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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WAC-C10orf76 (FusionGDB2 ID:98668)

Fusion Gene Summary for WAC-C10orf76

check button Fusion gene summary
Fusion gene informationFusion gene name: WAC-C10orf76
Fusion gene ID: 98668
HgeneTgene
Gene symbol

WAC

C10orf76

Gene ID

51322

79591

Gene nameWW domain containing adaptor with coiled-coilarmadillo like helical domain containing 3
SynonymsBM-016|DESSH|PRO1741|Wwp4C10orf76
Cytomap

10p12.1|10p12.1-p11.2

10q24.32

Type of geneprotein-codingprotein-coding
DescriptionWW domain-containing adapter protein with coiled-coilarmadillo-like helical domain-containing protein 3UPF0668 protein C10orf76
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000532233, ENST00000347934, 
ENST00000354911, ENST00000375646, 
ENST00000375664, ENST00000428935, 
ENST00000370033, ENST00000311122, 
ENST00000495001, 
Fusion gene scores* DoF score17 X 16 X 8=21768 X 6 X 5=240
# samples 229
** MAII scorelog2(22/2176*10)=-3.30610312772568
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WAC [Title/Abstract] AND C10orf76 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWAC(28824686)-C10orf76(103699695), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across WAC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C10orf76 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-AG-3887WACchr10

28824686

+C10orf76chr10

103699695

-


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Fusion Gene ORF analysis for WAC-C10orf76

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000532233ENST00000370033WACchr10

28824686

+C10orf76chr10

103699695

-
3UTR-intronENST00000532233ENST00000311122WACchr10

28824686

+C10orf76chr10

103699695

-
3UTR-intronENST00000532233ENST00000495001WACchr10

28824686

+C10orf76chr10

103699695

-
5CDS-intronENST00000347934ENST00000311122WACchr10

28824686

+C10orf76chr10

103699695

-
5CDS-intronENST00000347934ENST00000495001WACchr10

28824686

+C10orf76chr10

103699695

-
5CDS-intronENST00000354911ENST00000311122WACchr10

28824686

+C10orf76chr10

103699695

-
5CDS-intronENST00000354911ENST00000495001WACchr10

28824686

+C10orf76chr10

103699695

-
5CDS-intronENST00000375646ENST00000311122WACchr10

28824686

+C10orf76chr10

103699695

-
5CDS-intronENST00000375646ENST00000495001WACchr10

28824686

+C10orf76chr10

103699695

-
5CDS-intronENST00000375664ENST00000311122WACchr10

28824686

+C10orf76chr10

103699695

-
5CDS-intronENST00000375664ENST00000495001WACchr10

28824686

+C10orf76chr10

103699695

-
5CDS-intronENST00000428935ENST00000311122WACchr10

28824686

+C10orf76chr10

103699695

-
5CDS-intronENST00000428935ENST00000495001WACchr10

28824686

+C10orf76chr10

103699695

-
In-frameENST00000347934ENST00000370033WACchr10

28824686

+C10orf76chr10

103699695

-
In-frameENST00000354911ENST00000370033WACchr10

28824686

+C10orf76chr10

103699695

-
In-frameENST00000375646ENST00000370033WACchr10

28824686

+C10orf76chr10

103699695

-
In-frameENST00000375664ENST00000370033WACchr10

28824686

+C10orf76chr10

103699695

-
In-frameENST00000428935ENST00000370033WACchr10

28824686

+C10orf76chr10

103699695

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375664WACchr1028824686+ENST00000370033C10orf76chr10103699695-30427486091112167
ENST00000375646WACchr1028824686+ENST00000370033C10orf76chr10103699695-2751457318821167
ENST00000347934WACchr1028824686+ENST00000370033C10orf76chr10103699695-2835541171905244
ENST00000354911WACchr1028824686+ENST00000370033C10orf76chr10103699695-272943565799244
ENST00000428935WACchr1028824686+ENST00000370033C10orf76chr10103699695-265335916723235

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375664ENST00000370033WACchr1028824686+C10orf76chr10103699695-0.0088374590.99116254
ENST00000375646ENST00000370033WACchr1028824686+C10orf76chr10103699695-0.0068487220.9931513
ENST00000347934ENST00000370033WACchr1028824686+C10orf76chr10103699695-0.0071450780.9928549
ENST00000354911ENST00000370033WACchr1028824686+C10orf76chr10103699695-0.0096926780.99030733
ENST00000428935ENST00000370033WACchr1028824686+C10orf76chr10103699695-0.0091849240.99081504

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Fusion Genomic Features for WAC-C10orf76


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WAC-C10orf76


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:28824686/chr10:103699695)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWACchr10:28824686chr10:103699695ENST00000347934+313618_64491545.0Coiled coilOntology_term=ECO:0000255
HgeneWACchr10:28824686chr10:103699695ENST00000354911+314618_64491648.0Coiled coilOntology_term=ECO:0000255
HgeneWACchr10:28824686chr10:103699695ENST00000375664+314618_64446603.0Coiled coilOntology_term=ECO:0000255
HgeneWACchr10:28824686chr10:103699695ENST00000428935+310618_64446437.0Coiled coilOntology_term=ECO:0000255
HgeneWACchr10:28824686chr10:103699695ENST00000347934+313129_16291545.0DomainWW
HgeneWACchr10:28824686chr10:103699695ENST00000354911+314129_16291648.0DomainWW
HgeneWACchr10:28824686chr10:103699695ENST00000375664+314129_16246603.0DomainWW
HgeneWACchr10:28824686chr10:103699695ENST00000428935+310129_16246437.0DomainWW
TgeneC10orf76chr10:28824686chr10:103699695ENST000003700332126520_538568690.0TransmembraneHelical


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Fusion Gene Sequence for WAC-C10orf76


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98668_98668_1_WAC-C10orf76_WAC_chr10_28824686_ENST00000347934_C10orf76_chr10_103699695_ENST00000370033_length(transcript)=2835nt_BP=541nt
CGTCGTCTTGCCCCCCTCCCCCCGGTTCGCGGTGCCGCCGTGTAGTTGGCGCCGCTGCCCCGGCTGAGAGTGAGCGTGGTGTCGACGGAG
GGAGATGGCCCGGGAGCGCCGGCGCCAGTAACTGGGAGCTGATGAGAGTCGCCGAGGGCGCGCCGGGCCCAGGTGCCGGGGCTGCCCGCC
GCCCGCCGCCGCCGCCGCCTGCGCGCCCGCCCGCCTTTCGCGGCCGCTCTCCCCCCTCCCCGACACACACTCACAGGCCGGGCATTGATG
GTAATGTATGCGAGGAAACAGCAGAGACTCAGTGATGGCTGTCACGACCGGAGGGGGGACTCGCAGCCTTACCAGGCACTTAAGTATTCA
TCGAAGAGTCACCCCAGTAGCGGTGATCACAGACATGAAAAGATGCGAGACGCCGGAGATCCTTCACCACCAAATAAAATGTTGCGGAGA
TCTGATAGTCCTGAAAACAAATACAGTGACAGCACAGGTCACAGTAAGGCCAAAAATGTGCATACTCACAGAGTTAGAGAGAGGGATGGT
GTCCTGAGGCTTTCTACCAATGCAGGCCAGTGGAAGGAAGCAGCTAGCAAGGTGACCCATGCATTGGTTAATATCAGAGCCATCATCAAC
CACTTTAACCCCAAAATTGAGTCCTACGCTGCTGTGAATCACATATCCCAACTGTCAGAGGAGCAGGTGCTGGAGGTGGTGAGAGCCAAC
TATGACACGCTCACGCTGAAGCTGCAGGATGGCCTGGACCAGTATGAGCGCTACTCAGAGCAGCACAAGGAAGCTGCCTTCTTCAAAGAG
CTGGTTCGATCCATTAGCACCAACGTCCGGAGAAACCTGGCCTTCCACACACTCAGCCAAGAAGTCCTGCTCAAGGAGTTCTCCACTATC
TCCTGAGGCCACGCCTACCTGAGCAGCCTCTGACTGCCCTTACCCATGAGGATCATGGGCTGGAGGGGGAGCGAGGGGAGAGGGGGCTGC
CCCCGAGGTTGGAGAGAAACACAGATACCAAGTTCTCTTGGTGAAGACCGCACTTCAATGGAGCTTGGGCAGCAGGGGCAGGAGGGTCAA
GCCAGGGATAATCTTATTTGGGGAGGAATGGGTGGGCACAGTGGGGAGAGGCCTCCAGGAATGTGGGGACTTCCAGAGTGGGCTCCCTAA
ACAGCCCCTCACATTTCCAATCTTGAGGTTACAAGCTGTAGCTACTGACTAATTTTCGGGAGCTGGTGAGGCAAGCCTCAGGGTAATGCC
AGCACCCTGAAAGTCAGTGGCTCTGCTCGGCTTCTGAAAACAGATCAACTCTCAGATATAGCTGGAGCTACATCCTGCTTCCTTTGGGCC
TGGGGCTGTGCTTGGCTTGAAATCTGTGTCCCCTGCCTGCACTGGCACTTTGTCCAGTCATCGGGACCTTTGGCTCAGATTTAGGGTAAG
ATAGGAATAGGGTACCTTTTTCCTTTTTTTTCTGAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAATGCAGTGGCGTGATCTCGGCTTT
ACTGCAGCCTCCGCTTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGAGCGTGTGCCACGCCCGGCT
AATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTACCCAGGATGGTCTCAATATCCTGAGTTCATGATCCACCCACCTTGGCC
TCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGCCAGTTTTCCTATTTTCTGAATTCAGAATTGACTTCTCTGGGAAAACT
GGAGATGAGAATCTGCCCAGTGCTCTGCTGTCCAGTCACCGCCTTTTGAATTTTAGTTTTGGCACCAGGAGTACCGTTAGCTTTCCCCTT
CTTCTGGCCCATTTGACTCATCAGCACAATAGGGTCACCACCTTAACTTTTAATTTCTAATCTGCTTTACTGTCTTTAGGGTGTGTATGA
AATAAACATTGACAGGCTTTCTGGAGCCCTCAAGGTGCCTACTTTGCTGGTTCCCTTTCCAGCAGCTCCCCCACCTCCCTTAGCCCCCCC
TCCTCTGGCAGCCTCTCCTGCCTCTGCTGAGCTCCCCTCCACGTGTTCCACCCCCTTACCCTGCTGTTGTTTACATCCAACCTGCCTGAG
AATTTCCTCTGGGGAGGAATCTATTCCTGTCATGGTCTAGTGCCTGGGAGGGAGAGAACTTTCTGGGGGTAGGGTGCCCTCCATCTGAAA
CAGGCCAGGTGAGCATCATGCATAAGGCCTCCATTCTGTCCGCTCAGATTCTGGGTGGGGCCACAGGCAAATCTCCTGACTTATGGGGAG
TTGGCTTGTGGTTCCTCCCTTGGATAGCCTCCATGGAACCACTATAGGCTTTCCCAACAGCTGCCTCTGAAATAGCTGCTGCTTCGAGAT
CCTCCCTTTTTAAAGCACTTTCTAAAGCCCTCAGGATGGCGGGAGCAAACAGCACTGGTATATTCTAGGAGTAAGTGCAGGAATTCAGCA
GTGAGAGCATGTCTGGGACCACCTGGACTGCCATCCATTTAACCTCAAATCTCTTTGGGATACTCGCCCTCCCTGGGAACCAGAGTTCTG
GCTCTAACATTGAGCAGCTATGCACTAGTTCCAGAGAAGCCACTAACAGGCTGCCATGTGTAGATGTAGGTTCTTAAGAGATCACAGGCT
GGGTCATCTGATCACTGGATGGATAGCTCAGCCTGGGGCATTTAGTGTTTTCCCTGGTGATAAATCCCCAAGGCAGCTGGATTTGGAGCT

>98668_98668_1_WAC-C10orf76_WAC_chr10_28824686_ENST00000347934_C10orf76_chr10_103699695_ENST00000370033_length(amino acids)=244AA_BP=123
MPAARRRRRLRARPPFAAALPPPRHTLTGRALMVMYARKQQRLSDGCHDRRGDSQPYQALKYSSKSHPSSGDHRHEKMRDAGDPSPPNKM
LRRSDSPENKYSDSTGHSKAKNVHTHRVRERDGVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEVV

--------------------------------------------------------------
>98668_98668_2_WAC-C10orf76_WAC_chr10_28824686_ENST00000354911_C10orf76_chr10_103699695_ENST00000370033_length(transcript)=2729nt_BP=435nt
CGCCGGCGCCAGTAACTGGGAGCTGATGAGAGTCGCCGAGGGCGCGCCGGGCCCAGGTGCCGGGGCTGCCCGCCGCCCGCCGCCGCCGCC
GCCTGCGCGCCCGCCCGCCTTTCGCGGCCGCTCTCCCCCCTCCCCGACACACACTCACAGGCCGGGCATTGATGGTAATGTATGCGAGGA
AACAGCAGAGACTCAGTGATGGCTGTCACGACCGGAGGGGGGACTCGCAGCCTTACCAGGCACTTAAGTATTCATCGAAGAGTCACCCCA
GTAGCGGTGATCACAGACATGAAAAGATGCGAGACGCCGGAGATCCTTCACCACCAAATAAAATGTTGCGGAGATCTGATAGTCCTGAAA
ACAAATACAGTGACAGCACAGGTCACAGTAAGGCCAAAAATGTGCATACTCACAGAGTTAGAGAGAGGGATGGTGTCCTGAGGCTTTCTA
CCAATGCAGGCCAGTGGAAGGAAGCAGCTAGCAAGGTGACCCATGCATTGGTTAATATCAGAGCCATCATCAACCACTTTAACCCCAAAA
TTGAGTCCTACGCTGCTGTGAATCACATATCCCAACTGTCAGAGGAGCAGGTGCTGGAGGTGGTGAGAGCCAACTATGACACGCTCACGC
TGAAGCTGCAGGATGGCCTGGACCAGTATGAGCGCTACTCAGAGCAGCACAAGGAAGCTGCCTTCTTCAAAGAGCTGGTTCGATCCATTA
GCACCAACGTCCGGAGAAACCTGGCCTTCCACACACTCAGCCAAGAAGTCCTGCTCAAGGAGTTCTCCACTATCTCCTGAGGCCACGCCT
ACCTGAGCAGCCTCTGACTGCCCTTACCCATGAGGATCATGGGCTGGAGGGGGAGCGAGGGGAGAGGGGGCTGCCCCCGAGGTTGGAGAG
AAACACAGATACCAAGTTCTCTTGGTGAAGACCGCACTTCAATGGAGCTTGGGCAGCAGGGGCAGGAGGGTCAAGCCAGGGATAATCTTA
TTTGGGGAGGAATGGGTGGGCACAGTGGGGAGAGGCCTCCAGGAATGTGGGGACTTCCAGAGTGGGCTCCCTAAACAGCCCCTCACATTT
CCAATCTTGAGGTTACAAGCTGTAGCTACTGACTAATTTTCGGGAGCTGGTGAGGCAAGCCTCAGGGTAATGCCAGCACCCTGAAAGTCA
GTGGCTCTGCTCGGCTTCTGAAAACAGATCAACTCTCAGATATAGCTGGAGCTACATCCTGCTTCCTTTGGGCCTGGGGCTGTGCTTGGC
TTGAAATCTGTGTCCCCTGCCTGCACTGGCACTTTGTCCAGTCATCGGGACCTTTGGCTCAGATTTAGGGTAAGATAGGAATAGGGTACC
TTTTTCCTTTTTTTTCTGAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAATGCAGTGGCGTGATCTCGGCTTTACTGCAGCCTCCGCTT
CCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGAGCGTGTGCCACGCCCGGCTAATTTTTTGTATTTTT
AGTAGAGATGGGGTTTCACCATGTTACCCAGGATGGTCTCAATATCCTGAGTTCATGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGA
TTACAGGCGTGAGCCACCACACCCAGCCAGTTTTCCTATTTTCTGAATTCAGAATTGACTTCTCTGGGAAAACTGGAGATGAGAATCTGC
CCAGTGCTCTGCTGTCCAGTCACCGCCTTTTGAATTTTAGTTTTGGCACCAGGAGTACCGTTAGCTTTCCCCTTCTTCTGGCCCATTTGA
CTCATCAGCACAATAGGGTCACCACCTTAACTTTTAATTTCTAATCTGCTTTACTGTCTTTAGGGTGTGTATGAAATAAACATTGACAGG
CTTTCTGGAGCCCTCAAGGTGCCTACTTTGCTGGTTCCCTTTCCAGCAGCTCCCCCACCTCCCTTAGCCCCCCCTCCTCTGGCAGCCTCT
CCTGCCTCTGCTGAGCTCCCCTCCACGTGTTCCACCCCCTTACCCTGCTGTTGTTTACATCCAACCTGCCTGAGAATTTCCTCTGGGGAG
GAATCTATTCCTGTCATGGTCTAGTGCCTGGGAGGGAGAGAACTTTCTGGGGGTAGGGTGCCCTCCATCTGAAACAGGCCAGGTGAGCAT
CATGCATAAGGCCTCCATTCTGTCCGCTCAGATTCTGGGTGGGGCCACAGGCAAATCTCCTGACTTATGGGGAGTTGGCTTGTGGTTCCT
CCCTTGGATAGCCTCCATGGAACCACTATAGGCTTTCCCAACAGCTGCCTCTGAAATAGCTGCTGCTTCGAGATCCTCCCTTTTTAAAGC
ACTTTCTAAAGCCCTCAGGATGGCGGGAGCAAACAGCACTGGTATATTCTAGGAGTAAGTGCAGGAATTCAGCAGTGAGAGCATGTCTGG
GACCACCTGGACTGCCATCCATTTAACCTCAAATCTCTTTGGGATACTCGCCCTCCCTGGGAACCAGAGTTCTGGCTCTAACATTGAGCA
GCTATGCACTAGTTCCAGAGAAGCCACTAACAGGCTGCCATGTGTAGATGTAGGTTCTTAAGAGATCACAGGCTGGGTCATCTGATCACT
GGATGGATAGCTCAGCCTGGGGCATTTAGTGTTTTCCCTGGTGATAAATCCCCAAGGCAGCTGGATTTGGAGCTGGTGGCAAGTTGAAAT

>98668_98668_2_WAC-C10orf76_WAC_chr10_28824686_ENST00000354911_C10orf76_chr10_103699695_ENST00000370033_length(amino acids)=244AA_BP=123
MPAARRRRRLRARPPFAAALPPPRHTLTGRALMVMYARKQQRLSDGCHDRRGDSQPYQALKYSSKSHPSSGDHRHEKMRDAGDPSPPNKM
LRRSDSPENKYSDSTGHSKAKNVHTHRVRERDGVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEVV

--------------------------------------------------------------
>98668_98668_3_WAC-C10orf76_WAC_chr10_28824686_ENST00000375646_C10orf76_chr10_103699695_ENST00000370033_length(transcript)=2751nt_BP=457nt
GCGATGGCTTCCCTCGCGCCCCACCGTCCTCTTCCGGAAGGCGGCTCCCTCCCTGCGCAGCCCGGAGCCCCTGAGATCAGCCTCGAGCAG
GCGCCCGAGCGAGACTATCCCTAAACGGGAACGGCGGTGGCCGACTCGCGAGTGAGGAAAAGAAGGAAAGGGCAGACTGGTCGCGAAGAG
AAGATCCAGGCCTCAGAGGAGGAGAAAGGCCGGAGCCAGCCGAGCTGTCACGACCGGAGGGGGGACTCGCAGCCTTACCAGGCACTTAAG
TATTCATCGAAGAGTCACCCCAGTAGCGGTGATCACAGACATGAAAAGATGCGAGACGCCGGAGATCCTTCACCACCAAATAAAATGTTG
CGGAGATCTGATAGTCCTGAAAACAAATACAGTGACAGCACAGGTCACAGTAAGGCCAAAAATGTGCATACTCACAGAGTTAGAGAGAGG
GATGGTGTCCTGAGGCTTTCTACCAATGCAGGCCAGTGGAAGGAAGCAGCTAGCAAGGTGACCCATGCATTGGTTAATATCAGAGCCATC
ATCAACCACTTTAACCCCAAAATTGAGTCCTACGCTGCTGTGAATCACATATCCCAACTGTCAGAGGAGCAGGTGCTGGAGGTGGTGAGA
GCCAACTATGACACGCTCACGCTGAAGCTGCAGGATGGCCTGGACCAGTATGAGCGCTACTCAGAGCAGCACAAGGAAGCTGCCTTCTTC
AAAGAGCTGGTTCGATCCATTAGCACCAACGTCCGGAGAAACCTGGCCTTCCACACACTCAGCCAAGAAGTCCTGCTCAAGGAGTTCTCC
ACTATCTCCTGAGGCCACGCCTACCTGAGCAGCCTCTGACTGCCCTTACCCATGAGGATCATGGGCTGGAGGGGGAGCGAGGGGAGAGGG
GGCTGCCCCCGAGGTTGGAGAGAAACACAGATACCAAGTTCTCTTGGTGAAGACCGCACTTCAATGGAGCTTGGGCAGCAGGGGCAGGAG
GGTCAAGCCAGGGATAATCTTATTTGGGGAGGAATGGGTGGGCACAGTGGGGAGAGGCCTCCAGGAATGTGGGGACTTCCAGAGTGGGCT
CCCTAAACAGCCCCTCACATTTCCAATCTTGAGGTTACAAGCTGTAGCTACTGACTAATTTTCGGGAGCTGGTGAGGCAAGCCTCAGGGT
AATGCCAGCACCCTGAAAGTCAGTGGCTCTGCTCGGCTTCTGAAAACAGATCAACTCTCAGATATAGCTGGAGCTACATCCTGCTTCCTT
TGGGCCTGGGGCTGTGCTTGGCTTGAAATCTGTGTCCCCTGCCTGCACTGGCACTTTGTCCAGTCATCGGGACCTTTGGCTCAGATTTAG
GGTAAGATAGGAATAGGGTACCTTTTTCCTTTTTTTTCTGAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAATGCAGTGGCGTGATCTC
GGCTTTACTGCAGCCTCCGCTTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGAGCGTGTGCCACGC
CCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTACCCAGGATGGTCTCAATATCCTGAGTTCATGATCCACCCACC
TTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGCCAGTTTTCCTATTTTCTGAATTCAGAATTGACTTCTCTGGG
AAAACTGGAGATGAGAATCTGCCCAGTGCTCTGCTGTCCAGTCACCGCCTTTTGAATTTTAGTTTTGGCACCAGGAGTACCGTTAGCTTT
CCCCTTCTTCTGGCCCATTTGACTCATCAGCACAATAGGGTCACCACCTTAACTTTTAATTTCTAATCTGCTTTACTGTCTTTAGGGTGT
GTATGAAATAAACATTGACAGGCTTTCTGGAGCCCTCAAGGTGCCTACTTTGCTGGTTCCCTTTCCAGCAGCTCCCCCACCTCCCTTAGC
CCCCCCTCCTCTGGCAGCCTCTCCTGCCTCTGCTGAGCTCCCCTCCACGTGTTCCACCCCCTTACCCTGCTGTTGTTTACATCCAACCTG
CCTGAGAATTTCCTCTGGGGAGGAATCTATTCCTGTCATGGTCTAGTGCCTGGGAGGGAGAGAACTTTCTGGGGGTAGGGTGCCCTCCAT
CTGAAACAGGCCAGGTGAGCATCATGCATAAGGCCTCCATTCTGTCCGCTCAGATTCTGGGTGGGGCCACAGGCAAATCTCCTGACTTAT
GGGGAGTTGGCTTGTGGTTCCTCCCTTGGATAGCCTCCATGGAACCACTATAGGCTTTCCCAACAGCTGCCTCTGAAATAGCTGCTGCTT
CGAGATCCTCCCTTTTTAAAGCACTTTCTAAAGCCCTCAGGATGGCGGGAGCAAACAGCACTGGTATATTCTAGGAGTAAGTGCAGGAAT
TCAGCAGTGAGAGCATGTCTGGGACCACCTGGACTGCCATCCATTTAACCTCAAATCTCTTTGGGATACTCGCCCTCCCTGGGAACCAGA
GTTCTGGCTCTAACATTGAGCAGCTATGCACTAGTTCCAGAGAAGCCACTAACAGGCTGCCATGTGTAGATGTAGGTTCTTAAGAGATCA
CAGGCTGGGTCATCTGATCACTGGATGGATAGCTCAGCCTGGGGCATTTAGTGTTTTCCCTGGTGATAAATCCCCAAGGCAGCTGGATTT

>98668_98668_3_WAC-C10orf76_WAC_chr10_28824686_ENST00000375646_C10orf76_chr10_103699695_ENST00000370033_length(amino acids)=167AA_BP=46
MRDAGDPSPPNKMLRRSDSPENKYSDSTGHSKAKNVHTHRVRERDGVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNH

--------------------------------------------------------------
>98668_98668_4_WAC-C10orf76_WAC_chr10_28824686_ENST00000375664_C10orf76_chr10_103699695_ENST00000370033_length(transcript)=3042nt_BP=748nt
GGTGGCGCGCGGCGTCCGGTGAGGGGCAGCGGCCCGGGCTCGGTTCCGGCTTCCAGCAGCGGCCCGAAGGCGCCGGAGCACGCTCCCCGC
TCCCCAGAACGCAGCTTCCGCGGCTGCAGCCCAGGCAGCTCTTCGGGAAGCGTCCGCCCGTGGTCTCGCCAGGGGGTTTCCGACCTCCCC
GCCCGACAGCGCAGGGGCGGGGGCCGCGGCCGGAGAGCTCGCCCGAGAGCACCCCCTCCCGCTGCGCCTCTGGGCGCACGCGCAGCCGCT
GCAGCCTCCCTTATTTAGTCCGCGATGGCTTCCCTCGCGCCCCACCGTCCTCTTCCGGAAGGCGGCTCCCTCCCTGCGCAGCCCGGAGCC
CCTGAGATCAGCCTCGAGCAGGCGCCCGAGCGAGACTATCCCTAAACGGGAACGGCGGTGGCCGACTCGCGAGTGAGGAAAAGAAGGAAA
GGGCAGACTGGTCGCGAAGAGAAGATCCAGGCCTCAGAGGAGGAGAAAGGCCGGAGCCAGCCGAGCTGTCACGACCGGAGGGGGGACTCG
CAGCCTTACCAGGCACTTAAGTATTCATCGAAGAGTCACCCCAGTAGCGGTGATCACAGACATGAAAAGATGCGAGACGCCGGAGATCCT
TCACCACCAAATAAAATGTTGCGGAGATCTGATAGTCCTGAAAACAAATACAGTGACAGCACAGGTCACAGTAAGGCCAAAAATGTGCAT
ACTCACAGAGTTAGAGAGAGGGATGGTGTCCTGAGGCTTTCTACCAATGCAGGCCAGTGGAAGGAAGCAGCTAGCAAGGTGACCCATGCA
TTGGTTAATATCAGAGCCATCATCAACCACTTTAACCCCAAAATTGAGTCCTACGCTGCTGTGAATCACATATCCCAACTGTCAGAGGAG
CAGGTGCTGGAGGTGGTGAGAGCCAACTATGACACGCTCACGCTGAAGCTGCAGGATGGCCTGGACCAGTATGAGCGCTACTCAGAGCAG
CACAAGGAAGCTGCCTTCTTCAAAGAGCTGGTTCGATCCATTAGCACCAACGTCCGGAGAAACCTGGCCTTCCACACACTCAGCCAAGAA
GTCCTGCTCAAGGAGTTCTCCACTATCTCCTGAGGCCACGCCTACCTGAGCAGCCTCTGACTGCCCTTACCCATGAGGATCATGGGCTGG
AGGGGGAGCGAGGGGAGAGGGGGCTGCCCCCGAGGTTGGAGAGAAACACAGATACCAAGTTCTCTTGGTGAAGACCGCACTTCAATGGAG
CTTGGGCAGCAGGGGCAGGAGGGTCAAGCCAGGGATAATCTTATTTGGGGAGGAATGGGTGGGCACAGTGGGGAGAGGCCTCCAGGAATG
TGGGGACTTCCAGAGTGGGCTCCCTAAACAGCCCCTCACATTTCCAATCTTGAGGTTACAAGCTGTAGCTACTGACTAATTTTCGGGAGC
TGGTGAGGCAAGCCTCAGGGTAATGCCAGCACCCTGAAAGTCAGTGGCTCTGCTCGGCTTCTGAAAACAGATCAACTCTCAGATATAGCT
GGAGCTACATCCTGCTTCCTTTGGGCCTGGGGCTGTGCTTGGCTTGAAATCTGTGTCCCCTGCCTGCACTGGCACTTTGTCCAGTCATCG
GGACCTTTGGCTCAGATTTAGGGTAAGATAGGAATAGGGTACCTTTTTCCTTTTTTTTCTGAGACGGAGTCTCACTCTGTCGCCCAGGCT
GGAATGCAGTGGCGTGATCTCGGCTTTACTGCAGCCTCCGCTTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGA
CTACAGGAGCGTGTGCCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTACCCAGGATGGTCTCAATATCC
TGAGTTCATGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGCCAGTTTTCCTATTTTCTGAA
TTCAGAATTGACTTCTCTGGGAAAACTGGAGATGAGAATCTGCCCAGTGCTCTGCTGTCCAGTCACCGCCTTTTGAATTTTAGTTTTGGC
ACCAGGAGTACCGTTAGCTTTCCCCTTCTTCTGGCCCATTTGACTCATCAGCACAATAGGGTCACCACCTTAACTTTTAATTTCTAATCT
GCTTTACTGTCTTTAGGGTGTGTATGAAATAAACATTGACAGGCTTTCTGGAGCCCTCAAGGTGCCTACTTTGCTGGTTCCCTTTCCAGC
AGCTCCCCCACCTCCCTTAGCCCCCCCTCCTCTGGCAGCCTCTCCTGCCTCTGCTGAGCTCCCCTCCACGTGTTCCACCCCCTTACCCTG
CTGTTGTTTACATCCAACCTGCCTGAGAATTTCCTCTGGGGAGGAATCTATTCCTGTCATGGTCTAGTGCCTGGGAGGGAGAGAACTTTC
TGGGGGTAGGGTGCCCTCCATCTGAAACAGGCCAGGTGAGCATCATGCATAAGGCCTCCATTCTGTCCGCTCAGATTCTGGGTGGGGCCA
CAGGCAAATCTCCTGACTTATGGGGAGTTGGCTTGTGGTTCCTCCCTTGGATAGCCTCCATGGAACCACTATAGGCTTTCCCAACAGCTG
CCTCTGAAATAGCTGCTGCTTCGAGATCCTCCCTTTTTAAAGCACTTTCTAAAGCCCTCAGGATGGCGGGAGCAAACAGCACTGGTATAT
TCTAGGAGTAAGTGCAGGAATTCAGCAGTGAGAGCATGTCTGGGACCACCTGGACTGCCATCCATTTAACCTCAAATCTCTTTGGGATAC
TCGCCCTCCCTGGGAACCAGAGTTCTGGCTCTAACATTGAGCAGCTATGCACTAGTTCCAGAGAAGCCACTAACAGGCTGCCATGTGTAG
ATGTAGGTTCTTAAGAGATCACAGGCTGGGTCATCTGATCACTGGATGGATAGCTCAGCCTGGGGCATTTAGTGTTTTCCCTGGTGATAA

>98668_98668_4_WAC-C10orf76_WAC_chr10_28824686_ENST00000375664_C10orf76_chr10_103699695_ENST00000370033_length(amino acids)=167AA_BP=46
MRDAGDPSPPNKMLRRSDSPENKYSDSTGHSKAKNVHTHRVRERDGVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNH

--------------------------------------------------------------
>98668_98668_5_WAC-C10orf76_WAC_chr10_28824686_ENST00000428935_C10orf76_chr10_103699695_ENST00000370033_length(transcript)=2653nt_BP=359nt
CCGCCGCCGCCGCCGCCTGCGCGCCCGCCCGCCTTTCGCGGCCGCTCTCCCCCCTCCCCGACACACACTCACAGGCCGGGCATTGATGGT
AATGTATGCGAGGAAACAGCAGAGACTCAGTGATGGCTGTCACGACCGGAGGGGGGACTCGCAGCCTTACCAGGCACTTAAGTATTCATC
GAAGAGTCACCCCAGTAGCGGTGATCACAGACATGAAAAGATGCGAGACGCCGGAGATCCTTCACCACCAAATAAAATGTTGCGGAGATC
TGATAGTCCTGAAAACAAATACAGTGACAGCACAGGTCACAGTAAGGCCAAAAATGTGCATACTCACAGAGTTAGAGAGAGGGATGGTGT
CCTGAGGCTTTCTACCAATGCAGGCCAGTGGAAGGAAGCAGCTAGCAAGGTGACCCATGCATTGGTTAATATCAGAGCCATCATCAACCA
CTTTAACCCCAAAATTGAGTCCTACGCTGCTGTGAATCACATATCCCAACTGTCAGAGGAGCAGGTGCTGGAGGTGGTGAGAGCCAACTA
TGACACGCTCACGCTGAAGCTGCAGGATGGCCTGGACCAGTATGAGCGCTACTCAGAGCAGCACAAGGAAGCTGCCTTCTTCAAAGAGCT
GGTTCGATCCATTAGCACCAACGTCCGGAGAAACCTGGCCTTCCACACACTCAGCCAAGAAGTCCTGCTCAAGGAGTTCTCCACTATCTC
CTGAGGCCACGCCTACCTGAGCAGCCTCTGACTGCCCTTACCCATGAGGATCATGGGCTGGAGGGGGAGCGAGGGGAGAGGGGGCTGCCC
CCGAGGTTGGAGAGAAACACAGATACCAAGTTCTCTTGGTGAAGACCGCACTTCAATGGAGCTTGGGCAGCAGGGGCAGGAGGGTCAAGC
CAGGGATAATCTTATTTGGGGAGGAATGGGTGGGCACAGTGGGGAGAGGCCTCCAGGAATGTGGGGACTTCCAGAGTGGGCTCCCTAAAC
AGCCCCTCACATTTCCAATCTTGAGGTTACAAGCTGTAGCTACTGACTAATTTTCGGGAGCTGGTGAGGCAAGCCTCAGGGTAATGCCAG
CACCCTGAAAGTCAGTGGCTCTGCTCGGCTTCTGAAAACAGATCAACTCTCAGATATAGCTGGAGCTACATCCTGCTTCCTTTGGGCCTG
GGGCTGTGCTTGGCTTGAAATCTGTGTCCCCTGCCTGCACTGGCACTTTGTCCAGTCATCGGGACCTTTGGCTCAGATTTAGGGTAAGAT
AGGAATAGGGTACCTTTTTCCTTTTTTTTCTGAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAATGCAGTGGCGTGATCTCGGCTTTAC
TGCAGCCTCCGCTTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGAGCGTGTGCCACGCCCGGCTAA
TTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTACCCAGGATGGTCTCAATATCCTGAGTTCATGATCCACCCACCTTGGCCTC
CCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGCCAGTTTTCCTATTTTCTGAATTCAGAATTGACTTCTCTGGGAAAACTGG
AGATGAGAATCTGCCCAGTGCTCTGCTGTCCAGTCACCGCCTTTTGAATTTTAGTTTTGGCACCAGGAGTACCGTTAGCTTTCCCCTTCT
TCTGGCCCATTTGACTCATCAGCACAATAGGGTCACCACCTTAACTTTTAATTTCTAATCTGCTTTACTGTCTTTAGGGTGTGTATGAAA
TAAACATTGACAGGCTTTCTGGAGCCCTCAAGGTGCCTACTTTGCTGGTTCCCTTTCCAGCAGCTCCCCCACCTCCCTTAGCCCCCCCTC
CTCTGGCAGCCTCTCCTGCCTCTGCTGAGCTCCCCTCCACGTGTTCCACCCCCTTACCCTGCTGTTGTTTACATCCAACCTGCCTGAGAA
TTTCCTCTGGGGAGGAATCTATTCCTGTCATGGTCTAGTGCCTGGGAGGGAGAGAACTTTCTGGGGGTAGGGTGCCCTCCATCTGAAACA
GGCCAGGTGAGCATCATGCATAAGGCCTCCATTCTGTCCGCTCAGATTCTGGGTGGGGCCACAGGCAAATCTCCTGACTTATGGGGAGTT
GGCTTGTGGTTCCTCCCTTGGATAGCCTCCATGGAACCACTATAGGCTTTCCCAACAGCTGCCTCTGAAATAGCTGCTGCTTCGAGATCC
TCCCTTTTTAAAGCACTTTCTAAAGCCCTCAGGATGGCGGGAGCAAACAGCACTGGTATATTCTAGGAGTAAGTGCAGGAATTCAGCAGT
GAGAGCATGTCTGGGACCACCTGGACTGCCATCCATTTAACCTCAAATCTCTTTGGGATACTCGCCCTCCCTGGGAACCAGAGTTCTGGC
TCTAACATTGAGCAGCTATGCACTAGTTCCAGAGAAGCCACTAACAGGCTGCCATGTGTAGATGTAGGTTCTTAAGAGATCACAGGCTGG
GTCATCTGATCACTGGATGGATAGCTCAGCCTGGGGCATTTAGTGTTTTCCCTGGTGATAAATCCCCAAGGCAGCTGGATTTGGAGCTGG

>98668_98668_5_WAC-C10orf76_WAC_chr10_28824686_ENST00000428935_C10orf76_chr10_103699695_ENST00000370033_length(amino acids)=235AA_BP=114
MRARPPFAAALPPPRHTLTGRALMVMYARKQQRLSDGCHDRRGDSQPYQALKYSSKSHPSSGDHRHEKMRDAGDPSPPNKMLRRSDSPEN
KYSDSTGHSKAKNVHTHRVRERDGVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEVVRANYDTLTL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WAC-C10orf76


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WAC-C10orf76


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WAC-C10orf76


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource