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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WBP1L-SUFU (FusionGDB2 ID:98793)

Fusion Gene Summary for WBP1L-SUFU

check button Fusion gene summary
Fusion gene informationFusion gene name: WBP1L-SUFU
Fusion gene ID: 98793
HgeneTgene
Gene symbol

WBP1L

SUFU

Gene ID

54838

51684

Gene nameWW domain binding protein 1 likeSUFU negative regulator of hedgehog signaling
SynonymsC10orf26|OPA1L|OPAL1JBTS32|PRO1280|SUFUH|SUFUXL
Cytomap

10q24.32

10q24.32

Type of geneprotein-codingprotein-coding
DescriptionWW domain binding protein 1-likeoutcome predictor in acute leukemia 1suppressor of fused homolog
Modification date2020031320200313
UniProtAcc

Q9NX94

.
Ensembl transtripts involved in fusion geneENST00000369889, ENST00000448841, 
ENST00000471000, ENST00000369899, 
ENST00000369902, ENST00000423559, 
Fusion gene scores* DoF score14 X 11 X 10=15408 X 8 X 8=512
# samples 1912
** MAII scorelog2(19/1540*10)=-3.01885902725132
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/512*10)=-2.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WBP1L [Title/Abstract] AND SUFU [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWBP1L(104536174)-SUFU(104352338), # samples:1
WBP1L(104503900)-SUFU(104352338), # samples:1
WBP1L(104503900)-SUFU(104375025), # samples:1
WBP1L(104569811)-SUFU(104352339), # samples:1
WBP1L(104503900)-SUFU(104352339), # samples:1
WBP1L(104503899)-SUFU(104352338), # samples:1
Anticipated loss of major functional domain due to fusion event.WBP1L-SUFU seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
WBP1L-SUFU seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
WBP1L-SUFU seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSUFU

GO:0000122

negative regulation of transcription by RNA polymerase II

10564661


check buttonFusion gene breakpoints across WBP1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SUFU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-FU-A3HZ-01AWBP1Lchr10

104503900

+SUFUchr10

104375025

+
ChimerDB4GBMTCGA-27-2524-01AWBP1Lchr10

104569811

+SUFUchr10

104352339

+
ChimerDB4LUADTCGA-38-4630-01AWBP1Lchr10

104503899

+SUFUchr10

104352338

+
ChimerDB4LUADTCGA-38-4630-01AWBP1Lchr10

104503900

+SUFUchr10

104352339

+
ChimerDB4LUADTCGA-38-4630WBP1Lchr10

104503900

+SUFUchr10

104352338

+
ChimerDB4LUADTCGA-38-4630WBP1Lchr10

104536174

+SUFUchr10

104352338

+


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Fusion Gene ORF analysis for WBP1L-SUFU

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000369889ENST00000471000WBP1Lchr10

104569811

+SUFUchr10

104352339

+
5CDS-3UTRENST00000369889ENST00000471000WBP1Lchr10

104536174

+SUFUchr10

104352338

+
5CDS-3UTRENST00000448841ENST00000471000WBP1Lchr10

104569811

+SUFUchr10

104352339

+
5CDS-3UTRENST00000448841ENST00000471000WBP1Lchr10

104503899

+SUFUchr10

104352338

+
5CDS-3UTRENST00000448841ENST00000471000WBP1Lchr10

104503900

+SUFUchr10

104352339

+
5CDS-3UTRENST00000448841ENST00000471000WBP1Lchr10

104503900

+SUFUchr10

104352338

+
5CDS-intronENST00000448841ENST00000471000WBP1Lchr10

104503900

+SUFUchr10

104375025

+
Frame-shiftENST00000369889ENST00000369899WBP1Lchr10

104536174

+SUFUchr10

104352338

+
Frame-shiftENST00000369889ENST00000369902WBP1Lchr10

104536174

+SUFUchr10

104352338

+
Frame-shiftENST00000369889ENST00000423559WBP1Lchr10

104536174

+SUFUchr10

104352338

+
Frame-shiftENST00000448841ENST00000369899WBP1Lchr10

104503900

+SUFUchr10

104375025

+
Frame-shiftENST00000448841ENST00000369899WBP1Lchr10

104503899

+SUFUchr10

104352338

+
Frame-shiftENST00000448841ENST00000369899WBP1Lchr10

104503900

+SUFUchr10

104352339

+
Frame-shiftENST00000448841ENST00000369899WBP1Lchr10

104503900

+SUFUchr10

104352338

+
Frame-shiftENST00000448841ENST00000369902WBP1Lchr10

104503900

+SUFUchr10

104375025

+
Frame-shiftENST00000448841ENST00000369902WBP1Lchr10

104503899

+SUFUchr10

104352338

+
Frame-shiftENST00000448841ENST00000369902WBP1Lchr10

104503900

+SUFUchr10

104352339

+
Frame-shiftENST00000448841ENST00000369902WBP1Lchr10

104503900

+SUFUchr10

104352338

+
Frame-shiftENST00000448841ENST00000423559WBP1Lchr10

104503900

+SUFUchr10

104375025

+
Frame-shiftENST00000448841ENST00000423559WBP1Lchr10

104503899

+SUFUchr10

104352338

+
Frame-shiftENST00000448841ENST00000423559WBP1Lchr10

104503900

+SUFUchr10

104352339

+
Frame-shiftENST00000448841ENST00000423559WBP1Lchr10

104503900

+SUFUchr10

104352338

+
In-frameENST00000369889ENST00000369899WBP1Lchr10

104569811

+SUFUchr10

104352339

+
In-frameENST00000369889ENST00000369902WBP1Lchr10

104569811

+SUFUchr10

104352339

+
In-frameENST00000369889ENST00000423559WBP1Lchr10

104569811

+SUFUchr10

104352339

+
In-frameENST00000448841ENST00000369899WBP1Lchr10

104569811

+SUFUchr10

104352339

+
In-frameENST00000448841ENST00000369902WBP1Lchr10

104569811

+SUFUchr10

104352339

+
In-frameENST00000448841ENST00000423559WBP1Lchr10

104569811

+SUFUchr10

104352339

+
intron-3CDSENST00000369889ENST00000369899WBP1Lchr10

104503900

+SUFUchr10

104375025

+
intron-3CDSENST00000369889ENST00000369899WBP1Lchr10

104503899

+SUFUchr10

104352338

+
intron-3CDSENST00000369889ENST00000369899WBP1Lchr10

104503900

+SUFUchr10

104352339

+
intron-3CDSENST00000369889ENST00000369899WBP1Lchr10

104503900

+SUFUchr10

104352338

+
intron-3CDSENST00000369889ENST00000369902WBP1Lchr10

104503900

+SUFUchr10

104375025

+
intron-3CDSENST00000369889ENST00000369902WBP1Lchr10

104503899

+SUFUchr10

104352338

+
intron-3CDSENST00000369889ENST00000369902WBP1Lchr10

104503900

+SUFUchr10

104352339

+
intron-3CDSENST00000369889ENST00000369902WBP1Lchr10

104503900

+SUFUchr10

104352338

+
intron-3CDSENST00000369889ENST00000423559WBP1Lchr10

104503900

+SUFUchr10

104375025

+
intron-3CDSENST00000369889ENST00000423559WBP1Lchr10

104503899

+SUFUchr10

104352338

+
intron-3CDSENST00000369889ENST00000423559WBP1Lchr10

104503900

+SUFUchr10

104352339

+
intron-3CDSENST00000369889ENST00000423559WBP1Lchr10

104503900

+SUFUchr10

104352338

+
intron-3CDSENST00000448841ENST00000369899WBP1Lchr10

104536174

+SUFUchr10

104352338

+
intron-3CDSENST00000448841ENST00000369902WBP1Lchr10

104536174

+SUFUchr10

104352338

+
intron-3CDSENST00000448841ENST00000423559WBP1Lchr10

104536174

+SUFUchr10

104352338

+
intron-3UTRENST00000369889ENST00000471000WBP1Lchr10

104503899

+SUFUchr10

104352338

+
intron-3UTRENST00000369889ENST00000471000WBP1Lchr10

104503900

+SUFUchr10

104352339

+
intron-3UTRENST00000369889ENST00000471000WBP1Lchr10

104503900

+SUFUchr10

104352338

+
intron-3UTRENST00000448841ENST00000471000WBP1Lchr10

104536174

+SUFUchr10

104352338

+
intron-intronENST00000369889ENST00000471000WBP1Lchr10

104503900

+SUFUchr10

104375025

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448841WBP1Lchr10104569811+ENST00000369902SUFUchr10104352339+4820439841439451
ENST00000448841WBP1Lchr10104569811+ENST00000369899SUFUchr10104352339+1678439841286400
ENST00000448841WBP1Lchr10104569811+ENST00000423559SUFUchr10104352339+2512439841430448
ENST00000369889WBP1Lchr10104569811+ENST00000369902SUFUchr10104352339+48154341421434430
ENST00000369889WBP1Lchr10104569811+ENST00000369899SUFUchr10104352339+16734341421281379
ENST00000369889WBP1Lchr10104569811+ENST00000423559SUFUchr10104352339+25074341421425427

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448841ENST00000369902WBP1Lchr10104569811+SUFUchr10104352339+0.0366179050.96338207
ENST00000448841ENST00000369899WBP1Lchr10104569811+SUFUchr10104352339+0.127741020.87225896
ENST00000448841ENST00000423559WBP1Lchr10104569811+SUFUchr10104352339+0.106434910.8935651
ENST00000369889ENST00000369902WBP1Lchr10104569811+SUFUchr10104352339+0.0295800380.97041994
ENST00000369889ENST00000369899WBP1Lchr10104569811+SUFUchr10104352339+0.170339260.8296608
ENST00000369889ENST00000423559WBP1Lchr10104569811+SUFUchr10104352339+0.091051180.90894884

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Fusion Genomic Features for WBP1L-SUFU


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WBP1Lchr10104536174+SUFUchr10104352338+1.36E-050.9999864
WBP1Lchr10104569811+SUFUchr10104352338+3.88E-060.99999607
WBP1Lchr10104503900+SUFUchr10104375024+4.23E-070.9999995
WBP1Lchr10104503900+SUFUchr10104352338+3.10E-081
WBP1Lchr10104503900+SUFUchr10104352338+3.10E-081
WBP1Lchr10104536174+SUFUchr10104352338+1.36E-050.9999864
WBP1Lchr10104569811+SUFUchr10104352338+3.88E-060.99999607
WBP1Lchr10104503900+SUFUchr10104375024+4.23E-070.9999995
WBP1Lchr10104503900+SUFUchr10104352338+3.10E-081
WBP1Lchr10104503900+SUFUchr10104352338+3.10E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for WBP1L-SUFU


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:104536174/chr10:104352338)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WBP1L

Q9NX94

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWBP1Lchr10:104569811chr10:104352339ENST00000369889+3442_6297343.0TransmembraneHelical
HgeneWBP1Lchr10:104569811chr10:104352339ENST00000448841+3442_62118364.0TransmembraneHelical
TgeneSUFUchr10:104569811chr10:104352339ENST00000369899211279_360151434.0RegionIntrinsically disordered
TgeneSUFUchr10:104569811chr10:104352339ENST00000369902212279_360151485.0RegionIntrinsically disordered
TgeneSUFUchr10:104569811chr10:104352339ENST00000423559210279_360151482.0RegionIntrinsically disordered

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWBP1Lchr10:104569811chr10:104352339ENST00000369889+34101_18397343.0Compositional biasNote=Pro-rich
HgeneWBP1Lchr10:104569811chr10:104352339ENST00000369889+34335_34297343.0Compositional biasNote=Poly-Ser
HgeneWBP1Lchr10:104569811chr10:104352339ENST00000448841+34101_183118364.0Compositional biasNote=Pro-rich
HgeneWBP1Lchr10:104569811chr10:104352339ENST00000448841+34335_342118364.0Compositional biasNote=Poly-Ser


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Fusion Gene Sequence for WBP1L-SUFU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98793_98793_1_WBP1L-SUFU_WBP1L_chr10_104569811_ENST00000369889_SUFU_chr10_104352339_ENST00000369899_length(transcript)=1673nt_BP=434nt
TTTACTTTGTCTGCTTTGCTAAAGAAGGCCGGTGAACCAGGACCACCGCACACACAGGCCCACCAGGGGCAATGCTCATTCCAAGACCTT
AACTTTTAAGAGCCCTTTGTTCCAACGTTAGTGTGGACGATGCTCTTGCAGGATGCCTTTCCTTTTGGGTCTTAGACAGGATAAGGAAGC
CTGTGTGGGTACCAACAATCAAAGCTACATCTGTGACACAGGACACTGCTGTGGACAGTCTCAGTGCTGCAACTACTACTATGAACTCTG
GTGGTTCTGGCTGGTGTGGACCATCATCATCATCCTGAGCTGCTGCTGTGTTTGCCACCACCGCCGAGCCAAGCACCGCCTTCAGGCCCA
GCAGCGGCAACATGAAATCAACCTGATCGCTTACCGAGAAGCCCACAATTACTCAGCGCTGCCATTTTATTTCAAGAACACCTTCTGCAG
TGGGGACCATGTGTCCTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACAGAGGACCCACAGATGCAGCC
CGTGCAGACACCCTTTGGGGTAGTTACCTTCCTCCAGATCGTTGGTGTCTGCACTGAAGAGCTACACTCAGCCCAGCAGTGGAACGGGCA
GGGCATCCTGGAGCTGCTGCGGACAGTGCCTATTGCTGGCGGCCCCTGGCTGATAACTGACATGCGGAGGGGAGAGACCATATTTGAGAT
CGATCCACACCTGCAAGAGAGAGTTGACAAAGGCATCGAGACAGATGGCTCCAACCTGAGTGGTGTCAGTGCCAAGTGTGCCTGGGATGA
CCTGAGCCGGCCCCCCGAGGATGACGAGGACAGCCGGAGCATCTGCATCGGCACACAGCCCCGGCGACTCTCTGGCAAAGACACAGAGCA
GATCCGGGAGACCCTGAGGAGAGGACTCGAGATCAACAGCAAACCTGTCCTTCCACCAATCAACCCTCAGCGGCAGAATGGCCTCGCCCA
CGACCGGGCCCCGAGCCGCAAAGACAGCCTGGAAAGTGACAGCTCCACGGCCATCATTCCCCATGAGCTGATTCGCACGCGGCAGCTTGA
GAGCGTACATCTGAAATTCAACCAGGAGTCCGGAGCCCTCATTCCTCTCTGCCTAAGGGGCAGGCTCCTGCATGGACGGCACTTTACATA
TAAAAGTATCACAGGTGACATGGCCATCACGTTTGTCTCCACGGGAGTGGAAGGCGCCTTTGCCACTGAGGAGCATCCTTACGCGGCTCA
TGGACCCTGGTTACAACTCTGAACCTATCCTCGGAGCTCTGCCCTCCCGTCCTGGAACGTCTTTCTGCCCTGAGGAGAGGGTAGTCAGCA
TCTCCAATTTTCAGCAGCTCAAGAACCTTGGCCCCCACAGGACTTCGCAGATGTCACATTGCCCCTCAGTCCCCTGAATGCCCTTCGGAC
CCAACCCCAATTCCCCAAGCCCCTGACCCCCTAGCTGCCGGGGTTCCCACTCCCAGTGCCACAACCCCCTCACCTCCCTGGCAGCCCCTC
AGCGAGCCTGAGGCCCAGCACCCGCTGGCTCCCCAGCACATGGTCCCCTCCCATGGGCTGTTGCCCAGGGAACCGGGGCGCGGTGGGAAC

>98793_98793_1_WBP1L-SUFU_WBP1L_chr10_104569811_ENST00000369889_SUFU_chr10_104352339_ENST00000369899_length(amino acids)=379AA_BP=98
MPFLLGLRQDKEACVGTNNQSYICDTGHCCGQSQCCNYYYELWWFWLVWTIIIILSCCCVCHHRRAKHRLQAQQRQHEINLIAYREAHNY
SALPFYFKNTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWL
ITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVL
PPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVE

--------------------------------------------------------------
>98793_98793_2_WBP1L-SUFU_WBP1L_chr10_104569811_ENST00000369889_SUFU_chr10_104352339_ENST00000369902_length(transcript)=4815nt_BP=434nt
TTTACTTTGTCTGCTTTGCTAAAGAAGGCCGGTGAACCAGGACCACCGCACACACAGGCCCACCAGGGGCAATGCTCATTCCAAGACCTT
AACTTTTAAGAGCCCTTTGTTCCAACGTTAGTGTGGACGATGCTCTTGCAGGATGCCTTTCCTTTTGGGTCTTAGACAGGATAAGGAAGC
CTGTGTGGGTACCAACAATCAAAGCTACATCTGTGACACAGGACACTGCTGTGGACAGTCTCAGTGCTGCAACTACTACTATGAACTCTG
GTGGTTCTGGCTGGTGTGGACCATCATCATCATCCTGAGCTGCTGCTGTGTTTGCCACCACCGCCGAGCCAAGCACCGCCTTCAGGCCCA
GCAGCGGCAACATGAAATCAACCTGATCGCTTACCGAGAAGCCCACAATTACTCAGCGCTGCCATTTTATTTCAAGAACACCTTCTGCAG
TGGGGACCATGTGTCCTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACAGAGGACCCACAGATGCAGCC
CGTGCAGACACCCTTTGGGGTAGTTACCTTCCTCCAGATCGTTGGTGTCTGCACTGAAGAGCTACACTCAGCCCAGCAGTGGAACGGGCA
GGGCATCCTGGAGCTGCTGCGGACAGTGCCTATTGCTGGCGGCCCCTGGCTGATAACTGACATGCGGAGGGGAGAGACCATATTTGAGAT
CGATCCACACCTGCAAGAGAGAGTTGACAAAGGCATCGAGACAGATGGCTCCAACCTGAGTGGTGTCAGTGCCAAGTGTGCCTGGGATGA
CCTGAGCCGGCCCCCCGAGGATGACGAGGACAGCCGGAGCATCTGCATCGGCACACAGCCCCGGCGACTCTCTGGCAAAGACACAGAGCA
GATCCGGGAGACCCTGAGGAGAGGACTCGAGATCAACAGCAAACCTGTCCTTCCACCAATCAACCCTCAGCGGCAGAATGGCCTCGCCCA
CGACCGGGCCCCGAGCCGCAAAGACAGCCTGGAAAGTGACAGCTCCACGGCCATCATTCCCCATGAGCTGATTCGCACGCGGCAGCTTGA
GAGCGTACATCTGAAATTCAACCAGGAGTCCGGAGCCCTCATTCCTCTCTGCCTAAGGGGCAGGCTCCTGCATGGACGGCACTTTACATA
TAAAAGTATCACAGGTGACATGGCCATCACGTTTGTCTCCACGGGAGTGGAAGGCGCCTTTGCCACTGAGGAGCATCCTTACGCGGCTCA
TGGACCCTGGTTACAAATTCTGTTGACCGAAGAGTTTGTAGAGAAAATGTTGGAGGATTTAGAAGATTTGACTTCTCCAGAGGAATTCAA
ACTTCCCAAAGAGTACAGCTGGCCTGAAAAGAAGCTGAAGGTCTCCATCCTGCCTGACGTGGTGTTCGACAGTCCGCTACACTAGCCTGG
GCTGGGCCCTGCAGTGGCCAGCAGGGAGCCCAGCTGCTCCCCAGTGACTTCCAGTGTAACAGTTGTGTCAACGAGATCTCCACAAATAAA
AGGACAAGTGTGAGGAAGACTGCGCAGTGCCACCCCGCAGCCCAGTGGGGTGCCATGCACAGGCCACAGGCCCTCCACCTCACCTCCAGC
TCAGGGGCCGCACCCCGCCGCTGGCTAAGCCTTGTGACCCATCAGGCCAGTGAGTGGGCAAATGCGGACCCTCCCTGCCTGCAGCCTGCA
CAGATTCTGGTTTGAGGTTTGACTCTGGACCCTGGCTGTGCCCCTAGGTGGAGACAGCCCTCTTTCTCACCTACCCCCTGCCGCACAGCC
CAGCAGGAGGGAGGCGGACAGCCAGATGCAGAGCGAGTGGATGCACTTCCCAGCTCATCTCTGGAAGCCTTTGCTACTCAAGCTCCTCTG
GCCGCGGAACAATTCCTCTGATCATGTTTGGTTTTCTTCTTCCTTATTTTATTTTGTAGAAACCGGGTGGTATTTTATTGCTCTGCAAAG
ATGTCCAGAAGCCATGTATATAATGTTTTTTAAACAGAACTTCATTCCCCGTTGAACTTTCGCATTCTCTGACAGAGGCCTAGGGCTGTA
TCTCTCCCTGGGCTGCCACCAGAGAAGGTGCTTGGTGTTCGCCTGCCAGCCCAGAGCCCTGGAGGAGCCGGCTGCACAGAGAGGCTTTTC
TTCCCAGCTGGGCCTGGTGGAGCCCGGGGCAGGGGGAGAGTAGAGACACTCCCTTGTGCAGCTTTGAGCCTAGTTTAGCTGGGGCCAGGG
AGGGGTGCTACTGTTTTCCAAGTGAATGGGTCTCAAAGACTTGGTGACCCCAGCCTCATCTTCTAGGCCTTTTCCACCCAACCAGGCCTA
CCTGGGAGAGGGTGAGGTTCAGCACATCACACACCATCCCCACTGTCATTCAGGGCCTGGGTCTCCAGCTCTGTAACCAGTCCTGTCCCA
TTTCCTCAGTCCCTGGGCCTCCCAGCCTTCAGGCTGTAGGGCTGCCTTACTAAAATTGAAAAATCCACCTCTTAACATCTCTTTCACTTT
GGTTTTGCTAACACTGCTCTCTGCTGCCCTCCCATCCTCCCTGTATCCATTCATGCCCTATCTTTCATTCTCCACTCCTAATCCCTCTCC
TTTCTGGCATCCTGGCCTCTCGTGGTCCTCAGCCCCTCACCCCCAGTACTGCAGATCTCACAGTTTGCCTTCCAGAAGCCAGCCTATCTC
TAGCCCATGGTTTTGGAGTTCCTCTCGGGTTATCTCCCACGCCTGACCTGGAACCAGCAAGCCCCTTTCCTGCCTTCTTACCCCCAACTC
TAGGGATGGGACTGTTACAATACTTCAAGATCACTCTTTACACCTCTTCAAAGCAAAGTCATGACAATGCAGGGCTCCTCATTGCTCCCA
TCTGCCTCTGCTGCACACACAGGCACCAGCAGGGATGCCACAGGAGTGCCCACAGGGTGCAGGACTCCACTGATGAGAGATCCAGCCAAA
GAGCTGCCCCCAGGGGTATGAGGGCACCAGCTGGGTTCTCCAGGGAGCAGGAGTTGGACCTCCATGGAGCCACTAGGCCTGGCCTCCTCT
ACACATCCCCAGGGCTATCTGGTTAATTCCATCAAGCTCAGAGTTAAAAGGCATATCAGCCTGGAGTATTTGGGAGAGACTGGCTGCAGA
TCCCCGCCAGCCAAGATGCAAGCCACTCGGGACCTGATGTCGGCAGCTGTGCCTCTACTGCCCTGAGGACTTACCAGAGGGAGCCCTACT
GGCCTTCCCCCACCACAGCAGCCCTGCCTGTGAAGCTCTTGTTTCTGACATTTCACAGGCAGAGAGGTGCCATCAGTTCGCCTCCATTCC
TTGCCACCATGACCAGCCTCTCCCTGAACTCTCTCTTGCTCGGGACCTGCCTGAGGGCTCCCTGCTGCAGTTCGCCGTACTTCCATCTGC
TGGGTGCCTCCATCGTTGGTTGGGTGGGGATGGGGCATTTTCTGAGCTAAGCTTTGTCATTAGTTTGTGAAGCACCTGGTCAGCAACCTG
CCCCAGACCTGGAGGGTCTTTGTGGACTGAAGGTAGACACCAGCCAGCATGGTGGCCCTGTTCTGGGGGAGCAGGGTAAGGCAGGAGGAA
GTGGGTGAGCTCCGAGATGATGAGCACATGAAGCCTGTGGCCCCTTCGTACCTGCAATATGTCAGGAGCCTCACGCTCACCCAAGATCCT
GCAGGGGCCAGGCTCCATCTCACTGGCTCTGAGGGCAGGACAGGGTATCACACATTTCTCACCAGGCCTCCTTTCCTATGGGCATTGGTG
CCTCCCAGAGGTTTCTTGGGCTGCTGGCTGGTGAGAGAGGACCCTTAAAGAAGATCAAGCCAAGCTGACCTTGGACCCTGTCCAGCACAG
CTTCTGGCACAGGATGCTTGGTGAATGTACCCTTTCTTTCCCTCCCTGCAGCTCTGAGGGAGCCCCTGACCTTGTAGTGGGTGGAGGAGG
TAAGGGGCCTCCCTCCCTAAATCTGCCTCTTCTGCAAGCTACTTGGAGACTTGCCTAGTTGTACCCACCCCTCCAGGTCCCTGGTGCTAG
AGCTTCTGAGAAGGGCCTTTCCCTTTCCTCTTTGCCTGCTATATAAGGCAGGCTCCTGTGGCTCTGCTGGCTCAGTGTGGGCTGCAGGAG
GACTGCAGACTCAGCTGCAATTCTGAGGGGGGTTTGGGAGGCTTGTGCGAGGTCTCAGGCCTGTGTGGGGAGCTGGTGCCTCTTCCTGCC
CGTATCTTTCTCTTCCAAGGGCAGTGCTCCAAGGCAGGGACTGGAGAAGCCAAGGGGAGAGTCTAAAAGGGCTAGAGCATTTTTAAAAAT
AGACACAGGGTCTTGGGACTGGGGTTTCGGATTGAGTTGCAAGCAGGGAGAAAACCTGAAGGTCGGTGCCCCTATGGGGCTGACCAGTAG
AGAATTTCCTTTACTGTATTTTTGTGTCTGGTCTTCCCTTTCTGGCTTCTAGGACATCCATGCCAGGTGAGGTGCCTGGGTCCCTGTTAC
AAGTCAGGAGCCCTGTAGGGAGACCCCTCCTTTTGTACAAGTACCTGAATGCTGCGACAAGCAGATTTTTGTAAAATTTTATATTAGTTT
TTAATGTCAGTGGCGACTCGGTTCCTGGGGCTGCAGCCAGCCTGGGACTTTTGTAAGAATTTTTGGGTGACTCACTTAGATGTCGTTTCC
TTCTTGCCCCCTCTTCCTCTCTGTAATCTAAGTGCATTAAACATCTTTGCAGAAGTGCCTGGGTTGTGTGCTCATTTCTGGCTGCCTGAA

>98793_98793_2_WBP1L-SUFU_WBP1L_chr10_104569811_ENST00000369889_SUFU_chr10_104352339_ENST00000369902_length(amino acids)=430AA_BP=98
MPFLLGLRQDKEACVGTNNQSYICDTGHCCGQSQCCNYYYELWWFWLVWTIIIILSCCCVCHHRRAKHRLQAQQRQHEINLIAYREAHNY
SALPFYFKNTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWL
ITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVL
PPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVE

--------------------------------------------------------------
>98793_98793_3_WBP1L-SUFU_WBP1L_chr10_104569811_ENST00000369889_SUFU_chr10_104352339_ENST00000423559_length(transcript)=2507nt_BP=434nt
TTTACTTTGTCTGCTTTGCTAAAGAAGGCCGGTGAACCAGGACCACCGCACACACAGGCCCACCAGGGGCAATGCTCATTCCAAGACCTT
AACTTTTAAGAGCCCTTTGTTCCAACGTTAGTGTGGACGATGCTCTTGCAGGATGCCTTTCCTTTTGGGTCTTAGACAGGATAAGGAAGC
CTGTGTGGGTACCAACAATCAAAGCTACATCTGTGACACAGGACACTGCTGTGGACAGTCTCAGTGCTGCAACTACTACTATGAACTCTG
GTGGTTCTGGCTGGTGTGGACCATCATCATCATCCTGAGCTGCTGCTGTGTTTGCCACCACCGCCGAGCCAAGCACCGCCTTCAGGCCCA
GCAGCGGCAACATGAAATCAACCTGATCGCTTACCGAGAAGCCCACAATTACTCAGCGCTGCCATTTTATTTCAAGAACACCTTCTGCAG
TGGGGACCATGTGTCCTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACAGAGGACCCACAGATGCAGCC
CGTGCAGACACCCTTTGGGGTAGTTACCTTCCTCCAGATCGTTGGTGTCTGCACTGAAGAGCTACACTCAGCCCAGCAGTGGAACGGGCA
GGGCATCCTGGAGCTGCTGCGGACAGTGCCTATTGCTGGCGGCCCCTGGCTGATAACTGACATGCGGAGGGGAGAGACCATATTTGAGAT
CGATCCACACCTGCAAGAGAGAGTTGACAAAGGCATCGAGACAGATGGCTCCAACCTGAGTGGTGTCAGTGCCAAGTGTGCCTGGGATGA
CCTGAGCCGGCCCCCCGAGGATGACGAGGACAGCCGGAGCATCTGCATCGGCACACAGCCCCGGCGACTCTCTGGCAAAGACACAGAGCA
GATCCGGGAGACCCTGAGGAGAGGACTCGAGATCAACAGCAAACCTGTCCTTCCACCAATCAACCCTCAGCGGCAGAATGGCCTCGCCCA
CGACCGGGCCCCGAGCCGCAAAGACAGCCTGGAAAGTGACAGCTCCACGGCCATCATTCCCCATGAGCTGATTCGCACGCGGCAGCTTGA
GAGCGTACATCTGAAATTCAACCAGGAGTCCGGAGCCCTCATTCCTCTCTGCCTAAGGGGCAGGCTCCTGCATGGACGGCACTTTACATA
TAAAAGTATCACAGGTGACATGGCCATCACGTTTGTCTCCACGGGAGTGGAAGGCGCCTTTGCCACTGAGGAGCATCCTTACGCGGCTCA
TGGACCCTGGTTACAAGTGAGAAGGCCCTTTTTCTTCTCCCTCCTTCCTTTCATAGACTTCCTTGCCCACCCCTCCTCTTCTCCCTTGGC
AGCTCTTGATGGCACCCCTTCCTGGGGGGCTGGTCATGAATGCCTCATGGATTCAGGGCCTGGGGCCTGTGTGTAGGTATGGAGTGTGGA
TGCTGCTACCCACTCCAGCAGCTTAGGAGCACTTCCTGACCTTCTCCCCCTGTCACCTGAGACACAAGTGTTAACTCTCCAGGCCCTGGC
TCTTGGTAATTCTGGTTCCCCGTGGAAATCCAGGTTGGAGGGATATAAGACTTTCTGCACCTTGGGTAAACCAAGGTACAAGAACTCAAG
GATGAAGCAAGATGGGAGGATGTGTGGAGGCCACTCTCCAATGGCTACATGGAAATCCCACCAGAATTCAGACAGTGGCATGTGTGCCTG
GACCAGGGCTGGGCAGGCCTCAGTGGGAAGAGCCTCCCCTTCTTAGCCTACCCCCATCTGACAGCCCTCCCGTTCCTCCTGAGTTTGTGT
GACCAGAGACCTGCTGGCTTATCCGGAGCACTTTGTCCTTCCTTTGCTCTTCTGGCTGGAGCGAGCTTCAGAGCTGTTGCCAAGCAGGGT
ACCAGGGCCTCAGAGCCATAGGCCTCCTTCCAGTCCCCACCCCGTCCCGGGTCTCTAACAGGTGCTCAACCTACTCCACCACACTCCCGA
GTGTCTTGGAGGGACAGCATCCTTTTTTGGCATTTGTTTGTTGCGGGTGGGGAGAGGATTGAACCCTTAACCTCACCTCGCTCGCAAGTA
TCAAGAAAGGGAACCTGACCCTAAACCTAAAGGTGGCCATACCTGGTTTGTGAATGTATTGGAGAGGCATGCAGCATTACAGTAGAGGGG
AAGAGAATGATGCTAGGTTTGTGAGTTTCACCCAGTCTGGGGAGTCTGTGAAGCATATGTAGTCAATACAGACACACTTTTTGTCCCTGC
ATGTCTACAGAATTTCTCCTCCTTCAGGCCAGGCCCCTCTTCTCCCGCCACCACCAAAATACAACCCTTAATTAAAACAAACAGCAAACA
AAGGACACCAACCACACTCCCCAGACTAAGCCGAGATAGAAATGGAAGCTAGTGCTTTAGGGATATTGTGTTCCATAAATTATCTTGCCT

>98793_98793_3_WBP1L-SUFU_WBP1L_chr10_104569811_ENST00000369889_SUFU_chr10_104352339_ENST00000423559_length(amino acids)=427AA_BP=98
MPFLLGLRQDKEACVGTNNQSYICDTGHCCGQSQCCNYYYELWWFWLVWTIIIILSCCCVCHHRRAKHRLQAQQRQHEINLIAYREAHNY
SALPFYFKNTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWL
ITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVL
PPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVE

--------------------------------------------------------------
>98793_98793_4_WBP1L-SUFU_WBP1L_chr10_104569811_ENST00000448841_SUFU_chr10_104352339_ENST00000369899_length(transcript)=1678nt_BP=439nt
GAAGGAAGAAGAGGGTAGAGGAGGAGAGGGAGGAGGAGGAGGGAGGTGGCGGCGCCGTGGCGGAGGAGCAGGAGCAGGAGGGGGATGGAG
AGGAGAAGGCTCCTGGGTGGCATGGCGCTCCTGCTCCTCCAGGCGCTGCCCAGCCCCTTGTCAGCCAGGGCTGAACCCCCGCAGGATAAG
GAAGCCTGTGTGGGTACCAACAATCAAAGCTACATCTGTGACACAGGACACTGCTGTGGACAGTCTCAGTGCTGCAACTACTACTATGAA
CTCTGGTGGTTCTGGCTGGTGTGGACCATCATCATCATCCTGAGCTGCTGCTGTGTTTGCCACCACCGCCGAGCCAAGCACCGCCTTCAG
GCCCAGCAGCGGCAACATGAAATCAACCTGATCGCTTACCGAGAAGCCCACAATTACTCAGCGCTGCCATTTTATTTCAAGAACACCTTC
TGCAGTGGGGACCATGTGTCCTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACAGAGGACCCACAGATG
CAGCCCGTGCAGACACCCTTTGGGGTAGTTACCTTCCTCCAGATCGTTGGTGTCTGCACTGAAGAGCTACACTCAGCCCAGCAGTGGAAC
GGGCAGGGCATCCTGGAGCTGCTGCGGACAGTGCCTATTGCTGGCGGCCCCTGGCTGATAACTGACATGCGGAGGGGAGAGACCATATTT
GAGATCGATCCACACCTGCAAGAGAGAGTTGACAAAGGCATCGAGACAGATGGCTCCAACCTGAGTGGTGTCAGTGCCAAGTGTGCCTGG
GATGACCTGAGCCGGCCCCCCGAGGATGACGAGGACAGCCGGAGCATCTGCATCGGCACACAGCCCCGGCGACTCTCTGGCAAAGACACA
GAGCAGATCCGGGAGACCCTGAGGAGAGGACTCGAGATCAACAGCAAACCTGTCCTTCCACCAATCAACCCTCAGCGGCAGAATGGCCTC
GCCCACGACCGGGCCCCGAGCCGCAAAGACAGCCTGGAAAGTGACAGCTCCACGGCCATCATTCCCCATGAGCTGATTCGCACGCGGCAG
CTTGAGAGCGTACATCTGAAATTCAACCAGGAGTCCGGAGCCCTCATTCCTCTCTGCCTAAGGGGCAGGCTCCTGCATGGACGGCACTTT
ACATATAAAAGTATCACAGGTGACATGGCCATCACGTTTGTCTCCACGGGAGTGGAAGGCGCCTTTGCCACTGAGGAGCATCCTTACGCG
GCTCATGGACCCTGGTTACAACTCTGAACCTATCCTCGGAGCTCTGCCCTCCCGTCCTGGAACGTCTTTCTGCCCTGAGGAGAGGGTAGT
CAGCATCTCCAATTTTCAGCAGCTCAAGAACCTTGGCCCCCACAGGACTTCGCAGATGTCACATTGCCCCTCAGTCCCCTGAATGCCCTT
CGGACCCAACCCCAATTCCCCAAGCCCCTGACCCCCTAGCTGCCGGGGTTCCCACTCCCAGTGCCACAACCCCCTCACCTCCCTGGCAGC
CCCTCAGCGAGCCTGAGGCCCAGCACCCGCTGGCTCCCCAGCACATGGTCCCCTCCCATGGGCTGTTGCCCAGGGAACCGGGGCGCGGTG

>98793_98793_4_WBP1L-SUFU_WBP1L_chr10_104569811_ENST00000448841_SUFU_chr10_104352339_ENST00000369899_length(amino acids)=400AA_BP=119
MERRRLLGGMALLLLQALPSPLSARAEPPQDKEACVGTNNQSYICDTGHCCGQSQCCNYYYELWWFWLVWTIIIILSCCCVCHHRRAKHR
LQAQQRQHEINLIAYREAHNYSALPFYFKNTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQ
WNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGK
DTEQIRETLRRGLEINSKPVLPPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGR

--------------------------------------------------------------
>98793_98793_5_WBP1L-SUFU_WBP1L_chr10_104569811_ENST00000448841_SUFU_chr10_104352339_ENST00000369902_length(transcript)=4820nt_BP=439nt
GAAGGAAGAAGAGGGTAGAGGAGGAGAGGGAGGAGGAGGAGGGAGGTGGCGGCGCCGTGGCGGAGGAGCAGGAGCAGGAGGGGGATGGAG
AGGAGAAGGCTCCTGGGTGGCATGGCGCTCCTGCTCCTCCAGGCGCTGCCCAGCCCCTTGTCAGCCAGGGCTGAACCCCCGCAGGATAAG
GAAGCCTGTGTGGGTACCAACAATCAAAGCTACATCTGTGACACAGGACACTGCTGTGGACAGTCTCAGTGCTGCAACTACTACTATGAA
CTCTGGTGGTTCTGGCTGGTGTGGACCATCATCATCATCCTGAGCTGCTGCTGTGTTTGCCACCACCGCCGAGCCAAGCACCGCCTTCAG
GCCCAGCAGCGGCAACATGAAATCAACCTGATCGCTTACCGAGAAGCCCACAATTACTCAGCGCTGCCATTTTATTTCAAGAACACCTTC
TGCAGTGGGGACCATGTGTCCTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACAGAGGACCCACAGATG
CAGCCCGTGCAGACACCCTTTGGGGTAGTTACCTTCCTCCAGATCGTTGGTGTCTGCACTGAAGAGCTACACTCAGCCCAGCAGTGGAAC
GGGCAGGGCATCCTGGAGCTGCTGCGGACAGTGCCTATTGCTGGCGGCCCCTGGCTGATAACTGACATGCGGAGGGGAGAGACCATATTT
GAGATCGATCCACACCTGCAAGAGAGAGTTGACAAAGGCATCGAGACAGATGGCTCCAACCTGAGTGGTGTCAGTGCCAAGTGTGCCTGG
GATGACCTGAGCCGGCCCCCCGAGGATGACGAGGACAGCCGGAGCATCTGCATCGGCACACAGCCCCGGCGACTCTCTGGCAAAGACACA
GAGCAGATCCGGGAGACCCTGAGGAGAGGACTCGAGATCAACAGCAAACCTGTCCTTCCACCAATCAACCCTCAGCGGCAGAATGGCCTC
GCCCACGACCGGGCCCCGAGCCGCAAAGACAGCCTGGAAAGTGACAGCTCCACGGCCATCATTCCCCATGAGCTGATTCGCACGCGGCAG
CTTGAGAGCGTACATCTGAAATTCAACCAGGAGTCCGGAGCCCTCATTCCTCTCTGCCTAAGGGGCAGGCTCCTGCATGGACGGCACTTT
ACATATAAAAGTATCACAGGTGACATGGCCATCACGTTTGTCTCCACGGGAGTGGAAGGCGCCTTTGCCACTGAGGAGCATCCTTACGCG
GCTCATGGACCCTGGTTACAAATTCTGTTGACCGAAGAGTTTGTAGAGAAAATGTTGGAGGATTTAGAAGATTTGACTTCTCCAGAGGAA
TTCAAACTTCCCAAAGAGTACAGCTGGCCTGAAAAGAAGCTGAAGGTCTCCATCCTGCCTGACGTGGTGTTCGACAGTCCGCTACACTAG
CCTGGGCTGGGCCCTGCAGTGGCCAGCAGGGAGCCCAGCTGCTCCCCAGTGACTTCCAGTGTAACAGTTGTGTCAACGAGATCTCCACAA
ATAAAAGGACAAGTGTGAGGAAGACTGCGCAGTGCCACCCCGCAGCCCAGTGGGGTGCCATGCACAGGCCACAGGCCCTCCACCTCACCT
CCAGCTCAGGGGCCGCACCCCGCCGCTGGCTAAGCCTTGTGACCCATCAGGCCAGTGAGTGGGCAAATGCGGACCCTCCCTGCCTGCAGC
CTGCACAGATTCTGGTTTGAGGTTTGACTCTGGACCCTGGCTGTGCCCCTAGGTGGAGACAGCCCTCTTTCTCACCTACCCCCTGCCGCA
CAGCCCAGCAGGAGGGAGGCGGACAGCCAGATGCAGAGCGAGTGGATGCACTTCCCAGCTCATCTCTGGAAGCCTTTGCTACTCAAGCTC
CTCTGGCCGCGGAACAATTCCTCTGATCATGTTTGGTTTTCTTCTTCCTTATTTTATTTTGTAGAAACCGGGTGGTATTTTATTGCTCTG
CAAAGATGTCCAGAAGCCATGTATATAATGTTTTTTAAACAGAACTTCATTCCCCGTTGAACTTTCGCATTCTCTGACAGAGGCCTAGGG
CTGTATCTCTCCCTGGGCTGCCACCAGAGAAGGTGCTTGGTGTTCGCCTGCCAGCCCAGAGCCCTGGAGGAGCCGGCTGCACAGAGAGGC
TTTTCTTCCCAGCTGGGCCTGGTGGAGCCCGGGGCAGGGGGAGAGTAGAGACACTCCCTTGTGCAGCTTTGAGCCTAGTTTAGCTGGGGC
CAGGGAGGGGTGCTACTGTTTTCCAAGTGAATGGGTCTCAAAGACTTGGTGACCCCAGCCTCATCTTCTAGGCCTTTTCCACCCAACCAG
GCCTACCTGGGAGAGGGTGAGGTTCAGCACATCACACACCATCCCCACTGTCATTCAGGGCCTGGGTCTCCAGCTCTGTAACCAGTCCTG
TCCCATTTCCTCAGTCCCTGGGCCTCCCAGCCTTCAGGCTGTAGGGCTGCCTTACTAAAATTGAAAAATCCACCTCTTAACATCTCTTTC
ACTTTGGTTTTGCTAACACTGCTCTCTGCTGCCCTCCCATCCTCCCTGTATCCATTCATGCCCTATCTTTCATTCTCCACTCCTAATCCC
TCTCCTTTCTGGCATCCTGGCCTCTCGTGGTCCTCAGCCCCTCACCCCCAGTACTGCAGATCTCACAGTTTGCCTTCCAGAAGCCAGCCT
ATCTCTAGCCCATGGTTTTGGAGTTCCTCTCGGGTTATCTCCCACGCCTGACCTGGAACCAGCAAGCCCCTTTCCTGCCTTCTTACCCCC
AACTCTAGGGATGGGACTGTTACAATACTTCAAGATCACTCTTTACACCTCTTCAAAGCAAAGTCATGACAATGCAGGGCTCCTCATTGC
TCCCATCTGCCTCTGCTGCACACACAGGCACCAGCAGGGATGCCACAGGAGTGCCCACAGGGTGCAGGACTCCACTGATGAGAGATCCAG
CCAAAGAGCTGCCCCCAGGGGTATGAGGGCACCAGCTGGGTTCTCCAGGGAGCAGGAGTTGGACCTCCATGGAGCCACTAGGCCTGGCCT
CCTCTACACATCCCCAGGGCTATCTGGTTAATTCCATCAAGCTCAGAGTTAAAAGGCATATCAGCCTGGAGTATTTGGGAGAGACTGGCT
GCAGATCCCCGCCAGCCAAGATGCAAGCCACTCGGGACCTGATGTCGGCAGCTGTGCCTCTACTGCCCTGAGGACTTACCAGAGGGAGCC
CTACTGGCCTTCCCCCACCACAGCAGCCCTGCCTGTGAAGCTCTTGTTTCTGACATTTCACAGGCAGAGAGGTGCCATCAGTTCGCCTCC
ATTCCTTGCCACCATGACCAGCCTCTCCCTGAACTCTCTCTTGCTCGGGACCTGCCTGAGGGCTCCCTGCTGCAGTTCGCCGTACTTCCA
TCTGCTGGGTGCCTCCATCGTTGGTTGGGTGGGGATGGGGCATTTTCTGAGCTAAGCTTTGTCATTAGTTTGTGAAGCACCTGGTCAGCA
ACCTGCCCCAGACCTGGAGGGTCTTTGTGGACTGAAGGTAGACACCAGCCAGCATGGTGGCCCTGTTCTGGGGGAGCAGGGTAAGGCAGG
AGGAAGTGGGTGAGCTCCGAGATGATGAGCACATGAAGCCTGTGGCCCCTTCGTACCTGCAATATGTCAGGAGCCTCACGCTCACCCAAG
ATCCTGCAGGGGCCAGGCTCCATCTCACTGGCTCTGAGGGCAGGACAGGGTATCACACATTTCTCACCAGGCCTCCTTTCCTATGGGCAT
TGGTGCCTCCCAGAGGTTTCTTGGGCTGCTGGCTGGTGAGAGAGGACCCTTAAAGAAGATCAAGCCAAGCTGACCTTGGACCCTGTCCAG
CACAGCTTCTGGCACAGGATGCTTGGTGAATGTACCCTTTCTTTCCCTCCCTGCAGCTCTGAGGGAGCCCCTGACCTTGTAGTGGGTGGA
GGAGGTAAGGGGCCTCCCTCCCTAAATCTGCCTCTTCTGCAAGCTACTTGGAGACTTGCCTAGTTGTACCCACCCCTCCAGGTCCCTGGT
GCTAGAGCTTCTGAGAAGGGCCTTTCCCTTTCCTCTTTGCCTGCTATATAAGGCAGGCTCCTGTGGCTCTGCTGGCTCAGTGTGGGCTGC
AGGAGGACTGCAGACTCAGCTGCAATTCTGAGGGGGGTTTGGGAGGCTTGTGCGAGGTCTCAGGCCTGTGTGGGGAGCTGGTGCCTCTTC
CTGCCCGTATCTTTCTCTTCCAAGGGCAGTGCTCCAAGGCAGGGACTGGAGAAGCCAAGGGGAGAGTCTAAAAGGGCTAGAGCATTTTTA
AAAATAGACACAGGGTCTTGGGACTGGGGTTTCGGATTGAGTTGCAAGCAGGGAGAAAACCTGAAGGTCGGTGCCCCTATGGGGCTGACC
AGTAGAGAATTTCCTTTACTGTATTTTTGTGTCTGGTCTTCCCTTTCTGGCTTCTAGGACATCCATGCCAGGTGAGGTGCCTGGGTCCCT
GTTACAAGTCAGGAGCCCTGTAGGGAGACCCCTCCTTTTGTACAAGTACCTGAATGCTGCGACAAGCAGATTTTTGTAAAATTTTATATT
AGTTTTTAATGTCAGTGGCGACTCGGTTCCTGGGGCTGCAGCCAGCCTGGGACTTTTGTAAGAATTTTTGGGTGACTCACTTAGATGTCG
TTTCCTTCTTGCCCCCTCTTCCTCTCTGTAATCTAAGTGCATTAAACATCTTTGCAGAAGTGCCTGGGTTGTGTGCTCATTTCTGGCTGC

>98793_98793_5_WBP1L-SUFU_WBP1L_chr10_104569811_ENST00000448841_SUFU_chr10_104352339_ENST00000369902_length(amino acids)=451AA_BP=119
MERRRLLGGMALLLLQALPSPLSARAEPPQDKEACVGTNNQSYICDTGHCCGQSQCCNYYYELWWFWLVWTIIIILSCCCVCHHRRAKHR
LQAQQRQHEINLIAYREAHNYSALPFYFKNTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQ
WNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGK
DTEQIRETLRRGLEINSKPVLPPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGR
HFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPL

--------------------------------------------------------------
>98793_98793_6_WBP1L-SUFU_WBP1L_chr10_104569811_ENST00000448841_SUFU_chr10_104352339_ENST00000423559_length(transcript)=2512nt_BP=439nt
GAAGGAAGAAGAGGGTAGAGGAGGAGAGGGAGGAGGAGGAGGGAGGTGGCGGCGCCGTGGCGGAGGAGCAGGAGCAGGAGGGGGATGGAG
AGGAGAAGGCTCCTGGGTGGCATGGCGCTCCTGCTCCTCCAGGCGCTGCCCAGCCCCTTGTCAGCCAGGGCTGAACCCCCGCAGGATAAG
GAAGCCTGTGTGGGTACCAACAATCAAAGCTACATCTGTGACACAGGACACTGCTGTGGACAGTCTCAGTGCTGCAACTACTACTATGAA
CTCTGGTGGTTCTGGCTGGTGTGGACCATCATCATCATCCTGAGCTGCTGCTGTGTTTGCCACCACCGCCGAGCCAAGCACCGCCTTCAG
GCCCAGCAGCGGCAACATGAAATCAACCTGATCGCTTACCGAGAAGCCCACAATTACTCAGCGCTGCCATTTTATTTCAAGAACACCTTC
TGCAGTGGGGACCATGTGTCCTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACAGAGGACCCACAGATG
CAGCCCGTGCAGACACCCTTTGGGGTAGTTACCTTCCTCCAGATCGTTGGTGTCTGCACTGAAGAGCTACACTCAGCCCAGCAGTGGAAC
GGGCAGGGCATCCTGGAGCTGCTGCGGACAGTGCCTATTGCTGGCGGCCCCTGGCTGATAACTGACATGCGGAGGGGAGAGACCATATTT
GAGATCGATCCACACCTGCAAGAGAGAGTTGACAAAGGCATCGAGACAGATGGCTCCAACCTGAGTGGTGTCAGTGCCAAGTGTGCCTGG
GATGACCTGAGCCGGCCCCCCGAGGATGACGAGGACAGCCGGAGCATCTGCATCGGCACACAGCCCCGGCGACTCTCTGGCAAAGACACA
GAGCAGATCCGGGAGACCCTGAGGAGAGGACTCGAGATCAACAGCAAACCTGTCCTTCCACCAATCAACCCTCAGCGGCAGAATGGCCTC
GCCCACGACCGGGCCCCGAGCCGCAAAGACAGCCTGGAAAGTGACAGCTCCACGGCCATCATTCCCCATGAGCTGATTCGCACGCGGCAG
CTTGAGAGCGTACATCTGAAATTCAACCAGGAGTCCGGAGCCCTCATTCCTCTCTGCCTAAGGGGCAGGCTCCTGCATGGACGGCACTTT
ACATATAAAAGTATCACAGGTGACATGGCCATCACGTTTGTCTCCACGGGAGTGGAAGGCGCCTTTGCCACTGAGGAGCATCCTTACGCG
GCTCATGGACCCTGGTTACAAGTGAGAAGGCCCTTTTTCTTCTCCCTCCTTCCTTTCATAGACTTCCTTGCCCACCCCTCCTCTTCTCCC
TTGGCAGCTCTTGATGGCACCCCTTCCTGGGGGGCTGGTCATGAATGCCTCATGGATTCAGGGCCTGGGGCCTGTGTGTAGGTATGGAGT
GTGGATGCTGCTACCCACTCCAGCAGCTTAGGAGCACTTCCTGACCTTCTCCCCCTGTCACCTGAGACACAAGTGTTAACTCTCCAGGCC
CTGGCTCTTGGTAATTCTGGTTCCCCGTGGAAATCCAGGTTGGAGGGATATAAGACTTTCTGCACCTTGGGTAAACCAAGGTACAAGAAC
TCAAGGATGAAGCAAGATGGGAGGATGTGTGGAGGCCACTCTCCAATGGCTACATGGAAATCCCACCAGAATTCAGACAGTGGCATGTGT
GCCTGGACCAGGGCTGGGCAGGCCTCAGTGGGAAGAGCCTCCCCTTCTTAGCCTACCCCCATCTGACAGCCCTCCCGTTCCTCCTGAGTT
TGTGTGACCAGAGACCTGCTGGCTTATCCGGAGCACTTTGTCCTTCCTTTGCTCTTCTGGCTGGAGCGAGCTTCAGAGCTGTTGCCAAGC
AGGGTACCAGGGCCTCAGAGCCATAGGCCTCCTTCCAGTCCCCACCCCGTCCCGGGTCTCTAACAGGTGCTCAACCTACTCCACCACACT
CCCGAGTGTCTTGGAGGGACAGCATCCTTTTTTGGCATTTGTTTGTTGCGGGTGGGGAGAGGATTGAACCCTTAACCTCACCTCGCTCGC
AAGTATCAAGAAAGGGAACCTGACCCTAAACCTAAAGGTGGCCATACCTGGTTTGTGAATGTATTGGAGAGGCATGCAGCATTACAGTAG
AGGGGAAGAGAATGATGCTAGGTTTGTGAGTTTCACCCAGTCTGGGGAGTCTGTGAAGCATATGTAGTCAATACAGACACACTTTTTGTC
CCTGCATGTCTACAGAATTTCTCCTCCTTCAGGCCAGGCCCCTCTTCTCCCGCCACCACCAAAATACAACCCTTAATTAAAACAAACAGC
AAACAAAGGACACCAACCACACTCCCCAGACTAAGCCGAGATAGAAATGGAAGCTAGTGCTTTAGGGATATTGTGTTCCATAAATTATCT

>98793_98793_6_WBP1L-SUFU_WBP1L_chr10_104569811_ENST00000448841_SUFU_chr10_104352339_ENST00000423559_length(amino acids)=448AA_BP=119
MERRRLLGGMALLLLQALPSPLSARAEPPQDKEACVGTNNQSYICDTGHCCGQSQCCNYYYELWWFWLVWTIIIILSCCCVCHHRRAKHR
LQAQQRQHEINLIAYREAHNYSALPFYFKNTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQ
WNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGK
DTEQIRETLRRGLEINSKPVLPPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGR

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Fusion Gene PPI Analysis for WBP1L-SUFU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WBP1L-SUFU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WBP1L-SUFU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource