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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VWF-ZC3H14 (FusionGDB2 ID:98657)

Fusion Gene Summary for VWF-ZC3H14

check button Fusion gene summary
Fusion gene informationFusion gene name: VWF-ZC3H14
Fusion gene ID: 98657
HgeneTgene
Gene symbol

VWF

ZC3H14

Gene ID

7450

79882

Gene namevon Willebrand factorzinc finger CCCH-type containing 14
SynonymsF8VWF|VWDMRT56|MSUT-2|NY-REN-37|SUT2|UKp68
Cytomap

12p13.31

14q31.3

Type of geneprotein-codingprotein-coding
Descriptionvon Willebrand factorcoagulation factor VIII VWFzinc finger CCCH domain-containing protein 14mammalian suppressor of tau pathology-2nuclear protein UKp68renal carcinoma antigen NY-REN-37
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261405, ENST00000545906, 
ENST00000572068, 		ENST00000557605, 
ENST00000318308, ENST00000406216, 
ENST00000555900, ENST00000251038, 
ENST00000302216, ENST00000336693, 
ENST00000359301, ENST00000393514, 
ENST00000555755, ENST00000556945, 
ENST00000557607, 
Fusion gene scores* DoF score7 X 7 X 4=1967 X 7 X 4=196
# samples 87
** MAII scorelog2(8/196*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VWF [Title/Abstract] AND ZC3H14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVWF(6204626)-ZC3H14(89041037), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneVWF

GO:0007155

cell adhesion

10764791

HgeneVWF

GO:0030168

platelet activation

8565074

HgeneVWF

GO:0031589

cell-substrate adhesion

9079671


check buttonFusion gene breakpoints across VWF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZC3H14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0BJ-01AVWFchr12

6204626

-ZC3H14chr14

89041037

+


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Fusion Gene ORF analysis for VWF-ZC3H14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000261405ENST00000557605VWFchr12

6204626

-ZC3H14chr14

89041037

+
5CDS-intronENST00000261405ENST00000318308VWFchr12

6204626

-ZC3H14chr14

89041037

+
5CDS-intronENST00000261405ENST00000406216VWFchr12

6204626

-ZC3H14chr14

89041037

+
5CDS-intronENST00000261405ENST00000555900VWFchr12

6204626

-ZC3H14chr14

89041037

+
In-frameENST00000261405ENST00000251038VWFchr12

6204626

-ZC3H14chr14

89041037

+
In-frameENST00000261405ENST00000302216VWFchr12

6204626

-ZC3H14chr14

89041037

+
In-frameENST00000261405ENST00000336693VWFchr12

6204626

-ZC3H14chr14

89041037

+
In-frameENST00000261405ENST00000359301VWFchr12

6204626

-ZC3H14chr14

89041037

+
In-frameENST00000261405ENST00000393514VWFchr12

6204626

-ZC3H14chr14

89041037

+
In-frameENST00000261405ENST00000555755VWFchr12

6204626

-ZC3H14chr14

89041037

+
In-frameENST00000261405ENST00000556945VWFchr12

6204626

-ZC3H14chr14

89041037

+
In-frameENST00000261405ENST00000557607VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000545906ENST00000251038VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000545906ENST00000302216VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000545906ENST00000336693VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000545906ENST00000359301VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000545906ENST00000393514VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000545906ENST00000555755VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000545906ENST00000556945VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000545906ENST00000557607VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000572068ENST00000251038VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000572068ENST00000302216VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000572068ENST00000336693VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000572068ENST00000359301VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000572068ENST00000393514VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000572068ENST00000555755VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000572068ENST00000556945VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3CDSENST00000572068ENST00000557607VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3UTRENST00000545906ENST00000557605VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-3UTRENST00000572068ENST00000557605VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-intronENST00000545906ENST00000318308VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-intronENST00000545906ENST00000406216VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-intronENST00000545906ENST00000555900VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-intronENST00000572068ENST00000318308VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-intronENST00000572068ENST00000406216VWFchr12

6204626

-ZC3H14chr14

89041037

+
intron-intronENST00000572068ENST00000555900VWFchr12

6204626

-ZC3H14chr14

89041037

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261405VWFchr126204626-ENST00000359301ZC3H14chr1489041037+36269122431868541
ENST00000261405VWFchr126204626-ENST00000251038ZC3H14chr1489041037+40209122432261672
ENST00000261405VWFchr126204626-ENST00000302216ZC3H14chr1489041037+24479122431790515
ENST00000261405VWFchr126204626-ENST00000556945ZC3H14chr1489041037+20029122431868541
ENST00000261405VWFchr126204626-ENST00000557607ZC3H14chr1489041037+20299122431778511
ENST00000261405VWFchr126204626-ENST00000555755ZC3H14chr1489041037+24849122432243666
ENST00000261405VWFchr126204626-ENST00000393514ZC3H14chr1489041037+22469122432186647
ENST00000261405VWFchr126204626-ENST00000336693ZC3H14chr1489041037+19859122431868541

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261405ENST00000359301VWFchr126204626-ZC3H14chr1489041037+0.0003223810.99967766
ENST00000261405ENST00000251038VWFchr126204626-ZC3H14chr1489041037+0.0004327470.9995672
ENST00000261405ENST00000302216VWFchr126204626-ZC3H14chr1489041037+0.0005642110.9994357
ENST00000261405ENST00000556945VWFchr126204626-ZC3H14chr1489041037+0.003567250.9964328
ENST00000261405ENST00000557607VWFchr126204626-ZC3H14chr1489041037+0.0010996450.9989003
ENST00000261405ENST00000555755VWFchr126204626-ZC3H14chr1489041037+0.0029398850.9970601
ENST00000261405ENST00000393514VWFchr126204626-ZC3H14chr1489041037+0.003577910.9964222
ENST00000261405ENST00000336693VWFchr126204626-ZC3H14chr1489041037+0.0035452330.99645483

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Fusion Genomic Features for VWF-ZC3H14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
VWFchr126204625-ZC3H14chr1489041036+0.0161431230.9838569
VWFchr126204625-ZC3H14chr1489041036+0.0161431230.9838569

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for VWF-ZC3H14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:6204626/chr14:89041037)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZC3H14chr12:6204626chr14:89041037ENST00000251038517595_620287737.0Zinc fingerC3H1-type 1
TgeneZC3H14chr12:6204626chr14:89041037ENST00000251038517621_640287737.0Zinc fingerC3H1-type 2
TgeneZC3H14chr12:6204626chr14:89041037ENST00000251038517641_656287737.0Zinc fingerC3H1-type 3
TgeneZC3H14chr12:6204626chr14:89041037ENST00000251038517682_699287737.0Zinc fingerC3H1-type 4
TgeneZC3H14chr12:6204626chr14:89041037ENST00000251038517701_719287737.0Zinc fingerC3H1-type 5
TgeneZC3H14chr12:6204626chr14:89041037ENST00000302216514595_620287580.0Zinc fingerC3H1-type 1
TgeneZC3H14chr12:6204626chr14:89041037ENST00000302216514621_640287580.0Zinc fingerC3H1-type 2
TgeneZC3H14chr12:6204626chr14:89041037ENST00000302216514641_656287580.0Zinc fingerC3H1-type 3
TgeneZC3H14chr12:6204626chr14:89041037ENST00000302216514682_699287580.0Zinc fingerC3H1-type 4
TgeneZC3H14chr12:6204626chr14:89041037ENST00000302216514701_719287580.0Zinc fingerC3H1-type 5
TgeneZC3H14chr12:6204626chr14:89041037ENST0000031830807595_6200307.0Zinc fingerC3H1-type 1
TgeneZC3H14chr12:6204626chr14:89041037ENST0000031830807621_6400307.0Zinc fingerC3H1-type 2
TgeneZC3H14chr12:6204626chr14:89041037ENST0000031830807641_6560307.0Zinc fingerC3H1-type 3
TgeneZC3H14chr12:6204626chr14:89041037ENST0000031830807682_6990307.0Zinc fingerC3H1-type 4
TgeneZC3H14chr12:6204626chr14:89041037ENST0000031830807701_7190307.0Zinc fingerC3H1-type 5
TgeneZC3H14chr12:6204626chr14:89041037ENST00000336693515595_620253572.0Zinc fingerC3H1-type 1
TgeneZC3H14chr12:6204626chr14:89041037ENST00000336693515621_640253572.0Zinc fingerC3H1-type 2
TgeneZC3H14chr12:6204626chr14:89041037ENST00000336693515641_656253572.0Zinc fingerC3H1-type 3
TgeneZC3H14chr12:6204626chr14:89041037ENST00000336693515682_699253572.0Zinc fingerC3H1-type 4
TgeneZC3H14chr12:6204626chr14:89041037ENST00000336693515701_719253572.0Zinc fingerC3H1-type 5
TgeneZC3H14chr12:6204626chr14:89041037ENST00000359301515595_620253572.0Zinc fingerC3H1-type 1
TgeneZC3H14chr12:6204626chr14:89041037ENST00000359301515621_640253572.0Zinc fingerC3H1-type 2
TgeneZC3H14chr12:6204626chr14:89041037ENST00000359301515641_656253572.0Zinc fingerC3H1-type 3
TgeneZC3H14chr12:6204626chr14:89041037ENST00000359301515682_699253572.0Zinc fingerC3H1-type 4
TgeneZC3H14chr12:6204626chr14:89041037ENST00000359301515701_719253572.0Zinc fingerC3H1-type 5
TgeneZC3H14chr12:6204626chr14:89041037ENST00000393514516595_620287712.0Zinc fingerC3H1-type 1
TgeneZC3H14chr12:6204626chr14:89041037ENST00000393514516621_640287712.0Zinc fingerC3H1-type 2
TgeneZC3H14chr12:6204626chr14:89041037ENST00000393514516641_656287712.0Zinc fingerC3H1-type 3
TgeneZC3H14chr12:6204626chr14:89041037ENST00000393514516682_699287712.0Zinc fingerC3H1-type 4
TgeneZC3H14chr12:6204626chr14:89041037ENST00000393514516701_719287712.0Zinc fingerC3H1-type 5
TgeneZC3H14chr12:6204626chr14:89041037ENST0000040621606595_6200283.0Zinc fingerC3H1-type 1
TgeneZC3H14chr12:6204626chr14:89041037ENST0000040621606621_6400283.0Zinc fingerC3H1-type 2
TgeneZC3H14chr12:6204626chr14:89041037ENST0000040621606641_6560283.0Zinc fingerC3H1-type 3
TgeneZC3H14chr12:6204626chr14:89041037ENST0000040621606682_6990283.0Zinc fingerC3H1-type 4
TgeneZC3H14chr12:6204626chr14:89041037ENST0000040621606701_7190283.0Zinc fingerC3H1-type 5
TgeneZC3H14chr12:6204626chr14:89041037ENST00000555755517595_620287731.0Zinc fingerC3H1-type 1
TgeneZC3H14chr12:6204626chr14:89041037ENST00000555755517621_640287731.0Zinc fingerC3H1-type 2
TgeneZC3H14chr12:6204626chr14:89041037ENST00000555755517641_656287731.0Zinc fingerC3H1-type 3
TgeneZC3H14chr12:6204626chr14:89041037ENST00000555755517682_699287731.0Zinc fingerC3H1-type 4
TgeneZC3H14chr12:6204626chr14:89041037ENST00000555755517701_719287731.0Zinc fingerC3H1-type 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-6521146_11962192814.0DomainNote=TIL 4
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-6521277_14532192814.0DomainVWFA 1%3B binding site for platelet glycoprotein Ib
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-6521498_16652192814.0DomainVWFA 2
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-6521691_18712192814.0DomainVWFA 3%3B main binding site for collagens type I and III
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-6521949_21532192814.0DomainVWFD 4
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-6522255_23282192814.0DomainVWFC 1
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-6522429_24952192814.0DomainVWFC 2
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-6522580_26452192814.0DomainVWFC 3
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-6522724_28122192814.0DomainCTCK
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-652295_3482192814.0DomainNote=TIL 1
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-65234_2402192814.0DomainVWFD 1
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-652387_5982192814.0DomainVWFD 2
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-652652_7072192814.0DomainNote=TIL 2
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-652776_8272192814.0DomainNote=TIL 3
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-652866_10742192814.0DomainVWFD 3
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-6522507_25092192814.0MotifNote=Cell attachment site
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-6522216_22612192814.0RegionNote=E2
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-652764_7872192814.0RegionNote=Amino-terminal
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-652788_8332192814.0RegionNote=E1
HgeneVWFchr12:6204626chr14:89041037ENST00000261405-652826_8532192814.0RegionNote=CX


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Fusion Gene Sequence for VWF-ZC3H14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98657_98657_1_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000251038_length(transcript)=4020nt_BP=912nt
GTGGCAGCTCACAGCTATTGTGGTGGGAAAGGGAGGGTGGTTGGTGGATGTCACAGCTTGGGCTTTATCTCCCCCAGCAGTGGGGACTCC
ACAGCCCCTGGGCTACATAACAGCAAGACAGTCCGGAGCTGTAGCAGACCTGATTGAGCCTTTGCAGCAGCTGAGAGCATGGCCTAGGGT
GGGCGGCACCATTGTCCAGCAGCTGAGTTTCCCAGGGACCTTGGAGATAGCCGCAGCCCTCATTTGCAGGGGAAGATGATTCCTGCCAGA
TTTGCCGGGGTGCTGCTTGCTCTGGCCCTCATTTTGCCAGGGACCCTTTGTGCAGAAGGAACTCGCGGCAGGTCATCCACGGCCCGATGC
AGCCTTTTCGGAAGTGACTTCGTCAACACCTTTGATGGGAGCATGTACAGCTTTGCGGGATACTGCAGTTACCTCCTGGCAGGGGGCTGC
CAGAAACGCTCCTTCTCGATTATTGGGGACTTCCAGAATGGCAAGAGAGTGAGCCTCTCCGTGTATCTTGGGGAATTTTTTGACATCCAT
TTGTTTGTCAATGGTACCGTGACACAGGGGGACCAAAGAGTCTCCATGCCCTATGCCTCCAAAGGGCTGTATCTAGAAACTGAGGCTGGG
TACTACAAGCTGTCCGGTGAGGCCTATGGCTTTGTGGCCAGGATCGATGGCAGCGGCAACTTTCAAGTCCTGCTGTCAGACAGATACTTC
AACAAGACCTGCGGGCTGTGTGGCAACTTTAACATCTTTGCTGAAGATGACTTTATGACCCAAGAAGGGACCTTGACCTCGGACCCTTAT
GACTTTGCCAACTCATGGGCTCTGAGCAGTGGAGAACAGTGGTGTGAACGGGCATCTCCTCCCAGCAGCTCATGCAACATCTCCTCTGGG
GAAATGCAGAAGGATGAAAACTTTCGGAAGAGAAAGTTGCCTGTGGTAAGTTCAGTTGTTAAAGTAAAAAAATTCAATCATGATGGAGAA
GAGGAGGAAGAAGATGATGATTACGGGTCTCGAACAGGAAGCATCTCCAGCAGTGTGTCTGTGCCTGCAAAGCCTGAAAGGAGACCTTCT
CTTCCACCTTCTAAACAAGCTAACAAGAATCTGATTTTGAAGGCTATATCTGAAGCTCAAGAATCCGTAACAAAAACAACTAACTACTCT
ACAGTTCCACAGAAACAGACACTTCCAGTTGCTCCCAGAACTCGAACTTCTCAAGAAGAATTGCTAGCAGAAGTGGTCCAGGGACAAAGT
AGGACCCCCAGAATAAGTCCCCCCATTAAAGAAGAGGAAACAAAAGGAGATTCTGTAGAAAAAAATCAAGGAACTCAACAGAGGCAATTA
TTATCCCGACTGCAAATCGACCCAGTAATGGCAGAAACTCTGCAGATGAGTCAAGATTACTATGACATGGAATCCATGGTCCATGCAGAC
ACAAGATCATTTATTCTGAAGAAGCCAAAGCTGTCTGAGGAAGTAGTAGTGGCACCAAACCAAGAGTCGGGGATGAAGACTGCAGATTCC
CTTCGGGTACTTTCAGGACACCTTATGCAGACACGAGATCTTGTACAACCAGATAAACCTGCAAGTCCCAAGTTTATAGTGACGCTGGAT
GGTGTCCCCAGCCCCCCAGGATACATGTCAGATCAAGAGGAGGACATGTGCTTTGAAGGAATGAAACCCGTAAACCAAACTGCAGCCTCA
AACAAGGGACTCAGAGGTCTCCTCCACCCACAGCAGTTGCACTTGCTGAGCAGGCAGCTTGAGGACCCAAATGGTAGCTTTTCTAACGCT
GAGATGAGTGAACTGAGTGTGGCACAGAAACCAGAAAAACTTTTGGAGCGCTGCAAGTACTGGCCTGCTTGTAAAAATGGGGATGAGTGT
GCCTACCATCACCCCATCTCACCCTGCAAAGCCTTCCCCAATTGTAAATTTGCTGAAAAATGTTTGTTTGTTCACCCAAATTGTAAATAT
GATGCAAAGTGTACTAAACCAGATTGTCCCTTCACTCATGTGAGTAGAAGAATTCCAGTACTGTCTCCAAAACCAGCAGTTGCACCACCA
GCACCACCTTCCAGTAGTCAGCTCTGCCGTTACTTCCCTGCTTGTAAGAAGATGGAATGTCCCTTCTATCATCCAAAACATTGTAGGTTT
AACACTCAATGTACAAGACCGGACTGCACATTCTACCATCCCACCATTAATGTCCCACCACGACATGCCTTGAAATGGATTCGACCTCAA
ACCAGCGAATAGCACCCAGTCCTGCCTGGCAGAAGATCATGCAGTTTGGAAGTTTTCATGTACTGATGAAAGATACTCTACAGAACTTGT
CAAATCTTTGAAACTTGGAATATATTGCTTTCATAATATGAAGTTTTATTGCCTATCTATCTGAAGTGTCTAATTTTTCAAGTTTGTAAG
TTTATTATGTGGTTTTAACATTGGGTGTTTTTGTTTTGTTTTTACTATGAAAAGACAGCTTAAGGAAGAGCTAAATTCTGTTAAAATATT
TGGGGCATGTTTGTGCACTGCTGTTGTGAGGATCAGCATATGAAATTGACATCATGGTTAGTCATGGTACTGCAGCTTAGGGGGCTACAC
GGTTGCTGTGTGAGTGGAGAGATGCAGTGAGGCAGTTGTCATTATTCTAAAAATTGTACTACTTTCACTTTTCCCAAAGATTATATAATG
TTCATAATCCACCATGAAAACAGCATTGGCCAAAGGTACTGAGGCTGCTTAAAATATTCAATTCTGCTTTTTAATTTTTAAGTGAATTTA
GTTTGAAAAGCATGATTATACAGGCCTCTCAGGCTGAGTGCTACTTTGGTAAAGTTCCCAGTTTTCCTGCCTTCTGTGACAGGATGAATG
AGGTGGGTATGGACAGTGGAGGCAGCTGGAATGGCAAGTGCAGAAAATAGGAACAGTTCTATACAGTGCTCTCATTTACTAATAACATAA
TGCCTTCTAAATAATTTTTTTGGGAAACTACATTATCACAAAATTATACAAATTTTTTTACAAGTATTTACATACTGTATCTGAAAACAG
ACTTTAAAGTCACAAGATTATAAATGTACATATATATTCTCACATTCTGAAAAATAACATTCTCAGAATCCACAGAAAATATACTTAGTT
ACTACTGAAGATAATTTTTGAAATGTAAAAATTAGATTTAAATAGTATATTTTAAATGACAGAACTATAATTACAGAGATCAGATCAGAT
AGGTAAACTGCAAGATAGATAGGATGAAACTTTTGGCCTACTGTATTACTTACAGAGTTTTTTTGTGTGTGGTTTTTAAAACTGTTAAGG
CAAGAAGTGTCAAATGCTTTAGAGTTAAATAACAGATCACTGATTTCAAAGACTTGGTGTATAGTGTTAAAAATTAAAGCTTAAAAGGTG
GTTAGAAAAGTGGATTAATGCAAAAGGGGTAATAAAGACTGCAACATTCTCAGGACCAAATTAAACTGCTAAAAAAAAAAAAAAAGTTCA
TTGACTTGCTTAGTCGTATACTCAAATGATGATAAACCTACATGTGCAAAGGCTCACGTTTAAGATTGTCAAGCCAGCAGTCTACTGTTG
TGTTGCCATTGCTTTTCCATTGGGAGAAGAAAGAATTAACCAGTCATTAAACCATTTGGTAAGTTGCACTTTGCTGTGCTGATCCCACAG
GAAAGGCTTGAAACACGAGAAGCAGCAAAGACAGAGCACACAAGTGCATAAGGCTGTTGTCTTCGGCTTGGGTGAAATGACAGTTCCTCT
TCATTCTAAAGGTTTACTCCATTGAATTTAAGGCATTTGTTCATTCCAGTGTTGAGATGCTTTGCATCTCTGCAGAAGAAATTTATTTTA
AATTGTTTAAATATCTGGAAATACTTTTAGCTATCATTTATAAAGATAGTTTTGTTCTCAGTTTCACTATAAATTATAGAACAAATGGGA

>98657_98657_1_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000251038_length(amino acids)=672AA_BP=207
MQGKMIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGKRVSLSV
YLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQ
EGTLTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSV
PAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAEVVQGQSRTPRISPPIKEEETKGDSVEK
NQGTQQRQLLSRLQIDPVMAETLQMSQDYYDMESMVHADTRSFILKKPKLSEEVVVAPNQESGMKTADSLRVLSGHLMQTRDLVQPDKPA
SPKFIVTLDGVPSPPGYMSDQEEDMCFEGMKPVNQTAASNKGLRGLLHPQQLHLLSRQLEDPNGSFSNAEMSELSVAQKPEKLLERCKYW
PACKNGDECAYHHPISPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHVSRRIPVLSPKPAVAPPAPPSSSQLCRYFPACKKMECP

--------------------------------------------------------------
>98657_98657_2_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000302216_length(transcript)=2447nt_BP=912nt
GTGGCAGCTCACAGCTATTGTGGTGGGAAAGGGAGGGTGGTTGGTGGATGTCACAGCTTGGGCTTTATCTCCCCCAGCAGTGGGGACTCC
ACAGCCCCTGGGCTACATAACAGCAAGACAGTCCGGAGCTGTAGCAGACCTGATTGAGCCTTTGCAGCAGCTGAGAGCATGGCCTAGGGT
GGGCGGCACCATTGTCCAGCAGCTGAGTTTCCCAGGGACCTTGGAGATAGCCGCAGCCCTCATTTGCAGGGGAAGATGATTCCTGCCAGA
TTTGCCGGGGTGCTGCTTGCTCTGGCCCTCATTTTGCCAGGGACCCTTTGTGCAGAAGGAACTCGCGGCAGGTCATCCACGGCCCGATGC
AGCCTTTTCGGAAGTGACTTCGTCAACACCTTTGATGGGAGCATGTACAGCTTTGCGGGATACTGCAGTTACCTCCTGGCAGGGGGCTGC
CAGAAACGCTCCTTCTCGATTATTGGGGACTTCCAGAATGGCAAGAGAGTGAGCCTCTCCGTGTATCTTGGGGAATTTTTTGACATCCAT
TTGTTTGTCAATGGTACCGTGACACAGGGGGACCAAAGAGTCTCCATGCCCTATGCCTCCAAAGGGCTGTATCTAGAAACTGAGGCTGGG
TACTACAAGCTGTCCGGTGAGGCCTATGGCTTTGTGGCCAGGATCGATGGCAGCGGCAACTTTCAAGTCCTGCTGTCAGACAGATACTTC
AACAAGACCTGCGGGCTGTGTGGCAACTTTAACATCTTTGCTGAAGATGACTTTATGACCCAAGAAGGGACCTTGACCTCGGACCCTTAT
GACTTTGCCAACTCATGGGCTCTGAGCAGTGGAGAACAGTGGTGTGAACGGGCATCTCCTCCCAGCAGCTCATGCAACATCTCCTCTGGG
GAAATGCAGAAGGATGAAAACTTTCGGAAGAGAAAGTTGCCTGTGGTAAGTTCAGTTGTTAAAGTAAAAAAATTCAATCATGATGGAGAA
GAGGAGGAAGAAGATGATGATTACGGGTCTCGAACAGGAAGCATCTCCAGCAGTGTGTCTGTGCCTGCAAAGCCTGAAAGGAGACCTTCT
CTTCCACCTTCTAAACAAGCTAACAAGAATCTGATTTTGAAGGCTATATCTGAAGCTCAAGAATCCGTAACAAAAACAACTAACTACTCT
ACAGTTCCACAGAAACAGACACTTCCAGTTGCTCCCAGAACTCGAACTTCTCAAGAAGAATTGCTAGCAGAAGTGGTCCAGGGACAAAGT
AGGACCCCCAGAATAAGTCCCCCCATTAAAGAAGAGGAAACAAAAGGAGATTCTGTAGAAAAAAATCAAGCTGAGATGAGTGAACTGAGT
GTGGCACAGAAACCAGAAAAACTTTTGGAGCGCTGCAAGTACTGGCCTGCTTGTAAAAATGGGGATGAGTGTGCCTACCATCACCCCATC
TCACCCTGCAAAGCCTTCCCCAATTGTAAATTTGCTGAAAAATGTTTGTTTGTTCACCCAAATTGTAAATATGATGCAAAGTGTACTAAA
CCAGATTGTCCCTTCACTCATGTGAGTAGAAGAATTCCAGTACTGTCTCCAAAACCAGTTGCACCACCAGCACCACCTTCCAGTAGTCAG
CTCTGCCGTTACTTCCCTGCTTGTAAGAAGATGGAATGTCCCTTCTATCATCCAAAACATTGTAGGTTTAACACTCAATGTACAAGACCG
GACTGCACATTCTACCATCCCACCATTAATGTCCCACCACGACATGCCTTGAAATGGATTCGACCTCAAACCAGCGAATAGCACCCAGTC
CTGCCTGGCAGAAGATCATGCAGTTTGGAAGTTTTCATGTACTGATGAAAGATACTCTACAGAACTTGTCAAATCTTTGAAACTTGGAAT
ATATTGCTTTCATAATATGAAGTTTTATTGCCTATCTATCTGAAGTGTCTAATTTTTCAAGTTTGTAAGTTTATTATGTGGTTTTAACAT
TGGGTGTTTTTGTTTTGTTTTTACTATGAAAAGACAGCTTAAGGAAGAGCTAAATTCTGTTAAAATATTTGGGGCATGTTTGTGCACTGC
TGTTGTGAGGATCAGCATATGAAATTGACATCATGGTTAGTCATGGTACTGCAGCTTAGGGGGCTACACGGTTGCTGTGTGAGTGGAGAG
ATGCAGTGAGGCAGTTGTCATTATTCTAAAAATTGTACTACTTTCACTTTTCCCAAAGATTATATAATGTTCATAATCCACCATGAAAAC
AGCATTGGCCAAAGGTACTGAGGCTGCTTAAAATATTCAATTCTGCTTTTTAATTTTTAAGTGAATTTAGTTTGAAAAGCATGATTATAC
AGGCCTCTCAGGCTGAGTGCTACTTTGGTAAAGTTCCCAGTTTTCCTGCCTTCTGTGACAGGATGAATGAGGTGGGTATGGACAGTGGAG

>98657_98657_2_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000302216_length(amino acids)=515AA_BP=207
MQGKMIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGKRVSLSV
YLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQ
EGTLTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSV
PAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAEVVQGQSRTPRISPPIKEEETKGDSVEK
NQAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPISPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHVSRRIPVLSPKPVA

--------------------------------------------------------------
>98657_98657_3_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000336693_length(transcript)=1985nt_BP=912nt
GTGGCAGCTCACAGCTATTGTGGTGGGAAAGGGAGGGTGGTTGGTGGATGTCACAGCTTGGGCTTTATCTCCCCCAGCAGTGGGGACTCC
ACAGCCCCTGGGCTACATAACAGCAAGACAGTCCGGAGCTGTAGCAGACCTGATTGAGCCTTTGCAGCAGCTGAGAGCATGGCCTAGGGT
GGGCGGCACCATTGTCCAGCAGCTGAGTTTCCCAGGGACCTTGGAGATAGCCGCAGCCCTCATTTGCAGGGGAAGATGATTCCTGCCAGA
TTTGCCGGGGTGCTGCTTGCTCTGGCCCTCATTTTGCCAGGGACCCTTTGTGCAGAAGGAACTCGCGGCAGGTCATCCACGGCCCGATGC
AGCCTTTTCGGAAGTGACTTCGTCAACACCTTTGATGGGAGCATGTACAGCTTTGCGGGATACTGCAGTTACCTCCTGGCAGGGGGCTGC
CAGAAACGCTCCTTCTCGATTATTGGGGACTTCCAGAATGGCAAGAGAGTGAGCCTCTCCGTGTATCTTGGGGAATTTTTTGACATCCAT
TTGTTTGTCAATGGTACCGTGACACAGGGGGACCAAAGAGTCTCCATGCCCTATGCCTCCAAAGGGCTGTATCTAGAAACTGAGGCTGGG
TACTACAAGCTGTCCGGTGAGGCCTATGGCTTTGTGGCCAGGATCGATGGCAGCGGCAACTTTCAAGTCCTGCTGTCAGACAGATACTTC
AACAAGACCTGCGGGCTGTGTGGCAACTTTAACATCTTTGCTGAAGATGACTTTATGACCCAAGAAGGGACCTTGACCTCGGACCCTTAT
GACTTTGCCAACTCATGGGCTCTGAGCAGTGGAGAACAGTGGTGTGAACGGGCATCTCCTCCCAGCAGCTCATGCAACATCTCCTCTGGG
GAAATGCAGAAGGATGAAAACTTTCGGAAGAGAAAGTTGCCTGTGGTAAGTTCAGTTGTTAAAGTAAAAAAATTCAATCATGATGGAGAA
GAGGAGGAAGAAGATGATGATTACGGGTCTCGAACAGGAAGCATCTCCAGCAGTGTGTCTGTGCCTGCAAAGCCTGAAAGGAGACCTTCT
CTTCCACCTTCTAAACAAGCTAACAAGAATCTGATTTTGAAGGCTATATCTGAAGCTCAAGAATCCGTAACAAAAACAACTAACTACTCT
ACAGTTCCACAGAAACAGACACTTCCAGTTGCTCCCAGAACTCGAACTTCTCAAGAAGAATTGCTAGCAGAAGTGGTCCAGGGACAAAGT
AGGACCCCCAGAATAAGTCCCCCCATTAAAGAAGAGGAAACAAAAGGAGATTCTGTAGAAAAAAATCAAGGAACTCAACAGAGGCAATTA
TTATCCCGACTGCAAATCGACCCAGTAATGGCAGAAACTCTGCAGATGAGTCAAGCTGAGATGAGTGAACTGAGTGTGGCACAGAAACCA
GAAAAACTTTTGGAGCGCTGCAAGTACTGGCCTGCTTGTAAAAATGGGGATGAGTGTGCCTACCATCACCCCATCTCACCCTGCAAAGCC
TTCCCCAATTGTAAATTTGCTGAAAAATGTTTGTTTGTTCACCCAAATTGTAAATATGATGCAAAGTGTACTAAACCAGATTGTCCCTTC
ACTCATGTGAGTAGAAGAATTCCAGTACTGTCTCCAAAACCAGCAGTTGCACCACCAGCACCACCTTCCAGTAGTCAGCTCTGCCGTTAC
TTCCCTGCTTGTAAGAAGATGGAATGTCCCTTCTATCATCCAAAACATTGTAGGTTTAACACTCAATGTACAAGACCGGACTGCACATTC
TACCATCCCACCATTAATGTCCCACCACGACATGCCTTGAAATGGATTCGACCTCAAACCAGCGAATAGCACCCAGTCCTGCCTGGCAGA
AGATCATGCAGTTTGGAAGTTTTCATGTACTGATGAAAGATACTCTACAGAACTTGTCAAATCTTTGAAACTTGGAATATATTGCTTTCA

>98657_98657_3_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000336693_length(amino acids)=541AA_BP=207
MQGKMIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGKRVSLSV
YLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQ
EGTLTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSV
PAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAEVVQGQSRTPRISPPIKEEETKGDSVEK
NQGTQQRQLLSRLQIDPVMAETLQMSQAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPISPCKAFPNCKFAEKCLFVHPNCKYDA
KCTKPDCPFTHVSRRIPVLSPKPAVAPPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTINVPPRHALKWIRPQTS

--------------------------------------------------------------
>98657_98657_4_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000359301_length(transcript)=3626nt_BP=912nt
GTGGCAGCTCACAGCTATTGTGGTGGGAAAGGGAGGGTGGTTGGTGGATGTCACAGCTTGGGCTTTATCTCCCCCAGCAGTGGGGACTCC
ACAGCCCCTGGGCTACATAACAGCAAGACAGTCCGGAGCTGTAGCAGACCTGATTGAGCCTTTGCAGCAGCTGAGAGCATGGCCTAGGGT
GGGCGGCACCATTGTCCAGCAGCTGAGTTTCCCAGGGACCTTGGAGATAGCCGCAGCCCTCATTTGCAGGGGAAGATGATTCCTGCCAGA
TTTGCCGGGGTGCTGCTTGCTCTGGCCCTCATTTTGCCAGGGACCCTTTGTGCAGAAGGAACTCGCGGCAGGTCATCCACGGCCCGATGC
AGCCTTTTCGGAAGTGACTTCGTCAACACCTTTGATGGGAGCATGTACAGCTTTGCGGGATACTGCAGTTACCTCCTGGCAGGGGGCTGC
CAGAAACGCTCCTTCTCGATTATTGGGGACTTCCAGAATGGCAAGAGAGTGAGCCTCTCCGTGTATCTTGGGGAATTTTTTGACATCCAT
TTGTTTGTCAATGGTACCGTGACACAGGGGGACCAAAGAGTCTCCATGCCCTATGCCTCCAAAGGGCTGTATCTAGAAACTGAGGCTGGG
TACTACAAGCTGTCCGGTGAGGCCTATGGCTTTGTGGCCAGGATCGATGGCAGCGGCAACTTTCAAGTCCTGCTGTCAGACAGATACTTC
AACAAGACCTGCGGGCTGTGTGGCAACTTTAACATCTTTGCTGAAGATGACTTTATGACCCAAGAAGGGACCTTGACCTCGGACCCTTAT
GACTTTGCCAACTCATGGGCTCTGAGCAGTGGAGAACAGTGGTGTGAACGGGCATCTCCTCCCAGCAGCTCATGCAACATCTCCTCTGGG
GAAATGCAGAAGGATGAAAACTTTCGGAAGAGAAAGTTGCCTGTGGTAAGTTCAGTTGTTAAAGTAAAAAAATTCAATCATGATGGAGAA
GAGGAGGAAGAAGATGATGATTACGGGTCTCGAACAGGAAGCATCTCCAGCAGTGTGTCTGTGCCTGCAAAGCCTGAAAGGAGACCTTCT
CTTCCACCTTCTAAACAAGCTAACAAGAATCTGATTTTGAAGGCTATATCTGAAGCTCAAGAATCCGTAACAAAAACAACTAACTACTCT
ACAGTTCCACAGAAACAGACACTTCCAGTTGCTCCCAGAACTCGAACTTCTCAAGAAGAATTGCTAGCAGAAGTGGTCCAGGGACAAAGT
AGGACCCCCAGAATAAGTCCCCCCATTAAAGAAGAGGAAACAAAAGGAGATTCTGTAGAAAAAAATCAAGGAACTCAACAGAGGCAATTA
TTATCCCGACTGCAAATCGACCCAGTAATGGCAGAAACTCTGCAGATGAGTCAAGCTGAGATGAGTGAACTGAGTGTGGCACAGAAACCA
GAAAAACTTTTGGAGCGCTGCAAGTACTGGCCTGCTTGTAAAAATGGGGATGAGTGTGCCTACCATCACCCCATCTCACCCTGCAAAGCC
TTCCCCAATTGTAAATTTGCTGAAAAATGTTTGTTTGTTCACCCAAATTGTAAATATGATGCAAAGTGTACTAAACCAGATTGTCCCTTC
ACTCATGTGAGTAGAAGAATTCCAGTACTGTCTCCAAAACCAGCAGTTGCACCACCAGCACCACCTTCCAGTAGTCAGCTCTGCCGTTAC
TTCCCTGCTTGTAAGAAGATGGAATGTCCCTTCTATCATCCAAAACATTGTAGGTTTAACACTCAATGTACAAGACCGGACTGCACATTC
TACCATCCCACCATTAATGTCCCACCACGACATGCCTTGAAATGGATTCGACCTCAAACCAGCGAATAGCACCCAGTCCTGCCTGGCAGA
AGATCATGCAGTTTGGAAGTTTTCATGTACTGATGAAAGATACTCTACAGAACTTGTCAAATCTTTGAAACTTGGAATATATTGCTTTCA
TAATATGAAGTTTTATTGCCTATCTATCTGAAGTGTCTAATTTTTCAAGTTTGTAAGTTTATTATGTGGTTTTAACATTGGGTGTTTTTG
TTTTGTTTTTACTATGAAAAGACAGCTTAAGGAAGAGCTAAATTCTGTTAAAATATTTGGGGCATGTTTGTGCACTGCTGTTGTGAGGAT
CAGCATATGAAATTGACATCATGGTTAGTCATGGTACTGCAGCTTAGGGGGCTACACGGTTGCTGTGTGAGTGGAGAGATGCAGTGAGGC
AGTTGTCATTATTCTAAAAATTGTACTACTTTCACTTTTCCCAAAGATTATATAATGTTCATAATCCACCATGAAAACAGCATTGGCCAA
AGGTACTGAGGCTGCTTAAAATATTCAATTCTGCTTTTTAATTTTTAAGTGAATTTAGTTTGAAAAGCATGATTATACAGGCCTCTCAGG
CTGAGTGCTACTTTGGTAAAGTTCCCAGTTTTCCTGCCTTCTGTGACAGGATGAATGAGGTGGGTATGGACAGTGGAGGCAGCTGGAATG
GCAAGTGCAGAAAATAGGAACAGTTCTATACAGTGCTCTCATTTACTAATAACATAATGCCTTCTAAATAATTTTTTTGGGAAACTACAT
TATCACAAAATTATACAAATTTTTTTACAAGTATTTACATACTGTATCTGAAAACAGACTTTAAAGTCACAAGATTATAAATGTACATAT
ATATTCTCACATTCTGAAAAATAACATTCTCAGAATCCACAGAAAATATACTTAGTTACTACTGAAGATAATTTTTGAAATGTAAAAATT
AGATTTAAATAGTATATTTTAAATGACAGAACTATAATTACAGAGATCAGATCAGATAGGTAAACTGCAAGATAGATAGGATGAAACTTT
TGGCCTACTGTATTACTTACAGAGTTTTTTTGTGTGTGGTTTTTAAAACTGTTAAGGCAAGAAGTGTCAAATGCTTTAGAGTTAAATAAC
AGATCACTGATTTCAAAGACTTGGTGTATAGTGTTAAAAATTAAAGCTTAAAAGGTGGTTAGAAAAGTGGATTAATGCAAAAGGGGTAAT
AAAGACTGCAACATTCTCAGGACCAAATTAAACTGCTAAAAAAAAAAAAAAAGTTCATTGACTTGCTTAGTCGTATACTCAAATGATGAT
AAACCTACATGTGCAAAGGCTCACGTTTAAGATTGTCAAGCCAGCAGTCTACTGTTGTGTTGCCATTGCTTTTCCATTGGGAGAAGAAAG
AATTAACCAGTCATTAAACCATTTGGTAAGTTGCACTTTGCTGTGCTGATCCCACAGGAAAGGCTTGAAACACGAGAAGCAGCAAAGACA
GAGCACACAAGTGCATAAGGCTGTTGTCTTCGGCTTGGGTGAAATGACAGTTCCTCTTCATTCTAAAGGTTTACTCCATTGAATTTAAGG
CATTTGTTCATTCCAGTGTTGAGATGCTTTGCATCTCTGCAGAAGAAATTTATTTTAAATTGTTTAAATATCTGGAAATACTTTTAGCTA
TCATTTATAAAGATAGTTTTGTTCTCAGTTTCACTATAAATTATAGAACAAATGGGAAACAAGGGTTTAATTTAGTTCAGCCATTTTACA

>98657_98657_4_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000359301_length(amino acids)=541AA_BP=207
MQGKMIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGKRVSLSV
YLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQ
EGTLTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSV
PAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAEVVQGQSRTPRISPPIKEEETKGDSVEK
NQGTQQRQLLSRLQIDPVMAETLQMSQAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPISPCKAFPNCKFAEKCLFVHPNCKYDA
KCTKPDCPFTHVSRRIPVLSPKPAVAPPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTINVPPRHALKWIRPQTS

--------------------------------------------------------------
>98657_98657_5_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000393514_length(transcript)=2246nt_BP=912nt
GTGGCAGCTCACAGCTATTGTGGTGGGAAAGGGAGGGTGGTTGGTGGATGTCACAGCTTGGGCTTTATCTCCCCCAGCAGTGGGGACTCC
ACAGCCCCTGGGCTACATAACAGCAAGACAGTCCGGAGCTGTAGCAGACCTGATTGAGCCTTTGCAGCAGCTGAGAGCATGGCCTAGGGT
GGGCGGCACCATTGTCCAGCAGCTGAGTTTCCCAGGGACCTTGGAGATAGCCGCAGCCCTCATTTGCAGGGGAAGATGATTCCTGCCAGA
TTTGCCGGGGTGCTGCTTGCTCTGGCCCTCATTTTGCCAGGGACCCTTTGTGCAGAAGGAACTCGCGGCAGGTCATCCACGGCCCGATGC
AGCCTTTTCGGAAGTGACTTCGTCAACACCTTTGATGGGAGCATGTACAGCTTTGCGGGATACTGCAGTTACCTCCTGGCAGGGGGCTGC
CAGAAACGCTCCTTCTCGATTATTGGGGACTTCCAGAATGGCAAGAGAGTGAGCCTCTCCGTGTATCTTGGGGAATTTTTTGACATCCAT
TTGTTTGTCAATGGTACCGTGACACAGGGGGACCAAAGAGTCTCCATGCCCTATGCCTCCAAAGGGCTGTATCTAGAAACTGAGGCTGGG
TACTACAAGCTGTCCGGTGAGGCCTATGGCTTTGTGGCCAGGATCGATGGCAGCGGCAACTTTCAAGTCCTGCTGTCAGACAGATACTTC
AACAAGACCTGCGGGCTGTGTGGCAACTTTAACATCTTTGCTGAAGATGACTTTATGACCCAAGAAGGGACCTTGACCTCGGACCCTTAT
GACTTTGCCAACTCATGGGCTCTGAGCAGTGGAGAACAGTGGTGTGAACGGGCATCTCCTCCCAGCAGCTCATGCAACATCTCCTCTGGG
GAAATGCAGAAGGATGAAAACTTTCGGAAGAGAAAGTTGCCTGTGGTAAGTTCAGTTGTTAAAGTAAAAAAATTCAATCATGATGGAGAA
GAGGAGGAAGAAGATGATGATTACGGGTCTCGAACAGGAAGCATCTCCAGCAGTGTGTCTGTGCCTGCAAAGCCTGAAAGGAGACCTTCT
CTTCCACCTTCTAAACAAGCTAACAAGAATCTGATTTTGAAGGCTATATCTGAAGCTCAAGAATCCGTAACAAAAACAACTAACTACTCT
ACAGTTCCACAGAAACAGACACTTCCAGTTGCTCCCAGAACTCGAACTTCTCAAGAAGAATTGCTAGCAGAAGTGGTCCAGGGACAAAGT
AGGACCCCCAGAATAAGTCCCCCCATTAAAGAAGAGGAAACAAAAGGAGATTCTGTAGAAAAAAATCAAGATTACTATGACATGGAATCC
ATGGTCCATGCAGACACAAGATCATTTATTCTGAAGAAGCCAAAGCTGTCTGAGGAAGTAGTAGTGGCACCAAACCAAGAGTCGGGGATG
AAGACTGCAGATTCCCTTCGGGTACTTTCAGGACACCTTATGCAGACACGAGATCTTGTACAACCAGATAAACCTGCAAGTCCCAAGTTT
ATAGTGACGCTGGATGGTGTCCCCAGCCCCCCAGGATACATGTCAGATCAAGAGGAGGACATGTGCTTTGAAGGAATGAAACCCGTAAAC
CAAACTGCAGCCTCAAACAAGGGACTCAGAGGTCTCCTCCACCCACAGCAGTTGCACTTGCTGAGCAGGCAGCTTGAGGACCCAAATGGT
AGCTTTTCTAACGCTGAGATGAGTGAACTGAGTGTGGCACAGAAACCAGAAAAACTTTTGGAGCGCTGCAAGTACTGGCCTGCTTGTAAA
AATGGGGATGAGTGTGCCTACCATCACCCCATCTCACCCTGCAAAGCCTTCCCCAATTGTAAATTTGCTGAAAAATGTTTGTTTGTTCAC
CCAAATTGTAAATATGATGCAAAGTGTACTAAACCAGATTGTCCCTTCACTCATGTGAGTAGAAGAATTCCAGTACTGTCTCCAAAACCA
GCAGTTGCACCACCAGCACCACCTTCCAGTAGTCAGCTCTGCCGTTACTTCCCTGCTTGTAAGAAGATGGAATGTCCCTTCTATCATCCA
AAACATTGTAGGTTTAACACTCAATGTACAAGACCGGACTGCACATTCTACCATCCCACCATTAATGTCCCACCACGACATGCCTTGAAA

>98657_98657_5_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000393514_length(amino acids)=647AA_BP=207
MQGKMIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGKRVSLSV
YLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQ
EGTLTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSV
PAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAEVVQGQSRTPRISPPIKEEETKGDSVEK
NQDYYDMESMVHADTRSFILKKPKLSEEVVVAPNQESGMKTADSLRVLSGHLMQTRDLVQPDKPASPKFIVTLDGVPSPPGYMSDQEEDM
CFEGMKPVNQTAASNKGLRGLLHPQQLHLLSRQLEDPNGSFSNAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPISPCKAFPNCK
FAEKCLFVHPNCKYDAKCTKPDCPFTHVSRRIPVLSPKPAVAPPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTI

--------------------------------------------------------------
>98657_98657_6_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000555755_length(transcript)=2484nt_BP=912nt
GTGGCAGCTCACAGCTATTGTGGTGGGAAAGGGAGGGTGGTTGGTGGATGTCACAGCTTGGGCTTTATCTCCCCCAGCAGTGGGGACTCC
ACAGCCCCTGGGCTACATAACAGCAAGACAGTCCGGAGCTGTAGCAGACCTGATTGAGCCTTTGCAGCAGCTGAGAGCATGGCCTAGGGT
GGGCGGCACCATTGTCCAGCAGCTGAGTTTCCCAGGGACCTTGGAGATAGCCGCAGCCCTCATTTGCAGGGGAAGATGATTCCTGCCAGA
TTTGCCGGGGTGCTGCTTGCTCTGGCCCTCATTTTGCCAGGGACCCTTTGTGCAGAAGGAACTCGCGGCAGGTCATCCACGGCCCGATGC
AGCCTTTTCGGAAGTGACTTCGTCAACACCTTTGATGGGAGCATGTACAGCTTTGCGGGATACTGCAGTTACCTCCTGGCAGGGGGCTGC
CAGAAACGCTCCTTCTCGATTATTGGGGACTTCCAGAATGGCAAGAGAGTGAGCCTCTCCGTGTATCTTGGGGAATTTTTTGACATCCAT
TTGTTTGTCAATGGTACCGTGACACAGGGGGACCAAAGAGTCTCCATGCCCTATGCCTCCAAAGGGCTGTATCTAGAAACTGAGGCTGGG
TACTACAAGCTGTCCGGTGAGGCCTATGGCTTTGTGGCCAGGATCGATGGCAGCGGCAACTTTCAAGTCCTGCTGTCAGACAGATACTTC
AACAAGACCTGCGGGCTGTGTGGCAACTTTAACATCTTTGCTGAAGATGACTTTATGACCCAAGAAGGGACCTTGACCTCGGACCCTTAT
GACTTTGCCAACTCATGGGCTCTGAGCAGTGGAGAACAGTGGTGTGAACGGGCATCTCCTCCCAGCAGCTCATGCAACATCTCCTCTGGG
GAAATGCAGAAGGATGAAAACTTTCGGAAGAGAAAGTTGCCTGTGGTAAGTTCAGTTGTTAAAGTAAAAAAATTCAATCATGATGGAGAA
GAGGAGGAAGAAGATGATGATTACGGGTCTCGAACAGGAAGCATCTCCAGCAGTGTGTCTGTGCCTGCAAAGCCTGAAAGGAGACCTTCT
CTTCCACCTTCTAAACAAGCTAACAAGAATCTGATTTTGAAGGCTATATCTGAAGCTCAAGAATCCGTAACAAAAACAACTAACTACTCT
ACAGTTCCACAGAAACAGACACTTCCAGTTGCTCCCAGAACTCGAACTTCTCAAGAAGAATTGCTAGCAGAAGTGGTCCAGGGACAAAGT
AGGACCCCCAGAATAAGTCCCCCCATTAAAGAAGAGGAAACAAAAGGAGATTCTGTAGAAAAAAATCAAGGAACTCAACAGAGGCAATTA
TTATCCCGACTGCAAATCGACCCAGTAATGGCAGAAACTCTGCAGATGAGTCAAGATTACTATGACATGGAATCCATGGTCCATGCAGAC
ACAAGATCATTTATTCTGAAGAAGCCAAAGCTGTCTGAGGAAGTAGTAGTGGCACCAAACCAAGAGTCGGGGATGAAGACTGCAGATTCC
CTTCGGGTACTTTCAGGACACCTTATGCAGACACGAGATCTTGTACAACCAGATAAACCTGCAAGTCCCAAGTTTATAGTGACGCTGGAT
GGTGTCCCCAGCCCCCCAGGATACATGTCAGATCAAGAGGAGGACATGTGCTTTGAAGGAATGAAACCCGTAAACCAAACTGCAGCCTCA
AACAAGGGACTCAGAGGTCTCCTCCACCCACAGCAGTTGCACTTGCTGAGCAGGCAGCTTGAGGACCCAAATGCTGAGATGAGTGAACTG
AGTGTGGCACAGAAACCAGAAAAACTTTTGGAGCGCTGCAAGTACTGGCCTGCTTGTAAAAATGGGGATGAGTGTGCCTACCATCACCCC
ATCTCACCCTGCAAAGCCTTCCCCAATTGTAAATTTGCTGAAAAATGTTTGTTTGTTCACCCAAATTGTAAATATGATGCAAAGTGTACT
AAACCAGATTGTCCCTTCACTCATGTGAGTAGAAGAATTCCAGTACTGTCTCCAAAACCAGTTGCACCACCAGCACCACCTTCCAGTAGT
CAGCTCTGCCGTTACTTCCCTGCTTGTAAGAAGATGGAATGTCCCTTCTATCATCCAAAACATTGTAGGTTTAACACTCAATGTACAAGA
CCGGACTGCACATTCTACCATCCCACCATTAATGTCCCACCACGACATGCCTTGAAATGGATTCGACCTCAAACCAGCGAATAGCACCCA
GTCCTGCCTGGCAGAAGATCATGCAGTTTGGAAGTTTTCATGTACTGATGAAAGATACTCTACAGAACTTGTCAAATCTTTGAAACTTGG
AATATATTGCTTTCATAATATGAAGTTTTATTGCCTATCTATCTGAAGTGTCTAATTTTTCAAGTTTGTAAGTTTATTATGTGGTTTTAA

>98657_98657_6_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000555755_length(amino acids)=666AA_BP=207
MQGKMIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGKRVSLSV
YLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQ
EGTLTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSV
PAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAEVVQGQSRTPRISPPIKEEETKGDSVEK
NQGTQQRQLLSRLQIDPVMAETLQMSQDYYDMESMVHADTRSFILKKPKLSEEVVVAPNQESGMKTADSLRVLSGHLMQTRDLVQPDKPA
SPKFIVTLDGVPSPPGYMSDQEEDMCFEGMKPVNQTAASNKGLRGLLHPQQLHLLSRQLEDPNAEMSELSVAQKPEKLLERCKYWPACKN
GDECAYHHPISPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHVSRRIPVLSPKPVAPPAPPSSSQLCRYFPACKKMECPFYHPKH

--------------------------------------------------------------
>98657_98657_7_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000556945_length(transcript)=2002nt_BP=912nt
GTGGCAGCTCACAGCTATTGTGGTGGGAAAGGGAGGGTGGTTGGTGGATGTCACAGCTTGGGCTTTATCTCCCCCAGCAGTGGGGACTCC
ACAGCCCCTGGGCTACATAACAGCAAGACAGTCCGGAGCTGTAGCAGACCTGATTGAGCCTTTGCAGCAGCTGAGAGCATGGCCTAGGGT
GGGCGGCACCATTGTCCAGCAGCTGAGTTTCCCAGGGACCTTGGAGATAGCCGCAGCCCTCATTTGCAGGGGAAGATGATTCCTGCCAGA
TTTGCCGGGGTGCTGCTTGCTCTGGCCCTCATTTTGCCAGGGACCCTTTGTGCAGAAGGAACTCGCGGCAGGTCATCCACGGCCCGATGC
AGCCTTTTCGGAAGTGACTTCGTCAACACCTTTGATGGGAGCATGTACAGCTTTGCGGGATACTGCAGTTACCTCCTGGCAGGGGGCTGC
CAGAAACGCTCCTTCTCGATTATTGGGGACTTCCAGAATGGCAAGAGAGTGAGCCTCTCCGTGTATCTTGGGGAATTTTTTGACATCCAT
TTGTTTGTCAATGGTACCGTGACACAGGGGGACCAAAGAGTCTCCATGCCCTATGCCTCCAAAGGGCTGTATCTAGAAACTGAGGCTGGG
TACTACAAGCTGTCCGGTGAGGCCTATGGCTTTGTGGCCAGGATCGATGGCAGCGGCAACTTTCAAGTCCTGCTGTCAGACAGATACTTC
AACAAGACCTGCGGGCTGTGTGGCAACTTTAACATCTTTGCTGAAGATGACTTTATGACCCAAGAAGGGACCTTGACCTCGGACCCTTAT
GACTTTGCCAACTCATGGGCTCTGAGCAGTGGAGAACAGTGGTGTGAACGGGCATCTCCTCCCAGCAGCTCATGCAACATCTCCTCTGGG
GAAATGCAGAAGGATGAAAACTTTCGGAAGAGAAAGTTGCCTGTGGTAAGTTCAGTTGTTAAAGTAAAAAAATTCAATCATGATGGAGAA
GAGGAGGAAGAAGATGATGATTACGGGTCTCGAACAGGAAGCATCTCCAGCAGTGTGTCTGTGCCTGCAAAGCCTGAAAGGAGACCTTCT
CTTCCACCTTCTAAACAAGCTAACAAGAATCTGATTTTGAAGGCTATATCTGAAGCTCAAGAATCCGTAACAAAAACAACTAACTACTCT
ACAGTTCCACAGAAACAGACACTTCCAGTTGCTCCCAGAACTCGAACTTCTCAAGAAGAATTGCTAGCAGAAGTGGTCCAGGGACAAAGT
AGGACCCCCAGAATAAGTCCCCCCATTAAAGAAGAGGAAACAAAAGGAGATTCTGTAGAAAAAAATCAAGGAACTCAACAGAGGCAATTA
TTATCCCGACTGCAAATCGACCCAGTAATGGCAGAAACTCTGCAGATGAGTCAAGCTGAGATGAGTGAACTGAGTGTGGCACAGAAACCA
GAAAAACTTTTGGAGCGCTGCAAGTACTGGCCTGCTTGTAAAAATGGGGATGAGTGTGCCTACCATCACCCCATCTCACCCTGCAAAGCC
TTCCCCAATTGTAAATTTGCTGAAAAATGTTTGTTTGTTCACCCAAATTGTAAATATGATGCAAAGTGTACTAAACCAGATTGTCCCTTC
ACTCATGTGAGTAGAAGAATTCCAGTACTGTCTCCAAAACCAGCAGTTGCACCACCAGCACCACCTTCCAGTAGTCAGCTCTGCCGTTAC
TTCCCTGCTTGTAAGAAGATGGAATGTCCCTTCTATCATCCAAAACATTGTAGGTTTAACACTCAATGTACAAGACCGGACTGCACATTC
TACCATCCCACCATTAATGTCCCACCACGACATGCCTTGAAATGGATTCGACCTCAAACCAGCGAATAGCACCCAGTCCTGCCTGGCAGA
AGATCATGCAGTTTGGAAGTTTTCATGTACTGATGAAAGATACTCTACAGAACTTGTCAAATCTTTGAAACTTGGAATATATTGCTTTCA

>98657_98657_7_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000556945_length(amino acids)=541AA_BP=207
MQGKMIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGKRVSLSV
YLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQ
EGTLTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSV
PAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAEVVQGQSRTPRISPPIKEEETKGDSVEK
NQGTQQRQLLSRLQIDPVMAETLQMSQAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPISPCKAFPNCKFAEKCLFVHPNCKYDA
KCTKPDCPFTHVSRRIPVLSPKPAVAPPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTINVPPRHALKWIRPQTS

--------------------------------------------------------------
>98657_98657_8_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000557607_length(transcript)=2029nt_BP=912nt
GTGGCAGCTCACAGCTATTGTGGTGGGAAAGGGAGGGTGGTTGGTGGATGTCACAGCTTGGGCTTTATCTCCCCCAGCAGTGGGGACTCC
ACAGCCCCTGGGCTACATAACAGCAAGACAGTCCGGAGCTGTAGCAGACCTGATTGAGCCTTTGCAGCAGCTGAGAGCATGGCCTAGGGT
GGGCGGCACCATTGTCCAGCAGCTGAGTTTCCCAGGGACCTTGGAGATAGCCGCAGCCCTCATTTGCAGGGGAAGATGATTCCTGCCAGA
TTTGCCGGGGTGCTGCTTGCTCTGGCCCTCATTTTGCCAGGGACCCTTTGTGCAGAAGGAACTCGCGGCAGGTCATCCACGGCCCGATGC
AGCCTTTTCGGAAGTGACTTCGTCAACACCTTTGATGGGAGCATGTACAGCTTTGCGGGATACTGCAGTTACCTCCTGGCAGGGGGCTGC
CAGAAACGCTCCTTCTCGATTATTGGGGACTTCCAGAATGGCAAGAGAGTGAGCCTCTCCGTGTATCTTGGGGAATTTTTTGACATCCAT
TTGTTTGTCAATGGTACCGTGACACAGGGGGACCAAAGAGTCTCCATGCCCTATGCCTCCAAAGGGCTGTATCTAGAAACTGAGGCTGGG
TACTACAAGCTGTCCGGTGAGGCCTATGGCTTTGTGGCCAGGATCGATGGCAGCGGCAACTTTCAAGTCCTGCTGTCAGACAGATACTTC
AACAAGACCTGCGGGCTGTGTGGCAACTTTAACATCTTTGCTGAAGATGACTTTATGACCCAAGAAGGGACCTTGACCTCGGACCCTTAT
GACTTTGCCAACTCATGGGCTCTGAGCAGTGGAGAACAGTGGTGTGAACGGGCATCTCCTCCCAGCAGCTCATGCAACATCTCCTCTGGG
GAAATGCAGAAGGATGAAAACTTTCGGAAGAGAAAGTTGCCTGTGGTAAGTTCAGTTGTTAAAGTAAAAAAATTCAATCATGATGGAGAA
GAGGAGGAAGAAGATGATGATTACGGGTCTCGAACAGGAAGCATCTCCAGCAGTGTGTCTGTGCCTGCAAAGCCTGAAAGGAGACCTTCT
CTTCCACCTTCTAAACAAGCTAACAAGAATCTGATTTTGAAGGCTATATCTGAAGCTCAAGAATCCGTAACAAAAACAACTAACTACTCT
ACAGTTCCACAGAAACAGACACTTCCAGTTGCTCCCAGAACTCGAACTTCTCAAGAAGAATTGCTAGCAGAAGTGGTCCAGGGACAAAGT
AGGACCCCCAGAATAAGTCCCCCCATTAAAGAAGAGGAAACAAAAGGAGATTCTGTAGAAAAAAATCAAGCTGAGATGAGTGAACTGAGT
GTGGCACAGAAACCAGAAAAACTTTTGGAGCGCTGCAAGTACTGGCCTGCTTGTAAAAATGGGGATGAGTGTGCCTACCATCACCCCATC
TCACCCTGCAAAGCCTTCCCCAATTGTAAATTTGCTGAAAAATGTTTGTTTGTTCACCCAAATTGTAAATATGATGCAAAGTGTACTAAA
CCAGATTGTCCCTTCACTCATGTGAGTAGAAGAATTCCAGTACTGTCTCCAAAACCAGCACCACCTTCCAGTAGTCAGCTCTGCCGTTAC
TTCCCTGCTTGTAAGAAGATGGAATGTCCCTTCTATCATCCAAAACATTGTAGGTTTAACACTCAATGTACAAGACCGGACTGCACATTC
TACCATCCCACCATTAATGTCCCACCACGACATGCCTTGAAATGGATTCGACCTCAAACCAGCGAATAGCACCCAGTCCTGCCTGGCAGA
AGATCATGCAGTTTGGAAGTTTTCATGTACTGATGAAAGATACTCTACAGAACTTGTCAAATCTTTGAAACTTGGAATATATTGCTTTCA
TAATATGAAGTTTTATTGCCTATCTATCTGAAGTGTCTAATTTTTCAAGTTTGTAAGTTTATTATGTGGTTTTAACATTGGGTGTTTTTG

>98657_98657_8_VWF-ZC3H14_VWF_chr12_6204626_ENST00000261405_ZC3H14_chr14_89041037_ENST00000557607_length(amino acids)=511AA_BP=207
MQGKMIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGKRVSLSV
YLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQ
EGTLTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSV
PAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAEVVQGQSRTPRISPPIKEEETKGDSVEK
NQAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPISPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHVSRRIPVLSPKPAP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for VWF-ZC3H14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VWF-ZC3H14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VWF-ZC3H14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource