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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:WBP1L-ADAMTS2 (FusionGDB2 ID:98781)

Fusion Gene Summary for WBP1L-ADAMTS2

Fusion gene summary

Fusion gene information	Fusion gene name: WBP1L-ADAMTS2
	Fusion gene ID: 98781
		Hgene	Tgene
	Gene symbol	WBP1L	ADAMTS2
	Gene ID	54838	9509
	Gene name	WW domain binding protein 1 like	ADAM metallopeptidase with thrombospondin type 1 motif 2
	Synonyms	C10orf26\|OPA1L\|OPAL1	ADAM-TS2\|ADAMTS-2\|ADAMTS-3\|EDSDERMS\|NPI\|PC I-NP\|PCI-NP\|PCINP\|PCPNI\|PNPI
	Cytomap	10q24.32	5q35.3
	Type of gene	protein-coding	protein-coding
	Description	WW domain binding protein 1-likeoutcome predictor in acute leukemia 1	A disintegrin and metalloproteinase with thrombospondin motifs 2a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2procollagen I N-proteinaseprocollagen I/II amino propeptide-processing enzymeprocollagen N-endo
	Modification date	20200313	20200313
	UniProtAcc	Q9NX94	P59510
	Ensembl transtripts involved in fusion gene	ENST00000448841, ENST00000369889,	ENST00000251582, ENST00000274609,
Fusion gene scores	* DoF score	14 X 11 X 10=1540	6 X 6 X 3=108
	# samples	19	6
	** MAII score	log2(19/1540*10)=-3.01885902725132 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: WBP1L [Title/Abstract] AND ADAMTS2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	WBP1L(104503900)-ADAMTS2(178700065), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across WBP1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADAMTS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AO-A1KT-01A	WBP1L	chr10	104503900	+	ADAMTS2	chr5	178700065	-

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Fusion Gene ORF analysis for WBP1L-ADAMTS2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000448841	ENST00000251582	WBP1L	chr10	104503900	+	ADAMTS2	chr5	178700065	-
In-frame	ENST00000448841	ENST00000274609	WBP1L	chr10	104503900	+	ADAMTS2	chr5	178700065	-
intron-3CDS	ENST00000369889	ENST00000251582	WBP1L	chr10	104503900	+	ADAMTS2	chr5	178700065	-
intron-3CDS	ENST00000369889	ENST00000274609	WBP1L	chr10	104503900	+	ADAMTS2	chr5	178700065	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000448841

WBP1L

chr10

104503900

ENST00000251582

ADAMTS2

chr5

178700065

6292

174

3275

1063

ENST00000448841

WBP1L

chr10

104503900

ENST00000274609

ADAMTS2

chr5

178700065

1582

174

1340

418

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000448841	ENST00000251582	WBP1L	chr10	104503900	+	ADAMTS2	chr5	178700065	-	0.002162159	0.99783784
ENST00000448841	ENST00000274609	WBP1L	chr10	104503900	+	ADAMTS2	chr5	178700065	-	0.019587731	0.98041224

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Fusion Genomic Features for WBP1L-ADAMTS2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WBP1L-ADAMTS2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:104503900/chr5:178700065)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
WBP1L Q9NX94	ADAMTS2 P59510
	FUNCTION: May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000251582

185_188

178

1212.0

Compositional bias

Note=Poly-Glu

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000251582

618_722

178

1212.0

Compositional bias

Note=Cys-rich

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000274609

185_188

178

567.0

Compositional bias

Note=Poly-Glu

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000274609

618_722

178

567.0

Compositional bias

Note=Cys-rich

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000251582

1059_1097

178

1212.0

Domain

PLAC

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000251582

266_470

178

1212.0

Domain

Peptidase M12B

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000251582

480_560

178

1212.0

Domain

Note=Disintegrin

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000251582

561_616

178

1212.0

Domain

TSP type-1 1

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000251582

854_912

178

1212.0

Domain

TSP type-1 2

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000251582

914_971

178

1212.0

Domain

TSP type-1 3

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000251582

975_1029

178

1212.0

Domain

TSP type-1 4

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000274609

1059_1097

178

567.0

Domain

PLAC

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000274609

266_470

178

567.0

Domain

Peptidase M12B

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000274609

480_560

178

567.0

Domain

Note=Disintegrin

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000274609

561_616

178

567.0

Domain

TSP type-1 1

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000274609

854_912

178

567.0

Domain

TSP type-1 2

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000274609

914_971

178

567.0

Domain

TSP type-1 3

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000274609

975_1029

178

567.0

Domain

TSP type-1 4

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000251582

691_693

178

1212.0

Motif

Cell attachment site

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000274609

691_693

178

567.0

Motif

Cell attachment site

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000251582

723_851

178

1212.0

Region

Note=Spacer

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000274609

723_851

178

567.0

Region

Note=Spacer

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

WBP1L

chr10:104503900

chr5:178700065

ENST00000369889

101_183

343.0

Compositional bias

Note=Pro-rich

Hgene

WBP1L

chr10:104503900

chr5:178700065

ENST00000369889

335_342

343.0

Compositional bias

Note=Poly-Ser

Hgene

WBP1L

chr10:104503900

chr5:178700065

ENST00000448841

101_183

364.0

Compositional bias

Note=Pro-rich

Hgene

WBP1L

chr10:104503900

chr5:178700065

ENST00000448841

335_342

364.0

Compositional bias

Note=Poly-Ser

Hgene

WBP1L

chr10:104503900

chr5:178700065

ENST00000369889

42_62

343.0

Transmembrane

Helical

Hgene

WBP1L

chr10:104503900

chr5:178700065

ENST00000448841

42_62

364.0

Transmembrane

Helical

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000251582

40_43

178

1212.0

Compositional bias

Note=Poly-Ala

Tgene

ADAMTS2

chr10:104503900

chr5:178700065

ENST00000274609

40_43

178

567.0

Compositional bias

Note=Poly-Ala

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Fusion Gene Sequence for WBP1L-ADAMTS2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>98781_98781_1_WBP1L-ADAMTS2_WBP1L_chr10_104503900_ENST00000448841_ADAMTS2_chr5_178700065_ENST00000251582_length(transcript)=6292nt_BP=174nt
GAAGGAAGAAGAGGGTAGAGGAGGAGAGGGAGGAGGAGGAGGGAGGTGGCGGCGCCGTGGCGGAGGAGCAGGAGCAGGAGGGGGATGGAG
AGGAGAAGGCTCCTGGGTGGCATGGCGCTCCTGCTCCTCCAGGCGCTGCCCAGCCCCTTGTCAGCCAGGGCTGAACCCCCGCAGGCTGGT
CTGATCCGGATGGAGGAGGAGGAGTTCTTCATCGAACCCTTGGAGAAGGGGCTGGCGGCGCAGGAGGCTGAGCAAGGCCGTGTGCATGTG
GTGTATCGCCGGCCACCCACGTCCCCTCCTCTCGGGGGGCCACAGGCCCTGGACACAGGGGCCTCCCTGGACAGCCTGGACAGCCTCAGC
CGCGCCCTGGGCGTCCTAGAGGAGCACGCCAACAGCTCGAGGCGGAGGGCACGCAGGCATGCTGCGGACGATGACTACAACATCGAGGTC
CTGCTGGGCGTGGATGACTCTGTGGTGCAGTTCCACGGGAAGGAGCACGTACAGAAGTACCTGCTGACACTCATGAACATTGTCAATGAA
ATCTACCATGACGAGTCCTTGGGTGCCCACATCAACGTGGTCCTGGTGCGGATCATCCTCCTGAGCTATGGAAAGTCCATGAGCCTCATC
GAGATCGGGAACCCCTCTCAGAGCCTGGAGAATGTCTGCCGCTGGGCCTACCTCCAGCAGAAGCCAGACACGGGCCACGATGAATACCAC
GATCACGCCATCTTCCTCACACGGCAGGACTTTGGGCCTTCCGGCATGCAAGGCTATGCTCCTGTCACCGGCATGTGCCATCCGGTCCGC
AGCTGCACCCTGAACCATGAGGACGGCTTCTCCTCAGCGTTTGTGGTGGCCCATGAGACTGGCCACGTGCTGGGCATGGAGCACGACGGG
CAGGGCAACCGCTGTGGCGACGAGGTGCGGCTGGGCAGCATCATGGCGCCCCTGGTGCAGGCCGCCTTCCACCGCTTCCACTGGTCCCGC
TGCAGCCAGCAGGAGCTGAGCCGCTACCTGCACTCCTATGACTGCCTGCTGGATGACCCCTTCGCCCACGACTGGCCGGCGCTGCCCCAG
CTCCCGGGACTGCACTACTCCATGAACGAGCAATGCCGCTTTGACTTCGGCCTGGGCTACATGATGTGCACGGCGTTCCGGACCTTTGAC
CCCTGCAAGCAGCTGTGGTGCAGCCATCCTGACAACCCCTACTTTTGCAAGACCAAGAAGGGGCCCCCCTTGGACGGGACTATGTGTGCA
CCTGGCAAGCATTGTTTTAAAGGACACTGCATCTGGCTGACACCTGACATCCTCAAACGGGACGGCAGCTGGGGCGCTTGGAGTCCGTTT
GGCTCCTGCTCACGTACCTGTGGCACGGGCGTGAAGTTCAGGACCCGCCAGTGTGACAACCCACACCCGGCCAACGGGGGCCGCACCTGC
TCGGGCCTTGCCTACGACTTCCAGCTCTGCAGCCGCCAGGACTGCCCCGACTCCCTGGCTGACTTCCGCGAGGAGCAGTGCCGCCAGTGG
GACCTGTACTTCGAGCACGGCGACGCCCAGCACCACTGGCTGCCCCACGAGCACCGGGATGCCAAGGAGAGATGCCACCTGTACTGCGAG
TCCAGGGAGACCGGGGAGGTGGTGTCCATGAAGCGCATGGTGCATGACGGGACGCGCTGCTCCTACAAGGACGCCTTCAGCCTCTGTGTG
CGCGGGGACTGCAGGAAGGTGGGCTGTGACGGTGTGATCGGCTCCAGCAAGCAGGAAGACAAGTGTGGCGTGTGCGGAGGGGACAACAGC
CACTGCAAAGTGGTCAAGGGCACGTTCACACGGTCACCCAAGAAGCATGGTTACATCAAGATGTTTGAGATCCCTGCAGGAGCCAGACAC
CTGCTCATTCAGGAGGTAGACGCCACCAGCCACCATCTGGCCGTCAAGAACCTGGAGACAGGCAAGTTCATCTTAAATGAAGAGAATGAC
GTGGATGCCAGTTCCAAAACCTTCATTGCCATGGGCGTGGAGTGGGAGTACAGAGACGAGGACGGCCGGGAGACGCTGCAGACCATGGGC
CCCCTCCACGGCACCATCACCGTTCTGGTCATCCCGGTGGGAGACACCCGGGTCTCACTGACGTACAAATACATGATCCATGAGGACTCA
CTGAATGTCGACGACAACAACGTCCTGGAAGAGGACTCTGTGGTCTACGAGTGGGCCCTGAAGAAGTGGTCTCCGTGCTCCAAGCCCTGT
GGCGGAGGGTCCCAGTTCACCAAGTATGGCTGCCGCCGGAGGCTGGACCACAAGATGGTACACCGTGGCTTCTGTGCCGCCCTCTCGAAG
CCCAAAGCCATCCGCAGAGCGTGCAACCCACAGGAATGCTCCCAGCCAGTGTGGGTCACAGGCGAATGGGAGCCATGTAGCCAGACCTGT
GGGCGGACAGGCATGCAGGTGCGCTCCGTGCGCTGCATTCAGCCGCTACACGACAACACCACCCGCTCCGTGCACGCCAAGCACTGCAAT
GACGCCCGGCCCGAGAGCCGCCGGGCCTGCAGCCGCGAGCTCTGCCCTGGTCGTTGGCGAGCCGGGCCCTGGTCCCAGTGCTCAGTAACC
TGTGGCAACGGCACCCAGGAGCGGCCAGTGCTCTGCCGCACCGCGGACGACAGCTTCGGCATCTGCCAGGAGGAGCGTCCTGAGACAGCG
AGGACCTGCAGGCTTGGCCCCTGTCCCCGAAACATCTCAGATCCCTCCAAGAAGAGCTACGTAGTTCAGTGGCTGTCCCGCCCGGACCCC
GACTCGCCCATCCGGAAGATCTCGTCAAAGGGCCACTGCCAAGGCGACAAGTCAATATTCTGTAGGATGGAAGTCTTGTCCCGCTATTGC
TCCATCCCAGGCTACAACAAGCTGTGCTGCAAGTCCTGTAACCTGTACAACAACCTCACCAACGTGGAGGGCAGGATAGAGCCACCGCCT
GGGAAGCACAACGACATTGACGTGTTCATGCCTACCCTCCCAGTGCCCACTGTAGCCATGGAGGTGCGGCCATCACCAAGCACCCCCCTG
GAGGTCCCTCTCAATGCCTCCAGCACCAATGCCACAGAGGATCACCCAGAAACCAATGCCGTAGATGAACCCTACAAAATCCATGGCCTG
GAAGATGAAGTCCAGCCACCCAACCTAATCCCTCGACGACCGAGCCCCTATGAAAAGACCAGAAACCAAAGAATCCAAGAGCTCATTGAT
GAGATGCGGAAGAAAGAGATGCTCGGAAAGTTCTAATAAAATGGAAAGATAGCATCCCTAGCATTTTTTTCTTGCTTATAGAGATATTCC
ATGGGATAGCAAATCCTGTGTCATGGAGATGAAGTCAAAATTCCTGATTCCAAAAGGTTTTGAGAAAACAAAGAGGGGGAATGACGTAAG
AAAGATAGGCATGAGCATGTGGTAACTAGGTTAGCACGTGTGCTTCCCAGCCCAGGAGCGACCAAATACTGTGGTGGCGTCAGGTGTGCA
GTGGAGAGGAATATAGAGGCTGTATGGCCTCCCTCAGTGAGGGCAGGGCAAGAGGGATCACTCTGAGAGAACAAAAATAGGCCCCAAGTT
GCTAAGCAGTGATTGGGAACCTTCCTTTCCTTGGCGGAGATGCATGACATTCCCTACCGATCCCCAGACACAGCCTGTGGGACTCTTAGG
AGAAATGGTGATTTACTGAATAACTGACCCGTTGCCGAGATGAGTACAATGAAGTGGAGGTGATGAACTCAAATCGTCTTCCAGGGCCAG
GCGGCTGACCGGGGTGAGCGTAGTGGCCCGCTGGGGACCATGGCCGCCCTGACAGCCACACCCACCTGGAGCTGACTTGGTTCTGGCTGT
TGCTGCCACTGTGAAATCTGTATCTCTCTCCATCTCTGCTCTACTATCCCCGGCCTTGCCAGACAGTGTTCTTTTTCGGAAGAAGTCTAG
ATTTTTGCATGAAAAAAACTCAATCTTTAAAGGTCGACTCAGAACATTTTAAGGAGGCCTCCACTTGGTCTGATGCAGTCTTGCTAATTA
AGAACTAAAGGCCTTCTGACCTTCTTGGTGCTCATGCTGTACGGCATCTGAATGTCTCGACCGAGTCTGAGCCGTGCAGCTGTCCTCCAC
CTGCGAAAGTAATGAGAATCCTATCACGGGACATAAGGATAGGTCTAAACAGGGTCCATGCCAAGAAAACAGTGGGGTGCTCTCCCAGGC
CTCTCCCCTGTCCACTAACCCTGGCCTTGCCGGCTGCCTTCCAGGCTCTGGGGGAAGAGCTCCTGCATTCTTCCCTGGCCACCTTGGCTC
CAGGGCTCCCCAGAGAGCCTCTTCCCTCCCCAAGTACCTGAGAAAGATGAGAGAGGCACGTGCTCTGCTGGGAAGGTCCAGTGAGCGGTT
CAAGGGCCTGGAATCTCCCTACGGCCAAGTCTAAGGGTTCTGGGATTCTGGGCTTTGTGGGCTTTGCTTGCTTGCTGGGAATGGGCTTTC
CCTGTCCCGCCCTGCCCCACCTCGCCTCTGTCTCTCAGAAGCTCCAGAACCCAGCAGTGACCTGCAAAATGTGGCCTCTGATGGGGGCTT
AGGGTGGGAGATGGGGAGAGCCTACATTGTCTTTTGCTCCTTGAAAACTTTAATAGCTCCTATTTTCCAGAGAATGGTGCTTTGTGAGCA
ACATGCGAGTAAGAGAGAAATAGGAGGAAGGGGGAGTAGGGGCGGATGGGAGAAGAGTGGCTCATTTTTACCTCTCACTGCCTTGACATT
TTGTGAACGTGAAGCTTAAACTTTCTGGGCTTACAAGACCCAGGGGCACGTCAGCTCCTTAGATGGGCTCAGCCTGACACATAATTCTTA
AACCTTTCCTGTTTAAGAAACTTCTAGAGGCTGTGTACTCTCACCAATCCTCTTCGAGAATTTGTTCATGTGTATTTCCCCATTATATGG
ATGAGGCTCAGGATAACAGCATAGTGGCTACCTTCTACTGAGTTTTGAGGTGCTAATAAGTATGTTTGTCTGAGGCTGCACATGTGGGTG
GCTCTGTGTGTATGATCCAAGGGACAAAATGACGATGTAGGAACCAGCAAGAACGGAATCTGGGCTGATGCTTCAGTCTCCACCTGGGTG
ATGGCTAGCCTCCCGCCCTCCACCACCGCATCCCACACGTGCTGCGCACTGTCCCCGTGTCTCCTGGAGAACCAAACTGGAGAAAACCTT
TCTGAGTATCTCTCATAGTACCCCTTCCTTAAGAAGATGTGGTTTAGAGCATGTGTGCAATCCTGCCTCTGTAATTAGGAAACGGAGCCC
GAGGCTTTCCATTGTTGGTTGAACCCAGGACAGCTGGTGCTATTCACAGGCTGAAGAACTGGGCAGTTCTTACTTGGGTCTGTCCTAGGA
TGTGGAGGAAGTTCAGGACTAACGCTAGGCAGAGAGTATGACTCGGTTTACCCAGCCTAGGGGCCTCTGGATGGGAACACTCCATTCCAA
GATCTCAGCAGAGCAGGGCTTCCTGGCTTGAGGCTGGAAGCCTTTGGGAAGAGGCCCAGCTGGGACATTCCCTGGGCACCTGTCTTCCGC
TGAAGGGAGCAAGGTGCCCTCTGGGACTGACAGCCATGACCCTCTGTGCCATCCTCAATCCTTGAGCCATATATCAAGAGTCCTCTAGAG
CCGGATGGTCCTCAAAAGTCTGTCCAAGGAATGCCAACGTTCACCGGGCTCTGAGAAACGACGCAAATCTCTGAGCTGGGGACCACTTGG
AGAACCGGCTTAGTAACAGTCCTGATCTTCGCAAGCCAGCTTCTTCTGCATCTGAGGGGCTCCTGGCGCCCAGAGGAGGCAGACAGATGT
CTTCTAGCTGAGTTTCTAACCGCATGATGAGACTCAGACCTTCCGCTGCACTAGAAAATCTGCAACAGTGTCCCTGAGTCACTTCTCCTT
AGTGGGCAGACTCGTGTTAGATTTGTGGAACCCAGCTCTCTGATTTACTCCTTTTGGAAAACCCATGGAATTTCATGTATAAGGCTTTCA
TTTGTATTTTAAGGTTTTTCTGTTTGTTTTGAGTATATACATGGTGCTCAATAGCAACATCTTAGCAGATGAAGCAGTTTATGATTCCAC
TCCCTCCTGTATGACAGGTAGCCACTATACTGAATCAAGGTGCTGAACTCAAATCACAAAATTCTGGCTTACCGATACAACAACCAATAC

>98781_98781_1_WBP1L-ADAMTS2_WBP1L_chr10_104503900_ENST00000448841_ADAMTS2_chr5_178700065_ENST00000251582_length(amino acids)=1063AA_BP=28
MERRRLLGGMALLLLQALPSPLSARAEPPQAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDS
LSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMS
LIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEH
DGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRT
FDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGR
TCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSL
CVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEE
NDVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSK
PCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKH
CNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPCPRNISDPSKKSYVVQWLSRP
DPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPST

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>98781_98781_2_WBP1L-ADAMTS2_WBP1L_chr10_104503900_ENST00000448841_ADAMTS2_chr5_178700065_ENST00000274609_length(transcript)=1582nt_BP=174nt
GAAGGAAGAAGAGGGTAGAGGAGGAGAGGGAGGAGGAGGAGGGAGGTGGCGGCGCCGTGGCGGAGGAGCAGGAGCAGGAGGGGGATGGAG
AGGAGAAGGCTCCTGGGTGGCATGGCGCTCCTGCTCCTCCAGGCGCTGCCCAGCCCCTTGTCAGCCAGGGCTGAACCCCCGCAGGCTGGT
CTGATCCGGATGGAGGAGGAGGAGTTCTTCATCGAACCCTTGGAGAAGGGGCTGGCGGCGCAGGAGGCTGAGCAAGGCCGTGTGCATGTG
GTGTATCGCCGGCCACCCACGTCCCCTCCTCTCGGGGGGCCACAGGCCCTGGACACAGGGGCCTCCCTGGACAGCCTGGACAGCCTCAGC
CGCGCCCTGGGCGTCCTAGAGGAGCACGCCAACAGCTCGAGGCGGAGGGCACGCAGGCATGCTGCGGACGATGACTACAACATCGAGGTC
CTGCTGGGCGTGGATGACTCTGTGGTGCAGTTCCACGGGAAGGAGCACGTACAGAAGTACCTGCTGACACTCATGAACATTGTCAATGAA
ATCTACCATGACGAGTCCTTGGGTGCCCACATCAACGTGGTCCTGGTGCGGATCATCCTCCTGAGCTATGGAAAGTCCATGAGCCTCATC
GAGATCGGGAACCCCTCTCAGAGCCTGGAGAATGTCTGCCGCTGGGCCTACCTCCAGCAGAAGCCAGACACGGGCCACGATGAATACCAC
GATCACGCCATCTTCCTCACACGGCAGGACTTTGGGCCTTCCGGCATGCAAGGCTATGCTCCTGTCACCGGCATGTGCCATCCGGTCCGC
AGCTGCACCCTGAACCATGAGGACGGCTTCTCCTCAGCGTTTGTGGTGGCCCATGAGACTGGCCACGTGCTGGGCATGGAGCACGACGGG
CAGGGCAACCGCTGTGGCGACGAGGTGCGGCTGGGCAGCATCATGGCGCCCCTGGTGCAGGCCGCCTTCCACCGCTTCCACTGGTCCCGC
TGCAGCCAGCAGGAGCTGAGCCGCTACCTGCACTCCTATGACTGCCTGCTGGATGACCCCTTCGCCCACGACTGGCCGGCGCTGCCCCAG
CTCCCGGGACTGCACTACTCCATGAACGAGCAATGCCGCTTTGACTTCGGCCTGGGCTACATGATGTGCACGGCGTTCCGGACCTTTGAC
CCCTGCAAGCAGCTGTGGTGCAGCCATCCTGACAACCCCTACTTTTGCAAGACCAAGAAGGGGCCCCCCTTGGACGGGACTATGTGTGCA
CCTGGCAAGTTCAGGCCGGGCGCGGTGGCTCATGCCTGTTATCCCAGCACTTTGGGAGGCCAAGGTAGGTGGATCGCCTGAGGTCAGAAG
TTCAAGACAAGTCTGGTTAACATGGCAAAATCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGCGGTGGTGGGTGCCTGTAATCCC
AGCTACTCCGGAGGCTGAGGCATGAAAATCGTTTGAGCCCAGGAGGCGGAGGTTGCGGTGAGCCAAGATCGCGTCGCTGCTCTCCAGTCT

>98781_98781_2_WBP1L-ADAMTS2_WBP1L_chr10_104503900_ENST00000448841_ADAMTS2_chr5_178700065_ENST00000274609_length(amino acids)=418AA_BP=28
MERRRLLGGMALLLLQALPSPLSARAEPPQAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDS
LSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMS
LIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEH
DGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRT

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Fusion Gene PPI Analysis for WBP1L-ADAMTS2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for WBP1L-ADAMTS2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for WBP1L-ADAMTS2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source