGCCAAGAAATGGCTGATGAAATAATTGTCTTTA
GCTGTGGCCATTTGTATCACTCATTCTGCCTACAAAACAAAGAATGCACTGTGGAATTTGAGGGCCAAACAAGATGGACATGCTACAAAT
GCAGTTCAAGTAACAAAGTAGGAAAACTCAGTGAAAATTCATCTGAAATTAAAAAGGGAAGGATAACCCCATCACAGGTAAAAATGTCTC
CATCGTATCATCAGTCCAAAGGGGATCCCACTGCTAAAAAGCGTTTTGCTGCTGACATCATCTCCGTTTTGGCCATGACCATGAGTGGGG
AGCGTGAGTGCCTCAAGTATCGGCTAGTGGGCTCCCAGGAGGAATTGGCATCATGGGGTCATGAGTATGTCAGGCATCTGGCAGGAGAAG
TGGCTAAGGAGTGGCAGGAGCTGGATGACGCAGAGAAGGTCCAGCGGGAGCCTCTGCTCACTCTGGTGAAGGAAATCGTCCCCTATAACA
TGGCCCACAATGCAGAGCATGAGGCTTGCGACCTGCTTATGGAAATTGAGCAGGTGGACATGCTGGAGAAGGACATTGATGAAAATGCAT
ATGCAAAGGTCTGCCTTTATCTCACCAGTTGTGTGAATTACGTGCCTGAGCCTGAGAACTCAGCCCTACTGCGTTGTGCCCTGGGTGTGT
TCCGAAAGTTTAGCCGCTTCCCTGAAGCTCTGAGATTGGCATTGATGCTCAATGACATGGAGTTGGTAGAAGACATCTTCACCTCCTGCA
AGGATGTGGTAGTACAGAAACAGATGGCATTCATGCTAGGCCGGCATGGGGTGTTCCTGGAGCTGAGTGAAGATGTCGAGGAGTATGAGG
ACCTGACAGAGATCATGTCCAATGTACAGCTCAACAGCAACTTCTTGGCCTTAGCTCGGGAGCTGGACATCATGGAGCCCAAGGTGCCTG
ATGACATCTACAAAACCCACCTAGAGAACAACAGGTTTGGGGGCAGTGGCTCTCAGGTGGACTCTGCCCGCATGAACCTGGCCTCCTCTT
TTGTGAATGGCTTTGTGAATGCAGCTTTTGGCCAAGACAAGCTGCTAACAGATGATGGCAACAAATGGCTTTACAAGAACAAGGACCACG
GAATGTTGAGTGCAGCTGCATCTCTTGGGATGATTCTGCTGTGGGATGTGGATGGTGGCCTCACCCAGATTGACAAGTACCTGTACTCCT
CTGAGGACTACATTAAGTCAGGAGCTCTTCTTGCCTGTGGCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGC
TCTCAGACTATGTTCTCCACAACAGCAACACCATGAGACTTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAG
ATGTCCTAACACTGCTGCTGCCTGTGATGGGAGATTCAAAGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAG
CAGTAGGGTCCTGCAATGGAGATGTAACTTCCACTATCCTTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTC
GTTGGCTTCCTCTTGGACTGGGTCTCAACCACCTGGGGAAGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGC
CATTCCGCAGTTTTGCCAACACACTGGTGGATGTGTGTGCATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTT
GTAGCGAACACTTTGACTCCAAAGAGAAGGAGGAAGACAAAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACA
TGGGAGCACATCAGGGAGTGGCTGTTCTGGGGATTGCCCTTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTG
GCCACTTGCTGAGATATGGGGAGCCTACACTCCGGAGGGCTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACA
TCCTGGATACCCTAAGCAAATTCTCTCATGATGCTGATCCAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTA
CCAATAATGCCCGTCTGGCTGCAATGCTGCGCCAGTTAGCTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCAC
AGGGCCTGACACATTTAGGGAAGGGCACCCTTACCCTCTGCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGAC
TGCTCACTGTGCTTGTCTCTTTCCTGGATGTTCGAAACATTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGC
AGCCCCGAATGCTGGTTACGTTTGATGAGGAGCTGCGGCCATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGG
CTGGCAAGCCGAAGACTATCACAGGGTTCCAGACGCATACAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGG
AGTTTCTTCCTGTTACCCCCATTCTGGAAGGTTTTGTTATCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTG
AACTGCAGCTGATGTTATCAGCAGGCCATGCATCCTGCTGCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCT

>98521_98521_4_VPS8-PSMD2_VPS8_chr3_184742177_ENST00000446204_PSMD2_chr3_184019324_ENST00000310118_length(amino acids)=2055AA_BP=1266
MLLEVNMENEPDHENVEQSLCAKTSEEELNKSFNLEASLSKFSYIDMDKELEFKNDLIDDKEFDIPQVDTPPTLESILNETDDEDESFIL
EDPTLLNIDTIDSHSYDTSSVASSDSGDRTNLKRKKKLPDSFSLHGSVMRHSLLKGISAQIVSAADKVDAGLPTAIAVSSLIAVGTSHGL
ALIFDQNQALRLCLGSTSVGGQYGAISALSINNDCSRLLCGFAKGQITMWDLASGKLLRSITDAHPPGTAILHIKFTDDPTLAICNDSGG
SVFELTFKRVMGVRTCESRCLFSGSKGEVCCIEPLHSKPELKDHPITQFSLLAMASLTKILVIGLKPSLKVWMTFPYGRMDPSSVPLLAW
HFVAVQNYVNPMLAFCRGDVVHFLLVKRDESGAIHVTKQKHLHLYYDLINFTWINSRTVVLLDSVEKLHVIDRQTQEELETVEISEVQLV
YNSSHFKSLATGGNVSQALALVGEKACYQSISSYGGQIFYLGTKSVYVMMLRSWRERVDHLLKQDCLTEALALAWSFHEGKAKAVVGLSG
DASKRKAIVADRMVEILFHYADRALKKCPDQGKIQVMEQHFQVVLMCWENRLYDAMIYVYNRGMNEFISPMEKLFRVIAPPLNAGKTLTD
EQVVMGNKLLVYISCCLAGRAYPLGDIPEDLVPLVKNQVFEFLIRLHSAEASPEEEIYPYIRTLLHFDTREFLNVLALTFEDFKNDKQAV
EYQQRIVDILLKVMVENSDFTPSQVGCLFTFLARQLAKPDNTLFVNRTLFDQVLEFLCSPDDDSRHSERQQVLLELLQAGGIVQFEESRL
IRMAEKAEFYQICEFMYEREHQYDKIIDCYLRDPLREEEVFNYIHNILSIPGHSAEEKQSVWQKAMDHIEELVSLKPCKAAELVATHFSG
HIETVIKKLQNQVLLFKFLRSLLDPREGIHVNQELLQISPCITEQFIELLCQFNPTQVIETLQVLECYRLEETIQITQKYQLHEVTAYLL
EKKGDIHGAFLIMLERLQSKLQEVTHQGENTKEDPSLKDVEDTMVETIALCQRNSHNLNQQQREALWFPLLEAMMAPQKLSSSAIPHLHS
EALKSLTMQVLNSMAAFIALPSILQRILQDPVYGKGKLGEIQGLILGMLDTFNYEQTLLETTTSLLNQDLHWSLCNLRASVTRGLNPKQD
YCSICLQQYKRRQEMADEIIVFSCGHLYHSFCLQNKECTVEFEGQTRWTCYKCSSSNKVGKLSENSSEIKKGRITPSQVKMSPSYHQSKG
DPTAKKRFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKVQREPLLTLVKEIVPYNMAHNAEHE
ACDLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQKQ
MAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNA
AFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHN
SNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLG
LNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVA
VLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAA
MLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for VPS8-PSMD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VPS8-PSMD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VPS8-PSMD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource