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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WBP2-NUP85 (FusionGDB2 ID:98804)

Fusion Gene Summary for WBP2-NUP85

check button Fusion gene summary
Fusion gene informationFusion gene name: WBP2-NUP85
Fusion gene ID: 98804
HgeneTgene
Gene symbol

WBP2

NUP85

Gene ID

23558

79902

Gene nameWW domain binding protein 2nucleoporin 85
SynonymsDFNB107|GRAMD6|WBP-2FROUNT|NPHS17|Nup75
Cytomap

17q25.1

17q25.1

Type of geneprotein-codingprotein-coding
DescriptionWW domain-binding protein 2nuclear pore complex protein Nup85nucleoporin 85kDanucleoporin Nup75nucleoporin Nup85
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000254806, ENST00000344296, 
ENST00000433525, ENST00000585462, 
ENST00000590221, ENST00000591399, 
ENST00000590450, 		ENST00000447371, 
ENST00000449421, ENST00000579298, 
ENST00000540768, ENST00000245544, 
ENST00000541827, ENST00000579324, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 9 X 6=486
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/486*10)=-2.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WBP2 [Title/Abstract] AND NUP85 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWBP2(73847647)-NUP85(73211843), # samples:1
Anticipated loss of major functional domain due to fusion event.WBP2-NUP85 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
WBP2-NUP85 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWBP2

GO:0032570

response to progesterone

16772533

HgeneWBP2

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

16772533

HgeneWBP2

GO:0043627

response to estrogen

16772533

HgeneWBP2

GO:0050847

progesterone receptor signaling pathway

16772533


check buttonFusion gene breakpoints across WBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUP85 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADB001249WBP2chr17

73847647

-NUP85chr17

73211843

+


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Fusion Gene ORF analysis for WBP2-NUP85

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000254806ENST00000447371WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000254806ENST00000449421WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000254806ENST00000579298WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000344296ENST00000447371WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000344296ENST00000449421WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000344296ENST00000579298WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000433525ENST00000447371WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000433525ENST00000449421WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000433525ENST00000579298WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000585462ENST00000447371WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000585462ENST00000449421WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000585462ENST00000579298WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000590221ENST00000447371WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000590221ENST00000449421WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000590221ENST00000579298WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000591399ENST00000447371WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000591399ENST00000449421WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-3UTRENST00000591399ENST00000579298WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-intronENST00000254806ENST00000540768WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-intronENST00000344296ENST00000540768WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-intronENST00000433525ENST00000540768WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-intronENST00000585462ENST00000540768WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-intronENST00000590221ENST00000540768WBP2chr17

73847647

-NUP85chr17

73211843

+
5CDS-intronENST00000591399ENST00000540768WBP2chr17

73847647

-NUP85chr17

73211843

+
5UTR-3CDSENST00000590450ENST00000245544WBP2chr17

73847647

-NUP85chr17

73211843

+
5UTR-3CDSENST00000590450ENST00000541827WBP2chr17

73847647

-NUP85chr17

73211843

+
5UTR-3CDSENST00000590450ENST00000579324WBP2chr17

73847647

-NUP85chr17

73211843

+
5UTR-3UTRENST00000590450ENST00000447371WBP2chr17

73847647

-NUP85chr17

73211843

+
5UTR-3UTRENST00000590450ENST00000449421WBP2chr17

73847647

-NUP85chr17

73211843

+
5UTR-3UTRENST00000590450ENST00000579298WBP2chr17

73847647

-NUP85chr17

73211843

+
5UTR-intronENST00000590450ENST00000540768WBP2chr17

73847647

-NUP85chr17

73211843

+
Frame-shiftENST00000344296ENST00000245544WBP2chr17

73847647

-NUP85chr17

73211843

+
Frame-shiftENST00000344296ENST00000541827WBP2chr17

73847647

-NUP85chr17

73211843

+
Frame-shiftENST00000344296ENST00000579324WBP2chr17

73847647

-NUP85chr17

73211843

+
Frame-shiftENST00000585462ENST00000245544WBP2chr17

73847647

-NUP85chr17

73211843

+
Frame-shiftENST00000585462ENST00000541827WBP2chr17

73847647

-NUP85chr17

73211843

+
Frame-shiftENST00000585462ENST00000579324WBP2chr17

73847647

-NUP85chr17

73211843

+
Frame-shiftENST00000591399ENST00000245544WBP2chr17

73847647

-NUP85chr17

73211843

+
Frame-shiftENST00000591399ENST00000541827WBP2chr17

73847647

-NUP85chr17

73211843

+
Frame-shiftENST00000591399ENST00000579324WBP2chr17

73847647

-NUP85chr17

73211843

+
In-frameENST00000254806ENST00000245544WBP2chr17

73847647

-NUP85chr17

73211843

+
In-frameENST00000254806ENST00000541827WBP2chr17

73847647

-NUP85chr17

73211843

+
In-frameENST00000254806ENST00000579324WBP2chr17

73847647

-NUP85chr17

73211843

+
In-frameENST00000433525ENST00000245544WBP2chr17

73847647

-NUP85chr17

73211843

+
In-frameENST00000433525ENST00000541827WBP2chr17

73847647

-NUP85chr17

73211843

+
In-frameENST00000433525ENST00000579324WBP2chr17

73847647

-NUP85chr17

73211843

+
In-frameENST00000590221ENST00000245544WBP2chr17

73847647

-NUP85chr17

73211843

+
In-frameENST00000590221ENST00000541827WBP2chr17

73847647

-NUP85chr17

73211843

+
In-frameENST00000590221ENST00000579324WBP2chr17

73847647

-NUP85chr17

73211843

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254806WBP2chr1773847647-ENST00000245544NUP85chr1773211843+1936291271856609
ENST00000254806WBP2chr1773847647-ENST00000541827NUP85chr1773211843+1935291271856609
ENST00000254806WBP2chr1773847647-ENST00000579324NUP85chr1773211843+1935291271856609
ENST00000590221WBP2chr1773847647-ENST00000245544NUP85chr1773211843+182217791742577
ENST00000590221WBP2chr1773847647-ENST00000541827NUP85chr1773211843+182117791742577
ENST00000590221WBP2chr1773847647-ENST00000579324NUP85chr1773211843+182117791742577
ENST00000433525WBP2chr1773847647-ENST00000245544NUP85chr1773211843+185120681771587
ENST00000433525WBP2chr1773847647-ENST00000541827NUP85chr1773211843+185020681771587
ENST00000433525WBP2chr1773847647-ENST00000579324NUP85chr1773211843+185020681771587

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000254806ENST00000245544WBP2chr1773847647-NUP85chr1773211843+0.0100146430.98998535
ENST00000254806ENST00000541827WBP2chr1773847647-NUP85chr1773211843+0.0101490240.989851
ENST00000254806ENST00000579324WBP2chr1773847647-NUP85chr1773211843+0.0101490240.989851
ENST00000590221ENST00000245544WBP2chr1773847647-NUP85chr1773211843+0.0082781920.9917218
ENST00000590221ENST00000541827WBP2chr1773847647-NUP85chr1773211843+0.0083844960.9916155
ENST00000590221ENST00000579324WBP2chr1773847647-NUP85chr1773211843+0.0083844960.9916155
ENST00000433525ENST00000245544WBP2chr1773847647-NUP85chr1773211843+0.0086976170.9913024
ENST00000433525ENST00000541827WBP2chr1773847647-NUP85chr1773211843+0.0088050890.99119484
ENST00000433525ENST00000579324WBP2chr1773847647-NUP85chr1773211843+0.0088050890.99119484

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Fusion Genomic Features for WBP2-NUP85


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WBP2chr1773847648-NUP85chr1773211848+1.64E-060.99999833
WBP2chr1773847648-NUP85chr1773211848+1.64E-060.99999833

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for WBP2-NUP85


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:73847647/chr17:73211843)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWBP2chr17:73847647chr17:73211843ENST00000254806-28146_25556262.0Compositional biasNote=Pro-rich
HgeneWBP2chr17:73847647chr17:73211843ENST00000591399-39146_25556262.0Compositional biasNote=Pro-rich
HgeneWBP2chr17:73847647chr17:73211843ENST00000254806-281_8456262.0DomainNote=GRAM
HgeneWBP2chr17:73847647chr17:73211843ENST00000591399-391_8456262.0DomainNote=GRAM
HgeneWBP2chr17:73847647chr17:73211843ENST00000254806-28196_20056262.0MotifNote=PPxY motif 1
HgeneWBP2chr17:73847647chr17:73211843ENST00000591399-39196_20056262.0MotifNote=PPxY motif 1


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Fusion Gene Sequence for WBP2-NUP85


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98804_98804_1_WBP2-NUP85_WBP2_chr17_73847647_ENST00000254806_NUP85_chr17_73211843_ENST00000245544_length(transcript)=1936nt_BP=291nt
GGGCCAGCCTCCGCACTCGAGCTTTGATTGGCTGACTCTAATAAGAAGACGCCACTAGGGGCGGGGCGAAGAGGGGCGCAAGCTCATTGC
GTTTTGAGTCTCGGGACCCCTGTTGGAGAGACTATGGCGCTCAACAAGAATCACTCGGAGGGCGGCGGAGTGATCGTCAATAACACCGAG
AGCATCCTAATGTCCTATGATCACGTGGAACTCACATTCAATGACATGAAGAACGTGCCAGAAGCCTTCAAAGGGACCAAGAAAGGCACT
GTCTACCTTACCCCTTACCGGGTCTCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCA
GCTGGCCCTCTCCTCCTCCATCTCCTTGACTGGGTCCGGCTCCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCAGTGAG
AATCCAAGCAAACATGACAGCTTCTGGAACTTGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAG
GAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACC
CAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCT
CACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTA
GTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGT
GAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTG
AGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATG
AGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCC
GAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAG
CAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCT
TGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGAT
TTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTAC
GGGGAGAAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCCTTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTG
ACAGACGCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTCTCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACG
TCAAGAAGACCTGTGCATGGAGAATCTGATACCGAGCAGCTCCAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCT
CTGGCACGAAATCTTGCTCGGGCAATTATAAGAGAAGGCTCACTGGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTATGGCAA

>98804_98804_1_WBP2-NUP85_WBP2_chr17_73847647_ENST00000254806_NUP85_chr17_73211843_ENST00000245544_length(amino acids)=609AA_BP=88
MADSNKKTPLGAGRRGAQAHCVLSLGTPVGETMALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVS
ILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEVDSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASA
GICRIMGDLMRTMPILSPGNTQTLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNP
TVKPIDLHYYAQSSLDLFLGGESSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYA
SGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAA
FATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKYREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQ

--------------------------------------------------------------
>98804_98804_2_WBP2-NUP85_WBP2_chr17_73847647_ENST00000254806_NUP85_chr17_73211843_ENST00000541827_length(transcript)=1935nt_BP=291nt
GGGCCAGCCTCCGCACTCGAGCTTTGATTGGCTGACTCTAATAAGAAGACGCCACTAGGGGCGGGGCGAAGAGGGGCGCAAGCTCATTGC
GTTTTGAGTCTCGGGACCCCTGTTGGAGAGACTATGGCGCTCAACAAGAATCACTCGGAGGGCGGCGGAGTGATCGTCAATAACACCGAG
AGCATCCTAATGTCCTATGATCACGTGGAACTCACATTCAATGACATGAAGAACGTGCCAGAAGCCTTCAAAGGGACCAAGAAAGGCACT
GTCTACCTTACCCCTTACCGGGTCTCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCA
GCTGGCCCTCTCCTCCTCCATCTCCTTGACTGGGTCCGGCTCCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCAGTGAG
AATCCAAGCAAACATGACAGCTTCTGGAACTTGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAG
GAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACC
CAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCT
CACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTA
GTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGT
GAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTG
AGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATG
AGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCC
GAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAG
CAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCT
TGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGAT
TTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTAC
GGGGAGAAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCCTTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTG
ACAGACGCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTCTCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACG
TCAAGAAGACCTGTGCATGGAGAATCTGATACCGAGCAGCTCCAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCT
CTGGCACGAAATCTTGCTCGGGCAATTATAAGAGAAGGCTCACTGGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTATGGCAA

>98804_98804_2_WBP2-NUP85_WBP2_chr17_73847647_ENST00000254806_NUP85_chr17_73211843_ENST00000541827_length(amino acids)=609AA_BP=88
MADSNKKTPLGAGRRGAQAHCVLSLGTPVGETMALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVS
ILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEVDSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASA
GICRIMGDLMRTMPILSPGNTQTLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNP
TVKPIDLHYYAQSSLDLFLGGESSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYA
SGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAA
FATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKYREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQ

--------------------------------------------------------------
>98804_98804_3_WBP2-NUP85_WBP2_chr17_73847647_ENST00000254806_NUP85_chr17_73211843_ENST00000579324_length(transcript)=1935nt_BP=291nt
GGGCCAGCCTCCGCACTCGAGCTTTGATTGGCTGACTCTAATAAGAAGACGCCACTAGGGGCGGGGCGAAGAGGGGCGCAAGCTCATTGC
GTTTTGAGTCTCGGGACCCCTGTTGGAGAGACTATGGCGCTCAACAAGAATCACTCGGAGGGCGGCGGAGTGATCGTCAATAACACCGAG
AGCATCCTAATGTCCTATGATCACGTGGAACTCACATTCAATGACATGAAGAACGTGCCAGAAGCCTTCAAAGGGACCAAGAAAGGCACT
GTCTACCTTACCCCTTACCGGGTCTCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCA
GCTGGCCCTCTCCTCCTCCATCTCCTTGACTGGGTCCGGCTCCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCAGTGAG
AATCCAAGCAAACATGACAGCTTCTGGAACTTGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAG
GAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACC
CAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCT
CACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTA
GTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGT
GAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTG
AGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATG
AGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCC
GAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAG
CAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCT
TGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGAT
TTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTAC
GGGGAGAAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCCTTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTG
ACAGACGCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTCTCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACG
TCAAGAAGACCTGTGCATGGAGAATCTGATACCGAGCAGCTCCAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCT
CTGGCACGAAATCTTGCTCGGGCAATTATAAGAGAAGGCTCACTGGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTATGGCAA

>98804_98804_3_WBP2-NUP85_WBP2_chr17_73847647_ENST00000254806_NUP85_chr17_73211843_ENST00000579324_length(amino acids)=609AA_BP=88
MADSNKKTPLGAGRRGAQAHCVLSLGTPVGETMALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVS
ILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEVDSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASA
GICRIMGDLMRTMPILSPGNTQTLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNP
TVKPIDLHYYAQSSLDLFLGGESSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYA
SGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAA
FATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKYREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQ

--------------------------------------------------------------
>98804_98804_4_WBP2-NUP85_WBP2_chr17_73847647_ENST00000433525_NUP85_chr17_73211843_ENST00000245544_length(transcript)=1851nt_BP=206nt
ATTGCGTTTTGAGTCTCGGGACCCCTGTTGGAGAGACTATGGCGCTCAACAAGAATCACTCGGAGGGCGGCGGAGTGATCGTCAATAACA
CCGAGAGCATCCTAATGTCCTATGATCACGTGGAACTCACATTCAATGACATGAAGAACGTGCCAGAAGCCTTCAAAGGGACCAAGAAAG
GCACTGTCTACCTTACCCCTTACCGGGTCTCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGG
CCCCAGCTGGCCCTCTCCTCCTCCATCTCCTTGACTGGGTCCGGCTCCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCA
GTGAGAATCCAAGCAAACATGACAGCTTCTGGAACTTGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCT
CCAAGGAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGA
ACACCCAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCA
GCCCTCACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATT
TCCTAGTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGG
GAGGTGAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCG
CCCTGAGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCA
ACATGAGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACT
GCCCCGAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCT
GTGAGCAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCC
TCTCTTGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTT
CTGATTTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTA
TGTACGGGGAGAAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCCTTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTC
TGCTGACAGACGCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTCTCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACT
TGACGTCAAGAAGACCTGTGCATGGAGAATCTGATACCGAGCAGCTCCAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGAC
TTTCTCTGGCACGAAATCTTGCTCGGGCAATTATAAGAGAAGGCTCACTGGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTAT

>98804_98804_4_WBP2-NUP85_WBP2_chr17_73847647_ENST00000433525_NUP85_chr17_73211843_ENST00000245544_length(amino acids)=587AA_BP=66
MSLGTPVGETMALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVSILSAMELIWNLCEILFIEVAPA
GPLLLHLLDWVRLHVCEVDSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASAGICRIMGDLMRTMPILSPGNTQ
TLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSLDLFLGGE
SSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHPSLWQLGVDYFDYCPE
LGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDL
DLIDNLGPAMMLSDRLTFLGKYREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELMRCLEDLTS

--------------------------------------------------------------
>98804_98804_5_WBP2-NUP85_WBP2_chr17_73847647_ENST00000433525_NUP85_chr17_73211843_ENST00000541827_length(transcript)=1850nt_BP=206nt
ATTGCGTTTTGAGTCTCGGGACCCCTGTTGGAGAGACTATGGCGCTCAACAAGAATCACTCGGAGGGCGGCGGAGTGATCGTCAATAACA
CCGAGAGCATCCTAATGTCCTATGATCACGTGGAACTCACATTCAATGACATGAAGAACGTGCCAGAAGCCTTCAAAGGGACCAAGAAAG
GCACTGTCTACCTTACCCCTTACCGGGTCTCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGG
CCCCAGCTGGCCCTCTCCTCCTCCATCTCCTTGACTGGGTCCGGCTCCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCA
GTGAGAATCCAAGCAAACATGACAGCTTCTGGAACTTGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCT
CCAAGGAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGA
ACACCCAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCA
GCCCTCACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATT
TCCTAGTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGG
GAGGTGAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCG
CCCTGAGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCA
ACATGAGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACT
GCCCCGAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCT
GTGAGCAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCC
TCTCTTGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTT
CTGATTTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTA
TGTACGGGGAGAAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCCTTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTC
TGCTGACAGACGCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTCTCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACT
TGACGTCAAGAAGACCTGTGCATGGAGAATCTGATACCGAGCAGCTCCAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGAC
TTTCTCTGGCACGAAATCTTGCTCGGGCAATTATAAGAGAAGGCTCACTGGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTAT

>98804_98804_5_WBP2-NUP85_WBP2_chr17_73847647_ENST00000433525_NUP85_chr17_73211843_ENST00000541827_length(amino acids)=587AA_BP=66
MSLGTPVGETMALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVSILSAMELIWNLCEILFIEVAPA
GPLLLHLLDWVRLHVCEVDSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASAGICRIMGDLMRTMPILSPGNTQ
TLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSLDLFLGGE
SSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHPSLWQLGVDYFDYCPE
LGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDL
DLIDNLGPAMMLSDRLTFLGKYREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELMRCLEDLTS

--------------------------------------------------------------
>98804_98804_6_WBP2-NUP85_WBP2_chr17_73847647_ENST00000433525_NUP85_chr17_73211843_ENST00000579324_length(transcript)=1850nt_BP=206nt
ATTGCGTTTTGAGTCTCGGGACCCCTGTTGGAGAGACTATGGCGCTCAACAAGAATCACTCGGAGGGCGGCGGAGTGATCGTCAATAACA
CCGAGAGCATCCTAATGTCCTATGATCACGTGGAACTCACATTCAATGACATGAAGAACGTGCCAGAAGCCTTCAAAGGGACCAAGAAAG
GCACTGTCTACCTTACCCCTTACCGGGTCTCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGG
CCCCAGCTGGCCCTCTCCTCCTCCATCTCCTTGACTGGGTCCGGCTCCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCA
GTGAGAATCCAAGCAAACATGACAGCTTCTGGAACTTGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCT
CCAAGGAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGA
ACACCCAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCA
GCCCTCACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATT
TCCTAGTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGG
GAGGTGAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCG
CCCTGAGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCA
ACATGAGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACT
GCCCCGAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCT
GTGAGCAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCC
TCTCTTGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTT
CTGATTTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTA
TGTACGGGGAGAAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCCTTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTC
TGCTGACAGACGCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTCTCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACT
TGACGTCAAGAAGACCTGTGCATGGAGAATCTGATACCGAGCAGCTCCAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGAC
TTTCTCTGGCACGAAATCTTGCTCGGGCAATTATAAGAGAAGGCTCACTGGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTAT

>98804_98804_6_WBP2-NUP85_WBP2_chr17_73847647_ENST00000433525_NUP85_chr17_73211843_ENST00000579324_length(amino acids)=587AA_BP=66
MSLGTPVGETMALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVSILSAMELIWNLCEILFIEVAPA
GPLLLHLLDWVRLHVCEVDSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASAGICRIMGDLMRTMPILSPGNTQ
TLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSLDLFLGGE
SSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHPSLWQLGVDYFDYCPE
LGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDL
DLIDNLGPAMMLSDRLTFLGKYREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELMRCLEDLTS

--------------------------------------------------------------
>98804_98804_7_WBP2-NUP85_WBP2_chr17_73847647_ENST00000590221_NUP85_chr17_73211843_ENST00000245544_length(transcript)=1822nt_BP=177nt
GGAGAGACTATGGCGCTCAACAAGAATCACTCGGAGGGCGGCGGAGTGATCGTCAATAACACCGAGAGCATCCTAATGTCCTATGATCAC
GTGGAACTCACATTCAATGACATGAAGAACGTGCCAGAAGCCTTCAAAGGGACCAAGAAAGGCACTGTCTACCTTACCCCTTACCGGGTC
TCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCAGCTGGCCCTCTCCTCCTCCATCTC
CTTGACTGGGTCCGGCTCCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCAGTGAGAATCCAAGCAAACATGACAGCTTC
TGGAACTTGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCCGATGCCAGCCCCGCCTCT
GCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACACTGACAGAGCTGGAGCTG
AAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTCTTGAAGATT
ATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTGTACTCCAAT
CCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAACCCCTGGAC
AACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTTGTGGCCCAC
CTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTGCTGGAGTAC
GCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTCTCCCTGGAG
CTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACTGAACAAGTT
CGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCTAAGGATGCC
GCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGACAACCTGGGG
CCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTACGGGGAGAAGCGTTTTGCCGACGCA
GCTTCTCTCCTTCTGTCCTTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTGACAGACGCCTTGCCCCTTTTGGAA
CAGAAACAGGTGATTTTCTCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACGTCAAGAAGACCTGTGCATGGAGAA
TCTGATACCGAGCAGCTCCAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCTCTGGCACGAAATCTTGCTCGGGCA
ATTATAAGAGAAGGCTCACTGGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTATGGCAATGTATATAGATTTTTTTAAAAGAA

>98804_98804_7_WBP2-NUP85_WBP2_chr17_73847647_ENST00000590221_NUP85_chr17_73211843_ENST00000245544_length(amino acids)=577AA_BP=56
MALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDW
VRLHVCEVDSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASAGICRIMGDLMRTMPILSPGNTQTLTELELKWQ
HWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSLDLFLGGESSPEPLDNIL
LAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHPSLWQLGVDYFDYCPELGRVSLELHI
ERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAM
MLSDRLTFLGKYREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELMRCLEDLTSRRPVHGESDT

--------------------------------------------------------------
>98804_98804_8_WBP2-NUP85_WBP2_chr17_73847647_ENST00000590221_NUP85_chr17_73211843_ENST00000541827_length(transcript)=1821nt_BP=177nt
GGAGAGACTATGGCGCTCAACAAGAATCACTCGGAGGGCGGCGGAGTGATCGTCAATAACACCGAGAGCATCCTAATGTCCTATGATCAC
GTGGAACTCACATTCAATGACATGAAGAACGTGCCAGAAGCCTTCAAAGGGACCAAGAAAGGCACTGTCTACCTTACCCCTTACCGGGTC
TCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCAGCTGGCCCTCTCCTCCTCCATCTC
CTTGACTGGGTCCGGCTCCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCAGTGAGAATCCAAGCAAACATGACAGCTTC
TGGAACTTGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCCGATGCCAGCCCCGCCTCT
GCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACACTGACAGAGCTGGAGCTG
AAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTCTTGAAGATT
ATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTGTACTCCAAT
CCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAACCCCTGGAC
AACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTTGTGGCCCAC
CTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTGCTGGAGTAC
GCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTCTCCCTGGAG
CTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACTGAACAAGTT
CGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCTAAGGATGCC
GCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGACAACCTGGGG
CCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTACGGGGAGAAGCGTTTTGCCGACGCA
GCTTCTCTCCTTCTGTCCTTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTGACAGACGCCTTGCCCCTTTTGGAA
CAGAAACAGGTGATTTTCTCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACGTCAAGAAGACCTGTGCATGGAGAA
TCTGATACCGAGCAGCTCCAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCTCTGGCACGAAATCTTGCTCGGGCA
ATTATAAGAGAAGGCTCACTGGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTATGGCAATGTATATAGATTTTTTTAAAAGAA

>98804_98804_8_WBP2-NUP85_WBP2_chr17_73847647_ENST00000590221_NUP85_chr17_73211843_ENST00000541827_length(amino acids)=577AA_BP=56
MALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDW
VRLHVCEVDSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASAGICRIMGDLMRTMPILSPGNTQTLTELELKWQ
HWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSLDLFLGGESSPEPLDNIL
LAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHPSLWQLGVDYFDYCPELGRVSLELHI
ERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAM
MLSDRLTFLGKYREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELMRCLEDLTSRRPVHGESDT

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>98804_98804_9_WBP2-NUP85_WBP2_chr17_73847647_ENST00000590221_NUP85_chr17_73211843_ENST00000579324_length(transcript)=1821nt_BP=177nt
GGAGAGACTATGGCGCTCAACAAGAATCACTCGGAGGGCGGCGGAGTGATCGTCAATAACACCGAGAGCATCCTAATGTCCTATGATCAC
GTGGAACTCACATTCAATGACATGAAGAACGTGCCAGAAGCCTTCAAAGGGACCAAGAAAGGCACTGTCTACCTTACCCCTTACCGGGTC
TCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCAGCTGGCCCTCTCCTCCTCCATCTC
CTTGACTGGGTCCGGCTCCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCAGTGAGAATCCAAGCAAACATGACAGCTTC
TGGAACTTGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCCGATGCCAGCCCCGCCTCT
GCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACACTGACAGAGCTGGAGCTG
AAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTCTTGAAGATT
ATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTGTACTCCAAT
CCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAACCCCTGGAC
AACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTTGTGGCCCAC
CTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTGCTGGAGTAC
GCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTCTCCCTGGAG
CTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACTGAACAAGTT
CGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCTAAGGATGCC
GCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGACAACCTGGGG
CCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTACGGGGAGAAGCGTTTTGCCGACGCA
GCTTCTCTCCTTCTGTCCTTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTGACAGACGCCTTGCCCCTTTTGGAA
CAGAAACAGGTGATTTTCTCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACGTCAAGAAGACCTGTGCATGGAGAA
TCTGATACCGAGCAGCTCCAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCTCTGGCACGAAATCTTGCTCGGGCA
ATTATAAGAGAAGGCTCACTGGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTATGGCAATGTATATAGATTTTTTTAAAAGAA

>98804_98804_9_WBP2-NUP85_WBP2_chr17_73847647_ENST00000590221_NUP85_chr17_73211843_ENST00000579324_length(amino acids)=577AA_BP=56
MALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDW
VRLHVCEVDSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASAGICRIMGDLMRTMPILSPGNTQTLTELELKWQ
HWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSLDLFLGGESSPEPLDNIL
LAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHPSLWQLGVDYFDYCPELGRVSLELHI
ERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAM
MLSDRLTFLGKYREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELMRCLEDLTSRRPVHGESDT

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Fusion Gene PPI Analysis for WBP2-NUP85


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WBP2-NUP85


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WBP2-NUP85


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource