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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VTI1A-GLS (FusionGDB2 ID:98587)

Fusion Gene Summary for VTI1A-GLS

check button Fusion gene summary
Fusion gene informationFusion gene name: VTI1A-GLS
Fusion gene ID: 98587
HgeneTgene
Gene symbol

VTI1A

GLS

Gene ID

143187

27165

Gene namevesicle transport through interaction with t-SNAREs 1Aglutaminase 2
SynonymsMMDS3|MVti1|VTI1RP2|Vti1-rp2GA|GLS|LGA|hLGA
Cytomap

10q25.2

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionvesicle transport through interaction with t-SNAREs homolog 1ASNARE Vti1a-beta proteinvesicle transport v-SNARE protein Vti1-like 2glutaminase liver isoform, mitochondrialL-glutamine amidohydrolasebreast cell glutaminaseglutaminase 2 (liver, mitochondrial)glutaminase Iphosphate-activated glutaminasephosphate-dependent glutaminase
Modification date2020031320200313
UniProtAcc.

Q9UI32

Ensembl transtripts involved in fusion geneENST00000393077, ENST00000432306, 
ENST00000483122, 		ENST00000409626, 
ENST00000409215, ENST00000409428, 
ENST00000471443, ENST00000320717, 
ENST00000338435, 
Fusion gene scores* DoF score15 X 12 X 12=216012 X 9 X 5=540
# samples 2412
** MAII scorelog2(24/2160*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VTI1A [Title/Abstract] AND GLS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVTI1A(114224416)-GLS(191792032), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneVTI1A

GO:0042147

retrograde transport, endosome to Golgi

15215310|18195106


check buttonFusion gene breakpoints across VTI1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GLS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-8574-01AVTI1Achr10

114224416

+GLSchr2

191792032

+


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Fusion Gene ORF analysis for VTI1A-GLS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000393077ENST00000409626VTI1Achr10

114224416

+GLSchr2

191792032

+
5CDS-5UTRENST00000432306ENST00000409626VTI1Achr10

114224416

+GLSchr2

191792032

+
5CDS-intronENST00000393077ENST00000409215VTI1Achr10

114224416

+GLSchr2

191792032

+
5CDS-intronENST00000393077ENST00000409428VTI1Achr10

114224416

+GLSchr2

191792032

+
5CDS-intronENST00000393077ENST00000471443VTI1Achr10

114224416

+GLSchr2

191792032

+
5CDS-intronENST00000432306ENST00000409215VTI1Achr10

114224416

+GLSchr2

191792032

+
5CDS-intronENST00000432306ENST00000409428VTI1Achr10

114224416

+GLSchr2

191792032

+
5CDS-intronENST00000432306ENST00000471443VTI1Achr10

114224416

+GLSchr2

191792032

+
In-frameENST00000393077ENST00000320717VTI1Achr10

114224416

+GLSchr2

191792032

+
In-frameENST00000393077ENST00000338435VTI1Achr10

114224416

+GLSchr2

191792032

+
In-frameENST00000432306ENST00000320717VTI1Achr10

114224416

+GLSchr2

191792032

+
In-frameENST00000432306ENST00000338435VTI1Achr10

114224416

+GLSchr2

191792032

+
intron-3CDSENST00000483122ENST00000320717VTI1Achr10

114224416

+GLSchr2

191792032

+
intron-3CDSENST00000483122ENST00000338435VTI1Achr10

114224416

+GLSchr2

191792032

+
intron-5UTRENST00000483122ENST00000409626VTI1Achr10

114224416

+GLSchr2

191792032

+
intron-intronENST00000483122ENST00000409215VTI1Achr10

114224416

+GLSchr2

191792032

+
intron-intronENST00000483122ENST00000409428VTI1Achr10

114224416

+GLSchr2

191792032

+
intron-intronENST00000483122ENST00000471443VTI1Achr10

114224416

+GLSchr2

191792032

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000432306VTI1Achr10114224416+ENST00000320717GLSchr2191792032+3708380861141351
ENST00000432306VTI1Achr10114224416+ENST00000338435GLSchr2191792032+335638086928280
ENST00000393077VTI1Achr10114224416+ENST00000320717GLSchr2191792032+3708380861141351
ENST00000393077VTI1Achr10114224416+ENST00000338435GLSchr2191792032+335638086928280

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000432306ENST00000320717VTI1Achr10114224416+GLSchr2191792032+0.0002019350.9997981
ENST00000432306ENST00000338435VTI1Achr10114224416+GLSchr2191792032+0.0002050370.999795
ENST00000393077ENST00000320717VTI1Achr10114224416+GLSchr2191792032+0.0002019350.9997981
ENST00000393077ENST00000338435VTI1Achr10114224416+GLSchr2191792032+0.0002050370.999795

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Fusion Genomic Features for VTI1A-GLS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
VTI1Achr10114224416+GLSchr2191792031+1.21E-081
VTI1Achr10114224416+GLSchr2191792031+1.21E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for VTI1A-GLS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:114224416/chr2:191792032)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GLS

Q9UI32

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. {ECO:0000269|PubMed:20378837}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGLSchr10:114224416chr2:191792032ENST000003207171018585_614416670.0RepeatNote=ANK 1
TgeneGLSchr10:114224416chr2:191792032ENST000003207171018619_648416670.0RepeatNote=ANK 2
TgeneGLSchr10:114224416chr2:191792032ENST000003384351015585_614416599.0RepeatNote=ANK 1
TgeneGLSchr10:114224416chr2:191792032ENST000003384351015619_648416599.0RepeatNote=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVTI1Achr10:114224416chr2:191792032ENST00000393077+38112_17888218.0Coiled coilOntology_term=ECO:0000255
HgeneVTI1Achr10:114224416chr2:191792032ENST00000393077+3831_9288218.0Coiled coilOntology_term=ECO:0000255
HgeneVTI1Achr10:114224416chr2:191792032ENST00000432306+38112_17888204.0Coiled coilOntology_term=ECO:0000255
HgeneVTI1Achr10:114224416chr2:191792032ENST00000432306+3831_9288204.0Coiled coilOntology_term=ECO:0000255
HgeneVTI1Achr10:114224416chr2:191792032ENST00000393077+381_19288218.0Topological domainCytoplasmic
HgeneVTI1Achr10:114224416chr2:191792032ENST00000393077+38214_21788218.0Topological domainExtracellular
HgeneVTI1Achr10:114224416chr2:191792032ENST00000432306+381_19288204.0Topological domainCytoplasmic
HgeneVTI1Achr10:114224416chr2:191792032ENST00000432306+38214_21788204.0Topological domainExtracellular
HgeneVTI1Achr10:114224416chr2:191792032ENST00000393077+38193_21388218.0TransmembraneHelical
HgeneVTI1Achr10:114224416chr2:191792032ENST00000432306+38193_21388204.0TransmembraneHelical
TgeneGLSchr10:114224416chr2:191792032ENST000003207171018315_322416670.0RegionHighly mobile activation loop
TgeneGLSchr10:114224416chr2:191792032ENST000003384351015315_322416599.0RegionHighly mobile activation loop


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Fusion Gene Sequence for VTI1A-GLS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98587_98587_1_VTI1A-GLS_VTI1A_chr10_114224416_ENST00000393077_GLS_chr2_191792032_ENST00000320717_length(transcript)=3708nt_BP=380nt
CCGTTCTGCTCTCGGGGGCACCTTCCGGGGTTCCTAAGCCGCGGGGCCCCTCGCTGCCCCTCGAGGCCCTTTCCCTGACCTAGGCTTTGG
CCTGGGCTACTCGTTCCGGAGCCGCCATGTCGTCCGACTTCGAAGGTTACGAGCAGGACTTCGCGGTGCTCACTGCAGAGATCACCAGCA
AGATTGCGAGGGTCCCACGACTCCCGCCTGATGAAAAGAAACAGATGGTTGCAAATGTGGAGAAACAGCTTGAAGAAGCGAAAGAACTGC
TTGAACAGATGGATTTGGAAGTCCGAGAGATACCACCCCAAAGTCGAGGGATGTACAGCAACAGAATGAGAAGCTACAAACAAGAAATGG
GAAAACTCGAAACAGATTTTCTGTGCTCCATTGAAGTGACTTGTGAATCAGCCAGTGTGATGGCTGCGACACTGGCTAATGGTGGTTTCT
GCCCAATTACTGGTGAAAGAGTACTGAGCCCTGAAGCAGTTCGAAATACATTGAGTTTGATGCATTCCTGTGGCATGTATGACTTCTCAG
GGCAGTTTGCTTTCCATGTTGGTCTTCCTGCAAAATCTGGAGTTGCTGGGGGCATTCTTTTAGTTGTCCCCAATGTTATGGGTATGATGT
GCTGGTCTCCTCCTCTGGATAAGATGGGCAACAGTGTTAAGGGAATTCACTTTTGTCACGATCTTGTTTCTCTGTGTAATTTCCATAACT
ATGATAATTTGAGACACTTTGCAAAAAAACTTGATCCTCGAAGAGAAGGTGGTGATCAAAGGGTAAAGTCAGTGATAAATCTTTTGTTTG
CTGCATATACTGGAGATGTGTCTGCACTTCGAAGATTTGCTTTGTCAGCTATGGACATGGAACAGCGGGACTATGATTCTAGAACAGCAC
TCCATGTAGCTGCTGCAGAGGGTCATGTTGAAGTTGTTAAATTTTTGCTGGAAGCCTGCAAAGTAAACCCTTTCCCCAAGGACAGGTGGA
ATAACACTCCCATGGATGAAGCACTGCACTTTGGACACCATGATGTATTTAAAATTCTCCAAGAATACCAAGTCCAGTACACACCTCAAG
GAGATTCTGACAACGGGAAGGAAAATCAAACCGTCCATAAGAATCTTGATGGATTGTTGTAATGGTCTCAAATCCCAAGATTTAAATCAC
TTACCTATTTAATTGTGGAAAATGATTATGAAGAACATGTGTATTTCTATCTGGTAGTGATGTATATTTTACATTTGTCATTTCAGTGTT
ACTGGAGTTTTCTTCATTGTGCACACAGGACAAATCTGATCTCTTTGGGAAAAAATAGAAATAAAACAATCTCCCTCCATAATGTGAGCA
ATATTACCTCGTGCATTGTATAATTTGATGTAAAAGAAATAGTTACCAATGCTAGCTTGTGTGGTCTTCCATGATTTATTTGTGTTTTGT
GAATTTTCAATTTATGGTGATGATCTGCTGATATGCATTTATAAAGTAAGCTCTGTTGTACAGTCTGTCCAAATGGGTCAAGGTTGCCTT
TAGAAGCAAATAGTGTGATTTTCAAGACTTCAAATACAAATTTAGTTTAAGTGTTTGAACAACTATATGCACTTACGGTTGTGTGTTTAA
AATGTCTCTCTCACCCCCTAGCTTCATGATGTGACTCTTAAAAAACTATAATAGTTAACAACTGTTAGTAAGATAGACCAATTCTGATTA
GACTTTATCAGGGAATCTGTTTAAGATATGTTTGGTGACCAAAACGTATGTGTGAATGTAGTTATAATGCTTTTGAAAAATTTTCCTTTT
TCTATATCCCCTTAGTCCAGCCTCTCTTCTCAGACATTTAGCTATCTGCCTCTTTCCTTTAGCTGGGAAAGTGAGAGCTGGCATACTATG
CAGTTTTTATGTTTTCCATAGTAAGTCAGAAAATGCCTCCTATTTCTGGCATCAGAACTTTGCCATTTGTCTACAGAAGACGAACCAGAG
ACAAAATTACTAAGTATAAATTAGTCAAGTTTATCAGTCTAAAAAACGAAGGGATGTGCAACTGCAGCTCTTTAAGAAGTTTTTTTTTTT
TAGCTTCTAGGGTAAAGATAAATTCAGAAATGCTCTAAGCTACCAAAGTTATTCTGAAAGTATGGGAACTGCTACAACTAACAAACATTT
GTTTCCAAGCCTGTCATTAAGAGTCTGCATCAAGAGATTTGTCCTCCTTGGGGGACCACTGGATCATTCCAGATTTCTTGTGATTTTTCT
ATTGTGTAATTCTTGGTGGGCTCTGTAGTTTAATAATAAGAAAAAGGCCATTTCATTTTAAATTGTGACCTATAATTCTTTGTCTTGGGT
TGGTAATTCAGGATTCATTTGGAAAGTGGGTAAAAGGGGCTTCAAAAAACGGATAGAACAGGATTTTCTAGGAGTTACACATACATTTTA
TCCTGTCATACCTCGAGATAAAGTGGCATGTTAGTGAGGAGTTCTGATATTAAGCACACACACACATGCACACAAATGGACTTCTCTGAA
GCTGTGTTTAGTGAAATGAGCTCAAGTACATGAATGTTAGTTGTTATCACATACAGCAAATTCCTTTTTTTTTCTTTTTCTATGAGCACA
CTCTGCTGCTTCTAAACTTTACATGCCTGATGGCACCTTACTCCAGCAGCCTCCAGGTGCTTTCATTTTCACTTCCAGTCTAAGCCAGTG
GCTCCTGCCACTGCCCTCCCATTACCTAGATGGCACCTCCTTTGGTGAAACCACGGCCAATGTTCCTTAGCTGCACCAGGCCCGAAGCTG
TTCCCATGCTTGAGCTTCCATGGGGAGGATGCTGAGTGAGCAGTTTCCTACCCCGTGGATCTAGCAAGCCATGGAGACAGGTAGCATTTG
TAAGATGCTGCACAGGAGCAGCATTATCCCCAAAGATATTACAGGGTAGACACGTTTTAACTGAAATCAATCAAGATAACTTTATTCAAA
GAGCAGCCCGCTTTGTGTGACTAAAATGAAACAAGACAGTTGAATTGTGTGACTTGAAGATTACCAATGATTTTGAGGCTTTTCTATAAT
AAAAAGAGGTTCTAACCATTATTTGGGAACAAAGAGAGTTTTCATCTTTTTTCAGATCAAAACCATTCTGTAAAATCTTTGTTGTTTAAT
TAAATGTGCCGTTATTTACCCCTGATGTTATTTATGACTATGTGCCGATTCCTGCTCGGGCTGTTTGCTGTTGGCTGGTAATAATATATT
TGATTTAAATGCTGTTGACTGTGCTATTAACTGCTGCCGTCAGTAAACTCCAAAGATCTTTTTGTTTTGGCTTTAGTATCATATGTGCTT
TTTCTGTATCCTGAGCGCTCTATATGATCATGTTAATTTAAAGCTTTATACACATTGTTGTTTTTGCTGGTCTCATCTTTGGTAATATGC
TATACCCCACTGCTGCCCGACACTGCCCTTTAGCTGCAGAGCTGGATTAGCTGTTGACCATTTGATGCTGTTGTCTGTCTGGCAGGGACT
GAATGACCTGATGTCAGATTTAGATTCTTCCTGGGGATTACACAGCTATGAATGTATTTGCTTCTAAAACCTCCCAAAGTGAATCTAATC
TTAAAACTACAAGTTGTAAGTATTCTGAAATTGGGAAACATTTATTTTAAATGCAATCAGGTAGTGTTGCTTTTTACAGCATAATAAATA

>98587_98587_1_VTI1A-GLS_VTI1A_chr10_114224416_ENST00000393077_GLS_chr2_191792032_ENST00000320717_length(amino acids)=351AA_BP=98
MAWATRSGAAMSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQE
MGKLETDFLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGM
MCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRT

--------------------------------------------------------------
>98587_98587_2_VTI1A-GLS_VTI1A_chr10_114224416_ENST00000393077_GLS_chr2_191792032_ENST00000338435_length(transcript)=3356nt_BP=380nt
CCGTTCTGCTCTCGGGGGCACCTTCCGGGGTTCCTAAGCCGCGGGGCCCCTCGCTGCCCCTCGAGGCCCTTTCCCTGACCTAGGCTTTGG
CCTGGGCTACTCGTTCCGGAGCCGCCATGTCGTCCGACTTCGAAGGTTACGAGCAGGACTTCGCGGTGCTCACTGCAGAGATCACCAGCA
AGATTGCGAGGGTCCCACGACTCCCGCCTGATGAAAAGAAACAGATGGTTGCAAATGTGGAGAAACAGCTTGAAGAAGCGAAAGAACTGC
TTGAACAGATGGATTTGGAAGTCCGAGAGATACCACCCCAAAGTCGAGGGATGTACAGCAACAGAATGAGAAGCTACAAACAAGAAATGG
GAAAACTCGAAACAGATTTTCTGTGCTCCATTGAAGTGACTTGTGAATCAGCCAGTGTGATGGCTGCGACACTGGCTAATGGTGGTTTCT
GCCCAATTACTGGTGAAAGAGTACTGAGCCCTGAAGCAGTTCGAAATACATTGAGTTTGATGCATTCCTGTGGCATGTATGACTTCTCAG
GGCAGTTTGCTTTCCATGTTGGTCTTCCTGCAAAATCTGGAGTTGCTGGGGGCATTCTTTTAGTTGTCCCCAATGTTATGGGTATGATGT
GCTGGTCTCCTCCTCTGGATAAGATGGGCAACAGTGTTAAGGGAATTCACTTTTGTCACGATCTTGTTTCTCTGTGTAATTTCCATAACT
ATGATAATTTGAGACACTTTGCAAAAAAACTTGATCCTCGAAGAGAAGGTGGTGATCAAAGGCATTCCTTTGGACCATTGGACTATGAAA
GTCTCCAACAAGAACTTGCTTTAAAAGAGACAGTATGGAAAAAAGTGTCACCTGAGTCAAATGAGGACATCTCTACAACTGTAGTATATA
GAATGGAAAGTCTGGGAGAGAAAAGCTAAAGAAATGGGTTCTAGTTTCAGAATGTTTCTTCATTTAATCTTTCAAACATCTTTAGCTTTT
TTTTGCAAGTTATAAATATTTATTTGAGGTATTTTTTGTTCTCAATCTTGGGTGCTGGAGCCATAAAGCTTTTTTTTCCTTTTAATCTTT
GTATAAAGGCAGTAGATTAAGAAGTGCATTTGTTGGTCTTTAAAAAGTATTTACAAGTACATAAATTTGCTTTATTTTTAAAAATACAAA
AAGGAAAAATTTAAATTTTTTTTGATGTAATTAAAATGTTAACTATGTGGTCAGATAATCCCATTTTACAATAGTAACAGAAAATTGTAA
TTCTTAGTTCTAAAATTCACAAATTAAACTCATAAGTTTTGTTGCATTTTGTTTTTTCTTTTCCATTTTTAAAACTAATGTGATGTCTTT
AGTGGCAATAGAAGGTACTTCTATGCTAAATACAAAACTAAAAAGGCAAAATAATGAACCCCAAATTATTTTATTTAAAATAGCAGTGGA
TTATAAAATTAGCTTGTGTTTACATTTATGCCATTTTTGGTGATAGATTGGCTTTACATTTTAAAAAATTTATTTAAAAATTTATCAAAT
GCTTTAAAATATGACTCCTACTTTTTTTATTTTGCAACTCCTCTGTTCTGTCAGAGTTGTTATATACAGGAGTGTCTTATGTTACTAAAA
CATTCCAGCCAAAGAATTTCAGATGTGAGATAATGATGTTTCATCAATAAAAAGCTATAATGGTTAGTTACTCAGAAGGAGAAACAGTGA
GTGTCTTCAAGTGAATTGTTCACCTAAACAATTTTATTTTCATATTATCCACATAACTTTTTCTATGTTATATTTAAATATGAATGGCAA
ATTTTGGTTTTTAGCTTTTACATTTTATTATCTTAATTTTATAAATGCTAATATTTCTTTTGTGATAAGTTATAGCATCTCATAAAGTTT
GTTCTATTTGAAGTTTTTTAGAGTACTTGAGAAATGAATTTAGTCTGCAGGTAGTAAGTATGCTACTAAAATACGTTAGATCTAAATCCT
TTTATTTGGTATAAAAATGCAATATTGAGAATCAAAACTTGTTTTTAAGAGAACTATAGATTCTACACAACCTGATTTCAAGTAATTATT
CATAGTATTTATAGTTGTCTTGGCAAAGTGATTGTAAAATTCTGTAGGACCTATTCACACTTCTTCCTTCTTCCATATACTTCTCTGGTT
TTCCCCATAGTTCCCCTATAATTTCAAGTTTGTTGAAACCTGTTAATTTTAGTGGGGGATTAGAAGAAAAACTTGGTGGTTTCTTAGCAT
GATGGTGTATGTATGTGGTAATGGAAAGTCTGTAAAAGTAAATATAGTGTAGCAAAAAAGATTTCACTGAGTATTTTAGATACTAGTGCA
AATAAAGATAGAAAATCTTGATCATAATGTCTTAAGTTTGGGAACTGTGATATTAAGAAAAGAAATTCCCTTCTAGAGGTGCTGGCCAAA
AAGCCTTTTGGGCTAACTTAAGTATTAAATTTATATATTTAAATAATTATATTTTAAGTTGTAGAGGATTTTCCCAAGGATTTTATGCTT
ACTTGAATGTTCTTTGAATGTTCAGATGCATATCCTAACTGGATGCTTCTCAAGGCCTTACTGCATATTTGTGTTGCATATTTATGTTAG
TTGCACCAGGGCCATTTGTAGTTTGGGCAACCGAATGCCTTAATTGGAAAAAAGGCATTGTGGTTTCCCCTATGATCTAAATTGTTACAT
TTTACCATTTCATTCCGAAGTTGGTTTTACTTTATTAAATGAAGATTTAGTTTTCATATCGTATACATAGCTGTATAGATTTCAAAATTA
GGTTGTTAATTTGTGTCACTTACTATTTTTGTGTTGGTAATGCTTTAAATGCATACTTAAAAATGAAGTACTGTTATCTAAGCTACTGTG
TTTAGAAAATGTTAAGAATGAGCAGAAATTTTTATAGAAAAGTATAAACGGAAGAAGAGATAAGATACTGCGAATAGGCCCTCAAACTTA
AAAAAGAAAAAACTTTGCCAGTTTTAAGGACATATTTTGATTCTTTCAGTATTCTTAACACCTTTTTAAACAAAGTTCTTGATAGTACCC
ACTATTATTGGGTTTGTTTTATGCCATTATTGATTCTTGATATTCAAGCATTTACAATGTAGCATATTTGATTTTCTTTTTTCTTTCTTT
TTTTGGCATCATTAACATTTCATTTGAAATGCATATTGTTCTTGAAGTACTTTGTTTTTAGCATAAATGTTGTGCATTTTATCTTAGTGT
TTGGATGAAAACATTTGTGTTGTTTAGCTTTCATTTGCTTTGTATATTTAATAATGTACCTTTATTTTCCAGTATGCCTACATTTTGTAT

>98587_98587_2_VTI1A-GLS_VTI1A_chr10_114224416_ENST00000393077_GLS_chr2_191792032_ENST00000338435_length(amino acids)=280AA_BP=98
MAWATRSGAAMSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQE
MGKLETDFLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGM
MCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRHSFGPLDYESLQQELALKETVWKKVSPESNEDISTTVV

--------------------------------------------------------------
>98587_98587_3_VTI1A-GLS_VTI1A_chr10_114224416_ENST00000432306_GLS_chr2_191792032_ENST00000320717_length(transcript)=3708nt_BP=380nt
CCGTTCTGCTCTCGGGGGCACCTTCCGGGGTTCCTAAGCCGCGGGGCCCCTCGCTGCCCCTCGAGGCCCTTTCCCTGACCTAGGCTTTGG
CCTGGGCTACTCGTTCCGGAGCCGCCATGTCGTCCGACTTCGAAGGTTACGAGCAGGACTTCGCGGTGCTCACTGCAGAGATCACCAGCA
AGATTGCGAGGGTCCCACGACTCCCGCCTGATGAAAAGAAACAGATGGTTGCAAATGTGGAGAAACAGCTTGAAGAAGCGAAAGAACTGC
TTGAACAGATGGATTTGGAAGTCCGAGAGATACCACCCCAAAGTCGAGGGATGTACAGCAACAGAATGAGAAGCTACAAACAAGAAATGG
GAAAACTCGAAACAGATTTTCTGTGCTCCATTGAAGTGACTTGTGAATCAGCCAGTGTGATGGCTGCGACACTGGCTAATGGTGGTTTCT
GCCCAATTACTGGTGAAAGAGTACTGAGCCCTGAAGCAGTTCGAAATACATTGAGTTTGATGCATTCCTGTGGCATGTATGACTTCTCAG
GGCAGTTTGCTTTCCATGTTGGTCTTCCTGCAAAATCTGGAGTTGCTGGGGGCATTCTTTTAGTTGTCCCCAATGTTATGGGTATGATGT
GCTGGTCTCCTCCTCTGGATAAGATGGGCAACAGTGTTAAGGGAATTCACTTTTGTCACGATCTTGTTTCTCTGTGTAATTTCCATAACT
ATGATAATTTGAGACACTTTGCAAAAAAACTTGATCCTCGAAGAGAAGGTGGTGATCAAAGGGTAAAGTCAGTGATAAATCTTTTGTTTG
CTGCATATACTGGAGATGTGTCTGCACTTCGAAGATTTGCTTTGTCAGCTATGGACATGGAACAGCGGGACTATGATTCTAGAACAGCAC
TCCATGTAGCTGCTGCAGAGGGTCATGTTGAAGTTGTTAAATTTTTGCTGGAAGCCTGCAAAGTAAACCCTTTCCCCAAGGACAGGTGGA
ATAACACTCCCATGGATGAAGCACTGCACTTTGGACACCATGATGTATTTAAAATTCTCCAAGAATACCAAGTCCAGTACACACCTCAAG
GAGATTCTGACAACGGGAAGGAAAATCAAACCGTCCATAAGAATCTTGATGGATTGTTGTAATGGTCTCAAATCCCAAGATTTAAATCAC
TTACCTATTTAATTGTGGAAAATGATTATGAAGAACATGTGTATTTCTATCTGGTAGTGATGTATATTTTACATTTGTCATTTCAGTGTT
ACTGGAGTTTTCTTCATTGTGCACACAGGACAAATCTGATCTCTTTGGGAAAAAATAGAAATAAAACAATCTCCCTCCATAATGTGAGCA
ATATTACCTCGTGCATTGTATAATTTGATGTAAAAGAAATAGTTACCAATGCTAGCTTGTGTGGTCTTCCATGATTTATTTGTGTTTTGT
GAATTTTCAATTTATGGTGATGATCTGCTGATATGCATTTATAAAGTAAGCTCTGTTGTACAGTCTGTCCAAATGGGTCAAGGTTGCCTT
TAGAAGCAAATAGTGTGATTTTCAAGACTTCAAATACAAATTTAGTTTAAGTGTTTGAACAACTATATGCACTTACGGTTGTGTGTTTAA
AATGTCTCTCTCACCCCCTAGCTTCATGATGTGACTCTTAAAAAACTATAATAGTTAACAACTGTTAGTAAGATAGACCAATTCTGATTA
GACTTTATCAGGGAATCTGTTTAAGATATGTTTGGTGACCAAAACGTATGTGTGAATGTAGTTATAATGCTTTTGAAAAATTTTCCTTTT
TCTATATCCCCTTAGTCCAGCCTCTCTTCTCAGACATTTAGCTATCTGCCTCTTTCCTTTAGCTGGGAAAGTGAGAGCTGGCATACTATG
CAGTTTTTATGTTTTCCATAGTAAGTCAGAAAATGCCTCCTATTTCTGGCATCAGAACTTTGCCATTTGTCTACAGAAGACGAACCAGAG
ACAAAATTACTAAGTATAAATTAGTCAAGTTTATCAGTCTAAAAAACGAAGGGATGTGCAACTGCAGCTCTTTAAGAAGTTTTTTTTTTT
TAGCTTCTAGGGTAAAGATAAATTCAGAAATGCTCTAAGCTACCAAAGTTATTCTGAAAGTATGGGAACTGCTACAACTAACAAACATTT
GTTTCCAAGCCTGTCATTAAGAGTCTGCATCAAGAGATTTGTCCTCCTTGGGGGACCACTGGATCATTCCAGATTTCTTGTGATTTTTCT
ATTGTGTAATTCTTGGTGGGCTCTGTAGTTTAATAATAAGAAAAAGGCCATTTCATTTTAAATTGTGACCTATAATTCTTTGTCTTGGGT
TGGTAATTCAGGATTCATTTGGAAAGTGGGTAAAAGGGGCTTCAAAAAACGGATAGAACAGGATTTTCTAGGAGTTACACATACATTTTA
TCCTGTCATACCTCGAGATAAAGTGGCATGTTAGTGAGGAGTTCTGATATTAAGCACACACACACATGCACACAAATGGACTTCTCTGAA
GCTGTGTTTAGTGAAATGAGCTCAAGTACATGAATGTTAGTTGTTATCACATACAGCAAATTCCTTTTTTTTTCTTTTTCTATGAGCACA
CTCTGCTGCTTCTAAACTTTACATGCCTGATGGCACCTTACTCCAGCAGCCTCCAGGTGCTTTCATTTTCACTTCCAGTCTAAGCCAGTG
GCTCCTGCCACTGCCCTCCCATTACCTAGATGGCACCTCCTTTGGTGAAACCACGGCCAATGTTCCTTAGCTGCACCAGGCCCGAAGCTG
TTCCCATGCTTGAGCTTCCATGGGGAGGATGCTGAGTGAGCAGTTTCCTACCCCGTGGATCTAGCAAGCCATGGAGACAGGTAGCATTTG
TAAGATGCTGCACAGGAGCAGCATTATCCCCAAAGATATTACAGGGTAGACACGTTTTAACTGAAATCAATCAAGATAACTTTATTCAAA
GAGCAGCCCGCTTTGTGTGACTAAAATGAAACAAGACAGTTGAATTGTGTGACTTGAAGATTACCAATGATTTTGAGGCTTTTCTATAAT
AAAAAGAGGTTCTAACCATTATTTGGGAACAAAGAGAGTTTTCATCTTTTTTCAGATCAAAACCATTCTGTAAAATCTTTGTTGTTTAAT
TAAATGTGCCGTTATTTACCCCTGATGTTATTTATGACTATGTGCCGATTCCTGCTCGGGCTGTTTGCTGTTGGCTGGTAATAATATATT
TGATTTAAATGCTGTTGACTGTGCTATTAACTGCTGCCGTCAGTAAACTCCAAAGATCTTTTTGTTTTGGCTTTAGTATCATATGTGCTT
TTTCTGTATCCTGAGCGCTCTATATGATCATGTTAATTTAAAGCTTTATACACATTGTTGTTTTTGCTGGTCTCATCTTTGGTAATATGC
TATACCCCACTGCTGCCCGACACTGCCCTTTAGCTGCAGAGCTGGATTAGCTGTTGACCATTTGATGCTGTTGTCTGTCTGGCAGGGACT
GAATGACCTGATGTCAGATTTAGATTCTTCCTGGGGATTACACAGCTATGAATGTATTTGCTTCTAAAACCTCCCAAAGTGAATCTAATC
TTAAAACTACAAGTTGTAAGTATTCTGAAATTGGGAAACATTTATTTTAAATGCAATCAGGTAGTGTTGCTTTTTACAGCATAATAAATA

>98587_98587_3_VTI1A-GLS_VTI1A_chr10_114224416_ENST00000432306_GLS_chr2_191792032_ENST00000320717_length(amino acids)=351AA_BP=98
MAWATRSGAAMSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQE
MGKLETDFLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGM
MCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRT

--------------------------------------------------------------
>98587_98587_4_VTI1A-GLS_VTI1A_chr10_114224416_ENST00000432306_GLS_chr2_191792032_ENST00000338435_length(transcript)=3356nt_BP=380nt
CCGTTCTGCTCTCGGGGGCACCTTCCGGGGTTCCTAAGCCGCGGGGCCCCTCGCTGCCCCTCGAGGCCCTTTCCCTGACCTAGGCTTTGG
CCTGGGCTACTCGTTCCGGAGCCGCCATGTCGTCCGACTTCGAAGGTTACGAGCAGGACTTCGCGGTGCTCACTGCAGAGATCACCAGCA
AGATTGCGAGGGTCCCACGACTCCCGCCTGATGAAAAGAAACAGATGGTTGCAAATGTGGAGAAACAGCTTGAAGAAGCGAAAGAACTGC
TTGAACAGATGGATTTGGAAGTCCGAGAGATACCACCCCAAAGTCGAGGGATGTACAGCAACAGAATGAGAAGCTACAAACAAGAAATGG
GAAAACTCGAAACAGATTTTCTGTGCTCCATTGAAGTGACTTGTGAATCAGCCAGTGTGATGGCTGCGACACTGGCTAATGGTGGTTTCT
GCCCAATTACTGGTGAAAGAGTACTGAGCCCTGAAGCAGTTCGAAATACATTGAGTTTGATGCATTCCTGTGGCATGTATGACTTCTCAG
GGCAGTTTGCTTTCCATGTTGGTCTTCCTGCAAAATCTGGAGTTGCTGGGGGCATTCTTTTAGTTGTCCCCAATGTTATGGGTATGATGT
GCTGGTCTCCTCCTCTGGATAAGATGGGCAACAGTGTTAAGGGAATTCACTTTTGTCACGATCTTGTTTCTCTGTGTAATTTCCATAACT
ATGATAATTTGAGACACTTTGCAAAAAAACTTGATCCTCGAAGAGAAGGTGGTGATCAAAGGCATTCCTTTGGACCATTGGACTATGAAA
GTCTCCAACAAGAACTTGCTTTAAAAGAGACAGTATGGAAAAAAGTGTCACCTGAGTCAAATGAGGACATCTCTACAACTGTAGTATATA
GAATGGAAAGTCTGGGAGAGAAAAGCTAAAGAAATGGGTTCTAGTTTCAGAATGTTTCTTCATTTAATCTTTCAAACATCTTTAGCTTTT
TTTTGCAAGTTATAAATATTTATTTGAGGTATTTTTTGTTCTCAATCTTGGGTGCTGGAGCCATAAAGCTTTTTTTTCCTTTTAATCTTT
GTATAAAGGCAGTAGATTAAGAAGTGCATTTGTTGGTCTTTAAAAAGTATTTACAAGTACATAAATTTGCTTTATTTTTAAAAATACAAA
AAGGAAAAATTTAAATTTTTTTTGATGTAATTAAAATGTTAACTATGTGGTCAGATAATCCCATTTTACAATAGTAACAGAAAATTGTAA
TTCTTAGTTCTAAAATTCACAAATTAAACTCATAAGTTTTGTTGCATTTTGTTTTTTCTTTTCCATTTTTAAAACTAATGTGATGTCTTT
AGTGGCAATAGAAGGTACTTCTATGCTAAATACAAAACTAAAAAGGCAAAATAATGAACCCCAAATTATTTTATTTAAAATAGCAGTGGA
TTATAAAATTAGCTTGTGTTTACATTTATGCCATTTTTGGTGATAGATTGGCTTTACATTTTAAAAAATTTATTTAAAAATTTATCAAAT
GCTTTAAAATATGACTCCTACTTTTTTTATTTTGCAACTCCTCTGTTCTGTCAGAGTTGTTATATACAGGAGTGTCTTATGTTACTAAAA
CATTCCAGCCAAAGAATTTCAGATGTGAGATAATGATGTTTCATCAATAAAAAGCTATAATGGTTAGTTACTCAGAAGGAGAAACAGTGA
GTGTCTTCAAGTGAATTGTTCACCTAAACAATTTTATTTTCATATTATCCACATAACTTTTTCTATGTTATATTTAAATATGAATGGCAA
ATTTTGGTTTTTAGCTTTTACATTTTATTATCTTAATTTTATAAATGCTAATATTTCTTTTGTGATAAGTTATAGCATCTCATAAAGTTT
GTTCTATTTGAAGTTTTTTAGAGTACTTGAGAAATGAATTTAGTCTGCAGGTAGTAAGTATGCTACTAAAATACGTTAGATCTAAATCCT
TTTATTTGGTATAAAAATGCAATATTGAGAATCAAAACTTGTTTTTAAGAGAACTATAGATTCTACACAACCTGATTTCAAGTAATTATT
CATAGTATTTATAGTTGTCTTGGCAAAGTGATTGTAAAATTCTGTAGGACCTATTCACACTTCTTCCTTCTTCCATATACTTCTCTGGTT
TTCCCCATAGTTCCCCTATAATTTCAAGTTTGTTGAAACCTGTTAATTTTAGTGGGGGATTAGAAGAAAAACTTGGTGGTTTCTTAGCAT
GATGGTGTATGTATGTGGTAATGGAAAGTCTGTAAAAGTAAATATAGTGTAGCAAAAAAGATTTCACTGAGTATTTTAGATACTAGTGCA
AATAAAGATAGAAAATCTTGATCATAATGTCTTAAGTTTGGGAACTGTGATATTAAGAAAAGAAATTCCCTTCTAGAGGTGCTGGCCAAA
AAGCCTTTTGGGCTAACTTAAGTATTAAATTTATATATTTAAATAATTATATTTTAAGTTGTAGAGGATTTTCCCAAGGATTTTATGCTT
ACTTGAATGTTCTTTGAATGTTCAGATGCATATCCTAACTGGATGCTTCTCAAGGCCTTACTGCATATTTGTGTTGCATATTTATGTTAG
TTGCACCAGGGCCATTTGTAGTTTGGGCAACCGAATGCCTTAATTGGAAAAAAGGCATTGTGGTTTCCCCTATGATCTAAATTGTTACAT
TTTACCATTTCATTCCGAAGTTGGTTTTACTTTATTAAATGAAGATTTAGTTTTCATATCGTATACATAGCTGTATAGATTTCAAAATTA
GGTTGTTAATTTGTGTCACTTACTATTTTTGTGTTGGTAATGCTTTAAATGCATACTTAAAAATGAAGTACTGTTATCTAAGCTACTGTG
TTTAGAAAATGTTAAGAATGAGCAGAAATTTTTATAGAAAAGTATAAACGGAAGAAGAGATAAGATACTGCGAATAGGCCCTCAAACTTA
AAAAAGAAAAAACTTTGCCAGTTTTAAGGACATATTTTGATTCTTTCAGTATTCTTAACACCTTTTTAAACAAAGTTCTTGATAGTACCC
ACTATTATTGGGTTTGTTTTATGCCATTATTGATTCTTGATATTCAAGCATTTACAATGTAGCATATTTGATTTTCTTTTTTCTTTCTTT
TTTTGGCATCATTAACATTTCATTTGAAATGCATATTGTTCTTGAAGTACTTTGTTTTTAGCATAAATGTTGTGCATTTTATCTTAGTGT
TTGGATGAAAACATTTGTGTTGTTTAGCTTTCATTTGCTTTGTATATTTAATAATGTACCTTTATTTTCCAGTATGCCTACATTTTGTAT

>98587_98587_4_VTI1A-GLS_VTI1A_chr10_114224416_ENST00000432306_GLS_chr2_191792032_ENST00000338435_length(amino acids)=280AA_BP=98
MAWATRSGAAMSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQE
MGKLETDFLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGM
MCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRHSFGPLDYESLQQELALKETVWKKVSPESNEDISTTVV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for VTI1A-GLS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VTI1A-GLS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VTI1A-GLS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource