FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:BMP5-COL21A1 (FusionGDB2 ID:9870)

Fusion Gene Summary for BMP5-COL21A1

check button Fusion gene summary
Fusion gene informationFusion gene name: BMP5-COL21A1
Fusion gene ID: 9870
HgeneTgene
Gene symbol

BMP5

COL21A1

Gene ID

653

81578

Gene namebone morphogenetic protein 5collagen type XXI alpha 1 chain
Synonyms-COLA1L|FP633
Cytomap

6p12.1

6p12.1|6p12.3-p11.2

Type of geneprotein-codingprotein-coding
Descriptionbone morphogenetic protein 5collagen alpha-1(XXI) chainalpha 1 chain-like collagencollagen, type XXI, alpha 1
Modification date2020031320200320
UniProtAcc.

Q96P44

Ensembl transtripts involved in fusion geneENST00000370830, ENST00000446683, 
ENST00000370808, ENST00000467045, 
ENST00000244728, ENST00000370819, 
ENST00000535941, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 7 X 6=336
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BMP5 [Title/Abstract] AND COL21A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBMP5(55739174)-COL21A1(55966323), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBMP5

GO:0003323

type B pancreatic cell development

11865031

HgeneBMP5

GO:0008284

positive regulation of cell proliferation

15516325

HgeneBMP5

GO:0008285

negative regulation of cell proliferation

19584291

HgeneBMP5

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

11580864

HgeneBMP5

GO:0010894

negative regulation of steroid biosynthetic process

19584291

HgeneBMP5

GO:0032348

negative regulation of aldosterone biosynthetic process

19584291

HgeneBMP5

GO:0043569

negative regulation of insulin-like growth factor receptor signaling pathway

19584291

HgeneBMP5

GO:0045944

positive regulation of transcription by RNA polymerase II

15516325

HgeneBMP5

GO:0050679

positive regulation of epithelial cell proliferation

11865031

HgeneBMP5

GO:1900006

positive regulation of dendrite development

11580864

HgeneBMP5

GO:2000065

negative regulation of cortisol biosynthetic process

19584291


check buttonFusion gene breakpoints across BMP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COL21A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-49-4488-01ABMP5chr6

55739174

-COL21A1chr6

55966323

-


Top

Fusion Gene ORF analysis for BMP5-COL21A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000370830ENST00000370808BMP5chr6

55739174

-COL21A1chr6

55966323

-
5CDS-intronENST00000370830ENST00000467045BMP5chr6

55739174

-COL21A1chr6

55966323

-
5CDS-intronENST00000446683ENST00000370808BMP5chr6

55739174

-COL21A1chr6

55966323

-
5CDS-intronENST00000446683ENST00000467045BMP5chr6

55739174

-COL21A1chr6

55966323

-
In-frameENST00000370830ENST00000244728BMP5chr6

55739174

-COL21A1chr6

55966323

-
In-frameENST00000370830ENST00000370819BMP5chr6

55739174

-COL21A1chr6

55966323

-
In-frameENST00000370830ENST00000535941BMP5chr6

55739174

-COL21A1chr6

55966323

-
In-frameENST00000446683ENST00000244728BMP5chr6

55739174

-COL21A1chr6

55966323

-
In-frameENST00000446683ENST00000370819BMP5chr6

55739174

-COL21A1chr6

55966323

-
In-frameENST00000446683ENST00000535941BMP5chr6

55739174

-COL21A1chr6

55966323

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370830BMP5chr655739174-ENST00000244728COL21A1chr655966323-3372118912762304342
ENST00000370830BMP5chr655739174-ENST00000370819COL21A1chr655966323-3372118912762304342
ENST00000370830BMP5chr655739174-ENST00000535941COL21A1chr655966323-3371118912762304342
ENST00000446683BMP5chr655739174-ENST00000244728COL21A1chr655966323-26875045911619342
ENST00000446683BMP5chr655739174-ENST00000370819COL21A1chr655966323-26875045911619342
ENST00000446683BMP5chr655739174-ENST00000535941COL21A1chr655966323-26865045911619342

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370830ENST00000244728BMP5chr655739174-COL21A1chr655966323-0.0016595650.99834037
ENST00000370830ENST00000370819BMP5chr655739174-COL21A1chr655966323-0.0016595650.99834037
ENST00000370830ENST00000535941BMP5chr655739174-COL21A1chr655966323-0.0016592170.9983407
ENST00000446683ENST00000244728BMP5chr655739174-COL21A1chr655966323-0.0016381530.9983619
ENST00000446683ENST00000370819BMP5chr655739174-COL21A1chr655966323-0.0016381530.9983619
ENST00000446683ENST00000535941BMP5chr655739174-COL21A1chr655966323-0.0016297970.99837023

Top

Fusion Genomic Features for BMP5-COL21A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for BMP5-COL21A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:55739174/chr6:55966323)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COL21A1

Q96P44

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOL21A1chr6:55739174chr6:55966323ENST000002447281530681_733586958.0DomainNote=Collagen-like 4
TgeneCOL21A1chr6:55739174chr6:55966323ENST000002447281530734_787586958.0DomainNote=Collagen-like 5
TgeneCOL21A1chr6:55739174chr6:55966323ENST000002447281530825_882586958.0DomainNote=Collagen-like 6
TgeneCOL21A1chr6:55739174chr6:55966323ENST000002447281530884_934586958.0DomainNote=Collagen-like 7
TgeneCOL21A1chr6:55739174chr6:55966323ENST00000370808014230_4120324.0DomainNote=Laminin G-like
TgeneCOL21A1chr6:55739174chr6:55966323ENST0000037080801437_2110324.0DomainVWFA
TgeneCOL21A1chr6:55739174chr6:55966323ENST00000370808014448_5000324.0DomainNote=Collagen-like 1
TgeneCOL21A1chr6:55739174chr6:55966323ENST00000370808014501_5420324.0DomainNote=Collagen-like 2
TgeneCOL21A1chr6:55739174chr6:55966323ENST00000370808014543_5940324.0DomainNote=Collagen-like 3
TgeneCOL21A1chr6:55739174chr6:55966323ENST00000370808014681_7330324.0DomainNote=Collagen-like 4
TgeneCOL21A1chr6:55739174chr6:55966323ENST00000370808014734_7870324.0DomainNote=Collagen-like 5
TgeneCOL21A1chr6:55739174chr6:55966323ENST00000370808014825_8820324.0DomainNote=Collagen-like 6
TgeneCOL21A1chr6:55739174chr6:55966323ENST00000370808014884_9340324.0DomainNote=Collagen-like 7
TgeneCOL21A1chr6:55739174chr6:55966323ENST000003708191429681_733583955.0DomainNote=Collagen-like 4
TgeneCOL21A1chr6:55739174chr6:55966323ENST000003708191429734_787583955.0DomainNote=Collagen-like 5
TgeneCOL21A1chr6:55739174chr6:55966323ENST000003708191429825_882583955.0DomainNote=Collagen-like 6
TgeneCOL21A1chr6:55739174chr6:55966323ENST000003708191429884_934583955.0DomainNote=Collagen-like 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOL21A1chr6:55739174chr6:55966323ENST000002447281530230_412586958.0DomainNote=Laminin G-like
TgeneCOL21A1chr6:55739174chr6:55966323ENST00000244728153037_211586958.0DomainVWFA
TgeneCOL21A1chr6:55739174chr6:55966323ENST000002447281530448_500586958.0DomainNote=Collagen-like 1
TgeneCOL21A1chr6:55739174chr6:55966323ENST000002447281530501_542586958.0DomainNote=Collagen-like 2
TgeneCOL21A1chr6:55739174chr6:55966323ENST000002447281530543_594586958.0DomainNote=Collagen-like 3
TgeneCOL21A1chr6:55739174chr6:55966323ENST000003708191429230_412583955.0DomainNote=Laminin G-like
TgeneCOL21A1chr6:55739174chr6:55966323ENST00000370819142937_211583955.0DomainVWFA
TgeneCOL21A1chr6:55739174chr6:55966323ENST000003708191429448_500583955.0DomainNote=Collagen-like 1
TgeneCOL21A1chr6:55739174chr6:55966323ENST000003708191429501_542583955.0DomainNote=Collagen-like 2
TgeneCOL21A1chr6:55739174chr6:55966323ENST000003708191429543_594583955.0DomainNote=Collagen-like 3


Top

Fusion Gene Sequence for BMP5-COL21A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9870_9870_1_BMP5-COL21A1_BMP5_chr6_55739174_ENST00000370830_COL21A1_chr6_55966323_ENST00000244728_length(transcript)=3372nt_BP=1189nt
CTGGTATATTTGTGCCTGCTGGAGGTGGAATTAACAGTAAGAAGGAGAAAGGGATTGAATGGACTTACAGGAAGGATTTCAAGTAAATTC
AGGGAAACACATTTACTTGAATAGTACAACCTAGAGTATTATTTTACACTAAGACGACACAAAAGATGTTAAAGTTATCACCAAGCTGCC
GGACAGATATATATTCCAACACCAAGGTGCAGATCAGCATAGATCTGTGATTCAGAAATCAGGATTTGTTTTGGAAAGAGCTCAAGGGTT
GAGAAGAACTCAAAAGCAAGTGAAGATTACTTTGGGAACTACAGTTTATCAGAAGATCAACTTTTGCTAATTCAAATACCAAAGGCCTGA
TTATCATAAATTCATATAGGAATGCATAGGTCATCTGATCAAATAATATTAGCCGTCTTCTGCTACATCAATGCAGCAAAAACTCTTAAC
AACTGTGGATAATTGGAAATCTGAGTTTCAGCTTTCTTAGAAATAACTACTCTTGACATATTCCAAAATATTTAAAATAGGACAGGAAAA
TCGGTGAGGATGTTGTGCTCAGAAATGTCACTGTCATGAAAAATAGGTAAATTTGTTTTTTCAGCTACTGGGAAACTGTACCTCCTAGAA
CCTTAGGTTTTTTTTTTTTTTAAGAGGACAAGAAGGACTAAAAATATCAACTTTTGCTTTTGGACAAAAATGCATCTGACTGTATTTTTA
CTTAAGGGTATTGTGGGTTTCCTCTGGAGCTGCTGGGTTCTAGTGGGTTATGCAAAAGGAGGTTTGGGAGACAATCATGTTCACTCCAGT
TTTATTTATAGAAGACTACGGAACCACGAAAGACGGGAAATACAAAGGGAAATTCTCTCTATCTTGGGTTTGCCTCACAGACCCAGACCA
TTTTCACCTGGAAAACAAGCGTCCTCTGCACCTCTCTTTATGCTGGATCTCTACAATGCCATGACCAATGAAGAAAATCCTGAAGAGTCG
GAGTACTCAGTAAGGGCATCCTTGGCAGAAGAGACCAGAGGGGCAAGAAAGGGATACCCAGCCTCTCCCAATGGGTATCCTCGTCGCATA
CAGTTATCTCGGACGACTCCTCTGACCACCCAGAGTCCTCCTCTAGCCAGCCTCCATGATACCAACTTTCTGAATGATGCTGACATGGTC
ATGAGCTTTGTCAACTTAGGGAGAAGCAGGATCCCCTGGTGCTCCGGGGCAGGATGGAACACGGGGAGAGCCTGGAATCCCAGGATTTCC
TGGAAACCGAGGATTAATGGGCCAAAAGGGAGAAATTGGGCCTCCAGGACAGCAAGGAAAAAAAGGAGCCCCAGGGATGCCTGGTTTAAT
GGGAAGCAATGGCTCACCAGGCCAGCCTGGAACACCGGGATCTAAGGGAAGCAAAGGTGAACCTGGAATTCAAGGGATGCCTGGGGCTTC
TGGGCTCAAGGGAGAACCAGGAGCAACGGGTTCCCCAGGAGAACCAGGATACATGGGTTTACCCGGGATTCAAGGAAAAAAGGGGGACAA
AGGAAATCAAGGTGAAAAAGGTATTCAGGGTCAAAAGGGAGAAAATGGAAGACAGGGAATTCCAGGGCAACAGGGAATTCAAGGCCATCA
TGGTGCAAAAGGAGAGAGAGGTGAAAAGGGAGAACCTGGTGTCCGAGGTGCCATTGGATCAAAAGGAGAATCTGGGGTGGATGGCTTGAT
GGGGCCCGCAGGTCCTAAGGGGCAACCTGGGGATCCAGGTCCTCAGGGACCCCCAGGTTTGGATGGGAAGCCCGGAAGAGAGTTTTCAGA
ACAATTTATTCGACAAGTTTGCACAGATGTAATAAGAGCCCAGCTACCAGTCTTACTTCAGAGTGGAAGAATTAGAAATTGTGATCATTG
CCTGTCCCAACATGGCTCCCCGGGTATTCCTGGGCCACCTGGTCCGATAGGCCCAGAGGGTCCCAGAGGATTACCTGGTTTGCCAGGAAG
AGATGGTGTTCCTGGATTAGTGGGTGTCCCTGGACGTCCAGGTGTCAGAGGATTAAAAGGCCTACCAGGAAGAAATGGGGAAAAAGGGAG
CCAAGGGTTTGGGTATCCTGGAGAACAAGGTCCTCCTGGTCCCCCAGGTCCAGAGGGCCCTCCTGGAATAAGCAAAGAAGGTCCTCCAGG
AGACCCAGGTCTCCCTGGCAAAGATGGAGACCATGGAAAACCTGGAATCCAAGGGCAACCAGGCCCCCCAGGCATCTGCGACCCATCACT
ATGTTTTAGTGTAATTGCCAGAAGAGATCCGTTCAGAAAAGGACCAAACTATTAGTGTCTGATGCCTCATTCAGCAGCCTAGGCATGGTG
CTTTTTCTGTGGTCTTTTGCATCTCAGGAAGATAACCAACAGTAATCCCTTGAAAAGAAACTTAAGTACCTCGGTGTTTTTATTTTTTTT
TTCTTATGGAAAAAAATATAAAAGATCACATATACTGATTTTAAAGGCTCCTCAGTCATTTGGAGCCCTTGGATTAGCAGCATTAATTAA
ATCTCAAGGGTTTCTTGTAAAGTCCATTTATGTTAATCAAAGTTGAATATAAAAATCCACCATTGCCTGTTAGCCAGTCAGTTTTAGTCA
CTGTGAAATATTTCACATTCAGCCTCCATGCAGTAGAGATTTGAGTTTAATTTCATGTCCATGTGACTTTCATGTTTCCTATCTCATAGC
TCATGCTACTACATAAGCCAAAACATGTATCTCATCATTGGAAGTAAGATCAGGGCTGATATTCACCTGGGATAGACAGTATTGGTGAAC
TACTCATTTACTACAGTGTCTCAGCCTTGATAAGGGGCAGTGGATTGCCTGTTGTTCGGTGTTGTGAATAGCACCTCTGAATAAGATTAG
AGTGTTTCTTAATTCATTTCAAACTCTAAAATTAGATTAATGGTGGTGCTAAGAAAGAGTATTAATTACTTTGGGAATGGTCAAAATTAA
CATTAAAAACATTTTAGACAAAAAGTTTCATTGTACATTCAAAGAAAATGTAAGTTTGGAAGTACTAAAAGACTATTTTATACTTGTTGA
TTAATCGGAATGTTTGTTGTATGCCTTCATTTTCCATTTCACTTATATGTGTATGTCCATATATGTTAATTTTCATTGTAGCAAAGCTAA
TGGAAATAAAGCTAATGCTCTAGTTGAAAGAAAAGGAAAACTCCTGAAATCCTAGAATGTCTTGTTATTTTTAGCTGACTGTAAAATATT
ATGAACAGTCTTTGTGTATTGTGCTTAATGCTTTTGTAAGAAACAGAATTTGAAATATTTCATCCTTGTCATGCTCAAAATTTTGTTACA

>9870_9870_1_BMP5-COL21A1_BMP5_chr6_55739174_ENST00000370830_COL21A1_chr6_55966323_ENST00000244728_length(amino acids)=342AA_BP=
MGQKGEIGPPGQQGKKGAPGMPGLMGSNGSPGQPGTPGSKGSKGEPGIQGMPGASGLKGEPGATGSPGEPGYMGLPGIQGKKGDKGNQGE
KGIQGQKGENGRQGIPGQQGIQGHHGAKGERGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQ
VCTDVIRAQLPVLLQSGRIRNCDHCLSQHGSPGIPGPPGPIGPEGPRGLPGLPGRDGVPGLVGVPGRPGVRGLKGLPGRNGEKGSQGFGY

--------------------------------------------------------------
>9870_9870_2_BMP5-COL21A1_BMP5_chr6_55739174_ENST00000370830_COL21A1_chr6_55966323_ENST00000370819_length(transcript)=3372nt_BP=1189nt
CTGGTATATTTGTGCCTGCTGGAGGTGGAATTAACAGTAAGAAGGAGAAAGGGATTGAATGGACTTACAGGAAGGATTTCAAGTAAATTC
AGGGAAACACATTTACTTGAATAGTACAACCTAGAGTATTATTTTACACTAAGACGACACAAAAGATGTTAAAGTTATCACCAAGCTGCC
GGACAGATATATATTCCAACACCAAGGTGCAGATCAGCATAGATCTGTGATTCAGAAATCAGGATTTGTTTTGGAAAGAGCTCAAGGGTT
GAGAAGAACTCAAAAGCAAGTGAAGATTACTTTGGGAACTACAGTTTATCAGAAGATCAACTTTTGCTAATTCAAATACCAAAGGCCTGA
TTATCATAAATTCATATAGGAATGCATAGGTCATCTGATCAAATAATATTAGCCGTCTTCTGCTACATCAATGCAGCAAAAACTCTTAAC
AACTGTGGATAATTGGAAATCTGAGTTTCAGCTTTCTTAGAAATAACTACTCTTGACATATTCCAAAATATTTAAAATAGGACAGGAAAA
TCGGTGAGGATGTTGTGCTCAGAAATGTCACTGTCATGAAAAATAGGTAAATTTGTTTTTTCAGCTACTGGGAAACTGTACCTCCTAGAA
CCTTAGGTTTTTTTTTTTTTTAAGAGGACAAGAAGGACTAAAAATATCAACTTTTGCTTTTGGACAAAAATGCATCTGACTGTATTTTTA
CTTAAGGGTATTGTGGGTTTCCTCTGGAGCTGCTGGGTTCTAGTGGGTTATGCAAAAGGAGGTTTGGGAGACAATCATGTTCACTCCAGT
TTTATTTATAGAAGACTACGGAACCACGAAAGACGGGAAATACAAAGGGAAATTCTCTCTATCTTGGGTTTGCCTCACAGACCCAGACCA
TTTTCACCTGGAAAACAAGCGTCCTCTGCACCTCTCTTTATGCTGGATCTCTACAATGCCATGACCAATGAAGAAAATCCTGAAGAGTCG
GAGTACTCAGTAAGGGCATCCTTGGCAGAAGAGACCAGAGGGGCAAGAAAGGGATACCCAGCCTCTCCCAATGGGTATCCTCGTCGCATA
CAGTTATCTCGGACGACTCCTCTGACCACCCAGAGTCCTCCTCTAGCCAGCCTCCATGATACCAACTTTCTGAATGATGCTGACATGGTC
ATGAGCTTTGTCAACTTAGGGAGAAGCAGGATCCCCTGGTGCTCCGGGGCAGGATGGAACACGGGGAGAGCCTGGAATCCCAGGATTTCC
TGGAAACCGAGGATTAATGGGCCAAAAGGGAGAAATTGGGCCTCCAGGACAGCAAGGAAAAAAAGGAGCCCCAGGGATGCCTGGTTTAAT
GGGAAGCAATGGCTCACCAGGCCAGCCTGGAACACCGGGATCTAAGGGAAGCAAAGGTGAACCTGGAATTCAAGGGATGCCTGGGGCTTC
TGGGCTCAAGGGAGAACCAGGAGCAACGGGTTCCCCAGGAGAACCAGGATACATGGGTTTACCCGGGATTCAAGGAAAAAAGGGGGACAA
AGGAAATCAAGGTGAAAAAGGTATTCAGGGTCAAAAGGGAGAAAATGGAAGACAGGGAATTCCAGGGCAACAGGGAATTCAAGGCCATCA
TGGTGCAAAAGGAGAGAGAGGTGAAAAGGGAGAACCTGGTGTCCGAGGTGCCATTGGATCAAAAGGAGAATCTGGGGTGGATGGCTTGAT
GGGGCCCGCAGGTCCTAAGGGGCAACCTGGGGATCCAGGTCCTCAGGGACCCCCAGGTTTGGATGGGAAGCCCGGAAGAGAGTTTTCAGA
ACAATTTATTCGACAAGTTTGCACAGATGTAATAAGAGCCCAGCTACCAGTCTTACTTCAGAGTGGAAGAATTAGAAATTGTGATCATTG
CCTGTCCCAACATGGCTCCCCGGGTATTCCTGGGCCACCTGGTCCGATAGGCCCAGAGGGTCCCAGAGGATTACCTGGTTTGCCAGGAAG
AGATGGTGTTCCTGGATTAGTGGGTGTCCCTGGACGTCCAGGTGTCAGAGGATTAAAAGGCCTACCAGGAAGAAATGGGGAAAAAGGGAG
CCAAGGGTTTGGGTATCCTGGAGAACAAGGTCCTCCTGGTCCCCCAGGTCCAGAGGGCCCTCCTGGAATAAGCAAAGAAGGTCCTCCAGG
AGACCCAGGTCTCCCTGGCAAAGATGGAGACCATGGAAAACCTGGAATCCAAGGGCAACCAGGCCCCCCAGGCATCTGCGACCCATCACT
ATGTTTTAGTGTAATTGCCAGAAGAGATCCGTTCAGAAAAGGACCAAACTATTAGTGTCTGATGCCTCATTCAGCAGCCTAGGCATGGTG
CTTTTTCTGTGGTCTTTTGCATCTCAGGAAGATAACCAACAGTAATCCCTTGAAAAGAAACTTAAGTACCTCGGTGTTTTTATTTTTTTT
TTCTTATGGAAAAAAATATAAAAGATCACATATACTGATTTTAAAGGCTCCTCAGTCATTTGGAGCCCTTGGATTAGCAGCATTAATTAA
ATCTCAAGGGTTTCTTGTAAAGTCCATTTATGTTAATCAAAGTTGAATATAAAAATCCACCATTGCCTGTTAGCCAGTCAGTTTTAGTCA
CTGTGAAATATTTCACATTCAGCCTCCATGCAGTAGAGATTTGAGTTTAATTTCATGTCCATGTGACTTTCATGTTTCCTATCTCATAGC
TCATGCTACTACATAAGCCAAAACATGTATCTCATCATTGGAAGTAAGATCAGGGCTGATATTCACCTGGGATAGACAGTATTGGTGAAC
TACTCATTTACTACAGTGTCTCAGCCTTGATAAGGGGCAGTGGATTGCCTGTTGTTCGGTGTTGTGAATAGCACCTCTGAATAAGATTAG
AGTGTTTCTTAATTCATTTCAAACTCTAAAATTAGATTAATGGTGGTGCTAAGAAAGAGTATTAATTACTTTGGGAATGGTCAAAATTAA
CATTAAAAACATTTTAGACAAAAAGTTTCATTGTACATTCAAAGAAAATGTAAGTTTGGAAGTACTAAAAGACTATTTTATACTTGTTGA
TTAATCGGAATGTTTGTTGTATGCCTTCATTTTCCATTTCACTTATATGTGTATGTCCATATATGTTAATTTTCATTGTAGCAAAGCTAA
TGGAAATAAAGCTAATGCTCTAGTTGAAAGAAAAGGAAAACTCCTGAAATCCTAGAATGTCTTGTTATTTTTAGCTGACTGTAAAATATT
ATGAACAGTCTTTGTGTATTGTGCTTAATGCTTTTGTAAGAAACAGAATTTGAAATATTTCATCCTTGTCATGCTCAAAATTTTGTTACA

>9870_9870_2_BMP5-COL21A1_BMP5_chr6_55739174_ENST00000370830_COL21A1_chr6_55966323_ENST00000370819_length(amino acids)=342AA_BP=
MGQKGEIGPPGQQGKKGAPGMPGLMGSNGSPGQPGTPGSKGSKGEPGIQGMPGASGLKGEPGATGSPGEPGYMGLPGIQGKKGDKGNQGE
KGIQGQKGENGRQGIPGQQGIQGHHGAKGERGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQ
VCTDVIRAQLPVLLQSGRIRNCDHCLSQHGSPGIPGPPGPIGPEGPRGLPGLPGRDGVPGLVGVPGRPGVRGLKGLPGRNGEKGSQGFGY

--------------------------------------------------------------
>9870_9870_3_BMP5-COL21A1_BMP5_chr6_55739174_ENST00000370830_COL21A1_chr6_55966323_ENST00000535941_length(transcript)=3371nt_BP=1189nt
CTGGTATATTTGTGCCTGCTGGAGGTGGAATTAACAGTAAGAAGGAGAAAGGGATTGAATGGACTTACAGGAAGGATTTCAAGTAAATTC
AGGGAAACACATTTACTTGAATAGTACAACCTAGAGTATTATTTTACACTAAGACGACACAAAAGATGTTAAAGTTATCACCAAGCTGCC
GGACAGATATATATTCCAACACCAAGGTGCAGATCAGCATAGATCTGTGATTCAGAAATCAGGATTTGTTTTGGAAAGAGCTCAAGGGTT
GAGAAGAACTCAAAAGCAAGTGAAGATTACTTTGGGAACTACAGTTTATCAGAAGATCAACTTTTGCTAATTCAAATACCAAAGGCCTGA
TTATCATAAATTCATATAGGAATGCATAGGTCATCTGATCAAATAATATTAGCCGTCTTCTGCTACATCAATGCAGCAAAAACTCTTAAC
AACTGTGGATAATTGGAAATCTGAGTTTCAGCTTTCTTAGAAATAACTACTCTTGACATATTCCAAAATATTTAAAATAGGACAGGAAAA
TCGGTGAGGATGTTGTGCTCAGAAATGTCACTGTCATGAAAAATAGGTAAATTTGTTTTTTCAGCTACTGGGAAACTGTACCTCCTAGAA
CCTTAGGTTTTTTTTTTTTTTAAGAGGACAAGAAGGACTAAAAATATCAACTTTTGCTTTTGGACAAAAATGCATCTGACTGTATTTTTA
CTTAAGGGTATTGTGGGTTTCCTCTGGAGCTGCTGGGTTCTAGTGGGTTATGCAAAAGGAGGTTTGGGAGACAATCATGTTCACTCCAGT
TTTATTTATAGAAGACTACGGAACCACGAAAGACGGGAAATACAAAGGGAAATTCTCTCTATCTTGGGTTTGCCTCACAGACCCAGACCA
TTTTCACCTGGAAAACAAGCGTCCTCTGCACCTCTCTTTATGCTGGATCTCTACAATGCCATGACCAATGAAGAAAATCCTGAAGAGTCG
GAGTACTCAGTAAGGGCATCCTTGGCAGAAGAGACCAGAGGGGCAAGAAAGGGATACCCAGCCTCTCCCAATGGGTATCCTCGTCGCATA
CAGTTATCTCGGACGACTCCTCTGACCACCCAGAGTCCTCCTCTAGCCAGCCTCCATGATACCAACTTTCTGAATGATGCTGACATGGTC
ATGAGCTTTGTCAACTTAGGGAGAAGCAGGATCCCCTGGTGCTCCGGGGCAGGATGGAACACGGGGAGAGCCTGGAATCCCAGGATTTCC
TGGAAACCGAGGATTAATGGGCCAAAAGGGAGAAATTGGGCCTCCAGGACAGCAAGGAAAAAAAGGAGCCCCAGGGATGCCTGGTTTAAT
GGGAAGCAATGGCTCACCAGGCCAGCCTGGAACACCGGGATCTAAGGGAAGCAAAGGTGAACCTGGAATTCAAGGGATGCCTGGGGCTTC
TGGGCTCAAGGGAGAACCAGGAGCAACGGGTTCCCCAGGAGAACCAGGATACATGGGTTTACCCGGGATTCAAGGAAAAAAGGGGGACAA
AGGAAATCAAGGTGAAAAAGGTATTCAGGGTCAAAAGGGAGAAAATGGAAGACAGGGAATTCCAGGGCAACAGGGAATTCAAGGCCATCA
TGGTGCAAAAGGAGAGAGAGGTGAAAAGGGAGAACCTGGTGTCCGAGGTGCCATTGGATCAAAAGGAGAATCTGGGGTGGATGGCTTGAT
GGGGCCCGCAGGTCCTAAGGGGCAACCTGGGGATCCAGGTCCTCAGGGACCCCCAGGTTTGGATGGGAAGCCCGGAAGAGAGTTTTCAGA
ACAATTTATTCGACAAGTTTGCACAGATGTAATAAGAGCCCAGCTACCAGTCTTACTTCAGAGTGGAAGAATTAGAAATTGTGATCATTG
CCTGTCCCAACATGGCTCCCCGGGTATTCCTGGGCCACCTGGTCCGATAGGCCCAGAGGGTCCCAGAGGATTACCTGGTTTGCCAGGAAG
AGATGGTGTTCCTGGATTAGTGGGTGTCCCTGGACGTCCAGGTGTCAGAGGATTAAAAGGCCTACCAGGAAGAAATGGGGAAAAAGGGAG
CCAAGGGTTTGGGTATCCTGGAGAACAAGGTCCTCCTGGTCCCCCAGGTCCAGAGGGCCCTCCTGGAATAAGCAAAGAAGGTCCTCCAGG
AGACCCAGGTCTCCCTGGCAAAGATGGAGACCATGGAAAACCTGGAATCCAAGGGCAACCAGGCCCCCCAGGCATCTGCGACCCATCACT
ATGTTTTAGTGTAATTGCCAGAAGAGATCCGTTCAGAAAAGGACCAAACTATTAGTGTCTGATGCCTCATTCAGCAGCCTAGGCATGGTG
CTTTTTCTGTGGTCTTTTGCATCTCAGGAAGATAACCAACAGTAATCCCTTGAAAAGAAACTTAAGTACCTCGGTGTTTTTATTTTTTTT
TTCTTATGGAAAAAAATATAAAAGATCACATATACTGATTTTAAAGGCTCCTCAGTCATTTGGAGCCCTTGGATTAGCAGCATTAATTAA
ATCTCAAGGGTTTCTTGTAAAGTCCATTTATGTTAATCAAAGTTGAATATAAAAATCCACCATTGCCTGTTAGCCAGTCAGTTTTAGTCA
CTGTGAAATATTTCACATTCAGCCTCCATGCAGTAGAGATTTGAGTTTAATTTCATGTCCATGTGACTTTCATGTTTCCTATCTCATAGC
TCATGCTACTACATAAGCCAAAACATGTATCTCATCATTGGAAGTAAGATCAGGGCTGATATTCACCTGGGATAGACAGTATTGGTGAAC
TACTCATTTACTACAGTGTCTCAGCCTTGATAAGGGGCAGTGGATTGCCTGTTGTTCGGTGTTGTGAATAGCACCTCTGAATAAGATTAG
AGTGTTTCTTAATTCATTTCAAACTCTAAAATTAGATTAATGGTGGTGCTAAGAAAGAGTATTAATTACTTTGGGAATGGTCAAAATTAA
CATTAAAAACATTTTAGACAAAAAGTTTCATTGTACATTCAAAGAAAATGTAAGTTTGGAAGTACTAAAAGACTATTTTATACTTGTTGA
TTAATCGGAATGTTTGTTGTATGCCTTCATTTTCCATTTCACTTATATGTGTATGTCCATATATGTTAATTTTCATTGTAGCAAAGCTAA
TGGAAATAAAGCTAATGCTCTAGTTGAAAGAAAAGGAAAACTCCTGAAATCCTAGAATGTCTTGTTATTTTTAGCTGACTGTAAAATATT
ATGAACAGTCTTTGTGTATTGTGCTTAATGCTTTTGTAAGAAACAGAATTTGAAATATTTCATCCTTGTCATGCTCAAAATTTTGTTACA

>9870_9870_3_BMP5-COL21A1_BMP5_chr6_55739174_ENST00000370830_COL21A1_chr6_55966323_ENST00000535941_length(amino acids)=342AA_BP=
MGQKGEIGPPGQQGKKGAPGMPGLMGSNGSPGQPGTPGSKGSKGEPGIQGMPGASGLKGEPGATGSPGEPGYMGLPGIQGKKGDKGNQGE
KGIQGQKGENGRQGIPGQQGIQGHHGAKGERGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQ
VCTDVIRAQLPVLLQSGRIRNCDHCLSQHGSPGIPGPPGPIGPEGPRGLPGLPGRDGVPGLVGVPGRPGVRGLKGLPGRNGEKGSQGFGY

--------------------------------------------------------------
>9870_9870_4_BMP5-COL21A1_BMP5_chr6_55739174_ENST00000446683_COL21A1_chr6_55966323_ENST00000244728_length(transcript)=2687nt_BP=504nt
GCTTTTGGACAAAAATGCATCTGACTGTATTTTTACTTAAGGGTATTGTGGGTTTCCTCTGGAGCTGCTGGGTTCTAGTGGGTTATGCAA
AAGGAGGTTTGGGAGACAATCATGTTCACTCCAGTTTTATTTATAGAAGACTACGGAACCACGAAAGACGGGAAATACAAAGGGAAATTC
TCTCTATCTTGGGTTTGCCTCACAGACCCAGACCATTTTCACCTGGAAAACAAGCGTCCTCTGCACCTCTCTTTATGCTGGATCTCTACA
ATGCCATGACCAATGAAGAAAATCCTGAAGAGTCGGAGTACTCAGTAAGGGCATCCTTGGCAGAAGAGACCAGAGGGGCAAGAAAGGGAT
ACCCAGCCTCTCCCAATGGGTATCCTCGTCGCATACAGTTATCTCGGACGACTCCTCTGACCACCCAGAGTCCTCCTCTAGCCAGCCTCC
ATGATACCAACTTTCTGAATGATGCTGACATGGTCATGAGCTTTGTCAACTTAGGGAGAAGCAGGATCCCCTGGTGCTCCGGGGCAGGAT
GGAACACGGGGAGAGCCTGGAATCCCAGGATTTCCTGGAAACCGAGGATTAATGGGCCAAAAGGGAGAAATTGGGCCTCCAGGACAGCAA
GGAAAAAAAGGAGCCCCAGGGATGCCTGGTTTAATGGGAAGCAATGGCTCACCAGGCCAGCCTGGAACACCGGGATCTAAGGGAAGCAAA
GGTGAACCTGGAATTCAAGGGATGCCTGGGGCTTCTGGGCTCAAGGGAGAACCAGGAGCAACGGGTTCCCCAGGAGAACCAGGATACATG
GGTTTACCCGGGATTCAAGGAAAAAAGGGGGACAAAGGAAATCAAGGTGAAAAAGGTATTCAGGGTCAAAAGGGAGAAAATGGAAGACAG
GGAATTCCAGGGCAACAGGGAATTCAAGGCCATCATGGTGCAAAAGGAGAGAGAGGTGAAAAGGGAGAACCTGGTGTCCGAGGTGCCATT
GGATCAAAAGGAGAATCTGGGGTGGATGGCTTGATGGGGCCCGCAGGTCCTAAGGGGCAACCTGGGGATCCAGGTCCTCAGGGACCCCCA
GGTTTGGATGGGAAGCCCGGAAGAGAGTTTTCAGAACAATTTATTCGACAAGTTTGCACAGATGTAATAAGAGCCCAGCTACCAGTCTTA
CTTCAGAGTGGAAGAATTAGAAATTGTGATCATTGCCTGTCCCAACATGGCTCCCCGGGTATTCCTGGGCCACCTGGTCCGATAGGCCCA
GAGGGTCCCAGAGGATTACCTGGTTTGCCAGGAAGAGATGGTGTTCCTGGATTAGTGGGTGTCCCTGGACGTCCAGGTGTCAGAGGATTA
AAAGGCCTACCAGGAAGAAATGGGGAAAAAGGGAGCCAAGGGTTTGGGTATCCTGGAGAACAAGGTCCTCCTGGTCCCCCAGGTCCAGAG
GGCCCTCCTGGAATAAGCAAAGAAGGTCCTCCAGGAGACCCAGGTCTCCCTGGCAAAGATGGAGACCATGGAAAACCTGGAATCCAAGGG
CAACCAGGCCCCCCAGGCATCTGCGACCCATCACTATGTTTTAGTGTAATTGCCAGAAGAGATCCGTTCAGAAAAGGACCAAACTATTAG
TGTCTGATGCCTCATTCAGCAGCCTAGGCATGGTGCTTTTTCTGTGGTCTTTTGCATCTCAGGAAGATAACCAACAGTAATCCCTTGAAA
AGAAACTTAAGTACCTCGGTGTTTTTATTTTTTTTTTCTTATGGAAAAAAATATAAAAGATCACATATACTGATTTTAAAGGCTCCTCAG
TCATTTGGAGCCCTTGGATTAGCAGCATTAATTAAATCTCAAGGGTTTCTTGTAAAGTCCATTTATGTTAATCAAAGTTGAATATAAAAA
TCCACCATTGCCTGTTAGCCAGTCAGTTTTAGTCACTGTGAAATATTTCACATTCAGCCTCCATGCAGTAGAGATTTGAGTTTAATTTCA
TGTCCATGTGACTTTCATGTTTCCTATCTCATAGCTCATGCTACTACATAAGCCAAAACATGTATCTCATCATTGGAAGTAAGATCAGGG
CTGATATTCACCTGGGATAGACAGTATTGGTGAACTACTCATTTACTACAGTGTCTCAGCCTTGATAAGGGGCAGTGGATTGCCTGTTGT
TCGGTGTTGTGAATAGCACCTCTGAATAAGATTAGAGTGTTTCTTAATTCATTTCAAACTCTAAAATTAGATTAATGGTGGTGCTAAGAA
AGAGTATTAATTACTTTGGGAATGGTCAAAATTAACATTAAAAACATTTTAGACAAAAAGTTTCATTGTACATTCAAAGAAAATGTAAGT
TTGGAAGTACTAAAAGACTATTTTATACTTGTTGATTAATCGGAATGTTTGTTGTATGCCTTCATTTTCCATTTCACTTATATGTGTATG
TCCATATATGTTAATTTTCATTGTAGCAAAGCTAATGGAAATAAAGCTAATGCTCTAGTTGAAAGAAAAGGAAAACTCCTGAAATCCTAG
AATGTCTTGTTATTTTTAGCTGACTGTAAAATATTATGAACAGTCTTTGTGTATTGTGCTTAATGCTTTTGTAAGAAACAGAATTTGAAA

>9870_9870_4_BMP5-COL21A1_BMP5_chr6_55739174_ENST00000446683_COL21A1_chr6_55966323_ENST00000244728_length(amino acids)=342AA_BP=
MGQKGEIGPPGQQGKKGAPGMPGLMGSNGSPGQPGTPGSKGSKGEPGIQGMPGASGLKGEPGATGSPGEPGYMGLPGIQGKKGDKGNQGE
KGIQGQKGENGRQGIPGQQGIQGHHGAKGERGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQ
VCTDVIRAQLPVLLQSGRIRNCDHCLSQHGSPGIPGPPGPIGPEGPRGLPGLPGRDGVPGLVGVPGRPGVRGLKGLPGRNGEKGSQGFGY

--------------------------------------------------------------
>9870_9870_5_BMP5-COL21A1_BMP5_chr6_55739174_ENST00000446683_COL21A1_chr6_55966323_ENST00000370819_length(transcript)=2687nt_BP=504nt
GCTTTTGGACAAAAATGCATCTGACTGTATTTTTACTTAAGGGTATTGTGGGTTTCCTCTGGAGCTGCTGGGTTCTAGTGGGTTATGCAA
AAGGAGGTTTGGGAGACAATCATGTTCACTCCAGTTTTATTTATAGAAGACTACGGAACCACGAAAGACGGGAAATACAAAGGGAAATTC
TCTCTATCTTGGGTTTGCCTCACAGACCCAGACCATTTTCACCTGGAAAACAAGCGTCCTCTGCACCTCTCTTTATGCTGGATCTCTACA
ATGCCATGACCAATGAAGAAAATCCTGAAGAGTCGGAGTACTCAGTAAGGGCATCCTTGGCAGAAGAGACCAGAGGGGCAAGAAAGGGAT
ACCCAGCCTCTCCCAATGGGTATCCTCGTCGCATACAGTTATCTCGGACGACTCCTCTGACCACCCAGAGTCCTCCTCTAGCCAGCCTCC
ATGATACCAACTTTCTGAATGATGCTGACATGGTCATGAGCTTTGTCAACTTAGGGAGAAGCAGGATCCCCTGGTGCTCCGGGGCAGGAT
GGAACACGGGGAGAGCCTGGAATCCCAGGATTTCCTGGAAACCGAGGATTAATGGGCCAAAAGGGAGAAATTGGGCCTCCAGGACAGCAA
GGAAAAAAAGGAGCCCCAGGGATGCCTGGTTTAATGGGAAGCAATGGCTCACCAGGCCAGCCTGGAACACCGGGATCTAAGGGAAGCAAA
GGTGAACCTGGAATTCAAGGGATGCCTGGGGCTTCTGGGCTCAAGGGAGAACCAGGAGCAACGGGTTCCCCAGGAGAACCAGGATACATG
GGTTTACCCGGGATTCAAGGAAAAAAGGGGGACAAAGGAAATCAAGGTGAAAAAGGTATTCAGGGTCAAAAGGGAGAAAATGGAAGACAG
GGAATTCCAGGGCAACAGGGAATTCAAGGCCATCATGGTGCAAAAGGAGAGAGAGGTGAAAAGGGAGAACCTGGTGTCCGAGGTGCCATT
GGATCAAAAGGAGAATCTGGGGTGGATGGCTTGATGGGGCCCGCAGGTCCTAAGGGGCAACCTGGGGATCCAGGTCCTCAGGGACCCCCA
GGTTTGGATGGGAAGCCCGGAAGAGAGTTTTCAGAACAATTTATTCGACAAGTTTGCACAGATGTAATAAGAGCCCAGCTACCAGTCTTA
CTTCAGAGTGGAAGAATTAGAAATTGTGATCATTGCCTGTCCCAACATGGCTCCCCGGGTATTCCTGGGCCACCTGGTCCGATAGGCCCA
GAGGGTCCCAGAGGATTACCTGGTTTGCCAGGAAGAGATGGTGTTCCTGGATTAGTGGGTGTCCCTGGACGTCCAGGTGTCAGAGGATTA
AAAGGCCTACCAGGAAGAAATGGGGAAAAAGGGAGCCAAGGGTTTGGGTATCCTGGAGAACAAGGTCCTCCTGGTCCCCCAGGTCCAGAG
GGCCCTCCTGGAATAAGCAAAGAAGGTCCTCCAGGAGACCCAGGTCTCCCTGGCAAAGATGGAGACCATGGAAAACCTGGAATCCAAGGG
CAACCAGGCCCCCCAGGCATCTGCGACCCATCACTATGTTTTAGTGTAATTGCCAGAAGAGATCCGTTCAGAAAAGGACCAAACTATTAG
TGTCTGATGCCTCATTCAGCAGCCTAGGCATGGTGCTTTTTCTGTGGTCTTTTGCATCTCAGGAAGATAACCAACAGTAATCCCTTGAAA
AGAAACTTAAGTACCTCGGTGTTTTTATTTTTTTTTTCTTATGGAAAAAAATATAAAAGATCACATATACTGATTTTAAAGGCTCCTCAG
TCATTTGGAGCCCTTGGATTAGCAGCATTAATTAAATCTCAAGGGTTTCTTGTAAAGTCCATTTATGTTAATCAAAGTTGAATATAAAAA
TCCACCATTGCCTGTTAGCCAGTCAGTTTTAGTCACTGTGAAATATTTCACATTCAGCCTCCATGCAGTAGAGATTTGAGTTTAATTTCA
TGTCCATGTGACTTTCATGTTTCCTATCTCATAGCTCATGCTACTACATAAGCCAAAACATGTATCTCATCATTGGAAGTAAGATCAGGG
CTGATATTCACCTGGGATAGACAGTATTGGTGAACTACTCATTTACTACAGTGTCTCAGCCTTGATAAGGGGCAGTGGATTGCCTGTTGT
TCGGTGTTGTGAATAGCACCTCTGAATAAGATTAGAGTGTTTCTTAATTCATTTCAAACTCTAAAATTAGATTAATGGTGGTGCTAAGAA
AGAGTATTAATTACTTTGGGAATGGTCAAAATTAACATTAAAAACATTTTAGACAAAAAGTTTCATTGTACATTCAAAGAAAATGTAAGT
TTGGAAGTACTAAAAGACTATTTTATACTTGTTGATTAATCGGAATGTTTGTTGTATGCCTTCATTTTCCATTTCACTTATATGTGTATG
TCCATATATGTTAATTTTCATTGTAGCAAAGCTAATGGAAATAAAGCTAATGCTCTAGTTGAAAGAAAAGGAAAACTCCTGAAATCCTAG
AATGTCTTGTTATTTTTAGCTGACTGTAAAATATTATGAACAGTCTTTGTGTATTGTGCTTAATGCTTTTGTAAGAAACAGAATTTGAAA

>9870_9870_5_BMP5-COL21A1_BMP5_chr6_55739174_ENST00000446683_COL21A1_chr6_55966323_ENST00000370819_length(amino acids)=342AA_BP=
MGQKGEIGPPGQQGKKGAPGMPGLMGSNGSPGQPGTPGSKGSKGEPGIQGMPGASGLKGEPGATGSPGEPGYMGLPGIQGKKGDKGNQGE
KGIQGQKGENGRQGIPGQQGIQGHHGAKGERGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQ
VCTDVIRAQLPVLLQSGRIRNCDHCLSQHGSPGIPGPPGPIGPEGPRGLPGLPGRDGVPGLVGVPGRPGVRGLKGLPGRNGEKGSQGFGY

--------------------------------------------------------------
>9870_9870_6_BMP5-COL21A1_BMP5_chr6_55739174_ENST00000446683_COL21A1_chr6_55966323_ENST00000535941_length(transcript)=2686nt_BP=504nt
GCTTTTGGACAAAAATGCATCTGACTGTATTTTTACTTAAGGGTATTGTGGGTTTCCTCTGGAGCTGCTGGGTTCTAGTGGGTTATGCAA
AAGGAGGTTTGGGAGACAATCATGTTCACTCCAGTTTTATTTATAGAAGACTACGGAACCACGAAAGACGGGAAATACAAAGGGAAATTC
TCTCTATCTTGGGTTTGCCTCACAGACCCAGACCATTTTCACCTGGAAAACAAGCGTCCTCTGCACCTCTCTTTATGCTGGATCTCTACA
ATGCCATGACCAATGAAGAAAATCCTGAAGAGTCGGAGTACTCAGTAAGGGCATCCTTGGCAGAAGAGACCAGAGGGGCAAGAAAGGGAT
ACCCAGCCTCTCCCAATGGGTATCCTCGTCGCATACAGTTATCTCGGACGACTCCTCTGACCACCCAGAGTCCTCCTCTAGCCAGCCTCC
ATGATACCAACTTTCTGAATGATGCTGACATGGTCATGAGCTTTGTCAACTTAGGGAGAAGCAGGATCCCCTGGTGCTCCGGGGCAGGAT
GGAACACGGGGAGAGCCTGGAATCCCAGGATTTCCTGGAAACCGAGGATTAATGGGCCAAAAGGGAGAAATTGGGCCTCCAGGACAGCAA
GGAAAAAAAGGAGCCCCAGGGATGCCTGGTTTAATGGGAAGCAATGGCTCACCAGGCCAGCCTGGAACACCGGGATCTAAGGGAAGCAAA
GGTGAACCTGGAATTCAAGGGATGCCTGGGGCTTCTGGGCTCAAGGGAGAACCAGGAGCAACGGGTTCCCCAGGAGAACCAGGATACATG
GGTTTACCCGGGATTCAAGGAAAAAAGGGGGACAAAGGAAATCAAGGTGAAAAAGGTATTCAGGGTCAAAAGGGAGAAAATGGAAGACAG
GGAATTCCAGGGCAACAGGGAATTCAAGGCCATCATGGTGCAAAAGGAGAGAGAGGTGAAAAGGGAGAACCTGGTGTCCGAGGTGCCATT
GGATCAAAAGGAGAATCTGGGGTGGATGGCTTGATGGGGCCCGCAGGTCCTAAGGGGCAACCTGGGGATCCAGGTCCTCAGGGACCCCCA
GGTTTGGATGGGAAGCCCGGAAGAGAGTTTTCAGAACAATTTATTCGACAAGTTTGCACAGATGTAATAAGAGCCCAGCTACCAGTCTTA
CTTCAGAGTGGAAGAATTAGAAATTGTGATCATTGCCTGTCCCAACATGGCTCCCCGGGTATTCCTGGGCCACCTGGTCCGATAGGCCCA
GAGGGTCCCAGAGGATTACCTGGTTTGCCAGGAAGAGATGGTGTTCCTGGATTAGTGGGTGTCCCTGGACGTCCAGGTGTCAGAGGATTA
AAAGGCCTACCAGGAAGAAATGGGGAAAAAGGGAGCCAAGGGTTTGGGTATCCTGGAGAACAAGGTCCTCCTGGTCCCCCAGGTCCAGAG
GGCCCTCCTGGAATAAGCAAAGAAGGTCCTCCAGGAGACCCAGGTCTCCCTGGCAAAGATGGAGACCATGGAAAACCTGGAATCCAAGGG
CAACCAGGCCCCCCAGGCATCTGCGACCCATCACTATGTTTTAGTGTAATTGCCAGAAGAGATCCGTTCAGAAAAGGACCAAACTATTAG
TGTCTGATGCCTCATTCAGCAGCCTAGGCATGGTGCTTTTTCTGTGGTCTTTTGCATCTCAGGAAGATAACCAACAGTAATCCCTTGAAA
AGAAACTTAAGTACCTCGGTGTTTTTATTTTTTTTTTCTTATGGAAAAAAATATAAAAGATCACATATACTGATTTTAAAGGCTCCTCAG
TCATTTGGAGCCCTTGGATTAGCAGCATTAATTAAATCTCAAGGGTTTCTTGTAAAGTCCATTTATGTTAATCAAAGTTGAATATAAAAA
TCCACCATTGCCTGTTAGCCAGTCAGTTTTAGTCACTGTGAAATATTTCACATTCAGCCTCCATGCAGTAGAGATTTGAGTTTAATTTCA
TGTCCATGTGACTTTCATGTTTCCTATCTCATAGCTCATGCTACTACATAAGCCAAAACATGTATCTCATCATTGGAAGTAAGATCAGGG
CTGATATTCACCTGGGATAGACAGTATTGGTGAACTACTCATTTACTACAGTGTCTCAGCCTTGATAAGGGGCAGTGGATTGCCTGTTGT
TCGGTGTTGTGAATAGCACCTCTGAATAAGATTAGAGTGTTTCTTAATTCATTTCAAACTCTAAAATTAGATTAATGGTGGTGCTAAGAA
AGAGTATTAATTACTTTGGGAATGGTCAAAATTAACATTAAAAACATTTTAGACAAAAAGTTTCATTGTACATTCAAAGAAAATGTAAGT
TTGGAAGTACTAAAAGACTATTTTATACTTGTTGATTAATCGGAATGTTTGTTGTATGCCTTCATTTTCCATTTCACTTATATGTGTATG
TCCATATATGTTAATTTTCATTGTAGCAAAGCTAATGGAAATAAAGCTAATGCTCTAGTTGAAAGAAAAGGAAAACTCCTGAAATCCTAG
AATGTCTTGTTATTTTTAGCTGACTGTAAAATATTATGAACAGTCTTTGTGTATTGTGCTTAATGCTTTTGTAAGAAACAGAATTTGAAA

>9870_9870_6_BMP5-COL21A1_BMP5_chr6_55739174_ENST00000446683_COL21A1_chr6_55966323_ENST00000535941_length(amino acids)=342AA_BP=
MGQKGEIGPPGQQGKKGAPGMPGLMGSNGSPGQPGTPGSKGSKGEPGIQGMPGASGLKGEPGATGSPGEPGYMGLPGIQGKKGDKGNQGE
KGIQGQKGENGRQGIPGQQGIQGHHGAKGERGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQ
VCTDVIRAQLPVLLQSGRIRNCDHCLSQHGSPGIPGPPGPIGPEGPRGLPGLPGRDGVPGLVGVPGRPGVRGLKGLPGRNGEKGSQGFGY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BMP5-COL21A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for BMP5-COL21A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for BMP5-COL21A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource