FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:WARS-EPB41L4B (FusionGDB2 ID:98710)

Fusion Gene Summary for WARS-EPB41L4B

check button Fusion gene summary
Fusion gene informationFusion gene name: WARS-EPB41L4B
Fusion gene ID: 98710
HgeneTgene
Gene symbol

WARS

EPB41L4B

Gene ID

7453

54566

Gene nametryptophanyl-tRNA synthetase 1erythrocyte membrane protein band 4.1 like 4B
SynonymsGAMMA-2|HMN9|IFI53|IFP53|WARSCG1|EHM2|LULU2
Cytomap

14q32.2

9q31.3

Type of geneprotein-codingprotein-coding
Descriptiontryptophan--tRNA ligase, cytoplasmicepididymis secretory sperm binding proteinhWRSinterferon-induced protein 53trpRStryptophan tRNA ligase 1, cytoplasmicband 4.1-like protein 4BFERM-containing protein CG1
Modification date2020031320200313
UniProtAcc.

Q9H329

Ensembl transtripts involved in fusion geneENST00000355338, ENST00000392882, 
ENST00000557135, ENST00000344102, 
ENST00000556645, ENST00000358655, 
ENST00000554084, 		ENST00000374557, 
ENST00000374566, 
Fusion gene scores* DoF score13 X 17 X 6=132610 X 10 X 4=400
# samples 1813
** MAII scorelog2(18/1326*10)=-2.88101196378291
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/400*10)=-1.62148837674627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WARS [Title/Abstract] AND EPB41L4B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWARS(100835424)-EPB41L4B(111979425), # samples:3
Anticipated loss of major functional domain due to fusion event.WARS-EPB41L4B seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
WARS-EPB41L4B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
WARS-EPB41L4B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWARS

GO:0001933

negative regulation of protein phosphorylation

22504299

HgeneWARS

GO:0006469

negative regulation of protein kinase activity

22504299

HgeneWARS

GO:0010628

positive regulation of gene expression

22504299

HgeneWARS

GO:0010835

regulation of protein ADP-ribosylation

22504299

HgeneWARS

GO:0045765

regulation of angiogenesis

11773625|11773626

TgeneEPB41L4B

GO:0031032

actomyosin structure organization

22006950

TgeneEPB41L4B

GO:0042060

wound healing

23664528


check buttonFusion gene breakpoints across WARS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EPB41L4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-IN-AB1X-01AWARSchr14

100835424

-EPB41L4Bchr9

111979425

-
ChimerDB4STADTCGA-IN-AB1X-01AWARSchr14

100841620

-EPB41L4Bchr9

111979425

-
ChimerDB4STADTCGA-IN-AB1XWARSchr14

100835423

-EPB41L4Bchr9

111976098

-
ChimerDB4STADTCGA-IN-AB1XWARSchr14

100835423

-EPB41L4Bchr9

111979425

-
ChimerDB4STADTCGA-IN-AB1XWARSchr14

100841619

-EPB41L4Bchr9

111979425

-


Top

Fusion Gene ORF analysis for WARS-EPB41L4B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000355338ENST00000374557WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
5CDS-intronENST00000355338ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
5CDS-intronENST00000355338ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111979425

-
5CDS-intronENST00000392882ENST00000374557WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
5CDS-intronENST00000392882ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
5CDS-intronENST00000392882ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111979425

-
5CDS-intronENST00000557135ENST00000374557WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
5CDS-intronENST00000557135ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
5CDS-intronENST00000557135ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111979425

-
5UTR-3CDSENST00000344102ENST00000374566WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
5UTR-3CDSENST00000344102ENST00000374566WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
5UTR-3CDSENST00000392882ENST00000374566WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
5UTR-3CDSENST00000392882ENST00000374566WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
5UTR-3CDSENST00000556645ENST00000374566WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
5UTR-3CDSENST00000556645ENST00000374566WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
5UTR-3CDSENST00000557135ENST00000374566WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
5UTR-3CDSENST00000557135ENST00000374566WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
5UTR-intronENST00000344102ENST00000374557WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
5UTR-intronENST00000344102ENST00000374557WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
5UTR-intronENST00000392882ENST00000374557WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
5UTR-intronENST00000392882ENST00000374557WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
5UTR-intronENST00000556645ENST00000374557WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
5UTR-intronENST00000556645ENST00000374557WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
5UTR-intronENST00000557135ENST00000374557WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
5UTR-intronENST00000557135ENST00000374557WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
Frame-shiftENST00000355338ENST00000374566WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
Frame-shiftENST00000355338ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111979425

-
Frame-shiftENST00000392882ENST00000374566WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
Frame-shiftENST00000392882ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
Frame-shiftENST00000392882ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111979425

-
Frame-shiftENST00000557135ENST00000374566WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
Frame-shiftENST00000557135ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111979425

-
In-frameENST00000355338ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
In-frameENST00000557135ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
intron-3CDSENST00000344102ENST00000374566WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
intron-3CDSENST00000344102ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
intron-3CDSENST00000344102ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111979425

-
intron-3CDSENST00000355338ENST00000374566WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
intron-3CDSENST00000355338ENST00000374566WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
intron-3CDSENST00000358655ENST00000374566WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
intron-3CDSENST00000358655ENST00000374566WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
intron-3CDSENST00000358655ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
intron-3CDSENST00000358655ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111979425

-
intron-3CDSENST00000358655ENST00000374566WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
intron-3CDSENST00000554084ENST00000374566WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
intron-3CDSENST00000554084ENST00000374566WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
intron-3CDSENST00000554084ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
intron-3CDSENST00000554084ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111979425

-
intron-3CDSENST00000554084ENST00000374566WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
intron-3CDSENST00000556645ENST00000374566WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
intron-3CDSENST00000556645ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
intron-3CDSENST00000556645ENST00000374566WARSchr14

100835423

-EPB41L4Bchr9

111979425

-
intron-intronENST00000344102ENST00000374557WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
intron-intronENST00000344102ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
intron-intronENST00000344102ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111979425

-
intron-intronENST00000355338ENST00000374557WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
intron-intronENST00000355338ENST00000374557WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
intron-intronENST00000358655ENST00000374557WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
intron-intronENST00000358655ENST00000374557WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
intron-intronENST00000358655ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
intron-intronENST00000358655ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111979425

-
intron-intronENST00000358655ENST00000374557WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
intron-intronENST00000554084ENST00000374557WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
intron-intronENST00000554084ENST00000374557WARSchr14

100841620

-EPB41L4Bchr9

111979425

-
intron-intronENST00000554084ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
intron-intronENST00000554084ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111979425

-
intron-intronENST00000554084ENST00000374557WARSchr14

100841619

-EPB41L4Bchr9

111979425

-
intron-intronENST00000556645ENST00000374557WARSchr14

100835424

-EPB41L4Bchr9

111979425

-
intron-intronENST00000556645ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111976098

-
intron-intronENST00000556645ENST00000374557WARSchr14

100835423

-EPB41L4Bchr9

111979425

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355338WARSchr14100835423-ENST00000374566EPB41L4Bchr9111976098-43677187201787355
ENST00000557135WARSchr14100835423-ENST00000374566EPB41L4Bchr9111976098-40163673691436355

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355338ENST00000374566WARSchr14100835423-EPB41L4Bchr9111976098-0.0547121060.94528794
ENST00000557135ENST00000374566WARSchr14100835423-EPB41L4Bchr9111976098-0.057171590.94282836

Top

Fusion Genomic Features for WARS-EPB41L4B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for WARS-EPB41L4B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:100835424/chr9:111979425)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EPB41L4B

Q9H329

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927). {ECO:0000250|UniProtKB:Q9JMC8, ECO:0000269|PubMed:14521927, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:23664528}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEPB41L4Bchr14:100835423chr9:111976098ENST00000374557016504_5170519.0Compositional biasNote=His-rich
TgeneEPB41L4Bchr14:100835423chr9:111976098ENST0000037455701685_3690519.0DomainFERM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWARSchr14:100835423chr9:111976098ENST00000344102-1108_640431.0DomainWHEP-TRS
HgeneWARSchr14:100835423chr9:111976098ENST00000355338-2118_6433472.0DomainWHEP-TRS
HgeneWARSchr14:100835423chr9:111976098ENST00000358655-1108_640431.0DomainWHEP-TRS
HgeneWARSchr14:100835423chr9:111976098ENST00000392882-2118_6433472.0DomainWHEP-TRS
HgeneWARSchr14:100835423chr9:111976098ENST00000556645-1118_640431.0DomainWHEP-TRS
HgeneWARSchr14:100835423chr9:111976098ENST00000557135-3128_6433472.0DomainWHEP-TRS
HgeneWARSchr14:100835423chr9:111976098ENST00000344102-110164_1730431.0MotifNote='HIGH' region
HgeneWARSchr14:100835423chr9:111976098ENST00000344102-110349_3530431.0MotifNote='KMSKS' region
HgeneWARSchr14:100835423chr9:111976098ENST00000355338-211164_17333472.0MotifNote='HIGH' region
HgeneWARSchr14:100835423chr9:111976098ENST00000355338-211349_35333472.0MotifNote='KMSKS' region
HgeneWARSchr14:100835423chr9:111976098ENST00000358655-110164_1730431.0MotifNote='HIGH' region
HgeneWARSchr14:100835423chr9:111976098ENST00000358655-110349_3530431.0MotifNote='KMSKS' region
HgeneWARSchr14:100835423chr9:111976098ENST00000392882-211164_17333472.0MotifNote='HIGH' region
HgeneWARSchr14:100835423chr9:111976098ENST00000392882-211349_35333472.0MotifNote='KMSKS' region
HgeneWARSchr14:100835423chr9:111976098ENST00000556645-111164_1730431.0MotifNote='HIGH' region
HgeneWARSchr14:100835423chr9:111976098ENST00000556645-111349_3530431.0MotifNote='KMSKS' region
HgeneWARSchr14:100835423chr9:111976098ENST00000557135-312164_17333472.0MotifNote='HIGH' region
HgeneWARSchr14:100835423chr9:111976098ENST00000557135-312349_35333472.0MotifNote='KMSKS' region
TgeneEPB41L4Bchr14:100835423chr9:111976098ENST000003745661526504_517544901.0Compositional biasNote=His-rich
TgeneEPB41L4Bchr14:100835423chr9:111976098ENST00000374566152685_369544901.0DomainFERM


Top

Fusion Gene Sequence for WARS-EPB41L4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98710_98710_1_WARS-EPB41L4B_WARS_chr14_100835423_ENST00000355338_EPB41L4B_chr9_111976098_ENST00000374566_length(transcript)=4367nt_BP=718nt
TGTCAAGCCCTATGCTGGGTCTGGTGTGGGTGGAAATCAAACACAAAACACAGATCCCCCCGGAGGCCCCAGAGCGATGAAAGCAACAAA
CAAGATACGACCAGAGATGGGTTTTGAAGGATGAATAGGAGTTAGCTGAGCTGTCAATAGTAAGAAGTAAGGTTGGTCCAAGGCACAGCG
CTTTCTGAAGGAACAGGAAGTGAAAGGAAGGCGAGCGGCTATGAGAGACCGCGTTAAGCGGCACGGGGCGCTTTAGGCGCTGCCCAGTCC
CGGCCCCTCCAGCCCGGGGCCCGCCGCTCACCACACGCACCGGAAGCGCTCGGTTCTCCCGGAGGCAGACCGGCCAGCACACTACCATCC
AGTCACGTTCCGACGCGACGCCGCGGCCGCCAGCCAATCAGTGGCGGCCTCTGCCCCGCCCCCGCGCGAACAGCCAATGACGGCGCCGTC
GGGCCGGAAGTTGTTCCGTCCGGACGGCGTTTCCACGGACGCCCAGGAGACAGCCGGTTGCTGAGCCGGGAGCGCTGACTGGCCCGGCTG
GGCAGGTCTTGACTCGTCTGCTGAACAAATCCTCTGACCTCAGGCCGGCTGTGAACGTAGTTCCTGAGAGATAGCAAACATGCCCAACAG
TGAGCCCGCATCTCTGCTGGAGCTGTTCAACAGCATCGCCACACAAGGGGAGCTCGTAAGGTCCCTCAAAGCGGGAAATGCGTCAAAGAA
CTGAGTCCAGGAACACCTGCCTTGTTCAGTGAAGCCGCTGCCCATCTAAAGAAGCTGGAACTGGAAACTGTGAAGGCTGCTGGACCCTGG
CCTCCTCTGCACATCAACATAAACAAGGCTGAAGAAAAGAAAGTCTCGGAGAAAACTCTTCAGACTCCACTTTTGCCTTCCCCTGTTGCG
GATCATGTGAAGTGTAACATTCTGAAAGCCCAGTTGGAAAATGCTTCCCGAGTGAACATCCAGGGTGGAAAGGAGGAATCACCGTTTGTA
AATATCAATAAGAAATCCAGTCTTCAGGACGCTAGTGTAAGAAGTCCTATTCCTATTCGTGTGGAAACTGCCCAGCCAGCTGTGGAAAAG
CCGGAAATCAAGCCTCCCCGAGTGAGGAAGTTAACAAGACAGTATAGTTTTGATGAAGACGACCTCCCTCCAGACCTGGCCGAGGCAGTG
GGAGTGACCACATCTACAACCACAAACACCACAACGGCCGCCACACAAGTCTCCGTGCCGCTGCCGTCCCCCAAGGTCCAGAATGTCAGC
TCGCCTCACAAGTCAGAAGGCAAAGGCCTGCTGTCCCCTGGGGCCAAGAGCCCCTCTGACCGAGGAGGTGCCTTTACCCTGGAGCCGGGT
GATCTTCTGATGGATTTCACAGAAGCCACTCCTCTGGCAGAGCCCGCCAGCAACCCCCACTGTGCCCACTCTCGCTGTTCTCCTCCACTC
TCTCTCCCCATGAAGGAAGAGACCACTGGAGTTTGCATGTACCCTCCAATCAAAACGAGGCTGATAAAAACATTCCCGGTTGATACAATG
AACCCGTTTCCTGATACTTTCACCACAGGGCCACAGTTTACTGCAGACTTCAGAGACAGTAAATTACAGTGCTGTCCTGGCCCGACTTCC
CCGCTGATCCCAGCAGCGACCCTGAGGCCTTTGACAGAGACCGTCTCCACAGTGCAGACCATTTACACCACCCGGAAACCTGTTTCTCTG
GCAGCCAGTGCAGAGACACTCCGGCAGGAACTGGAGAGAGAGAAGATGATGAAAAGACTGTTGATGACCGAACTGTGAAATTCTCCCCTT
GTCACCTGGAAGATGGCATGGTGCCTTCTGTCCGTCTTCTTTCTTCGGGCTTTGTGTGCTCACTCTAGCACAGCATACAAGTGTGTGCTC
TGTTCGCCCAGGTCTCCATGGTTAGTTGAAGCCAATTTCTGGCTTGACTTTTATGGGAAAAGTTATTTTATGTCTCCTAAGCATTAGAGT
TTTTCTATTACTCTATGTAGTTGAGACAGGATTTGATAAGTCTAGGAAAAGAAAGATGGGAAAACGGGATTCCTTTTCAGAAGTACCTGT
GTGTATCTGTTAATAACCACAGGGGTTAATATGATGTAGGATCTTTTACTATCAATTTCAACCATTTGATTTTGTATGATTGAAACTTGC
ACCGAGCTTTGACTGTTTGTTAAAGAGTCATTTTTAATGAAAGAATAATTCTTTATTGCTGGTTTTTCATTTACACTGATAAATACACAG
ATCTTATAAAGTCTTTAACATTCATTTGTATTCAGATGTGAGTAGAAGAACTAAAAAAAGAAAGTTACATATCACTATGACTGAAGGTAC
TTCAGCTTAATCTGAAATATAATTTAACTTGTGAACTCCTTGGATATGATATTATTTGGAATAAACAGAATTTATCATTGAACCCAAAGT
AGGAAATGATAGCTTACATTGTCTAAAAATCCTTACAAGGTTAAGATGATTCAATATCAAGAAGATTCAGAAAATTATTTCTAAAGTTGA
TCGATTCATGTCGTATTGATAGAATCTTGACCAGAAGAAATTTTGCTCTTTTTATATAGTTTCAAGAAATGTGTTTTTAAATTTTTATTA
ATGCACTTGAACAACTTTGCAGGAATAAAGCAACCCCCTAACCACAAAATATCCCTCTAAATTAGTTCCCTAGCTTTCTCAATGAATACA
CACATATTTTTACATAGCTATGATCGTTGTGTACATTCTCCTTTGTTTTACTTCTCGGCCTAACACTTGTCTCCTCTTGTCAACACAGAT
TCTACTCTCACCAATTTAAATGTCTTTATATCCATGTAACATGGGTAACCTCACTTCACCCCATTATTAGATATTTGAGTTATATCTAAT
TTTTCACTCTTATAAATAGTGCTGCTATGAATGTCTGTAAAAAAAAAAAACTGCTCCTTCTTTTGGATTATTCCCTTAGGAATATCTCCA
AAGAGGGATTACAAGGTCAAAGAGCATGAAGTATTTTATAGCTCTTGTTTTATATTGCCAGATTGCTTTCTAGAAAGATCCAATCTTTGG
GTTGGAAGGACCTTAAAGGTCATCTAGTTTAGCCTCCCCACCCCCTCTGAATGCTTGAATCCCCTCGACAATTTATGATGCCACCAGCAA
TGTATAAGCATTTCTGTTTACCAATAGCTCTGCCAGTATTGGGTTTTGCCATTTTTATTTATTTTTGCTAGTTTAATAGGTATGTATAGT
TGTTCTTGAAGAGTTGTTTTATTTCATTAATTGCTAGCAAGGCTGAGCACTTTTCCATGTGATGATTTACTAGTTGTATTTCCTTGTGTG
TAAAATGTTCATTCATTTCTTATGACCACTTGTTAAGAGGAACTGATCTCATATATTTGTATCAGAACTGTATTTTTATGTTATATTGTA
TAGTTTGCTCTCCTGCCCCTCTCCTTAAAACTGAATGGTGCCAATAATTTGATACTAATGACTACAAAAAAAGGTAATGCCTCATTTACT
AGTATTGTTGTAAAATGAGGAATGTATGTGAATATTCAGATAACCGAGGATTAACCCTTTAAGTGCTGAATCTTTAAAATTTTAATATAT
TTTTTTTTGAGGGAAATCTTTCTAAAATGTATTACGCACTTCCCTGCCTTAGTAAACAGAGTATACTGGAGAGTATTTAACCTTTTCTTG
ATGAGTCATGGTCATGATTATAAACATCAGCCCCTTTTATACCTTGGTACGGTGCAGTGATATCATTAAGAGCTATCAATATGTGTAGGG
CTTGGCTTGGCCTTTTATAGGATATTATGCTGTTCTCACTGATGGTTTTTTACTGCTCTCTGCTCTGTCAGTGGAGCTATCCGGGGCAAT
TGTAGCGTTTGGGTCCTTTTACCCCTATGTCCCCCGGCTATACTTTTAAAACAGCTTTAGCTGTTCTTTATCTTGTGCACATGATACAAA
ATATGTTCCCGTACAATATGGGGCTGTCACTTCTTGCCAACCCAGCACCCTCTTCCTCTTCTAACCTGCTTTCTGAGGCTTCTGCTCTTC
ACCTCCTGCTCGCTGATGGAAACCTCCAGGGCAAAGCTGAAGGTTTCTTGGGGAAGCCAGGAAAGCCAGTATTTCCTATGTGTCAGATCT
GCTTGGCTTCCAAGAAGGGATGCATGGGCTTTTTGGCCAGTGTTTCCAGGAGGCTCTGGGCTTCCTGCTTCTTCCCCGCTTCCCCCAGAG
TTCACAGATGTTGAAGTTTCTGAAGGTTGACGTCACTGGAAGTCTGACCACAAACAAGTTGGCTGTTACTGTATTTGAAACCCAGTACCT

>98710_98710_1_WARS-EPB41L4B_WARS_chr14_100835423_ENST00000355338_EPB41L4B_chr9_111976098_ENST00000374566_length(amino acids)=355AA_BP=1
MSPGTPALFSEAAAHLKKLELETVKAAGPWPPLHININKAEEKKVSEKTLQTPLLPSPVADHVKCNILKAQLENASRVNIQGGKEESPFV
NINKKSSLQDASVRSPIPIRVETAQPAVEKPEIKPPRVRKLTRQYSFDEDDLPPDLAEAVGVTTSTTTNTTTAATQVSVPLPSPKVQNVS
SPHKSEGKGLLSPGAKSPSDRGGAFTLEPGDLLMDFTEATPLAEPASNPHCAHSRCSPPLSLPMKEETTGVCMYPPIKTRLIKTFPVDTM

--------------------------------------------------------------
>98710_98710_2_WARS-EPB41L4B_WARS_chr14_100835423_ENST00000557135_EPB41L4B_chr9_111976098_ENST00000374566_length(transcript)=4016nt_BP=367nt
ACTCTCAGCAGCTCAACTGCCCAGCGTGACCAGTGGCCACCTCTGCAGTGTCTTCCACAACCTGGAGTGTACTATTTGTTAAACAGGTGA
ATCTACTTCTCTTAACAAAGTCTCAATGTCCTATTTGCAATTTATGTGGTAAACACTGAAGACAATGGTCCTTAACCTTTTGGCATCTCA
GCCTCCTTTCGAAAGTCTTGACTCGTCTGCTGAACAAATCCTCTGACCTCAGGCCGGCTGTGAACGTAGTTCCTGAGAGATAGCAAACAT
GCCCAACAGTGAGCCCGCATCTCTGCTGGAGCTGTTCAACAGCATCGCCACACAAGGGGAGCTCGTAAGGTCCCTCAAAGCGGGAAATGC
GTCAAAGAACTGAGTCCAGGAACACCTGCCTTGTTCAGTGAAGCCGCTGCCCATCTAAAGAAGCTGGAACTGGAAACTGTGAAGGCTGCT
GGACCCTGGCCTCCTCTGCACATCAACATAAACAAGGCTGAAGAAAAGAAAGTCTCGGAGAAAACTCTTCAGACTCCACTTTTGCCTTCC
CCTGTTGCGGATCATGTGAAGTGTAACATTCTGAAAGCCCAGTTGGAAAATGCTTCCCGAGTGAACATCCAGGGTGGAAAGGAGGAATCA
CCGTTTGTAAATATCAATAAGAAATCCAGTCTTCAGGACGCTAGTGTAAGAAGTCCTATTCCTATTCGTGTGGAAACTGCCCAGCCAGCT
GTGGAAAAGCCGGAAATCAAGCCTCCCCGAGTGAGGAAGTTAACAAGACAGTATAGTTTTGATGAAGACGACCTCCCTCCAGACCTGGCC
GAGGCAGTGGGAGTGACCACATCTACAACCACAAACACCACAACGGCCGCCACACAAGTCTCCGTGCCGCTGCCGTCCCCCAAGGTCCAG
AATGTCAGCTCGCCTCACAAGTCAGAAGGCAAAGGCCTGCTGTCCCCTGGGGCCAAGAGCCCCTCTGACCGAGGAGGTGCCTTTACCCTG
GAGCCGGGTGATCTTCTGATGGATTTCACAGAAGCCACTCCTCTGGCAGAGCCCGCCAGCAACCCCCACTGTGCCCACTCTCGCTGTTCT
CCTCCACTCTCTCTCCCCATGAAGGAAGAGACCACTGGAGTTTGCATGTACCCTCCAATCAAAACGAGGCTGATAAAAACATTCCCGGTT
GATACAATGAACCCGTTTCCTGATACTTTCACCACAGGGCCACAGTTTACTGCAGACTTCAGAGACAGTAAATTACAGTGCTGTCCTGGC
CCGACTTCCCCGCTGATCCCAGCAGCGACCCTGAGGCCTTTGACAGAGACCGTCTCCACAGTGCAGACCATTTACACCACCCGGAAACCT
GTTTCTCTGGCAGCCAGTGCAGAGACACTCCGGCAGGAACTGGAGAGAGAGAAGATGATGAAAAGACTGTTGATGACCGAACTGTGAAAT
TCTCCCCTTGTCACCTGGAAGATGGCATGGTGCCTTCTGTCCGTCTTCTTTCTTCGGGCTTTGTGTGCTCACTCTAGCACAGCATACAAG
TGTGTGCTCTGTTCGCCCAGGTCTCCATGGTTAGTTGAAGCCAATTTCTGGCTTGACTTTTATGGGAAAAGTTATTTTATGTCTCCTAAG
CATTAGAGTTTTTCTATTACTCTATGTAGTTGAGACAGGATTTGATAAGTCTAGGAAAAGAAAGATGGGAAAACGGGATTCCTTTTCAGA
AGTACCTGTGTGTATCTGTTAATAACCACAGGGGTTAATATGATGTAGGATCTTTTACTATCAATTTCAACCATTTGATTTTGTATGATT
GAAACTTGCACCGAGCTTTGACTGTTTGTTAAAGAGTCATTTTTAATGAAAGAATAATTCTTTATTGCTGGTTTTTCATTTACACTGATA
AATACACAGATCTTATAAAGTCTTTAACATTCATTTGTATTCAGATGTGAGTAGAAGAACTAAAAAAAGAAAGTTACATATCACTATGAC
TGAAGGTACTTCAGCTTAATCTGAAATATAATTTAACTTGTGAACTCCTTGGATATGATATTATTTGGAATAAACAGAATTTATCATTGA
ACCCAAAGTAGGAAATGATAGCTTACATTGTCTAAAAATCCTTACAAGGTTAAGATGATTCAATATCAAGAAGATTCAGAAAATTATTTC
TAAAGTTGATCGATTCATGTCGTATTGATAGAATCTTGACCAGAAGAAATTTTGCTCTTTTTATATAGTTTCAAGAAATGTGTTTTTAAA
TTTTTATTAATGCACTTGAACAACTTTGCAGGAATAAAGCAACCCCCTAACCACAAAATATCCCTCTAAATTAGTTCCCTAGCTTTCTCA
ATGAATACACACATATTTTTACATAGCTATGATCGTTGTGTACATTCTCCTTTGTTTTACTTCTCGGCCTAACACTTGTCTCCTCTTGTC
AACACAGATTCTACTCTCACCAATTTAAATGTCTTTATATCCATGTAACATGGGTAACCTCACTTCACCCCATTATTAGATATTTGAGTT
ATATCTAATTTTTCACTCTTATAAATAGTGCTGCTATGAATGTCTGTAAAAAAAAAAAACTGCTCCTTCTTTTGGATTATTCCCTTAGGA
ATATCTCCAAAGAGGGATTACAAGGTCAAAGAGCATGAAGTATTTTATAGCTCTTGTTTTATATTGCCAGATTGCTTTCTAGAAAGATCC
AATCTTTGGGTTGGAAGGACCTTAAAGGTCATCTAGTTTAGCCTCCCCACCCCCTCTGAATGCTTGAATCCCCTCGACAATTTATGATGC
CACCAGCAATGTATAAGCATTTCTGTTTACCAATAGCTCTGCCAGTATTGGGTTTTGCCATTTTTATTTATTTTTGCTAGTTTAATAGGT
ATGTATAGTTGTTCTTGAAGAGTTGTTTTATTTCATTAATTGCTAGCAAGGCTGAGCACTTTTCCATGTGATGATTTACTAGTTGTATTT
CCTTGTGTGTAAAATGTTCATTCATTTCTTATGACCACTTGTTAAGAGGAACTGATCTCATATATTTGTATCAGAACTGTATTTTTATGT
TATATTGTATAGTTTGCTCTCCTGCCCCTCTCCTTAAAACTGAATGGTGCCAATAATTTGATACTAATGACTACAAAAAAAGGTAATGCC
TCATTTACTAGTATTGTTGTAAAATGAGGAATGTATGTGAATATTCAGATAACCGAGGATTAACCCTTTAAGTGCTGAATCTTTAAAATT
TTAATATATTTTTTTTTGAGGGAAATCTTTCTAAAATGTATTACGCACTTCCCTGCCTTAGTAAACAGAGTATACTGGAGAGTATTTAAC
CTTTTCTTGATGAGTCATGGTCATGATTATAAACATCAGCCCCTTTTATACCTTGGTACGGTGCAGTGATATCATTAAGAGCTATCAATA
TGTGTAGGGCTTGGCTTGGCCTTTTATAGGATATTATGCTGTTCTCACTGATGGTTTTTTACTGCTCTCTGCTCTGTCAGTGGAGCTATC
CGGGGCAATTGTAGCGTTTGGGTCCTTTTACCCCTATGTCCCCCGGCTATACTTTTAAAACAGCTTTAGCTGTTCTTTATCTTGTGCACA
TGATACAAAATATGTTCCCGTACAATATGGGGCTGTCACTTCTTGCCAACCCAGCACCCTCTTCCTCTTCTAACCTGCTTTCTGAGGCTT
CTGCTCTTCACCTCCTGCTCGCTGATGGAAACCTCCAGGGCAAAGCTGAAGGTTTCTTGGGGAAGCCAGGAAAGCCAGTATTTCCTATGT
GTCAGATCTGCTTGGCTTCCAAGAAGGGATGCATGGGCTTTTTGGCCAGTGTTTCCAGGAGGCTCTGGGCTTCCTGCTTCTTCCCCGCTT
CCCCCAGAGTTCACAGATGTTGAAGTTTCTGAAGGTTGACGTCACTGGAAGTCTGACCACAAACAAGTTGGCTGTTACTGTATTTGAAAC

>98710_98710_2_WARS-EPB41L4B_WARS_chr14_100835423_ENST00000557135_EPB41L4B_chr9_111976098_ENST00000374566_length(amino acids)=355AA_BP=1
MSPGTPALFSEAAAHLKKLELETVKAAGPWPPLHININKAEEKKVSEKTLQTPLLPSPVADHVKCNILKAQLENASRVNIQGGKEESPFV
NINKKSSLQDASVRSPIPIRVETAQPAVEKPEIKPPRVRKLTRQYSFDEDDLPPDLAEAVGVTTSTTTNTTTAATQVSVPLPSPKVQNVS
SPHKSEGKGLLSPGAKSPSDRGGAFTLEPGDLLMDFTEATPLAEPASNPHCAHSRCSPPLSLPMKEETTGVCMYPPIKTRLIKTFPVDTM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for WARS-EPB41L4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for WARS-EPB41L4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for WARS-EPB41L4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource