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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VRK3-PPP6R1 (FusionGDB2 ID:98547)

Fusion Gene Summary for VRK3-PPP6R1

check button Fusion gene summary
Fusion gene informationFusion gene name: VRK3-PPP6R1
Fusion gene ID: 98547
HgeneTgene
Gene symbol

VRK3

PPP6R1

Gene ID

51231

22870

Gene nameVRK serine/threonine kinase 3protein phosphatase 6 regulatory subunit 1
Synonyms-KIAA1115|PP6R1|SAP190|SAPS1
Cytomap

19q13.33

19q13.42

Type of geneprotein-codingprotein-coding
Descriptioninactive serine/threonine-protein kinase VRK3serine/threonine-protein kinase VRK3serine/threonine-protein pseudokinase VRK3vaccinia related kinase 3serine/threonine-protein phosphatase 6 regulatory subunit 1SAPS domain family, member 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000424804, ENST00000443401, 
ENST00000593919, ENST00000594092, 
ENST00000594948, ENST00000599538, 
ENST00000601341, ENST00000601912, 
ENST00000316763, ENST00000377011, 
ENST00000412770, ENST00000587283, 
Fusion gene scores* DoF score7 X 6 X 4=1687 X 6 X 4=168
# samples 98
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VRK3 [Title/Abstract] AND PPP6R1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVRK3(50504047)-PPP6R1(55753856), # samples:3
Anticipated loss of major functional domain due to fusion event.VRK3-PPP6R1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
VRK3-PPP6R1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
VRK3-PPP6R1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP6R1

GO:0043666

regulation of phosphoprotein phosphatase activity

16716191


check buttonFusion gene breakpoints across VRK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP6R1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-C5-A907-01AVRK3chr19

50504047

-PPP6R1chr19

55753856

-


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Fusion Gene ORF analysis for VRK3-PPP6R1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000424804ENST00000412770VRK3chr19

50504047

-PPP6R1chr19

55753856

-
5UTR-3CDSENST00000424804ENST00000587283VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000443401ENST00000412770VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000443401ENST00000587283VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000593919ENST00000412770VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000593919ENST00000587283VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000594092ENST00000412770VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000594092ENST00000587283VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000594948ENST00000412770VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000594948ENST00000587283VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000599538ENST00000412770VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000599538ENST00000587283VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000601341ENST00000412770VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000601341ENST00000587283VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000601912ENST00000412770VRK3chr19

50504047

-PPP6R1chr19

55753856

-
Frame-shiftENST00000601912ENST00000587283VRK3chr19

50504047

-PPP6R1chr19

55753856

-
In-frameENST00000316763ENST00000412770VRK3chr19

50504047

-PPP6R1chr19

55753856

-
In-frameENST00000316763ENST00000587283VRK3chr19

50504047

-PPP6R1chr19

55753856

-
In-frameENST00000377011ENST00000412770VRK3chr19

50504047

-PPP6R1chr19

55753856

-
In-frameENST00000377011ENST00000587283VRK3chr19

50504047

-PPP6R1chr19

55753856

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000316763VRK3chr1950504047-ENST00000412770PPP6R1chr1955753856-35727961842823879
ENST00000316763VRK3chr1950504047-ENST00000587283PPP6R1chr1955753856-28627961842823879
ENST00000377011VRK3chr1950504047-ENST00000412770PPP6R1chr1955753856-34086321702659829
ENST00000377011VRK3chr1950504047-ENST00000587283PPP6R1chr1955753856-26986321702659829

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000316763ENST00000412770VRK3chr1950504047-PPP6R1chr1955753856-0.0066864380.9933136
ENST00000316763ENST00000587283VRK3chr1950504047-PPP6R1chr1955753856-0.0145985810.98540145
ENST00000377011ENST00000412770VRK3chr1950504047-PPP6R1chr1955753856-0.0092070830.99079293
ENST00000377011ENST00000587283VRK3chr1950504047-PPP6R1chr1955753856-0.0213938410.97860616

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Fusion Genomic Features for VRK3-PPP6R1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VRK3-PPP6R1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:50504047/chr19:55753856)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVRK3chr19:50504047chr19:55753856ENST00000316763-61549_64204573.3333333333334MotifNuclear localization signal
HgeneVRK3chr19:50504047chr19:55753856ENST00000377011-51449_64154519.6666666666666MotifNuclear localization signal
HgeneVRK3chr19:50504047chr19:55753856ENST00000594092-61349_64204413.0MotifNuclear localization signal
HgeneVRK3chr19:50504047chr19:55753856ENST00000594948-61449_64204475.0MotifNuclear localization signal
HgeneVRK3chr19:50504047chr19:55753856ENST00000599538-61549_64204315.3333333333333MotifNuclear localization signal
HgeneVRK3chr19:50504047chr19:55753856ENST00000601341-51349_64154425.0MotifNuclear localization signal
TgenePPP6R1chr19:50504047chr19:55753856ENST00000412770424624_631206882.0Compositional biasNote=Poly-Glu
TgenePPP6R1chr19:50504047chr19:55753856ENST00000412770424624_685206882.0Compositional biasNote=Glu-rich
TgenePPP6R1chr19:50504047chr19:55753856ENST00000412770424671_685206882.0Compositional biasNote=Poly-Glu
TgenePPP6R1chr19:50504047chr19:55753856ENST00000412770424697_878206882.0Compositional biasNote=Pro-rich
TgenePPP6R1chr19:50504047chr19:55753856ENST00000587283323624_631206882.0Compositional biasNote=Poly-Glu
TgenePPP6R1chr19:50504047chr19:55753856ENST00000587283323624_685206882.0Compositional biasNote=Glu-rich
TgenePPP6R1chr19:50504047chr19:55753856ENST00000587283323671_685206882.0Compositional biasNote=Poly-Glu
TgenePPP6R1chr19:50504047chr19:55753856ENST00000587283323697_878206882.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVRK3chr19:50504047chr19:55753856ENST00000316763-615166_457204573.3333333333334DomainProtein kinase
HgeneVRK3chr19:50504047chr19:55753856ENST00000377011-514166_457154519.6666666666666DomainProtein kinase
HgeneVRK3chr19:50504047chr19:55753856ENST00000594092-613166_457204413.0DomainProtein kinase
HgeneVRK3chr19:50504047chr19:55753856ENST00000594948-614166_457204475.0DomainProtein kinase
HgeneVRK3chr19:50504047chr19:55753856ENST00000599538-615166_457204315.3333333333333DomainProtein kinase
HgeneVRK3chr19:50504047chr19:55753856ENST00000601341-513166_457154425.0DomainProtein kinase


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Fusion Gene Sequence for VRK3-PPP6R1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98547_98547_1_VRK3-PPP6R1_VRK3_chr19_50504047_ENST00000316763_PPP6R1_chr19_55753856_ENST00000412770_length(transcript)=3572nt_BP=796nt
GCTCTCCGCCCAGCGGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCC
AGAATCCCACCCCAGTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATA
AAGCATGATCTCCTTCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGA
GGAGCATGTAGGGTCCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCAAAGAGAGGGCTGAACTCCAGTTTTGAAACCTC
TCCTAAGAAAGTGAAATGGTCCAGCACCGTCACCTCTCCCCGATTATCCCTCTTCTCAGATGGTGACAGTTCTGAGTCTGAAGATACTCT
GAGTTCCTCTGAGAGATCCAAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGAAGAGCCCTCAGGTGAC
CAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCCGAGTGACCACCTCACT
TGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCAGGGACAACCAGGGCAT
TCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAACTGCAACATTCCAACGC
ATCCCAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGACAGCCCAGAGCCTGACCAACTGCTGGCCAC
CCTGGAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGCCAGTCTGTCATCGTCAGTGGGATCCAGGT
GCTGCTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTCTTCAGCAGTGTGGATGGGCAGCTGGAGCT
CCTGGCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGCCCGCGGCTCAGCTGCTTCCACCAGCTCCT
GCTGGAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTGGGCAACACGCGGCTGCACGTGGTCAAGCT
CCTGGCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGACGTGCCCAACACCATGCTGGACCTCTTCTT
CCATTATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTGAGCTTGGGGCCACCTCCTGACAGCAGCCC
TGAGACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAGCGGATCCTGACGTCCTGGGAGGAGAACGA
CCGTGTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCCGGTGCCCTGGTGCAGAACACGGAGAAGGG
GCCCAATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAGTGGGAAGCCTTCGTATCGGGGCCCCTGGC
GGAGACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGTGACGATGAGGACGACCGGCTCAAGGAGTT
CAACTTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATGACCTCTGCCTTCATTGACCACTTCGGCTT
CAATGATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAACGCACCTTTTGACAAGACAGCCAACATCACCTTCTCCCTCAATGCTGACGA
TGAGAACCCCAACGCCAACCTACTTGAGATATGCTACAAGGACCGCATCCAGCAGTTTGATGATGATGAGGAAGAGGAGGACGAGGAAGA
GGCCCAGGGCTCAGGGGAGTCTGATGGAGAAGATGGCGCCTGGCAGGGCAGCCAGCTGGCCAGGGGGGCCCGTCTGGGCCAGCCACCTGG
TGTCCGGAGTGGAGGCAGCACAGACAGTGAGGACGAAGAAGAGGAGGACGAGGAGGAGGAGGAAGACGAGGAGGGCATTGGCTGTGCAGC
CCGTGGAGGGGCCACCCCTCTGTCCTACCCCAGCCCTGGCCCTCAGCCTCCAGGCCCCAGCTGGACAGCCACCTTTGACCCAGTGCCTAC
AGATGCCCCGACCAGCCCCCGAGTCTCCGGGGAGGAAGAGCTGCACACTGGGCCTCCAGCCCCACAGGGGCCCCTCAGTGTGCCCCAGGG
CCTCCCCACTCAGAGCCTGGCCAGCCCTCCTGCCCGTGACGCCCTGCAGCTCAGGTCTCAGGACCCCACACCCCCCTCAGCACCTCAGGA
AGCCACAGAAGGCAGCAAAGTCACGGAGCCCTCAGCCCCTTGCCAGGCCTTGGTTAGCATCGGGGACCTTCAGGCCACCTTCCACGGGAT
CCGTTCTGCCCCCAGCTCCTCGGACAGTGCAACCAGAGACCCCTCTACCTCTGTCCCAGCCTCCGGGGCCCACCAGCCCCCCCAGACCAC
AGAAGGGGAGAAGAGCCCAGAGCCCTTGGGGCTTCCCCAAAGCCAGAGTGCCCAGGCCCTCACGCCTCCTCCGATACCCAATGGCTCTGC
CCCGGAAGGGCCTGCATCCCCAGGCTCCCAATAGCTGCCTGGTGCGGCAGCGGCGGCCAAATCTTCCGTCCTCCCGTGGATCTCCCGGGG
TGGGGGCAGGGCGGGTCCCACGATGGCCCCCATTGCCCTCATCACCCTGACACCCCCACATTCTCTCCTCTGGACCCCCAGGAGGCTGGT
GCCAGGGAGACAGGCCCAACCCACCCCCATTTGCACTGAGAAGAGAAGTTTTGGAGCGTTGCCTCCTAGAATAAAGATACAGAGAGTCAA
ATAGAGAGAATGGAGAGAGAGAAACATATATTATATATTATATAGAGAGAGGGAGGAGAGCGAGAGAGAGTGAGGACACCGAACTGGGCT
GGCGGCTCCAAAGCACAGCCTTCCCTGTTCCGTCCCAGCGGGAGCTGGTGTTAGGGGTCCCAAGGTTGCCACCCACGTGCCCAGCTGTCC
CACGCTGCAGCGCAGACGGCCACGCCCACACCCGGCCTTTTAGCTCAGGTCCACCATGGGGGACGGCCCAGCGTGGGTGGGGGTGCCAGA
GGGTCCCGAGTGGGGGCCGTGCCTTTGCCCAGACCCTGCACTTTCAACCAGGCCAGTCCGGCTCTGGGGAGCAGGGGCCTCCCCGGCAAC
AGCCCCAGGGGCCTTGAGGGTCTGAGGTCCCAGCCCTGTTGCCAAGTGACCTTGTCCCCAGCTCCCTCCTCCCAGGCTGGTGTGAGTGTG

>98547_98547_1_VRK3-PPP6R1_VRK3_chr19_50504047_ENST00000316763_PPP6R1_chr19_55753856_ENST00000412770_length(amino acids)=879AA_BP=204
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLS
SSERSKGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL
YEAAPTSTLTCDSGPQKQKFSLKLQHSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVL
LTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLL
ASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSLGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDR
VQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQWEAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFN
FPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEA
QGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTD
APTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIR

--------------------------------------------------------------
>98547_98547_2_VRK3-PPP6R1_VRK3_chr19_50504047_ENST00000316763_PPP6R1_chr19_55753856_ENST00000587283_length(transcript)=2862nt_BP=796nt
GCTCTCCGCCCAGCGGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCC
AGAATCCCACCCCAGTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATA
AAGCATGATCTCCTTCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGA
GGAGCATGTAGGGTCCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCAAAGAGAGGGCTGAACTCCAGTTTTGAAACCTC
TCCTAAGAAAGTGAAATGGTCCAGCACCGTCACCTCTCCCCGATTATCCCTCTTCTCAGATGGTGACAGTTCTGAGTCTGAAGATACTCT
GAGTTCCTCTGAGAGATCCAAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGAAGAGCCCTCAGGTGAC
CAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCCGAGTGACCACCTCACT
TGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCAGGGACAACCAGGGCAT
TCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAACTGCAACATTCCAACGC
ATCCCAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGACAGCCCAGAGCCTGACCAACTGCTGGCCAC
CCTGGAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGCCAGTCTGTCATCGTCAGTGGGATCCAGGT
GCTGCTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTCTTCAGCAGTGTGGATGGGCAGCTGGAGCT
CCTGGCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGCCCGCGGCTCAGCTGCTTCCACCAGCTCCT
GCTGGAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTGGGCAACACGCGGCTGCACGTGGTCAAGCT
CCTGGCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGACGTGCCCAACACCATGCTGGACCTCTTCTT
CCATTATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTGAGCTTGGGGCCACCTCCTGACAGCAGCCC
TGAGACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAGCGGATCCTGACGTCCTGGGAGGAGAACGA
CCGTGTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCCGGTGCCCTGGTGCAGAACACGGAGAAGGG
GCCCAATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAGTGGGAAGCCTTCGTATCGGGGCCCCTGGC
GGAGACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGTGACGATGAGGACGACCGGCTCAAGGAGTT
CAACTTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATGACCTCTGCCTTCATTGACCACTTCGGCTT
CAATGATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAACGCACCTTTTGACAAGACAGCCAACATCACCTTCTCCCTCAATGCTGACGA
TGAGAACCCCAACGCCAACCTACTTGAGATATGCTACAAGGACCGCATCCAGCAGTTTGATGATGATGAGGAAGAGGAGGACGAGGAAGA
GGCCCAGGGCTCAGGGGAGTCTGATGGAGAAGATGGCGCCTGGCAGGGCAGCCAGCTGGCCAGGGGGGCCCGTCTGGGCCAGCCACCTGG
TGTCCGGAGTGGAGGCAGCACAGACAGTGAGGACGAAGAAGAGGAGGACGAGGAGGAGGAGGAAGACGAGGAGGGCATTGGCTGTGCAGC
CCGTGGAGGGGCCACCCCTCTGTCCTACCCCAGCCCTGGCCCTCAGCCTCCAGGCCCCAGCTGGACAGCCACCTTTGACCCAGTGCCTAC
AGATGCCCCGACCAGCCCCCGAGTCTCCGGGGAGGAAGAGCTGCACACTGGGCCTCCAGCCCCACAGGGGCCCCTCAGTGTGCCCCAGGG
CCTCCCCACTCAGAGCCTGGCCAGCCCTCCTGCCCGTGACGCCCTGCAGCTCAGGTCTCAGGACCCCACACCCCCCTCAGCACCTCAGGA
AGCCACAGAAGGCAGCAAAGTCACGGAGCCCTCAGCCCCTTGCCAGGCCTTGGTTAGCATCGGGGACCTTCAGGCCACCTTCCACGGGAT
CCGTTCTGCCCCCAGCTCCTCGGACAGTGCAACCAGAGACCCCTCTACCTCTGTCCCAGCCTCCGGGGCCCACCAGCCCCCCCAGACCAC
AGAAGGGGAGAAGAGCCCAGAGCCCTTGGGGCTTCCCCAAAGCCAGAGTGCCCAGGCCCTCACGCCTCCTCCGATACCCAATGGCTCTGC

>98547_98547_2_VRK3-PPP6R1_VRK3_chr19_50504047_ENST00000316763_PPP6R1_chr19_55753856_ENST00000587283_length(amino acids)=879AA_BP=204
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLS
SSERSKGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL
YEAAPTSTLTCDSGPQKQKFSLKLQHSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVL
LTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLL
ASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSLGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDR
VQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQWEAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFN
FPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEA
QGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTD
APTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIR

--------------------------------------------------------------
>98547_98547_3_VRK3-PPP6R1_VRK3_chr19_50504047_ENST00000377011_PPP6R1_chr19_55753856_ENST00000412770_length(transcript)=3408nt_BP=632nt
GGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCCAGAATCCCACCCCA
GTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATAAAGCATGATCTCCT
TCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGAGGAGCATGTAGGGT
CCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGA
AGAGCCCTCAGGTGACCAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCC
GAGTGACCACCTCACTTGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCA
GGGACAACCAGGGCATTCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAAC
TGCAACATTCCAACGCATCCCAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGACAGCCCAGAGCCTG
ACCAACTGCTGGCCACCCTGGAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGCCAGTCTGTCATCG
TCAGTGGGATCCAGGTGCTGCTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTCTTCAGCAGTGTGG
ATGGGCAGCTGGAGCTCCTGGCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGCCCGCGGCTCAGCT
GCTTCCACCAGCTCCTGCTGGAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTGGGCAACACGCGGC
TGCACGTGGTCAAGCTCCTGGCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGACGTGCCCAACACCA
TGCTGGACCTCTTCTTCCATTATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTGAGCTTGGGGCCAC
CTCCTGACAGCAGCCCTGAGACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAGCGGATCCTGACGT
CCTGGGAGGAGAACGACCGTGTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCCGGTGCCCTGGTGC
AGAACACGGAGAAGGGGCCCAATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAGTGGGAAGCCTTCG
TATCGGGGCCCCTGGCGGAGACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGTGACGATGAGGACG
ACCGGCTCAAGGAGTTCAACTTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATGACCTCTGCCTTCA
TTGACCACTTCGGCTTCAATGATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAACGCACCTTTTGACAAGACAGCCAACATCACCTTCT
CCCTCAATGCTGACGATGAGAACCCCAACGCCAACCTACTTGAGATATGCTACAAGGACCGCATCCAGCAGTTTGATGATGATGAGGAAG
AGGAGGACGAGGAAGAGGCCCAGGGCTCAGGGGAGTCTGATGGAGAAGATGGCGCCTGGCAGGGCAGCCAGCTGGCCAGGGGGGCCCGTC
TGGGCCAGCCACCTGGTGTCCGGAGTGGAGGCAGCACAGACAGTGAGGACGAAGAAGAGGAGGACGAGGAGGAGGAGGAAGACGAGGAGG
GCATTGGCTGTGCAGCCCGTGGAGGGGCCACCCCTCTGTCCTACCCCAGCCCTGGCCCTCAGCCTCCAGGCCCCAGCTGGACAGCCACCT
TTGACCCAGTGCCTACAGATGCCCCGACCAGCCCCCGAGTCTCCGGGGAGGAAGAGCTGCACACTGGGCCTCCAGCCCCACAGGGGCCCC
TCAGTGTGCCCCAGGGCCTCCCCACTCAGAGCCTGGCCAGCCCTCCTGCCCGTGACGCCCTGCAGCTCAGGTCTCAGGACCCCACACCCC
CCTCAGCACCTCAGGAAGCCACAGAAGGCAGCAAAGTCACGGAGCCCTCAGCCCCTTGCCAGGCCTTGGTTAGCATCGGGGACCTTCAGG
CCACCTTCCACGGGATCCGTTCTGCCCCCAGCTCCTCGGACAGTGCAACCAGAGACCCCTCTACCTCTGTCCCAGCCTCCGGGGCCCACC
AGCCCCCCCAGACCACAGAAGGGGAGAAGAGCCCAGAGCCCTTGGGGCTTCCCCAAAGCCAGAGTGCCCAGGCCCTCACGCCTCCTCCGA
TACCCAATGGCTCTGCCCCGGAAGGGCCTGCATCCCCAGGCTCCCAATAGCTGCCTGGTGCGGCAGCGGCGGCCAAATCTTCCGTCCTCC
CGTGGATCTCCCGGGGTGGGGGCAGGGCGGGTCCCACGATGGCCCCCATTGCCCTCATCACCCTGACACCCCCACATTCTCTCCTCTGGA
CCCCCAGGAGGCTGGTGCCAGGGAGACAGGCCCAACCCACCCCCATTTGCACTGAGAAGAGAAGTTTTGGAGCGTTGCCTCCTAGAATAA
AGATACAGAGAGTCAAATAGAGAGAATGGAGAGAGAGAAACATATATTATATATTATATAGAGAGAGGGAGGAGAGCGAGAGAGAGTGAG
GACACCGAACTGGGCTGGCGGCTCCAAAGCACAGCCTTCCCTGTTCCGTCCCAGCGGGAGCTGGTGTTAGGGGTCCCAAGGTTGCCACCC
ACGTGCCCAGCTGTCCCACGCTGCAGCGCAGACGGCCACGCCCACACCCGGCCTTTTAGCTCAGGTCCACCATGGGGGACGGCCCAGCGT
GGGTGGGGGTGCCAGAGGGTCCCGAGTGGGGGCCGTGCCTTTGCCCAGACCCTGCACTTTCAACCAGGCCAGTCCGGCTCTGGGGAGCAG
GGGCCTCCCCGGCAACAGCCCCAGGGGCCTTGAGGGTCTGAGGTCCCAGCCCTGTTGCCAAGTGACCTTGTCCCCAGCTCCCTCCTCCCA

>98547_98547_3_VRK3-PPP6R1_VRK3_chr19_50504047_ENST00000377011_PPP6R1_chr19_55753856_ENST00000412770_length(amino acids)=829AA_BP=154
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTL
KRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLQHSNASQSLCDIIRLSREQMIQVQDS
PEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRP
RLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLS
LGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQW
EAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTAN
ITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEAQGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEE
DEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQD
PTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALT

--------------------------------------------------------------
>98547_98547_4_VRK3-PPP6R1_VRK3_chr19_50504047_ENST00000377011_PPP6R1_chr19_55753856_ENST00000587283_length(transcript)=2698nt_BP=632nt
GGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCCAGAATCCCACCCCA
GTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATAAAGCATGATCTCCT
TCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGAGGAGCATGTAGGGT
CCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGA
AGAGCCCTCAGGTGACCAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCC
GAGTGACCACCTCACTTGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCA
GGGACAACCAGGGCATTCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAAC
TGCAACATTCCAACGCATCCCAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGACAGCCCAGAGCCTG
ACCAACTGCTGGCCACCCTGGAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGCCAGTCTGTCATCG
TCAGTGGGATCCAGGTGCTGCTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTCTTCAGCAGTGTGG
ATGGGCAGCTGGAGCTCCTGGCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGCCCGCGGCTCAGCT
GCTTCCACCAGCTCCTGCTGGAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTGGGCAACACGCGGC
TGCACGTGGTCAAGCTCCTGGCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGACGTGCCCAACACCA
TGCTGGACCTCTTCTTCCATTATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTGAGCTTGGGGCCAC
CTCCTGACAGCAGCCCTGAGACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAGCGGATCCTGACGT
CCTGGGAGGAGAACGACCGTGTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCCGGTGCCCTGGTGC
AGAACACGGAGAAGGGGCCCAATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAGTGGGAAGCCTTCG
TATCGGGGCCCCTGGCGGAGACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGTGACGATGAGGACG
ACCGGCTCAAGGAGTTCAACTTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATGACCTCTGCCTTCA
TTGACCACTTCGGCTTCAATGATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAACGCACCTTTTGACAAGACAGCCAACATCACCTTCT
CCCTCAATGCTGACGATGAGAACCCCAACGCCAACCTACTTGAGATATGCTACAAGGACCGCATCCAGCAGTTTGATGATGATGAGGAAG
AGGAGGACGAGGAAGAGGCCCAGGGCTCAGGGGAGTCTGATGGAGAAGATGGCGCCTGGCAGGGCAGCCAGCTGGCCAGGGGGGCCCGTC
TGGGCCAGCCACCTGGTGTCCGGAGTGGAGGCAGCACAGACAGTGAGGACGAAGAAGAGGAGGACGAGGAGGAGGAGGAAGACGAGGAGG
GCATTGGCTGTGCAGCCCGTGGAGGGGCCACCCCTCTGTCCTACCCCAGCCCTGGCCCTCAGCCTCCAGGCCCCAGCTGGACAGCCACCT
TTGACCCAGTGCCTACAGATGCCCCGACCAGCCCCCGAGTCTCCGGGGAGGAAGAGCTGCACACTGGGCCTCCAGCCCCACAGGGGCCCC
TCAGTGTGCCCCAGGGCCTCCCCACTCAGAGCCTGGCCAGCCCTCCTGCCCGTGACGCCCTGCAGCTCAGGTCTCAGGACCCCACACCCC
CCTCAGCACCTCAGGAAGCCACAGAAGGCAGCAAAGTCACGGAGCCCTCAGCCCCTTGCCAGGCCTTGGTTAGCATCGGGGACCTTCAGG
CCACCTTCCACGGGATCCGTTCTGCCCCCAGCTCCTCGGACAGTGCAACCAGAGACCCCTCTACCTCTGTCCCAGCCTCCGGGGCCCACC
AGCCCCCCCAGACCACAGAAGGGGAGAAGAGCCCAGAGCCCTTGGGGCTTCCCCAAAGCCAGAGTGCCCAGGCCCTCACGCCTCCTCCGA

>98547_98547_4_VRK3-PPP6R1_VRK3_chr19_50504047_ENST00000377011_PPP6R1_chr19_55753856_ENST00000587283_length(amino acids)=829AA_BP=154
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTL
KRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLQHSNASQSLCDIIRLSREQMIQVQDS
PEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRP
RLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLS
LGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQW
EAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTAN
ITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEAQGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEE
DEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQD
PTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for VRK3-PPP6R1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePPP6R1chr19:50504047chr19:55753856ENST0000041277042410_403206.0882.0PPP6C
TgenePPP6R1chr19:50504047chr19:55753856ENST0000058728332310_403206.0882.0PPP6C


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VRK3-PPP6R1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VRK3-PPP6R1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource