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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WBP1L-BMS1 (FusionGDB2 ID:98784)

Fusion Gene Summary for WBP1L-BMS1

check button Fusion gene summary
Fusion gene informationFusion gene name: WBP1L-BMS1
Fusion gene ID: 98784
HgeneTgene
Gene symbol

WBP1L

BMS1

Gene ID

54838

9790

Gene nameWW domain binding protein 1 likeBMS1 ribosome biogenesis factor
SynonymsC10orf26|OPA1L|OPAL1ACC|BMS1L
Cytomap

10q24.32

10q11.21

Type of geneprotein-codingprotein-coding
DescriptionWW domain binding protein 1-likeoutcome predictor in acute leukemia 1ribosome biogenesis protein BMS1 homologBMS1 homolog, ribosome assembly proteinBMS1-like, ribosome assembly proteinribosome assembly protein BMS1 homolog
Modification date2020031320200313
UniProtAcc

Q9NX94

Q14692

Ensembl transtripts involved in fusion geneENST00000448841, ENST00000369889, 
ENST00000374518, 
Fusion gene scores* DoF score14 X 11 X 10=15406 X 6 X 3=108
# samples 196
** MAII scorelog2(19/1540*10)=-3.01885902725132
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WBP1L [Title/Abstract] AND BMS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWBP1L(104503900)-BMS1(43312766), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across WBP1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BMS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8365-01AWBP1Lchr10

104503900

+BMS1chr10

43312766

+


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Fusion Gene ORF analysis for WBP1L-BMS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000448841ENST00000374518WBP1Lchr10

104503900

+BMS1chr10

43312766

+
intron-3CDSENST00000369889ENST00000374518WBP1Lchr10

104503900

+BMS1chr10

43312766

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000448841WBP1Lchr10104503900+ENST00000374518BMS1chr1043312766+5461174841619511

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448841ENST00000374518WBP1Lchr10104503900+BMS1chr1043312766+0.0001355350.99986446

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Fusion Genomic Features for WBP1L-BMS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WBP1Lchr10104503900+BMS1chr1043312765+1.37E-060.99999857
WBP1Lchr10104503900+BMS1chr1043312765+1.37E-060.99999857

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for WBP1L-BMS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:104503900/chr10:43312766)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WBP1L

Q9NX94

BMS1

Q14692

FUNCTION: May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus. {ECO:0000250|UniProtKB:Q08965}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWBP1Lchr10:104503900chr10:43312766ENST00000369889+14101_1830343.0Compositional biasNote=Pro-rich
HgeneWBP1Lchr10:104503900chr10:43312766ENST00000369889+14335_3420343.0Compositional biasNote=Poly-Ser
HgeneWBP1Lchr10:104503900chr10:43312766ENST00000448841+14101_18330364.0Compositional biasNote=Pro-rich
HgeneWBP1Lchr10:104503900chr10:43312766ENST00000448841+14335_34230364.0Compositional biasNote=Poly-Ser
HgeneWBP1Lchr10:104503900chr10:43312766ENST00000369889+1442_620343.0TransmembraneHelical
HgeneWBP1Lchr10:104503900chr10:43312766ENST00000448841+1442_6230364.0TransmembraneHelical
TgeneBMS1chr10:104503900chr10:43312766ENST00000374518132380_2458011283.0DomainBms1-type G
TgeneBMS1chr10:104503900chr10:43312766ENST000003745181323117_1218011283.0RegionG2
TgeneBMS1chr10:104503900chr10:43312766ENST000003745181323132_1358011283.0RegionG3
TgeneBMS1chr10:104503900chr10:43312766ENST000003745181323184_1878011283.0RegionG4
TgeneBMS1chr10:104503900chr10:43312766ENST000003745181323219_2288011283.0RegionG5
TgeneBMS1chr10:104503900chr10:43312766ENST00000374518132389_968011283.0RegionG1


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Fusion Gene Sequence for WBP1L-BMS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98784_98784_1_WBP1L-BMS1_WBP1L_chr10_104503900_ENST00000448841_BMS1_chr10_43312766_ENST00000374518_length(transcript)=5461nt_BP=174nt
GAAGGAAGAAGAGGGTAGAGGAGGAGAGGGAGGAGGAGGAGGGAGGTGGCGGCGCCGTGGCGGAGGAGCAGGAGCAGGAGGGGGATGGAG
AGGAGAAGGCTCCTGGGTGGCATGGCGCTCCTGCTCCTCCAGGCGCTGCCCAGCCCCTTGTCAGCCAGGGCTGAACCCCCGCAGAATGAA
GATATAGAGAAAGAAGTTAAGGAAGAAATTGACCCCGACGAAGAAGAAAGTGCCAAGAAAAAGCATTTGGATAAGAAGAGAAAATTGAAG
GAGATGTTTGATGCAGAATATGATGAAGGAGAAAGCACATATTTTGATGATCTTAAAGGAGAAATGCAGAAACAAGCACAGCTGAATCGC
GCAGAATTTGAAGATCAAGATGATGAAGCCAGAGTTCAGTATGAGGGTTTTCGACCTGGGATGTACGTCCGCATTGAGATTGAAAATGTT
CCCTGTGAATTTGTGCAGAACTTTGACCCCCATTACCCCATTATCCTGGGTGGCTTGGGCAACAGTGAGGGAAATGTTGGCTACGTGCAG
ATGCGTCTGAAGAAACATCGCTGGTATAAGAAAATCCTCAAGTCCCGAGATCCAATCATATTTTCTGTAGGGTGGAGGAGGTTTCAGACC
ATCCCACTGTATTATATCGAAGACCACAATGGAAGACAAAGGCTTCTAAAGTATACCCCACAGCACATGCATTGCGGAGCAGCCTTTTGG
GGCCCTATCACTCCACAGGGAACTGGTTTCTTGGCAATACAGTCTGTCAGTGGCATAATGCCTGATTTTCGGATAGCTGCTACAGGAGTT
GTCCTTGATCTGGATAAATCCATAAAAATTGTGAAGAAATTAAAGCTAACTGGTTTTCCATATAAAATTTTCAAGAACACTTCATTTATT
AAGGGAATGTTTAATTCTGCCTTGGAAGTGGCCAAATTTGAAGGTGCTGTGATTCGAACAGTCAGTGGGATAAGGGGGCAGATCAAGAAA
GCACTCCGAGCTCCAGAAGGAGCTTTCAGGGCCAGCTTTGAGGATAAGCTGCTGATGAGCGATATTGTCTTCATGCGAACTTGGTATCCT
GTTTCCATCCCAGCGTTCTATAACCCAGTAACATCTTTGTTGAAACCAGTGGGTGAGAAAGACACCTGGTCAGGAATGCGGACCACGGGC
CAACTCAGGCTCGCCCATGGCGTCAGACTAAAGGCGAACAAGGACTCTCTGTATAAGCCAATCCTGAGGCAAAAGAAACATTTTAATTCA
CTGCACATTCCAAAAGCCTTGCAGAAGGCCCTGCCATTTAAGAACAAGCCCAAGACCCAAGCAAAGGCAGGCAAGGTGCCAAAGGACAGG
CGGAGACCGGCCGTCATACGCGAGCCTCATGAAAGAAAGATCCTTGCACTGCTGGATGCTCTGAGTACGGTGCATAGTCAGAAGATGAAG
AAGGCCAAGGAGCAGCGGCACCTGCACAATAAAGAGCACTTCAGAGCCAAGCAGAAGGAGGAGGAGGAGAAGCTGAAGCGGCAGAAGGAC
CTCAGGAAGAAGCTCTTCAGAATTCAGGGGCAGAAGGAAAGAAGAAACCAGAAGTCCAGTTTGAAGGGGGCTGAGGGCCAATTGCAGTGA
GCCTTTGGACTGGAGGGACTGTCCCTGGATCTGCGGAGGTAGACAGTTTCAAACATCACAGTTTGAATGCCTGTGAATGACAAGTCAGTG
GGAAAGAGCTCAAGAGATGTCTCTACTCAAACTGTGCCTGCAGGAGGAGGAACAGAGAAGCCTGGGCTGCTGGGACTGGGTTCATTCTCA
TGACTTGGGGCTGTCGAGATTTAAAGTGATGTAAGCTGTGGTTATGTGGATTCTCTTACTTTCCTCTGCCTGCCTCAGTTTAATTATTTT
GTCCTACAGAAATATCATTAAAATATTTTTTTGTTACTTTTGGCTTAGTAGTTTTCATTAGGGATGAATGCCTGACAATTCTTTGTGGAT
AATTATTTATACTACCACCTTCATGAGGAGTCTTCCAGAAGAGAAAGAAATATTCACTTGAACTCTGAGCTCCCATGGAAGATTTTAGAG
AATAGTGTGTAGTGTTTTTGTTTTGTTTTTTGTTTGAGTGACACACAAACCTAGATGGTACAGCCTACTGTGCACCCAGGATCTATGGGC
TCCTTTGATCACTGGCCCTTGTGGACATTTTCTATCTTATTTCATATGTTCTGCACATTAGTATAGTGACAAGGTAACAGTAAGTACTTT
TTTAAAGCTTTAGACTTAGGAGATTATTGTCTCAGGTGCAGAGACCAAGGAAATCGTATGTATCAGTGAGATAGGCTTCCCGTATTATGC
TCATGCGTTATACCTGCCTAGCTACATTGCCTTTTTTTAAATTAAACATTATGTTGAAGTAATCATACTATTACATAGGCGATGTATGTA
TTTTATGATTGTATGTTGATATAGTTATGGGGAATCTATTCCTATACGATGTAATCATAGATTCACATATAGTTGTATATTTTGCCCAAT
TTCTCTCAGTGGTAATGTTTCACACATATAACAATCAGGATGTTGACATCAATACAGCCCGCTGATTTTATTCACATTTCCCCAGCTTTA
CTTTCCCCAACGTATACTCCTCCATGTATGCATGGGTGTGTAGAAATATGGAACGCAGCTGGGCACAGTGACTCACGCCTGTAATCCCAG
CACTTTGGGATGCTAAGGCAGGAGGATCACTTGAGCCCAGGAATTTGAGACCAACTTGGGCAACATGGCAAAACCTCATCGCTACAAAAA
ATAAAAAATTCGCCAGGTGTGGTGGGTGCACACCTGTAGTTCCAGCTGCTTGGGAGGCTGAGGTAGGAGGATCACTTGAGCTTGGGAGGT
TGAGGCTGCAGTGAGCCATGATAGCACCACTGCACTCCAGCCTGGGCGACAGGGCAAGACCCTGTTTCAAAAAAAAAAAATTATACATAT
ATGTATGTAGAACACTTCATGAATTTGTGTGTCATCTGTGCATGGGGCCCATGCTGACCTCTGTGTTGTGCCAGTTATAGTATGTGTGCT
GCTGATATGAGTGCCACATTGCCTTTACAACATCATAGGGGCCAAAGAGGGTTGGCAGGATTATGAGCAGTTGGCCTAGTCTGAGAGGCT
CTCTAAAAGCCTAAAGTCTGTAGGCAGGTGCTCAGCTTTGTATCTCCATAAGAAGGGAAGAGGATGTGAGGATCCTGTCAGGGCTAGGTC
CACCTGGGAAGTGACAATTGGAACACTCCCAGACCTCTCTGGGCAACTCTGGGTGTACATTTTCCTCTGTTCCTCAAGAGCTATTATGAA
TTTCATCATCCATTATGCTGATAGGCCTGGGGACTGACACATAGTAAGCCCATAACAATTATAATTTAAAACTAATTTGTTATATAGCAT
AATTGATATATTTTAAAATGCAAAACTATAATTCAACTAAAATATACAAGGCACTCAAGTCATACCATGTTTTAAGTAGCTTACAAGGTG
ATCAGCAAGTGTCTTATACAACAAGCAAATTTGTTCAAAGAGAAGCATTGCAAATAAGTATTTATAATTGTATAGTTTTATATTTTAGCC
AGAAGAGTGGAATCCTTTAGCAATGGGGGAAATAAAAGAATGTTTAATTACAGTTGCAGATAATTGCCTTTTCCAAAGACAATGTATGTA
GGCAGAACTCATACCTGTTAATATTAAAAATCTTGGTTTATCATATTTGGAGAACAAGGGAAATAAAAAGTTTGCATATTAAGATTATTT
AAACTAAAGTTAAGGAATCTCTAATGTCTGAAAGAAACAATAAATAGCATTTTTCATGTAGAATTTTTATTGGTGAAGGTTCCACCTGGC
CAGGTTAGTAAAATACAGTCACACATCAGTTAAGGATGGGGATATATTCTGAGAAATGTATCATTAGGCAATTTTGTCATTGTGTAAACA
TCATAGAGTGACACACAAACCTAGATGGTACAGCCTACTGTGCACCTGGGCTCTATGGTATGGCCTGTTGCTCCTAGGCTACAAACCTGG
GCAGCATGTGACTGTACTGACTACTGTAGGCAGTTGTAACACAGTGGTAAACATTTGTGTATCGAAACATAGAAAAGGCGTAGCAAAAAT
ACAGTATTGTGGAACCACTGCCATATACGTGGTCCATCCTTGACTGAACATCATGCGGCATGTGGCTGTATGTATACACATAGTTTTTGC
TGTGAGTTTGCATCCATCTCATAGGAAGACATATATCAAAATAAGGACCAGACTGGAGAGTGTGTAAATTACTTTTCAATACTAATGGCT
TATTAATTTGATATTGTCAGCAAGTATGTTGCAAAAACAAATTCCACCAGAATGTGAGTTCCATGAGAGCAGGAACTGGGTTGTTCACCT
TGTTGGCACTTGGAGTAGAGCCACTGAGCTTCGTGCTGCATAAAATTGCTTGGAAGAAAGAAGGGAGGGCATTCCAGGTAACTGAAGCAT
TGCTATGCAAAGTAAGCATTTGCCCTCTGAAATATTTTAACAATGTTTATAGAAACCTTTCTCAATTGTATTAAACTTTGTAAATTGTAA
AAATTATTCTGTTATACCTTTTCTATTTACTAGGCACAGGCAGCCATAGGTGCTAGGTATGTTTTGAAAACATATTGAACCTACAGTGTA
CATATCATTCCATGCCATTAAATATTCTTATTTAATCATAGATGTGTTCAGGTGTGTTTGGTTTCCTATTTGTGGATGTACTAGATTGTT
TTCTTTTTTTAACAAAACCTGTGAACTTGCTTTAAGTATTATCATTTGGTGACATGCCCGCCATTTCAGAAATAAATGTTTGAGCAAAGA
GGAAAGCCACCGGGTCTGATTCAGCTCTCTGGAGGCTCCAGAGCTTACCTCGCTGATGGGAAAAAGAGCATCGATTTAATTGCCCTTGGT
ACCGACTTCTAGTATCTAGTATTTTGCCAGACTCAGGTATTTCTTAAAGCCATTATTCAGAGTCTTCAGCAAGGACATTGTATTTTACTT
GTGTCTCCTTAGTTTTACCTAGTTTATTTCATGGTTTTAAAGTATTGTACATTTTTATAATCCTTTAACAAGACAAAAGGTTGAGATGTT
GGACATTTAAATGCCAAAGGTGTTTTATTATGAGACTTAGCATTTCATATTTGGGGATGGTACCTTATCGAAAATCAGATAAACTTTGGT
TGGATGGGTATTTGGAGGAATCTTTTAAGTCTTTTCTTAAGCAAAGTTTGGACACTCTAAAATAAGGTTGCCAACTGGCATGTAGAGAGA
AAAGGATGTGTCATACATTTAGACCAGGTGGCCTGTCCTGTAAATTTTTTTGAGGGGAGGGGTGGGCTTGTTTTTTTCTGTGTTTCGGTT

>98784_98784_1_WBP1L-BMS1_WBP1L_chr10_104503900_ENST00000448841_BMS1_chr10_43312766_ENST00000374518_length(amino acids)=511AA_BP=11
MERRRLLGGMALLLLQALPSPLSARAEPPQNEDIEKEVKEEIDPDEEESAKKKHLDKKRKLKEMFDAEYDEGESTYFDDLKGEMQKQAQL
NRAEFEDQDDEARVQYEGFRPGMYVRIEIENVPCEFVQNFDPHYPIILGGLGNSEGNVGYVQMRLKKHRWYKKILKSRDPIIFSVGWRRF
QTIPLYYIEDHNGRQRLLKYTPQHMHCGAAFWGPITPQGTGFLAIQSVSGIMPDFRIAATGVVLDLDKSIKIVKKLKLTGFPYKIFKNTS
FIKGMFNSALEVAKFEGAVIRTVSGIRGQIKKALRAPEGAFRASFEDKLLMSDIVFMRTWYPVSIPAFYNPVTSLLKPVGEKDTWSGMRT
TGQLRLAHGVRLKANKDSLYKPILRQKKHFNSLHIPKALQKALPFKNKPKTQAKAGKVPKDRRRPAVIREPHERKILALLDALSTVHSQK

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Fusion Gene PPI Analysis for WBP1L-BMS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WBP1L-BMS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WBP1L-BMS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource