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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VRK3-CBLC (FusionGDB2 ID:98543)

Fusion Gene Summary for VRK3-CBLC

check button Fusion gene summary
Fusion gene informationFusion gene name: VRK3-CBLC
Fusion gene ID: 98543
HgeneTgene
Gene symbol

VRK3

CBLC

Gene ID

51231

23624

Gene nameVRK serine/threonine kinase 3Cbl proto-oncogene C
Synonyms-CBL-3|CBL-SL|RNF57
Cytomap

19q13.33

19q13.32

Type of geneprotein-codingprotein-coding
Descriptioninactive serine/threonine-protein kinase VRK3serine/threonine-protein kinase VRK3serine/threonine-protein pseudokinase VRK3vaccinia related kinase 3E3 ubiquitin-protein ligase CBL-CCas-Br-M (murine) ecotropic retroviral transforming sequence cCas-Br-M (murine) ectropic retroviral transforming sequence cCbl proto-oncogene C, E3 ubiquitin protein ligaseCbl proto-oncogene, E3 ubiquitin protein ligas
Modification date2020031320200313
UniProtAcc.

Q9ULV8

Ensembl transtripts involved in fusion geneENST00000424804, ENST00000443401, 
ENST00000593919, ENST00000594092, 
ENST00000594948, ENST00000599538, 
ENST00000601341, ENST00000601912, 
ENST00000316763, ENST00000377011, 
ENST00000270279, ENST00000341505, 
Fusion gene scores* DoF score7 X 6 X 4=1684 X 7 X 2=56
# samples 97
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/56*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VRK3 [Title/Abstract] AND CBLC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVRK3(50504046)-CBLC(45296730), # samples:1
VRK3(50504047)-CBLC(45296731), # samples:1
Anticipated loss of major functional domain due to fusion event.VRK3-CBLC seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
VRK3-CBLC seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
VRK3-CBLC seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCBLC

GO:0006511

ubiquitin-dependent protein catabolic process

14661060

TgeneCBLC

GO:0007175

negative regulation of epidermal growth factor-activated receptor activity

10362357

TgeneCBLC

GO:0016567

protein ubiquitination

14661060

TgeneCBLC

GO:0042059

negative regulation of epidermal growth factor receptor signaling pathway

10362357

TgeneCBLC

GO:0043407

negative regulation of MAP kinase activity

10362357


check buttonFusion gene breakpoints across VRK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CBLC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-B5-A1N2-01AVRK3chr19

50504047

-CBLCchr19

45296731

+
ChimerDB4UCECTCGA-B5-A1N2VRK3chr19

50504046

-CBLCchr19

45296730

+


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Fusion Gene ORF analysis for VRK3-CBLC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000424804ENST00000270279VRK3chr19

50504047

-CBLCchr19

45296731

+
5UTR-3CDSENST00000424804ENST00000270279VRK3chr19

50504046

-CBLCchr19

45296730

+
5UTR-3CDSENST00000424804ENST00000341505VRK3chr19

50504047

-CBLCchr19

45296731

+
5UTR-3CDSENST00000424804ENST00000341505VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000443401ENST00000270279VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000443401ENST00000270279VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000443401ENST00000341505VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000443401ENST00000341505VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000593919ENST00000270279VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000593919ENST00000270279VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000593919ENST00000341505VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000593919ENST00000341505VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000594092ENST00000270279VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000594092ENST00000270279VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000594092ENST00000341505VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000594092ENST00000341505VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000594948ENST00000270279VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000594948ENST00000270279VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000594948ENST00000341505VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000594948ENST00000341505VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000599538ENST00000270279VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000599538ENST00000270279VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000599538ENST00000341505VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000599538ENST00000341505VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000601341ENST00000270279VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000601341ENST00000270279VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000601341ENST00000341505VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000601341ENST00000341505VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000601912ENST00000270279VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000601912ENST00000270279VRK3chr19

50504046

-CBLCchr19

45296730

+
Frame-shiftENST00000601912ENST00000341505VRK3chr19

50504047

-CBLCchr19

45296731

+
Frame-shiftENST00000601912ENST00000341505VRK3chr19

50504046

-CBLCchr19

45296730

+
In-frameENST00000316763ENST00000270279VRK3chr19

50504047

-CBLCchr19

45296731

+
In-frameENST00000316763ENST00000270279VRK3chr19

50504046

-CBLCchr19

45296730

+
In-frameENST00000316763ENST00000341505VRK3chr19

50504047

-CBLCchr19

45296731

+
In-frameENST00000316763ENST00000341505VRK3chr19

50504046

-CBLCchr19

45296730

+
In-frameENST00000377011ENST00000270279VRK3chr19

50504047

-CBLCchr19

45296731

+
In-frameENST00000377011ENST00000270279VRK3chr19

50504046

-CBLCchr19

45296730

+
In-frameENST00000377011ENST00000341505VRK3chr19

50504047

-CBLCchr19

45296731

+
In-frameENST00000377011ENST00000341505VRK3chr19

50504046

-CBLCchr19

45296730

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000316763VRK3chr1950504046-ENST00000341505CBLCchr1945296730+11757961841083299
ENST00000316763VRK3chr1950504046-ENST00000270279CBLCchr1945296730+11757961841083299
ENST00000377011VRK3chr1950504046-ENST00000341505CBLCchr1945296730+1011632170919249
ENST00000377011VRK3chr1950504046-ENST00000270279CBLCchr1945296730+1011632170919249
ENST00000316763VRK3chr1950504047-ENST00000341505CBLCchr1945296731+11757961841083299
ENST00000316763VRK3chr1950504047-ENST00000270279CBLCchr1945296731+11757961841083299
ENST00000377011VRK3chr1950504047-ENST00000341505CBLCchr1945296731+1011632170919249
ENST00000377011VRK3chr1950504047-ENST00000270279CBLCchr1945296731+1011632170919249

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000316763ENST00000341505VRK3chr1950504046-CBLCchr1945296730+0.150187690.8498123
ENST00000316763ENST00000270279VRK3chr1950504046-CBLCchr1945296730+0.150187690.8498123
ENST00000377011ENST00000341505VRK3chr1950504046-CBLCchr1945296730+0.185935450.81406456
ENST00000377011ENST00000270279VRK3chr1950504046-CBLCchr1945296730+0.185935450.81406456
ENST00000316763ENST00000341505VRK3chr1950504047-CBLCchr1945296731+0.150187690.8498123
ENST00000316763ENST00000270279VRK3chr1950504047-CBLCchr1945296731+0.150187690.8498123
ENST00000377011ENST00000341505VRK3chr1950504047-CBLCchr1945296731+0.185935450.81406456
ENST00000377011ENST00000270279VRK3chr1950504047-CBLCchr1945296731+0.185935450.81406456

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Fusion Genomic Features for VRK3-CBLC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
VRK3chr1950504046-CBLCchr1945296730+0.0065198180.9934802
VRK3chr1950504046-CBLCchr1945296730+0.0065198180.9934802
VRK3chr1950504046-CBLCchr1945296730+0.0065198180.9934802
VRK3chr1950504046-CBLCchr1945296730+0.0065198180.9934802

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for VRK3-CBLC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:50504046/chr19:45296730)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CBLC

Q9ULV8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. {ECO:0000269|PubMed:10362357, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:18753381, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:23145173}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVRK3chr19:50504046chr19:45296730ENST00000316763-61549_64204573.3333333333334MotifNuclear localization signal
HgeneVRK3chr19:50504046chr19:45296730ENST00000377011-51449_64154519.6666666666666MotifNuclear localization signal
HgeneVRK3chr19:50504046chr19:45296730ENST00000594092-61349_64204413.0MotifNuclear localization signal
HgeneVRK3chr19:50504046chr19:45296730ENST00000594948-61449_64204475.0MotifNuclear localization signal
HgeneVRK3chr19:50504046chr19:45296730ENST00000599538-61549_64204315.3333333333333MotifNuclear localization signal
HgeneVRK3chr19:50504046chr19:45296730ENST00000601341-51349_64154425.0MotifNuclear localization signal
HgeneVRK3chr19:50504047chr19:45296731ENST00000316763-61549_64204573.3333333333334MotifNuclear localization signal
HgeneVRK3chr19:50504047chr19:45296731ENST00000377011-51449_64154519.6666666666666MotifNuclear localization signal
HgeneVRK3chr19:50504047chr19:45296731ENST00000594092-61349_64204413.0MotifNuclear localization signal
HgeneVRK3chr19:50504047chr19:45296731ENST00000594948-61449_64204475.0MotifNuclear localization signal
HgeneVRK3chr19:50504047chr19:45296731ENST00000599538-61549_64204315.3333333333333MotifNuclear localization signal
HgeneVRK3chr19:50504047chr19:45296731ENST00000601341-51349_64154425.0MotifNuclear localization signal
TgeneCBLCchr19:50504046chr19:45296730ENST00000341505510351_390333318.3333333333333Zinc fingerRING-type
TgeneCBLCchr19:50504047chr19:45296731ENST00000341505510351_390333318.3333333333333Zinc fingerRING-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVRK3chr19:50504046chr19:45296730ENST00000316763-615166_457204573.3333333333334DomainProtein kinase
HgeneVRK3chr19:50504046chr19:45296730ENST00000377011-514166_457154519.6666666666666DomainProtein kinase
HgeneVRK3chr19:50504046chr19:45296730ENST00000594092-613166_457204413.0DomainProtein kinase
HgeneVRK3chr19:50504046chr19:45296730ENST00000594948-614166_457204475.0DomainProtein kinase
HgeneVRK3chr19:50504046chr19:45296730ENST00000599538-615166_457204315.3333333333333DomainProtein kinase
HgeneVRK3chr19:50504046chr19:45296730ENST00000601341-513166_457154425.0DomainProtein kinase
HgeneVRK3chr19:50504047chr19:45296731ENST00000316763-615166_457204573.3333333333334DomainProtein kinase
HgeneVRK3chr19:50504047chr19:45296731ENST00000377011-514166_457154519.6666666666666DomainProtein kinase
HgeneVRK3chr19:50504047chr19:45296731ENST00000594092-613166_457204413.0DomainProtein kinase
HgeneVRK3chr19:50504047chr19:45296731ENST00000594948-614166_457204475.0DomainProtein kinase
HgeneVRK3chr19:50504047chr19:45296731ENST00000599538-615166_457204315.3333333333333DomainProtein kinase
HgeneVRK3chr19:50504047chr19:45296731ENST00000601341-513166_457154425.0DomainProtein kinase
TgeneCBLCchr19:50504046chr19:45296730ENST00000270279611199_210379364.3333333333333Calcium binding.
TgeneCBLCchr19:50504046chr19:45296730ENST00000341505510199_210333318.3333333333333Calcium binding.
TgeneCBLCchr19:50504047chr19:45296731ENST00000270279611199_210379364.3333333333333Calcium binding.
TgeneCBLCchr19:50504047chr19:45296731ENST00000341505510199_210333318.3333333333333Calcium binding.
TgeneCBLCchr19:50504046chr19:45296730ENST000002702796117_321379364.3333333333333DomainCbl-PTB
TgeneCBLCchr19:50504046chr19:45296730ENST000003415055107_321333318.3333333333333DomainCbl-PTB
TgeneCBLCchr19:50504047chr19:45296731ENST000002702796117_321379364.3333333333333DomainCbl-PTB
TgeneCBLCchr19:50504047chr19:45296731ENST000003415055107_321333318.3333333333333DomainCbl-PTB
TgeneCBLCchr19:50504046chr19:45296730ENST00000270279611146_218379364.3333333333333RegionNote=EF-hand-like
TgeneCBLCchr19:50504046chr19:45296730ENST00000270279611219_321379364.3333333333333RegionNote=SH2-like
TgeneCBLCchr19:50504046chr19:45296730ENST00000270279611322_350379364.3333333333333RegionNote=Linker
TgeneCBLCchr19:50504046chr19:45296730ENST000002702796117_145379364.3333333333333RegionNote=4H
TgeneCBLCchr19:50504046chr19:45296730ENST00000341505510146_218333318.3333333333333RegionNote=EF-hand-like
TgeneCBLCchr19:50504046chr19:45296730ENST00000341505510219_321333318.3333333333333RegionNote=SH2-like
TgeneCBLCchr19:50504046chr19:45296730ENST00000341505510322_350333318.3333333333333RegionNote=Linker
TgeneCBLCchr19:50504046chr19:45296730ENST000003415055107_145333318.3333333333333RegionNote=4H
TgeneCBLCchr19:50504047chr19:45296731ENST00000270279611146_218379364.3333333333333RegionNote=EF-hand-like
TgeneCBLCchr19:50504047chr19:45296731ENST00000270279611219_321379364.3333333333333RegionNote=SH2-like
TgeneCBLCchr19:50504047chr19:45296731ENST00000270279611322_350379364.3333333333333RegionNote=Linker
TgeneCBLCchr19:50504047chr19:45296731ENST000002702796117_145379364.3333333333333RegionNote=4H
TgeneCBLCchr19:50504047chr19:45296731ENST00000341505510146_218333318.3333333333333RegionNote=EF-hand-like
TgeneCBLCchr19:50504047chr19:45296731ENST00000341505510219_321333318.3333333333333RegionNote=SH2-like
TgeneCBLCchr19:50504047chr19:45296731ENST00000341505510322_350333318.3333333333333RegionNote=Linker
TgeneCBLCchr19:50504047chr19:45296731ENST000003415055107_145333318.3333333333333RegionNote=4H
TgeneCBLCchr19:50504046chr19:45296730ENST00000270279611351_390379364.3333333333333Zinc fingerRING-type
TgeneCBLCchr19:50504047chr19:45296731ENST00000270279611351_390379364.3333333333333Zinc fingerRING-type


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Fusion Gene Sequence for VRK3-CBLC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98543_98543_1_VRK3-CBLC_VRK3_chr19_50504046_ENST00000316763_CBLC_chr19_45296730_ENST00000270279_length(transcript)=1175nt_BP=796nt
GCTCTCCGCCCAGCGGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCC
AGAATCCCACCCCAGTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATA
AAGCATGATCTCCTTCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGA
GGAGCATGTAGGGTCCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCAAAGAGAGGGCTGAACTCCAGTTTTGAAACCTC
TCCTAAGAAAGTGAAATGGTCCAGCACCGTCACCTCTCCCCGATTATCCCTCTTCTCAGATGGTGACAGTTCTGAGTCTGAAGATACTCT
GAGTTCCTCTGAGAGATCCAAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGAAGAGCCCTCAGGTGAC
CAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCCGAGTGACCACCTCACT
TGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCAGGGACAACCAGGGCAT
TCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAACTGCACTCGGACAGCCA
GACCTGCCCCTTCTGCCGCTGCGAGATCAAGGGCTGGGAGGCCGTGAGTATCTACCAGTTCCACGGTCAGGCTACTGCTGAGGACTCAGG
GAACAGCAGTGACCAGGAAGGCAGGGAGTTGGAGCTGGGGCAGGTGCCCCTTTCGGCTCCTCCATTGCCCCCACGGCCAGATCTGCCCCC
CAGGAAGCCCAGAAATGCCCAGCCGAAAGTGAGACTCCTAAAGGGGAACTCCCCTCCAGCTGCGCTGGGACCCCAGGACCCTGCCCCGGC
CTGAAGGCCAGGGCACCCAGATGTGCTGCTCAAGGGAGCCCCAAGGGCTGGAAGGGGGTTGTGAAACCGAAATAAACTGCCAAGCCTGGT

>98543_98543_1_VRK3-CBLC_VRK3_chr19_50504046_ENST00000316763_CBLC_chr19_45296730_ENST00000270279_length(amino acids)=299AA_BP=204
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLS
SSERSKGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL
YEAAPTSTLTCDSGPQKQKFSLKLHSDSQTCPFCRCEIKGWEAVSIYQFHGQATAEDSGNSSDQEGRELELGQVPLSAPPLPPRPDLPPR

--------------------------------------------------------------
>98543_98543_2_VRK3-CBLC_VRK3_chr19_50504046_ENST00000316763_CBLC_chr19_45296730_ENST00000341505_length(transcript)=1175nt_BP=796nt
GCTCTCCGCCCAGCGGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCC
AGAATCCCACCCCAGTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATA
AAGCATGATCTCCTTCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGA
GGAGCATGTAGGGTCCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCAAAGAGAGGGCTGAACTCCAGTTTTGAAACCTC
TCCTAAGAAAGTGAAATGGTCCAGCACCGTCACCTCTCCCCGATTATCCCTCTTCTCAGATGGTGACAGTTCTGAGTCTGAAGATACTCT
GAGTTCCTCTGAGAGATCCAAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGAAGAGCCCTCAGGTGAC
CAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCCGAGTGACCACCTCACT
TGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCAGGGACAACCAGGGCAT
TCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAACTGCACTCGGACAGCCA
GACCTGCCCCTTCTGCCGCTGCGAGATCAAGGGCTGGGAGGCCGTGAGTATCTACCAGTTCCACGGTCAGGCTACTGCTGAGGACTCAGG
GAACAGCAGTGACCAGGAAGGCAGGGAGTTGGAGCTGGGGCAGGTGCCCCTTTCGGCTCCTCCATTGCCCCCACGGCCAGATCTGCCCCC
CAGGAAGCCCAGAAATGCCCAGCCGAAAGTGAGACTCCTAAAGGGGAACTCCCCTCCAGCTGCGCTGGGACCCCAGGACCCTGCCCCGGC
CTGAAGGCCAGGGCACCCAGATGTGCTGCTCAAGGGAGCCCCAAGGGCTGGAAGGGGGTTGTGAAACCGAAATAAACTGCCAAGCCTGGT

>98543_98543_2_VRK3-CBLC_VRK3_chr19_50504046_ENST00000316763_CBLC_chr19_45296730_ENST00000341505_length(amino acids)=299AA_BP=204
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLS
SSERSKGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL
YEAAPTSTLTCDSGPQKQKFSLKLHSDSQTCPFCRCEIKGWEAVSIYQFHGQATAEDSGNSSDQEGRELELGQVPLSAPPLPPRPDLPPR

--------------------------------------------------------------
>98543_98543_3_VRK3-CBLC_VRK3_chr19_50504046_ENST00000377011_CBLC_chr19_45296730_ENST00000270279_length(transcript)=1011nt_BP=632nt
GGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCCAGAATCCCACCCCA
GTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATAAAGCATGATCTCCT
TCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGAGGAGCATGTAGGGT
CCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGA
AGAGCCCTCAGGTGACCAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCC
GAGTGACCACCTCACTTGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCA
GGGACAACCAGGGCATTCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAAC
TGCACTCGGACAGCCAGACCTGCCCCTTCTGCCGCTGCGAGATCAAGGGCTGGGAGGCCGTGAGTATCTACCAGTTCCACGGTCAGGCTA
CTGCTGAGGACTCAGGGAACAGCAGTGACCAGGAAGGCAGGGAGTTGGAGCTGGGGCAGGTGCCCCTTTCGGCTCCTCCATTGCCCCCAC
GGCCAGATCTGCCCCCCAGGAAGCCCAGAAATGCCCAGCCGAAAGTGAGACTCCTAAAGGGGAACTCCCCTCCAGCTGCGCTGGGACCCC
AGGACCCTGCCCCGGCCTGAAGGCCAGGGCACCCAGATGTGCTGCTCAAGGGAGCCCCAAGGGCTGGAAGGGGGTTGTGAAACCGAAATA

>98543_98543_3_VRK3-CBLC_VRK3_chr19_50504046_ENST00000377011_CBLC_chr19_45296730_ENST00000270279_length(amino acids)=249AA_BP=154
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTL
KRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLHSDSQTCPFCRCEIKGWEAVSIYQFH

--------------------------------------------------------------
>98543_98543_4_VRK3-CBLC_VRK3_chr19_50504046_ENST00000377011_CBLC_chr19_45296730_ENST00000341505_length(transcript)=1011nt_BP=632nt
GGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCCAGAATCCCACCCCA
GTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATAAAGCATGATCTCCT
TCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGAGGAGCATGTAGGGT
CCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGA
AGAGCCCTCAGGTGACCAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCC
GAGTGACCACCTCACTTGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCA
GGGACAACCAGGGCATTCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAAC
TGCACTCGGACAGCCAGACCTGCCCCTTCTGCCGCTGCGAGATCAAGGGCTGGGAGGCCGTGAGTATCTACCAGTTCCACGGTCAGGCTA
CTGCTGAGGACTCAGGGAACAGCAGTGACCAGGAAGGCAGGGAGTTGGAGCTGGGGCAGGTGCCCCTTTCGGCTCCTCCATTGCCCCCAC
GGCCAGATCTGCCCCCCAGGAAGCCCAGAAATGCCCAGCCGAAAGTGAGACTCCTAAAGGGGAACTCCCCTCCAGCTGCGCTGGGACCCC
AGGACCCTGCCCCGGCCTGAAGGCCAGGGCACCCAGATGTGCTGCTCAAGGGAGCCCCAAGGGCTGGAAGGGGGTTGTGAAACCGAAATA

>98543_98543_4_VRK3-CBLC_VRK3_chr19_50504046_ENST00000377011_CBLC_chr19_45296730_ENST00000341505_length(amino acids)=249AA_BP=154
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTL
KRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLHSDSQTCPFCRCEIKGWEAVSIYQFH

--------------------------------------------------------------
>98543_98543_5_VRK3-CBLC_VRK3_chr19_50504047_ENST00000316763_CBLC_chr19_45296731_ENST00000270279_length(transcript)=1175nt_BP=796nt
GCTCTCCGCCCAGCGGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCC
AGAATCCCACCCCAGTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATA
AAGCATGATCTCCTTCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGA
GGAGCATGTAGGGTCCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCAAAGAGAGGGCTGAACTCCAGTTTTGAAACCTC
TCCTAAGAAAGTGAAATGGTCCAGCACCGTCACCTCTCCCCGATTATCCCTCTTCTCAGATGGTGACAGTTCTGAGTCTGAAGATACTCT
GAGTTCCTCTGAGAGATCCAAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGAAGAGCCCTCAGGTGAC
CAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCCGAGTGACCACCTCACT
TGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCAGGGACAACCAGGGCAT
TCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAACTGCACTCGGACAGCCA
GACCTGCCCCTTCTGCCGCTGCGAGATCAAGGGCTGGGAGGCCGTGAGTATCTACCAGTTCCACGGTCAGGCTACTGCTGAGGACTCAGG
GAACAGCAGTGACCAGGAAGGCAGGGAGTTGGAGCTGGGGCAGGTGCCCCTTTCGGCTCCTCCATTGCCCCCACGGCCAGATCTGCCCCC
CAGGAAGCCCAGAAATGCCCAGCCGAAAGTGAGACTCCTAAAGGGGAACTCCCCTCCAGCTGCGCTGGGACCCCAGGACCCTGCCCCGGC
CTGAAGGCCAGGGCACCCAGATGTGCTGCTCAAGGGAGCCCCAAGGGCTGGAAGGGGGTTGTGAAACCGAAATAAACTGCCAAGCCTGGT

>98543_98543_5_VRK3-CBLC_VRK3_chr19_50504047_ENST00000316763_CBLC_chr19_45296731_ENST00000270279_length(amino acids)=299AA_BP=204
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLS
SSERSKGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL
YEAAPTSTLTCDSGPQKQKFSLKLHSDSQTCPFCRCEIKGWEAVSIYQFHGQATAEDSGNSSDQEGRELELGQVPLSAPPLPPRPDLPPR

--------------------------------------------------------------
>98543_98543_6_VRK3-CBLC_VRK3_chr19_50504047_ENST00000316763_CBLC_chr19_45296731_ENST00000341505_length(transcript)=1175nt_BP=796nt
GCTCTCCGCCCAGCGGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCC
AGAATCCCACCCCAGTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATA
AAGCATGATCTCCTTCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGA
GGAGCATGTAGGGTCCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCAAAGAGAGGGCTGAACTCCAGTTTTGAAACCTC
TCCTAAGAAAGTGAAATGGTCCAGCACCGTCACCTCTCCCCGATTATCCCTCTTCTCAGATGGTGACAGTTCTGAGTCTGAAGATACTCT
GAGTTCCTCTGAGAGATCCAAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGAAGAGCCCTCAGGTGAC
CAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCCGAGTGACCACCTCACT
TGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCAGGGACAACCAGGGCAT
TCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAACTGCACTCGGACAGCCA
GACCTGCCCCTTCTGCCGCTGCGAGATCAAGGGCTGGGAGGCCGTGAGTATCTACCAGTTCCACGGTCAGGCTACTGCTGAGGACTCAGG
GAACAGCAGTGACCAGGAAGGCAGGGAGTTGGAGCTGGGGCAGGTGCCCCTTTCGGCTCCTCCATTGCCCCCACGGCCAGATCTGCCCCC
CAGGAAGCCCAGAAATGCCCAGCCGAAAGTGAGACTCCTAAAGGGGAACTCCCCTCCAGCTGCGCTGGGACCCCAGGACCCTGCCCCGGC
CTGAAGGCCAGGGCACCCAGATGTGCTGCTCAAGGGAGCCCCAAGGGCTGGAAGGGGGTTGTGAAACCGAAATAAACTGCCAAGCCTGGT

>98543_98543_6_VRK3-CBLC_VRK3_chr19_50504047_ENST00000316763_CBLC_chr19_45296731_ENST00000341505_length(amino acids)=299AA_BP=204
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLS
SSERSKGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL
YEAAPTSTLTCDSGPQKQKFSLKLHSDSQTCPFCRCEIKGWEAVSIYQFHGQATAEDSGNSSDQEGRELELGQVPLSAPPLPPRPDLPPR

--------------------------------------------------------------
>98543_98543_7_VRK3-CBLC_VRK3_chr19_50504047_ENST00000377011_CBLC_chr19_45296731_ENST00000270279_length(transcript)=1011nt_BP=632nt
GGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCCAGAATCCCACCCCA
GTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATAAAGCATGATCTCCT
TCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGAGGAGCATGTAGGGT
CCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGA
AGAGCCCTCAGGTGACCAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCC
GAGTGACCACCTCACTTGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCA
GGGACAACCAGGGCATTCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAAC
TGCACTCGGACAGCCAGACCTGCCCCTTCTGCCGCTGCGAGATCAAGGGCTGGGAGGCCGTGAGTATCTACCAGTTCCACGGTCAGGCTA
CTGCTGAGGACTCAGGGAACAGCAGTGACCAGGAAGGCAGGGAGTTGGAGCTGGGGCAGGTGCCCCTTTCGGCTCCTCCATTGCCCCCAC
GGCCAGATCTGCCCCCCAGGAAGCCCAGAAATGCCCAGCCGAAAGTGAGACTCCTAAAGGGGAACTCCCCTCCAGCTGCGCTGGGACCCC
AGGACCCTGCCCCGGCCTGAAGGCCAGGGCACCCAGATGTGCTGCTCAAGGGAGCCCCAAGGGCTGGAAGGGGGTTGTGAAACCGAAATA

>98543_98543_7_VRK3-CBLC_VRK3_chr19_50504047_ENST00000377011_CBLC_chr19_45296731_ENST00000270279_length(amino acids)=249AA_BP=154
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTL
KRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLHSDSQTCPFCRCEIKGWEAVSIYQFH

--------------------------------------------------------------
>98543_98543_8_VRK3-CBLC_VRK3_chr19_50504047_ENST00000377011_CBLC_chr19_45296731_ENST00000341505_length(transcript)=1011nt_BP=632nt
GGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCCAGAATCCCACCCCA
GTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATAAAGCATGATCTCCT
TCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGAGGAGCATGTAGGGT
CCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGA
AGAGCCCTCAGGTGACCAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCC
GAGTGACCACCTCACTTGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCA
GGGACAACCAGGGCATTCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAAC
TGCACTCGGACAGCCAGACCTGCCCCTTCTGCCGCTGCGAGATCAAGGGCTGGGAGGCCGTGAGTATCTACCAGTTCCACGGTCAGGCTA
CTGCTGAGGACTCAGGGAACAGCAGTGACCAGGAAGGCAGGGAGTTGGAGCTGGGGCAGGTGCCCCTTTCGGCTCCTCCATTGCCCCCAC
GGCCAGATCTGCCCCCCAGGAAGCCCAGAAATGCCCAGCCGAAAGTGAGACTCCTAAAGGGGAACTCCCCTCCAGCTGCGCTGGGACCCC
AGGACCCTGCCCCGGCCTGAAGGCCAGGGCACCCAGATGTGCTGCTCAAGGGAGCCCCAAGGGCTGGAAGGGGGTTGTGAAACCGAAATA

>98543_98543_8_VRK3-CBLC_VRK3_chr19_50504047_ENST00000377011_CBLC_chr19_45296731_ENST00000341505_length(amino acids)=249AA_BP=154
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTL
KRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLHSDSQTCPFCRCEIKGWEAVSIYQFH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for VRK3-CBLC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCBLCchr19:50504046chr19:45296730ENST00000341505510351_474333.0318.3333333333333RET
TgeneCBLCchr19:50504047chr19:45296731ENST00000341505510351_474333.0318.3333333333333RET


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCBLCchr19:50504046chr19:45296730ENST00000270279611351_474379.0364.3333333333333RET
TgeneCBLCchr19:50504047chr19:45296731ENST00000270279611351_474379.0364.3333333333333RET


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VRK3-CBLC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VRK3-CBLC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource